MCID: MMM001
MIFTS: 53

Mammary Paget's Disease

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Mammary Paget's Disease

MalaCards integrated aliases for Mammary Paget's Disease:

Name: Mammary Paget's Disease 12 52 15
Paget's Disease 12 15 71
Paget's Disease of the Breast 12 74
Paget's Disease of the Nipple 52 58
Paget Disease of the Breast 52 58
Paget's Disease, Mammary 52 71
Mammary Paget Disease 12 58
Paget Disease of the Nipple 58
Pagets Disease Mammary 54
Paget Cell Neoplasm 12
Osteitis Deformans 71

Characteristics:

Orphanet epidemiological data:

58
paget disease of the nipple
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3443
NCIt 49 C7073
MESH via Orphanet 44 D010144
ICD10 via Orphanet 33 C50.0
UMLS via Orphanet 72 C0030185 C1704323
Orphanet 58 ORPHA180275
UMLS 71 C0029401 C0030185 C1368019

Summaries for Mammary Paget's Disease

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 180275 Definition Paget disease of the nipple describes a rare presentation of breast cancer , seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses. Visit the Orphanet disease page for more resources.

MalaCards based summary : Mammary Paget's Disease, also known as paget's disease, is related to scrotum paget's disease and paget's disease of bone, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Mammary Paget's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Gastric cancer and Relaxin signaling pathway. The drugs Tocopherol and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and skin, and related phenotypes are hematopoietic system and cellular

Disease Ontology : 12 A breast adenocarcinoma that has material basis in epidermal Paget cells, which are malignant glandular epithelial cells with abundant and clear cytoplasm, usually containing mucin, and pleomorphic and hyperchromatic nucleus.

Wikipedia : 74 Paget's disease of the breast is a type of cancer that outwardly may have the appearance of eczema, with... more...

