Aliases & Classifications for Marasmus

MalaCards integrated aliases for Marasmus:

Name: Marasmus 12 54 15 17 70
Nutritional Marasmus 12 32
Nutritional Atrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12328
ICD9CM 34 261
MeSH 44 D011502
SNOMED-CT 67 154730001
ICD10 32 E41
UMLS 70 C0086588

Summaries for Marasmus

Disease Ontology : 12 A protein-energy malnutrition that is characterized by severe caloric deprivation, has symptom emaciation, decreased height and weight gain, and decreased metabolism with hypothermia, bradycardia, and constipation, and has material basis in severe caloric deprivation.

MalaCards based summary : Marasmus, also known as nutritional marasmus, is related to kwashiorkor and protein-energy malnutrition, and has symptoms including emaciation An important gene associated with Marasmus is ALB (Albumin), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Peptide hormone metabolism. The drugs Anti-Infective Agents and Disinfectants have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and thyroid.

Wikipedia : 73 Marasmus is a form of severe malnutrition characterized by energy deficiency. It can occur in anyone... more...

Related Diseases for Marasmus

Diseases related to Marasmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 30.5 TTR SHBG INS CD4 ANXA6 ALB
2 protein-energy malnutrition 30.0 TTR SHBG IGF1 ALB
3 insulin-like growth factor i 28.9 SHBG INS IGFBP3 IGF1 GH1
4 anorexia nervosa 28.8 TTR SHBG INS IGFBP3 IGF1 GH1
5 aquagenic syringeal acrokeratoderma 10.9
6 inhibited female orgasm 10.3 SHBG ALB
7 mixed cerebral palsy 10.3 TTR SHBG
8 complete androgen insensitivity syndrome 10.3 SHBG IGFBP3
9 hyperproinsulinemia 10.2 SHBG INS
10 critical illness polyneuropathy 10.2 INS ALB
11 inflammatory and toxic neuropathy 10.2 INS ALB
12 generalized atherosclerosis 10.2 INS ALB
13 benign essential hypertension 10.2 INS ALB
14 severe nonproliferative diabetic retinopathy 10.2 INS ALB
15 analbuminemia 10.2 TTR ALB
16 paralytic ileus 10.2 INS ALB
17 protein-deficiency anemia 10.2 INS GH1
18 kidney hypertrophy 10.2 INS ALB
19 cork-handlers' disease 10.2 CD4 ALB
20 riedel's fibrosing thyroiditis 10.2 CD4 ALB
21 asphyxia neonatorum 10.2 INS ALB
22 epidural abscess 10.2 CD4 ALB
23 diencephalic astrocytoma 10.2 INS GH1
24 meningovascular neurosyphilis 10.2 CD4 ALB
25 background diabetic retinopathy 10.2 INS ALB
26 splenic abscess 10.2 CD4 ALB
27 amyloid tumor 10.2 TTR INS
28 steroid inherited metabolic disorder 10.2 SHBG INS
29 gastrointestinal tuberculosis 10.2 CD4 ALB
30 intestinal tuberculosis 10.2 CD4 ALB
31 granulomatous hepatitis 10.2 CD4 ALB
32 functional gastric disease 10.2 INS ALB
33 esophageal varix 10.2 INS ALB
34 hypothalamic disease 10.2 INS GH1
35 angular cheilitis 10.2 CD4 ALB
36 splenic tuberculosis 10.2 CD4 ALB
37 anti-basement membrane glomerulonephritis 10.2 CD4 ALB
38 adenohypophysitis 10.2 GH1 CD4
39 lung abscess 10.2 CD4 ALB
40 abdominal tuberculosis 10.2 CD4 ALB
41 bell's palsy 10.2 CD4 ALB
42 hyperthyroxinemia 10.2 TTR ALB
43 whipple disease 10.2 CD4 ALB
44 pleural empyema 10.2 CD4 ALB
45 miliary tuberculosis 10.2 CD4 ALB
46 cranial nerve palsy 10.2 CD4 ALB
47 chronic meningitis 10.2 CD4 ALB
48 parotitis 10.2 CD4 ALB
49 immunodeficiency 43 10.2 CD4 ALB
50 vaginal discharge 10.2 CD4 ALB

Comorbidity relations with Marasmus via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bronchitis Chronic Kidney Disease
Decubitus Ulcer Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Iron Deficiency Anemia Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Postinflammatory Pulmonary Fibrosis Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to Marasmus

