MCID: MLG163
MIFTS: 30

Malignant Tumor of Penis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Malignant Tumor of Penis

MalaCards integrated aliases for Malignant Tumor of Penis:

Name: Malignant Tumor of Penis 59
Malignant Penile Tumor 59
Cancer of Penis 59
Penile Cancer 59

Characteristics:

Orphanet epidemiological data:

59
malignant tumor of penis
Prevalence: 1-9/100000 (Brazil),1-9/100000 (Uganda),1-9/100000 (Europe),1-9/100000 (United Kingdom),1-9/1000000 (United States); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare urogenital diseases


External Ids:

ICD10 via Orphanet 34 C60.0 C60.1 C60.2 more
UMLS via Orphanet 73 C0153601 C0853105
Orphanet 59 ORPHA398043

Summaries for Malignant Tumor of Penis

MalaCards based summary : Malignant Tumor of Penis, also known as malignant penile tumor, is related to penile cancer and penile cancer, adult. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and prostate.

Related Diseases for Malignant Tumor of Penis

Diseases related to Malignant Tumor of Penis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 penile cancer 12.9
2 penile cancer, adult 12.4
3 penile cancer, childhood 12.3
4 obsolete: hiv-related penile cancer 12.3
5 phimosis 10.5
6 squamous cell papilloma 10.5
7 papilloma 10.5
8 squamous cell carcinoma 10.3
9 rare tumor 10.3
10 in situ carcinoma 10.3
11 lichen sclerosus 10.3
12 verrucous carcinoma 10.3
13 cervical cancer 10.2
14 lymphocele 10.2
15 lymphedema 10.2
16 lymph node disease 10.2
17 anogenital venereal wart 10.1
18 neutropenia 10.1
19 balanitis 10.1
20 bowen's disease 10.1
21 sexual disorder 10.1
22 impotence 10.1
23 erythroplakia 10.1
24 urethral stricture 10.1
25 testicular cancer 10.1
26 penis squamous cell carcinoma 10.1
27 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
28 body mass index quantitative trait locus 1 10.0
29 mucositis 10.0
30 balanitis xerotica obliterans 10.0
31 mammary paget's disease 10.0
32 laurence-moon syndrome 9.9
33 body mass index quantitative trait locus 11 9.9
34 body mass index quantitative trait locus 9 9.9
35 body mass index quantitative trait locus 8 9.9
36 body mass index quantitative trait locus 4 9.9
37 body mass index quantitative trait locus 10 9.9
38 body mass index quantitative trait locus 7 9.9
39 body mass index quantitative trait locus 12 9.9
40 body mass index quantitative trait locus 14 9.9
41 body mass index quantitative trait locus 18 9.9
42 immunodeficiency, common variable, 10 9.9
43 body mass index quantitative trait locus 19 9.9
44 body mass index quantitative trait locus 20 9.9
45 exanthem 9.9
46 telangiectasis 9.9
47 balanoposthitis 9.9
48 post-traumatic stress disorder 9.9
49 angiokeratoma 9.9
50 acute stress disorder 9.9

Graphical network of the top 20 diseases related to Malignant Tumor of Penis:



Diseases related to Malignant Tumor of Penis

Symptoms & Phenotypes for Malignant Tumor of Penis

Drugs & Therapeutics for Malignant Tumor of Penis

Drugs for Malignant Tumor of Penis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Cola Phase 3
4 Liver Extracts Phase 3
5 Analgesics Phase 3
6 Anesthetics, Intravenous Phase 3
7 Narcotics Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Analgesics, Opioid Phase 3
10 Adjuvants, Anesthesia Phase 3
11 Central Nervous System Depressants Phase 3
12 Anesthetics, General Phase 3
13 Anesthetics Phase 3
14
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
15
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
16
Indinavir Approved Phase 2 150378-17-9 5362440
17
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
18
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
19
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
20
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
21
Pembrolizumab Approved Phase 2 1374853-91-4
22
nivolumab Approved Phase 1, Phase 2 946414-94-4
23 Daratumumab Approved Phase 1, Phase 2 945721-28-8
24
Ipilimumab Approved Phase 1, Phase 2 477202-00-9
25
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
26
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
27 HIV Protease Inhibitors Phase 2
28 Cytochrome P-450 CYP3A Inhibitors Phase 2
29
protease inhibitors Phase 2
30 Cytochrome P-450 Enzyme Inhibitors Phase 2
31 Anti-Retroviral Agents Phase 2
32 Anti-HIV Agents Phase 2
33 topoisomerase I inhibitors Phase 2
34 Topoisomerase Inhibitors Phase 2
35 Vaccines Phase 2
36 interferons Phase 2
37 Interferon-alpha Phase 2
38 Dermatologic Agents Phase 2
39 Anti-Infective Agents Phase 2
40 Antiviral Agents Phase 2
41 Antibodies Phase 2
42 Immunologic Factors Phase 2
43 Antibodies, Monoclonal Phase 2
44 Immunoglobulins Phase 2
45
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
46 Interferon-beta Phase 1
47 Antimetabolites Phase 1
48 Antimetabolites, Antineoplastic Phase 1
49 Adjuvants, Immunologic Phase 1
50 Freund's Adjuvant Phase 1

