MCID: MNS001
MIFTS: 23

Mansonelliasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Mansonelliasis

MalaCards integrated aliases for Mansonelliasis:

Name: Mansonelliasis 12 76 53 59 44 15 73
Mansonella Perstans Infections 53 73
Mansonellosis 53 59

Characteristics:

Orphanet epidemiological data:

59
mansonelliasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1081
ICD10 33 B74.4
MeSH 44 D008368
NCIt 50 C84882
SNOMED-CT 68 240849009
Orphanet 59 ORPHA2459
ICD10 via Orphanet 34 B74.4
UMLS via Orphanet 74 C0024759

Summaries for Mansonelliasis

Disease Ontology : 12 A filariasis that involves parasitic infection by the nematodes Mansonella ozzardi or Mansonella perstans, which reside in the skin or body cavities. The nematode is transmitted through the bite of midges and blackflies.

MalaCards based summary : Mansonelliasis, also known as mansonella perstans infections, is related to loiasis and onchocerciasis. An important gene associated with Mansonelliasis is HCCS (Holocytochrome C Synthase). The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Mansonelliasis (or mansonellosis) is the condition of infection by the nematode... more...

Related Diseases for Mansonelliasis

Diseases related to Mansonelliasis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 loiasis 10.0
2 onchocerciasis 9.9

Symptoms & Phenotypes for Mansonelliasis

GenomeRNAi Phenotypes related to Mansonelliasis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.92 KCMF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.92 HCCS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.92 HCCS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.92 KCMF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.92 KCMF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.92 KCMF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.92 KCMF1 HCCS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.92 KCMF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.92 HCCS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.92 KCMF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.92 KCMF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 HCCS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.92 KCMF1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.92 KCMF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.92 HCCS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.92 HCCS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.92 HCCS KCMF1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.92 KCMF1

Drugs & Therapeutics for Mansonelliasis

Drugs for Mansonelliasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
2 Anti-Bacterial Agents Phase 2
3 Anti-Infective Agents Phase 2,Not Applicable
4 Antimalarials Phase 2
5 Antiparasitic Agents Phase 2,Not Applicable
6 Antiprotozoal Agents Phase 2,Not Applicable
7
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
8
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
9
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
10
Suramin Approved, Investigational 145-63-1 5361
11 Anthelmintics Not Applicable
12 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2 Doxycycline
2 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2 Doxycycline
3 Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280 Not Applicable ivermectin and albendazole
4 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230

Search NIH Clinical Center for Mansonelliasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: mansonelliasis

Genetic Tests for Mansonelliasis

Anatomical Context for Mansonelliasis

MalaCards organs/tissues related to Mansonelliasis:

41
Skin

Publications for Mansonelliasis

Articles related to Mansonelliasis:

# Title Authors Year
1
Mansonelliasis, a neglected parasitic disease in Haiti. ( 25317697 )
2014
2
A Systematic Review of the Epidemiology of Mansonelliasis. ( 23878696 )
2010
3
Use of the recombinant Onchocerca volvulus protein Ov20/OvS1 for the immunodiagnostic differentiation between onchocerciasis and mansonelliasis and for the characterization of hyperreactive onchocerciasis (sowda). ( 11169279 )
2000
4
Mansonelliasis in the ComisarA-a del Vaupes of Colombia. ( 5435931 )
1970

Variations for Mansonelliasis

Expression for Mansonelliasis

Search GEO for disease gene expression data for Mansonelliasis.

Pathways for Mansonelliasis

GO Terms for Mansonelliasis

Sources for Mansonelliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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