MCID: MMM007
MIFTS: 34

Mammary Analogue Secretory Carcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Mammary Analogue Secretory Carcinoma

MalaCards integrated aliases for Mammary Analogue Secretory Carcinoma:

Name: Mammary Analogue Secretory Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080808

Summaries for Mammary Analogue Secretory Carcinoma

Disease Ontology : 12 A salivary gland carcinoma that has material basis in a chromosomal translocation that results in an ETV6-NTRK3 fusion gene.

MalaCards based summary : Mammary Analogue Secretory Carcinoma is related to acinar cell carcinoma and pleomorphic adenoma. An important gene associated with Mammary Analogue Secretory Carcinoma is ETV6 (ETS Variant Transcription Factor 6), and among its related pathways/superpathways are ERK Signaling and Toll-like Receptor Signaling Pathway. Affiliated tissues include salivary gland, breast and thyroid, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 74 Mammary analogue secretory carcinoma (MASC) (also termed MASCSG; the "SG" subscript indicates salivary... more...

Related Diseases for Mammary Analogue Secretory Carcinoma

Diseases related to Mammary Analogue Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 acinar cell carcinoma 31.3 TP53 NTRK3 ETV6 CTNNB1
2 pleomorphic adenoma 30.7 TP53 MUC1 CTNNB1
3 adenoma 30.4 TP53 MUC1 CTNNB1 CCND1
4 mucinous adenocarcinoma 30.4 TP53 MUC1 EGFR
5 salivary gland carcinoma 30.4 TP53 NTRK3 ETV6 EGFR
6 breast secretory carcinoma 30.3 STAT5A NTRK3 MUC4 ETV6
7 rhabdoid cancer 30.2 TP53 MUC1 CCND1
8 mucoepidermoid carcinoma 30.2 TP53 MUC4 MUC1 EGFR CTNNB1 CCND1
9 polymorphous low-grade adenocarcinoma 30.1 NTRK3 MUC1 CTNNB1 CCND1
10 lymphangioma 30.0 TP53 EGFR CTNNB1 CCND1
11 atypical teratoid rhabdoid tumor 29.9 TP53 MUC1 CTNNB1 CCND1
12 adenocarcinoma 29.7 TP53 NTRK3 MUC4 MUC1 EGFR CTNNB1
13 in situ carcinoma 29.7 TP53 MUC1 EGFR CTNNB1 CCND1
14 adenoid cystic carcinoma 29.5 TP53 SOX10 NTRK3 MUC1 EGFR CTNNB1
15 cystadenocarcinoma 10.6
16 rare tumor 10.4
17 cellular congenital mesoblastic nephroma 10.4 NTRK3 ETV6
18 adult fibrosarcoma 10.4 NTRK3 ETV6
19 breast adenoid cystic carcinoma 10.4 NTRK3 ETV6
20 cerebellar angioblastoma 10.3 NTRK3 ETV6
21 microcystic stromal tumor 10.3 CTNNB1 CCND1
22 kidney cortex disease 10.3 NTRK3 ETV6
23 malignant peritoneal mesothelioma 10.3 MUC1 EGFR
24 breast scirrhous carcinoma 10.3 MUC1 EGFR
25 polykaryocytosis inducer 10.3
26 oncocytoma 10.3
27 facial paralysis 10.3
28 appendix adenocarcinoma 10.3
29 myoepithelial carcinoma 10.3
30 epithelial-myoepithelial carcinoma 10.3
31 lymphoepithelioma-like carcinoma 10.3
32 posttransplant acute limbic encephalitis 10.3
33 rapidly involuting congenital hemangioma 10.3
34 ethmoid sinus adenocarcinoma 10.2 EGFR CCND1
35 chronic ethmoiditis 10.2 MUC4 MUC1
36 esophageal leukoplakia 10.2 TP53 CCND1
37 bile duct mucoepidermoid carcinoma 10.2 MUC4 MUC1
38 lung sarcomatoid carcinoma 10.2 MUC4 MUC1
39 pediatric fibrosarcoma 10.2 NTRK3 ETV6
40 pleomorphic adenoma carcinoma 10.2 TP53 NTRK3
41 filamentary keratitis 10.2 MUC4 MUC1
42 vulvar intraepithelial neoplasia 10.2 TP53 CTNNB1
43 mucinous tubular and spindle renal cell carcinoma 10.2 MUC4 MUC1
44 biliary tract cancer 10.2 MUC4 EGFR
45 limbal stem cell deficiency 10.2 MUC4 MUC1
46 nephroma 10.2 NTRK3 MUC1 ETV6
47 ischemic fasciitis 10.2 MUC1 CCND1
48 esophageal basaloid squamous cell carcinoma 10.2 TP53 EGFR
49 spindle cell sarcoma 10.2 NTRK3 MUC1 ETV6
50 frontal lobe neoplasm 10.2 TP53 EGFR

