Aliases & Classifications for Mammographic Density

MalaCards integrated aliases for Mammographic Density:

Name: Mammographic Density 57 70

External Ids:

OMIM® 57 607308
UMLS 70 C1846502

Summaries for Mammographic Density

MalaCards based summary : Mammographic Density is related to hypertrophy of breast and insulin-like growth factor i. An important gene associated with Mammographic Density is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Glucose / Energy Metabolism. The drugs Tamoxifen and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and lymph node, and related phenotypes are adipose tissue and endocrine/exocrine gland

Wikipedia : 73 Breast cancer screening is the medical screening of asymptomatic, apparently healthy women for breast... more...

More information from OMIM: 607308

Related Diseases for Mammographic Density

Diseases related to Mammographic Density via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 hypertrophy of breast 29.9 ESR1 CYP19A1
2 insulin-like growth factor i 29.9 IGFBP3 IGFBP1 IGF1 ESR1
3 amenorrhea 29.9 IGF1 CYP19A1 CYP17A1
4 endometrial hyperplasia 29.8 ESR1 CYP19A1 CYP17A1
5 female breast cancer 29.4 IGFBP3 IGF1 ESR1 CYP1A1 CYP19A1
6 infertility 29.0 IGFBP1 ESR1 CYP1A1 CYP19A1
7 breast disease 28.8 IGFBP3 IGFBP1 IGF1 ESR1 CYP1B1 CYP1A1
8 endometriosis 28.2 IGFBP1 HSD17B1 ESR1 CYP1B1 CYP1A1 CYP19A1
9 breast cancer 28.0 LSP1 IGFBP3 IGFBP1 IGF1 HSD17B1 ESR1
10 body mass index quantitative trait locus 1 10.5
11 in situ carcinoma 10.5
12 ductal carcinoma in situ 10.4
13 mixed epithelial stromal tumour 10.3 CYP1B1 COMT
14 traumatic brain injury 10.3 IGF1 COMT
15 brain injury 10.3 IGF1 COMT
16 slipped capital femoral epiphysis 10.3 IGFBP3 IGF1
17 secondary adrenal insufficiency 10.3 IGFBP3 IGF1
18 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.2 IGFBP3 IGF1
19 potter's syndrome 10.2 IGFBP3 IGF1
20 marasmus 10.2 IGFBP3 IGF1
21 central precocious puberty 10.2 IGFBP3 IGF1
22 penis agenesis 10.2 IGFBP3 CYP17A1
23 fetal macrosomia 10.2 IGFBP3 IGF1
24 skin tag 10.2 IGFBP3 IGF1
25 empty sella syndrome 10.2 IGFBP3 IGF1
26 transsexualism 10.2 CYP19A1 CYP17A1
27 hyperpituitarism 10.2 IGFBP3 IGF1
28 mixed cell adenoma 10.2 IGF1 ESR1
29 premature ejaculation 10.2 CYP19A1 COMT
30 pituitary adenoma 1, multiple types 10.2 IGFBP3 IGF1
31 donohue syndrome 10.1 IGFBP3 IGF1
32 severe combined immunodeficiency 10.1
33 diffuse idiopathic skeletal hyperostosis 10.1 IGFBP3 IGF1
34 hypothalamic obesity 10.1 IGF1 HSD17B1
35 complete androgen insensitivity syndrome 10.1 IGFBP3 CYP19A1
36 juvenile nasopharyngeal angiofibroma 10.1 ESR1 CYP19A1
37 androgenic alopecia 10.1 IGF1 CYP19A1
38 progesterone-receptor positive breast cancer 10.1 ESR1 CYP19A1
39 phimosis 10.1 CYP1B1 CYP1A1
40 vaginal discharge 10.1 ESR1 CYP19A1
41 vaginal adenoma 10.1 CYP1A1 CYP19A1
42 vaginal benign neoplasm 10.1 CYP1A1 CYP19A1
43 estrogen excess 10.1 ESR1 CYP19A1
44 acid-labile subunit deficiency 10.1 IGFBP3 IGF1
45 lobular neoplasia 10.0
46 sporadic breast cancer 10.0
47 46,xy sex reversal 2 10.0 CYP19A1 CYP17A1
48 pediatric osteosarcoma 10.0 IGFBP3 IGF1
49 mccune-albright syndrome 10.0 IGFBP3 IGF1 CYP19A1
50 endometriosis of ovary 10.0 ESR1 CYP19A1

