MCID: MMM001
MIFTS: 53

Mammary Paget's Disease

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Mammary Paget's Disease

MalaCards integrated aliases for Mammary Paget's Disease:

Name: Mammary Paget's Disease 12 20 15
Paget's Disease 12 15 70
Paget's Disease of the Breast 12 73
Paget's Disease of the Nipple 20 58
Paget Disease of the Breast 20 58
Paget's Disease, Mammary 20 70
Mammary Paget Disease 12 58
Paget Disease of the Nipple 58
Pagets Disease Mammary 54
Paget Cell Neoplasm 12
Osteitis Deformans 70

Characteristics:

Orphanet epidemiological data:

58
paget disease of the nipple
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3443
NCIt 50 C7073
MESH via Orphanet 45 D010144
ICD10 via Orphanet 33 C50.0
UMLS via Orphanet 71 C0030185 C1704323
Orphanet 58 ORPHA180275
UMLS 70 C0029401 C0030185 C1368019

Summaries for Mammary Paget's Disease

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 180275 Definition Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.

MalaCards based summary : Mammary Paget's Disease, also known as paget's disease, is related to scrotum paget's disease and paget disease, extramammary, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Mammary Paget's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Gastric cancer and Relaxin signaling pathway. The drugs Alendronate and Pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and skin, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Disease Ontology : 12 A breast adenocarcinoma that has material basis in epidermal Paget cells, which are malignant glandular epithelial cells with abundant and clear cytoplasm, usually containing mucin, and pleomorphic and hyperchromatic nucleus.

Wikipedia : 73 Paget's disease of the breast is a type of cancer that outwardly may have the appearance of eczema, with... more...

Related Diseases for Mammary Paget's Disease

Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 832)
# Related Disease Score Top Affiliating Genes
1 scrotum paget's disease 32.6 MUC1 KRT7
2 paget disease, extramammary 32.1 MUC1 KRT7 KRT20 ERBB2 AR
3 paget disease of bone 5, juvenile-onset 32.1 TNFSF11 CALCA
4 paget's disease of bone 32.1 VCP TNFSF11 SQSTM1 PTH CALCA BGLAP
5 bone disease 31.2 TNFSF11 PTH ESR1 CALCA BGLAP ACP5
