MCID: MRN001
MIFTS: 37

Marantic Endocarditis

Categories: Cardiovascular diseases, Blood diseases

Aliases & Classifications for Marantic Endocarditis

MalaCards integrated aliases for Marantic Endocarditis:

Name: Marantic Endocarditis 12 15
Non-Bacterial Thrombotic Endocarditis 12 73
Non-Infective Endocarditis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060068

Summaries for Marantic Endocarditis

Disease Ontology : 12 An endocarditis that results from the deposition of small sterile vegetations on valve leaflets.

MalaCards based summary : Marantic Endocarditis, also known as non-bacterial thrombotic endocarditis, is related to endocarditis and heparin-induced thrombocytopenia. An important gene associated with Marantic Endocarditis is PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include skin, thyroid and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Non-bacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile... more...

Related Diseases for Marantic Endocarditis

Diseases related to Marantic Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.3 F2 PLAT SERPINC1
2 heparin-induced thrombocytopenia 31.0 F3 SERPINC1
3 disseminated intravascular coagulation 28.4 F2 F3 PLAT SERPINC1 SERPINF2 THBD
4 pulmonary embolism 28.0 F2 F3 MTHFR PLAT SERPINC1 SERPINF2
5 stroke, ischemic 27.2 F2 F3 MTHFR PLAT SERPINC1 SERPINF2
6 cerebral falx meningioma 10.8 F2 F3
7 cerebral sinovenous thrombosis 10.8 F2 F3
8 qualitative platelet defect 10.8 F2 F3
9 von willebrand disease, type 1 10.8 F2 F3
10 prothrombin deficiency, congenital 10.8 F2 SERPINC1
11 femoral neuropathy 10.8 F2 F3
12 alcohol-related birth defect 10.8 F2 F3
13 hantavirus pulmonary syndrome 10.8 F2 F3
14 cavernous sinus thrombosis 10.8 PTCRA SERPINC1
15 anterior cranial fossa meningioma 10.8 F2 F3
16 ischemic colitis 10.8 F2 SERPINC1
17 anterior spinal artery syndrome 10.7 F2 SERPINC1
18 subendocardial myocardial infarction 10.7 F2 SERPINC1
19 splenic disease 10.7 F2 F3
20 sneddon syndrome 10.7 F2 SERPINC1
21 esophageal varix 10.7 F2 SERPINC1
22 cold urticaria 10.7 SERPINC1 SERPINF2
23 post-thrombotic syndrome 10.6 F2 SERPINC1
24 hemophilia 10.6 F2 F3
25 hypersplenism 10.6 F2 SERPINC1
26 factor xiii deficiency 10.6 F3 SERPINF2
27 endocardium disease 10.5 F2 F3
28 factor xii deficiency 10.5 F3 SERPINC1
29 fibrinolytic defect 10.5 PLAT SERPINC1
30 factor v deficiency 10.5 F2 F3 PTCRA
31 fournier gangrene 10.5 F2 F3 SERPINC1
32 leech infestation 10.5 F2 F3 SERPINC1
33 analbuminemia 10.5 F2 F3
34 sagittal sinus thrombosis 10.5 F2 F3 SERPINC1
35 blue toe syndrome 10.5 F2 F3 SERPINC1
36 inherited blood coagulation disease 10.5 F2 F3 SERPINC1
37 peripheral vertigo 10.5 F2 F3 SERPINC1
38 hemorrhagic fever 10.5 F2 F3 SERPINC1
39 argentine hemorrhagic fever 10.5 PLAT SERPINC1
40 hemophilia b 10.5 F2 F3 SERPINC1
41 hepatitis a 10.5 F2 F3 SERPINC1
42 factor x deficiency 10.5 F2 F3 SERPINC1
43 plasminogen activator inhibitor-1 deficiency 10.5 PLAT SERPINF2
44 shwartzman phenomenon 10.5 F3 THBD
45 pulmonary immaturity 10.5 F3 SERPINC1
46 thrombocytosis 10.5 F2 F3 SERPINC1
47 neonatal stroke 10.5 MTHFR PROC
48 blood platelet disease 10.5 F2 F3 SERPINC1
49 alpha-2-plasmin inhibitor deficiency 10.5 F2 SERPINC1 SERPINF2
50 immune system disease 10.5 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Marantic Endocarditis:



Diseases related to Marantic Endocarditis

Symptoms & Phenotypes for Marantic Endocarditis

MGI Mouse Phenotypes related to Marantic Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 PROC PTCRA CD5 SERPINC1 F2 THBD
2 homeostasis/metabolism MP:0005376 9.91 PROC SERPINC1 SERPINF2 F2 THBD F3
3 immune system MP:0005387 9.76 PROC PTCRA CD5 SERPINC1 F2 THBD
4 integument MP:0010771 9.43 PLAT CD5 F2 THBD F3 MTHFR
5 nervous system MP:0003631 9.23 PROC CD5 SERPINC1 F2 THBD F3

Drugs & Therapeutics for Marantic Endocarditis

Search Clinical Trials , NIH Clinical Center for Marantic Endocarditis

Genetic Tests for Marantic Endocarditis

Anatomical Context for Marantic Endocarditis

MalaCards organs/tissues related to Marantic Endocarditis:

41
Skin, Thyroid, Lung

Publications for Marantic Endocarditis

Articles related to Marantic Endocarditis:

(show all 50)
# Title Authors Year
1
Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study. ( 29980854 )
2018
2
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer. ( 29895577 )
2018
3
Marantic endocarditis and paraneoplastic pulmonary embolism. ( 28710195 )
2017
4
A large aortic valve vegetation: an unusual case of non-bacterial thrombotic (marantic) endocarditis. ( 28364443 )
2017
5
Non-bacterial thrombotic endocarditis in a Trousseau syndrome patient with stomach cancer: A case report. ( 27758062 )
2016
6
Correction of coagulopathy associated with non-bacterial thrombotic endocarditis (NBTE) by surgical debulking in a case of ovarian clear cell carcinoma. ( 27354993 )
2016
7
Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma. ( 27833758 )
2016
8
A classical case of non-bacterial thrombotic endocarditis from pancreatic adenocarcinoma presenting as multiple strokes, myocardial infarction and acute limb ischaemia. ( 28031849 )
2016
9
Recurrent cerebral infarcts secondary to marantic endocarditis in a patient with adenocarcinoma of the lung. ( 27663211 )
2016
10
Non-Bacterial Thrombotic Endocarditis of Aortic Valve due to Hypereosinophilic Syndrome. ( 28290180 )
2016
11
[Non-bacterial thrombotic endocarditis on the bicuspid aortic valve in a 25-year-old male with lupus anticoagulant]. ( 27088201 )
2016
12
Multiple cerebral artery occlusion due to non-bacterial thrombotic endocarditis: an autopsy case report. ( 26960272 )
2016
13
Right ventricular marantic endocarditis. ( 26693318 )
2015
14
Infected marantic endocarditis with leukemoid reaction. ( 24882548 )
2014
15
Marantic endocarditis presenting with multifocal neurological symptoms. ( 23402487 )
2013
16
Porcine models of non-bacterial thrombotic endocarditis (NBTE) and infective endocarditis (IE) caused by Staphylococcus aureus: a preliminary study. ( 24151763 )
2013
17
Mitral valve surgery for marantic endocarditis and multiple cerebral embolisation. ( 23253884 )
2013
18
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. ( 24341951 )
2013
19
Stroke, aortic vegetations and disseminated adenocarcinoma--a case of marantic endocarditis. ( 21885337 )
2012
20
Marantic endocarditis - A not so benign entity. ( 22847046 )
2012
21
Marantic endocarditis with cardioembolic strokes mimicking leptomeningeal metastases in breast cancer. ( 21788555 )
2011
22
Non-bacterial thrombotic endocarditis with systemic embolic events caused by adenomyosis. ( 21827568 )
2011
23
Marantic endocarditis and adenocarcinoma of unknown primary site. ( 21552651 )
2011
24
Nonbacterial thrombotic (marantic) endocarditis in a patient with colorectal cancer. ( 20838062 )
2010
25
Nonbacterial thrombotic (marantic) endocarditis. ( 20486525 )
2010
26
Nonbacterial thrombotic endocarditis (marantic endocarditis) in cancer patients. ( 20397972 )
2010
27
Acute coronary syndrome in a patient with acquired immunodeficiency syndrome and non-bacterial thrombotic endocarditis. ( 20034971 )
2010
28
Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series. ( 20651968 )
2009
29
Marantic endocarditis as an unusual paraneoplastic syndrome of head and neck squamous cell carcinoma. ( 19442361 )
2009
30
An unusual case of nonbacterial thrombotic (marantic) endocarditis. ( 19154931 )
2009
31
Marantic endocarditis presenting as recurrent arterial embolisation. ( 17996318 )
2009
32
Marantic endocarditis and disseminated intravascular coagulation with systemic emboli in presentation of pancreatic cancer. ( 18323562 )
2008
33
Quadrivalvular marantic endocarditis (ME) mimicking acute bacterial endocarditis (ABE). ( 17362797 )
2007
34
Marantic endocarditis (NBTE) with systemic emboli and paraneoplastic cerebellar degeneration: uncommon presentation of ovarian cancer. ( 17205388 )
2007
35
Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis. ( 17044380 )
2006
36
Synchronous primary endometrial and ovarian carcinoma in a patient with marantic endocarditis. ( 17018489 )
2006
37
Recurrent embolism in the course of marantic endocarditis. ( 15919332 )
2005
38
Primary antiphospholipid syndrome and factor V Leiden mutation in a young patient with non-bacterial thrombotic endocarditis and transient ischemic stroke. ( 16411415 )
2005
39
Coagulopathy, marantic endocarditis, and cerebrovascular accidents as paraneoplastic features in medullary thyroid cancer--case report and review of the literature. ( 12930605 )
2003
40
Some unusual complications of malignancies: case 2. Marantic endocarditis in advanced cancer. ( 12351608 )
2002
41
Non-bacterial thrombotic (marantic) endocarditis associated with giant-cell arteritis. ( 11557334 )
2001
42
Right-sided non-bacterial thrombotic endocarditis in a chronic hemodialysis patient with Muir-Torre syndrome. ( 11334322 )
2001
43
Cutaneous manifestations of marantic endocarditis. ( 10809980 )
2000
44
Images in Geriatric Cardiology - Acute Myelogenous Leukemia Presenting as Embolic Marantic Endocarditis. ( 11416412 )
1997
45
Bronchogenic carcinoma, leukemoid reaction, marantic endocarditis, and consumptive thrombocytopathy. ( 6889655 )
1982
46
Marantic endocarditis in children and young adults: clinical and pathological findings. ( 7303049 )
1981
47
Marantic endocarditis: diagnosis by 2-D echocardiography. ( 7249701 )
1981
48
Cerebral embolism, marantic endocarditis, and cancer. ( 1259640 )
1976
49
Clinicopathologic conference: Marantic endocarditis. ( 4831324 )
1974
50
Embolism from marantic endocarditis as a manifestation of occult carcinoma. ( 14426661 )
1960

