MCID: MLG041
MIFTS: 35

Malignant Triton Tumor

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Malignant Triton Tumor

MalaCards integrated aliases for Malignant Triton Tumor:

Name: Malignant Triton Tumor 12 59 15
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcomatous Differenciation 59
Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation 73
Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma 12
Mpnst with Rhabdomyosarcomatous Differentiation 59
Mpnst with Rhabdomyoblastic Differentiation 12
Mpnst with Rhabdomyosarcoma 12
Malignant Triton Tumour 12
Mtt 59

Characteristics:

Orphanet epidemiological data:

59
malignant triton tumor
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6707
NCIt 50 C4335
Orphanet 59 ORPHA252212
UMLS via Orphanet 74 C0334616
UMLS 73 C0334616

Summaries for Malignant Triton Tumor

MalaCards based summary : Malignant Triton Tumor, also known as malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differenciation, is related to malignant peripheral nerve sheath tumor and neurofibroma. An important gene associated with Malignant Triton Tumor is MB (Myoglobin). The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include lung, small intestine and thyroid, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Malignant triton tumor (MTT) is a relatively rare, aggressive tumor made up of both malignant schwannoma... more...

Related Diseases for Malignant Triton Tumor

Diseases related to Malignant Triton Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 malignant peripheral nerve sheath tumor 31.3 NF1 S100B
2 neurofibroma 29.8 NF1 S100B
3 neurofibrosarcoma 11.5
4 breast rhabdomyosarcoma 10.3 DES MB
5 giant cell myocarditis 10.3 DES MB
6 botryoid rhabdomyosarcoma 10.3 DES MB
7 mesenchymoma 10.3 DES MB
8 myofibroma 10.3 DES MB
9 bilateral retinoblastoma 10.3 DES MB
10 adenosarcoma 10.3 DES MB
11 infantile myofibromatosis 10.2 DES MB
12 medullomyoblastoma 10.2 DES MB
13 malignant mesenchymoma 10.2 DES MB
14 uterine sarcoma 10.2 DES MB
15 glomangioma 10.2 DES MB
16 muscle cancer 10.2 DES MB
17 neurofibromatosis, type i 10.1
18 neurofibromatosis, type iv, of riccardi 10.1
19 pleuropulmonary blastoma 10.1 MB S100B
20 embryonal rhabdomyosarcoma 10.1 DES MB
21 ossifying fibromyxoid tumor 10.1 DES S100B
22 myxofibrosarcoma 10.1 DES S100B
23 syringocystadenoma papilliferum 10.1 DES S100B
24 alveolar soft part sarcoma 10.1 DES MB
25 syringoma 10.1 DES S100B
26 juvenile xanthogranuloma 10.1 DES S100B
27 pleomorphic liposarcoma 10.1 DES S100B
28 cutaneous fibrous histiocytoma 10.1 DES S100B
29 acute mountain sickness 10.1 MB S100B
30 spindle cell sarcoma 10.1 DES S100B
31 granular cell tumor 10.1 DES S100B
32 embryonal sarcoma 10.0 DES S100B
33 rhabdomyosarcoma 2 10.0 DES MB
34 hemangiopericytoma, malignant 10.0 DES S100B
35 malignant fibroxanthoma 10.0 DES S100B
36 leukemia 10.0
37 cervicitis 10.0
38 orbit embryonal rhabdomyosarcoma 10.0 MB NF1
39 orbit rhabdomyosarcoma 10.0 MB NF1
40 liposarcoma 10.0 DES MB
41 atypical teratoid rhabdoid tumor 9.9 DES S100B
42 gastric cancer 9.9
43 lymphoblastic leukemia 9.9
44 fibrous histiocytoma 9.9 DES S100B
45 dermatofibrosarcoma protuberans 9.9 DES S100B
46 pituitary adenoma 9.9
47 adenoma 9.9
48 endometrial stromal sarcoma 9.9 DES MB
49 inflammatory leiomyosarcoma 9.9 DES NF1
50 li-fraumeni syndrome 9.8

Graphical network of the top 20 diseases related to Malignant Triton Tumor:



Diseases related to Malignant Triton Tumor

Symptoms & Phenotypes for Malignant Triton Tumor

MGI Mouse Phenotypes related to Malignant Triton Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 DES MB NCOA1 NF1 S100B

Drugs & Therapeutics for Malignant Triton Tumor

Drugs for Malignant Triton Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Alkylating Agents Phase 2, Phase 3
8 Topoisomerase Inhibitors Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3
11 Antineoplastic Agents, Alkylating Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Malignant Triton Tumor

Genetic Tests for Malignant Triton Tumor

Anatomical Context for Malignant Triton Tumor

MalaCards organs/tissues related to Malignant Triton Tumor:

41
Lung, Small Intestine, Thyroid, Kidney, Spinal Cord

Publications for Malignant Triton Tumor

Articles related to Malignant Triton Tumor:

(show top 50) (show all 72)
# Title Authors Year
1
Expert's comment concerning Grand Rounds case entitled "Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor" by S. Ghailane et al. (Eur Spine J; 2017: DOI 10.1007/s00586-017-5277-2). ( 29671111 )
2018
2
Malignant triton tumor of the lung, infiltrating the left atrium and left ventricle, with metastasis to the small intestine. ( 28515751 )
2017
3
Malignant triton tumor of the gluteal region in a patient unaffected by neurofibromatosis: A case report. ( 29110923 )
2017
4
Malignant triton tumor of trigeminal nerve-case report. ( 29279963 )
2017
5
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
6
A Case of Retroperitoneal Malignant Triton Tumor in a Nigerian Boy. ( 29089742 )
2017
7
Malignant Triton Tumor (Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation) Occurring in a Vascularized Free Flap Reconstruction Graft. ( 28387148 )
2017
8
Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor. ( 28924675 )
2017
9
A rare case of recurrent malignant triton tumor in a male with NF1: Case report and mini-review. ( 26975033 )
2016
10
A case of recurrent malignant triton tumor successfully treated with radiotherapy. ( 27146005 )
2016
11
Insidious malignant triton tumor of the chest wall with late flare-up. ( 28757738 )
2016
12
Malignant Triton Tumor of the Kidney. New Location Not Previously Reported. ( 26159374 )
2015
13
Analysis of clinical features and prognosis of malignant triton tumor: A report of two cases and literature review. ( 26788168 )
2015
14
Primary epididymis malignant triton tumor: case report and review of the literature. ( 26392076 )
2015
15
Malignant triton tumor of the anterior mediastinum: A case report. ( 24527089 )
2014
16
Malignant Triton Tumor of the Sciatic Nerve as a Secondary Malignancy after Extended Field Radiotherapy and Chemotherapy of Hodgkin's Disease. ( 24803902 )
2014
17
Low-grade malignant triton tumor of the neck: a case report and review of the literature. ( 25328740 )
2014
18
A case of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation: malignant triton tumor. ( 24474920 )
2013
19
A rare case of retroperitoneal malignant Triton tumor invading renal vein and small intestine. ( 23607247 )
2013
20
Malignant triton tumor: a rare case. ( 24426617 )
2013
21
Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. ( 23633163 )
2013
22
Malignant Triton Tumor of Cervical Spine: Report of One Case and Review of the Literature. ( 23597523 )
2013
23
Malignant peripheral nerve sheath tumors: prognostic impact of rhabdomyoblastic differentiation (malignant triton tumors), neurofibromatosis 1 status and location. ( 23084090 )
2013
24
Malignant triton tumor of the chest wall invading the lung. A case report and literature review. ( 24470743 )
2013
25
Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. ( 21732991 )
2012
26
A rare case of malignant triton tumor in the cerebellopontine angle. ( 22515616 )
2012
27
Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X. ( 22610852 )
2012
28
Malignant triton tumor of the retroperitoneum: a case report and review of the literature. ( 22647059 )
2012
29
Treatment of malignant triton tumor in zygomatic region. ( 22627455 )
2012
30
Long-term survival of a patient with a neurofibromatosis Type 1 associated retroperitoneal malignant triton tumor after multi-modality treatment. ( 22011741 )
2011
31
Malignant triton tumor of cervical spine with hemorrhage. ( 21414786 )
2011
32
A Rare Malignant Triton Tumor. ( 20671860 )
2010
33
Intracardiac malignant Triton tumor: a first presentation. ( 20172170 )
2010
34
Pathology quiz case 1. Diagnosis: Sinonasal malignant Triton tumor (MTT) with intracranial extension. ( 20855691 )
2010
35
Malignant triton tumor of the infratemporal fossa. ( 19625850 )
2009
36
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
37
Malignant Triton tumor in the retroperitoneal space associated with neurofibromatosis type 1: a case study. ( 21139906 )
2009
38
Prognostic factors for the malignant triton tumor of the head and neck. ( 19283843 )
2009
39
A rare case of malignant triton tumor with pluridirectional differentiation. ( 19279515 )
2009
40
Hedgehog-Patched pathway aberrations in a malignant triton tumor case study. ( 18636196 )
2008
41
Malignant triton tumor in a patient with Li-Fraumeni syndrome and a novel TP53 mutation. ( 16333835 )
2007
42
Chemotherapy in metastatic malignant triton tumor: report on two cases. ( 17786333 )
2007
43
Malignant triton tumor of the pelvis in a 2-year-old boy. ( 16679944 )
2006
44
Malignant triton tumor (MTT) of the neck. ( 16185834 )
2006
45
Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). ( 17149968 )
2006
46
Malignant triton tumor presenting as a rectal mass in an 11-month-old. ( 15827834 )
2005
47
Malignant triton tumor of the lumbar spine. ( 15371720 )
2004
48
Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (malignant triton tumor) with balanced t(7;9)(q11.2;p24) and unbalanced translocation der(16)t(1;16)(q23;q13). ( 15104279 )
2004
49
Radiation-induced malignant triton tumor associated with severe spinal cord compression. Case report and review of the literature. ( 15029921 )
2004
50
Schwannoma with rhabdomyoblastic differentiation: a unique variant of malignant triton tumor. ( 12766593 )
2003

Variations for Malignant Triton Tumor

Expression for Malignant Triton Tumor

Search GEO for disease gene expression data for Malignant Triton Tumor.

Pathways for Malignant Triton Tumor

GO Terms for Malignant Triton Tumor

Biological processes related to Malignant Triton Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 8.96 MB NF1
2 positive regulation of apoptotic process GO:0043065 8.8 NCOA1 NF1 S100B

Sources for Malignant Triton Tumor

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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