MCID: MRN001
MIFTS: 38

Marantic Endocarditis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Marantic Endocarditis

MalaCards integrated aliases for Marantic Endocarditis:

Name: Marantic Endocarditis 12 15
Non-Bacterial Thrombotic Endocarditis 12 71
Non-Infective Endocarditis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060068
UMLS 71 C0221390 C3202971

Summaries for Marantic Endocarditis

Disease Ontology : 12 An endocarditis that results from the deposition of small sterile vegetations on valve leaflets.

MalaCards based summary : Marantic Endocarditis, also known as non-bacterial thrombotic endocarditis, is related to heparin-induced thrombocytopenia and endocarditis. An important gene associated with Marantic Endocarditis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Heparin and Enoxaparin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Nonbacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile vegetations... more...

Related Diseases for Marantic Endocarditis

Diseases related to Marantic Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 heparin-induced thrombocytopenia 30.8 SERPINC1 F3
2 endocarditis 30.7 SERPINC1 PLAT F2 CRP APOH
3 infective endocarditis 30.7 F2 CRP APOH
4 inferior myocardial infarction 30.5 PLG PLAT
5 raynaud phenomenon 30.2 VWF APOH
6 aortic valve insufficiency 30.2 VWF CRP
7 sneddon syndrome 30.1 SERPINC1 F2 APOH
8 splenic infarction 29.5 SERPINC1 F3 F2 CRP APOH
9 vasculitis 29.3 VWF SELP CRP APOH
10 disseminated intravascular coagulation 29.0 VWF SERPINC1 PLG PLAT F3 F2
11 mitral valve stenosis 28.9 VWF SERPINC1 SELP F3 F2 CRP
12 intracranial embolism 28.8 SERPINC1 SELP PLG PLAT F3 F2
13 pulmonary embolism 28.6 VWF SERPINC1 PLAT F3 F2 CRP
14 thrombophilia 28.5 VWF SERPINC1 SELP PLAT F3 F2
15 acute myocardial infarction 28.3 VWF SERPINC1 SELP PLG PLAT F3
16 antiphospholipid syndrome 27.9 VWF SERPINC1 SELP PLAT F3 F2
17 thrombocytopenia 27.9 VWF SERPINC1 SELP PLAT F3 F2
18 stroke, ischemic 27.8 VWF SERPINC1 SELP PLG PLAT F3
19 thrombophlebitis 27.4 VWF SERPINC1 SELP PLG PLAT F3
20 femoral neuropathy 10.4 F3 F2
21 pancreatic cancer 10.4
22 adenocarcinoma 10.4
23 hemopneumothorax 10.4 F3 F2
24 gastric hemangioma 10.4 F3 F2
25 orbital osteomyelitis 10.4 F2 CRP
26 small intestine diverticulitis 10.4 F2 CRP
27 vulvar angiokeratoma 10.4 SERPINC1 F3
28 hematocele of tunica vaginalis testis 10.4 F2 CRP
29 intracranial hypotension 10.4 F3 F2
30 critical illness polyneuropathy 10.4 F3 CRP
31 fibrinolytic defect 10.3 SERPINC1 PLAT
32 ascending cholangitis 10.3 F2 CRP
33 splenic abscess 10.3 F2 CRP
34 acalculous cholecystitis 10.3 F2 CRP
35 aspiration pneumonitis 10.3 F3 CRP
36 ovarian clear cell carcinoma 10.3
37 acute hemorrhagic encephalitis 10.3 F3 F2
38 cardiogenic shock 10.3 PLAT CRP
39 kidney cortex necrosis 10.3 PLG F2
40 hantavirus pulmonary syndrome 10.3 F3 F2
41 paralytic ileus 10.3 F2 CRP
42 intracranial hypertension, idiopathic 10.3 F3 F2
43 pyuria 10.3 F2 CRP
44 ligneous conjunctivitis 10.3 PLG PLAT
45 anterior cerebral artery infarction 10.3 PLG PLAT
46 cardiac rupture 10.3 PLAT CRP
47 kwashiorkor 10.3 F2 CRP
48 klebsiella pneumonia 10.3 PLAT CRP
49 factor x deficiency 10.3 F3 F2
50 argentine hemorrhagic fever 10.3 SERPINC1 PLAT

Graphical network of the top 20 diseases related to Marantic Endocarditis:



Diseases related to Marantic Endocarditis

Symptoms & Phenotypes for Marantic Endocarditis

MGI Mouse Phenotypes related to Marantic Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CRP F2 F3 PLAT PLG SELP
2 homeostasis/metabolism MP:0005376 9.61 APOH CRP F2 F3 PLAT PLG
3 immune system MP:0005387 9.23 CRP F2 F3 PLAT PLG SELP

Drugs & Therapeutics for Marantic Endocarditis

Drugs for Marantic Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
2
Enoxaparin Approved Phase 3 9005-49-6 772
3
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
4
Dalteparin Approved Phase 3 9005-49-6
5 Fibrinolytic Agents Phase 3
6 Anticoagulants Phase 3
7 Heparin, Low-Molecular-Weight Phase 3
8 calcium heparin Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of (LMWH) in Prevention of Thromboembolic Complication After (TACE) in Hepatocellular Carcinoma. Not yet recruiting NCT02715492 Phase 3 LMWH