Variations for Marantic Endocarditis

Expression for Marantic Endocarditis

Search GEO for disease gene expression data for Marantic Endocarditis.

Pathways for Marantic Endocarditis

Pathways related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 F2 F3 PLAT PROC SERPINC1 SERPINF2
2
Show member pathways
12.38 F2 F3 PROC SERPINC1 THBD
3
Show member pathways
11.94 F2 MTHFR PLAT
4
Show member pathways
11.83 F2 PROC THBD
5
Show member pathways
11.7 F2 F3 PLAT PROC SERPINC1 SERPINF2
6 11.31 F2 F3 PLAT PROC SERPINC1 SERPINF2
7 10.54 F2 PROC
8 10.44 PLAT SERPINF2

GO Terms for Marantic Endocarditis

Cellular components related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 F2 F3 PLAT PROC SERPINC1 SERPINF2
2 blood microparticle GO:0072562 9.33 F2 SERPINC1 SERPINF2
3 cell surface GO:0009986 9.02 F3 FOLH1 PLAT SERPINF2 THBD

Biological processes related to Marantic Endocarditis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.69 F2 PROC THBD
2 acute-phase response GO:0006953 9.52 F2 SERPINF2
3 positive regulation of collagen biosynthetic process GO:0032967 9.49 F2 SERPINF2
4 negative regulation of proteolysis GO:0045861 9.48 F2 PLAT
5 signal peptide processing GO:0006465 9.46 F2 PROC
6 negative regulation of blood coagulation GO:0030195 9.43 PROC THBD
7 fibrinolysis GO:0042730 9.43 F2 PLAT SERPINF2
8 blood coagulation GO:0007596 9.43 F2 F3 PLAT PROC SERPINC1 THBD
9 regulation of blood coagulation GO:0030193 9.4 F2 SERPINC1
10 peptidyl-glutamic acid carboxylation GO:0017187 9.37 F2 PROC
11 negative regulation of fibrinolysis GO:0051918 9.33 F2 SERPINF2 THBD
12 negative regulation of platelet activation GO:0010544 9.32 F2 THBD
13 hemostasis GO:0007599 9.02 F2 F3 PROC SERPINC1 THBD

Molecular functions related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.56 F2 FOLH1 PLAT PROC
2 serine-type peptidase activity GO:0008236 9.33 F2 PLAT PROC
3 protease binding GO:0002020 9.13 F3 SERPINC1 SERPINF2
4 serine-type endopeptidase activity GO:0004252 8.92 F2 F3 PLAT PROC

Sources for Marantic Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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