MHF
MCID: MRB001
MIFTS: 48

Marburg Hemorrhagic Fever (MHF)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Marburg Hemorrhagic Fever

MalaCards integrated aliases for Marburg Hemorrhagic Fever:

Name: Marburg Hemorrhagic Fever 12 53 59 3 15
Marburg Virus Disease 12 53 59 44 73
Marburg Disease 12 53
Green Monkey Disease 59
Mhf 59

Characteristics:

Orphanet epidemiological data:

59
marburg hemorrhagic fever
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Marburg Hemorrhagic Fever

CDC : 3 Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). Thirty-one people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them. Seven deaths were reported. The first people infected had been exposed to imported African green monkeys or their tissues while conducting research. One additional case was diagnosed retrospectively.

MalaCards based summary : Marburg Hemorrhagic Fever, also known as marburg virus disease, is related to hemorrhagic fever and viral infectious disease, and has symptoms including fever, vomiting and abdominal pain. An important gene associated with Marburg Hemorrhagic Fever is NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2), and among its related pathways/superpathways are Influenza A and Epstein-Barr virus infection. The drugs Pharmaceutical Solutions and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related phenotypes are nausea and vomiting and fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Marburgvirus, which is transmitted by contact with the body fluids of an infected person. The infection has symptom fever, has symptom chills, has symptom headache, has symptom myalgia, has symptom maculopapular rash on the trunk, has symptom nausea, has symptom vomiting, has symptom chest pain, has symptom sore throat, has symptom abdominal pain, has symptom diarrhea, and has symptom bleeding.

Wikipedia : 76 Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a severe illness of humans and... more...

Related Diseases for Marburg Hemorrhagic Fever

Diseases related to Marburg Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 31.0 CD209 F2 TNF
2 viral infectious disease 30.0 CD209 IFNB1 TNF
3 microphthalmia with limb anomalies 10.2 IFNB1 STAT2
4 granulocytopenia 10.1 NQO2 TNF
5 listeria meningitis 10.1 IFNB1 TNF
6 dengue virus 10.1 CD209 STAT2
7 avian influenza 10.1 STAT2 TNF
8 newcastle disease 10.1 IFNB1 TNF
9 spinal cord disease 10.1 IFNB1 TNF
10 extrinsic cardiomyopathy 10.1 IFNB1 TNF
11 mumps 10.1 STAT2 TNF
12 primary progressive multiple sclerosis 10.1 IFNB1 TNF
13 noonan syndrome 3 10.1 IFNB1 STAT2
14 autoimmune disease of central nervous system 10.1 IFNB1 TNF
15 trichosporonosis 10.1 ICAM3 TNF
16 actinic prurigo 10.1 ICAM3 TNF
17 autoimmune disease of the nervous system 10.1 IFNB1 TNF
18 leprosy 3 10.1 CD209 TNF
19 lymphadenitis 10.0 CD209 TNF
20 vascular hemostatic disease 10.0 F2 TNF
21 nonalcoholic steatohepatitis 10.0 F2 TNF
22 aspergillosis 10.0 CD209 TNF
23 compartment syndrome 10.0 F2 TNF
24 spotted fever 10.0 F2 TNF
25 infective endocarditis 10.0 F2 TNF
26 endocarditis 10.0 F2 TNF
27 hepatitis e 10.0 F2 TNF
28 intracranial hypertension 10.0 F2 TNF
29 leptospirosis 10.0 F2 TNF
30 hepatitis a 10.0 F2 TNF
31 typhoid fever 10.0 F2 TNF
32 adult respiratory distress syndrome 10.0 F2 TNF
33 measles 10.0 CD209 IFNB1 STAT2
34 obstructive jaundice 10.0 F2 TNF
35 pulmonary edema 10.0 F2 TNF
36 hepatic encephalopathy 10.0 F2 TNF
37 alcoholic hepatitis 10.0 F2 TNF
38 sickle cell anemia 10.0 F2 TNF
39 relapsing-remitting multiple sclerosis 10.0 IFNB1 TNF
40 noonan syndrome 1 10.0 IFNB1 STAT2 TNF
41 portal hypertension 10.0 F2 TNF
42 schistosomiasis 9.9 F2 TNF
43 japanese encephalitis 9.9 CD209 IFNB1 TNF
44 severe acute respiratory syndrome 9.9 CD209 IFNB1 TNF
45 purpura 9.9 F2 TNF
46 cholangitis 9.9 F2 TNF
47 peritonitis 9.9 F2 TNF
48 cerebral palsy 9.9 F2 TNF
49 ebola hemorrhagic fever 9.9
50 lassa fever 9.9