Search NIH Clinical Center for Marantic Endocarditis

Genetic Tests for Marantic Endocarditis

Anatomical Context for Marantic Endocarditis

MalaCards organs/tissues related to Marantic Endocarditis:

40
Lung, Heart, Bone Marrow, Bone, Colon, Breast, Liver

Publications for Marantic Endocarditis

Articles related to Marantic Endocarditis:

(show top 50) (show all 220)
# Title Authors PMID Year
1
Marantic Endocarditis in a Long-Standing Untreated Rheumatoid Arthritis Patient. 61
32558680 2020
2
Antiphospholipid syndrome and the relationship between laboratory assay positivity and prevalence of non-bacterial thrombotic endocarditis: A retrospective cohort study. 61
32180317 2020
3
Marantic endocarditis. 61
32139116 2020
4
Non-bacterial thrombotic endocarditis in the context of pulmonary adenocarcinoma: a case report. 61
32128491 2020
5
Cholangiocarcinoma Manifesting as Non-Bacterial Thrombotic Endocarditis in a Young Patient. 61
31987802 2020
6
Antiphospholipid syndrome: a case report with an unusual wide spectrum of clinical manifestations. 61
32257065 2019
7
Treatment of Libman-Sacks endocarditis by combination of warfarin and immunosuppressive therapy. 61
31802766 2019
8
Nonbacterial thrombotic endocarditis as the initial presentation of prostate cancer- a case report. 61
31740891 2019
9
Atypical marantic endocarditis. 61
31712241 2019
10
A silent assassin: marantic endocarditis. 61
31707897 2019
11
Cancer and Cerebrovascular Disease. 61
31440841 2019
12
Small vessel multi-organ vasculitis and marantic endocarditis complicating rheumatoid arthritis. 61
31070579 2019
13
[Cortical blindness as initial manifestation of nonbacterial thrombotic endocarditis]. 61
30694190 2019
14
Resolution of large aortic valve vegetations in antiphospholipid syndrome treated with therapeutic anticoagulation: a report of two cases and literature review. 61
30290716 2018
15
Unusual rapid progression of non-bacterial thrombotic endocarditis in a patient with bladder cancer despite undergoing intensification treatment with rivaroxaban for acute venous thromboembolism. 61
30203033 2018
16
[Non-infective endocarditis]. 61
29903680 2018
17
A case of pulmonary embolism and non bacterial thrombotic endocarditis after chemotherapy to pancreatic cancer. 61
32177552 2018
18
Marantic Endocarditis Associated With T-Cell Large Granular Lymphocytic Leukemia: First Report of Its Occurrence With a Lymphoproliferative Malignancy in Adults. 61
30222473 2018
19
Acute Subdural Hemorrhage Associated With Both Metastatic Adenocarcinoma of the Dura and Minor Head Trauma: A Case Report and Review of the Literature. 61
31240071 2018
20
Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study. 61
29980854 2018
21
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer. 61
29895577 2018
22
Severe Fatal Systemic Embolism Due to Non-Bacterial Thrombotic Endocarditis as the Initial Manifestation of Gastric Adenocarcinoma: Case Report. 61
30581998 2018
23
A case of tricuspid valve non-bacterial thrombotic endocarditis presenting as pulmonary embolism in a patient with antiphospholipid antibody syndrome. 61
29535097 2018
24
[Non-bacterial thrombotic endocarditis. Report of one case]. 61
29488578 2017
25
Stroke due to non-bacterial thrombotic endocarditis as initial presentation of breast invasive ductal carcinoma. 61
27683971 2017
26
Marantic endocarditis and paraneoplastic pulmonary embolism. 61
28710195 2017
27
A large aortic valve vegetation: an unusual case of non-bacterial thrombotic (marantic) endocarditis. 61
28364443 2017
28
Newly recognized cerebral infarctions on postmortem imaging: a report of three cases with systemic infectious disease. 61
28068928 2017
29
A first described case of cancer-associated non-bacterial thrombotic endocarditis in the era of direct oral anticoagulants. 61
27888769 2017
30
Non-bacterial thrombotic endocarditis in the right atrium caused by pectus excavatum. 61
27683009 2016
31
[Three Mitral Valve Operations in a Patient with Trousseau Syndrome and Nonbacterial Thrombotic Endocarditis Caused by Ovarian Cancer]. 61
27909274 2016
32
Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma. 61
27833758 2016
33
A classical case of non-bacterial thrombotic endocarditis from pancreatic adenocarcinoma presenting as multiple strokes, myocardial infarction and acute limb ischaemia. 61
28031849 2016
34
Non-Bacterial Thrombotic Endocarditis of Aortic Valve due to Hypereosinophilic Syndrome. 61
28290180 2016
35
Aortic valve replacement for Libman-Sacks endocarditis. 61
27702929 2016
36
An Uncommon Cause of Stroke: Non-bacterial Thrombotic Endocarditis. 61
27449112 2016
37
Non-bacterial thrombotic endocarditis in a Trousseau syndrome patient with stomach cancer: A case report. 61
27758062 2016
38
Nonbacterial Thrombotic Endocarditis: Pathogenesis, Diagnosis, and Management. 61
27501336 2016
39
Recurrent cerebral infarcts secondary to marantic endocarditis in a patient with adenocarcinoma of the lung. 61
27663211 2016
40
Correction of coagulopathy associated with non-bacterial thrombotic endocarditis (NBTE) by surgical debulking in a case of ovarian clear cell carcinoma. 61
27354993 2016
41
Non-Bacterial Thrombotic Endocarditis in a Patient with Rheumatoid Arthritis. 61
27275182 2016
42
Stroke and a valvular lesion in a patient with stage IV non-small cell lung cancer. 61
27247207 2016
43
[Non-bacterial thrombotic endocarditis on the bicuspid aortic valve in a 25-year-old male with lupus anticoagulant]. 61
27088201 2016
44
Cancer-related Stroke due to Mural Thrombus in the Extracranial Carotid Artery. 61
27250060 2016
45
Behind Recurrent Thromboembolic Events. 61
30755886 2016
46
[Multiple cerebral artery occlusion due to non-bacterial thrombotic endocarditis: an autopsy case report]. 61
26960272 2016
47
Non-bacterial thrombotic endocarditis and subclinical myopericarditis in a patient with advanced rectal cancer. 61
26459494 2015
48
Frequent Ischemic Stroke as First Manifestation of Occult Colon Cancer: A Rare Case. 61
26460069 2015
49
Diagnostic yield of echocardiography in cancer patients with ischemic stroke. 61
25851114 2015
50
Diagnosis of an aortic valvular lesion. Non-bacterial thrombotic endocarditis (NBTE). 61
25586154 2015