Related Diseases for Mammary Paget's Disease

Diseases related to Mammary Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 823)
# Related Disease Score Top Affiliating Genes
1 scrotum paget's disease 34.6 MUC1 KRT7
2 paget's disease of bone 34.0 VCP TNFSF11 TNFRSF11B SQSTM1 CALCA BGLAP
3 paget disease of bone 5, juvenile-onset 32.9 TNFSF11 TNFRSF11B CALCA
4 paget disease, extramammary 32.8 MUC1 KRT7 KRT20 ERBB2
5 familial expansile osteolysis 32.7 TNFSF11 TNFRSF11B SQSTM1
6 bone disease 32.0 TNFSF11 TNFRSF11B FDPS ESR1 CALCA BGLAP
7 hyperparathyroidism 31.1 TNFSF11 TNFRSF11B CALCA BGLAP
8 adenocarcinoma in situ 31.0 KRT7 KRT20 EGFR
9 rectum adenocarcinoma 31.0 KRT7 KRT20 ERBB2 EGFR CD274
10 osteomalacia 30.9 TNFSF11 CALCA BGLAP
11 appendix adenocarcinoma 30.9 KRT7 KRT20
12 transitional cell carcinoma 30.9 KRT8 KRT7 KRT20 ERBB2 EGFR
13 secondary hyperparathyroidism 30.8 TNFRSF11B CALCA BGLAP
14 vulval paget's disease 30.8 KRT7 ERBB2
15 bone resorption disease 30.8 TNFSF11 TNFRSF11B FDPS ESR1 CALCA BGLAP
16 skin carcinoma 30.8 KRT8 KRT7 KRT20 EGFR CTLA4 CD274
17 fibroepithelial basal cell carcinoma 30.8 KRT20 KRT14
18 vulva cancer 30.8 KRT7 ERBB2 EGFR CD274
19 bone giant cell tumor 30.7 TNFSF11 TNFRSF11B CALCA
20 anus cancer 30.7 KRT7 EGFR CD274
21 in situ carcinoma 30.7 PGR MUC1 KRT8 KRT14 ESR1 ERBB2
22 primary hyperparathyroidism 30.7 TNFSF11 TNFRSF11B CALCA BGLAP
23 fibrous dysplasia 30.6 TNFSF11 TNFRSF11B CALCA BGLAP
24 hidrocystoma 30.6 KRT8 KRT7
25 eccrine papillary adenocarcinoma 30.6 PGR KRT8 KRT7 KRT14
26 basal cell carcinoma 30.6 KRT8 KRT7 KRT20 KRT14 EGFR CD274
27 syringoma 30.6 MUC1 KRT7 ESR1
28 chickenpox 30.6 PGR MUC1 CTLA4
29 exanthem 30.6 ERBB2 EGFR CTLA4 CD274
30 apocrine adenocarcinoma 30.6 PGR MUC1 KRT7 ESR1 ERBB2 EGFR
31 ductal carcinoma in situ 30.6 PGR MUC1 KRT8 KRT14 ESR1 ERBB2
32 gynecomastia 30.6 PGR ESR1 ERBB2
33 villous adenoma 30.6 MUC1 KRT8 KRT20
34 spiradenoma 30.6 MUC1 KRT7 KRT14
35 adenocarcinoma 30.6 MUC1 KRT7 KRT20 ERBB2 EGFR
36 sweat gland cancer 30.5 PGR KRT8 KRT7 KRT20 ESR1 ERBB2
37 angiosarcoma 30.5 MUC1 KRT8 KRT7
38 ankylosis 30.5 TNFSF11 TNFRSF11B BGLAP
39 female breast cancer 30.5 PGR ESR1 ERBB2 EGFR
40 bilateral breast cancer 30.5 PGR ESR1 ERBB2
41 benign giant cell tumor 30.5 TNFSF11 TNFRSF11B MUC1 CALCA BGLAP
42 endosteal hyperostosis, autosomal dominant 30.4 TNFSF11 TNFRSF11B SQSTM1
43 colorectal adenocarcinoma 30.4 MUC1 KRT7 KRT20 ERBB2 EGFR
44 meningioma, familial 30.4 PGR ESR1 ERBB2 EGFR
45 squamous cell carcinoma 30.4 MUC1 KRT7 KRT14 ERBB2 EGFR
46 cystadenoma 30.4 PGR MUC1 KRT7 KRT20
47 serous cystadenocarcinoma 30.3 PGR KRT7 ERBB2
48 breast papillary carcinoma 30.3 PGR ESR1 ERBB2
49 comedo carcinoma 30.3 PGR ESR1 ERBB2
50 bladder urothelial carcinoma 30.3 TNFRSF11B KRT7 KRT20 ERBB2 EGFR CD274

Graphical network of the top 20 diseases related to Mammary Paget's Disease:



Diseases related to Mammary Paget's Disease

Symptoms & Phenotypes for Mammary Paget's Disease

UMLS symptoms related to Mammary Paget's Disease:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Mammary Paget's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 BGLAP CD274 CFTR CTLA4 EGFR ESR1
2 cellular MP:0005384 10.2 BGLAP CD274 EGFR ERBB2 ESR1 KRT14
3 homeostasis/metabolism MP:0005376 10.18 BGLAP CD274 CFTR CTLA4 EGFR ERBB2
4 endocrine/exocrine gland MP:0005379 10.13 BGLAP CFTR CTLA4 EGFR ERBB2 ESR1
5 immune system MP:0005387 10.13 BGLAP CD274 CFTR CTLA4 EGFR ESR1
6 integument MP:0010771 10 CD274 CTLA4 EGFR ERBB2 ESR1 KRT14
7 mortality/aging MP:0010768 9.77 CD274 CFTR CTLA4 EGFR ERBB2 ESR1
8 limbs/digits/tail MP:0005371 9.7 EGFR ERBB2 ESR1 PGR TNFRSF11B TNFSF11
9 skeleton MP:0005390 9.36 BGLAP CD274 CTLA4 EGFR ERBB2 ESR1