Graphical network of the top 20 diseases related to Marburg Hemorrhagic Fever:



Diseases related to Marburg Hemorrhagic Fever

Symptoms & Phenotypes for Marburg Hemorrhagic Fever

Symptoms:

12 (show all 12)
  • fever
  • vomiting
  • abdominal pain
  • myalgia
  • chest pain
  • diarrhea
  • headache
  • nausea
  • chills
  • bleeding
  • sore throat
  • maculopapular rash on the trunk

Human phenotypes related to Marburg Hemorrhagic Fever:

59 32 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
2 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
3 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
4 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
5 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
6 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
7 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
8 jaundice 59 32 frequent (33%) Frequent (79-30%) HP:0000952
9 pancreatitis 59 32 frequent (33%) Frequent (79-30%) HP:0001733
10 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
11 hematuria 59 32 frequent (33%) Frequent (79-30%) HP:0000790
12 gastrointestinal hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0002239
13 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
14 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
15 recurrent pharyngitis 59 32 frequent (33%) Frequent (79-30%) HP:0100776
16 skin rash 59 32 occasional (7.5%) Occasional (29-5%) HP:0000988
17 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
18 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
19 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
20 leukopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001882
21 menometrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0400008
22 subconjunctival hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0011896
23 abnormal bleeding 59 Occasional (29-5%)
24 elevated hepatic transaminases 59 Frequent (79-30%)
25 elevated hepatic transaminase 32 frequent (33%) HP:0002910

Drugs & Therapeutics for Marburg Hemorrhagic Fever

Drugs for Marburg Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1
2 Vaccines Phase 1
3 Immunologic Factors Phase 1
4 Krestin Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers Completed NCT01566877 Phase 1 AVI-7288
2 Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus Completed NCT01353040 Phase 1 AVI-6003;Placebo
3 Ebola and Marburg Virus Vaccines Completed NCT00605514 Phase 1 VRC-EBODNA023-00-VP;VRC-MARDNA025-00-VP
4 Evaluating an Ebola and a Marburg Vaccine in Uganda Completed NCT00997607 Phase 1
5 A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430 Recruiting NCT03800173 Phase 1 galidesivir;placebo
6 cAd3-Marburg Vaccine in Healthy Adults Recruiting NCT03475056 Phase 1
7 A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Active, not recruiting NCT02891980 Phase 1

Search NIH Clinical Center for Marburg Hemorrhagic Fever

Cochrane evidence based reviews: marburg virus disease

Genetic Tests for Marburg Hemorrhagic Fever

Anatomical Context for Marburg Hemorrhagic Fever

MalaCards organs/tissues related to Marburg Hemorrhagic Fever:

41
Skin, Liver, Spinal Cord, Testes, B Cells

Publications for Marburg Hemorrhagic Fever

Articles related to Marburg Hemorrhagic Fever:

(show top 50) (show all 55)
# Title Authors Year
1
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. ( 29982632 )
2018
2
New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. ( 30053050 )
2018
3
Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease. ( 30285648 )
2018
4
Isolated Case of Marburg Virus Disease, Kampala, Uganda, 2014. ( 28518032 )
2017
5
Ecological Niche Modeling for Filoviruses: A Risk Map for Ebola and Marburg Virus Disease Outbreaks in Uganda. ( 29034123 )
2017
6
A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever. ( 27976688 )
2016
7
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. ( 26589246 )
2016
8
Mapping the zoonotic niche of Marburg virus disease in Africa. ( 25820266 )
2015
9
A Comparison of the Pathogenesis of Marburg Virus Disease in Humans and Nonhuman Primates and Evaluation of the Suitability of These Animal Models for Predicting Clinical Efficacy under the 'Animal Rule'. ( 26141449 )
2015
10
Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012. ( 26209681 )
2015
11
Marburg hemorrhagic fever in returning travellers: an overview aimed at clinicians. ( 24816494 )
2014
12
Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences. ( 24556792 )
2014
13
Calculation of incubation period and serial interval from multiple outbreaks of Marburg virus disease. ( 25495697 )
2014
14
Interferon-I^ therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. ( 23255566 )
2013
15
Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever. ( 22710186 )
2012
16
Transmission potential and design of adequate control measures for Marburg hemorrhagic fever. ( 23251407 )
2012
17
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. ( 21987753 )
2011
18
Clinical aspects of Marburg hemorrhagic fever. ( 22046196 )
2011
19
Pathogenesis of Marburg hemorrhagic fever in cynomolgus macaques. ( 21987738 )
2011
20
Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. ( 20441515 )
2010
21
Ebola and marburg hemorrhagic fever. ( 20513546 )
2010
22
Development and characterization of a mouse model for Marburg hemorrhagic fever. ( 19369350 )
2009
23
Imported case of Marburg hemorrhagic fever - Colorado, 2008. ( 20019654 )
2009
24
Response to imported case of Marburg hemorrhagic fever, the Netherland. ( 19751577 )
2009
25
The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. I. Lessons learned in the hospital. ( 17940944 )
2007
26
Development of vaccines for Marburg hemorrhagic fever. ( 17280479 )
2007
27
Use of protective gear and the occurrence of occupational Marburg hemorrhagic fever in health workers from Watsa health zone, Democratic Republic of the Congo. ( 17940946 )
2007
28
Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment. ( 17940943 )
2007
29
The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. II. lessons learned in the community. ( 17940945 )
2007
30
Serosurvey on household contacts of Marburg hemorrhagic fever patients. ( 16704781 )
2006
31
Geographic potential for outbreaks of Marburg hemorrhagic fever. ( 16837700 )
2006
32
Marburg hemorrhagic fever--the forgotten cousin strikes. ( 16943398 )
2006
33
Marburg hemorrhagic fever associated with multiple genetic lineages of virus. ( 16943403 )
2006
34
Laboratory diagnosis of Ebola and Marburg hemorrhagic fever. ( 16267962 )
2005
35
Outbreak of Marburg hemorrhagic fever in Angola: a review of the history of the disease and its biological aspects. ( 16044395 )
2005
36
Marburg hemorrhagic fever in Angola--fighting fear and a lethal pathogen. ( 15917379 )
2005
37
Marburg virus disease, Angola. ( 15875654 )
2005
38
Other viral bioweapons: Ebola and Marburg hemorrhagic fever. ( 15207310 )
2004
39
Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. ( 14720391 )
2003
40
Short communication: a cluster of Marburg virus disease involving an infant. ( 12358627 )
2002
41
The use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys. ( 11687854 )
2001
42
Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy. ( 9491211 )
1998
43
The pathology of Marburg virus disease. ( 6539950 )
1984
44
Marburg-virus disease in Kenya. ( 6122054 )
1982
45
Marburg virus disease--an indicator case in South Africa. ( 6890717 )
1982
46
Marburg virus disease. The diagnosis and management of suspected cases. ( 7029731 )
1981
47
Communicable diseases. 6. Marburg virus disease. ( 251839 )
1978
48
Early detection of antigen and estimation of virus yield in specimens from patients with Marburg virus disease. ( 310364 )
1978
49
Epidemiologic investigation of Marburg virus disease, Southern Africa, 1975. ( 569445 )
1978
50
Uveal involvement in Marburg virus disease. ( 557985 )
1977

Variations for Marburg Hemorrhagic Fever

Expression for Marburg Hemorrhagic Fever

Search GEO for disease gene expression data for Marburg Hemorrhagic Fever.

Pathways for Marburg Hemorrhagic Fever

GO Terms for Marburg Hemorrhagic Fever

Cellular components related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD209 F2 TNF

Biological processes related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.4 F2 TNF
2 type I interferon signaling pathway GO:0060337 9.37 IFNB1 STAT2
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.32 CD209 ICAM3
4 humoral immune response GO:0006959 9.26 IFNB1 TNF
5 regulation of protein phosphorylation GO:0001932 9.16 STAT2 TNF
6 cytokine-mediated signaling pathway GO:0019221 9.13 IFNB1 STAT2 TNF
7 negative regulation of viral genome replication GO:0045071 8.62 IFNB1 TNF

Sources for Marburg Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....