MCID: MNG007
MIFTS: 28

Manganese Poisoning

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Manganese Poisoning

MalaCards integrated aliases for Manganese Poisoning:

Name: Manganese Poisoning 59 17
Manganese Intoxication 59
Manganism 59

Characteristics:

Orphanet epidemiological data:

59
manganese poisoning
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 34 T57.2
UMLS via Orphanet 73 C0677050
Orphanet 59 ORPHA306682

Summaries for Manganese Poisoning

MalaCards based summary : Manganese Poisoning, also known as manganese intoxication, is related to hair whorl and suppressor of tumorigenicity 3. The drug Manganese has been mentioned in the context of this disorder. Affiliated tissues include brain, liver and globus pallidus, and related phenotypes are emotional lability and gait disturbance

Wikipedia : 75 Manganism or manganese poisoning is a toxic condition resulting from chronic exposure to manganese. It... more...

Related Diseases for Manganese Poisoning

Diseases related to Manganese Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 hair whorl 10.3
2 suppressor of tumorigenicity 3 10.1
3 human immunodeficiency virus type 1 10.1
4 insulinoma 10.1
5 dystonia 10.1
6 tremor 10.1
7 chorea, childhood-onset, with psychomotor retardation 10.0
8 choreatic disease 10.0
9 amyotrophic lateral sclerosis 1 10.0
10 huntington disease 10.0
11 thyroid cancer, nonmedullary, 1 10.0
12 pancreatic cancer 10.0
13 hypermanganesemia with dystonia 1 10.0
14 fatty liver disease, nonalcoholic 1 10.0
15 pancreatic cancer 3 10.0
16 common cold 10.0
17 pica disease 10.0
18 diarrhea 10.0
19 lateral sclerosis 10.0
20 iron metabolism disease 10.0
21 agammaglobulinemia 10.0
22 bilirubin metabolic disorder 10.0
23 acute kidney failure 10.0
24 ischemia 10.0
25 central nervous system disease 10.0
26 thyroid gland papillary carcinoma 10.0
27 movement disease 10.0
28 pneumonia 10.0
29 kidney disease 10.0
30 prion disease 10.0
31 b-cell lymphoma 10.0
32 polycythemia 10.0
33 rubella 10.0
34 dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease 10.0
35 autonomic dysfunction 10.0
36 myoclonus 10.0
37 thyroid carcinoma 10.0
38 ataxia and polyneuropathy, adult-onset 9.9
39 antisocial personality disorder 9.9
40 visual epilepsy 9.9
41 personality disorder 9.9
42 conversion disorder 9.9
43 substance abuse 9.9
44 liver disease 9.9
45 pancreatitis 9.9
46 learning disability 9.9
47 encephalopathy 9.9
48 seizure disorder 9.9
49 parkinson disease, late-onset 9.9
50 neuroblastoma 1 9.9

Graphical network of the top 20 diseases related to Manganese Poisoning:



Diseases related to Manganese Poisoning

Symptoms & Phenotypes for Manganese Poisoning

Human phenotypes related to Manganese Poisoning:

59 32 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 emotional lability 59 32 hallmark (90%) Very frequent (99-80%) HP:0000712
2 gait disturbance 59 32 hallmark (90%) Very frequent (99-80%) HP:0001288
3 hypertonia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001276
4 memory impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0002354
5 dystonia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001332
6 abnormality of mitochondrial metabolism 59 32 hallmark (90%) Very frequent (99-80%) HP:0003287
7 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
8 postural tremor 59 32 hallmark (90%) Very frequent (99-80%) HP:0002174
9 bradykinesia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002067
10 postural instability 59 32 hallmark (90%) Very frequent (99-80%) HP:0002172
11 cogwheel rigidity 59 32 hallmark (90%) Very frequent (99-80%) HP:0002396
12 sleep-wake cycle disturbance 59 32 hallmark (90%) Very frequent (99-80%) HP:0006979
13 abnormal globus pallidus morphology 59 32 hallmark (90%) Very frequent (99-80%) HP:0002453
14 increased reactive oxygen species production 59 32 hallmark (90%) Very frequent (99-80%) HP:0025464
15 visual impairment 59 32 frequent (33%) Frequent (79-30%) HP:0000505
16 aggressive behavior 59 32 frequent (33%) Frequent (79-30%) HP:0000718
17 obsessive-compulsive behavior 59 32 frequent (33%) Frequent (79-30%) HP:0000722
18 confusion 59 32 frequent (33%) Frequent (79-30%) HP:0001289
19 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
20 delusions 59 32 frequent (33%) Frequent (79-30%) HP:0000746
21 akinesia 59 32 frequent (33%) Frequent (79-30%) HP:0002304
22 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
23 decreased male libido 59 32 frequent (33%) Frequent (79-30%) HP:0040306
24 inappropriate laughter 59 32 frequent (33%) Frequent (79-30%) HP:0000748
25 depressivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0000716
26 hallucinations 59 32 occasional (7.5%) Occasional (29-5%) HP:0000738
27 irritability 59 32 occasional (7.5%) Occasional (29-5%) HP:0000737
28 hypersexuality 59 32 occasional (7.5%) Occasional (29-5%) HP:0030214
29 abnormality of extrapyramidal motor function 59 Very frequent (99-80%)
30 impairment in personality functioning 59 Occasional (29-5%)