Graphical network of the top 20 diseases related to Mammographic Density:



Diseases related to Mammographic Density

Symptoms & Phenotypes for Mammographic Density

Clinical features from OMIM®:

607308 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Mammographic Density:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.63 CYP17A1 CYP19A1 ESR1 HSD17B1 IGF1 IGFBP3
2 endocrine/exocrine gland MP:0005379 9.5 COMT CYP19A1 CYP1A1 ESR1 HSD17B1 IGF1
3 homeostasis/metabolism MP:0005376 9.28 COMT CYP17A1 CYP19A1 CYP1A1 CYP1B1 ESR1

Drugs & Therapeutics for Mammographic Density

Drugs for Mammographic Density (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 1, Phase 2 10540-29-1 2733526
2
Denosumab Approved Phase 2 615258-40-7
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
4
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 5280795 6221
5
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2 83-88-5 493570
6 Hormone Antagonists Phase 1, Phase 2
7 Estrogens Phase 1, Phase 2
8 Antineoplastic Agents, Hormonal Phase 1, Phase 2
9 Estrogen Receptor Antagonists Phase 1, Phase 2
10 Estrogen Antagonists Phase 1, Phase 2
11 Estrogen Receptor Modulators Phase 1, Phase 2
12 Hormones Phase 2
13 Trace Elements Phase 2
14 Nutrients Phase 2
15 Calciferol Phase 2
16 Micronutrients Phase 2
17 Pharmaceutical Solutions Phase 2
18 Vitamins Phase 2
19 Soy Bean Phase 2
20 Vitamin B2 Phase 2
21 Phytoestrogens Phase 2
22 Calcium, Dietary Phase 2
23
Calcium Nutraceutical Phase 2 7440-70-2 271
24
Anastrozole Approved, Investigational Phase 1 120511-73-1 2187
25
Testosterone Approved, Investigational Phase 1 58-22-0 6013
26
Methyltestosterone Approved Phase 1 58-18-4 6010
27
Testosterone undecanoate Approved, Investigational Phase 1 5949-44-0
28
Testosterone enanthate Approved Phase 1 315-37-7 9416
29 Androgens Phase 1
30 Aromatase Inhibitors Phase 1
31 Anabolic Agents Phase 1
32 Testosterone 17 beta-cypionate Phase 1
33
Metformin Approved 657-24-9 4091 14219
34
Polyestradiol phosphate Approved 28014-46-2
35
Progesterone Approved, Vet_approved 57-83-0 5994
36
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
37
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
38
Bisphenol A Experimental 80-05-7 6623
39 Omega 3 Fatty Acid
40 Vitamin D2
41 Ergocalciferols
42 Hypoglycemic Agents
43 Estradiol 3-benzoate
44 Estradiol 17 beta-cypionate
45 Progestins
46 Estrogens, Conjugated (USP)

