Aliases & Classifications for Marasmus

MalaCards integrated aliases for Marasmus:

Name: Marasmus 12 55 15 73
Nutritional Marasmus 12
Nutritional Atrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12328
ICD10 33 E41
ICD9CM 35 261
MeSH 44 D011502
UMLS 73 C0086588

Summaries for Marasmus

MalaCards based summary : Marasmus, also known as nutritional marasmus, is related to kwashiorkor and pure red-cell aplasia. An important gene associated with Marasmus is ALB (Albumin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Lamivudine and Nevirapine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and pancreas.

Wikipedia : 76 Marasmus is a form of severe malnutrition characterized by energy deficiency. It can occur in anyone... more...

Related Diseases for Marasmus

Diseases related to Marasmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 31.4 ALB SHBG TF TTR
2 pure red-cell aplasia 30.4 ALB TF
3 keratomalacia 30.2 TF TTR
4 shigellosis 29.1 CD79A TTR
5 anorexia nervosa 29.1 GH1 IGFBP3 TTR
6 protein-energy malnutrition 28.4 ALB CD79A TF TTR
7 aquagenic syringeal acrokeratoderm 10.9
8 fetal erythroblastosis 10.6 ALB SHBG
9 47, xxy 10.6 IGFBP3 SHBG
10 ariboflavinosis 10.5 ALB TF
11 complete androgen insensitivity syndrome 10.5 IGFBP3 SHBG
12 hypoadrenalism 10.5 GH1 SHBG
13 alcoholic liver cirrhosis 10.4 ALB TF
14 paramyloidosis 10.4 ALB TTR
15 pituitary adenoma 1, multiple types 10.3 GH1 IGFBP3
16 male reproductive organ cancer 10.3 IGFBP3 SHBG
17 gonadal disease 10.3 GH1 SHBG
18 hyperpituitarism 10.3 GH1 IGFBP3
19 burns 10.3 ALB TTR
20 chronic ulcer of skin 10.3 ALB TTR
21 isolated growth hormone deficiency, type ib 10.3 GH1 IGFBP3
22 decubitus ulcer 10.3 ALB TTR
23 hyperprolactinemia 10.3 GH1 SHBG
24 aleutian mink disease 10.3 ALB TTR
25 hyperthyroxinemia 10.3 ALB TTR
26 median rhomboid glossitis 10.3 TF TTR
27 wilson disease 10.3 ALB TF
28 autonomic nervous system disease 10.3 ALB TTR
29 laron syndrome 10.2 GH1 IGFBP3
30 uremia 10.2 ALB TF
31 demyelinating polyneuropathy 10.2 ALB TTR
32 retinitis pigmentosa 7 10.2 TF TTR
33 growth hormone deficiency 10.2 GH1 IGFBP3
34 breast disease 10.2 IGFBP3 SHBG
35 hypopituitarism 10.1 GH1 IGFBP3
36 cork-handlers' disease 10.1 ALB CD79A
37 ostertagiasis 10.1 ALB CD79A
38 dermatitis, atopic, 3 10.1 ALB CD79A
39 root caries 10.1 ALB CD79A
40 parotitis 10.1 ALB CD79A
41 orthostatic proteinuria 10.1 ALB CD79A
42 chronic graft versus host disease 10.1 ALB CD79A
43 diffuse glomerulonephritis 10.1 ALB CD79A
44 focal dermal hypoplasia 10.1 ALB CD79A
45 non-secretory myeloma 10.1 ALB CD79A
46 hypersensitivity reaction type iii disease 10.0 ALB CD79A
47 liver cirrhosis 10.0 ALB IGFBP3 TF
48 protein-losing enteropathy 10.0 ALB CD79A
49 ulcerative stomatitis 10.0 ALB CD79A
50 pneumocystosis 10.0 ALB CD79A

Comorbidity relations with Marasmus via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bronchitis Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Iron Deficiency Anemia Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Postinflammatory Pulmonary Fibrosis Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to Marasmus

