MCID: MNS001
MIFTS: 39

Mansonelliasis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Mansonelliasis

MalaCards integrated aliases for Mansonelliasis:

Name: Mansonelliasis 12 73 20 58 44 15 17 70 32
Mansonella Perstans Infections 20 70
Mansonellosis 20 58

Characteristics:

Orphanet epidemiological data:

58
mansonelliasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1081
MeSH 44 D008368
NCIt 50 C84882
SNOMED-CT 67 240849009
ICD10 32 B74.4
ICD10 via Orphanet 33 B74.4
UMLS via Orphanet 71 C0024759
Orphanet 58 ORPHA2459
UMLS 70 C0024759 C0344031

Summaries for Mansonelliasis

Disease Ontology : 12 A filariasis that involves parasitic infection by the nematodes Mansonella ozzardi or Mansonella perstans, which reside in the skin or body cavities. The nematode is transmitted through the bite of midges and blackflies.

MalaCards based summary : Mansonelliasis, also known as mansonella perstans infections, is related to filariasis and loiasis. An important gene associated with Mansonelliasis is CCL13 (C-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Doxycycline and Antimalarials have been mentioned in the context of this disorder. Related phenotype is respiratory system.

Wikipedia : 73 Mansonelliasis is the condition of infection by the nematode Mansonella. The disease exists in Africa... more...

Related Diseases for Mansonelliasis

Diseases related to Mansonelliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 filariasis 30.2 IL5 IL10 IFNG
2 loiasis 30.1 IL5 IL10
3 exanthem 29.6 IL10 IFNG CXCL8
4 tungiasis 29.6 IL10 IFNG CXCL8
5 keratitis, hereditary 29.6 IL10 CXCL9 CXCL8
6 hypereosinophilic syndrome 29.4 IL5 IFNG CXCL8 CCL24 CCL17
7 leprosy 3 29.1 IL5 IL10 IFNG CXCL8 CXCL10
8 endotheliitis 10.3 CXCL9 CXCL10
9 opsoclonus-myoclonus syndrome 10.3 CXCL9 CXCL10
10 eosinophilic gastritis 10.3 IL5 CCL24
11 eosinophilic fasciitis 10.3 IL5 IFNG
12 oesophagostomiasis 10.2 MT-CYB DR1
13 palladium allergic contact dermatitis 10.2 IL10 CCL17
14 filarial elephantiasis 10.2
15 hydrocele 10.2
16 pemphigoid 10.2 IL5 IFNG
17 toxic oil syndrome 10.2 IL5 IFNG
18 disseminated eosinophilic collagen disease 10.2 IL5 CCL17
19 uveoparotid fever 10.2 IFNG CCL18
20 chromium allergic contact dermatitis 10.2 IL5 IL10
21 ceftriaxone allergy 10.2 IL5 IL10
22 atopic keratoconjunctivitis 10.2 IL5 IFNG CCL22
23 spotted fever rickettsiosis 10.1 IL10 IFNG
24 cow milk allergy 10.1 IL5 IL10
25 proliferative glomerulonephritis 10.1 IFNG CXCL9 CXCL10
26 mikulicz disease 10.1 IL5 IL10
27 chronic graft versus host disease 10.1 IL10 IFNG
28 pericardial tuberculosis 10.1 IL10 IFNG
29 vernal keratoconjunctivitis 10.1 IL5 CCL24
30 eosinophilic meningitis 10.1 IL5 IL10 CCL24
31 orofacial granulomatosis 10.1 IL10 IFNG
32 trichinosis 10.1 IL5 IL10
33 fuchs' heterochromic uveitis 10.1 IFNG CXCL8
34 giant papillary conjunctivitis 10.1 CXCL9 CXCL8 CCL24
35 papillary conjunctivitis 10.1 CXCL9 CXCL8 CCL24
36 eales disease 10.1 IL10 IFNG
37 basidiobolomycosis 10.0 MT-CYB IL10
38 cutaneous lupus erythematosus 10.0 IL10 IFNG CCL17
39 sarcoidosis 1 10.0 IFNG CXCL9 CXCL10 CCL18
40 extrapulmonary tuberculosis 10.0 IL10 IFNG CXCL9
41 acute transverse myelitis 10.0 IL10 CXCL8
42 melioidosis 10.0 IL10 IFNG CXCL9
43 leishmaniasis 10.0 IL5 IL10 IFNG
44 timothy grass allergy 10.0 IL5 IL10
45 acute cervicitis 10.0 IL10 CXCL8
46 acute gonococcal cervicitis 10.0 IL10 CXCL8
47 paragonimiasis 10.0 IL5 CCL17
48 nickel allergic contact dermatitis 10.0 IL5 IL10 IFNG
49 pulmonary eosinophilia 10.0 IL5 CXCL8 CCL17
50 plasmodium vivax malaria 10.0 IL10 IFNG CXCL10