Graphical network of the top 20 diseases related to Mammary Analogue Secretory Carcinoma:



Diseases related to Mammary Analogue Secretory Carcinoma

Symptoms & Phenotypes for Mammary Analogue Secretory Carcinoma

MGI Mouse Phenotypes related to Mammary Analogue Secretory Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.01 CCND1 CTNNB1 EGFR ETV6 PLIN2 SOX10
2 digestive/alimentary MP:0005381 9.98 CA6 CCND1 CTNNB1 EGFR ETV6 SOX10
3 integument MP:0010771 9.97 CCND1 CTNNB1 EGFR ETV6 PLIN2 SOX10
4 liver/biliary system MP:0005370 9.8 CTNNB1 EGFR ETV6 PLIN2 STAT5A TP53
5 neoplasm MP:0002006 9.73 CCND1 CTNNB1 EGFR ETV6 SOX10 TP53
6 no phenotypic analysis MP:0003012 9.63 CTNNB1 EGFR ETV6 NTRK3 SOX10 TP53
7 normal MP:0002873 9.56 CCND1 CTNNB1 EGFR ETV6 NTRK3 SOX10
8 respiratory system MP:0005388 9.1 CCND1 CTNNB1 EGFR NTRK3 SOX10 TP53

Drugs & Therapeutics for Mammary Analogue Secretory Carcinoma

Search Clinical Trials , NIH Clinical Center for Mammary Analogue Secretory Carcinoma

Genetic Tests for Mammary Analogue Secretory Carcinoma

Anatomical Context for Mammary Analogue Secretory Carcinoma

MalaCards organs/tissues related to Mammary Analogue Secretory Carcinoma:

40
Salivary Gland, Breast, Thyroid, Skin, Lymph Node, Tongue

Publications for Mammary Analogue Secretory Carcinoma

Articles related to Mammary Analogue Secretory Carcinoma:

