MCID: MLG163
MIFTS: 29

Malignant Tumor of Penis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Malignant Tumor of Penis

MalaCards integrated aliases for Malignant Tumor of Penis:

Name: Malignant Tumor of Penis 58
Malignant Penile Tumor 58
Cancer of Penis 58
Penile Cancer 58

Characteristics:

Orphanet epidemiological data:

58
malignant tumor of penis
Prevalence: 1-9/100000 (Brazil),1-9/100000 (Uganda),1-9/100000 (Europe),1-9/100000 (United Kingdom),1-9/1000000 (United States); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare urogenital diseases


External Ids:

ICD10 via Orphanet 33 C60.0 C60.1 C60.2 more
UMLS via Orphanet 72 C0153601 C0853105
Orphanet 58 ORPHA398043

Summaries for Malignant Tumor of Penis

MalaCards based summary : Malignant Tumor of Penis, also known as malignant penile tumor, is related to penile cancer and penile cancer, adult. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and prostate.

Related Diseases for Malignant Tumor of Penis

Diseases related to Malignant Tumor of Penis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 penile cancer 12.9
2 penile cancer, adult 12.4
3 obsolete: hiv-related penile cancer 12.3
4 phimosis 10.5
5 squamous cell papilloma 10.5
6 papilloma 10.5
7 squamous cell carcinoma 10.3
8 in situ carcinoma 10.3
9 rare tumor 10.3
10 lichen sclerosus et atrophicus 10.3
11 verrucous carcinoma 10.3
12 lymphocele 10.2
13 lymphedema 10.2
14 anogenital venereal wart 10.2
15 lymph node disease 10.2
16 cervical cancer 10.1
17 neutropenia 10.1
18 balanitis 10.1
19 bowen's disease 10.1
20 sexual disorder 10.1
21 impotence 10.1
22 erythroplakia 10.1
23 urethral stricture 10.1
24 testicular cancer 10.1
25 penis squamous cell carcinoma 10.1
26 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
27 body mass index quantitative trait locus 1 10.0
28 mucositis 10.0
29 balanitis xerotica obliterans 10.0
30 mammary paget's disease 10.0
31 laurence-moon syndrome 9.9
32 body mass index quantitative trait locus 11 9.9
33 body mass index quantitative trait locus 9 9.9
34 body mass index quantitative trait locus 8 9.9
35 body mass index quantitative trait locus 4 9.9
36 body mass index quantitative trait locus 10 9.9
37 body mass index quantitative trait locus 7 9.9
38 body mass index quantitative trait locus 12 9.9
39 body mass index quantitative trait locus 14 9.9
40 body mass index quantitative trait locus 18 9.9
41 body mass index quantitative trait locus 19 9.9
42 body mass index quantitative trait locus 20 9.9
43 exanthem 9.9
44 telangiectasis 9.9
45 balanoposthitis 9.9
46 post-traumatic stress disorder 9.9
47 angiokeratoma 9.9
48 acute stress disorder 9.9
49 herpes simplex 9.9
50 leukoplakia of penis 9.9

Graphical network of the top 20 diseases related to Malignant Tumor of Penis:



Diseases related to Malignant Tumor of Penis

Symptoms & Phenotypes for Malignant Tumor of Penis

Drugs & Therapeutics for Malignant Tumor of Penis

Drugs for Malignant Tumor of Penis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Cola Phase 3
4 Liver Extracts Phase 3
5 Narcotics Phase 3
6 Anesthetics Phase 3
7 Anesthetics, General Phase 3
8 Analgesics, Opioid Phase 3
9 Adjuvants, Anesthesia Phase 3
10 Central Nervous System Depressants Phase 3
11 Anesthetics, Intravenous Phase 3
12 Analgesics Phase 3
13
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
14
Indinavir Approved Phase 2 150378-17-9 5362440
15
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
16
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
17
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
18
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
19
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
20
Pembrolizumab Approved Phase 2 1374853-91-4
21
nivolumab Approved Phase 1, Phase 2 946414-94-4
22
Ipilimumab Approved Phase 1, Phase 2 477202-00-9
23 Daratumumab Approved Phase 1, Phase 2 945721-28-8
24
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
25
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
26
protease inhibitors Phase 2
27 HIV Protease Inhibitors Phase 2
28 Cytochrome P-450 CYP3A Inhibitors Phase 2
29 Cytochrome P-450 Enzyme Inhibitors Phase 2
30 Anti-Retroviral Agents Phase 2
31 Anti-HIV Agents Phase 2
32 topoisomerase I inhibitors Phase 2
33 Topoisomerase Inhibitors Phase 2
34 interferons Phase 2
35 Anti-Infective Agents Phase 2
36 Antiviral Agents Phase 2
37 Dermatologic Agents Phase 2
38 Interferon-alpha Phase 2
39 Antibodies, Monoclonal Phase 2
40 Immunoglobulins Phase 2
41 Immunologic Factors Phase 2
42 Antibodies Phase 2
43 Vaccines Phase 1, Phase 2
44
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
45
Entinostat Investigational Phase 1 209783-80-2
46 Interferon-beta Phase 1
47 Antimetabolites Phase 1
48 Histone Deacetylase Inhibitors Phase 1
49 Adjuvants, Immunologic Phase 1
50 Freund's Adjuvant Phase 1