Variations for Marantic Endocarditis

Expression for Marantic Endocarditis

Search GEO for disease gene expression data for Marantic Endocarditis.

Pathways for Marantic Endocarditis

Pathways related to Marantic Endocarditis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 VWF SERPINC1 SELP PLG PLAT F3
2
Show member pathways
11.96 PLG PLAT F2 CRP
3
Show member pathways
11.9 SELP F2 CEACAM5
4 11.67 PLG F3 CEACAM5
5
Show member pathways
11.63 VWF SERPINC1 PLG PLAT F3 F2
6 11.26 VWF SERPINC1 PLG PLAT F3 F2
7 11.11 SELP PLG PLAT
8 10.99 PLG F2
9 10.82 PLG PLAT
10 10.76 PLG F2
11 10.48 PLG PLAT

GO Terms for Marantic Endocarditis

Cellular components related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 VWF SERPINC1 PLG PLAT F2 CEACAM5
2 extracellular space GO:0005615 9.76 SERPINC1 SELP PLG PLAT F3 F2
3 cell surface GO:0009986 9.65 PLG PLAT F3 CEACAM5 APOH
4 extracellular region GO:0005576 9.61 VWF SERPINC1 PLG PLAT F3 F2
5 blood microparticle GO:0072562 9.54 SERPINC1 PLG F2
6 collagen-containing extracellular matrix GO:0062023 9.17 VWF SERPINC1 PLG PLAT F3 F2

Biological processes related to Marantic Endocarditis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.71 VWF SELP PLG APOH
2 cellular protein metabolic process GO:0044267 9.7 SERPINC1 PLG F2
3 leukocyte migration GO:0050900 9.69 SELP F2 CEACAM5
4 fibrinolysis GO:0042730 9.54 PLG PLAT F2
5 blood coagulation, intrinsic pathway GO:0007597 9.5 VWF F2 APOH
6 negative regulation of proteolysis GO:0045861 9.49 PLAT F2
7 positive regulation of blood coagulation GO:0030194 9.48 F2 APOH
8 plasminogen activation GO:0031639 9.46 PLAT APOH
9 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.43 PLG PLAT
10 regulation of blood coagulation GO:0030193 9.43 SERPINC1 F2 APOH
11 blood coagulation GO:0007596 9.43 VWF SERPINC1 PLG PLAT F3 F2
12 negative regulation of fibrinolysis GO:0051918 9.33 PLG F2 APOH
13 hemostasis GO:0007599 9.02 VWF SERPINC1 PLG F3 F2

Molecular functions related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.06 VWF TMEM19 SERPINC1 SELP PLG PLAT
2 serine-type peptidase activity GO:0008236 9.43 PLG PLAT F2
3 lipopolysaccharide binding GO:0001530 9.37 SELP F2
4 protease binding GO:0002020 9.33 VWF SERPINC1 F3
5 serine-type endopeptidase activity GO:0004252 9.26 PLG PLAT F3 F2
6 heparin binding GO:0008201 8.92 SERPINC1 SELP F2 APOH

Sources for Marantic Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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