MCID: MRB001
MIFTS: 49

Marburg Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Marburg Hemorrhagic Fever

MalaCards integrated aliases for Marburg Hemorrhagic Fever:

Name: Marburg Hemorrhagic Fever 12 54 60 3 15 17
Marburg Virus Disease 12 54 60 45 74
Marburg Disease 12 54
Green Monkey Disease 60
Mhf 60

Characteristics:

Orphanet epidemiological data:

60
marburg hemorrhagic fever
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Marburg Hemorrhagic Fever

CDC : 3 Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). Thirty-one people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them. Seven deaths were reported. The first people infected had been exposed to imported African green monkeys or their tissues while conducting research. One additional case was diagnosed retrospectively.

MalaCards based summary : Marburg Hemorrhagic Fever, also known as marburg virus disease, is related to microphthalmia with limb anomalies and granulocytopenia, and has symptoms including fever, vomiting and abdominal pain. An important gene associated with Marburg Hemorrhagic Fever is NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and PI3K-Akt signaling pathway. The drugs Pharmaceutical Solutions and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and testes, and related phenotypes are fever and fatigue

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Marburgvirus, which is transmitted by contact with the body fluids of an infected person. The infection has symptom fever, has symptom chills, has symptom headache, has symptom myalgia, has symptom maculopapular rash on the trunk, has symptom nausea, has symptom vomiting, has symptom chest pain, has symptom sore throat, has symptom abdominal pain, has symptom diarrhea, and has symptom bleeding.

Wikipedia : 77 Marburg virus disease (MVD; formerly Marburg hemorrhagic fever) is a severe illness of humans and... more...

Related Diseases for Marburg Hemorrhagic Fever

Diseases related to Marburg Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 microphthalmia with limb anomalies 10.3 IFNB1 STAT2
2 granulocytopenia 10.3 NQO2 TNF
3 listeria meningitis 10.3 IFNB1 TNF
4 fungal keratitis 10.2 CD209 TLR4
5 spinal cord disease 10.2 IFNB1 TNF
6 trench fever 10.2 TLR4 TNF
7 inflammatory bowel disease 6 10.2 CD209 TLR4
8 penicilliosis 10.2 TLR4 TNF
9 endometrial disease 10.2 TLR4 TNF
10 periodontosis 10.2 TLR4 TNF
11 spondylarthropathy 10.2 TLR4 TNF
12 trichosporonosis 10.2 ICAM3 TNF
13 alveolar echinococcosis 10.2 TLR4 TNF
14 stenotrophomonas maltophilia infection 10.2
15 echinococcosis 10.2 TLR4 TNF
16 actinic prurigo 10.2 ICAM3 TNF
17 vascular hemostatic disease 10.2 F2 TNF
18 middle ear disease 10.1 TLR4 TNF
19 bacterial sepsis 10.1 TLR4 TNF
20 compartment syndrome 10.1 F2 TNF
21 ileitis 10.1 TLR4 TNF
22 spotted fever 10.1 F2 TNF
23 perinatal necrotizing enterocolitis 10.1 TLR4 TNF
24 measles 10.1 CD209 IFNB1 STAT2
25 adult dermatomyositis 10.1 GPT TNF
26 q fever 10.1 TLR4 TNF
27 opisthorchiasis 10.1 GPT TNF
28 idiopathic neutropenia 10.1 TLR4 TNF
29 primary progressive multiple sclerosis 10.1 IFNB1 TNF
30 japanese encephalitis 10.1 CD209 IFNB1 TNF
31 paracoccidioidomycosis 10.1 TLR4 TNF
32 severe acute respiratory syndrome 10.1 CD209 IFNB1 TNF
33 bacterial vaginosis 10.1 TLR4 TNF
34 infective endocarditis 10.1 F2 TNF
35 hepatoportal sclerosis 10.1 F2 GPT
36 hepatic tuberculosis 10.0 F2 GPT
37 kwashiorkor 10.0 F2 GPT
38 hepatic coma 10.0 F2 GPT
39 infantile liver failure syndrome 1 10.0 F2 GPT
40 melioidosis 10.0 TLR4 TNF
41 hepatitis d 10.0 F2 GPT
42 extrinsic cardiomyopathy 10.0 IFNB1 TLR4 TNF
43 intracranial hypertension 10.0 F2 TNF
44 protein-energy malnutrition 10.0 GPT TNF
45 lymphadenitis 10.0 CD209 TLR4 TNF
46 aspergillosis 10.0 CD209 TLR4 TNF
47 choledocholithiasis 10.0 F2 GPT
48 mycobacterium tuberculosis 1 10.0 CD209 TLR4 TNF
49 analbuminemia 10.0 F2 GPT
50 noonan syndrome 1 10.0 IFNB1 STAT2 TNF

Graphical network of the top 20 diseases related to Marburg Hemorrhagic Fever:



Diseases related to Marburg Hemorrhagic Fever

Symptoms & Phenotypes for Marburg Hemorrhagic Fever

Human phenotypes related to Marburg Hemorrhagic Fever:

60 33 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
3 menometrorrhagia 60 33 hallmark (90%) Very frequent (99-80%) HP:0400008
4 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
5 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
6 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
7 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
8 elevated hepatic transaminase 60 33 frequent (33%) Frequent (79-30%) HP:0002910
9 thrombocytopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001873
10 jaundice 60 33 frequent (33%) Frequent (79-30%) HP:0000952
11 pancreatitis 60 33 frequent (33%) Frequent (79-30%) HP:0001733
12 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
13 hematuria 60 33 frequent (33%) Frequent (79-30%) HP:0000790
14 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
15 gastrointestinal hemorrhage 60 33 frequent (33%) Frequent (79-30%) HP:0002239
16 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
17 diarrhea 60 33 frequent (33%) Frequent (79-30%) HP:0002014
18 recurrent pharyngitis 60 33 frequent (33%) Frequent (79-30%) HP:0100776
19 cough 60 33 frequent (33%) Frequent (79-30%) HP:0012735
20 leukopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001882
21 subconjunctival hemorrhage 60 33 frequent (33%) Frequent (79-30%) HP:0011896
22 skin rash 60 33 occasional (7.5%) Occasional (29-5%) HP:0000988
23 lethargy 60 33 occasional (7.5%) Occasional (29-5%) HP:0001254
24 abnormal bleeding 60 Occasional (29-5%)

Symptoms:

12 (show all 12)
  • fever
  • vomiting
  • abdominal pain
  • myalgia
  • headache
  • chest pain
  • diarrhea
  • nausea
  • chills
  • sore throat
  • bleeding
  • maculopapular rash on the trunk

Drugs & Therapeutics for Marburg Hemorrhagic Fever

Drugs for Marburg Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1
2 Immunologic Factors Phase 1
3 Vaccines Phase 1
4 polysaccharide-K Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers Completed NCT01566877 Phase 1 AVI-7288
2 Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus Completed NCT01353040 Phase 1 AVI-6003;Placebo
3 A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Completed NCT02891980 Phase 1
4 Ebola and Marburg Virus Vaccines Completed NCT00605514 Phase 1 VRC-EBODNA023-00-VP;VRC-MARDNA025-00-VP
5 Evaluating an Ebola and a Marburg Vaccine in Uganda Completed NCT00997607 Phase 1
6 A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430 Recruiting NCT03800173 Phase 1 galidesivir;placebo
7 cAd3-Marburg Vaccine in Healthy Adults Recruiting NCT03475056 Phase 1

Search NIH Clinical Center for Marburg Hemorrhagic Fever

Cochrane evidence based reviews: marburg virus disease

Genetic Tests for Marburg Hemorrhagic Fever

Anatomical Context for Marburg Hemorrhagic Fever

MalaCards organs/tissues related to Marburg Hemorrhagic Fever:

42
Skin, Liver, Testes, B Cells, Spinal Cord

Publications for Marburg Hemorrhagic Fever

Articles related to Marburg Hemorrhagic Fever:

(show top 50) (show all 58)
# Title Authors Year
1
Lowland grazing and Marburg virus disease (MVD) outbreak in Kween district, Eastern Uganda. ( 30704427 )
2019
2
Marburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findings. ( 30883555 )
2019
3
A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein is Dependent Upon ADCC for Protection Against Marburg Virus Disease in a Murine Model. ( 30567978 )
2018
4
New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. ( 30053050 )
2018
5
Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease. ( 30285648 )
2018
6
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. ( 29982632 )
2018
7
Isolated Case of Marburg Virus Disease, Kampala, Uganda, 2014. ( 28518032 )
2017
8
Ecological Niche Modeling for Filoviruses: A Risk Map for Ebola and Marburg Virus Disease Outbreaks in Uganda. ( 29034123 )
2017
9
A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever. ( 27976688 )
2016
10
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. ( 26589246 )
2016
11
Mapping the zoonotic niche of Marburg virus disease in Africa. ( 25820266 )
2015
12
A Comparison of the Pathogenesis of Marburg Virus Disease in Humans and Nonhuman Primates and Evaluation of the Suitability of These Animal Models for Predicting Clinical Efficacy under the 'Animal Rule'. ( 26141449 )
2015
13
Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012. ( 26209681 )
2015
14
Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences. ( 24556792 )
2014
15
Calculation of incubation period and serial interval from multiple outbreaks of Marburg virus disease. ( 25495697 )
2014
16
Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. ( 23255566 )
2013
17
Retrospective evaluation of control measures for contacts of patient with Marburg hemorrhagic fever. ( 22710186 )
2012
18
Transmission potential and design of adequate control measures for Marburg hemorrhagic fever. ( 23251407 )
2012
19
Pathogenesis of Marburg hemorrhagic fever in cynomolgus macaques. ( 21987738 )
2011
20
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. ( 21987753 )
2011
21
Clinical aspects of Marburg hemorrhagic fever. ( 22046196 )
2011
22
Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. ( 20441515 )
2010
23
Ebola and marburg hemorrhagic fever. ( 20513546 )
2010
24
Development and characterization of a mouse model for Marburg hemorrhagic fever. ( 19369350 )
2009
25
Response to imported case of Marburg hemorrhagic fever, the Netherland. ( 19751577 )
2009
26
Imported case of Marburg hemorrhagic fever - Colorado, 2008. ( 20019654 )
2009
27
Development of vaccines for Marburg hemorrhagic fever. ( 17280479 )
2007
28
Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment. ( 17940943 )
2007
29
The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. I. Lessons learned in the hospital. ( 17940944 )
2007
30
The Medecins Sans Frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. II. lessons learned in the community. ( 17940945 )
2007
31
Use of protective gear and the occurrence of occupational Marburg hemorrhagic fever in health workers from Watsa health zone, Democratic Republic of the Congo. ( 17940946 )
2007
32
Serosurvey on household contacts of Marburg hemorrhagic fever patients. ( 16704781 )
2006
33
Geographic potential for outbreaks of Marburg hemorrhagic fever. ( 16837700 )
2006
34
Marburg hemorrhagic fever--the forgotten cousin strikes. ( 16943398 )
2006
35
Marburg hemorrhagic fever associated with multiple genetic lineages of virus. ( 16943403 )
2006
36
Marburg hemorrhagic fever in Angola--fighting fear and a lethal pathogen. ( 15917379 )
2005
37
Outbreak of Marburg hemorrhagic fever in Angola: a review of the history of the disease and its biological aspects. ( 16044395 )
2005
38
Laboratory diagnosis of Ebola and Marburg hemorrhagic fever. ( 16267962 )
2005
39
Marburg virus disease, Angola. ( 15875654 )
2005
40
Other viral bioweapons: Ebola and Marburg hemorrhagic fever. ( 15207310 )
2004
41
Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. ( 14720391 )
2003
42
Short communication: a cluster of Marburg virus disease involving an infant. ( 12358627 )
2002
43
The use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys. ( 11687854 )
2001
44
Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy. ( 9491211 )
1998
45
The pathology of Marburg virus disease. ( 6539950 )
1984
46
Marburg-virus disease in Kenya. ( 6122054 )
1982
47
Marburg virus disease--an indicator case in South Africa. ( 6890717 )
1982
48
Marburg virus disease. The diagnosis and management of suspected cases. ( 7029731 )
1981
49
Communicable diseases. 6. Marburg virus disease. ( 251839 )
1978
50
Early detection of antigen and estimation of virus yield in specimens from patients with Marburg virus disease. ( 310364 )
1978

Variations for Marburg Hemorrhagic Fever

Expression for Marburg Hemorrhagic Fever

Search GEO for disease gene expression data for Marburg Hemorrhagic Fever.

Pathways for Marburg Hemorrhagic Fever

Pathways related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 IFNB1 STAT2 TLR4 TNF
2
Show member pathways
12.68 IFNB1 STAT2 TLR4 TNF
3
Show member pathways
12.66 IFNB1 STAT2 TLR4 TNF
4
Show member pathways
11.95 IFNB1 TLR4 TNF
5
Show member pathways
11.87 CD209 STAT2 TNF
6
Show member pathways
11.8 IFNB1 TLR4 TNF
7
Show member pathways
11.66 STAT2 TLR4 TNF
8 11.6 IFNB1 STAT2 TNF
9
Show member pathways
11.53 F2 TLR4 TNF
10 11.51 CD209 IFNB1 TLR4 TNF
11 11.26 TLR4 TNF
12 11.2 CD209 IFNB1 TNF
13
Show member pathways
11.16 IFNB1 STAT2 TLR4 TNF
14 11.1 IFNB1 STAT2
15 11.07 TLR4 TNF
16 10.97 IFNB1 TNF
17 10.86 IFNB1 TNF
18 10.78 CD209 ICAM3

GO Terms for Marburg Hemorrhagic Fever

Cellular components related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD209 F2 TLR4 TNF

Biological processes related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-gamma production GO:0032729 9.43 TLR4 TNF
2 positive regulation of nitric oxide biosynthetic process GO:0045429 9.4 TLR4 TNF
3 negative regulation of viral genome replication GO:0045071 9.37 IFNB1 TNF
4 lipopolysaccharide-mediated signaling pathway GO:0031663 9.32 TLR4 TNF
5 negative regulation of interleukin-6 production GO:0032715 9.26 TLR4 TNF
6 positive regulation of interleukin-8 production GO:0032757 9.16 TLR4 TNF
7 positive regulation of chemokine production GO:0032722 8.96 TLR4 TNF
8 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.62 TLR4 TNF

Molecular functions related to Marburg Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 F2 TLR4

Sources for Marburg Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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