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Radiation Therapy in Combination With Indinavir / Ritonavir (Crixivan / Norvir) for the Treatment of Brain Metastases: a Randomized Phase II Study Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
3 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
4 A Phase II Trial of Cabazitaxel Chemotherapy in Relapsed Locally Advanced &/or Metastatic Carcinoma of the Penis Completed NCT03114254 Phase 2 Cabazitaxel
5 ALPHA INTERFERON AND CIS-RETINOIC ACID FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMAS Completed NCT00002506 Phase 2 isotretinoin
6 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
7 AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males Completed NCT01209325 Phase 2
8 PERICLES (PEnile Cancer Radio- and Immunotherapy CLinical Exploration Study)-a Phase 2 Study of Atezolizumab With or Without Radiotherapy in Penile Cancer Recruiting NCT03686332 Phase 2 Arm A: Atezolizumab and Radiotherapy;Arm B: Atezolizumab
9 A Phase 2, Multi-centre, Open-label Study of Avelumab (MSB0010718C) in Locally Advanced or Metastatic Penile Cancer Patients Unfit for Platinum-based Chemotherapy or Progressed On or After Platinum-based Chemotherapy Recruiting NCT03391479 Phase 2 Avelumab
10 Phase II Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Following Previous Chemotherapy Recruiting NCT02837042 Phase 2 Pembrolizumab
11 Activity and Tolerability of Maintenance Avelumab Immunotherapy After First Line Polychemotherapy Including Platinum in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Recruiting NCT03774901 Phase 2 Avelumab
12 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Recruiting NCT02817958 Phase 2 Chemotherapy TIP
13 Non-Comparative, Open-Label, Multiple Cohort, Phase 1/2 Study of Nivolumab Monotherapy and Nivolumab Combination Therapy in Subjects With Virus-Positive and Virus-Negative Solid Tumors Recruiting NCT02488759 Phase 1, Phase 2 Nivolumab;Ipilimumab;Relatlimab;Daratumumab
14 Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types Recruiting NCT03012581 Phase 2 Nivolumab
15 M7824 in Subjects With HPV Associated Malignancies Recruiting NCT03427411 Phase 2 M7824
16 Phase II Study Of Weekly Docetaxel In Patients With Advanced Epidermoid Carcinoma Of The Penis Terminated NCT00058448 Phase 2 docetaxel
17 Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
18 A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
19 A Phase I Clinical Trial of Intrapleural Adenoviral-Mediated Interferon-beta (IFN-ß) Gene Transfer for Pleural Malignancies Unknown status NCT00066404 Phase 1
20 Phase I Study of Oral Capecitabine (Xeloda) as a Radiation Enhancer in Locally Unresectable, Residual, or Recurrent Colorectal Cancer Localized in the Pelvis Completed NCT00003704 Phase 1 capecitabine
21 An Open Label, Sequential Cohort Dose-Escalation Safety, Tolerability and Pharmacokinetic Study of VEGF Trap Administered Intravenously in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00083213 Phase 1
22 An Open-Label, Long-Term, Safety and Tolerability Study of VEGF Trap Administered Intravenously in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00082823 Phase 1
23 VACCINE THERAPY AND DETECTION OF IMMUNOLOGIC RESPONSES WITH HUMAN PAPILLOMAVIRUS 16 E6 AND E7 PEPTIDES IN PATIENTS WITH METASTATIC OR LOCALLY ADVANCED CERVICAL CANCER Completed NCT00019110 Phase 1
24 Pilot Study on Concurrent Cisplatin-based Chemotherapy Combined With Vaccination Therapy With the P16_37-63 Peptide in Patients With HPV- and p16INK4a-positive Cancer Completed NCT02526316 Phase 1
25 A Multicenter Phase 1, Open-Label Study of DCC-2618 to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced Malignancies Recruiting NCT02571036 Phase 1 DCC-2618;DCC-2618
26 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
27 Comparative Effectiveness of Interactive, Health Literacy Promoting Text Messages on HPV Vaccine Completion In Minority Adolescents Completed NCT02236273
28 A Feasibility Study of PrePex Device for Infants and for Children, When Performed on Early Infants and Children Male Population by Physicians Completed NCT02281461
29 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302
30 Improving Palliative Care for Patients With Cancer Completed NCT00253383
31 Videoscopic Versus Open Inguinal Lymphadenectomy for Sentinel Node Positive Cutaneous Malignancies and Genitourinary Staging Procedures Completed NCT01526486
32 A Randomized Longitudinal Intervention Study to Assess Whether Electronic Messaging Can Increase HPV Vaccine Utilization and Adherence Among College Students in Eastern North Carolina. Completed NCT01568515 Early Phase 1
33 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients With Sentinel Lymph Nodes Determined to be Negative for Metastatic Disease. Completed NCT00315159
34 A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR) Completed NCT02337179
35 HPV-Related Oropharyngeal and Uncommon Cancers Screening Trial of meN (HOUSTON Study) Recruiting NCT02897427
36 Use of Laser Fluorescence With Spy Elite, Pinpoint and Firefly Robotic Platform Systems in Cancer Surgical Treatment Recruiting NCT03021200
37 Penile Allograft Transplantation for Men With Penile Loss After Ritual Circumcision Recruiting NCT03149692
38 A Randomized Trial of Pharmacological Penile Rehabilitation in the Preservation of Erectile Function Following Bilateral Nerve-Sparing Radical Prostatectomy Active, not recruiting NCT00955929 Placebo QHS and sildenafil and questionnaires;Sildenafil and questionnaire;Trimix combination (Papavarine 30mg/mL Phentholamine 1mg/mL Prostaglandin E1 10 mcg/mmL) and questionnaires

