MCID: MNG007
MIFTS: 29

Manganese Poisoning

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Manganese Poisoning

MalaCards integrated aliases for Manganese Poisoning:

Name: Manganese Poisoning 58 17
Manganese Intoxication 58
Manganism 58

Characteristics:

Orphanet epidemiological data:

58
manganese poisoning
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Manganese Poisoning

MalaCards based summary : Manganese Poisoning, also known as manganese intoxication, is related to hair whorl and suppressor of tumorigenicity 3. The drug Manganese has been mentioned in the context of this disorder. Affiliated tissues include brain, liver and globus pallidus, and related phenotypes are hypertonia and gait disturbance

Wikipedia : 74 Manganism or manganese poisoning is a toxic condition resulting from chronic exposure to manganese. It... more...

Related Diseases for Manganese Poisoning

Diseases related to Manganese Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 hair whorl 10.3
2 suppressor of tumorigenicity 3 10.1
3 human immunodeficiency virus type 1 10.1
4 insulinoma 10.1
5 dystonia 10.1
6 tremor 10.1
7 chorea, childhood-onset, with psychomotor retardation 10.0
8 choreatic disease 10.0
9 amyotrophic lateral sclerosis 1 10.0
10 huntington disease 10.0
11 thyroid cancer, nonmedullary, 1 10.0
12 pancreatic cancer 10.0
13 aging 10.0
14 kufor-rakeb syndrome 10.0
15 coronary heart disease 1 10.0
16 hypermanganesemia with dystonia 1 10.0
17 fatty liver disease, nonalcoholic 1 10.0
18 pancreatic cancer 3 10.0
19 hypermanganesemia with dystonia 2 10.0
20 common cold 10.0
21 pica disease 10.0
22 diarrhea 10.0
23 lateral sclerosis 10.0
24 iron metabolism disease 10.0
25 agammaglobulinemia 10.0
26 bilirubin metabolic disorder 10.0
27 acute kidney failure 10.0
28 ischemia 10.0
29 central nervous system disease 10.0
30 movement disease 10.0
31 pneumonia 10.0
32 kidney disease 10.0
33 prion disease 10.0
34 b-cell lymphoma 10.0
35 polycythemia 10.0
36 rubella 10.0
37 dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease 10.0
38 autonomic dysfunction 10.0
39 myoclonus 10.0
40 thyroid carcinoma 10.0
41 ataxia and polyneuropathy, adult-onset 9.9
42 antisocial personality disorder 9.9
43 visual epilepsy 9.9
44 personality disorder 9.9
45 conversion disorder 9.9
46 substance abuse 9.9
47 liver disease 9.9
48 pancreatitis 9.9
49 learning disability 9.9
50 encephalopathy 9.9

Graphical network of the top 20 diseases related to Manganese Poisoning:



Diseases related to Manganese Poisoning

Symptoms & Phenotypes for Manganese Poisoning

Human phenotypes related to Manganese Poisoning:

58 31 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertonia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001276
2 gait disturbance 58 31 hallmark (90%) Very frequent (99-80%) HP:0001288
3 memory impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0002354
4 dystonia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001332
5 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
6 emotional lability 58 31 hallmark (90%) Very frequent (99-80%) HP:0000712
7 cogwheel rigidity 58 31 hallmark (90%) Very frequent (99-80%) HP:0002396
8 abnormality of mitochondrial metabolism 58 31 hallmark (90%) Very frequent (99-80%) HP:0003287
9 postural instability 58 31 hallmark (90%) Very frequent (99-80%) HP:0002172
10 bradykinesia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002067
11 postural tremor 58 31 hallmark (90%) Very frequent (99-80%) HP:0002174
12 abnormal globus pallidus morphology 58 31 hallmark (90%) Very frequent (99-80%) HP:0002453
13 sleep-wake cycle disturbance 58 31 hallmark (90%) Very frequent (99-80%) HP:0006979
14 increased reactive oxygen species production 58 31 hallmark (90%) Very frequent (99-80%) HP:0025464
15 visual impairment 58 31 frequent (33%) Frequent (79-30%) HP:0000505
16 obsessive-compulsive behavior 58 31 frequent (33%) Frequent (79-30%) HP:0000722
17 impotence 58 31 frequent (33%) Frequent (79-30%) HP:0000802
18 aggressive behavior 58 31 frequent (33%) Frequent (79-30%) HP:0000718
19 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
20 akinesia 58 31 frequent (33%) Frequent (79-30%) HP:0002304
21 inappropriate laughter 58 31 frequent (33%) Frequent (79-30%) HP:0000748
22 decreased female libido 58 31 frequent (33%) Frequent (79-30%) HP:0030018
23 decreased male libido 58 31 frequent (33%) Frequent (79-30%) HP:0040306
24 delusions 58 31 frequent (33%) Frequent (79-30%) HP:0000746
25 hallucinations 58 31 occasional (7.5%) Occasional (29-5%) HP:0000738
26 irritability 58 31 occasional (7.5%) Occasional (29-5%) HP:0000737
27 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
28 hypersexuality 58 31 occasional (7.5%) Occasional (29-5%) HP:0030214
29 abnormality of extrapyramidal motor function 58 Very frequent (99-80%)
30 impairment in personality functioning 58 Occasional (29-5%)

