MTT
MCID: MLG041
MIFTS: 32

Malignant Triton Tumor (MTT)

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Triton Tumor

MalaCards integrated aliases for Malignant Triton Tumor:

Name: Malignant Triton Tumor 12 58 15
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcomatous Differenciation 58
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation 70
Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma 12
Mpnst with Rhabdomyosarcomatous Differentiation 58
Mpnst with Rhabdomyoblastic Differentiation 12
Mpnst with Rhabdomyosarcoma 12
Malignant Triton Tumour 12
Mtt 58

Characteristics:

Orphanet epidemiological data:

58
malignant triton tumor
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6707
NCIt 50 C4335
SNOMED-CT 67 354002
UMLS via Orphanet 71 C0334616
Orphanet 58 ORPHA252212
UMLS 70 C0334616

Summaries for Malignant Triton Tumor

MalaCards based summary : Malignant Triton Tumor, also known as malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differenciation, is related to neurilemmoma and neurofibroma. An important gene associated with Malignant Triton Tumor is MB (Myoglobin), and among its related pathways/superpathways are Myogenesis and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include small intestine and spinal cord, and related phenotype is muscle.

Wikipedia : 73 Malignant triton tumor (MTT) is a relatively rare, aggressive tumor made up of both malignant schwannoma... more...

Related Diseases for Malignant Triton Tumor

Diseases related to Malignant Triton Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 31.1 S100B NF1 DES
2 neurofibroma 30.4 S100B NF1 MLANA
3 adenosarcoma 30.3 MB DES
4 fibrous histiocytoma 30.3 S100B DES
5 spindle cell sarcoma 29.8 TLE1 S100B MYOG DES
6 liposarcoma 29.7 NF1 MYOG MB DES
7 botryoid rhabdomyosarcoma 29.6 MYOG MYOD1 MB DES
8 malignant mesenchymoma 29.6 MYOG MYOD1 MB DES
9 embryonal rhabdomyosarcoma 29.6 MYOG MYOD1 MB DES
10 hemangiopericytoma, malignant 29.6 TLE1 S100B MYOG DES
11 rhabdomyosarcoma 29.6 S100B NF1 MYOG MYOD1 MB DES
12 gas gangrene 29.6 MYOG MYOD1 MB
13 malignant peripheral nerve sheath tumor 29.5 TLE1 S100B NF1 MYOG MLANA B3GAT1
14 sarcoma, synovial 29.3 TLE1 S100B NF1 MYOG DES
15 malignant fibrous histiocytoma 29.2 S100B MYOG MYOD1 MB DES
16 neurofibromatosis 10.8
17 pituitary tumors 10.5
18 rare tumor 10.4
19 neurofibromatosis, type i 10.3
20 giant cell myocarditis 10.3 MB DES
21 malignant giant cell tumor of soft parts 10.2 S100B MB
22 soft tissue sarcoma 10.2
23 cutaneous leiomyosarcoma 10.2 S100B DES
24 fibroma 10.2 NF1 DES
25 acute mountain sickness 10.2 S100B MB
26 syringocystadenoma papilliferum 10.2 S100B DES
27 ossifying fibromyxoid tumor 10.2 S100B DES
28 epithelioid leiomyosarcoma 10.2 MB DES
29 myofibroma 10.2 MB DES
30 ovarian small cell carcinoma 10.2 S100B DES
31 syringoma 10.2 S100B DES
32 optic nerve glioma 10.2 S100B NF1
33 olfactory neuroblastoma 10.2 S100B MB
34 pleomorphic liposarcoma 10.2 S100B DES
35 neuroleptic malignant syndrome 10.2 MB DES
36 cervical polyp 10.2 MYOG DES
37 infantile myofibromatosis 10.2 MB DES
38 ectomesenchymoma 10.2 MYOG DES
39 perineurioma 10.2 S100B NF1
40 conventional fibrosarcoma 10.1 MYOD1 MB
41 plexiform neurofibroma 10.1 S100B NF1
42 malignant fibrous histiocytoma of bone 10.1 MYOD1 DES
43 chondrosarcoma 10.1
44 glomus tumor 10.1 TLE1 DES
45 epididymal neoplasm 10.1 NF1 MYOD1
46 childhood malignant schwannoma 10.1 NF1 MYOG
47 cavernous hemangioma 10.1 MB DES
48 congenital fibrosarcoma 10.1 MYOG DES
49 monophasic synovial sarcoma 10.1 TLE1 S100B
50 subungual glomus tumor 10.1 TLE1 NF1