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Randomized, Open Pilot Study to Investigate the Mammographic Density Reduction on Healthy Women, Within the Karma Cohort, for Two Different Doses of Tamoxifen Completed NCT04079517 Phase 1, Phase 2 Tamoxifen
2 Randomized Clinical Trial of RANKL Inhibition With Denosumab on Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT) Recruiting NCT04067726 Phase 2 Denosumab;Placebo;Calcium;Vitamin D3
3 Mammographic Density and Soy Isoflavones Active, not recruiting NCT00204490 Phase 2
4 A Single-Centre Pilot Trial Investigating the Efficacy and Safety of Enobosarm and Anastrozole in Pre-menopausal Women With High Mammographic Breast Density Completed NCT03264651 Phase 1 enobosarm
5 A Single Dose Trial to Evaluate the Pharmacokinetics of Testosterone and Anastrozole From Subcutaneous Testosterone and Anastrozole (T+Ai) in Premenopausal Women Completed NCT03314298 Phase 1 testosterone anastrozole
6 The Malaysian Soy and Mammographic Density (MiSo) Study: A Randomized, Three-arm, Controlled Clinical Trial to Investigate the Impact of Soy Isoflavone Intake on Mammographic Density as a Biomarker of Breast Cancer Risk Unknown status NCT03686098
7 Role of Diffusion Magnetic Resonance Imaging in Assessment of Mammographically Detected Asymmetric Densities Unknown status NCT03696147
8 THE EFFECTS OF VITAMIN D ON MAMMOGRAPHIC DENSITY AND BREAST TISSUE Unknown status NCT02239874
9 Change in Mammographic Density With Metformin Use: A Companion Study to NCIC Study MA.32 Unknown status NCT01666171 metformin hydrochloride
10 KEEPS Mammographic Density And Breast Health Ancillary Study Completed NCT02524561 CEE pill;Estradiol patch;Active Progesterone
11 Longitudinal Changes in Mammographic Density and Risk of Breast Cancer Completed NCT00445445
12 A Study of Breast Cancer, Breast Disease, Mammographic Density and Pesticides Among a Population From Triana, Alabama Completed NCT00341315
13 Mammographic Density and the Risk of Tumor Recurrence in Asian Women: a Case-control Study Completed NCT02771665
14 Total Xenoestrogen Body Burden in Relation to Mammographic Density, a Marker of Breast Cancer Risk Completed NCT00839696
15 Pilot Study to Examine Histological Characteristics of Mammographic Density With Molecular Breast Imaging: Part 2 - Premenopausal Women Completed NCT01588834
16 What Are the Benefits and Harms of Risk Stratified Screening as Part of the NHS Breast Screening Programme: Study Protocol for a Multi-site Non-randomised Comparison of BC-Predict Versus Usual Screening Active, not recruiting NCT04359420
17 Pilot Study to Examine Histological Characteristics of Mammographic Density With Molecular Breast Imaging: Part 1 - Postmenopausal Women Enrolling by invitation NCT01240278

Search NIH Clinical Center for Mammographic Density

Genetic Tests for Mammographic Density

Anatomical Context for Mammographic Density

MalaCards organs/tissues related to Mammographic Density:

40
Breast, Bone, Lymph Node, Thyroid, Skin, Pituitary

Publications for Mammographic Density

Articles related to Mammographic Density:

(show top 50) (show all 1203)
# Title Authors PMID Year
1
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. 57 61
26073781 2015
2
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. 57 61
21278746 2011
3
Heritability of mammographic density, a risk factor for breast cancer. 61 57
12239257 2002
4
Novel mammogram-based measures improve breast cancer risk prediction beyond an established mammographic density measure. 61
33197272 2021
5
The Impact of Preoperative Breast MRI on Surgical Margin Status in Breast Cancer Patients Recalled at Biennial Screening Mammography: An Observational Cohort Study. 61
33796997 2021
6
Radiological review of prior screening mammograms of screen-detected breast cancer. 61
33001307 2021
7
Less Is More-Ways to Move Forward for Improved Breast Cancer Risk Stratification. 61
33811169 2021
8
Occupation, occupational exposures and mammographic density in Spanish women. 61
33524328 2021
9
Simplified Breast Risk Tool Integrating Questionnaire Risk Factors, Mammographic Density, and Polygenic Risk Score: Development and Validation. 61
33277321 2021
10
Low-Dose Tamoxifen for Mammographic Density Reduction: A Randomized Controlled Trial. 61
33734864 2021
11
Circulating carotenoids and breast cancer among high-risk individuals. 61
33236056 2021
12
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. 61
32755210 2021
13
Mammographic density as an image-based biomarker of therapy response in neoadjuvant-treated breast cancer patients. 61
33377172 2021
14
Predictors of mammographic microcalcifications. 61
32949149 2021
15
Density map and fuzzy classification for breast density by using BI-RADS. 61
33190944 2021
16
Effects of progestogens used in menopause hormone therapy on the normal breast and benign breast disease in postmenopausal women. 61
33733982 2021
17
[Mammographic density patterns in women from Torreon, Coahuila]. 61
33667045 2021
18
Comparison of two-dimensional synthesized mammograms versus original digital mammograms: a quantitative assessment. 61
33447988 2021
19
Platelet Activation In Situ in Breasts at High Risk of Cancer: Relationship with Mammographic Density and Estradiol. 61
33180937 2021
20
Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes. 61
33392844 2021
21
Random effects models of lymph node metastases in breast cancer: quantifying the roles of covariates and screening using a continuous growth model. 61
33501643 2021
22
Breast density, benign breast disease, and risk of breast cancer over time. 61
33409776 2021
23
Association of Interactions Between Mammographic Density Phenotypes and Established Risk Factors With Breast Cancer Risk, by Tumor Subtype and Menopausal Status. 61
32639533 2021
24
Mammographic density changes following BC treatment. 61
33578136 2021
25
Use of Low-Dose Tamoxifen to Increase Mammographic Screening Sensitivity in Premenopausal Women. 61
33467653 2021
26
Pten regulates collagen fibrillogenesis by fibroblasts through SPARC. 61
33534863 2021
27
Single nucleotide polymorphisms of insulin-like growth factor gene and mammographic breast density. 61
33488326 2020
28
Association between changes in mammographic density category and the risk of breast cancer: A nationwide cohort study in East-Asian women. 61
33368233 2020
29
The association between breast cancer risk factors and background parenchymal enhancement at dynamic contrast-enhanced breast MRI. 61
32216451 2020
30
Pubertal mammary gland development is a key determinant of adult mammographic density. 61
33309487 2020
31
Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses. 61
33188991 2020
32
Evaluation of the association between mammographic density and the risk of breast cancer using Quantra software and the BI-RADS classification. 61
33181680 2020
33
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. 61
32721948 2020
34
Breast cancer risk factors and their effects on survival: a Mendelian randomisation study. 61
33198768 2020
35
ESR1 gene variants, haplotypes and diplotypes may influence the risk of breast cancer and mammographic density. 61
33099762 2020
36
Comparing recall rates following implementation of digital breast tomosynthesis to synthetic 2D images and digital mammography on women with breast-conserving surgery. 61
32529566 2020
37
Assessing breast cancer risk within the general screening population: developing a breast cancer risk model to identify higher risk women at mammographic screening. 61
32358648 2020
38
Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk. 61
33037222 2020
39
Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden. 61
32563178 2020
40
Mammographic density and breast cancer screening. 61
32643449 2020
41
Evaluation of background parenchymal enhancement in breast contrast-enhanced ultrasound with Sonazoid®. 61
32989596 2020
42
Serum Phospholipid Fatty Acids and Mammographic Density in Premenopausal Women. 61
32584993 2020
43
Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years. 61
32993747 2020
44
Fully automated measurements of volumetric breast density adapted for BIRADS 5th edition: a comparison with visual assessment. 61
32910685 2020
45
Breast density, MR imaging biomarkers, and breast cancer risk. 61
32654416 2020
46
Is mammographic density a marker of breast cancer phenotypes? 61
32410205 2020
47
Key steps for effective breast cancer prevention. 61
32528185 2020
48
A Review of Breast Density Implications and Breast Cancer Screening. 61
32334975 2020
49
Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors. 61
32838791 2020
50
No association between night shiftwork and mammographic density. 61
32467312 2020

Variations for Mammographic Density

Expression for Mammographic Density

Search GEO for disease gene expression data for Mammographic Density.

Pathways for Mammographic Density

Pathways related to Mammographic Density according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 CYP1B1 CYP1A1 CYP19A1 CYP17A1 COMT
2 12.3 IGFBP3 IGFBP1 CYP19A1 CYP17A1
3
Show member pathways
12.15 IGFBP3 IGFBP1 IGF1
4
Show member pathways
11.66 CYP1B1 CYP1A1 CYP19A1
5
Show member pathways
11.57 HSD17B1 CYP19A1 CYP17A1
6
Show member pathways
11.39 HSD17B1 CYP1A1 CYP19A1 CYP17A1 COMT
7 11.31 IGFBP1 CYP1B1 CYP1A1
8 11.29 ESR1 CYP1B1 CYP1A1
9
Show member pathways
11.26 HSD17B1 CYP1B1 CYP1A1 CYP19A1 CYP17A1 COMT
10
Show member pathways
11.17 CYP1B1 CYP1A1
11 11.14 IGFBP3 IGFBP1
12 11.14 CYP1B1 CYP1A1
13
Show member pathways
11.1 CYP1B1 CYP1A1
14
Show member pathways
11.09 HSD17B1 CYP1B1 CYP1A1 CYP19A1 COMT
15 10.9 IGFBP3 IGFBP1 IGF1
16
Show member pathways
10.87 HSD17B1 CYP17A1
17 10.81 IGF1 HSD17B1 CYP1B1 CYP1A1 CYP19A1 CYP17A1
18 10.66 ESR1 CYP1B1 CYP1A1
19 10.18 HSD17B1 CYP19A1
20 10.1 HSD17B1 ESR1 CYP19A1