6 rectum adenocarcinoma 31.0 KRT7 KRT20 ERBB2 EGFR
7 adenocarcinoma in situ 30.8 KRT7 KRT20 EGFR
8 appendix adenocarcinoma 30.8 KRT7 KRT20
9 fibrous dysplasia 30.8 TNFSF11 CALCA BGLAP
10 sebaceous adenocarcinoma 30.8 KRT14 ERBB2 AR
11 spastic paraplegia-paget disease of bone syndrome 30.8 VCP SQSTM1
12 osteomalacia 30.8 PTH CALCA BGLAP
13 transitional cell carcinoma 30.8 KRT8 KRT7 KRT20 ERBB2 EGFR
14 vulva cancer 30.7 KRT7 ERBB2 EGFR
15 breast squamous cell carcinoma 30.7 ESR1 ERBB2
16 in situ carcinoma 30.7 PGR MUC1 KRT8 KRT14 ESR1 ERBB2
17 benign giant cell tumor 30.7 TNFSF11 MUC1 CALCA BGLAP
18 basal cell carcinoma 30.7 KRT8 KRT7 KRT20 KRT14 EGFR
19 anal canal adenocarcinoma 30.7 KRT7 KRT20
20 fibroepithelial basal cell carcinoma 30.6 KRT20 KRT14
21 vulval paget's disease 30.6 KRT7 ERBB2
22 intracranial meningioma 30.6 PGR ESR1
23 hyperparathyroidism 30.6 TNFSF11 PTH CALCA BGLAP ACP5
24 adenoma 30.6 PTH MUC1 KRT7 KRT20
25 primary hyperparathyroidism 30.6 TNFSF11 PTH CALCA BGLAP
26 vulvar disease 30.5 KRT7 ERBB2 EGFR
27 osteomyelitis 30.5 TNFSF11 CALCA ACP5
28 eccrine papillary adenocarcinoma 30.5 PGR KRT8 KRT7 KRT14
29 bone resorption disease 30.5 TNFSF11 PTH FDPS ESR1 CALCA BGLAP
30 ductal carcinoma in situ 30.5 PGR MUC1 KRT8 KRT14 ESR1 ERBB2
31 apocrine adenocarcinoma 30.5 PGR MUC1 KRT7 ESR1 ERBB2 EGFR
32 angiosarcoma 30.4 MUC1 KRT8 KRT7
33 secondary hyperparathyroidism 30.4 PTH CALCA BGLAP ACP5
34 gynecomastia 30.4 PGR ESR1 ERBB2 AR
35 colorectal adenocarcinoma 30.4 MUC1 KRT7 KRT20 ERBB2 EGFR
36 sweat gland cancer 30.4 PGR KRT8 KRT7 KRT20 ESR1 ERBB2
37 female breast cancer 30.4 PGR ESR1 ERBB2 AR
38 bilateral breast cancer 30.3 PGR ESR1 ERBB2
39 cervical adenocarcinoma 30.3 KRT7 KRT20 ESR1 ERBB2 EGFR
40 skin carcinoma 30.3 PGR KRT8 KRT7 KRT20 KRT14 ESR1
41 spondyloarthropathy 1 30.3 TNFSF11 PTH BGLAP
42 villous adenoma 30.2 MUC1 KRT8 KRT7 KRT20
43 adenocarcinoma 30.2 MUC1 KRT7 KRT20 ERBB2 EGFR
44 merkel cell carcinoma 30.2 MUC1 KRT8 KRT7 KRT20
45 bone giant cell tumor 30.2 TNFSF11 PTH CALCA ACP5
46 mucinous adenocarcinoma 30.2 PGR MUC1 KRT7 KRT20 ESR1 ERBB2
47 breast papillary carcinoma 30.2 PGR ESR1 ERBB2
48 comedo carcinoma 30.2 PGR ESR1 ERBB2
49 bladder adenocarcinoma 30.2 KRT7 KRT20 ERBB2
50 suppression of tumorigenicity 12 30.2 KRT8 ERBB2 EGFR AR