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Radiation Therapy in Combination With Indinavir / Ritonavir (Crixivan / Norvir) for the Treatment of Brain Metastases: a Randomized Phase II Study Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
3 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
4 A Phase II Trial of Cabazitaxel Chemotherapy in Relapsed Locally Advanced &/or Metastatic Carcinoma of the Penis Completed NCT03114254 Phase 2 Cabazitaxel
5 ALPHA INTERFERON AND CIS-RETINOIC ACID FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMAS Completed NCT00002506 Phase 2 isotretinoin
6 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
7 AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males Completed NCT01209325 Phase 2
8 PERICLES (PEnile Cancer Radio- and Immunotherapy CLinical Exploration Study)-a Phase 2 Study of Atezolizumab With or Without Radiotherapy in Penile Cancer Recruiting NCT03686332 Phase 2 Arm A: Atezolizumab and Radiotherapy;Arm B: Atezolizumab
9 A Phase 2, Multi-centre, Open-label Study of Avelumab (MSB0010718C) in Locally Advanced or Metastatic Penile Cancer Patients Unfit for Platinum-based Chemotherapy or Progressed On or After Platinum-based Chemotherapy Recruiting NCT03391479 Phase 2 Avelumab
10 Activity and Tolerability of Maintenance Avelumab Immunotherapy After First Line Polychemotherapy Including Platinum in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Recruiting NCT03774901 Phase 2 Avelumab
11 Phase II Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Following Previous Chemotherapy Recruiting NCT02837042 Phase 2 Pembrolizumab
12 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Recruiting NCT02817958 Phase 2 Chemotherapy TIP
13 Non-Comparative, Open-Label, Multiple Cohort, Phase 1/2 Study of Nivolumab Monotherapy and Nivolumab Combination Therapy in Subjects With Virus-Positive and Virus-Negative Solid Tumors Recruiting NCT02488759 Phase 1, Phase 2 Nivolumab;Ipilimumab;Relatlimab;Daratumumab
14 Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types Recruiting NCT03012581 Phase 2 Nivolumab
15 M7824 in Subjects With HPV Associated Malignancies Recruiting NCT03427411 Phase 2 M7824
16 A Phase I/II Study of HB-201 Monotherapy or in Combination With Checkpoint Inhibitors in Patients With Human Papillomavirus 16 Positive (HPV 16+) Confirmed Cancers' Not yet recruiting NCT04180215 Phase 1, Phase 2 HB-201 intravenous administration;HB-201 intratumoral administration on first cycle, followed by HB-201 intravenous administration on subsequent cycles
17 Phase II Study Of Weekly Docetaxel In Patients With Advanced Epidermoid Carcinoma Of The Penis Terminated NCT00058448 Phase 2 docetaxel
18 Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
19 A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
20 A Phase I Clinical Trial of Intrapleural Adenoviral-Mediated Interferon-beta (IFN-ß) Gene Transfer for Pleural Malignancies Unknown status NCT00066404 Phase 1
21 Phase I Study of Oral Capecitabine (Xeloda) as a Radiation Enhancer in Locally Unresectable, Residual, or Recurrent Colorectal Cancer Localized in the Pelvis Completed NCT00003704 Phase 1 capecitabine
22 An Open Label, Sequential Cohort Dose-Escalation Safety, Tolerability and Pharmacokinetic Study of VEGF Trap Administered Intravenously in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00083213 Phase 1
23 An Open-Label, Long-Term, Safety and Tolerability Study of VEGF Trap Administered Intravenously in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00082823 Phase 1
24 VACCINE THERAPY AND DETECTION OF IMMUNOLOGIC RESPONSES WITH HUMAN PAPILLOMAVIRUS 16 E6 AND E7 PEPTIDES IN PATIENTS WITH METASTATIC OR LOCALLY ADVANCED CERVICAL CANCER Completed NCT00019110 Phase 1
25 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
26 Pilot Study on Concurrent Cisplatin-based Chemotherapy Combined With Vaccination Therapy With the P16_37-63 Peptide in Patients With HPV- and p16INK4a-positive Cancer Completed NCT02526316 Phase 1
27 A Multicenter Phase 1, Open-Label Study of DCC-2618 to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced Malignancies Recruiting NCT02571036 Phase 1 DCC-2618;DCC-2618
28 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
29 Comparative Effectiveness of Interactive, Health Literacy Promoting Text Messages on HPV Vaccine Completion In Minority Adolescents Completed NCT02236273
30 A Feasibility Study of PrePex Device for Infants and for Children, When Performed on Early Infants and Children Male Population by Physicians Completed NCT02281461
31 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302
32 Improving Palliative Care for Patients With Cancer Completed NCT00253383
33 Videoscopic Versus Open Inguinal Lymphadenectomy for Sentinel Node Positive Cutaneous Malignancies and Genitourinary Staging Procedures Completed NCT01526486
34 A Randomized Longitudinal Intervention Study to Assess Whether Electronic Messaging Can Increase HPV Vaccine Utilization and Adherence Among College Students in Eastern North Carolina. Completed NCT01568515 Early Phase 1
35 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients With Sentinel Lymph Nodes Determined to be Negative for Metastatic Disease. Completed NCT00315159
36 A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR) Completed NCT02337179
37 HPV-Related Oropharyngeal and Uncommon Cancers Screening Trial of meN (HOUSTON Study) Recruiting NCT02897427
38 Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease Recruiting NCT00026884
39 Use of Laser Fluorescence With Spy Elite, Pinpoint and Firefly Robotic Platform Systems in Cancer Surgical Treatment Recruiting NCT03021200
40 Penile Allograft Transplantation for Men With Penile Loss After Ritual Circumcision Recruiting NCT03149692
41 A Randomized Trial of Pharmacological Penile Rehabilitation in the Preservation of Erectile Function Following Bilateral Nerve-Sparing Radical Prostatectomy Active, not recruiting NCT00955929 Placebo QHS and sildenafil and questionnaires;Sildenafil and questionnaire;Trimix combination (Papavarine 30mg/mL Phentholamine 1mg/mL Prostaglandin E1 10 mcg/mmL) and questionnaires