(show top 50) (show all 131)
# Title Authors PMID Year
1
Secretory Carcinoma (Mammary Analogue Secretory Carcinoma) of the Vulva With ETV6 Gene Rearrangement: A Brief Report With Follow-up. 61
33290355 2021
2
Primary Mammary-Analogue Secretory Carcinoma of the Lung: A Rare Entity With an Unusual Location. 61
32279588 2020
3
Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland. 61
31502214 2020
4
Atypical Presentation of Mammary Analogue Secretory Carcinoma of the Lip. 61
32951456 2020
5
MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics. 61
32931030 2020
6
MR imaging findings of a rare pediatric parotid tumor: Mammary analogue secretory carcinoma. 61
32642018 2020
7
A case of mammary analogue secretory carcinoma of the parotid gland: A case report. 61
32664055 2020
8
Perithyroidal Salivary Gland Acinic Cell Carcinoma: Morphological and Molecular Attributes of a Unique Lesion. 61
32519264 2020
9
(Mammary Analogue) Secretory Carcinoma of the Nasal Cavity: Report of a Rare Case with p63 and DOG1 Expression and Uncommon Exon 4-Exon 14 ETV6-NTRK3 Fusion Diagnosed with Next Generation Sequencing. 61
31273600 2020
10
Mammary analogue secretory carcinoma: A case report. 61
32395809 2020
11
Mammary analogue secretory carcinoma: An Indian experience of a novel entity. 61
32108646 2020
12
Outcomes of treatment of mammary analogue secretory carcinoma of the parotid gland. 61
31859109 2020
13
[Secretory carcinoma of the salivary gland (mammary analogue secretory carcinoma) in children]. 61
32307438 2020
14
Synchronous Parotid (Mammary Analog) Secretory Carcinoma and Acinic Cell Carcinoma: Report of a Case. 61
29876739 2019
15
Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland. 61
31440815 2019
16
Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck. 61
31464708 2019
17
Mammary analogue secretory carcinoma presenting as a cystic parotid mass. 61
31338135 2019
18
Immunohistochemistry with a pan-TRK antibody distinguishes secretory carcinoma of the salivary gland from acinic cell carcinoma. 61
30801752 2019
19
Locally advanced mammary analogue secretory carcinoma of the parotid gland. 61
30777712 2019
20
Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma. 61
30779892 2019
21
Diagnostic utility of fluorescence in situ hybridization testing on cytology cell blocks for the definitive classification of salivary gland neoplasms. 61
31097292 2019
22
Mammary analogue secretory carcinoma of salivary gland diagnosed on submandibular gland cytology: A case report and review of the literature. 61
30506593 2019
23
Neurotrophic tropomyosin or t´╗┐yrosine receptor kinase (NTRK) genes. 61
30636697 2019
24
How I treat NTRK gene fusion-positive cancers. 61
31803506 2019
25
Mammary analogue secretory carcinoma of the minor salivary gland: report of two cases. 61
31933835 2019
26
The significance of the morphological and immunological characteristics in the diagnosis of parotid mammary analogue secretory carcinoma: five case reports and a review of the literature. 61
31934046 2019
27
A Challenging Case of Mammary Analogue Secretory Carcinoma: Case Study with Ultrastructural and Cytogenetic Correlation. 61
31929931 2019
28
Mammary Analogue Secretory Carcinoma of the Palate: Case Report and Review of the Literature. 61
30937197 2019
29
A case report of parotid mammary analogue secretory carcinoma and reviews. 61
30716709 2019
30
Mammary Analogue Secretory Carcinoma Arising in the Parotid Gland of Child. 61
30656126 2018
31
Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions: A Report of 17 cases. 61
30045065 2018
32
Mammary analogue secretory carcinoma of salivary glands: Report of clinical case. 61
29033125 2018
33
Mammary Analogue Secretory Carcinoma of the Thyroid Mimicking Locally Advanced Papillary Thyroid Carcinoma: A Rare Case Report. 61
29228842 2018
34
Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma. 61
30186957 2018
35
Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion: Expanding the Molecular Spectrum of a Recently Described Entity. 61
29683815 2018
36
MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report. 61
29493279 2018
37
Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed (mammary analogue) secretory carcinoma of salivary glands. 61
29909898 2018
38
The screening and electron microscopy observation of mammary analogue secretory carcinoma in Chinese. 61
29752049 2018
39
Secretory carcinoma of the parotid with adenoid cystic carcinoma cytological pattern: A cytological-pathological correlation with literature review. 61
29566949 2018
40
Primary mammary analogue secretory carcinoma of the lung: a case report. 61
29104113 2018
41
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. 61
29205457 2018
42
Esophageal Mammary Analogue Secretory Carcinoma. 61
28189694 2018
43
Additional diagnostic features of mammary analogue secretory carcinoma on cytology. 61
28929545 2018
44
Mammary Analogue Secretory Carcinoma of Minor Salivary Glands: A Rare Case Series and Review of the Literature. 61
29531003 2018
45
Special types of thyroid carcinoma. 61
29239042 2018
46
Ultrastructural Characterization of Mammary Analogue Secretory Carcinoma of the Salivary Glands: A Distinct Entity from Acinic Cell Carcinoma? 61
28194567 2017
47
Pure intraductal carcinoma of the parotid gland: Cytologic findings on FNA sample. Report of one case. 61
28646544 2017
48
Secretory carcinoma - impact of translocation and gene fusions on salivary gland tumor. 61
29142456 2017
49
Mammary analogue secretory carcinoma of salivary glands: diagnostic pitfall with distinct immunohistochemical profile and molecular features. 61
29081930 2017
50
A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma. 61
28802370 2017

Variations for Mammary Analogue Secretory Carcinoma

Expression for Mammary Analogue Secretory Carcinoma

Search GEO for disease gene expression data for Mammary Analogue Secretory Carcinoma.

