MTT
MCID: MLG041
MIFTS: 32

Malignant Triton Tumor (MTT)

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Triton Tumor

MalaCards integrated aliases for Malignant Triton Tumor:

Name: Malignant Triton Tumor 12 59 15
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcomatous Differenciation 59
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation 73
Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma 12
Mpnst with Rhabdomyosarcomatous Differentiation 59
Mpnst with Rhabdomyoblastic Differentiation 12
Mpnst with Rhabdomyosarcoma 12
Malignant Triton Tumour 12
Mtt 59

Characteristics:

Orphanet epidemiological data:

59
malignant triton tumor
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6707
NCIt 50 C4335
SNOMED-CT 68 354002
Orphanet 59 ORPHA252212
UMLS via Orphanet 74 C0334616
UMLS 73 C0334616

Summaries for Malignant Triton Tumor

MalaCards based summary : Malignant Triton Tumor, also known as malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differenciation, is related to malignant peripheral nerve sheath tumor and neurofibroma. An important gene associated with Malignant Triton Tumor is MB (Myoglobin). The drugs Mechlorethamine and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include lung, small intestine and spinal cord, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia : 76 Malignant triton tumor (MTT) is a relatively rare, aggressive tumor made up of both malignant schwannoma... more...

Related Diseases for Malignant Triton Tumor

Diseases related to Malignant Triton Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 malignant peripheral nerve sheath tumor 32.4 NF1 S100B
2 neurofibroma 29.8 NF1 S100B
3 neurofibrosarcoma 11.6
4 neurofibromatosis, type i 10.4
5 leukemia 10.3
6 childhood leukemia 10.1
7 breast rhabdomyosarcoma 10.1 MB MYOD1
8 histiocytoma 10.1 MB MYOD1
9 pleomorphic rhabdomyosarcoma 10.1 MB MYOD1
10 adult fibrosarcoma 10.1 MB MYOD1
11 rhabdoid cancer 10.1 MB MYOD1
12 gas gangrene 10.1 MB MYOD1
13 giant cell myocarditis 10.1 DES MB
14 myofibroma 10.0 DES MB
15 bilateral retinoblastoma 10.0 DES MB
16 acute mountain sickness 10.0 MB S100B
17 lymphocytic leukemia 10.0
18 liposarcoma 10.0 DES MB
19 gallbladder sarcoma 10.0 DES MYOD1
20 syringocystadenoma papilliferum 10.0 DES S100B
21 ossifying fibromyxoid tumor 10.0 DES S100B
22 myxofibrosarcoma 10.0 DES S100B
23 adenosarcoma 10.0 DES MB
24 dedifferentiated liposarcoma 10.0 DES MB
25 malignant fibrous histiocytoma of bone 10.0 DES MYOD1
26 fibrous histiocytoma 10.0 DES S100B
27 horner's syndrome 10.0 DES MYOD1
28 syringoma 10.0 DES S100B
29 infantile myofibromatosis 10.0 DES MB
30 juvenile xanthogranuloma 10.0 DES S100B
31 pleomorphic liposarcoma 10.0 DES S100B
32 skeletal muscle cancer 10.0 MB MYOD1
33 cutaneous fibrous histiocytoma 10.0 DES S100B
34 uterine sarcoma 10.0 DES MB
35 extraosseous ewing's sarcoma 10.0 MYOD1 S100B
36 muscle tissue disease 10.0 MB MYOD1
37 spindle cell sarcoma 10.0 DES S100B
38 granular cell tumor 10.0 DES S100B
39 pituitary adenoma 10.0
40 adenoma 10.0
41 hemangiopericytoma, malignant 10.0 DES S100B
42 orbit embryonal rhabdomyosarcoma 10.0 MB NF1
43 orbit rhabdomyosarcoma 10.0 MB NF1
44 li-fraumeni syndrome 10.0
45 neurofibromatosis, type iv, of riccardi 10.0
46 li-fraumeni syndrome 2 10.0
47 trigeminal nerve neoplasm 10.0
48 brachial plexus neoplasm 10.0
49 foot drop 10.0
50 rhabdoid tumor predisposition syndrome 1 10.0 DES MYOD1

Graphical network of the top 20 diseases related to Malignant Triton Tumor:



Diseases related to Malignant Triton Tumor

Symptoms & Phenotypes for Malignant Triton Tumor

MGI Mouse Phenotypes related to Malignant Triton Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 DES MB MYOD1 NF1 S100B
2 muscle MP:0005369 8.92 DES MB MYOD1 NF1

Drugs & Therapeutics for Malignant Triton Tumor

Drugs for Malignant Triton Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Antibiotics, Antitubercular Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Topoisomerase Inhibitors Phase 2, Phase 3
12
Mesna Approved, Investigational Phase 2 3375-50-6 598

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Hypofractionated Radiotherapy With Sequential Chemotherapy in Primary Unresectable or Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall Recruiting NCT03651375 Phase 2 Sequential chemotherapy - 3 courses of AI

Search NIH Clinical Center for Malignant Triton Tumor

Genetic Tests for Malignant Triton Tumor

Anatomical Context for Malignant Triton Tumor

MalaCards organs/tissues related to Malignant Triton Tumor:

41
Lung, Small Intestine, Spinal Cord, Bone, Pituitary, Skeletal Muscle, Myeloid

Publications for Malignant Triton Tumor

Articles related to Malignant Triton Tumor:

(show top 50) (show all 74)
# Title Authors Year
1
Expert's comment concerning Grand Rounds case entitled "Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor" by S. Ghailane et al. (Eur Spine J; 2017: DOI 10.1007/s00586-017-5277-2). ( 29671111 )
2018
2
A rare case of intracranial malignant triton tumor arising in the middle cranial fossa: a case report and review of the literature. ( 30509044 )
2018
3
Malignant triton tumor of the lung, infiltrating the left atrium and left ventricle, with metastasis to the small intestine. ( 28515751 )
2017
4
Malignant triton tumor of the gluteal region in a patient unaffected by neurofibromatosis: A case report. ( 29110923 )
2017
5
Malignant triton tumor of trigeminal nerve-case report. ( 29279963 )
2017
6
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
7
A Case of Retroperitoneal Malignant Triton Tumor in a Nigerian Boy. ( 29089742 )
2017
8
Malignant Triton Tumor (Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation) Occurring in a Vascularized Free Flap Reconstruction Graft. ( 28387148 )
2017
9
Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor. ( 28924675 )
2017
10
A rare case of recurrent malignant triton tumor in a male with NF1: Case report and mini-review. ( 26975033 )
2016
11
A case of recurrent malignant triton tumor successfully treated with radiotherapy. ( 27146005 )
2016
12
Insidious malignant triton tumor of the chest wall with late flare-up. ( 28757738 )
2016
13
Malignant Triton Tumor of the Kidney. New Location Not Previously Reported. ( 26159374 )
2015
14
Analysis of clinical features and prognosis of malignant triton tumor: A report of two cases and literature review. ( 26788168 )
2015
15
Primary epididymis malignant triton tumor: case report and review of the literature. ( 26392076 )
2015
16
Malignant triton tumor of the anterior mediastinum: A case report. ( 24527089 )
2014
17
Malignant Triton Tumor of the Sciatic Nerve as a Secondary Malignancy after Extended Field Radiotherapy and Chemotherapy of Hodgkin's Disease. ( 24803902 )
2014
18
Low-grade malignant triton tumor of the neck: a case report and review of the literature. ( 25328740 )
2014
19
A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. ( 24474920 )
2013
20
A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. ( 23607247 )
2013
21
Malignant triton tumor: a rare case. ( 24426617 )
2013
22
Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. ( 23633163 )
2013
23
Malignant Triton Tumor of Cervical Spine: Report of One Case and Review of the Literature. ( 23597523 )
2013
24
Malignant triton tumor of the chest wall invading the lung. A case report and literature review. ( 24470743 )
2013
25
Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. ( 21732991 )
2012
26
A rare case of malignant triton tumor in the cerebellopontine angle. ( 22515616 )
2012
27
Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. ( 22610852 )
2012
28
Malignant triton tumor of the retroperitoneum: a case report and review of the literature. ( 22647059 )
2012
29
Treatment of malignant triton tumor in zygomatic region. ( 22627455 )
2012
30
Long-term survival of a patient with a neurofibromatosis Type 1 associated retroperitoneal malignant triton tumor after multi-modality treatment. ( 22011741 )
2011
31
Malignant triton tumor of cervical spine with hemorrhage. ( 21414786 )
2011
32
A Rare Malignant Triton Tumor. ( 20671860 )
2010
33
Intracardiac malignant Triton tumor: a first presentation. ( 20172170 )
2010
34
Pathology quiz case 1. Diagnosis: Sinonasal malignant Triton tumor (MTT) with intracranial extension. ( 20855691 )
2010
35
Malignant triton tumor of the infratemporal fossa. ( 19625850 )
2009
36
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
37
Malignant Triton tumor in the retroperitoneal space associated with neurofibromatosis type 1: a case study. ( 21139906 )
2009
38
Prognostic factors for the malignant triton tumor of the head and neck. ( 19283843 )
2009
39
A rare case of malignant triton tumor with pluridirectional differentiation. ( 19279515 )
2009
40
Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. ( 18636196 )
2008
41
Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation. ( 16333835 )
2007
42
Chemotherapy in metastatic malignant triton tumor: report on two cases. ( 17786333 )
2007
43
Malignant triton tumor in a patient with neurofibromatosis type 1. ( 27278294 )
2007
44
Malignant triton tumor of the pelvis in a 2-year-old boy. ( 16679944 )
2006
45
Malignant triton tumor (MTT) of the neck. ( 16185834 )
2006
46
Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). ( 17149968 )
2006
47
Malignant triton tumor presenting as a rectal mass in an 11-month-old. ( 15827834 )
2005
48
Malignant triton tumor of the lumbar spine. ( 15371720 )
2004
49
Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (malignant triton tumor) with balanced t(7;9)(q11.2;p24) and unbalanced translocation der(16)t(1;16)(q23;q13). ( 15104279 )
2004
50
Radiation-induced malignant triton tumor associated with severe spinal cord compression. Case report and review of the literature. ( 15029921 )
2004

Variations for Malignant Triton Tumor

Expression for Malignant Triton Tumor

Search GEO for disease gene expression data for Malignant Triton Tumor.

Pathways for Malignant Triton Tumor

GO Terms for Malignant Triton Tumor

Biological processes related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 8.62 MYOD1 NF1

Sources for Malignant Triton Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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