Search NIH Clinical Center for Malignant Tumor of Penis

Genetic Tests for Malignant Tumor of Penis

Anatomical Context for Malignant Tumor of Penis

MalaCards organs/tissues related to Malignant Tumor of Penis:

40
Lymph Node, Skin, Prostate, Brain, Liver, Testis, Bone

Publications for Malignant Tumor of Penis

Articles related to Malignant Tumor of Penis:

(show top 50) (show all 1471)
# Title Authors PMID Year
1
Human papillomavirus vaccination and prevention of intraepithelial neoplasia and penile cancer: review article. 61
31972636 2020
2
An update on systemic therapy for penile cancer. 61
31972637 2020
3
Editorial Comment: A modified clinicopathological tumor staging system for survival prediction of patients with penile cancer. 61
32022521 2020
4
Editorial: Updates on penile cancer management: where do we stand, and how to move forward? 61
31905175 2020
5
Neoadjuvant chemotherapy for lymph node-positive penile cancer: current evidence and knowledge. 61
31913205 2020
6
Risk factors and molecular characterization of penile cancer: impact on prognosis and potential targets for systemic therapy. 61
31895076 2020
7
Neoadjuvant chemotherapy and penile conservation in the management of Buschke - Lowenstein tumor, a case report. 61
31908967 2020
8
Localized disease: types of reconstruction/plastic surgery techniques after glans resurfacing/glansectomy/partial/total penectomy. 61
31895889 2020
9
Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival. 61
31062123 2020
10
[Penile cancer : Diagnosis and treatment]. 61
32020240 2020
11
Systematic Review and Meta-Analysis: Is There a Benefit in Using Neoadjuvant Systemic Chemotherapy in Locally Advanced Penile Squamous Cell Carcinoma? 61
31928407 2020
12
Prevalence of Phimosis in Males of All Ages: Systematic Review. 61
31655079 2020
13
Short-Term Surgical Outcomes of Standard and Lateral Video Endoscopic Inguinal Lymphadenectomy: A Multinational Retrospective Study. 61
31928389 2020
14
Structural Analysis of the Bulbospongiosus Muscle in Patients With Bulbar Urethral Strictures. 61
31926195 2020
15
Urologic Conditions in Infants and Children: Circumcision. 61
31894950 2020
16
Management of clinically node-negative groin in patients with penile cancer. 61
31983820 2020
17
High-dose-rate brachytherapy for localized penile cancer: Evolution of a technique. 61
31959520 2020
18
[Penile cancer in Mexico: Twenty years experience at a tertiary academic hospital.] 61
31950918 2020
19
Role of MRI in Staging of Penile Cancer. 61
31976600 2020
20
Robot-assisted laparoscopic antegrade versus open inguinal lymphadenectomy: a retrospective controlled study. 61
31870347 2019
21
Histopathological risk scoring system as a tool for predicting lymph nodal metastasis in penile squamous cell carcinoma. 61
31635947 2019
22
Nail squamous cell carcinoma: A hidden high-risk human papillomavirus reservoir for sexually transmitted infections. 61
30930083 2019
23
[Glandectomy with cutaneous thigh graft]. 61
31899188 2019
24
[Video endoscopic inguinal lymphadenectomy in penile cancer: Systematic review.] 61
31823847 2019
25
Re: Risks and Benefits of Adjuvant Radiotherapy after Inguinal Lymphadenectomy in Node-Positive Penile Cancer: A Systematic Review by the European Association of Urology Penile Cancer Guidelines Panel. 61
31532294 2019
26
Competing-risks model for predicting the prognosis of penile cancer based on the SEER database. 61
31657120 2019
27
Adherence to the EAU guideline recommendations for systemic chemotherapy in penile cancer: results of the E-PROPS study group survey. 61
31834472 2019
28