Search NIH Clinical Center for Malignant Tumor of Penis

Genetic Tests for Malignant Tumor of Penis

Anatomical Context for Malignant Tumor of Penis

MalaCards organs/tissues related to Malignant Tumor of Penis:

41
Lymph Node, Skin, Prostate, Brain, Liver, Testis, Bone

Publications for Malignant Tumor of Penis

Articles related to Malignant Tumor of Penis:

(show top 50) (show all 1432)
# Title Authors PMID Year
1
Treating advanced penile cancer: where do we stand in 2019? 38
31082941 2019
2
Mutational landscape of penile squamous cell carcinoma in a Chinese population. 38
31034097 2019
3
Adherence to guideline recommendations for lymph node dissection in squamous cell carcinoma of the penis: Effect on survival and complication rates. 38
31296420 2019
4
Surgical management of a rare case of giant penile cancer. 38
30421592 2019
5
Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study. 38
30377813 2019
6
Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management. 38
31409618 2019
7
Lifestyle in urology: Cancer. 38
31431169 2019
8
Urethral stricture and scrotal abscess: a rare case presentation of penile cancer and review of the literature. 38
31397610 2019
9
Familial Clustering, Second Primary Cancers and Causes of Death in Penile, Vulvar and Vaginal Cancers. 38
31413311 2019
10
Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma. 38
30972551 2019
11
Continuous Spatial Sequences of Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Invasive Carcinomas: A Study of 109 Cases. 38
30614356 2019
12
Organ-sparing procedures in GU cancer: part 2-organ-sparing procedures in testicular and penile tumors. 38
31267441 2019
13
The impact of health literacy on urologic oncology care. 38
31324457 2019
14
External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes. 38
31136111 2019
15
The relationship between human papillomavirus and penile cancer over the past decade: a systematic review and meta-analysis. 38
31134917 2019
16
Is there any benefit in adding postoperative adjuvant concurrent radiotherapy and chemotherapy for penile cancer with regional lymph node metastasis? 38
31353875 2019
17
Nineteen-year single-center experience in 76 patients with penile cancer treated with high-dose-rate brachytherapy. 38
31101437 2019
18
Editorial Comment: External validation of nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes. 38
31397988 2019
19
Magnetic Resonance Sentinel Lymph Node Imaging and Magnetometer-Guided Intraoperative Detection in Penile Cancer, using Superparamagnetic Iron Oxide Nanoparticles: First Results. 38
31357198 2019
20
[Molecular tumor board penile cancer-a challenge]. 38
31240374 2019
21
Making surgery safer by centralization of care: impact of case load in penile cancer. 38
31292733 2019
22
Updates in the molecular epidemiology and systemic approaches to penile cancer. 38
31053523 2019
23
The Prevalence of Penile Cancer in patients with Adult Acquired Buried Penis. 38
31369750 2019
24
Re: Racial Disparity and Survival Outcomes between African-American and Caucasian American Men with Penile Cancer. 38
31287362 2019
25
Genetics and penile cancer: recent developments and implications. 38
31045928 2019
26
Preoperative plasma IGFBP2 is associated with nodal metastasis in patients with penile squamous cell carcinoma. 38
31053522 2019
27
A National Cancer Database-based nomogram to predict lymph node metastasis in penile cancer. 38
30548161 2019
28