Graphical network of the top 20 diseases related to Mansonelliasis:



Diseases related to Mansonelliasis

Symptoms & Phenotypes for Mansonelliasis

MGI Mouse Phenotypes related to Mansonelliasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.17 ATP7A CCL24 IFNG IGF2R IL10 IL5

Drugs & Therapeutics for Mansonelliasis

Drugs for Mansonelliasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
2 Antimalarials Phase 2
3 Antiparasitic Agents Phase 2
4 Antiprotozoal Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Anti-Infective Agents Phase 2
7
Albendazole Approved, Vet_approved 54965-21-8 2082
8
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
9 Tubulin Modulators
10 Anthelmintics
11 Antimitotic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Mansonella Perstans Infection in an Area Coendemic for Lymphatic Filariasis: A Pilot Study of the Effects of Doxycycline Completed NCT00340691 Phase 2 Doxycycline
2 Comparison of Early and Late Administration of Doxycycline in Their Efficacy Against Mansonella Perstans and in Development of Immunity Against Mycobacterial Infections Completed NCT02281643 Phase 2 Doxycycline
3 Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280 ivermectin and albendazole
4 Host Response to Infection and Treatment in the Filarial Diseases of Humans Recruiting NCT00001230

Search NIH Clinical Center for Mansonelliasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ivermectin

Cochrane evidence based reviews: mansonelliasis

Genetic Tests for Mansonelliasis

Anatomical Context for Mansonelliasis

Publications for Mansonelliasis

Articles related to Mansonelliasis:

(show top 50) (show all 73)
# Title Authors PMID Year
1
Preliminary comparison between an in-house real-time PCR vs microscopy for the diagnosis of Loa loa and Mansonella perstans. 61
33484727 2021
2
Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model. 61
33547508 2021
3
Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira. 61
31995172 2020
4
In vitro maintenance of Mansonella perstans microfilariae and its relevance for drug screening. 61
31580876 2019
5
In Silico Identification of Novel Biomarkers and Development of New Rapid Diagnostic Tests for the Filarial Parasites Mansonella perstans and Mansonella ozzardi. 61
31311985 2019
6
Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patent Mansonella perstans filariasis. 61
30561772 2019
7
Mansonellosis, the most neglected human filariasis. 61
30402239 2018
8
Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo. 61
29774301 2018
9
Immune response in Mansonella ozzardi infection modulated by IL-6/IL-10 axis in Amazon region of Brazil. 61
29032984 2018
10
Sensitivity of diagnostic methods for Mansonella ozzardi microfilariae detection in the Brazilian Amazon Region. 61
29412356 2018
11
Phase III Clinical Trial to Evaluate Ivermectin in the Reduction of Mansonella ozzardi infection in the Brazilian Amazon. 61
29313486 2018
12
Mansonellosis: current perspectives. 61
30050351 2018
13
[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax]. 61
30763500 2018
14
Epidemiology of Mansonella perstans in the middle belt of Ghana. 61
28061905 2017
15
Pulmonary localization of Mansonella perstans in a 16 months-old male patient in a tertiary care hospital in Bukavu, Democratic Republic of Congo. 61
28053918 2016
16
Atypical Mansonella ozzardi Microfilariae from an Endemic Area of Brazilian Amazonia. 61
27402517 2016
17
Update on the distribution of Mansonella perstans in the southern part of Cameroon: influence of ecological factors and mass drug administration with ivermectin. 61
27245442 2016
18
Mansonella ozzardi: a neglected New World filarial nematode. 61
27376501 2016
19
Mansonella ozzardi in Neotropical region of Argentina: Prevalence through time (1986-2010). 61
26433075 2016
20
Ceratopogonidae (Diptera: Nematocera) of the piedmont of the Yungas forests of Tucumán: ecology and distribution. 61
27896023 2016
21
Cross-Reactivity of Filariais ICT Cards in Areas of Contrasting Endemicity of Loa loa and Mansonella perstans in Cameroon: Implications for Shrinking of the Lymphatic Filariasis Map in the Central African Region. 61
26544042 2015
22
Vector-borne diseases in Haiti: a review. 61
25765486 2015
23
Filariasis in sub-Saharan immigrants attended in a health area of southern Spain: clinical and epidemiological findings. 61
23881533 2015
24
The occurrence of Mansonella perstans among residents of Calabar metropolis in Cross River State of Nigeria. 61
25911033 2015
25
Mansonella, including a Potential New Species, as Common Parasites in Children in Gabon. 61
26484866 2015
26
Molecular evidence of Wolbachia endosymbiosis in Mansonella perstans in Gabon, Central Africa. 61
24903665 2014
27
Mansonelliasis, a neglected parasitic disease in Haiti. 61
25317697 2014
28
Mansonella ozzardi in the municipality of Tefé, Amazonas, Brazil, 60 years after the first report: an epidemiologic study. 61
24863971 2014
29
Sustained clearance of Mansonella ozzardi infection after treatment with ivermectin in the Brazilian Amazon. 61
24710613 2014
30
Mansonella ozzardi (Nematoda: Onchocercidae) in the riverine population of the Tefé River, State of Amazonia, Brazil. 61
24553803 2014
31
Nodding syndrome in Mundri county, South Sudan: environmental, nutritional and infectious factors. 61
24235915 2013
32
[Mansonelliasis identified by a cervicovaginal smear at the university hospital center of Bobo-Dioulasso (Burkina Faso)]. 61
23392727 2012
33
[Contribution of the PCR assay to the diagnosis of Mansonella ozzardi in endemic areas of Argentina]. 61
22997768 2012
34
Investigation of the occurrence of Mansonella ozzardi in the State of Rondônia, Western Amazonia, Brazil. 61
21877064 2011
35
Improvement of a PCR test to diagnose infection by Mansonella ozzardi. 61
21779677 2011
36
Endemic mansonellosis in Emohua local government area, Nigeria: human parasitaemia and Culicoides biting patterns. 61
21406736 2011
37
Evolution, epidemiology, and population genetics of black flies (Diptera: Simuliidae). 61
20624485 2010
38
A Systematic Review of the Epidemiology of Mansonelliasis. 61
23878696 2010
39
[Ocular manifestations in mansonelliasis]. 61
18516413 2008
40
Prevalence of Mansonella perstans infections among the nomadic Fulanis of northern Nigeria. 61
16028864 2005
41
No evidence of Wolbachia endosymbiosis with Loa loa and Mansonella perstans. 61
12748849 2003
42
Epidemiology of concomitant infections due to Loa loa, Mansonella perstans, and Onchocerca volvulus in rain forest villages of Cameroon. 61
12592559 2003
43
Serum immunoglobulin G4 antibodies to the recombinant antigen, Ll-SXP-1, are highly specific for Loa loa infection. 61
12508156 2003
44
Use of the recombinant Onchocerca volvulus protein Ov20/OvS1 for the immunodiagnostic differentiation between onchocerciasis and mansonelliasis and for the characterization of hyperreactive onchocerciasis (sowda). 61
11169279 2000
45
First report of presumed parasitic keratitis in Indians from the Brazilian Amazon. 61
11095056 2000
46
Ivermectin treatment of mansonellosis in Trinidad. 61
10639847 1999
47
Induction of histamine release in parasitized individuals by somatic and cuticular antigens from Onchocerca volvulus. 61
10403330 1999
48
Single dose of ivermectin to control mansonellosis in Trinidad: a four-years follow-up study. 61
9861384 1998
49
The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection. 61
9176114 1997
50
Ivermectin treatment of mansonellosis in Blanchisseuse, Trinidad, West Indies. 61
9039278 1996

Variations for Mansonelliasis

Expression for Mansonelliasis

Search GEO for disease gene expression data for Mansonelliasis.

Pathways for Mansonelliasis

Pathways related to Mansonelliasis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 TCF15 IL5 IL10 IGF2R CXCL9 CXCL8
2
Show member pathways
13.51 IL5 IL10 IFNG CXCL9 CXCL8 CXCL10
3
Show member pathways
13.41 TCF15 IL5 IL10 IFNG CXCL8 CCL24
4
Show member pathways
13.28 CXCL9 CXCL8 CXCL10 CCL24 CCL22 CCL18
5
Show member pathways
13.25 IL5 IL10 CXCL9 CXCL8 CXCL10 CCL24
6
Show member pathways
12.84 TCF15 MAPRE2 IL5 IL10 IGF2R CXCL9
7
Show member pathways
12.73 IL5 IL10 IFNG CXCL9 CXCL8
8
Show member pathways
12.68 CXCL9 CXCL8 CXCL10 CCL24 CCL22 CCL18
9
Show member pathways
12.23 IL5 IFNG CXCL8 CXCL10 CCL17
10
Show member pathways
12.17 IL5 IL10 IGF2R IFNG CXCL8
11 11.86 IL5 IL10 IFNG
12 11.85 IL10 CXCL8 CCL22
13 11.8 IL10 IFNG CXCL8
14 11.69 IL5 IFNG CXCL8
15 11.68 IL5 IL10 IFNG
16
Show member pathways
11.64 IL5 IFNG CXCL8
17
Show member pathways
11.61 IL10 CXCL9 CXCL8 CXCL10 CCL24 CCL22
18 11.55 IL5 IL10 CCL17
19 11.45 IL10 CXCL8 CXCL10 CCL22
20 11.44 IL10 IFNG CXCL8
21 11.32 IL5 IL10 IFNG CCL22 CCL17
22 11.29 IFNG CXCL9 CXCL10
23 11.16 IL5 IL10 IFNG
24 11.1 IL5 IL10 IFNG
25 10.76 IL5 IL10 CXCL9 CXCL8 CXCL10 CCL24