Symptoms & Phenotypes for Marasmus

Symptoms:

12
  • emaciation

Drugs & Therapeutics for Marasmus

Drugs for Marasmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Disinfectants
3 Nutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Safe Drinking Water in Community Based Treatment of Severe Acute Malnutrition Unknown status NCT02751476
2 Developmental Contribution to Macronutrient Selection and Appetite Control in Adult Survivors of Kwashiorkor and Marasmus Completed NCT02257593
3 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers of Children < 5 Years Old Completed NCT01790815

Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

Anatomical Context for Marasmus

MalaCards organs/tissues related to Marasmus:

40
Kidney, Liver, Thyroid, Bone Marrow, Bone, Skin, Thymus

Publications for Marasmus

Articles related to Marasmus:

(show top 50) (show all 692)
# Title Authors PMID Year
1
["Free" iron, transferrin and ferritin levels in serum and their relation with severe malnutrition]. 61 54
17266850 2007
2
The evaluation of serum leptin level and other hormonal parameters in children with severe malnutrition. 54 61
15087254 2004
3
Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. 61 54
12581501 2002
4
Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. 54 61
10909989 2000
5
Brainstem auditory and visual evoked potentials in children with protein-energy malnutrition. 54 61
10618879 1999
6
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. 61 54
9625094 1998
7
Growth hormone-binding proteins and insulin-like growth factor-binding proteins in protein-energy malnutrition, before and after nutritional rehabilitation. 54 61
8929859 1996
8
Glutathione and association antioxidant systems in protein energy malnutrition: results of a study in Nigeria. 54 61
7744309 1995
9
Protein-losing enteropathy in Transkeian children with morbid protein-energy malnutrition. 61 54
8211522 1993
10
Effects of cortisol and growth hormone on the metabolism of liver and bone in children with malnutrition. 61 54
1509526 1992
11
Difference between kwashiorkor and marasmus: Comparative meta-analysis of pathogenic characteristics and implications for treatment. 61
33359074 2021
12
Hydrogen isotopes in serial hair samples record season of death in a mummified child from 19th century San Francisco, CA. 61
32888333 2020
13
Liver disease in obesity and underweight: the two sides of the coin. A narrative review. 61
33150534 2020
14
Predictors of undesirable treatment outcomes of severe acute malnutrition among inpatient children in Addis Ababa, Ethiopia: a retrospective cohort study. 61
33036594 2020
15
Aflatoxins in organs and biological samples from children affected by kwashiorkor, marasmus and marasmic-kwashiorkor: A scoping review. 61
32693007 2020
16
Anaerococcusmarasmi sp. nov., a new bacterium isolated from human gut microbiota. 61
32211195 2020
17
Clinico-biochemical profile of sick children with severe acute malnutrition. 61
32754486 2020
18
Phenotype is sustained during hospital readmissions following treatment for complicated severe malnutrition among Kenyan children: A retrospective cohort study. 61
31756291 2020
19
Clinical case report: A case of Turner syndrome with Graves' disease. 61
32176101 2020
20
Effect of Malnutrition on Hearing Loss in Children. 61
31821252 2020
21
Gut Microbiota Alteration is Characterized by a Proteobacteria and Fusobacteria Bloom in Kwashiorkor and a Bacteroidetes Paucity in Marasmus. 61
31235833 2019
22
Clostridium pacaense: a new species within the genus Clostridium. 61
30740227 2019
23
Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study. 61
30901050 2019
24
Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity. 61
30598443 2019
25
Time-to-recovery from severe acute malnutrition in children 6-59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study. 61
30691437 2019
26
High-performance liquid chromatographic analysis explores the potential antioxidative agents of Argyreia argentea ARN. EX CHOISY extract. 61
30906135 2019
27
Primary diffuse large B-cell lymphoma as a chest-wall mass: A case report. 61
30461640 2018
28
Brown tumor of multiple facial bones associated with primary hyperparathyroidism: A clinical case report. 61
30113484 2018
29
Diagnosing clinical malnutrition: Perspectives from the past and implications for the future. 61
29908677 2018
30
Genome sequence and description of Clostridium niameyense sp. nov., isolated from a human with marasmus in Nigeria. 61
29922472 2018
31
Safety of a heat-stable rotavirus vaccine among children in Niger: Data from a phase 3, randomized, double-blind, placebo-controlled trial. 61
29752026 2018
32
Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. 61
29504978 2018
33
Identification of Two Novel LAMA2 Mutations in a Chinese Patient with Congenital Muscular Dystrophy. 61
29487616 2018
34
Malaria and Malnutrition: Kwashiorkor Associated with Low Levels of Parasitaemia. 61
30533212 2018
35
Outcomes of children aged 6-59 months with severe acute malnutrition at the GADO Outpatient Therapeutic Center in Cameroon. 61
29361980 2018
36
Aflatoxin exposure in Nigerian children with severe acute malnutrition. 61
29175577 2018
37
Developmental and behavioural problems in children with severe acute malnutrition in Malawi: A cross-sectional study. 61
29302321 2017
38
Monitoring and discharging children being treated for severe acute malnutrition using mid-upper arm circumference: secondary data analysis from rural Gambia. 61
28810666 2017
39
[Acute malnutrition in children]. 61
28504629 2017
40
Molecular Evidence for Differential Long-term Outcomes of Early Life Severe Acute Malnutrition. 61
28330812 2017
41
Treatment outcomes of severe acute malnutrition in children treated within Outpatient Therapeutic Program (OTP) at Wolaita Zone, Southern Ethiopia: retrospective cross-sectional study. 61
28279227 2017
42
The clinical spectrum of severe acute malnutrition in children in Cameroon: a hospital-based study in Yaounde, Cameroon. 61
28164028 2017
43
Mortality and morbidity trends and predictors of mortality in under-five children with severe acute malnutrition in Hadiya zone, South Ethiopia: a four-year retrospective review of hospital-based records (2012-2015). 61
32153800 2017
44
The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management. 61
28559814 2017
45
A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula. 61
26990240 2016
46
Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition. 61
27807038 2016
47
Analysis of clinical characteristics and treatment of pancreatic cystic tumors. 61
27877011 2016
48
Functional and structural abnormalities of the kidney and urinary tract in severely malnourished children - A hospital based study. 61
27882009 2016
49
Prevalence and outcome of severe malnutrition in children less than five-year-old in Omdurman Paediatric Hospital, Sudan. 61
27651550 2016
50
Treatment outcome and factors affecting time to recovery in children with severe acute malnutrition treated at outpatient therapeutic care program. 61
27396484 2016

