MBD
MCID: MRC001
MIFTS: 23

Marchiafava Bignami Disease (MBD)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Marchiafava Bignami Disease

MalaCards integrated aliases for Marchiafava Bignami Disease:

Name: Marchiafava Bignami Disease 52
Marchiafava-Bignami Disease 58 17 71
Mbd 52 58
Chronic Marchiafava-Bignami Syndrome 52
Acute Marchiafava-Bignami Disease 52

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 44 D054319
ICD10 via Orphanet 33 G37.1
UMLS via Orphanet 72 C0238265
Orphanet 58 ORPHA221074
UMLS 71 C0238265

Summaries for Marchiafava Bignami Disease

NIH Rare Diseases : 52 Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia . Seizures are common, and hemiparesis , aphasia , abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism.

MalaCards based summary : Marchiafava Bignami Disease, also known as marchiafava-bignami disease, is related to renal osteodystrophy and alcohol dependence. Affiliated tissues include brain, cortex and liver.

Wikipedia : 74 Marchiafava-Bignami disease is a progressive neurological disease of alcoholism, characterized by corpus... more...

Related Diseases for Marchiafava Bignami Disease

Diseases related to Marchiafava Bignami Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 renal osteodystrophy 11.7
2 alcohol dependence 11.1
3 chronic kidney disease 11.0
4 kidney disease 10.9
5 hyperparathyroidism 10.8
6 ocular motor apraxia 10.8
7 secondary hyperparathyroidism 10.8
8 alcohol use disorder 10.8
9 encephalopathy 10.8
10 apraxia 10.7
11 agraphia 10.7
12 dysgraphia 10.7
13 bone disease 10.7
14 ataxia and polyneuropathy, adult-onset 10.6
15 hyperphosphatemia 10.6
16 demyelinating disease 10.5
17 nominal aphasia 10.5
18 beriberi 10.5
19 wernicke encephalopathy 10.5
20 mutism 10.5
21 hypertonia 10.5
22 end stage renal disease 10.5
23 anorexia nervosa 10.4
24 dementia 10.4
25 ideomotor apraxia 10.4
26 brain edema 10.4
27 pellagra 10.4
28 subacute delirium 10.4
29 osteoporosis 10.4
30 bone mineral density quantitative trait locus 8 10.4
31 bone mineral density quantitative trait locus 15 10.4
32 rett syndrome 10.3
33 rickets 10.3
34 hand skill, relative 10.2
35 wernicke-korsakoff syndrome 10.2
36 kearns-sayre syndrome 10.2
37 human immunodeficiency virus type 1 10.2
38 aphasia 10.2
39 ptosis 10.2
40 middle east respiratory syndrome 10.2
41 dermatomyositis 10.2
42 respiratory failure 10.2
43 marasmus 10.2
44 quadriplegia 10.2
45 alexia 10.2
46 polyneuropathy 10.2
47 facial paralysis 10.2
48 postencephalitic parkinson disease 10.2
49 status epilepticus 10.2
50 optic nerve disease 10.2

Graphical network of the top 20 diseases related to Marchiafava Bignami Disease:



Diseases related to Marchiafava Bignami Disease

Symptoms & Phenotypes for Marchiafava Bignami Disease

Drugs & Therapeutics for Marchiafava Bignami Disease

Search Clinical Trials , NIH Clinical Center for Marchiafava Bignami Disease

Genetic Tests for Marchiafava Bignami Disease

Anatomical Context for Marchiafava Bignami Disease

MalaCards organs/tissues related to Marchiafava Bignami Disease:

40
Brain, Cortex, Liver, Pons

Publications for Marchiafava Bignami Disease

Articles related to Marchiafava Bignami Disease:

(show top 50) (show all 246)
# Title Authors PMID Year
1
Neurologic presentations of nutritional deficiencies. 52
19932379 2010
2
Simultaneous acute Marchiafava-Bignami disease and posterior reversible encephalopathy syndrome: a case almost misdiagnosed. 61
32550144 2020
3
Reversible lesion in the splenium of the corpus callosum in a patient with chronic alcoholism. 61
32489763 2020
4
Marchiafava-Bignami Disease: Two Chronologically Distinct Stages in the Same Patient. 61
32349853 2020
5
Comprehensive neuropsychological findings in a case of Marchiafava-Bignami disease. 61
32100611 2020
6
Marchiafava-Bignami disease: Report of three cases. 61
32057207 2020
7
Marchiafava Bignami Disease - A Case Report. 61
31979655 2020
8
Clinical and neuroradiological features of 15 patients diagnosed with Marchiafava-Bignami disease. 61
31283655 2019
9
Antemortem histopathology and imaging findings in a case of Marchiafava-Bignami disease. 61
31178304 2019
10
Marchiafava-Bignami disease with haemophagocytic lymphohistiocytosis as a postoperative complication of cardiac surgery. 61
31451466 2019
11
Intermittent alien hand syndrome caused by Marchiafava-Bignami disease: A case report. 61
31441866 2019
12
Refractory Nonconvulsive Status Epilepticus with Favorable Outcome in a Patient with Marchiafava-Bignami Disease. 61
30877698 2019
13
Marchiafava-Bignami Disease in a Patient with No Alcohol Abuse. 61
31512676 2019
14
Reversible "ears of the lynx" sign in Marchiafava-Bignami disease. 61
30014444 2019
15
Overreligious beliefs with neuropsychiatric manifestations in a young lady-Rule out Marchiafava-Bignami disease. 61
31065197 2019
16
Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease. 61
30338433 2019
17
Reversible MR Findings in Marchiafava-Bignami Disease. 61
30881711 2019
18
Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava-Bignami Disease: A Case Report and Literature Review. 61
30873016 2019
19
Marchiafava-Bignami disease. 61
29788472 2018
20
Marchiafava-Bignami Disease Presenting as Acute Psychosis. 61
30275629 2018
21
Left hemispatial neglect with a splenial lesion. 61
30370810 2018
22
Marchiafava-Bignami Disease with Cortical Involvement. 61
29945327 2018
23
A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters. 61
30283321 2018
24
Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency. 61
29169770 2018
25
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. 61
29482459 2018
26
Clinical and radiological features of Marchiafava-Bignami disease. 61
29384842 2018
27
Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis. 61
29465574 2018
28
Rapidly Resolving Nonalcoholic Marchiafava-Bignami Disease in the Setting of Malnourishment After Gastric Bypass Surgery. 61
30083556 2018
29
Marchiafava Bignami disease. 61
29133740 2017
30
Neuroimaging of chronic alcohol misuse. 61
27987266 2017
31
Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis. 61
28588358 2017
32
Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease. 61
28225048 2017
33
A rare case of Marchiafava-Bignami disease: Extracallosal lesions involving bilateral medipeduncle. 61
28488640 2017
34
Marchiafava-Bignami Disease: A Rare Clinical Dilemma. 61
28462561 2017
35
Vegetarian diet and excessive tea consumption: a dangerous association? 61
27525430 2017
36
Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease. 61
27646053 2016
37
Altered Sensorium in a Young Male: Marchiafava Bignami Disease Revisited. 61
27805345 2016
38
Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B). 61
27881585 2016
39
Marchiafava-Bignami disease in chronic alcoholic patient. 61
27594956 2016
40
Marchiafava-Bignami disease triggered by poorly controlled diabetes mellitus. 61
25728951 2016
41
[Marchiafava-Bignami disease (Case-report)]. 61
27390208 2016
42
Marchiafava-Bignami Disease with frontal cortex involvement and late onset, long-lasting psychiatric symptoms: a case report. 61
27183513 2016
43
Marchiafava: Bignami Disease Treated with Parenteral Thiamine. 61
27114628 2016
44
Marchiafava-Bignami disease in an AIDS patient. 61
26486496 2016
45
[A case of Marchiafava-Bignami disease suggesting vasogenic edema]. 61
26616486 2016
46
Marchiafava-Bignami and Alcohol Related Acute Polyneuropathy: The Cooccurrence of Two Rare Entities. 61
27668107 2016
47
Chronic stage of Marchiafava-Bignami disease. 61
26291992 2015
48
Neurologic Manifestations of Chronic Liver Disease and Liver Cirrhosis. 61
25908229 2015
49
Marchiafava-Bignami disease with asymmetric extracallosal lesions. 61
26322104 2015
50
Spinal anesthesia in a patient with Marchiafava-Bignami disease. 61
25634808 2015

Variations for Marchiafava Bignami Disease

Expression for Marchiafava Bignami Disease

Search GEO for disease gene expression data for Marchiafava Bignami Disease.

Pathways for Marchiafava Bignami Disease

GO Terms for Marchiafava Bignami Disease

Sources for Marchiafava Bignami Disease

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72 UMLS via Orphanet
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