MCID: MRN001
MIFTS: 38

Marantic Endocarditis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Marantic Endocarditis

MalaCards integrated aliases for Marantic Endocarditis:

Name: Marantic Endocarditis 12 15
Non-Bacterial Thrombotic Endocarditis 12 71
Non-Infective Endocarditis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060068
UMLS 71 C0221390 C3202971

Summaries for Marantic Endocarditis

Disease Ontology : 12 An endocarditis that results from the deposition of small sterile vegetations on valve leaflets.

MalaCards based summary : Marantic Endocarditis, also known as non-bacterial thrombotic endocarditis, is related to endocarditis and heparin-induced thrombocytopenia. An important gene associated with Marantic Endocarditis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Non-bacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile... more...

Related Diseases for Marantic Endocarditis

Diseases related to Marantic Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.2 SERPINC1 PLAT F2 CRP
2 heparin-induced thrombocytopenia 30.8 SERPINC1 F3
3 sneddon syndrome 30.6 SERPINC1 F2
4 aortic valve insufficiency 30.4 VWF CRP
5 inferior myocardial infarction 30.3 PLG PLAT
6 splenic infarction 30.1 SERPINC1 F3 F2 CRP
7 mitral valve stenosis 29.6 VWF SERPINC1 F3 F2 CRP
8 intracranial embolism 29.3 SERPINC1 PLG PLAT F3 F2 CRP
9 cerebrovascular disease 29.3 VWF PLAT MTHFR F2 CRP
10 thrombocytopenia 29.1 VWF SERPINC1 PLAT F3 F2 CRP
11 acute myocardial infarction 28.9 VWF SERPINC1 PLG PLAT F3 CRP
12 disseminated intravascular coagulation 28.8 VWF SERPINC1 PLG PLAT F3 F2
13 thrombophilia 28.5 VWF SERPINC1 PLG PLAT MTHFR F3
14 antiphospholipid syndrome 28.4 VWF SERPINC1 PLAT MTHFR F3 F2
15 pulmonary embolism 28.4 VWF SERPINC1 PLAT MTHFR F3 F2
16 stroke, ischemic 28.2 VWF SERPINC1 PLG PLAT MTHFR F3
17 thrombophlebitis 27.9 VWF SERPINC1 PLG PLAT MTHFR F3
18 vulvar angiokeratoma 10.4 SERPINC1 F3
19 gastric hemangioma 10.4 F3 F2
20 femoral neuropathy 10.4 F3 F2
21 pancreatic cancer 10.4
22 infective endocarditis 10.4
23 adenocarcinoma 10.4
24 cardiac tuberculosis 10.4 SERPINC1 CRP
25 waterhouse-friderichsen syndrome 10.4 SERPINC1 F2
26 orbital osteomyelitis 10.4 F2 CRP
27 small intestine diverticulitis 10.4 F2 CRP
28 prothrombin deficiency, congenital 10.4 SERPINC1 F2
29 epidural abscess 10.4 F3 CRP
30 intracranial hypotension 10.4 F3 F2
31 thrombophlebitis migrans 10.4 SERPINC1 F3
32 aspiration pneumonitis 10.4 F3 CRP
33 necrotizing gastritis 10.4 F2 CRP
34 abducens nerve disease 10.4 SERPINC1 CRP
35 hepatic coma 10.4 SERPINC1 F2
36 splenic abscess 10.4 F2 CRP
37 ascending cholangitis 10.4 F2 CRP
38 acalculous cholecystitis 10.3 F2 CRP
39 hantavirus pulmonary syndrome 10.3 F3 F2
40 intracranial hypertension, idiopathic 10.3 F3 F2
41 mediastinitis 10.3 F2 CRP
42 acute cholangitis 10.3 F2 CRP
43 abdominal tuberculosis 10.3 F2 CRP
44 paralytic ileus 10.3 F2 CRP
45 fibrinolytic defect 10.3 SERPINC1 PLAT
46 ovarian clear cell carcinoma 10.3
47 common bile duct disease 10.3 F2 CRP
48 kwashiorkor 10.3 F2 CRP
49 hantavirus hemorrhagic fever with renal syndrome 10.3 F3 CRP
50 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 10.3 VWF CRP

Graphical network of the top 20 diseases related to Marantic Endocarditis:



Diseases related to Marantic Endocarditis

Symptoms & Phenotypes for Marantic Endocarditis

MGI Mouse Phenotypes related to Marantic Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 CRP F2 F3 JDP2 MTHFR PLAT
2 cardiovascular system MP:0005385 9.8 CRP F2 F3 PLAT PLG SERPINC1
3 immune system MP:0005387 9.56 CRP F2 F3 JDP2 PLAT PLG
4 integument MP:0010771 9.1 F2 F3 JDP2 MTHFR PLAT PLG

