Aliases & Classifications for Marasmus

MalaCards integrated aliases for Marasmus:

Name: Marasmus 12 54 15 17 71
Nutritional Marasmus 12 32
Nutritional Atrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12328
ICD9CM 34 261
MeSH 43 D011502
SNOMED-CT 67 29740003
ICD10 32 E41
UMLS 71 C0086588

Summaries for Marasmus

Disease Ontology : 12 A protein-energy malnutrition that is characterized by severe caloric deprivation, has symptom emaciation, decreased height and weight gain, and decreased metabolism with hypothermia, bradycardia, and constipation, and has material basis in severe caloric deprivation.

MalaCards based summary : Marasmus, also known as nutritional marasmus, is related to kwashiorkor and protein-energy malnutrition, and has symptoms including emaciation An important gene associated with Marasmus is ALB (Albumin), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Adipogenesis. The drugs Ceftriaxone and Nutrients have been mentioned in the context of this disorder. Affiliated tissues include liver, pituitary and bone.

Wikipedia : 74 Marasmus is a form of severe malnutrition characterized by energy deficiency. It can occur in anyone... more...

Related Diseases for Marasmus

Diseases related to Marasmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 kwashiorkor 30.7 TTR SHBG OTP INS CD4 ANXA6
2 protein-energy malnutrition 30.1 TTR LEPQTL1 IGF1 ALB
3 deficiency anemia 29.5 TTR INS IGF1 ALB
4 insulin-like growth factor i 29.2 SHBG INS IGFBP3 IGF1 GH1
5 anorexia nervosa 28.5 TTR SHBG LEPQTL1 INS IGFBP3 IGF1
6 aquagenic syringeal acrokeratoderma 11.2
7 47, xxy 10.5 SHBG IGFBP3
8 hypoadrenalism 10.4 SHBG GH1
9 blind loop syndrome 10.4 TTR ALB
10 complete androgen insensitivity syndrome 10.4 SHBG IGFBP3
11 mixed cerebral palsy 10.3 TTR SHBG
12 riedel's fibrosing thyroiditis 10.3 CD4 ALB
13 cork-handlers' disease 10.3 CD4 ALB
14 critical illness polyneuropathy 10.3 INS ALB
15 diarrhea 10.3
16 hyperproinsulinemia 10.3 SHBG INS
17 protein-deficiency anemia 10.3 INS GH1
18 inflammatory and toxic neuropathy 10.3 INS ALB
19 generalized atherosclerosis 10.3 INS ALB
20 severe nonproliferative diabetic retinopathy 10.3 INS ALB
21 benign pleural mesothelioma 10.3 TTR INS
22 chronic graft versus host disease 10.3 CD4 ALB
23 analbuminemia 10.3 TTR ALB
24 kidney hypertrophy 10.3 INS ALB
25 meningovascular neurosyphilis 10.3 CD4 ALB
26 adenohypophysitis 10.3 GH1 CD4
27 granulomatous hepatitis 10.3 CD4 ALB
28 gastrointestinal tuberculosis 10.3 CD4 ALB
29 intestinal tuberculosis 10.3 CD4 ALB
30 anti-basement membrane glomerulonephritis 10.3 CD4 ALB
31 benign essential hypertension 10.3 INS ALB
32 angular cheilitis 10.3 CD4 ALB
33 abdominal tuberculosis 10.3 CD4 ALB
34 bile acid synthesis defect, congenital, 1 10.3 TTR ALB
35 lung abscess 10.3 CD4 ALB
36 parotitis 10.3 CD4 ALB
37 background diabetic retinopathy 10.2 INS ALB
38 corticosteroid allergy 10.2 CD4 ALB
39 miliary tuberculosis 10.2 CD4 ALB
40 cranial nerve palsy 10.2 CD4 ALB
41 pleural empyema 10.2 CD4 ALB
42 diabetes mellitus, insulin-dependent, 23 10.2 INS CD4
43 slipped capital femoral epiphysis 10.2 IGFBP3 IGF1
44 autoimmune disease of peripheral nervous system 10.2 CD4 ALB
45 aromatase deficiency 10.2 INS GH1
46 taeniasis 10.2 CD4 ALB
47 xerophthalmia 10.2 TTR CD4
48 graves disease 1 10.2 SHBG INS ALB
49 rickets 10.2
50 keratomalacia 10.2

