MCID: MND001
MIFTS: 32

Mandibular Cancer

Categories: Cancer diseases, Bone diseases, Oral diseases

Aliases & Classifications for Mandibular Cancer

MalaCards integrated aliases for Mandibular Cancer:

Name: Mandibular Cancer 12 15
Mandibular Neoplasms 44 73
Malignant Neoplasm of Inferior Maxilla 12
Malignant Neoplasm of Lower Jaw Bone 12
Malignant Neoplasm of Mandible 12
Neoplasm of Mandible 12
Mandibular Neoplasm 12
Mandible Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2338
ICD10 33 C41.1
ICD9CM 35 170.1
MeSH 44 D008339
NCIt 50 C35178

Summaries for Mandibular Cancer

Disease Ontology : 12 A jaw cancer and mandibular disease that affects your lower jawbone.

MalaCards based summary : Mandibular Cancer, also known as mandibular neoplasms, is related to syringoma and myoepithelioma. An important gene associated with Mandibular Cancer is ST7 (Suppression Of Tumorigenicity 7), and among its related pathways/superpathways are Rheumatoid arthritis and Differentiation Pathway. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mandibular Cancer

Graphical network of the top 20 diseases related to Mandibular Cancer:



Diseases related to Mandibular Cancer

Symptoms & Phenotypes for Mandibular Cancer

GenomeRNAi Phenotypes related to Mandibular Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.36 ST7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.36 TNFSF11 CSF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.36 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.36 TNFSF11 CSF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.36 CSF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.36 ST7 TNFSF11 CSF1

Drugs & Therapeutics for Mandibular Cancer

Drugs for Mandibular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
2 Anesthetics Not Applicable
3 Anesthetics, Local Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Inferior Alveolar Nerve Block for Intraoperative Analgesia for Maxillofacial Cancer Surgery - RCT Completed NCT02745288 Not Applicable
2 Three-Dimensional Printing of Patient-Specific Titanium Plates in Jaw Surgery: A Pilot Study Recruiting NCT03057223 Not Applicable
3 Comparison Between Internal and External Distractors in Osteogenesis Not yet recruiting NCT03540329 Not Applicable

Search NIH Clinical Center for Mandibular Cancer

Cochrane evidence based reviews: mandibular neoplasms

Genetic Tests for Mandibular Cancer

Anatomical Context for Mandibular Cancer

MalaCards organs/tissues related to Mandibular Cancer:

41
Bone

Publications for Mandibular Cancer

Articles related to Mandibular Cancer:

# Title Authors Year
1
Bite Force and Masticatory Performance Using Implant-supported Overdentures After Treatment of Mandibular Cancer. ( 27466516 )
2016
2
Evaluation of Masticatory Efficiency and QoL Improvements After Prosthetic Rehabilitation of Mandibular Cancer Patients Reconstructed with a Fibula Free Flap. ( 26218029 )
2015
3
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. ( 21549478 )
2011
4
The use of cone beam computed tomography as an aid in evaluating and treatment planning for mandibular cancer. ( 17368377 )
2007
5
Is nasotracheal intubation safe in surgery for mandibular cancer? ( 1627294 )
1992

Variations for Mandibular Cancer

Expression for Mandibular Cancer

Search GEO for disease gene expression data for Mandibular Cancer.

Pathways for Mandibular Cancer

Pathways related to Mandibular Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 CSF1 CTSL TNFSF11
2 10.64 CSF1 TNFSF11

GO Terms for Mandibular Cancer

Cellular components related to Mandibular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CSF1 CTSL CTSS SERPINB5 TNFSF11
2 extracellular space GO:0005615 9.35 CSF1 CTSL CTSS SERPINB5 TNFSF11
3 lysosome GO:0005764 9.33 CTSL CTSS GFAP
4 lysosomal lumen GO:0043202 9.32 CTSL CTSS
5 endolysosome lumen GO:0036021 8.62 CTSL CTSS

Biological processes related to Mandibular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.46 CTSL CTSS
2 collagen catabolic process GO:0030574 9.43 CTSL CTSS
3 proteolysis involved in cellular protein catabolic process GO:0051603 9.4 CTSL CTSS
4 toll-like receptor signaling pathway GO:0002224 9.37 CTSL CTSS
5 antigen processing and presentation GO:0019882 9.32 CTSL CTSS
6 osteoclast differentiation GO:0030316 9.26 CSF1 TNFSF11
7 positive regulation of osteoclast differentiation GO:0045672 9.16 CSF1 TNFSF11
8 cellular response to thyroid hormone stimulus GO:0097067 8.96 CTSL CTSS
9 osteoclast proliferation GO:0002158 8.62 CSF1 TNFSF11

Molecular functions related to Mandibular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen binding GO:0005518 9.26 CTSL CTSS
2 cysteine-type endopeptidase activity GO:0004197 9.16 CTSL CTSS
3 fibronectin binding GO:0001968 8.96 CTSL CTSS
4 proteoglycan binding GO:0043394 8.62 CTSL CTSS

Sources for Mandibular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....