Drugs & Therapeutics for Marantic Endocarditis

Drugs for Marantic Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
2
Dalteparin Approved Phase 3 9005-49-6
3
Enoxaparin Approved Phase 3 9005-49-6 772
4 Estrogens Phase 3
5 Fibrinolytic Agents Phase 3
6 Anticoagulants Phase 3
7 Hormone Antagonists Phase 3
8 Heparin, Low-Molecular-Weight Phase 3
9 Antineoplastic Agents, Hormonal Phase 3
10 Hormones Phase 3
11 calcium heparin Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of (LMWH) in Prevention of Thromboembolic Complication After (TACE) in Hepatocellular Carcinoma. Not yet recruiting NCT02715492 Phase 3 LMWH

Search NIH Clinical Center for Marantic Endocarditis

Genetic Tests for Marantic Endocarditis

Anatomical Context for Marantic Endocarditis

MalaCards organs/tissues related to Marantic Endocarditis:

40
Heart, Lung, Kidney, Bone, Breast, Brain, Bone Marrow

Publications for Marantic Endocarditis

Articles related to Marantic Endocarditis:

(show top 50) (show all 214)
# Title Authors PMID Year
1
CHOLANGIOCARCINOMA MANIFESTING AS NON-BACTERIAL THROMBOTIC ENDOCARDITIS IN A YOUNG PATIENT. 61
31987802 2020
2
Treatment of Libman-Sacks endocarditis by combination of warfarin and immunosuppressive therapy. 61
31802766 2019
3
Nonbacterial thrombotic endocarditis as the initial presentation of prostate cancer- a case report. 61
31740891 2019
4
Atypical marantic endocarditis. 61
31712241 2019
5
A silent assassin: marantic endocarditis. 61
31707897 2019
6
Cancer and Cerebrovascular Disease. 61
31440841 2019
7
Small vessel multi-organ vasculitis and marantic endocarditis complicating rheumatoid arthritis. 61
31070579 2019
8
[Cortical blindness as initial manifestation of nonbacterial thrombotic endocarditis]. 61
30694190 2019
9
Resolution of large aortic valve vegetations in antiphospholipid syndrome treated with therapeutic anticoagulation: a report of two cases and literature review. 61
30290716 2018
10
Unusual rapid progression of non-bacterial thrombotic endocarditis in a patient with bladder cancer despite undergoing intensification treatment with rivaroxaban for acute venous thromboembolism. 61
30203033 2018
11
[Non-infective endocarditis]. 61
29903680 2018
12
Marantic Endocarditis Associated With T-Cell Large Granular Lymphocytic Leukemia: First Report of Its Occurrence With a Lymphoproliferative Malignancy in Adults. 61
30222473 2018
13
Acute Subdural Hemorrhage Associated With Both Metastatic Adenocarcinoma of the Dura and Minor Head Trauma: A Case Report and Review of the Literature. 61
31240071 2018
14
Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study. 61
29980854 2018
15
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer. 61
29895577 2018
16
Severe Fatal Systemic Embolism Due to Non-Bacterial Thrombotic Endocarditis as the Initial Manifestation of Gastric Adenocarcinoma: Case Report. 61
30581998 2018
17
A case of tricuspid valve non-bacterial thrombotic endocarditis presenting as pulmonary embolism in a patient with antiphospholipid antibody syndrome. 61
29535097 2018
18
[Non-bacterial thrombotic endocarditis. Report of one case]. 61
29488578 2017
19
Stroke due to non-bacterial thrombotic endocarditis as initial presentation of breast invasive ductal carcinoma. 61
27683971 2017
20
Marantic endocarditis and paraneoplastic pulmonary embolism. 61
28710195 2017
21
A large aortic valve vegetation: an unusual case of non-bacterial thrombotic (marantic) endocarditis. 61
28364443 2017
22
Newly recognized cerebral infarctions on postmortem imaging: a report of three cases with systemic infectious disease. 61
28068928 2017
23
A first described case of cancer-associated non-bacterial thrombotic endocarditis in the era of direct oral anticoagulants. 61
27888769 2017
24
[Three Mitral Valve Operations in a Patient with Trousseau Syndrome and Nonbacterial Thrombotic Endocarditis Caused by Ovarian Cancer]. 61
27909274 2016
25
Non-bacterial thrombotic endocarditis in the right atrium caused by pectus excavatum. 61
27683009 2016
26
Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma. 61
27833758 2016
27
A classical case of non-bacterial thrombotic endocarditis from pancreatic adenocarcinoma presenting as multiple strokes, myocardial infarction and acute limb ischaemia. 61
28031849 2016
28
Non-Bacterial Thrombotic Endocarditis of Aortic Valve due to Hypereosinophilic Syndrome. 61
28290180 2016
29
Non-bacterial thrombotic endocarditis in a Trousseau syndrome patient with stomach cancer: A case report. 61
27758062 2016
30
An Uncommon Cause of Stroke: Non-bacterial Thrombotic Endocarditis. 61
27449112 2016
31
Aortic valve replacement for Libman-Sacks endocarditis. 61
27702929 2016
32
Recurrent cerebral infarcts secondary to marantic endocarditis in a patient with adenocarcinoma of the lung. 61
27663211 2016
33
Nonbacterial Thrombotic Endocarditis: Pathogenesis, Diagnosis, and Management. 61
27501336 2016
34
Correction of coagulopathy associated with non-bacterial thrombotic endocarditis (NBTE) by surgical debulking in a case of ovarian clear cell carcinoma. 61
27354993 2016
35
Non-Bacterial Thrombotic Endocarditis in a Patient with Rheumatoid Arthritis. 61
27275182 2016
36
Stroke and a valvular lesion in a patient with stage IV non-small cell lung cancer. 61
27247207 2016
37
[Non-bacterial thrombotic endocarditis on the bicuspid aortic valve in a 25-year-old male with lupus anticoagulant]. 61
27088201 2016
38
Cancer-related Stroke due to Mural Thrombus in the Extracranial Carotid Artery. 61
27250060 2016
39
Behind Recurrent Thromboembolic Events. 61
30755886 2016
40
[Multiple cerebral artery occlusion due to non-bacterial thrombotic endocarditis: an autopsy case report]. 61
26960272 2016
41
Non-bacterial thrombotic endocarditis and subclinical myopericarditis in a patient with advanced rectal cancer. 61
26459494 2015
42
Frequent Ischemic Stroke as First Manifestation of Occult Colon Cancer: A Rare Case. 61
26460069 2015
43
Diagnostic yield of echocardiography in cancer patients with ischemic stroke. 61
25851114 2015
44
Diagnosis of an aortic valvular lesion. Non-bacterial thrombotic endocarditis (NBTE). 61
25586154 2015
45
Transcatheter aortic valve-in-valve implantation for severe bioprosthetic stenosis after Bentall operation using a homograft in a patient with Behçet's disease. 61
26204689 2015
46
Right ventricular marantic endocarditis. 61
26693318 2015
47
Update on blood culture-negative endocarditis. 61
25480453 2015
48
Cryptogenic subtype predicts reduced survival among cancer patients with ischemic stroke. 61
24994717 2014
49
Systemic inflammatory response and local cytokine expression in porcine models of endocarditis. 61
23879680 2014
50
Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis. 61
24341951 2014