Variations for Marasmus

Expression for Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for Marasmus

Pathways related to Marasmus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 INS IGFBP3 IGF1 GH1
2
Show member pathways
11.84 INS IGF1 GH1
3 11.62 INS IGF1 ALB
4 11.55 INS IGF1 GH1
5 11.36 INS IGFBP3 IGF1
6 11.11 INS IGFBP3 IGF1
7 10.69 IGFBP3 IGF1
8 10.44 TTR INS ALB

GO Terms for Marasmus

Cellular components related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 TTR INS IGFBP3 IGF1 GH1 ALB
2 extracellular region GO:0005576 9.8 TTR SHBG INS IGFBP3 IGF1 GH1
3 endoplasmic reticulum lumen GO:0005788 9.46 INS IGFBP3 CD4 ALB
4 endosome lumen GO:0031904 9.32 INS GH1
5 insulin-like growth factor ternary complex GO:0042567 8.96 IGFBP3 IGF1
6 insulin-like growth factor binding protein complex GO:0016942 8.62 IGFBP3 IGF1

Biological processes related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 CD4 GH1 IGF1
2 positive regulation of MAPK cascade GO:0043410 9.46 CD4 IGF1 IGFBP3 INS
3 positive regulation of mitotic nuclear division GO:0045840 9.43 IGF1 INS
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 GH1 IGF1 INS
5 positive regulation of glycolytic process GO:0045821 9.4 IGF1 INS
6 positive regulation of glycogen biosynthetic process GO:0045725 9.37 IGF1 INS
7 cellular protein metabolic process GO:0044267 9.35 ALB IGF1 IGFBP3 INS TTR
8 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.8 GH1 IGF1 IGFBP3

Molecular functions related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 INS IGF1
2 insulin-like growth factor receptor binding GO:0005159 8.96 INS IGF1
3 hormone activity GO:0005179 8.92 TTR INS IGF1 GH1

Sources for Marasmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....