MHF
MCID: MRB001
MIFTS: 43

Marburg Hemorrhagic Fever (MHF)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Marburg Hemorrhagic Fever

MalaCards integrated aliases for Marburg Hemorrhagic Fever:

Name: Marburg Hemorrhagic Fever 12 53 59 3 15 17
Marburg Virus Disease 12 53 59 44 72 33
Marburg Disease 12 53
Green Monkey Disease 59
Mhf 59

Characteristics:

Orphanet epidemiological data:

59
marburg hemorrhagic fever
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:4327
MeSH 44 D008379
NCIt 50 C84883
SNOMED-CT 68 77503002
ICD10 33 A98.3
ICD10 via Orphanet 34 A98.3
UMLS via Orphanet 73 C0024788
Orphanet 59 ORPHA99826
UMLS 72 C0024788

Summaries for Marburg Hemorrhagic Fever

CDC : 3 Marburg hemorrhagic fever (Marburg HF) is a rare but severe hemorrhagic fever which affects both humans and non-human primates. Marburg HF is caused by Marburg virus, a genetically unique zoonotic (or, animal-borne) RNA virus of the filovirus family. The five species of Ebola virus are the only other known members of the filovirus family. Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). Thirty-one people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them. Seven deaths were reported. The first people infected had been exposed to imported African green monkeys or their tissues while conducting research.

MalaCards based summary : Marburg Hemorrhagic Fever, also known as marburg virus disease, is related to hepatitis a and trench fever, and has symptoms including fever, vomiting and abdominal pain. An important gene associated with Marburg Hemorrhagic Fever is NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2), and among its related pathways/superpathways are Diseases associated with the TLR signaling cascade and C-type lectin receptor signaling pathway. The drugs Pharmaceutical Solutions and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells, and related phenotypes are fever and fatigue

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Marburgvirus, which is transmitted by contact with the body fluids of an infected person. The infection has symptom fever, has symptom chills, has symptom headache, has symptom myalgia, has symptom maculopapular rash on the trunk, has symptom nausea, has symptom vomiting, has symptom chest pain, has symptom sore throat, has symptom abdominal pain, has symptom diarrhea, and has symptom bleeding.

Wikipedia : 75 Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a severe illness of humans and... more...

Related Diseases for Marburg Hemorrhagic Fever

Diseases related to Marburg Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 hepatitis a 30.1 TNF GPT F2
2 trench fever 10.5 TNF TLR4
3 listeria meningitis 10.4 TNF IFNB1
4 fungal keratitis 10.4 TLR4 CD209
5 fanconi anemia, complementation group a 10.4
6 adult dermatomyositis 10.4 TNF GPT
7 hepatoportal sclerosis 10.4 GPT F2
8 granulocytopenia 10.4 TNF NQO2
9 penicilliosis 10.4 TNF TLR4
10 opisthorchiasis 10.4 TNF GPT
11 periodontosis 10.3 TNF TLR4
12 hepatic tuberculosis 10.3 GPT F2
13 ebola hemorrhagic fever 10.3
14 viral hemorrhagic fever 10.3
15 endometrial disease 10.3 TNF TLR4
16 kwashiorkor 10.3 GPT F2
17 measles 10.3 STAT2 IFNB1 CD209
18 japanese encephalitis 10.3 TNF IFNB1 CD209
19 hepatic coma 10.3 GPT F2
20 spondylarthropathy 10.3 TNF TLR4
21 severe acute respiratory syndrome 10.3 TNF IFNB1 CD209
22 trichosporonosis 10.3 TNF ICAM3
23 infantile liver failure syndrome 1 10.3 GPT F2
24 immune system disease 10.3 TNF IFNB1 CANX
25 hepatitis d 10.3 GPT F2
26 extrinsic cardiomyopathy 10.3 TNF TLR4 IFNB1
27 headache 10.2
28 lymphadenitis 10.2 TNF TLR4 CD209
29 aspergillosis 10.2 TNF TLR4 CD209
30 actinic prurigo 10.2 TNF ICAM3
31 murray valley encephalitis 10.2 IFNB1 ERVW-1
32 fanconi anemia, complementation group d2 10.2
33 dementia 10.2
34 stenotrophomonas maltophilia infection 10.2
35 lassa fever 10.2
36 compartment syndrome 10.2 TNF F2
37 mycobacterium tuberculosis 1 10.2 TNF TLR4 CD209
38 alveolar echinococcosis 10.2 TNF TLR4
39 typhoid fever 10.2 TNF TLR4 F2
40 scrub typhus 10.1 TNF TLR4 GPT
41 inflammatory bowel disease 6 10.1 TLR4 CD209
42 hepatitis 10.1 TNF GPT F2
43 hepatitis e 10.1 TNF GPT F2
44 gastrointestinal system disease 10.1 TNF TLR4 F2
45 cerebrovascular disease 10.1 TNF TLR4 F2
46 obstructive jaundice 10.1 TNF GPT F2
47 hepatic encephalopathy 10.1 TNF GPT F2
48 alcoholic hepatitis 10.1 TNF GPT F2
49 portal hypertension 10.1 TNF GPT F2
50 cholangitis 10.1 TNF GPT F2