Drugs & Therapeutics for Mammary Paget's Disease

Drugs for Mammary Paget's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
2
tannic acid Approved Phase 4 1401-55-4
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Zoledronic Acid Approved Phase 4 118072-93-8 68740
5
Pamidronate Approved Phase 4 40391-99-9 4674
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Tocotrienols Phase 4
10 Tocopherols Phase 4
11 Hormones Phase 4
12 Pharmaceutical Solutions Phase 4
13 Trace Elements Phase 4
14 Micronutrients Phase 4
15 Vitamins Phase 4
16 Nutrients Phase 4
17 Calcium, Dietary Phase 4
18 Calciferol Phase 4
19 Diphosphonates Phase 4
20
Calcium Nutraceutical Phase 4 7440-70-2 271
21
Teriparatide Approved, Investigational Phase 3 52232-67-4 16133850
22
Sodium citrate Approved, Investigational Phase 3 68-04-2
23
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
24
Tamoxifen Approved Phase 3 10540-29-1 2733526
25
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
26
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
27
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
28
Acetaminophen Approved Phase 3 103-90-2 1983
29
Petrolatum Approved, Investigational Phase 3 8009-03-8
30
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
31
tiludronate Approved, Investigational, Vet_approved Phase 3 89987-06-4 60937
32
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
33 Citrate Phase 3
34 Contraceptive Agents, Male Phase 3
35 Contraceptive Agents Phase 3
36 Estrogen Antagonists Phase 3
37 Contraceptives, Oral Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39 Estrogen Receptor Antagonists Phase 3
40 Hormone Antagonists Phase 3
41 Estrogen Receptor Modulators Phase 3
42 Estrogens Phase 3
43
Medroxyprogesterone Phase 3 520-85-4 10631
44 calcium channel blockers Phase 3
45 Sodium Channel Blockers Phase 3
46 Anesthetics Phase 3
47 Analgesics, Non-Narcotic Phase 3
48 Adjuvants, Immunologic Phase 3
49 Analgesics Phase 3
50 Anti-Arrhythmia Agents Phase 3

