MCID: MRB001
MIFTS: 43

Marburg Hemorrhagic Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Marburg Hemorrhagic Fever

MalaCards integrated aliases for Marburg Hemorrhagic Fever:

Name: Marburg Hemorrhagic Fever 12 53 59 3 15
Marburg Virus Disease 12 53 59 44 73
Marburg Disease 12 53
Green Monkey Disease 59
Mhf 59

Characteristics:

Orphanet epidemiological data:

59
marburg hemorrhagic fever
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Marburg Hemorrhagic Fever

CDC : 3 Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). Thirty-one people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them. Seven deaths were reported. The first people infected had been exposed to imported African green monkeys or their tissues while conducting research. One additional case was diagnosed retrospectively.

MalaCards based summary : Marburg Hemorrhagic Fever, also known as marburg virus disease, is related to hemorrhagic fever and listeria meningitis, and has symptoms including fever, chills and headache. An important gene associated with Marburg Hemorrhagic Fever is NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2), and among its related pathways/superpathways are Influenza A and Tuberculosis. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are hematuria and jaundice

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Marburgvirus, which is transmitted by contact with the body fluids of an infected person. The infection has symptom fever, has symptom chills, has symptom headache, has symptom myalgia, has symptom maculopapular rash on the trunk, has symptom nausea, has symptom vomiting, has symptom chest pain, has symptom sore throat, has symptom abdominal pain, has symptom diarrhea, and has symptom bleeding.

Wikipedia : 76 Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a severe illness of humans and... more...

Related Diseases for Marburg Hemorrhagic Fever

Diseases related to Marburg Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 30.3 CD209 F2 TNF
2 listeria meningitis 10.3 IFNB1 TNF
3 extrinsic cardiomyopathy 10.3 IFNB1 TNF
4 primary progressive multiple sclerosis 10.3 IFNB1 TNF
5 leprosy 3 10.2 CD209 TNF
6 trichosporonosis 10.2 ICAM3 TNF
7 actinic prurigo 10.2 ICAM3 TNF
8 lymphadenitis 10.2 CD209 TNF
9 nonalcoholic steatohepatitis 10.1 F2 TNF
10 ischemic heart disease 10.1 F2 TNF
11 relapsing-remitting multiple sclerosis 10.1 IFNB1 TNF
12 compartment syndrome 10.1 F2 TNF
13 spotted fever 10.1 F2 TNF
14 hepatitis e 10.1 F2 TNF
15 severe hemophilia a 10.1 F2 TNF
16 infective endocarditis 10.1 F2 TNF
17 intracranial hypertension 10.0 F2 TNF
18 leptospirosis 10.0 F2 TNF
19 hepatitis a 10.0 F2 TNF
20 typhoid fever 10.0 F2 TNF
21 adult respiratory distress syndrome 10.0 F2 TNF
22 obstructive jaundice 10.0 F2 TNF
23 pulmonary edema 10.0 F2 TNF
24 hepatic encephalopathy 10.0 F2 TNF
25 endocarditis 10.0 F2 TNF
26 alcoholic hepatitis 10.0 F2 TNF
27 sickle cell anemia 9.9 F2 TNF
28 portal hypertension 9.9 F2 TNF
29 schistosomiasis 9.9 F2 TNF
30 purpura 9.9 F2 TNF
31 cerebral palsy 9.9 F2 TNF
32 peritonitis 9.9 F2 TNF
33 cholangitis 9.8 F2 TNF
34 japanese encephalitis 9.8 CD209 IFNB1 TNF
35 severe acute respiratory syndrome 9.8 CD209 IFNB1 TNF
36 viral infectious disease 9.8 CD209 IFNB1 TNF
37 eclampsia 9.8 F2 TNF
38 viral hepatitis 9.8 F2 TNF
39 lassa fever 9.8
40 arteries, anomalies of 9.7 F2 TNF
41 immune system disease 9.7 F2 TNF
42 gastrointestinal system cancer 9.6 F2 TNF
43 dengue hemorrhagic fever 9.6 CD209 F2 TNF
44 demyelinating disease 9.5 IFNB1 TNF
45 gastrointestinal system disease 9.5 F2 TNF

Graphical network of the top 20 diseases related to Marburg Hemorrhagic Fever:



Diseases related to Marburg Hemorrhagic Fever

Symptoms & Phenotypes for Marburg Hemorrhagic Fever

Symptoms:

12 (show all 12)
  • fever
  • chills
  • headache
  • myalgia
  • maculopapular rash on the trunk
  • nausea
  • vomiting
  • chest pain
  • sore throat
  • abdominal pain
  • diarrhea
  • bleeding

Human phenotypes related to Marburg Hemorrhagic Fever:

59 32 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematuria 59 32 frequent (33%) Frequent (79-30%) HP:0000790
2 jaundice 59 32 frequent (33%) Frequent (79-30%) HP:0000952
3 skin rash 59 32 occasional (7.5%) Occasional (29-5%) HP:0000988
4 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
5 pancreatitis 59 32 frequent (33%) Frequent (79-30%) HP:0001733
6 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
7 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
8 leukopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001882
9 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
10 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
11 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
12 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
13 gastrointestinal hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0002239
14 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
15 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
16 elevated hepatic transaminases 59 32 frequent (33%) Frequent (79-30%) HP:0002910
17 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
18 subconjunctival hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0011896
19 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
20 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
21 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
22 recurrent pharyngitis 59 32 frequent (33%) Frequent (79-30%) HP:0100776
23 menometrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0400008
24 abnormal bleeding 59 Occasional (29-5%)