Comorbidity relations with Marasmus via Phenotypic Disease Network (PDN): (show all 20)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Bronchitis Decubitus Ulcer
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Iron Deficiency Anemia
Osteoporosis Paralytic Ileus
Parkinson Disease, Late-Onset Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Marasmus:



Diseases related to Marasmus

Symptoms & Phenotypes for Marasmus

Symptoms:

12
  • emaciation

Drugs & Therapeutics for Marasmus

Drugs for Marasmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
2 Nutrients Phase 4
3 Anti-Infective Agents Phase 4
4 Trace Elements Phase 4
5 Micronutrients Phase 4
6 Anti-Bacterial Agents Phase 4
7
Iron Approved, Experimental 7439-89-6, 15438-31-0 23925 27284
8 Disinfectants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children Completed NCT00968370 Phase 4
2 Effectiveness of Safe Drinking Water in Community Based Treatment of Severe Acute Malnutrition Unknown status NCT02751476
3 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers of Children < 5 Years Old Completed NCT01790815
4 Developmental Contribution to Macronutrient Selection and Appetite Control in Adult Survivors of Kwashiorkor and Marasmus Completed NCT02257593
5 Is Helicobacter Pylori Infection a Cause or Treatment Failure of Iron Deficiency Anemia in Children in Bangladesh? Completed NCT00284700 Iron

Search NIH Clinical Center for Marasmus

Genetic Tests for Marasmus

Anatomical Context for Marasmus

MalaCards organs/tissues related to Marasmus:

40
Liver, Pituitary, Bone, Kidney, Thyroid, Brain, Skin

Publications for Marasmus

Articles related to Marasmus:

(show top 50) (show all 683)
# Title Authors PMID Year
1
["Free" iron, transferrin and ferritin levels in serum and their relation with severe malnutrition]. 54 61
17266850 2007
2
The evaluation of serum leptin level and other hormonal parameters in children with severe malnutrition. 54 61
15087254 2004
3
Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. 54 61
12581501 2002
4
Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. 54 61
10909989 2000
5
Brainstem auditory and visual evoked potentials in children with protein-energy malnutrition. 54 61
10618879 1999
6
Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. 54 61
9625094 1998
7
Growth hormone-binding proteins and insulin-like growth factor-binding proteins in protein-energy malnutrition, before and after nutritional rehabilitation. 54 61
8929859 1996
8
Glutathione and association antioxidant systems in protein energy malnutrition: results of a study in Nigeria. 54 61
7744309 1995
9
Protein-losing enteropathy in Transkeian children with morbid protein-energy malnutrition. 54 61
8211522 1993
10
Effects of cortisol and growth hormone on the metabolism of liver and bone in children with malnutrition. 54 61
1509526 1992
11
Effect of Malnutrition on Hearing Loss in Children. 61
31821252 2020
12
Phenotype is sustained during hospital readmissions following treatment for complicated severe malnutrition among Kenyan children: A retrospective cohort study. 61
31756291 2019
13
Gut Microbiota Alteration is Characterized by a Proteobacteria and Fusobacteria Bloom in Kwashiorkor and a Bacteroidetes Paucity in Marasmus. 61
31235833 2019
14
Clostridium pacaense: a new species within the genus Clostridium. 61
30740227 2019
15
Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study. 61
30901050 2019
16
Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity. 61
30598443 2019
17
High-performance liquid chromatographic analysis explores the potential antioxidative agents of Argyreia argentea ARN. EX CHOISY extract. 61
30906135 2019
18
Time-to-recovery from severe acute malnutrition in children 6-59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study. 61
30691437 2019
19
Primary diffuse large B-cell lymphoma as a chest-wall mass: A case report. 61
30461640 2018
20
Brown tumor of multiple facial bones associated with primary hyperparathyroidism: A clinical case report. 61
30113484 2018
21
Diagnosing clinical malnutrition: Perspectives from the past and implications for the future. 61
29908677 2018
22
Genome sequence and description of Clostridium niameyense sp. nov., isolated from a human with marasmus in Nigeria. 61
29922472 2018
23
Safety of a heat-stable rotavirus vaccine among children in Niger: Data from a phase 3, randomized, double-blind, placebo-controlled trial. 61
29752026 2018
24
Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. 61
29504978 2018
25
Malaria and Malnutrition: Kwashiorkor Associated with Low Levels of Parasitaemia. 61
30533212 2018
26
Identification of Two Novel LAMA2 Mutations in a Chinese Patient with Congenital Muscular Dystrophy. 61
29487616 2018
27
Outcomes of children aged 6-59 months with severe acute malnutrition at the GADO Outpatient Therapeutic Center in Cameroon. 61
29361980 2018
28
Aflatoxin exposure in Nigerian children with severe acute malnutrition. 61
29175577 2018
29
Developmental and behavioural problems in children with severe acute malnutrition in Malawi: A cross-sectional study. 61
29302321 2017
30
Monitoring and discharging children being treated for severe acute malnutrition using mid-upper arm circumference: secondary data analysis from rural Gambia. 61
28810666 2017
31
[Acute malnutrition in children]. 61
28504629 2017
32
Molecular Evidence for Differential Long-term Outcomes of Early Life Severe Acute Malnutrition. 61
28330812 2017
33
Treatment outcomes of severe acute malnutrition in children treated within Outpatient Therapeutic Program (OTP) at Wolaita Zone, Southern Ethiopia: retrospective cross-sectional study. 61
28279227 2017
34
The clinical spectrum of severe acute malnutrition in children in Cameroon: a hospital-based study in Yaounde, Cameroon. 61
28164028 2017
35
The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management. 61
28559814 2017
36
A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula. 61
26990240 2016
37
Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition. 61
27807038 2016
38
Analysis of clinical characteristics and treatment of pancreatic cystic tumors. 61
27877011 2016
39
Functional and structural abnormalities of the kidney and urinary tract in severely malnourished children - A hospital based study. 61
27882009 2016
40
Prevalence and outcome of severe malnutrition in children less than five-year-old in Omdurman Paediatric Hospital, Sudan. 61
27651550 2016
41
Developmental contributions to macronutrient selection: a randomized controlled trial in adult survivors of malnutrition. 61
26817484 2016
42
Treatment outcome and factors affecting time to recovery in children with severe acute malnutrition treated at outpatient therapeutic care program. 61
27396484 2016
43
Body mass index, body fat, and nutritional status of patients with heart failure: The PLICA study. 61
25573807 2015
44
The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. 61
26164745 2015
45
The ontogeny of saliva secretion in infants and esophagoprotection. 61
26039837 2015
46
Management of severe acute malnutrition in low-income and middle-income countries. 61
25421910 2015
47
Malnutrition in acutely ill children at the paediatric emergency unit in a tertiary hospital in Nigeria. 61
25838626 2015
48
Treatment Outcome of Severe Acute Malnutrition Cases at the Tamale Teaching Hospital. 61
26064678 2015
49
Mortality and morbidity patterns in under-five children with severe acute malnutrition (SAM) in Zambia: a five-year retrospective review of hospital-based records (2009-2013). 61
25937927 2015
50
Synchronous of gastric adenocarcinoma and schwannoma: report of a case and review of literatures. 61
25755816 2015