Testing the Feasibility of SentiMag/Sienna+ for Detecting Inguinal Sentinel Nodes in Penile Cancer (SentiPen): An eUROGEN and National Cancer Research Institute Trial. 61
31570235 2019
29
Sentinel Node Mapping in Gynecologic Cancers: A Comprehensive Review. 61
31630736 2019
30
Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Penile Squamous Cell Carcinoma Patients Undergoing Inguinal Lymph Node Dissection. 61
29937330 2019
31
Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer. 61
31516836 2019
32
Re: Sarah R. Ottenhof, Andrew Leone, Rosa S. Djajadiningrat, et al. Surgical and Oncological Outcomes in Patients After Vascularized Flap Reconstruction for Locoregionally Advanced Penile Cancer. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2018.02.002. 61
29674120 2019
33
Use of Femostop device in the setting of life threatening inguinal bleeding. 61
31787442 2019
34
Intrinsic radiosensitivity, genomic-based radiation dose and patterns of failure of penile cancer in response to adjuvant radiation therapy. 61
31719799 2019
35
Penile strangulation intentionally using a rubber band to prevent the development of penile cancer. 61
31467859 2019
36
[Knowledge of German-speaking urologists regarding the association between penile cancer and human papilloma virus: results of a survey of the European PROspective Penile Cancer Study (E-PROPS)]. 61
31745963 2019
37
Optical biopsy of penile cancer with in vivo confocal laser endomicroscopy. 61
31537485 2019
38
The Prevalence of Penile Cancer in Patients With Adult Acquired Buried Penis. 61
31369750 2019
39
Organ-sparing procedures in GU cancer: part 2-organ-sparing procedures in testicular and penile tumors. 61
31267441 2019
40
A novel 'Batman' scrotectomy technique for the management of scrotal lymphoedema following treatment for penile cancer. 61
31807422 2019
41
Diagnostic precision of sentinel lymph node biopsy in penile cancer. 61
31619867 2019
42
Re: Racial Disparity and Survival Outcomes between African-American and Caucasian American Men with Penile Cancer. 61
31287362 2019
43
The molecular pathogenesis of penile carcinoma-current developments and understanding. 61
31243533 2019
44
Prognosis of the 8th TNM Staging System for Penile Cancer and Refinement of Prognostication by Incorporating High Risk Human Papillomavirus Status. 61
31596650 2019
45
Non-coding RNAs as biomarkers in liquid biopsies with a special emphasis on extracellular vesicles in urological malignancies. 61
31499007 2019
46
Mutational landscape of penile squamous cell carcinoma in a Chinese population. 61
31034097 2019
47
Adherence to guideline recommendations for lymph node dissection in squamous cell carcinoma of the penis: Effect on survival and complication rates. 61
31296420 2019
48
[Role of p16(INK4A) in detection of human papillomavirus DNA and stratification of cancer-specific mortality on the basis of long term follow-up data of 34 patients with invasive penile cancer]. 61
30227445 2019
49
The International Penile Advanced Cancer Trial (InPACT): Rationale and Current Status. 61
31160252 2019
50
Surgical and Oncological Outcomes in Patients After Vascularised Flap Reconstruction for Locoregionally Advanced Penile Cancer. 61
29433986 2019

Variations for Malignant Tumor of Penis

Expression for Malignant Tumor of Penis

Search GEO for disease gene expression data for Malignant Tumor of Penis.

Pathways for Malignant Tumor of Penis

GO Terms for Malignant Tumor of Penis

Sources for Malignant Tumor of Penis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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