Drugs & Therapeutics for Marburg Hemorrhagic Fever

Drugs for Marburg Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1
2 Pharmaceutical Solutions Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers Completed NCT01566877 Phase 1 AVI-7288
2 Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus Completed NCT01353040 Phase 1 AVI-6003;Placebo
3 Ebola and Marburg Virus Vaccines Completed NCT00605514 Phase 1 VRC-EBODNA023-00-VP;VRC-MARDNA025-00-VP
4 Evaluating an Ebola and a Marburg Vaccine in Uganda Completed NCT00997607 Phase 1
5 MVA-BN®-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Active, not recruiting NCT02891980 Phase 1
6 cAd3-Marburg Vaccine in Healthy Adults Not yet recruiting NCT03475056 Phase 1

Search NIH Clinical Center for Marburg Hemorrhagic Fever

Cochrane evidence based reviews: marburg virus disease

Genetic Tests for Marburg Hemorrhagic Fever

Anatomical Context for Marburg Hemorrhagic Fever

MalaCards organs/tissues related to Marburg Hemorrhagic Fever:

41
Skin

Publications for Marburg Hemorrhagic Fever

Articles related to Marburg Hemorrhagic Fever:

(show all 29)
# Title Authors Year
1
A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever. ( 27976688 )
2016
2
Marburg hemorrhagic fever in returning travellers: an overview aimed at clinicians. ( 24816494 )
2014
3
Interferon-I^ therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. ( 23255566 )
2013
4
Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever. ( 22710186 )
2012
5
Transmission potential and design of adequate control measures for Marburg hemorrhagic fever. ( 23251407 )
2012
6
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. ( 21987753 )
2011
7
Clinical aspects of Marburg hemorrhagic fever. ( 22046196 )
2011
8
Pathogenesis of Marburg hemorrhagic fever in cynomolgus macaques. ( 21987738 )
2011
9
Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. ( 20441515 )
2010
10
Ebola and marburg hemorrhagic fever. ( 20513546 )
2010
11
Development and characterization of a mouse model for Marburg hemorrhagic fever. ( 19369350 )
2009
12
Imported case of Marburg hemorrhagic fever - Colorado, 2008. ( 20019654 )
2009
13
Response to imported case of Marburg hemorrhagic fever, the Netherland. ( 19751577 )
2009
14
The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. I. Lessons learned in the hospital. ( 17940944 )
2007
15
Development of vaccines for Marburg hemorrhagic fever. ( 17280479 )
2007
16
Use of protective gear and the occurrence of occupational Marburg hemorrhagic fever in health workers from Watsa health zone, Democratic Republic of the Congo. ( 17940946 )
2007
17
Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment. ( 17940943 )
2007
18
The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. II. lessons learned in the community. ( 17940945 )
2007
19
Serosurvey on household contacts of Marburg hemorrhagic fever patients. ( 16704781 )
2006
20
Geographic potential for outbreaks of Marburg hemorrhagic fever. ( 16837700 )
2006
21
Marburg hemorrhagic fever--the forgotten cousin strikes. ( 16943398 )
2006
22
Marburg hemorrhagic fever associated with multiple genetic lineages of virus. ( 16943403 )
2006
23
Laboratory diagnosis of Ebola and Marburg hemorrhagic fever. ( 16267962 )
2005
24
Outbreak of Marburg hemorrhagic fever in Angola: a review of the history of the disease and its biological aspects. ( 16044395 )
2005
25
Marburg hemorrhagic fever in Angola--fighting fear and a lethal pathogen. ( 15917379 )
2005
26
Other viral bioweapons: Ebola and Marburg hemorrhagic fever. ( 15207310 )
2004
27
Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. ( 14720391 )
2003
28
The use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys. ( 11687854 )
2001
29
Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy. ( 9491211 )
1998

Variations for Marburg Hemorrhagic Fever

Expression for Marburg Hemorrhagic Fever

Search GEO for disease gene expression data for Marburg Hemorrhagic Fever.

Pathways for Marburg Hemorrhagic Fever

Pathways related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 CD209 IFNB1 TNF
2 11.38 CD209 IFNB1 TNF
3 10.8 IFNB1 TNF
4 10.67 CD209 IFNB1 TNF
5 10.64 IFNB1 TNF
6 10.5 CD209 ICAM3

GO Terms for Marburg Hemorrhagic Fever

Cellular components related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 ADIRF CD209 F2 ICAM3 NQO2
2 external side of plasma membrane GO:0009897 8.8 CD209 F2 TNF

Biological processes related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.33 F2 IFNB1 TNF
2 humoral immune response GO:0006959 8.96 IFNB1 TNF
3 negative regulation of viral genome replication GO:0045071 8.62 IFNB1 TNF

Sources for Marburg Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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