MCID: MRN001
MIFTS: 42

Marantic Endocarditis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Marantic Endocarditis

MalaCards integrated aliases for Marantic Endocarditis:

Name: Marantic Endocarditis 12 15
Non-Bacterial Thrombotic Endocarditis 12 73
Non-Infective Endocarditis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060068

Summaries for Marantic Endocarditis

Disease Ontology : 12 An endocarditis that results from the deposition of small sterile vegetations on valve leaflets.

MalaCards based summary : Marantic Endocarditis, also known as non-bacterial thrombotic endocarditis, is related to endocarditis and sneddon syndrome. An important gene associated with Marantic Endocarditis is PROC (Protein C, Inactivator Of Coagulation Factors Va And VIIIa), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include heart, lung and pancreas, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Non-bacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile... more...

Related Diseases for Marantic Endocarditis

Diseases related to Marantic Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.4 F2 PLAT SERPINC1
2 sneddon syndrome 30.4 F2 SERPINC1
3 heparin-induced thrombocytopenia 30.4 F3 SERPINC1
4 intracranial embolism 30.2 F2 PLAT SERPINC1 SERPINF2
5 acute myocardial infarction 30.0 F3 PLAT SERPINC1 SERPINF2
6 antiphospholipid syndrome 29.7 F2 F3 MTHFR PLAT SERPINC1 THBD
7 disseminated intravascular coagulation 29.6 F2 F3 PLAT SERPINC1 SERPINF2 THBD
8 myocardial infarction 29.5 F2 F3 MTHFR PLAT SERPINC1 SERPINF2
9 pulmonary embolism 29.5 F2 F3 MTHFR PLAT SERPINC1 SERPINF2
10 stroke, ischemic 29.3 F2 F3 MTHFR PLAT SERPINC1 SERPINF2
11 ovarian clear cell carcinoma 10.3
12 pancreatic cancer 10.3
13 adenocarcinoma 10.3
14 hemophilia 10.3 F2 F3
15 cerebral falx meningioma 10.3 F2 F3
16 prothrombin deficiency 10.3 F2 F3
17 cerebral sinovenous thrombosis 10.2 F2 F3
18 qualitative platelet defect 10.2 F2 F3
19 femoral neuropathy 10.2 F2 F3
20 alcohol-related birth defect 10.2 F2 F3
21 prothrombin deficiency, congenital 10.2 F2 SERPINC1
22 hantavirus pulmonary syndrome 10.2 F2 F3
23 cavernous sinus thrombosis 10.2 PTCRA SERPINC1
24 von willebrand disease, type 1 10.2 F2 F3
25 ischemic colitis 10.2 F2 SERPINC1
26 anterior cranial fossa meningioma 10.2 F2 F3
27 subendocardial myocardial infarction 10.2 F2 SERPINC1
28 vascular hemostatic disease 10.2 F2 F3
29 splenic disease 10.2 F2 F3
30 esophageal varix 10.2 F2 SERPINC1
31 anterior spinal artery syndrome 10.2 F2 SERPINC1
32 cold urticaria 10.2 SERPINC1 SERPINF2
33 post-thrombotic syndrome 10.2 F2 SERPINC1
34 hypersplenism 10.2 F2 SERPINC1
35 leukemia 10.2
36 factor xiii deficiency 10.2 F3 SERPINF2
37 endocardium disease 10.2 F2 F3
38 hemorrhagic fever 10.2 F2 F3 SERPINC1
39 factor xii deficiency 10.2 F3 SERPINC1
40 factor v deficiency 10.2 F2 F3 PTCRA
41 fibrinolytic defect 10.2 PLAT SERPINC1
42 leech infestation 10.2 F2 F3 SERPINC1
43 fournier gangrene 10.2 F2 F3 SERPINC1
44 sagittal sinus thrombosis 10.2 F2 F3 SERPINC1
45 blue toe syndrome 10.2 F2 F3 SERPINC1
46 peripheral vertigo 10.2 F2 F3 SERPINC1
47 inherited blood coagulation disease 10.1 F2 F3 SERPINC1
48 argentine hemorrhagic fever 10.1 PLAT SERPINC1
49 hemophilia b 10.1 F2 F3 SERPINC1
50 factor x deficiency 10.1 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Marantic Endocarditis:



Diseases related to Marantic Endocarditis

Symptoms & Phenotypes for Marantic Endocarditis

MGI Mouse Phenotypes related to Marantic Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 CD5 F2 F3 PLAT PROC PTCRA
2 homeostasis/metabolism MP:0005376 9.91 F2 F3 MTHFR NAAA PLAT PROC
3 immune system MP:0005387 9.76 CD5 F2 F3 PLAT PROC PTCRA
4 integument MP:0010771 9.43 CD5 F2 F3 MTHFR PLAT THBD
5 nervous system MP:0003631 9.23 CD5 F2 F3 MTHFR PLAT PROC