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3
2 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
3 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
4 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
5 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
6 Efficacy and Security of Annual and Biennial Zoledronic Acid for Osteoporosis Treatment in an HIV-infected Patients' Cohort Completed NCT00795483 Phase 4 Zoledronic acid;Zoledronic acid
7 Preventive Effects of Zoledronic Acid on Bone Metastasis in Patients With Stage IIIB and IV Lung Cancer Unknown status NCT02622607 Phase 3 Zoledronic acid
8 A Pilot Study to Evaluate the Effect of Forsteo (Teriparatide, 1-34-rh-PTH) in Anorexia Nervosa Patients With Low Bone Mineral Density and Increased Bone Fagility (FAN-Trial) Unknown status NCT01801397 Phase 3 osteoanabolic therapy
9 A Randomized Comparison Of Medroxyprogesterone Acetate (MA) And Observation For Prevention Of Endometrial Pathology In Postmenopausal Breast Cancer Patients Treated With Tamoxifen, Phase III Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
10 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
11 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
12 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
13 Topical 5% Imiquimod Cream for Vulvar Paget's Disease: Clinical Efficacy, Safety and Immunological Response Completed NCT02385188 Phase 3 Imiquimod;paracetamol;lidocaine in Vaseline ointment
14 Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced Otosclerosis Terminated NCT01617057 Phase 3 tiludronic acid;Placebo
15 A Multicenter Phase II Study of Docosahexaenoic Acid (DHA) in Patients With a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease Unknown status NCT01849250 Phase 2 Docosahexaenoic Acid
16 Phase II Study of Tandem Cycle Dose-Intense Chemotherapy of Melphalan and Carboplatin, Thiotepa and Cyclophosphamide (STMP V) ± Trastuzumab Followed by Helical Tomotherapy or Local Regional Radiation Therapy for Stage IV Metastatic and Stage IIIB/C Breast Cancer Completed NCT00182793 Phase 2 carboplatin;cyclophosphamide;melphalan;thiotepa
17 The Impact of Bisphosphonates on Bone Loss in Patients Undergoing Surgery and Postoperative Chemotherapy for Gynecologic Malignancies. Completed NCT00593580 Phase 2 placebo;alendronate/cholecalciferol
18 Multicentered, Randomized Study of Safety and Efficacy of Whole-body Vibration as add-on to Standard Pharmacological Treatment of Osteoporosis in Post-menopausal Women Completed NCT01415050 Phase 2
19 A Randomized, Open-label Therapeutic Trial Evaluating the Efficacy and Safety of Neridronate (Nerixia®) in the Treatment of Osteoporosis in Patients With Thalassemia Major and Severe Thalassemia Intermedia. Completed NCT01140321 Phase 2 Neridronate
20 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
21 Randomized Phase II Study of Docetaxel, Adriamycin, and Cytoxan (TAC) Versus Adriamycin/Cytoxan, Followed by Abraxane/Carboplatin (ACAC) +/- Trastuzumab as Neoadjuvant Therapy for Patients With Stage II-III Breast Cancer Active, not recruiting NCT00295893 Phase 2 carboplatin;cyclophosphamide;docetaxel;doxorubicin hydrochloride;paclitaxel
22 Evaluation of Topical Application of Alendronate Sodium In-situ Gel and Recombinant Human Bone Morphogenic Protein 2 on Dental Implant Stability and Crestal Bone Level: A Randomized Controlled Clinical Study Enrolling by invitation NCT04140006 Phase 1, Phase 2 ALN Gel;BMP Gel;Mixed Gel;Control
23 A Phase II Evaluation of Trastuzumab In Patients With HER2 Positive Persistent Or Recurrent Vulvar Paget's Disease Withdrawn NCT01427244 Phase 2 trastuzumab
24 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients. Withdrawn NCT02573038 Phase 2 Aflibercept
25 Phase I Study of a Recombinant Fowl Pox Vaccine rF-CEA (6D)/TRICOM Alone or With GM-CSF in Patients With Advanced CEA Expressing Adenocarinomas Completed NCT00028496 Phase 1
26 A Phase I Study Of Active Immunotherapy With Autologous Dendritic Cells Infected With CEA-6D Expressing Fowlpox -Tricom In Patients With Advanced Or Metastatic Malignancies Expressing CEA Completed NCT00027534 Phase 1
27 A Phase I Study of Active Immunotherapy With Carcinoembryonic Antigen RNA-Pulsed, Autologous Human Cultured Dendritic Cells in Patients With Metastatic Malignancies Expressing Carcinoembryonic Antigen Completed NCT00004604 Phase 1
28 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
29 Osteoporosis in Egypt: Screening Tools' Re-validation and a Local Guide for the Management of the Condition in Males Unknown status NCT03513107
30 Efficacy of a Custom Temporary Foot Orthosis for Plantar Fasciitis Treatment: A Randomized Controlled Trial. Unknown status NCT01882894
31 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance − Completed NCT02106455 Sodium risedronate
32 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
33 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
34 Accelerated Partial Breast Irradiation Completed NCT00599989
35 A Pilot Study of Topical Imiquimod Therapy for the Treatment of Recurrent Extramammary Paget's Disease Completed NCT00504023 imiquimod
36 Vertical Ridge Augmentation Using Titanium Mesh and Allograft in Posterior Mandible: A Feasibility Study Completed NCT02255149
37 A Pilot Study to Determine the Prevalence of Osteoporosis in Patients With Advanced Prostate Cancer Treated With Hormonal Manipulation Completed NCT00124410
38 Videoscopic Versus Open Inguinal Lymphadenectomy for Sentinel Node Positive Cutaneous Malignancies and Genitourinary Staging Procedures Completed NCT01526486
39 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631
40 An Interventional, Phase II, Non Randomized, Mono-centric Study on the Clinical Efficacy and Safety of the Medical Device PAGETEX® as a Photodynamic Therapy Device in the Treatment of Extra-Mammary Paget's Disease of the Vulva (EMPV) Recruiting NCT03713203
41 Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone Recruiting NCT02802384
42 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430
43 Prospective Registry of Gynecologic Patients With Extramammary Paget's Disease Recruiting NCT03564483
44 Examining the Cosmetic Results and Patient Satisfaction Achieved With Skin Reducing Nipple Sparing Mastectomy of Ptotic Breast Followed by Delayed-immediate Submuscular Implant Based- Breast Reconstruction Surgery, and Comparing it to Submuscular Delayed- Immediate Implant- Based Breast Reconstruction Procedures After Skin- Sparing Mastectomy. Response-adaptive, Prospective Randomized Clinical Trial Recruiting NCT04345081
45 Zoledronate In the Prevention of Paget's Disease: Long Term Extension Recruiting NCT03859895
46 Analyses of the Outcome of a Treatment of Vulvar Paget Disease Recruiting NCT03900975
47 Link LCU + Lima Delta TT vs DePuy Corail + Pinnacle. A Comparative Study of Stem and Cup Fixation and Polyethylene Wear Active, not recruiting NCT04064723
48 Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone Terminated NCT00615628
49 Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma Terminated NCT01882231