Graphical network of the top 20 diseases related to Malignant Triton Tumor:



Diseases related to Malignant Triton Tumor

Symptoms & Phenotypes for Malignant Triton Tumor

MGI Mouse Phenotypes related to Malignant Triton Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DES MB MYOD1 MYOG NF1

Drugs & Therapeutics for Malignant Triton Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Triton Tumor

Genetic Tests for Malignant Triton Tumor

Anatomical Context for Malignant Triton Tumor

MalaCards organs/tissues related to Malignant Triton Tumor:

40
Small Intestine, Spinal Cord

Publications for Malignant Triton Tumor

Articles related to Malignant Triton Tumor:

(show top 50) (show all 126)
# Title Authors PMID Year
1
Loss of H3K27me3 occurs in a large subset of embryonal rhabdomyosarcomas: Immunohistochemical and molecular analysis of 25 cases. 61
33770660 2021
2
Malignant Glandular Triton Tumor Arising in the Radial Nerve with Prolonged Survival: A Case Report and Review of the Literature. 61
33791136 2021
3
Triton tumor of the orbit. 61
31746248 2020
4
Retroperitoneal malignant triton tumor in an infant: a case report and literature review. 61
32953555 2020
5
[Focus on oncologic safety and function: Primary defect reconstruction of a malignant Triton tumor of the sciatic nerve sheath with myocutaneous free flap surgery]. 61
32120413 2020
6
Elbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report. 61
32620140 2020
7
Malignant triton tumor below the peritoneal reflection: a case report. 61
32595924 2020
8
Worsening Hemoptysis in a Rare Intrapulmonary Triton Tumor Mimicking Lung Cancer. 61
31400331 2020
9
Malignant triton tumor of the rectum - A case report and review of the literature. 61
33207422 2020
10
Malignant Triton Tumor Diagnosed on Fine Needle Aspiration Cytology. 61
31741582 2019
11
A series of 10 malignant triton tumors in one institution. 61
31490366 2019
12
Malignant triton tumor of the left thoracic cavity: a case report. 61
31528328 2019
13
Malignant triton tumor diagnosed twelve years after radiosurgically treated vestibular schwannoma. 61
31176932 2019
14
Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor. 61
28924675 2019
15
Expert's comment concerning Grand Rounds case entitled "Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor" by S. Ghailane et al. (Eur Spine J; 2017: DOI 10.1007/s00586-017-5277-2). 61
29671111 2019
16
Teaching NeuroImages: Intracranial malignant triton tumor: An uncommon location of a rare tumor. 61
30886081 2019
17
Mediastinal malignant triton tumor: A rare case series and review of literature. 61
31494456 2019
18
Malignant Triton Tumor in a Child: Case Report and Literature Review. 61
31920385 2019
19
Malignant triton tumor of the gluteal region in a patient unaffected by neurofibromatosis: A case report. 61
29110923 2018
20
Malignant triton tumor of trigeminal nerve-case report. 61
29279963 2018
21
Malignant triton tumor of the duodenum: report of a case. 61
31149515 2018
22
A rare case of intracranial malignant triton tumor arising in the middle cranial fossa: a case report and review of the literature. 61
30509044 2018
23
[A Rare Case of Abdominal Malignant Triton Tumor]. 61
29394776 2017
24
Malignant Triton Tumor (Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation) Occurring in a Vascularized Free Flap Reconstruction Graft. 61
28387148 2017
25
A Case of Retroperitoneal Malignant Triton Tumor in a Nigerian Boy. 61
29089742 2017
26
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. 61
28884110 2017
27
Malignant triton tumor of the lung, infiltrating the left atrium and left ventricle, with metastasis to the small intestine. 61
28515751 2017
28
Malignant Triton Tumor of the Kidney. New Location Not Previously Reported. 61
26159374 2017
29
A case of recurrent malignant triton tumor successfully treated with radiotherapy. 61
27146005 2016
30
Insidious malignant triton tumor of the chest wall with late flare-up. 61
28757738 2016
31
Novel PAX3-NCOA1 Fusions in Biphenotypic Sinonasal Sarcoma With Focal Rhabdomyoblastic Differentiation. 61
26371783 2016
32
A rare case of recurrent malignant triton tumor in a male with NF1: Case report and mini-review. 61
26975033 2016
33
Analysis of clinical features and prognosis of malignant triton tumor: A report of two cases and literature review. 61
26788168 2015
34
Primary epididymis malignant triton tumor: case report and review of the literature. 61
26392076 2015
35
Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous and Glandular Elements: Rare Epithelial Differentiation in a Triton Tumor. 61
25911565 2015
36
Unusual histological variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. 61
25879014 2015
37
Malignant triton tumor of the cervical spine: report of one case and review of the literature. 61
23597523 2015
38
Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. 61
23633163 2014
39
Malignant triton tumor of the anterior mediastinum: A case report. 61
24527089 2014
40
Low-grade malignant triton tumor of the neck: a case report and review of the literature. 61
25328740 2014
41
Malignant Triton Tumor of the Sciatic Nerve as a Secondary Malignancy after Extended Field Radiotherapy and Chemotherapy of Hodgkin's Disease. 61
24803902 2014
42
Optimal surgical treatment and urological outcomes in boys with pelvic and urogenital rhabdomyosarcomas and soft tissue sarcomas. 61
23989524 2013
43
A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. 61
24474920 2013
44
Malignant triton tumor of the chest wall invading the lung. A case report and literature review. 61
24470743 2013
45
Malignant triton tumor: a rare case. 61
24426617 2013
46
Oncologic manifestations in children with neurofibromatosis type 1 in Turkey. 61
24217072 2013
47
A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. 61
23607247 2013
48
Intrathoracic malignant peripheral nerve sheath tumors: imaging features and implications for management. 61
24133387 2013
49
Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. 61
22610852 2012
50
A-Z of malignant peripheral nerve sheath tumors. 61
23108260 2012

