MHF
MCID: MRB001
MIFTS: 40

Marburg Hemorrhagic Fever (MHF)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Marburg Hemorrhagic Fever

MalaCards integrated aliases for Marburg Hemorrhagic Fever:

Name: Marburg Hemorrhagic Fever 12 52 58 3 15 17
Marburg Virus Disease 12 52 58 43 71 32
Marburg Disease 12 52
Green Monkey Disease 58
Mhf 58

Characteristics:

Orphanet epidemiological data:

58
marburg hemorrhagic fever
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Marburg Hemorrhagic Fever

CDC : 3 Marburg hemorrhagic fever (Marburg HF) is a rare but severe hemorrhagic fever which affects both humans and non-human primates. Marburg HF is caused by Marburg virus, a genetically unique zoonotic (or, animal-borne) RNA virus of the filovirus family. The five species of Ebola virus are the only other known members of the filovirus family. Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). Thirty-one people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them. Seven deaths were reported. The first people infected had been exposed to imported African green monkeys or their tissues while conducting research.

MalaCards based summary : Marburg Hemorrhagic Fever, also known as marburg virus disease, is related to lassa fever and ebola hemorrhagic fever, and has symptoms including vomiting, fever and abdominal pain. An important gene associated with Marburg Hemorrhagic Fever is GTPBP1 (GTP Binding Protein 1). The drugs Pharmaceutical Solutions and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells, and related phenotypes are fatigue and fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Marburgvirus, which is transmitted by contact with the body fluids of an infected person. The infection has symptom fever, has symptom chills, has symptom headache, has symptom myalgia, has symptom maculopapular rash on the trunk, has symptom nausea, has symptom vomiting, has symptom chest pain, has symptom sore throat, has symptom abdominal pain, has symptom diarrhea, and has symptom bleeding.

Wikipedia : 74 Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a severe illness of humans and... more...

Related Diseases for Marburg Hemorrhagic Fever

Diseases related to Marburg Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 lassa fever 28.6 SCARA3 NPC1 IFNA1 GTPBP1 GP2 CLEC4G
2 ebola hemorrhagic fever 28.0 SCARA3 NPC1 IFNA1 GTPBP1 GP2 FURIN
3 fanconi anemia, complementation group a 10.5
4 blessig's cysts 10.4 GTPBP1 GP2
5 brazilian hemorrhagic fever 10.4 GTPBP1 GP2
6 venezuelan hemorrhagic fever 10.4 GTPBP1 GP2
7 bolivian hemorrhagic fever 10.4 GTPBP1 GP2
8 viral hemorrhagic fever 10.3
9 gastrointestinal tuberculosis 10.3 GP2 CD40LG
10 zika fever 10.2 SCARA3 CD40LG
11 headache 10.2
12 cryoglobulinemia, familial mixed 10.2 IFNA1 CD40LG
13 fanconi anemia, complementation group d2 10.2
14 dementia 10.2
15 stenotrophomonas maltophilia infection 10.2
16 autoimmune disease of cardiovascular system 10.2 GTPBP1 CD40LG
17 monkeypox 10.2 IFNA1 CD40LG
18 bell's palsy 10.2 IFNA1 CD40LG
19 gray platelet syndrome 10.1 GTPBP1 GP2 CD40LG
20 eastern equine encephalitis 10.1 IFNA1 CD40LG
21 west nile encephalitis 10.1 CLEC4M CD40LG
22 pure red-cell aplasia 10.1 IFNA1 CD40LG
23 west nile fever 10.1 CLEC4M CD40LG
24 hepatitis d 10.1 IFNA1 CD40LG
25 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
26 ocular motor apraxia 10.1
27 exanthem 10.1
28 disseminated intravascular coagulation 10.1
29 diarrhea 10.1
30 cholera 10.1
31 hemorrhagic disease 10.1
32 anuria 10.1
33 lymphopenia 10.1
34 severe combined immunodeficiency 10.1
35 stomatitis 10.1
36 posttransplant acute limbic encephalitis 10.1
37 swine influenza 10.1 SCARA3 IFNA1 GP2
38 chickenpox 10.1 IFNA1 CD40LG
39 trichomoniasis 10.1 CD40LG CCL4L1
40 murray valley encephalitis 10.0 FURIN CD40LG
41 herpangina 10.0 IFNA1 CD40LG
42 rabies 10.0
43 hepatitis a 10.0
44 acute kidney tubular necrosis 10.0
45 uveitis 10.0
46 poliomyelitis 10.0
47 dengue shock syndrome 9.9 IFNA1 CLEC4M CD40LG
48 autoimmune disease of exocrine system 9.9 IFNA1 CD40LG
49 crimean-congo hemorrhagic fever 9.8 IFNA1 FURIN
50 middle east respiratory syndrome 9.8 SCARA3 FURIN