Search NIH Clinical Center for Mammary Paget's Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Calcitonin
salmon calcitonin

Genetic Tests for Mammary Paget's Disease

Anatomical Context for Mammary Paget's Disease

MalaCards organs/tissues related to Mammary Paget's Disease:

40
Bone, Breast, Skin, Prostate, Lymph Node, Spinal Cord, Testes

Publications for Mammary Paget's Disease

Articles related to Mammary Paget's Disease:

(show top 50) (show all 6679)
# Title Authors PMID Year
1
Apocrine gland carcinoma of the mammary skin concomitant with pagetoid phenomenon. 61 54
20507405 2010
2
[Pigmented Paget's disease of the breast]. 61 54
18374854 2008
3
Cytokeratin 7 staining was useful in a case of pigmented mammary Paget's disease resembling malignant melanoma. 61 54
17040462 2006
4
Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. 61 54
15920545 2005
5
Mammary and extramammary Paget's disease. 54 61
11064666 2000
6
Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. 54 61
9989849 1999
7
c-erbB-2 oncoprotein expression in mammary and extramammary Paget's disease: an immunohistochemical study. 61 54
2173676 1990
8
A rare case of Bowen's disease of the nipple: Literature review and management pathway. 61
32212188 2020
9
Prognostic factors in patients with vulvar cancer: the VULCAN study. 61
32571891 2020
10
[Advances in clinicopathological and genetic studies of mammary Paget's disease]. 61
32486553 2020
11
Invasive cervical adenocarcinoma arising from extension of recurrent vulval Paget's disease. 61
32532900 2020
12
[The surgical treatment of male perineum Paget's disease]. 61
32536091 2020
13
Total Distal Radioulnar Joint Arthroplasty for Paget's Disease of Bone. 61
32509431 2020
14
Invasive vulvar extramammary Paget's disease in the United States. 61
32268952 2020
15
Paget's Disease of Bone and Cardiovascular Risk: a Pilot Study. 61
32516100 2020
16
Perianal Paget's disease: A rare disorder masking an underlying anorectal carcinoma. 61
32278503 2020
17
S-1 in combination with docetaxel as salvage therapy for patients with metastatic extramammary Paget's disease. 61
32540820 2020
18
Isolated Extramammary Paget's Disease of the Unilateral Axilla in a Male Patient: A Case Report. 61
32146095 2020
19
Anal canal adenocarcinoma with pagetoid spread and inguinal lymph node metastasis treated with preoperative chemoradiotherapy: A case report. 61
32337034 2020
20
Using negative control outcomes to assess the comparability of treatment groups among women with osteoporosis in the United States. 61
32537883 2020
21
Bisphosphonate-Induced Osteonecrosis of the Jaws (BIONJ). 61
32346224 2020
22
Bisphosphonates in the management of Paget's disease. 61
32512166 2020
23
Combined serum carcinoembryonic antigen and cytokeratin 19 fragment levels provide a sensitive biomarker for lymph node metastasis in extramammary Paget's disease. 61
32415799 2020
24
Paget disease of the breast: A national retrospective analysis of the US population. 61
32390594 2020
25
Nipple Ultrasound: A Pictorial Essay. 61
32529810 2020
26
[Extramammary Paget's disease: Dermatopathological-dermatoscopic correlation]. 61
32220477 2020
27
Paget's Disease on Bone Mineral Density Examination. 61
32369591 2020
28
Management of Paget's disease of bone. 61
31848640 2020
29
Outcomes in extramammary Paget's disease patients with brain metastasis: a retrospective analysis. 61
32450098 2020
30
Experiences with Surgical Reconstruction of Penoscrotal Extramammary Paget's Disease: A review of 21 cases. 61
32563670 2020
31
Outcomes of lymph node dissection in the treatment of extramammary Paget's disease: A single-institution study. 61
32157716 2020
32
[X-ray external irradiation combined with γ-ray implantation for extramammary Paget's disease: a case report]. 61
32482036 2020
33
The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease. 61
32457396 2020
34
History of risedronate. 61
32387834 2020
35
Cutaneous Breast Cancer Metastases Successfully Treated Using an Oxygen Flow Assisted Topical Administration of Methotrexate (OFAMTX). 61
32415574 2020
36
History of etidronate. 61
31911206 2020
37
Gastrointestinal involvement of primary skin diseases. 61
32455473 2020
38
p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. 61
32324396 2020
39
[Pathology of the nipple-areola complex : I. Paget's disease of the nipple, variants, and differential diagnoses]. 61
32405655 2020
40
Extramammary Paget's Disease and Melanoma: 2 Cases of Double Cancers. 61
32518542 2020
41
Osteoclast signaling-targeting miR-146a-3p and miR-155-5p are downregulated in Paget's disease of bone. 61
32485219 2020
42
A review on osteoclast diseases and osteoclastogenesis inhibitors recently developed from natural resources. 61
31954740 2020
43
Pelvic/Perineal Reconstruction: Time to Consider the Anterolateral Thigh Flap as a First-line Option? 61
32440406 2020
44
Mammary Paget's Disease of the Male Breast: A Rare Case With an Unusual Immunohistochemical Profile. 61
31514589 2020
45
Clinicopathological characteristics of mammary Paget's disease: A single-center 25-year experience in Korea. 61
31749265 2020
46
Drp1 expression levels correlate with clinical stage in extramammary Paget's disease. 61
32249451 2020
47
Bilateral Paget's Disease of the Breast in a Patient with CHEK2 Mutation. 61
32285038 2020
48
Primary and revision total hip arthroplasty with uncemented acetabular components in patients with Paget's disease. 61
32340487 2020
49
Weekly docetaxel monotherapy for metastatic extramammary Paget's disease: Retrospective single-institute analysis. 61
32020662 2020
50
Bone metastases could be predictive factors of central nervous system metastases in extramammary Paget's disease. 61
32056255 2020