Variations for Malignant Triton Tumor

Expression for Malignant Triton Tumor

Search GEO for disease gene expression data for Malignant Triton Tumor.

Pathways for Malignant Triton Tumor

Pathways related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.92 MYOG MYOD1
2 10.78 MYOG MYOD1 DES
3 10.64 TLE1 MYOD1

GO Terms for Malignant Triton Tumor

Cellular components related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 TLE1 MYOG MYOD1

Biological processes related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.49 MYOG MYOD1
2 skeletal muscle cell differentiation GO:0035914 9.48 MYOG MYOD1
3 cellular response to estradiol stimulus GO:0071392 9.46 MYOG MYOD1
4 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOG MYOD1
5 skeletal muscle fiber development GO:0048741 9.4 MYOG MYOD1
6 skeletal muscle tissue regeneration GO:0043403 9.37 MYOG MYOD1
7 positive regulation of myoblast differentiation GO:0045663 9.32 MYOG MYOD1
8 myoblast differentiation GO:0045445 9.26 MYOG MYOD1
9 myotube differentiation GO:0014902 9.16 MYOG MYOD1
10 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOG MYOD1
11 muscle cell fate commitment GO:0042693 8.62 MYOG MYOD1

Molecular functions related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 E-box binding GO:0070888 8.62 MYOG MYOD1

Sources for Malignant Triton Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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