Variations for Marasmus

Expression for Marasmus

Search GEO for disease gene expression data for Marasmus.

Pathways for Marasmus

GO Terms for Marasmus

Cellular components related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 TTR INS IGFBP3 IGF1 GH1 BCHE
2 extracellular region GO:0005576 9.86 TTR SHBG INS IGFBP3 IGF1 GH1
3 endosome lumen GO:0031904 9.37 INS GH1
4 insulin-like growth factor ternary complex GO:0042567 9.16 IGFBP3 IGF1
5 endoplasmic reticulum lumen GO:0005788 9.02 INS IGFBP3 CD4 BCHE ALB
6 insulin-like growth factor binding protein complex GO:0016942 8.96 IGFBP3 IGF1

Biological processes related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 IGF1 GH1 CD4
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.5 INS IGF1 GH1
3 positive regulation of MAPK cascade GO:0043410 9.46 INS IGFBP3 IGF1 CD4
4 positive regulation of glycolytic process GO:0045821 9.43 INS IGF1
5 positive regulation of glycogen biosynthetic process GO:0045725 9.4 INS IGF1
6 cellular protein metabolic process GO:0044267 9.35 TTR INS IGFBP3 IGF1 ALB
7 negative regulation of protein oligomerization GO:0032460 9.26 INS ALB
8 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.8 IGFBP3 IGF1 GH1

Molecular functions related to Marasmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 INS IGF1
2 insulin-like growth factor receptor binding GO:0005159 8.96 INS IGF1
3 hormone activity GO:0005179 8.92 TTR INS IGF1 GH1

Sources for Marasmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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