MCID: MLG163
MIFTS: 29

Malignant Tumor of Penis

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Malignant Tumor of Penis

MalaCards integrated aliases for Malignant Tumor of Penis:

Name: Malignant Tumor of Penis 58
Malignant Penile Tumor 58
Cancer of Penis 58
Penile Cancer 58

Characteristics:

Orphanet epidemiological data:

58
malignant tumor of penis
Prevalence: 1-9/100000 (Brazil),1-9/100000 (Uganda),1-9/100000 (Europe),1-9/100000 (United Kingdom),1-9/1000000 (United States); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare urogenital diseases


External Ids:

ICD10 via Orphanet 33 C60.0 C60.1 C60.2 more
UMLS via Orphanet 71 C0153601 C0853105
Orphanet 58 ORPHA398043

Summaries for Malignant Tumor of Penis

MalaCards based summary : Malignant Tumor of Penis, also known as malignant penile tumor, is related to penile cancer and human papillomavirus infectious disease. The drugs Irinotecan and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, cervix and prostate.

Related Diseases for Malignant Tumor of Penis

Diseases related to Malignant Tumor of Penis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 penile cancer 11.8
2 human papillomavirus infectious disease 11.1
3 phimosis 10.6
4 squamous cell papilloma 10.6
5 papilloma 10.6
6 rare tumor 10.4
7 penile benign neoplasm 10.4
8 in situ carcinoma 10.4
9 lichen sclerosus et atrophicus 10.3
10 squamous cell carcinoma 10.3
11 hereditary lymphedema i 10.3
12 verrucous carcinoma 10.3
13 lymph node disease 10.3
14 lymphocele 10.3
15 anogenital venereal wart 10.2
16 sexual disorder 10.2
17 neutropenia 10.2
18 balanitis 10.2
19 impotence 10.2
20 penis squamous cell carcinoma 10.2
21 bowen's disease 10.1
22 erythroplakia 10.1
23 urethral stricture 10.1
24 testicular cancer 10.1
25 body mass index quantitative trait locus 1 10.0
26 mucositis 10.0
27 telangiectasis 10.0
28 balanitis xerotica obliterans 10.0
29 melanoma 10.0
30 mammary paget's disease 10.0
31 renal cell carcinoma, nonpapillary 9.9
32 laurence-moon syndrome 9.9
33 cervical cancer 9.9
34 exanthem 9.9
35 balanoposthitis 9.9
36 post-traumatic stress disorder 9.9
37 basal cell carcinoma 9.9
38 germ cell cancer 9.9
39 skin disease 9.9
40 angiokeratoma 9.9
41 basaloid squamous cell carcinoma 9.9
42 testicular germ cell cancer 9.9
43 acute stress disorder 9.9
44 leukoplakia of penis 9.9
45 bestiality 9.9
46 47,xyy 9.9
47 bowenoid papulosis 9.9
48 cervix carcinoma 9.9
49 bladder cancer 9.8
50 epidermoid cysts 9.8

Graphical network of the top 20 diseases related to Malignant Tumor of Penis:



Diseases related to Malignant Tumor of Penis

Symptoms & Phenotypes for Malignant Tumor of Penis

Drugs & Therapeutics for Malignant Tumor of Penis

Drugs for Malignant Tumor of Penis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
2
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
3
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
4
Ifosfamide Approved Phase 2 3778-73-2 3690
5
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
6
Fluorouracil Approved Phase 2 51-21-8 3385
7
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
8
Pembrolizumab Approved Phase 2 1374853-91-4
9
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
10
Nimotuzumab Investigational Phase 2 780758-10-3, 828933-61-3
11 Vaccines Phase 2
12 topoisomerase I inhibitors Phase 2
13
Isophosphamide mustard Phase 2 100427
14 Albumin-Bound Paclitaxel Phase 2
15 Immunologic Factors Phase 2
16 Immunoglobulins Phase 2
17 Antibodies Phase 2
18 Antibodies, Monoclonal Phase 2
19 Immunoglobulins, Intravenous Phase 2
20 Alkylating Agents Phase 2
21 Antineoplastic Agents, Immunological Phase 2
22 Tubulin Modulators Phase 2
23 Antimitotic Agents Phase 2
24 Adjuvants, Immunologic Phase 1
25 Freund's Adjuvant Phase 1
26
Papaverine Approved, Investigational 58-74-2, 61-25-6 4680
27
Alprostadil Approved, Investigational 745-65-3 149351 5280723
28
Sodium citrate Approved, Investigational 68-04-2
29
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
30 Vasodilator Agents
31 Citrate
32 Phosphodiesterase Inhibitors
33 Sildenafil Citrate 171599-83-0
34 Phosphodiesterase 5 Inhibitors
35 Platelet Aggregation Inhibitors