Symptoms & Phenotypes for Marasmus

Drugs & Therapeutics for Marasmus

Drugs for Marasmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational 134678-17-4 60825
2
Nevirapine Approved 129618-40-2 4463
3
Zidovudine Approved 30516-87-1 35370
4
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
5
Cefdinir Approved Not Applicable 91832-40-5 6915944
6
Ethanol Approved Not Applicable 64-17-5 702
7 Anti-HIV Agents
8 Anti-Infective Agents ,Not Applicable
9 Antimetabolites ,Not Applicable
10 Antioxidants ,Not Applicable
11 Anti-Retroviral Agents
12 Antiviral Agents
13 Cytochrome P-450 CYP3A Inducers
14 Nucleic Acid Synthesis Inhibitors
15 Reverse Transcriptase Inhibitors
16 Anti-Bacterial Agents Not Applicable
17 Antibiotics, Antitubercular Not Applicable
18 Anticholesteremic Agents Not Applicable
19 Anti-Infective Agents, Local Not Applicable
20 Central Nervous System Depressants Not Applicable
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
22 Hypolipidemic Agents Not Applicable
23 Lipid Regulating Agents Not Applicable
24 Platelet Aggregation Inhibitors Not Applicable
25 policosanol Not Applicable
26 Disinfectants Not Applicable
27 alanine Nutraceutical Not Applicable
28 cysteine Nutraceutical Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Developmental Adaptation to an Obesogenic Environment Completed NCT02257593 Not Applicable
2 Safety and Metabolic Study of Highly Active Antiretroviral Therapy (HAART) in Malnourished Children With HIV Completed NCT01529125 zidovudine, lamivudine, nevirapine
3 Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition Completed NCT02053857 Not Applicable Amoxicillin
4 Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition Completed NCT01000298 Not Applicable Placebo;Amoxicillin;Cefdinir
5 Study of Antioxidants and Oxidants in Malnourished Children Completed NCT00069134 Not Applicable
6 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers Completed NCT01790815
7 Sixteen Years Trends in Reported Undernutrition in Switzerland Completed NCT03239093
8 Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition Completed NCT02413905
9 Effect of Policosanol as Monotherapy and Adjunctive to Statin Therapy Completed NCT00510809 Not Applicable Policosanol;Policosanol Plus Already In Use Statin Therapy
10 Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan) Active, not recruiting NCT02751476 Not Applicable
11 Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition Withdrawn NCT01395381 Not Applicable Placebo;Albendazole

Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

Anatomical Context for Marasmus

MalaCards organs/tissues related to Marasmus:

41
Liver, Testes, Pancreas, Adrenal Cortex, Small Intestine, Brain, Cortex

Publications for Marasmus

Articles related to Marasmus:

(show top 50) (show all 198)
# Title Authors Year
1
Genome sequence and description of <i>Clostridium niameyense</i> sp. nov., isolated from a human with marasmus in Nigeria. ( 29922472 )
2018
2
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. ( 24114907 )
2013
3
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. ( 22558267 )
2012
4
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic I^-cell dysfunction. ( 22386944 )
2012
5
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. ( 22072341 )
2011
6
Acute liver injury with severe coagulopathy in marasmus caused by a somatic delusional disorder. ( 25954537 )
2011
7
INCAP studies of kwashiorkor and marasmus. ( 20461902 )
2010
8
Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. ( 19116330 )
2009
9
The quality of the diet in Malawian children with kwashiorkor and marasmus. ( 16881921 )
2006
10
Lipid kinetic differences between children with kwashiorkor and those with marasmus. ( 16762938 )
2006
11
Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. ( 12081841 )
2002
12
Plasma fatty acids in children with grade III protein-energy malnutrition in its different clinical forms: marasmus, marasmic kwashiorkor, and kwashiorkor. ( 10341499 )
1999
13
Lipids, lipoproteins, and fatty acids during infantile marasmus in the FA"s area of Morocco. ( 10424250 )
1999
14
Ready-to-use therapeutic food for treatment of marasmus. ( 10347999 )
1999
15
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. ( 9625094 )
1998
16
Plasma concentration of taurine is higher in malnourished than control children: differences between kwashiorkor and marasmus. ( 9635065 )
1998
17
Protein-energy malnutrition (kwashiorkor and marasmus). ( 8699299 )
1996
18
Red blood cell antioxidant enzyme concentrations in kwashiorkor and marasmus. ( 7681643 )
1993
19
Risk factors for clinical marasmus: a case-control study of Bangladeshi children. ( 8505185 )
1993
20
Kwashiorkor and marasmus: evolution and distinguishing features. 1968. ( 1306670 )
1992
21
The exocrine pancreas in kwashiorkor and marasmus. Light and electron microscopy. ( 1523833 )
1992
22
Traditional perceptions of marasmus in Pakistan. ( 1901666 )
1991
23
Kwashiorkor-marasmus syndrome and nutritional rickets--a bone biopsy study. ( 1781011 )
1991
24
Kwashiorkor and marasmus: changing hospital incidence of syndromic presentation (1957-88). ( 2127923 )
1990
25
The long-term effects of early kwashiorkor compared with marasmus. IV. Performance on the national high school entrance examination. ( 2122403 )
1990
26
Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. ( 2115964 )
1990
27
Mild-moderate Kwashiorkor-Marasmus syndrome: anthropometric and biochemical observations. ( 2518626 )
1989
28
Peliosis hepatis in a patient with marasmus. ( 3135227 )
1988
29
Famine in Ethiopia 1983-1985: kwashiorkor and marasmus in four regions. ( 2438995 )
1987
30
Long-term effects of early kwashiorkor compared with marasmus. III. Fine motor skills. ( 3119813 )
1987
31
Long-term effects of early kwashiorkor compared with marasmus. I. Physical growth and sexual maturation. ( 3119811 )
1987
32
Screening for marasmus: a discriminant analysis as a guide to choose the anthropometric variables. ( 3101482 )
1987
33
Long-term effects of early kwashiorkor compared with marasmus. II. Intellectual performance. ( 3119812 )
1987
34
Severe undernutrition in Jamaica. Kwashiorkor and marasmus: the disease of the weanling. ( 3092564 )
1986
35
Protein-energy malnutrition (Kwashiorkor-Marasmus syndrome): terminology, classification and evolution. ( 3088855 )
1986
36
Marasmus. ( 3939295 )
1985
37
Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation. ( 3939688 )
1985
38
Marasmus--1985. ( 3932990 )
1985
39
Serum lipids in marasmus. ( 3934072 )
1985
40
Calcium metabolism in marasmus. ( 6442922 )
1984
41
Biochemical aspects of malabsorption in marasmus. ( 6418198 )
1984
42
Marasmus in a 17-month-old Laotian: impact of folk beliefs on health. ( 6420766 )
1984
43
Growth of Nigerian children with marasmus after hospital treatment. ( 6402601 )
1983
44
Controlled trial of copper supplementation during the recovery from marasmus. ( 6405607 )
1983
45
Gastric function in marasmus. ( 6427107 )
1983
46
Intestinal bypass in the rat: a model for growth failure, liver disease, and jejunal bacterial overgrowth in marasmus and kwashiorkor. ( 6821113 )
1982
47
Gastric mucosal functions and histology in marasmus. ( 6819226 )
1982
48
Urinary catecholamine in kwashiorkor and marasmus. ( 6819336 )
1982
49
Leucocyte protein and free alpha amino nitrogen levels in marasmus. ( 6796513 )
1981
50
Beetle marasmus. ( 6794839 )
1981

Variations for Marasmus

Expression for Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for Marasmus

Pathways related to Marasmus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 ALB TTR

GO Terms for Marasmus

Cellular components related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.63 ALB IGFBP3 SHBG SIAE TF TTR
2 endoplasmic reticulum lumen GO:0005788 9.43 ALB IGFBP3 TF
3 extracellular space GO:0005615 9.43 ALB GH1 IGFBP3 SIAE TF TTR
4 extracellular region GO:0005576 9.17 ALB GH1 IGFBP3 SHBG SIAE TF

Biological processes related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.43 ALB IGFBP3 TF
2 retina homeostasis GO:0001895 9.16 ALB TF
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 GH1 IGFBP3
4 cellular protein metabolic process GO:0044267 8.92 ALB IGFBP3 TF TTR

Sources for Marasmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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