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to Mammary Paget's Disease

Symptoms & Phenotypes for Mammary Paget's Disease

UMLS symptoms related to Mammary Paget's Disease:


back pain; sciatica; muscle cramp

MGI Mouse Phenotypes related to Mammary Paget's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 AR BGLAP CFTR EGFR ESR1 KRT14
2 endocrine/exocrine gland MP:0005379 10.17 AR BGLAP CFTR EGFR ERBB2 ESR1
3 immune system MP:0005387 10.15 AR BGLAP CFTR EGFR ESR1 KRT14
4 integument MP:0010771 10.02 AR EGFR ERBB2 ESR1 KRT14 LALBA
5 limbs/digits/tail MP:0005371 9.86 AR EGFR ERBB2 ESR1 PGR PTH
6 neoplasm MP:0002006 9.7 AR EGFR ERBB2 ESR1 KRT14 PGR
7 reproductive system MP:0005389 9.65 AR BGLAP CFTR EGFR ERBB2 ESR1
8 skeleton MP:0005390 9.32 AR BGLAP EGFR ERBB2 ESR1 PGR

Drugs & Therapeutics for Mammary Paget's Disease

Drugs for Mammary Paget's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
2
Pamidronate Approved Phase 4 40391-99-9 4674
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
4 Diphosphonates Phase 4
5 Nutrients Phase 4
6 Micronutrients Phase 4
7 Trace Elements Phase 4
8 Vitamins Phase 4
9 Calciferol Phase 4
10 Calcium, Dietary Phase 4
11 Hormones Phase 4
12 Pharmaceutical Solutions Phase 4
13
Calcium Nutraceutical Phase 4 7440-70-2 271
14
Etidronic acid Approved Phase 3 7414-83-7, 2809-21-4 3305
15
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
16
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
17
Acetaminophen Approved Phase 3 103-90-2 1983
18
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
19
Petrolatum Approved, Investigational Phase 3 8009-03-8
20 Immunologic Factors Phase 3
21 calcium channel blockers Phase 3
22 Anti-Arrhythmia Agents Phase 3
23 Sodium Channel Blockers Phase 3
24 Analgesics, Non-Narcotic Phase 3
25 Anesthetics Phase 3
26 Adjuvants, Immunologic Phase 3
27 Analgesics Phase 3
28 Dermatologic Agents Phase 3
29 Diuretics, Potassium Sparing Phase 3
30 Anesthetics, Local Phase 3
31 interferons Phase 3
32 Emollients Phase 3
33 Antipyretics Phase 3
34 Omega 3 Fatty Acid Phase 2
35
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
36
Metronidazole Approved Phase 1 443-48-1 4173
37
Molgramostim Investigational Phase 1 99283-10-0
38 Anti-Infective Agents Phase 1
39 Vaccines Phase 1
40 Anti-Bacterial Agents Phase 1
41 Antiparasitic Agents Phase 1
42 Antiprotozoal Agents Phase 1
43
Zoledronic Acid Approved 118072-93-8 68740
44 Fluorides
45 Methyl 5-aminolevulinate
46 Photosensitizing Agents

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
2 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
3 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
4 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
5 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
6 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
7 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
8 Topical 5% Imiquimod Cream for Vulvar Paget's Disease: Clinical Efficacy, Safety and Immunological Response Completed NCT02385188 Phase 3 Imiquimod;paracetamol;lidocaine in Vaseline ointment
9 A Multicenter Phase II Study of Docosahexaenoic Acid (DHA) in Patients With a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease Unknown status NCT01849250 Phase 2 Docosahexaenoic Acid
10 A Randomized, Open-label Therapeutic Trial Evaluating the Efficacy and Safety of Neridronate (Nerixia®) in the Treatment of Osteoporosis in Patients With Thalassemia Major and Severe Thalassemia Intermedia. Completed NCT01140321 Phase 2 Neridronate
11 A Phase II Evaluation of Trastuzumab In Patients With HER2 Positive Persistent Or Recurrent Vulvar Paget's Disease Withdrawn NCT01427244 Phase 2 trastuzumab
12 Phase I Study of a Recombinant Fowl Pox Vaccine rF-CEA (6D)/TRICOM Alone or With GM-CSF in Patients With Advanced CEA Expressing Adenocarinomas Completed NCT00028496 Phase 1
13 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
14 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
15 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance - Completed NCT02106455 Sodium risedronate
16 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
17 Analyses of the Outcome of a Treatment of Vulvar Paget Disease Completed NCT03900975
18 A Pilot Study of Topical Imiquimod Therapy for the Treatment of Recurrent Extramammary Paget's Disease Completed NCT00504023 imiquimod
19 An Interventional, Phase II, Non Randomized, Mono-centric Study on the Clinical Efficacy and Safety of the Medical Device PAGETEX® as a Photodynamic Therapy Device in the Treatment of Extra-Mammary Paget's Disease of the Vulva (EMPV) Recruiting NCT03713203
20 Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone Recruiting NCT02802384
21 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430
22 Prospective Registry of Gynecologic Patients With Extramammary Paget's Disease Recruiting NCT03564483
23 Zoledronate In the Prevention of Paget's Disease: Long Term Extension Recruiting NCT03859895
24 Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone Terminated NCT00615628

Search NIH Clinical Center for Mammary Paget's Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Calcitonin
salmon calcitonin

Genetic Tests for Mammary Paget's Disease

Anatomical Context for Mammary Paget's Disease

MalaCards organs/tissues related to Mammary Paget's Disease:

40
Bone, Breast, Skin, Spinal Cord, Lymph Node, Prostate, Bone Marrow

Publications for Mammary Paget's Disease

Articles related to Mammary Paget's Disease:

(show top 50) (show all 6878)
# Title Authors PMID Year
1
Apocrine gland carcinoma of the mammary skin concomitant with pagetoid phenomenon. 54 61
20507405 2010
2
[Pigmented Paget's disease of the breast]. 61 54
18374854 2008
3
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. 54 61
17040462 2006
4
Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. 54 61
15920545 2005
5
Mammary and extramammary Paget's disease. 54 61
11064666 2000
6
Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. 61 54
9989849 1999
7
c-erbB-2 oncoprotein expression in mammary and extramammary Paget's disease: an immunohistochemical study. 54 61
2173676 1990
8
The role of autophagy in bone homeostasis. 61
33452680 2021
9
Fracture of tibial tuberosity in an adult with Paget's disease of the bone - An interesting case and review of literature. 61
33681443 2021
10
Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease. 61
33107091 2021
11
Magnetic resonance imaging in the evaluation of pathologic nipple discharge: indications and imaging findings. 61
33544650 2021
12
Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation. 61
33725152 2021
13
CT Assessment of Otic Capsule Bone Density in Paget's Disease of the Temporal Bone and Its Relationship With Hearing Loss. 61
33710141 2021
14
A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws. 61
32730731 2021
15
The nipple-areolar complex: comprehensive imaging review. 61
33077158 2021
16
Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology. 61
33768371 2021
17
New advances in Amyotrophic Lateral Sclerosis genetics: Towards gene therapy opportunities for familial and young cases. 61
33810837 2021
18
Insertion mutation in Tnfrsf11a causes a Paget's disease-like phenotype in heterozygous mice and osteopetrosis in homozygous mice. 61
33724536 2021
19
The French multicentre elevated bone mass study: prevalence and causes. 61
33655400 2021
20
Novel operative technique of advancement urethral meatoplasty utilizing buccal mucosa for Vulvar Paget's disease with urethral invasion: two case reports. 61
33773597 2021
21
Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy. 61
33719120 2021
22
Initial topical monotherapy may increase the risk of recurrence in patients with extramammary Paget's disease. 61
33666282 2021
23
Clinical and radiological outcomes of total hip arthroplasty in patients affected by Paget's disease: a combined registry and single-institution retrospective observational study. 61
33733386 2021
24
Extramammary Paget's disease of the hard palate: A case report and review of the literature. 61
33406310 2021
25
Pigmented Paget's Disease. 61
33657888 2021
26
Surgical margin status and recurrence pattern in invasive vulvar Paget's disease: A Japanese Gynecologic Oncology Group study. 61
33384164 2021
27
The Skinner Burial of Ontario, Canada, and the Question of Paget's Disease in the Americas. 61
33197696 2021
28
Extramammary Paget's disease: in vivo dynamic optical coherence tomography imaging. 61
32978824 2021
29
Not All Cases of Mammary Paget's Disease are Cytokeratin-7 Positive: A Challenging Diagnosis! 61
33750236 2021
30
Complete but transient clinical remission of vulvar Paget's disease with paclitaxel and trastuzumab. 61
33422298 2021
31
Recalcitrant extramammary Paget's disease treated successfully with high-dose-rate brachytherapy: A case series and review of the literature. 61
33406300 2021
32
Prevalence of extramammary Paget's disease in urban China: a population-based study. 61
33731175 2021
33
Invasive and non-invasive extramammary perianal Paget's disease: Understanding of carcinogenesis determines individualized treatment. 61
33685631 2021
34
Incidence of Paget's Disease of Bone in the UK: Evidence of a Continuing Decline. 61
33742666 2021
35
Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors. 61
33599011 2021
36
Local Recurrence Rates of Skin Tumors After Resection With Complete Circumferential Peripheral and Deep Margin Assessment-Identification of High-Risk Entities. 61
33565775 2021
37
Pulmonary wedge aspiration cytology for the rapid diagnosis of pulmonary tumor thrombotic microangiopathy: A case report. 61
33590672 2021
38
Severe Graves' disease-associated orbitopathy: A rare case of frontal bone hemangioma. 61
33598245 2021
39
Zoledronic Acid after Treatment with Denosumab is Associated with Bone Loss within 1 Year. 61
33730783 2021
40
[Paget's disease of bone-a current review of clinical aspects, diagnostics and treatment]. 61
33005994 2021
41
Conservative Management of Medication-Related Osteonecrosis of the Jaws (MRONJ): A Retrospective Cohort Study. 61
33671429 2021
42
Bisphosphonates for the treatment of fibrous dysplasia of bone. 61
33276154 2021
43
Existence of Staphylococcus aureus correlates with the progression of extramammary Paget's disease: potential involvement of interleukin-17 and M2-like macrophage polarization. 61
33586656 2021
44
Clodronate. 61
33127577 2021
45
Teriparatide Did Not Increase Adult Osteosarcoma Incidence in a 15-Year US Postmarketing Surveillance Study. 61
32990990 2021
46
Mammary Paget's disease and radiotherapy: a systematic literature review. 61
33660791 2021
47
A strengthening the reporting of observational studies in epidemiology (STROBE): Are HE4 and CA 125 suitable to detect a Paget disease of the vulva? 61
33592901 2021
48
Effects of Bisphosphonate Treatment on Circulating Lipid and Glucose Levels in Patients with Metabolic Bone Disorders. 61
33559705 2021
49
Pre-Paget cells express a Paget cell marker before losing a keratinocyte marker. 61
33614379 2021
50
Paget's Disease in Primary Total Hip Arthroplasty Is Associated With Greater In-Hospital Lengths of Stay, Costs, and Complications. 61
32988682 2021