Drugs & Therapeutics for Manganese Poisoning

Drugs for Manganese Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Manganese Approved, Nutraceutical 7439-96-5 27854

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Determine the Effectiveness of Convective Uses of Basket Wires for the Maintenance of Stone and Pneumatic Probe in the Treatment of Ureteral Stones Completed NCT03980444

Search NIH Clinical Center for Manganese Poisoning

Genetic Tests for Manganese Poisoning

Anatomical Context for Manganese Poisoning

MalaCards organs/tissues related to Manganese Poisoning:

41
Brain, Liver, Globus Pallidus, Testes, Skin, Thyroid, Olfactory Bulb

Publications for Manganese Poisoning

Articles related to Manganese Poisoning:

(show top 50) (show all 505)
# Title Authors PMID Year
1
Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism. 38
30357569 2019
2
The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors. 38
30481588 2019
3
Mn-Induced Neurocytes Injury and Autophagy Dysfunction in Alpha-Synuclein Wild-Type and Knock-Out Mice: Highlighting the Role of Alpha-Synuclein. 38
30796692 2019
4
Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats. 38
31109603 2019
5
Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats. 38
31216744 2019
6
Manganism without Parkinsonism: Isolated Unilateral Upper Limb Tremor in a Welder. 38
30944287 2019
7
Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease. 38
30790043 2019
8
Overexpression of miR-138-5p suppresses MnCl2 -induced autophagy by targeting SIRT1 in SH-SY5Y cells. 38
30672645 2019
9
The neuroprotective properties of carnosine in a mouse model of manganism is mediated via mitochondria regulating and antioxidative mechanisms. 38
30856059 2019
10
The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics. 38
30851309 2019
11
Teaching NeuroImages: An imaging clue for treatable early childhood-onset dystonia: Manganism. 38
30718332 2019
12
Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation. 38
31293375 2019
13
LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. 38
30645642 2019
14
[Functional annotation of differentially expressed genes in manganese-poisoned rats and related metabolic pathways]. 38
30812084 2018
15
Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects. 38
30300793 2018
16
Exploration of the establishment of manganese poisoning rat model and analysis of discriminant methods. 38
30118795 2018
17
Manganese toxicity is targeting an early step in the dopamine signal transduction pathway that controls lateral cilia activity in the bivalve mollusc Crassostrea virginica. 38
30010023 2018
18
Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats. 38
30607343 2018
19
Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control. 38
30040983 2018
20
In vitro meningeal permeation of MnFe2O4 nanoparticles. 38
30053450 2018
21
Environmentally relevant manganese overexposure alters neural cell morphology and differentiation in vitro. 38
29486219 2018
22
Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. 38
29778792 2018
23
Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats. 38
29671021 2018
24
Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation. 38
29673961 2018
25
Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies. 38
29685658 2018
26
B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency. 38
29887684 2018
27
17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. 38
29183790 2018
28
Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization. 38
29193611 2018
29
Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy. 38
29408508 2018
30
[The comparison of neurobehavioral changes and impaired locations between the mouse model of manganism and Parkinson's disease]. 38
29699003 2018
31
The Impact of Environmental Mn Exposure on Insect Biology. 38
29545824 2018
32
Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. 38
28610743 2018
33
Sodium P-aminosalicylic acid inhibits sub-chronic manganese-induced neuroinflammation in rats by modulating MAPK and COX-2. 38
28651968 2018
34
The early history of manganese and the recognition of its neurotoxicity, 1837-1936. 38
28416395 2018
35
18F-FP-CIT dopamine transporter PET findings in cirrhotic patients with parkinsonism. 38
28259768 2018
36
Potential for stem cell treatment in manganism. 38
29032009 2018
37
Manganese in manganism, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease: A narrative review. 38
29133694 2017
38
Manganese, manganism and other neurodegenerative diseases: Is it a cause of concern? 38
29133695 2017
39
Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells. 38
28232070 2017
40
Repeated manganese administration produced abnormal expression of circadian clock genes in the hypothalamus and liver of rats. 38
28511934 2017
41
Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways. 38
28914791 2017
42
Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells. 38
28378122 2017
43
Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis. 38
28692648 2017
44
Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson's disease-associated genes. 38
27913844 2017
45
Subchronic, Low-Level Intraperitoneal Injections of Manganese (IV) Oxide and Manganese (II) Chloride Affect Rat Brain Neurochemistry. 38
28460583 2017
46
Sodium p-Aminosalicylic Acid Reverses Sub-Chronic Manganese-Induced Impairments of Spatial Learning and Memory Abilities in Rats, but Fails to Restore γ-Aminobutyric Acid Levels. 38
28394286 2017
47
Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research. 38
28183032 2017
48
Comprehensive investigation of aberrant microRNAs expression in cells culture model of MnCl2-induced neurodegenerative disease. 38
28302480 2017
49
UHPLC-Q-TOF/MS based plasma metabolomics reveals the metabolic perturbations by manganese exposure in rat models. 38
28133682 2017
50
Neuroprotective and Therapeutic Strategies for Manganese-Induced Neurotoxicity. 38
30854510 2017

Variations for Manganese Poisoning

Expression for Manganese Poisoning

Search GEO for disease gene expression data for Manganese Poisoning.

Pathways for Manganese Poisoning

GO Terms for Manganese Poisoning

Sources for Manganese Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....