Drugs & Therapeutics for Marantic Endocarditis

Search Clinical Trials , NIH Clinical Center for Marantic Endocarditis

Genetic Tests for Marantic Endocarditis

Anatomical Context for Marantic Endocarditis

MalaCards organs/tissues related to Marantic Endocarditis:

41
Heart, Lung, Pancreas, Thyroid, Liver, Spinal Cord, Placenta

Publications for Marantic Endocarditis

Articles related to Marantic Endocarditis:

(show top 50) (show all 94)
# Title Authors Year
1
Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study. ( 29980854 )
2018
2
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer. ( 29895577 )
2018
3
Unusual rapid progression of non-bacterial thrombotic endocarditis in a patient with bladder cancer despite undergoing intensification treatment with rivaroxaban for acute venous thromboembolism. ( 30203033 )
2018
4
Marantic Endocarditis Associated With T-Cell Large Granular Lymphocytic Leukemia: First Report of Its Occurrence With a Lymphoproliferative Malignancy in Adults. ( 30222473 )
2018
5
A case of tricuspid valve non-bacterial thrombotic endocarditis presenting as pulmonary embolism in a patient with antiphospholipid antibody syndrome. ( 29535097 )
2018
6
Marantic endocarditis and paraneoplastic pulmonary embolism. ( 28710195 )
2017
7
A large aortic valve vegetation: an unusual case of non-bacterial thrombotic (marantic) endocarditis. ( 28364443 )
2017
8
Stroke due to non-bacterial thrombotic endocarditis as initial presentation of breast invasive ductal carcinoma. ( 27683971 )
2017
9
A first described case of cancer-associated non-bacterial thrombotic endocarditis in the era of direct oral anticoagulants. ( 27888769 )
2017
10
Non-bacterial thrombotic endocarditis in a Trousseau syndrome patient with stomach cancer: A case report. ( 27758062 )
2016
11
Correction of coagulopathy associated with non-bacterial thrombotic endocarditis (NBTE) by surgical debulking in a case of ovarian clear cell carcinoma. ( 27354993 )
2016
12
Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma. ( 27833758 )
2016
13
A classical case of non-bacterial thrombotic endocarditis from pancreatic adenocarcinoma presenting as multiple strokes, myocardial infarction and acute limb ischaemia. ( 28031849 )
2016
14
Recurrent cerebral infarcts secondary to marantic endocarditis in a patient with adenocarcinoma of the lung. ( 27663211 )
2016
15
Non-Bacterial Thrombotic Endocarditis of Aortic Valve due to Hypereosinophilic Syndrome. ( 28290180 )
2016
16
[Non-bacterial thrombotic endocarditis on the bicuspid aortic valve in a 25-year-old male with lupus anticoagulant]. ( 27088201 )
2016
17
Non-bacterial thrombotic endocarditis in the right atrium caused by pectus excavatum. ( 27683009 )
2016
18
Non-Bacterial Thrombotic Endocarditis in a Patient with Rheumatoid Arthritis. ( 27275182 )
2016
19
An Uncommon Cause of Stroke: Non-bacterial Thrombotic Endocarditis. ( 27449112 )
2016
20
Right ventricular marantic endocarditis. ( 26693318 )
2015
21
Diagnosis of an aortic valvular lesion. Non-bacterial thrombotic endocarditis (NBTE). ( 25586154 )
2015
22
Non-bacterial thrombotic endocarditis and subclinical myopericarditis in a patient with advanced rectal cancer. ( 26459494 )
2015
23
Infected marantic endocarditis with leukemoid reaction. ( 24882548 )
2014
24
Marantic endocarditis presenting with multifocal neurological symptoms. ( 23402487 )
2013
25
Porcine models of non-bacterial thrombotic endocarditis (NBTE) and infective endocarditis (IE) caused by Staphylococcus aureus: a preliminary study. ( 24151763 )
2013
26
Mitral valve surgery for marantic endocarditis and multiple cerebral embolisation. ( 23253884 )
2013
27
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. ( 24341951 )
2013
28
Stroke, aortic vegetations and disseminated adenocarcinoma--a case of marantic endocarditis. ( 21885337 )
2012
29
Marantic endocarditis - A not so benign entity. ( 22847046 )
2012
30
Non-bacterial thrombotic endocarditis associated with Trousseau's syndrome. ( 27278214 )
2012
31
Marantic endocarditis with cardioembolic strokes mimicking leptomeningeal metastases in breast cancer. ( 21788555 )
2011
32
Non-bacterial thrombotic endocarditis with systemic embolic events caused by adenomyosis. ( 21827568 )
2011
33
Marantic endocarditis and adenocarcinoma of unknown primary site. ( 21552651 )
2011
34
Ovarian Clear Cell Carcinoma Presenting as Non-bacterial Thrombotic Endocarditis and Systemic Embolization. ( 29147261 )
2011
35
Nonbacterial thrombotic (marantic) endocarditis in a patient with colorectal cancer. ( 20838062 )
2010
36
Nonbacterial thrombotic (marantic) endocarditis. ( 20486525 )
2010
37
Nonbacterial thrombotic endocarditis (marantic endocarditis) in cancer patients. ( 20397972 )
2010
38
Acute coronary syndrome in a patient with acquired immunodeficiency syndrome and non-bacterial thrombotic endocarditis. ( 20034971 )
2010
39
Psychosis due to non-bacterial thrombotic endocarditis. ( 20056999 )
2010
40
Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series. ( 20651968 )
2009
41
Marantic endocarditis as an unusual paraneoplastic syndrome of head and neck squamous cell carcinoma. ( 19442361 )
2009
42
An unusual case of nonbacterial thrombotic (marantic) endocarditis. ( 19154931 )
2009
43
Marantic endocarditis presenting as recurrent arterial embolisation. ( 17996318 )
2009
44
The valvulopathy of non-bacterial thrombotic endocarditis. ( 19455890 )
2009
45
Non-bacterial thrombotic endocarditis in metastatic caecal adenocarcinoma. ( 19949478 )
2009
46
Marantic endocarditis and disseminated intravascular coagulation with systemic emboli in presentation of pancreatic cancer. ( 18323562 )
2008
47
Quadrivalvular marantic endocarditis (ME) mimicking acute bacterial endocarditis (ABE). ( 17362797 )
2007
48
Marantic endocarditis (NBTE) with systemic emboli and paraneoplastic cerebellar degeneration: uncommon presentation of ovarian cancer. ( 17205388 )
2007
49
Non-bacterial thrombotic endocarditis in an adult 14 months after cryopreserved aortic allograft valve implantation. ( 17702367 )
2007
50
Non-bacterial thrombotic endocarditis. ( 17881239 )
2007