Variations for Mammary Paget's Disease

Expression for Mammary Paget's Disease

Search GEO for disease gene expression data for Mammary Paget's Disease.

Pathways for Mammary Paget's Disease

GO Terms for Mammary Paget's Disease

Cellular components related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.53 VCP TNFSF11 SQSTM1 PGR MUC1 KRT8
2 intermediate filament GO:0005882 9.26 KRT8 KRT7 KRT20 KRT14

Biological processes related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.67 KRT8 KRT7 KRT20 KRT14
2 cellular response to growth factor stimulus GO:0071363 9.63 ERBB2 EGFR BGLAP
3 response to estrogen GO:0043627 9.61 TNFRSF11B ESR1 BGLAP
4 positive regulation of MAP kinase activity GO:0043406 9.58 TNFSF11 ERBB2 EGFR
5 positive regulation of protein kinase B signaling GO:0051897 9.46 TNFSF11 ESR1 ERBB2 EGFR
6 paracrine signaling GO:0038001 9.32 TNFSF11 PGR
7 negative regulation of ERBB signaling pathway GO:1901185 9.26 ERBB2 EGFR
8 cornification GO:0070268 9.26 KRT8 KRT7 KRT20 KRT14
9 response to hydroxyisoflavone GO:0033594 8.62 EGFR BGLAP

Molecular functions related to Mammary Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.55 VCP SQSTM1 KRT8 EGFR CALCA
2 protein phosphatase binding GO:0019903 9.54 VCP ERBB2 EGFR
3 ATPase binding GO:0051117 9.5 PGR ESR1 EGFR
4 enzyme binding GO:0019899 9.35 SQSTM1 PGR ESR1 EGFR CFTR
5 nitric-oxide synthase regulator activity GO:0030235 9.26 ESR1 EGFR
6 identical protein binding GO:0042802 9.23 VCP TNFSF11 SQSTM1 PGR ESR1 ERBB2

Sources for Mammary Paget's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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