Pathways for Mammary Analogue Secretory Carcinoma

Pathways related to Mammary Analogue Secretory Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 TP53 STAT5A SOX10 NTRK3 MUC1 EGFR
2
Show member pathways
12.89 TP53 STAT5A EGFR CTNNB1 CCND1
3
Show member pathways
12.62 TP53 STAT5A EGFR CTNNB1 CCND1
4
Show member pathways
12.61 TP53 EGFR CTNNB1 CCND1
5 12.56 TP53 STAT5A EGFR CTNNB1 CCND1
6
Show member pathways
12.53 TP53 STAT5A EGFR CCND1
7
Show member pathways
12.45 TP53 STAT5A EGFR CCND1
8
Show member pathways
12.45 STAT5A EGFR CTNNB1 CCND1
9
Show member pathways
12.42 TP53 STAT5A EGFR CTNNB1
10
Show member pathways
12.31 TP53 MUC1 EGFR CTNNB1
11
Show member pathways
12.26 TP53 NTRK3 EGFR CTNNB1
12
Show member pathways
12.06 TP53 NTRK3 EGFR CCND1
13 12.03 TP53 CTNNB1 CCND1
14
Show member pathways
12.03 TP53 EGFR CTNNB1 CCND1
15 11.98 STAT5A NTRK3 CTNNB1
16 11.98 TP53 EGFR CTNNB1 CCND1
17 11.93 STAT5A PLIN2 CTNNB1
18 11.88 TP53 CTNNB1 CCND1
19 11.87 TP53 EGFR CCND1
20 11.85 TP53 CTNNB1 CCND1
21 11.83 TP53 MUC1 CCND1
22 11.78 TP53 EGFR CTNNB1 CCND1
23 11.69 EGFR CTNNB1 CCND1
24 11.64 TP53 EGFR CTNNB1 CCND1
25 11.56 TP53 EGFR CCND1
26 11.53 TP53 NTRK3 EGFR
27 11.5 STAT5A EGFR CTNNB1
28 11.21 TP53 EGFR CCND1
29 10.97 TP53 EGFR CTNNB1 CCND1
30 10.92 STAT5A CCND1
31 10.65 TP53 EGFR CTNNB1

GO Terms for Mammary Analogue Secretory Carcinoma

Biological processes related to Mammary Analogue Secretory Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 TP53 SOX10 ETV6 CTNNB1 CCND1
2 response to drug GO:0042493 9.67 TP53 PLIN2 CTNNB1 CCND1
3 response to organic cyclic compound GO:0014070 9.65 PLIN2 EGFR CCND1
4 cytokine-mediated signaling pathway GO:0019221 9.62 TP53 STAT5A MUC1 CCND1
5 response to estradiol GO:0032355 9.61 EGFR CTNNB1 CCND1
6 positive regulation of neuroblast proliferation GO:0002052 9.54 SOX10 CTNNB1
7 response to X-ray GO:0010165 9.52 TP53 CCND1
8 response to corticosterone GO:0051412 9.49 NTRK3 CCND1
9 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.46 TP53 MUC1
10 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.4 TP53 EGFR
11 mitotic G1 DNA damage checkpoint GO:0031571 9.26 TP53 CCND1
12 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.16 TP53 MUC1
13 cellular response to drug GO:0035690 9.13 TP53 SOX10 EGFR
14 response to UV-A GO:0070141 8.62 EGFR CCND1

Molecular functions related to Mammary Analogue Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.67 TP53 SOX10 EGFR CTNNB1
2 enzyme binding GO:0019899 9.62 TP53 EGFR CTNNB1 CCND1
3 transcription factor binding GO:0008134 9.56 TP53 SOX10 CTNNB1 CCND1
4 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216 9.16 TP53 SOX10
5 protein phosphatase binding GO:0019903 9.13 TP53 EGFR CTNNB1
6 p53 binding GO:0002039 8.8 TP53 NTRK3 MUC1

Sources for Mammary Analogue Secretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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