Graphical network of the top 20 diseases related to Marburg Hemorrhagic Fever:



Diseases related to Marburg Hemorrhagic Fever

Symptoms & Phenotypes for Marburg Hemorrhagic Fever

Human phenotypes related to Marburg Hemorrhagic Fever:

58 31 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 menometrorrhagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0400008
4 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
5 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
6 hematuria 58 31 frequent (33%) Frequent (79-30%) HP:0000790
7 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
8 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
9 gastrointestinal hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0002239
10 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
11 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
12 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
13 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
14 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
15 jaundice 58 31 frequent (33%) Frequent (79-30%) HP:0000952
16 recurrent pharyngitis 58 31 frequent (33%) Frequent (79-30%) HP:0100776
17 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
18 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
19 leukopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001882
20 pancreatitis 58 31 frequent (33%) Frequent (79-30%) HP:0001733
21 subconjunctival hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0011896
22 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
23 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
24 abnormal bleeding 58 Occasional (29-5%)

Symptoms:

12 (show all 12)
  • vomiting
  • fever
  • abdominal pain
  • myalgia
  • chest pain
  • headache
  • diarrhea
  • nausea
  • chills
  • sore throat
  • bleeding
  • maculopapular rash on the trunk

Drugs & Therapeutics for Marburg Hemorrhagic Fever

Drugs for Marburg Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1
2 Vaccines Phase 1
3 polysaccharide-K Phase 1
4 Immunologic Factors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Dose-Escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-6003 in Healthy Adult Volunteers Completed NCT01353040 Phase 1 AVI-6003;Placebo
2 A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Dose-Escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers Completed NCT01566877 Phase 1 AVI-7288
3 RV 507: A Phase I Open-Label, Dose-Escalation Clinical Trial to Evaluate the Safety, Tolerability and Immunogenicity of the Marburg Chimpanzee Adenovirus Vector Vaccine, VRC-MARADC087-00-VP (cAd3-Marburg), in Healthy Adults Completed NCT03475056 Phase 1
4 A Phase I Trial to Utilize Systems Biology Approaches to Examine the Safety, Immunogenicity, and 'Omics Response to MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Completed NCT02891980 Phase 1
5 A Phase IB Study to Evaluate the Safety and Immunogenicity of an Ebola DNA Plasmid Vaccine, VRC-EBODNA023-00-VP, and a Marburg DNA Plasmid Vaccine, VRC-MARDNA025-00-VP, in Healthy Adults in Kampala, Uganda Completed NCT00997607 Phase 1
6 VRC 206: A Phase I Study to Evaluate the Safety and Immunogenicity of an Ebola DNA Plasmid Vaccine, VRC-EBODNA023-00-VP, and a Marburg DNA Plasmid Vaccine, VRC-MARDNA025-00-VP, in Healthy Adults Completed NCT00605514 Phase 1 VRC-EBODNA023-00-VP;VRC-MARDNA025-00-VP
7 A Phase 1 Double-blind, Placebo Controlled, Dose Ranging Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Galidesivir (BCX4430) Administered as Single Doses Via Intravenous Infusion in Healthy Subjects Active, not recruiting NCT03800173 Phase 1 galidesivir;placebo

Search NIH Clinical Center for Marburg Hemorrhagic Fever

Cochrane evidence based reviews: marburg virus disease

Genetic Tests for Marburg Hemorrhagic Fever

Anatomical Context for Marburg Hemorrhagic Fever

MalaCards organs/tissues related to Marburg Hemorrhagic Fever:

40
Skin, Testes, B Cells

Publications for Marburg Hemorrhagic Fever

Articles related to Marburg Hemorrhagic Fever:

(show top 50) (show all 134)
# Title Authors PMID Year
1
Remdesivir (GS-5734) is Efficacious in Cynomolgus Macaques Infected with Marburg Virus. 61
32479636 2020
2
A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967. 61
32404328 2020
3
Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. 61
31980636 2020
4
Marburg virus pathogenesis - differences and similarities in humans and animal models. 61
31888676 2019
5
Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators. 61
31801842 2019
6
Great apes in the emergence of infectious diseases. 61
31884984 2019
7
Marburgvirus in Egyptian Fruit Bats, Zambia. 61
31146800 2019
8
Clinical, Histopathologic, and Immunohistochemical Characterization of Experimental Marburg Virus Infection in A Natural Reservoir Host, the Egyptian Rousette Bat (Rousettus aegyptiacus). 61
30832364 2019
9
Marburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findings. 61
30883555 2019
10
A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine Model. 61
30567978 2019
11
Lowland grazing and Marburg virus disease (MVD) outbreak in Kween district, Eastern Uganda. 61
30704427 2019
12
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. 61
29982632 2018
13
Monoclonal Antibody Cocktail Protects Hamsters From Lethal Marburg Virus Infection. 61
29889266 2018
14
Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters. 61
30192975 2018
15
The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts. 61
30261226 2018
16
Infection Rates and Risk Factors for Infection Among Health Workers During Ebola and Marburg Virus Outbreaks: A Systematic Review. 61
30202878 2018
17
New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. 61
30053050 2018
18
Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease. 61
30285648 2018
19
Small Animal Models for Evaluating Filovirus Countermeasures. 61
29457711 2018
20
Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis. 61
29031848 2017
21
N-Heterocyclic borneol derivatives as inhibitors of Marburg virus glycoprotein-mediated VSIV pseudotype entry. 61
30108738 2017
22
Ecological Niche Modeling for Filoviruses: A Risk Map for Ebola and Marburg Virus Disease Outbreaks in Uganda. 61
29034123 2017
23
Knowledge and attitude towards Ebola and Marburg virus diseases in Uganda using quantitative and participatory epidemiology techniques. 61
28892520 2017
24
Isolated Case of Marburg Virus Disease, Kampala, Uganda, 2014. 61
28518032 2017
25
Filoviruses and bats. 61
28603449 2017
26
Filovirus Research: How it Began. 61
28766193 2017
27
A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever. 61
27976688 2016
28
Notes from the Field: Rift Valley Fever Response - Kabale District, Uganda, March 2016. 61
27811840 2016
29
How severe and prevalent are Ebola and Marburg viruses? A systematic review and meta-analysis of the case fatality rates and seroprevalence. 61
27887599 2016
30
Polio infrastructure strengthened disease outbreak preparedness and response in the WHO African Region. 61
27378681 2016
31
Ebola virus disease candidate vaccines under evaluation in clinical trials. 61
27160784 2016
32
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. 61
26589246 2016
33
Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012. 61
26209681 2015
34
Comparison of the Pathogenesis of the Angola and Ravn Strains of Marburg Virus in the Outbred Guinea Pig Model. 61
26092858 2015
35
Mapping the zoonotic niche of Marburg virus disease in Africa. 61
25820266 2015
36
A Comparison of the Pathogenesis of Marburg Virus Disease in Humans and Nonhuman Primates and Evaluation of the Suitability of These Animal Models for Predicting Clinical Efficacy under the 'Animal Rule'. 61
26141449 2015
37
Oral shedding of Marburg virus in experimentally infected Egyptian fruit bats (Rousettus aegyptiacus). 61
25375951 2015
38
Calculation of incubation period and serial interval from multiple outbreaks of Marburg virus disease. 61
25495697 2014
39
Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus. 61
25142608 2014
40
Diagnostic schemes for reducing epidemic size of African viral hemorrhagic fever outbreaks. 61
25212079 2014
41
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. 61
24590073 2014
42
Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences. 61
24556792 2014
43
Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. 61
23255566 2013
44
Forty-five years of Marburg virus research. 61
23202446 2012
45
A review of filovirus work and facilities at the Defence Science and Technology Laboratory Porton Down. 61
23012627 2012
46
Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever. 61
22710186 2012
47
Ebola and Marburg hemorrhagic fevers: neglected tropical diseases? 61
22761967 2012
48
Advanced morpholino oligomers: a novel approach to antiviral therapy. 61
22353544 2012
49
Infection control during filoviral hemorrhagic Fever outbreaks. 61
22529631 2012
50
Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection. 61
23055920 2012

Variations for Marburg Hemorrhagic Fever

Expression for Marburg Hemorrhagic Fever

Search GEO for disease gene expression data for Marburg Hemorrhagic Fever.

Pathways for Marburg Hemorrhagic Fever

GO Terms for Marburg Hemorrhagic Fever

Biological processes related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.56 NPC1 FURIN CLEC4M CLEC4G
2 B cell proliferation GO:0042100 9.16 IFNA1 CD40LG
3 leukocyte cell-cell adhesion GO:0007159 8.96 CLEC4M CD40LG
4 viral entry into host cell GO:0046718 8.8 NPC1 CLEC4M CLEC4G

Molecular functions related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.8 NPC1 CLEC4M CLEC4G

Sources for Marburg Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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