Variations for Mammary Paget's Disease

Expression for Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for Mammary Paget's Disease

GO Terms for Mammary Paget's Disease

Cellular components related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 VCP SQSTM1 PGR KRT8 KRT7 KRT20
2 cytoplasm GO:0005737 9.55 VCP TNFSF11 SQSTM1 PGR MUC1 KRT8
3 intermediate filament GO:0005882 9.46 KRT8 KRT7 KRT20 KRT14

Biological processes related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 TNFSF11 SQSTM1 PTH PGR ESR1 EGFR
2 keratinization GO:0031424 9.86 KRT8 KRT7 KRT20 KRT14
3 positive regulation of protein kinase B signaling GO:0051897 9.8 TNFSF11 ESR1 ERBB2 EGFR
4 cellular response to growth factor stimulus GO:0071363 9.74 ERBB2 EGFR BGLAP
5 cornification GO:0070268 9.71 KRT8 KRT7 KRT20 KRT14
6 positive regulation of MAP kinase activity GO:0043406 9.69 TNFSF11 ERBB2 EGFR
7 ossification GO:0001503 9.67 TNFSF11 EGFR BGLAP ACP5
8 positive regulation of phosphorylation GO:0042327 9.61 TNFSF11 EGFR AR
9 cell-cell signaling GO:0007267 9.55 PTH PGR LALBA CALCA AR
10 paracrine signaling GO:0038001 9.54 TNFSF11 PGR
11 magnesium ion homeostasis GO:0010960 9.52 PTH EGFR
12 negative regulation of ERBB signaling pathway GO:1901185 9.48 ERBB2 EGFR
13 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.46 PGR AR
14 bone resorption GO:0045453 9.43 TNFSF11 PTH ACP5
15 response to hydroxyisoflavone GO:0033594 9.32 EGFR BGLAP
16 mammary gland alveolus development GO:0060749 9.13 TNFSF11 ESR1 AR
17 intracellular steroid hormone receptor signaling pathway GO:0030518 8.8 PGR ESR1 AR

Molecular functions related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 10.03 VCP TNFSF11 SQSTM1 PGR ESR1 ERBB2
2 protein-containing complex binding GO:0044877 9.8 VCP SQSTM1 KRT8 EGFR CALCA
3 signaling receptor binding GO:0005102 9.77 VCP PGR EGFR CALCA AR
4 protein phosphatase binding GO:0019903 9.65 VCP ERBB2 EGFR
5 nitric-oxide synthase regulator activity GO:0030235 9.46 ESR1 EGFR
6 nuclear receptor activity GO:0004879 9.43 PGR ESR1 AR
7 steroid binding GO:0005496 9.33 PGR ESR1 AR
8 RNA polymerase II transcription coactivator binding GO:0001225 9.32 PGR AR
9 ATPase binding GO:0051117 9.26 PGR ESR1 EGFR AR
10 enzyme binding GO:0019899 9.1 SQSTM1 PGR ESR1 EGFR CFTR AR

Sources for Mammary Paget's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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