MCID: MLG041
MIFTS: 36

Malignant Triton Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Triton Tumor

MalaCards integrated aliases for Malignant Triton Tumor:

Name: Malignant Triton Tumor 12 60 15
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcomatous Differenciation 60
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation 74
Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma 12
Mpnst with Rhabdomyosarcomatous Differentiation 60
Mpnst with Rhabdomyoblastic Differentiation 12
Mpnst with Rhabdomyosarcoma 12
Malignant Triton Tumour 12
Mtt 60

Characteristics:

Orphanet epidemiological data:

60
malignant triton tumor
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6707
NCIt 51 C4335
SNOMED-CT 69 354002
UMLS via Orphanet 75 C0334616
Orphanet 60 ORPHA252212
UMLS 74 C0334616

Summaries for Malignant Triton Tumor

MalaCards based summary : Malignant Triton Tumor, also known as malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differenciation, is related to malignant peripheral nerve sheath tumor and hemangiopericytoma, malignant. An important gene associated with Malignant Triton Tumor is MB (Myoglobin). The drugs Ifosfamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include breast, myeloid and lung, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia : 77 Malignant triton tumor (MTT) is a relatively rare, aggressive tumor made up of both malignant schwannoma... more...

Related Diseases for Malignant Triton Tumor

Diseases related to Malignant Triton Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 malignant peripheral nerve sheath tumor 32.4 NF1 S100B
2 hemangiopericytoma, malignant 30.0 DES S100B
3 neurofibroma 29.7 NF1 S100B
4 neurofibrosarcoma 11.7
5 neurofibromatosis, type iv, of riccardi 10.4
6 leukemia 10.4
7 neurofibromatosis, type i 10.4
8 breast rhabdomyosarcoma 10.1 MB MYOD1
9 acute leukemia 10.1
10 adenocarcinoma 10.1
11 childhood leukemia 10.1
12 histiocytoma 10.1 MB MYOD1
13 pleomorphic rhabdomyosarcoma 10.1 MB MYOD1
14 adult fibrosarcoma 10.1 MB MYOD1
15 rhabdoid cancer 10.1 MB MYOD1
16 gas gangrene 10.1 MB MYOD1
17 giant cell myocarditis 10.1 DES MB
18 myofibroma 10.1 DES MB
19 bilateral retinoblastoma 10.1 DES MB
20 acute mountain sickness 10.1 MB S100B
21 liposarcoma 10.0 DES MB
22 gallbladder sarcoma 10.0 DES MYOD1
23 syringocystadenoma papilliferum 10.0 DES S100B
24 gastric cancer 10.0
25 lymphocytic leukemia 10.0
26 carcinosarcoma 10.0
27 ossifying fibromyxoid tumor 10.0 DES S100B
28 myxofibrosarcoma 10.0 DES S100B
29 adenosarcoma 10.0 DES MB
30 malignant fibrous histiocytoma of bone 10.0 DES MYOD1
31 fibrous histiocytoma 10.0 DES S100B
32 horner's syndrome 10.0 DES MYOD1
33 infantile myofibromatosis 10.0 DES MB
34 syringoma 10.0 DES S100B
35 juvenile xanthogranuloma 10.0 DES S100B
36 pleomorphic liposarcoma 10.0 DES S100B
37 skeletal muscle cancer 10.0 MB MYOD1
38 uterine sarcoma 10.0 DES MB
39 extraosseous ewing's sarcoma 10.0 MYOD1 S100B
40 cutaneous fibrous histiocytoma 10.0 DES S100B
41 muscle tissue disease 10.0 MB MYOD1
42 spindle cell sarcoma 10.0 DES S100B
43 granular cell tumor 10.0 DES S100B
44 tarsal tunnel syndrome 10.0
45 pituitary adenoma 10.0
46 adenoma 10.0
47 li-fraumeni syndrome 10.0
48 li-fraumeni syndrome 2 10.0
49 trigeminal nerve neoplasm 10.0
50 trachea carcinoma 10.0

Graphical network of the top 20 diseases related to Malignant Triton Tumor:



Diseases related to Malignant Triton Tumor

Symptoms & Phenotypes for Malignant Triton Tumor

MGI Mouse Phenotypes related to Malignant Triton Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 DES MB MYOD1 NF1 S100B
2 muscle MP:0005369 8.92 DES MB MYOD1 NF1

Drugs & Therapeutics for Malignant Triton Tumor

Drugs for Malignant Triton Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
3
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
6
Doxil Approved June 1999 Phase 2, Phase 3 31703
7
Isophosphamide mustard Phase 2, Phase 3 0
8 Anti-Bacterial Agents Phase 2, Phase 3
9 Antineoplastic Agents, Alkylating Phase 2, Phase 3
10 Topoisomerase Inhibitors Phase 2, Phase 3
11 Alkylating Agents Phase 2, Phase 3
12 Antibiotics, Antitubercular Phase 2, Phase 3
13
Mesna Approved, Investigational Phase 2 3375-50-6 598

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
2 Hypofractionated Radiotherapy With Sequential Chemotherapy in Primary Unresectable or Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall Recruiting NCT03651375 Phase 2 Sequential chemotherapy - 3 courses of AI

Search NIH Clinical Center for Malignant Triton Tumor

Genetic Tests for Malignant Triton Tumor

Anatomical Context for Malignant Triton Tumor

MalaCards organs/tissues related to Malignant Triton Tumor:

42
Breast, Myeloid, Lung, Thyroid, Small Intestine, Kidney, Spinal Cord

Publications for Malignant Triton Tumor

Articles related to Malignant Triton Tumor:

(show top 50) (show all 79)
# Title Authors Year
1
Teaching NeuroImages: Intracranial malignant triton tumor: An uncommon location of a rare tumor. ( 30886081 )
2019
2
Malignant triton tumor of the gluteal region in a patient unaffected by neurofibromatosis: A case report. ( 29110923 )
2018
3
Malignant triton tumor of trigeminal nerve-case report. ( 29279963 )
2018
4
Expert's comment concerning Grand Rounds case entitled "Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor" by S. Ghailane et al. (Eur Spine J; 2017: DOI 10.1007/s00586-017-5277-2). ( 29671111 )
2018
5
A rare case of intracranial malignant triton tumor arising in the middle cranial fossa: a case report and review of the literature. ( 30509044 )
2018
6
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
7
Malignant Triton Tumor (Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation) Occurring in a Vascularized Free Flap Reconstruction Graft. ( 28387148 )
2017
8
Malignant Triton Tumor of the Kidney. New Location Not Previously Reported. ( 26159374 )
2017
9
Malignant triton tumor of the lung, infiltrating the left atrium and left ventricle, with metastasis to the small intestine. ( 28515751 )
2017
10
Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor. ( 28924675 )
2017
11
A Case of Retroperitoneal Malignant Triton Tumor in a Nigerian Boy. ( 29089742 )
2017
12
A rare case of recurrent malignant triton tumor in a male with NF1: Case report and mini-review. ( 26975033 )
2016
13
A case of recurrent malignant triton tumor successfully treated with radiotherapy. ( 27146005 )
2016
14
Insidious malignant triton tumor of the chest wall with late flare-up. ( 28757738 )
2016
15
Malignant triton tumor of the cervical spine: report of one case and review of the literature. ( 23597523 )
2015
16
Primary epididymis malignant triton tumor: case report and review of the literature. ( 26392076 )
2015
17
Analysis of clinical features and prognosis of malignant triton tumor: A report of two cases and literature review. ( 26788168 )
2015
18
Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. ( 23633163 )
2014
19
Malignant triton tumor of the anterior mediastinum: A case report. ( 24527089 )
2014
20
Malignant Triton Tumor of the Sciatic Nerve as a Secondary Malignancy after Extended Field Radiotherapy and Chemotherapy of Hodgkin's Disease. ( 24803902 )
2014
21
Low-grade malignant triton tumor of the neck: a case report and review of the literature. ( 25328740 )
2014
22
A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. ( 24474920 )
2013
23
A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. ( 23607247 )
2013
24
Malignant triton tumor: a rare case. ( 24426617 )
2013
25
Malignant triton tumor of the chest wall invading the lung. A case report and literature review. ( 24470743 )
2013
26
Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. ( 21732991 )
2012
27
A rare case of malignant triton tumor in the cerebellopontine angle. ( 22515616 )
2012
28
Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. ( 22610852 )
2012
29
Treatment of malignant triton tumor in zygomatic region. ( 22627455 )
2012
30
Malignant triton tumor of the retroperitoneum: a case report and review of the literature. ( 22647059 )
2012
31
Malignant triton tumor of cervical spine with hemorrhage. ( 21414786 )
2011
32
Long-term survival of a patient with a neurofibromatosis Type 1 associated retroperitoneal malignant triton tumor after multi-modality treatment. ( 22011741 )
2011
33
Intracardiac malignant Triton tumor: a first presentation. ( 20172170 )
2010
34
A Rare Malignant Triton Tumor. ( 20671860 )
2010
35
Pathology quiz case 1. Diagnosis: Sinonasal malignant Triton tumor (MTT) with intracranial extension. ( 20855691 )
2010
36
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
37
A rare case of malignant triton tumor with pluridirectional differentiation. ( 19279515 )
2009
38
Prognostic factors for the malignant triton tumor of the head and neck. ( 19283843 )
2009
39
Malignant triton tumor of the infratemporal fossa. ( 19625850 )
2009
40
Malignant Triton tumor in the retroperitoneal space associated with neurofibromatosis type 1: a case study. ( 21139906 )
2009
41
Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. ( 18636196 )
2008
42
Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation. ( 16333835 )
2007
43
Chemotherapy in metastatic malignant triton tumor: report on two cases. ( 17786333 )
2007
44
Malignant triton tumor in a patient with neurofibromatosis type 1. ( 27278294 )
2007
45
Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). ( 17149968 )
2006
46
Malignant triton tumor (MTT) of the neck. ( 16185834 )
2006
47
Malignant triton tumor of the pelvis in a 2-year-old boy. ( 16679944 )
2006
48
Malignant triton tumor presenting as a rectal mass in an 11-month-old. ( 15827834 )
2005
49
Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (malignant triton tumor) with balanced t(7;9)(q11.2;p24) and unbalanced translocation der(16)t(1;16)(q23;q13). ( 15104279 )
2004
50
Radiation-induced malignant triton tumor associated with severe spinal cord compression. Case report and review of the literature. ( 15029921 )
2004

Variations for Malignant Triton Tumor

Expression for Malignant Triton Tumor

Search GEO for disease gene expression data for Malignant Triton Tumor.

Pathways for Malignant Triton Tumor

GO Terms for Malignant Triton Tumor

Biological processes related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 8.62 MYOD1 NF1

Sources for Malignant Triton Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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