GO Terms for Mansonelliasis

Cellular components related to Mansonelliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 IL5 IL10 IFNG CXCL9 CXCL8 CXCL10
2 extracellular space GO:0005615 9.4 IL5 IL10 IGF2R IFNG CXCL9 CXCL8
3 trans-Golgi network transport vesicle GO:0030140 9.16 IGF2R ATP7A

Biological processes related to Mansonelliasis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.25 IL5 IL10 IGF2R CXCL9 CXCL8 CXCL10
2 G protein-coupled receptor signaling pathway GO:0007186 10.16 IGF2R CXCL9 CXCL8 CXCL10 CCL24 CCL22
3 positive regulation of GTPase activity GO:0043547 10 MAPRE2 CCL24 CCL22 CCL18 CCL17 CCL13
4 cell-cell signaling GO:0007267 10 CXCL9 CXCL10 CCL24 CCL22 CCL18 CCL17
5 cytokine-mediated signaling pathway GO:0019221 9.97 IL5 IL10 CXCL8 CXCL10 CCL22
6 inflammatory response GO:0006954 9.97 IL5 CXCL9 CXCL8 CXCL10 CCL24 CCL22
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL24 CCL22 CCL18 CCL17 CCL13
8 cellular response to tumor necrosis factor GO:0071356 9.95 CXCL8 CCL24 CCL22 CCL18 CCL17 CCL13
9 immune response GO:0006955 9.9 IL5 IL10 IFNG CXCL9 CXCL8 CXCL10
10 cellular response to interferon-gamma GO:0071346 9.89 CCL24 CCL22 CCL18 CCL17 CCL13
11 cellular response to lipopolysaccharide GO:0071222 9.88 IL10 CXCL9 CXCL8 CXCL10
12 chemotaxis GO:0006935 9.86 CXCL9 CXCL8 CXCL10 CCL24 CCL22 CCL18
13 cellular response to interleukin-1 GO:0071347 9.85 CXCL8 CCL24 CCL22 CCL18 CCL17 CCL13
14 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.84 CXCL9 CXCL8 CXCL10 CCL13
15 monocyte chemotaxis GO:0002548 9.83 CCL24 CCL22 CCL18 CCL17 CCL13
16 lymphocyte chemotaxis GO:0048247 9.8 CCL24 CCL22 CCL18 CCL17 CCL13
17 response to virus GO:0009615 9.79 IFNG CXCL10 CCL22
18 eosinophil chemotaxis GO:0048245 9.62 CCL24 CCL13
19 response to copper ion GO:0046688 9.61 MT-CYB ATP7A
20 positive regulation of signaling receptor activity GO:2000273 9.6 IL10 IFNG
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IL10 IFNG
22 response to molecule of bacterial origin GO:0002237 9.58 IL10 CXCL8
23 neutrophil chemotaxis GO:0030593 9.56 CXCL9 CXCL8 CXCL10 CCL24 CCL22 CCL18
24 chemokine-mediated signaling pathway GO:0070098 9.23 CXCL9 CXCL8 CXCL10 CCL24 CCL22 CCL18

Molecular functions related to Mansonelliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.56 CXCL9 CXCL8 CXCL10 CCL24 CCL22 CCL18
2 CCR chemokine receptor binding GO:0048020 9.55 CCL24 CCL22 CCL18 CCL17 CCL13
3 CXCR chemokine receptor binding GO:0045236 9.43 CXCL9 CXCL8 CXCL10
4 cytokine activity GO:0005125 9.36 IL5 IL10 IFNG CXCL9 CXCL8 CXCL10
5 CXCR3 chemokine receptor binding GO:0048248 9.32 CXCL9 CXCL10

Sources for Mansonelliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....