Variations for Marantic Endocarditis

Expression for Marantic Endocarditis

Search GEO for disease gene expression data for Marantic Endocarditis.

Pathways for Marantic Endocarditis

Pathways related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 F2 F3 PLAT PROC SERPINC1 SERPINF2
2
Show member pathways
12.38 F2 F3 PROC SERPINC1 THBD
3
Show member pathways
11.94 F2 MTHFR PLAT
4
Show member pathways
11.83 F2 PROC THBD
5
Show member pathways
11.7 F2 F3 PLAT PROC SERPINC1 SERPINF2
6 11.31 F2 F3 PLAT PROC SERPINC1 SERPINF2
7 10.54 F2 PROC
8 10.44 PLAT SERPINF2

GO Terms for Marantic Endocarditis

Cellular components related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 F2 F3 PLAT PROC SERPINC1 SERPINF2
2 blood microparticle GO:0072562 9.43 F2 SERPINC1 SERPINF2
3 collagen-containing extracellular matrix GO:0062023 9.26 F3 PLAT SERPINC1 SERPINF2
4 cell surface GO:0009986 9.02 F3 FOLH1 PLAT SERPINF2 THBD

Biological processes related to Marantic Endocarditis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.67 F2 PROC SERPINC1
2 acute-phase response GO:0006953 9.48 F2 SERPINF2
3 negative regulation of proteolysis GO:0045861 9.46 F2 PLAT
4 positive regulation of collagen biosynthetic process GO:0032967 9.43 F2 SERPINF2
5 fibrinolysis GO:0042730 9.43 F2 PLAT SERPINF2
6 blood coagulation GO:0007596 9.43 F2 F3 PLAT PROC SERPINC1 THBD
7 negative regulation of blood coagulation GO:0030195 9.4 PROC THBD
8 regulation of blood coagulation GO:0030193 9.37 F2 SERPINC1
9 negative regulation of fibrinolysis GO:0051918 9.33 F2 SERPINF2 THBD
10 negative regulation of platelet activation GO:0010544 9.32 F2 THBD
11 hemostasis GO:0007599 9.02 F2 F3 PROC SERPINC1 THBD

Molecular functions related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.56 F2 FOLH1 PLAT PROC
2 serine-type peptidase activity GO:0008236 9.33 F2 PLAT PROC
3 protease binding GO:0002020 9.13 F3 SERPINC1 SERPINF2
4 serine-type endopeptidase activity GO:0004252 8.92 F2 F3 PLAT PROC

Sources for Marantic Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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