Drugs & Therapeutics for Manganese Poisoning

Drugs for Manganese Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Manganese Approved, Nutraceutical 7439-96-5 27854

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Determine the Effectiveness of Convective Uses of Basket Wires for the Maintenance of Stone and Pneumatic Probe in the Treatment of Ureteral Stones Completed NCT03980444

Search NIH Clinical Center for Manganese Poisoning

Genetic Tests for Manganese Poisoning

Anatomical Context for Manganese Poisoning

MalaCards organs/tissues related to Manganese Poisoning:

40
Brain, Liver, Globus Pallidus, Testes, Thyroid, Skin, Olfactory Bulb

Publications for Manganese Poisoning

Articles related to Manganese Poisoning:

(show top 50) (show all 520)
# Title Authors PMID Year
1
Mechanisms of Co, Ni, and Mn toxicity: From exposure and homeostasis to their interactions with and impact on lipids and biomembranes. 61
32126229 2020
2
The gut microbiota confers protection in the CNS against neurodegeneration induced by manganism. 61
32330797 2020
3
Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats. 61
32488470 2020
4
Mechanism of manganese dysregulation of dopamine neuronal activity. 61
32576620 2020
5
The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis. 61
32392784 2020
6
IRE1 signaling pathway mediates protective autophagic response against manganese-induced neuronal apoptosis in vivo and in vitro. 61
31931206 2020
7
Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism. 61
32003605 2020
8
The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity. 61
32001620 2020
9
Protective effects of trehalose against Mn-induced α-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy. 61
31497924 2020
10
Role for calcium signaling in manganese neurotoxicity. 61
31470248 2019
11
Effect of trehalose on manganese-induced mitochondrial dysfunction and neuronal cell damage in mice. 61
31483928 2019
12
Sodium Para-aminosalicylic Acid Reverses Changes of Glutamate Turnover in Manganese-Exposed Rats. 61
31838737 2019
13
Neuroprotective effects of docosahexaenoic acid against sub-acute manganese intoxication induced dopaminergic and motor disorders in mice. 61
31562917 2019
14
The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics. 61
30851309 2019
15
Role of Astrocytes in Manganese Neurotoxicity Revisited. 61
31571097 2019
16
Acute effects of methcathinone and manganese in mice: A dose response study. 61
31687570 2019
17
Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism. 61
30357569 2019
18
The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors. 61
30481588 2019
19
Mn-Induced Neurocytes Injury and Autophagy Dysfunction in Alpha-Synuclein Wild-Type and Knock-Out Mice: Highlighting the Role of Alpha-Synuclein. 61
30796692 2019
20
Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats. 61
31109603 2019
21
Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats. 61
31216744 2019
22
Manganism without Parkinsonism: Isolated Unilateral Upper Limb Tremor in a Welder. 61
30944287 2019
23
Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease. 61
30790043 2019
24
Overexpression of miR-138-5p suppresses MnCl2 -induced autophagy by targeting SIRT1 in SH-SY5Y cells. 61
30672645 2019
25
The neuroprotective properties of carnosine in a mouse model of manganism is mediated via mitochondria regulating and antioxidative mechanisms. 61
30856059 2019
26
Teaching NeuroImages: An imaging clue for treatable early childhood-onset dystonia: Manganism. 61
30718332 2019
27
Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation. 61
31293375 2019
28
LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. 61
30645642 2019
29
[Functional annotation of differentially expressed genes in manganese-poisoned rats and related metabolic pathways]. 61
30812084 2018
30
Exploration of the establishment of manganese poisoning rat model and analysis of discriminant methods. 61
30118795 2018
31
Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects. 61
30300793 2018
32
Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats. 61
30607343 2018
33
Manganese toxicity is targeting an early step in the dopamine signal transduction pathway that controls lateral cilia activity in the bivalve mollusc Crassostrea virginica. 61
30010023 2018
34
Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control. 61
30040983 2018
35
In vitro meningeal permeation of MnFe2O4 nanoparticles. 61
30053450 2018
36
Environmentally relevant manganese overexposure alters neural cell morphology and differentiation in vitro. 61
29486219 2018
37
Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. 61
29778792 2018
38
Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation. 61
29673961 2018
39
Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats. 61
29671021 2018
40
Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies. 61
29685658 2018
41
B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency. 61
29887684 2018
42
Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization. 61
29193611 2018
43
17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. 61
29183790 2018
44
Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy. 61
29408508 2018
45
[The comparison of neurobehavioral changes and impaired locations between the mouse model of manganism and Parkinson's disease]. 61
29699003 2018
46
The Impact of Environmental Mn Exposure on Insect Biology. 61
29545824 2018
47
Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. 61
28610743 2018
48
Sodium P-aminosalicylic acid inhibits sub-chronic manganese-induced neuroinflammation in rats by modulating MAPK and COX-2. 61
28651968 2018
49
The early history of manganese and the recognition of its neurotoxicity, 1837-1936. 61
28416395 2018
50
18F-FP-CIT dopamine transporter PET findings in cirrhotic patients with parkinsonism. 61
28259768 2018

Variations for Manganese Poisoning

Expression for Manganese Poisoning

Search GEO for disease gene expression data for Manganese Poisoning.

Pathways for Manganese Poisoning

GO Terms for Manganese Poisoning

Sources for Manganese Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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