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males Completed NCT01209325 Phase 2
2 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
3 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
4 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Recruiting NCT02817958 Phase 2 Chemotherapy TIP
5 PERICLES (PEnile Cancer Radio- and Immunotherapy CLinical Exploration Study)-a Phase 2 Study of Atezolizumab With or Without Radiotherapy in Penile Cancer Recruiting NCT03686332 Phase 2 Arm A: Atezolizumab and Radiotherapy;Arm B: Atezolizumab
6 A Multicenter, Open-Label, Single-Arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of INCMGA00012 in Advanced Penile Squamous Cell Carcinoma. Recruiting NCT04231981 Phase 2 INCMGA0012
7 A Phase 2, Multi-centre, Open-label Study of Avelumab (MSB0010718C) in Locally Advanced or Metastatic Penile Cancer Patients Unfit for Platinum-based Chemotherapy or Progressed On or After Platinum-based Chemotherapy Recruiting NCT03391479 Phase 2 Avelumab
8 Activity and Tolerability of Maintenance Avelumab Immunotherapy After First Line Polychemotherapy Including Platinum in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Recruiting NCT03774901 Phase 2 Avelumab
9 A Single Center and Single Arm Study of TIP (Paclitaxel + Ifosfamide + Cisplatin) Combined With Nimotuzumab & Triprilimab as Neoadjuvant Treatment in Locally Advanced Penile Cancer Recruiting NCT04475016 Phase 2 Albumin-Bound Paclitaxel;Ifosfamide;Cisplatin;Nimotuzumab;Triprilimab
10 A Phase II Trial of Pembrolizumab Combined With Cisplatin-based Chemotherapy as First-line Systemic Therapy in Advanced Penile Cancer: LACOG 0218 HERCULES Trial Recruiting NCT04224740 Phase 2 Pembrolizumab;Standard of care therapy
11 Phase II Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Following Previous Chemotherapy Terminated NCT02837042 Phase 2 Pembrolizumab
12 Phase II Study Of Weekly Docetaxel In Patients With Advanced Epidermoid Carcinoma Of The Penis Terminated NCT00058448 Phase 2 docetaxel
13 Pilot Study on Concurrent Cisplatin-based Chemotherapy Combined With Vaccination Therapy With the P16_37-63 Peptide in Patients With HPV- and p16INK4a-positive Cancer Completed NCT02526316 Phase 1
14 A Multicenter Phase 1, Open-Label Study of DCC-2618 to Assess Safety, Tolerability, and Pharmacokinetics in Patients With Advanced Malignancies Recruiting NCT02571036 Phase 1 DCC-2618;DCC-2618
15 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
16 Videoscopic Versus Open Inguinal Lymphadenectomy for Sentinel Node Positive Cutaneous Malignancies and Genitourinary Staging Procedures Completed NCT01526486
17 A Randomized Trial of Pharmacological Penile Rehabilitation in the Preservation of Erectile Function Following Bilateral Nerve-Sparing Radical Prostatectomy Completed NCT00955929 Placebo QHS and sildenafil and questionnaires;Sildenafil and questionnaire;Trimix combination (Papavarine 30mg/mL Phentholamine 1mg/mL Prostaglandin E1 10 mcg/mmL) and questionnaires

Search NIH Clinical Center for Malignant Tumor of Penis

Genetic Tests for Malignant Tumor of Penis

Anatomical Context for Malignant Tumor of Penis

MalaCards organs/tissues related to Malignant Tumor of Penis:

40
Lymph Node, Cervix, Prostate, Testis, Neutrophil, Skin, Eye

Publications for Malignant Tumor of Penis

Articles related to Malignant Tumor of Penis:

(show top 50) (show all 1654)
# Title Authors PMID Year
1
Erectile function after partial penectomy for penile cancer. 61
33620995 2021
2
Salvage therapy for localized recurrences of penile cancer. 61
33742976 2021
3
Editorial Comment: Erectile function after partial penectomy for penile cancer. 61
33620996 2021
4
A Lack of Palliative Therapy Use in Patients With Advanced Penile Cancer. 61
32752928 2021
5
Editorial Comment to Human papilloma virus prevalence in penile cancer: A multicenter study from Denmark (DaPeCa-6). 61
33745211 2021
6
Surgical outcomes of glansectomy and split thickness skin graft reconstruction for localized penile cancer. 61
33811978 2021
7
Management of Advanced Penile Cancer. 61
33308870 2021
8
[Palliative needs of advanced penile cancer in a nonagenarian patient]. 61
33441240 2021
9
Pembrolizumab for advanced penile cancer: a case series from a phase II basket trial. 61
33770291 2021
10
Discrepancy of p16 immunohistochemical expression and HPV RNA in penile cancer. A multiplex in situ hybridization/immunohistochemistry approach study. 61
33789689 2021
11
[Penile Cancer: A case for non-lymph node disease following a negative sentinel node exploration.] 61
33650543 2021
12
Reply to Christian Daniel Fankhauser, Arie Parnham, Vijay Sangar's Letter to the Editor re: Paolo Dell'Oglio, Hielke M. de Vries, Elio Mazzone, et al. Hybrid Indocyanine Green-99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution. Eur Urol 2020;78:865-72. 61
33436166 2021
13
Lessons learned from histological step-sectioning of sentinel lymph nodes in penile cancer. 61
32979281 2021
14
High-dose rate brachytherapy in localized penile cancer: 5-Year clinical outcome analysis. 61
33537466 2021
15
Current and future vaccine clinical research with the licensed 2-, 4-, and 9-valent VLP HPV vaccines: What's ongoing, what's needed? 61
33678229 2021
16
Re: Paolo Dell'Oglio, Hielke M. de Vries, Elio Mazzone, et al. Hybrid Indocyanine Green-99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution. Eur Urol 2020;78:865-72. 61
33402294 2021
17
Current practice patterns of society of urologic oncology members in performing inguinal lymph node staging/therapy for penile cancer: A survey study. 61
33775532 2021
18
Management of penile cancer patients during the COVID-19 pandemic: An eUROGEN accelerated Delphi consensus study. 61
33397593 2021
19
Methodology for triage of urologic surgical cases in the setting of a pandemic. 61
33676485 2021
20
Blood-based biomarkers of human papillomavirus-associated cancers: A systematic review and meta-analysis. 61
33270909 2021
21
F-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography Has High Diagnostic Value for Pelvic and Distant Staging in Patients with High-risk Penile Carcinoma. 61
33685842 2021
22
A population-level analysis of nonsquamous penile cancer: The importance of histology. 61
33257222 2021
23
Lichen Sclerosus and Phimosis - Discrepancies Between Clinical and Pathological Diagnosis and Its Consequences. 61
33248142 2021
24
Update on organ preserving surgical strategies for penile cancer. 61
33610446 2021
25
Prognostic Factors in Penile Cancer: Should We Avoid Inguinal Lymph Node Staging? 61
33601381 2021
26
Is There an Oncological Benefit of Performing Bilateral Pelvic Lymph Node Dissection in Patients with Penile Cancer and Inguinal Lymph Node Metastasis? 61
33668548 2021
27
Re: Falcone et al.: Total Glans Resurfacing for the Management of Superficial Penile Cancer: A Retrospective Cohort Analysis in a Tertiary Referral Center (Urology 2020;145:281-286). 61
33359491 2021
28
A novel predictive model for pelvic lymph node metastasis in patients with penile cancer: A multi-institutional study. 61
33622619 2021
29
[Quality of care criteria in the treatment of penile cancer]. 61
33452551 2021
30
DaPeCa-8: drawing the map of lymphatic drainage in patients with invasive penile cancer - evidence from SPECT/CT and sentinel node surgery. 61
33569972 2021
31
Penile cancer. 61
33574296 2021
32
Penile cancer. 61
33574340 2021
33
Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure. 61
32372159 2021
34
Phallus Preservation in Penile Cancer Surgery: Patient-reported Aesthetic & Functional Outcomes. 61
33600836 2021
35
Expansion of tumor-infiltrating lymphocytes (TIL) from penile cancer patients. 61
33636562 2021
36
Penile preserving surgery in penile cancer management. 61
33733263 2021
37
Contemporary Incidence and Predictors of Occult Inguinal Lymph Node Metastases in Men With Clinically Node-negative (cN0) Penile Cancer. 61
33636210 2021
38
DaPeCa-7: comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer. 61
33448605 2021
39
DaPeCa-9 - cohabitation and socio-economic conditions predict penile cancer-specific survival in a national clinical study from Denmark. 61
33554693 2021
40
Adjuvant radiotherapy for node-positive penile cancer. 61
33462422 2021
41
The HPV and p63 Status in Penile Cancer Are Linked with the Infiltration and Therapeutic Availability of Neutrophils. 61
33273057 2021
42
Urethral cancer managed with phallus preserving surgery: a case report. 61
33608031 2021
43
Oncologic outcomes and subsequent treatment following organ sparing surgery for penile carcinoma: The University of Texas M.D. Anderson Cancer Center Experience. 61
33612354 2021
44
[Cancers of the external genital organs of male in Hérault: Results from the Hérault tumor register (RTH) over a period of 30 years (1987-2016)]. 61
33593695 2021
45
Experimental Models for Studying HPV-Positive and HPV-Negative Penile Cancer: New Tools for An Old Disease. 61
33530343 2021
46
Serum CXCL5 level is associated with tumor progression in penile cancer. 61
33458757 2021
47
Oncological therapy to Swedish men with metastatic penile cancer 2000-2015. 61
33030399 2021
48
Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature. 61
33454930 2021
49
Reply to Vedang Murthy, Abhilash Gavarraju, and Rahul Krishnatry's Letter to the Editor re: Peter A.S. Johnstone, David Boulware, Rosa Djajadiningrat, et al. Primary Penile Cancer: The Role of Adjuvant Radiation Therapy in the Management of Extranodal Extension in Lymph Nodes. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2018.10.007. 61
31000494 2021
50
Case report: Penile cancer treated by Mohs micrographic surgery. 61
33102127 2021

Variations for Malignant Tumor of Penis

Expression for Malignant Tumor of Penis

Search GEO for disease gene expression data for Malignant Tumor of Penis.

Pathways for Malignant Tumor of Penis

GO Terms for Malignant Tumor of Penis

Sources for Malignant Tumor of Penis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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