GO Terms for Mammographic Density

Cellular components related to Mammographic Density according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.65 CYP1B1 CYP1A1 CYP19A1 CYP17A1 COMT
2 insulin-like growth factor ternary complex GO:0042567 9.16 IGFBP3 IGF1
3 insulin-like growth factor binding protein complex GO:0016942 8.96 IGFBP3 IGF1
4 organelle membrane GO:0031090 8.92 CYP1B1 CYP1A1 CYP19A1 CYP17A1

Biological processes related to Mammographic Density according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.72 HSD17B1 CYP1B1 CYP1A1 CYP19A1 CYP17A1
2 cellular protein metabolic process GO:0044267 9.71 IGFBP3 IGFBP1 IGF1
3 steroid metabolic process GO:0008202 9.63 CYP1B1 CYP1A1 CYP17A1
4 developmental process GO:0032502 9.52 CYP1A1 COMT
5 negative regulation of smooth muscle cell proliferation GO:0048662 9.51 IGFBP3 COMT
6 sterol metabolic process GO:0016125 9.49 CYP1B1 CYP19A1
7 epoxygenase P450 pathway GO:0019373 9.48 CYP1B1 CYP1A1
8 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.43 IGFBP3 IGF1
9 estrogen biosynthetic process GO:0006703 9.4 HSD17B1 CYP19A1
10 omega-hydroxylase P450 pathway GO:0097267 9.37 CYP1B1 CYP1A1
11 toxin metabolic process GO:0009404 9.26 CYP1B1 CYP1A1
12 steroid biosynthetic process GO:0006694 9.26 HSD17B1 CYP1A1 CYP19A1 CYP17A1
13 regulation of insulin-like growth factor receptor signaling pathway GO:0043567 9.16 IGFBP3 IGFBP1
14 estrogen metabolic process GO:0008210 8.92 HSD17B1 CYP1B1 CYP1A1 COMT

Molecular functions related to Mammographic Density according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.83 HSD17B1 CYP1B1 CYP1A1 CYP19A1 CYP17A1
2 heme binding GO:0020037 9.71 CYP1B1 CYP1A1 CYP19A1 CYP17A1
3 lyase activity GO:0016829 9.69 CYP1B1 CYP1A1 CYP17A1
4 iron ion binding GO:0005506 9.67 CYP1B1 CYP1A1 CYP19A1 CYP17A1
5 steroid hydroxylase activity GO:0008395 9.55 CYP1A1 CYP19A1
6 steroid binding GO:0005496 9.54 HSD17B1 ESR1
7 insulin-like growth factor binding GO:0005520 9.52 IGFBP3 IGFBP1
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.5 CYP1B1 CYP1A1 CYP19A1
9 insulin-like growth factor I binding GO:0031994 9.49 IGFBP3 IGFBP1
10 estrogen 16-alpha-hydroxylase activity GO:0101020 9.48 CYP1B1 CYP1A1
11 insulin-like growth factor II binding GO:0031995 9.46 IGFBP3 IGFBP1
12 monooxygenase activity GO:0004497 9.46 CYP1B1 CYP1A1 CYP19A1 CYP17A1
13 aromatase activity GO:0070330 9.43 CYP1B1 CYP1A1 CYP19A1
14 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP1B1 CYP1A1 CYP19A1 CYP17A1
15 oxygen binding GO:0019825 8.92 CYP1B1 CYP1A1 CYP19A1 CYP17A1

Sources for Mammographic Density

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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