Variations for Marantic Endocarditis

Expression for Marantic Endocarditis

Search GEO for disease gene expression data for Marantic Endocarditis.

Pathways for Marantic Endocarditis

GO Terms for Marantic Endocarditis

Cellular components related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 SERPINC1 PLG PLAT F3 F2 CRP
2 extracellular region GO:0005576 9.5 VWF SERPINC1 PLG PLAT F3 F2
3 blood microparticle GO:0072562 9.33 SERPINC1 PLG F2
4 collagen-containing extracellular matrix GO:0062023 9.1 VWF SERPINC1 PLG PLAT F3 F2

Biological processes related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.63 SERPINC1 PLG F2
2 negative regulation of proteolysis GO:0045861 9.43 PLAT F2
3 blood coagulation GO:0007596 9.43 VWF SERPINC1 PLG PLAT F3 F2
4 blood coagulation, intrinsic pathway GO:0007597 9.4 VWF F2
5 regulation of blood coagulation GO:0030193 9.37 SERPINC1 F2
6 fibrinolysis GO:0042730 9.33 PLG PLAT F2
7 negative regulation of fibrinolysis GO:0051918 9.32 PLG F2
8 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.26 PLG PLAT
9 hemostasis GO:0007599 9.02 VWF SERPINC1 PLG F3 F2

Molecular functions related to Marantic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 9.33 PLG PLAT F2
2 protease binding GO:0002020 9.13 VWF SERPINC1 F3
3 serine-type endopeptidase activity GO:0004252 8.92 PLG PLAT F3 F2

Sources for Marantic Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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