Graphical network of the top 20 diseases related to Marburg Hemorrhagic Fever:



Diseases related to Marburg Hemorrhagic Fever

Symptoms & Phenotypes for Marburg Hemorrhagic Fever

Human phenotypes related to Marburg Hemorrhagic Fever:

59 32 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
3 menometrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0400008
4 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
5 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
6 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
7 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
8 hematuria 59 32 frequent (33%) Frequent (79-30%) HP:0000790
9 gastrointestinal hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0002239
10 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
11 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
12 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
13 elevated hepatic transaminase 59 32 frequent (33%) Frequent (79-30%) HP:0002910
14 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
15 jaundice 59 32 frequent (33%) Frequent (79-30%) HP:0000952
16 pancreatitis 59 32 frequent (33%) Frequent (79-30%) HP:0001733
17 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
18 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
19 recurrent pharyngitis 59 32 frequent (33%) Frequent (79-30%) HP:0100776
20 leukopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001882
21 subconjunctival hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0011896
22 skin rash 59 32 occasional (7.5%) Occasional (29-5%) HP:0000988
23 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
24 abnormal bleeding 59 Occasional (29-5%)

Symptoms:

12 (show all 12)
  • fever
  • vomiting
  • abdominal pain
  • myalgia
  • chest pain
  • headache
  • diarrhea
  • nausea
  • chills
  • sore throat
  • bleeding
  • maculopapular rash on the trunk

Drugs & Therapeutics for Marburg Hemorrhagic Fever

Drugs for Marburg Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1
2 Vaccines Phase 1
3 Immunologic Factors Phase 1
4 polysaccharide-K Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Dose-Escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-6003 in Healthy Adult Volunteers Completed NCT01353040 Phase 1 AVI-6003;Placebo
2 A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Dose-Escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers Completed NCT01566877 Phase 1 AVI-7288
3 A Phase I Trial to Utilize Systems Biology Approaches to Examine the Safety, Immunogenicity, and 'Omics Response to MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Completed NCT02891980 Phase 1
4 A Phase IB Study to Evaluate the Safety and Immunogenicity of an Ebola DNA Plasmid Vaccine, VRC-EBODNA023-00-VP, and a Marburg DNA Plasmid Vaccine, VRC-MARDNA025-00-VP, in Healthy Adults in Kampala, Uganda Completed NCT00997607 Phase 1
5 VRC 206: A Phase I Study to Evaluate the Safety and Immunogenicity of an Ebola DNA Plasmid Vaccine, VRC-EBODNA023-00-VP, and a Marburg DNA Plasmid Vaccine, VRC-MARDNA025-00-VP, in Healthy Adults Completed NCT00605514 Phase 1 VRC-EBODNA023-00-VP;VRC-MARDNA025-00-VP
6 A Phase 1 Double-blind, Placebo Controlled, Dose Ranging Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Galidesivir (BCX4430) Administered as Single Doses Via Intravenous Infusion in Healthy Subjects Recruiting NCT03800173 Phase 1 galidesivir;placebo
7 RV 507: A Phase I Open-Label, Dose-Escalation Clinical Trial to Evaluate the Safety, Tolerability and Immunogenicity of the Marburg Chimpanzee Adenovirus Vector Vaccine, VRC-MARADC087-00-VP (cAd3-Marburg), in Healthy Adults Active, not recruiting NCT03475056 Phase 1

Search NIH Clinical Center for Marburg Hemorrhagic Fever

Cochrane evidence based reviews: marburg virus disease

Genetic Tests for Marburg Hemorrhagic Fever

Anatomical Context for Marburg Hemorrhagic Fever

MalaCards organs/tissues related to Marburg Hemorrhagic Fever:

41
Skin, Testes, B Cells

Publications for Marburg Hemorrhagic Fever

Articles related to Marburg Hemorrhagic Fever:

(show top 50) (show all 128)
# Title Authors PMID Year
1
Marburgvirus in Egyptian Fruit Bats, Zambia. 38
31146800 2019
2
Marburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findings. 38
30883555 2019
3
Clinical, Histopathologic, and Immunohistochemical Characterization of Experimental Marburg Virus Infection in A Natural Reservoir Host, the Egyptian Rousette Bat (Rousettus aegyptiacus). 38
30832364 2019
4
A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine Model. 38
30567978 2019
5
Lowland grazing and Marburg virus disease (MVD) outbreak in Kween district, Eastern Uganda. 38
30704427 2019
6
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. 38
29982632 2018
7
Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters. 38
30192975 2018
8
Monoclonal Antibody Cocktail Protects Hamsters From Lethal Marburg Virus Infection. 38
29889266 2018
9
The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts. 38
30261226 2018
10
Infection Rates and Risk Factors for Infection Among Health Workers During Ebola and Marburg Virus Outbreaks: A Systematic Review. 38
30202878 2018
11
New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. 38
30053050 2018
12
Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease. 38
30285648 2018
13
Small Animal Models for Evaluating Filovirus Countermeasures. 38
29457711 2018
14
Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis. 38
29031848 2017
15
N-Heterocyclic borneol derivatives as inhibitors of Marburg virus glycoprotein-mediated VSIV pseudotype entry. 38
30108738 2017
16
Ecological Niche Modeling for Filoviruses: A Risk Map for Ebola and Marburg Virus Disease Outbreaks in Uganda. 38
29034123 2017
17
Knowledge and attitude towards Ebola and Marburg virus diseases in Uganda using quantitative and participatory epidemiology techniques. 38
28892520 2017
18
Isolated Case of Marburg Virus Disease, Kampala, Uganda, 2014. 38
28518032 2017
19
Filoviruses and bats. 38
28603449 2017
20
Filovirus Research: How it Began. 38
28766193 2017
21
A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever. 38
27976688 2016
22
Notes from the Field: Rift Valley Fever Response - Kabale District, Uganda, March 2016. 38
27811840 2016
23
How severe and prevalent are Ebola and Marburg viruses? A systematic review and meta-analysis of the case fatality rates and seroprevalence. 38
27887599 2016
24
Polio infrastructure strengthened disease outbreak preparedness and response in the WHO African Region. 38
27378681 2016
25
Ebola virus disease candidate vaccines under evaluation in clinical trials. 38
27160784 2016
26
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. 38
26589246 2016
27
Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012. 38
26209681 2015
28
Comparison of the Pathogenesis of the Angola and Ravn Strains of Marburg Virus in the Outbred Guinea Pig Model. 38
26092858 2015
29
Mapping the zoonotic niche of Marburg virus disease in Africa. 38
25820266 2015
30
A Comparison of the Pathogenesis of Marburg Virus Disease in Humans and Nonhuman Primates and Evaluation of the Suitability of These Animal Models for Predicting Clinical Efficacy under the 'Animal Rule'. 38
26141449 2015
31
Oral shedding of Marburg virus in experimentally infected Egyptian fruit bats (Rousettus aegyptiacus). 38
25375951 2015
32
Calculation of incubation period and serial interval from multiple outbreaks of Marburg virus disease. 38
25495697 2014
33
Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus. 38
25142608 2014
34
Diagnostic schemes for reducing epidemic size of African viral hemorrhagic fever outbreaks. 38
25212079 2014
35
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. 38
24590073 2014
36
Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences. 38
24556792 2014
37
Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. 38
23255566 2013
38
Forty-five years of Marburg virus research. 38
23202446 2012
39
A review of filovirus work and facilities at the Defence Science and Technology Laboratory Porton Down. 38
23012627 2012
40
Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever. 38
22710186 2012
41
Ebola and Marburg hemorrhagic fevers: neglected tropical diseases? 38
22761967 2012
42
Advanced morpholino oligomers: a novel approach to antiviral therapy. 38
22353544 2012
43
Infection control during filoviral hemorrhagic Fever outbreaks. 38
22529631 2012
44
[Filoviruses]. 38
24153230 2012
45
Transmission potential and design of adequate control measures for Marburg hemorrhagic fever. 38
23251407 2012
46
Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection. 38
23055920 2012
47
Pathogenesis of Marburg hemorrhagic fever in cynomolgus macaques. 38
21987738 2011
48
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. 38
21987753 2011
49
Clinical aspects of Marburg hemorrhagic fever. 38
22046196 2011
50
The use of a mobile laboratory unit in support of patient management and epidemiological surveillance during the 2005 Marburg Outbreak in Angola. 38
21629730 2011

Variations for Marburg Hemorrhagic Fever

Expression for Marburg Hemorrhagic Fever

Search GEO for disease gene expression data for Marburg Hemorrhagic Fever.

Pathways for Marburg Hemorrhagic Fever

Pathways related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 TNF TLR4 IFNB1
2
Show member pathways
11.91 TNF STAT2 CD209
3
Show member pathways
11.87 TNF TLR4 IFNB1
4 11.79 TLR4 CD209 CANX
5
Show member pathways
11.66 TNF TLR4 STAT2
6 11.6 TNF STAT2 IFNB1
7
Show member pathways
11.53 TNF TLR4 F2
8 11.51 TNF TLR4 IFNB1 CD209
9 11.2 TNF IFNB1 CD209
10
Show member pathways
11.16 TNF TLR4 STAT2 IFNB1
11 10.97 TNF IFNB1
12 10.84 TNF IFNB1
13 10.75 ICAM3 CD209

GO Terms for Marburg Hemorrhagic Fever

Cellular components related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 TNF TLR4 F2 CD209

Biological processes related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of interleukin-6 production GO:0032715 9.26 TNF TLR4
2 positive regulation of interleukin-8 production GO:0032757 9.16 TNF TLR4
3 positive regulation of chemokine production GO:0032722 8.96 TNF TLR4
4 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.62 TNF TLR4

Sources for Marburg Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....