Neoadjuvant docetaxel, cisplatin and ifosfamide (ITP) combination chemotherapy for treating penile squamous cell carcinoma patients with terminal lymph node metastasis. 38
31238987 2019
29
The molecular pathogenesis of penile carcinoma-current developments and understanding. 38
31243533 2019
30
The International Penile Advanced Cancer Trial (InPACT): Rationale and Current Status. 38
31160252 2019
31
Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations. 38
31074361 2019
32
Comparison of clinical feasibility and oncological outcomes between video endoscopic and open inguinal lymphadenectomy for penile cancer: A systematic review and meta-analysis. 38
31145338 2019
33
Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival. 38
31062123 2019
34
Rare and less common tumours: urologists at the forefront of testicular and penile cancer. 38
31116004 2019
35
Management of the Clinically Negative (cN0) Groin Penile Cancer Patient: A Review. 38
31129195 2019
36
Survival Following Salvage Surgery after Failed Radiotherapy for Penile Cancer: A SEER-Based Study. 38
31316322 2019
37
Novel real-time optical imaging modalities for the detection of neoplastic lesions in urology: a systematic review. 38
30421080 2019
38
Impact of Centralizing Care for Genitourinary Malignancies to High-volume Providers: A Systematic Review. 38
31200840 2019
39
Large verrucous penis cancer in a young patient in the Brazilian Amazon: Case report and discussion on the region's reality. 38
31211068 2019
40
Important surgical concepts and techniques in inguinal lymph node dissection. 38
30730389 2019
41
The healthcare costs of treating human papillomavirus-related cancers in Norway. 38
31064346 2019
42
National Trends in Human Papillomavirus Awareness and Knowledge of Human Papillomavirus-Related Cancers. 38
30772151 2019
43
Re: Peter A.S. Johnstone, David Boulware, Rosa Djajadiningrat, et al. Primary Penile Cancer: The Role of Adjuvant Radiation Therapy in the Management of Extranodal Extension in Lymph Nodes. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2018.10.007. 38
30981672 2019
44
Reply to Vedang Murthy, Abhilash Gavarraju, and Rahul Krishnatry's Letter to the Editor re: Peter A.S. Johnstone, David Boulware, Rosa Djajadiningrat, et al. Primary Penile Cancer: The Role of Adjuvant Radiation Therapy in the Management of Extranodal Extension in Lymph Nodes. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2018.10.007. 38
31000494 2019
45
P53 and Survival Rate in Penile Cancer. 38
31049102 2019
46
Awareness and Knowledge Levels of 18-Year-Old and Older Individuals Regarding Human Papillomavirus (HPV) and HPV Vaccine in Hatay, Turkey. 38
29063507 2019
47
Penile Cancer Management in the United States: Regional Centers of Expertise are Needed! 38
30684158 2019
48
Penile cancer - Incidence, mortality, and survival in Saxony, Germany. 38
30595462 2019
49
Mean treatment cost of incident cases of penile cancer for privately insured patients in the United States. 38
30660492 2019
50
Evaluation of Paclitaxel, Ifosfamide, and Cisplatin (TIP) Regimen on Penile Cancer in Adam Malik Medan: A Single Center 2 Years of Experience. 38
31049098 2019

Variations for Malignant Tumor of Penis

Expression for Malignant Tumor of Penis

Search GEO for disease gene expression data for Malignant Tumor of Penis.

Pathways for Malignant Tumor of Penis

GO Terms for Malignant Tumor of Penis

Sources for Malignant Tumor of Penis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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