MCID: MRK002
MIFTS: 28

Marek Disease

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Marek Disease

MalaCards integrated aliases for Marek Disease:

Name: Marek Disease 53 73
Neurolymphomatosis 53 59
Marek's Disease 53
Fowl Paralyses 53
Fowl Paralysis 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA206586
UMLS 73 C0024793

Summaries for Marek Disease

MalaCards based summary : Marek Disease, also known as neurolymphomatosis, is related to hemorrhage, intracerebral and lymphoma. An important gene associated with Marek Disease is H19 (H19, Imprinted Maternally Expressed Transcript
The mutant CVI/rpp38 was not only reactive with MAb H19 in IFA but also in immunoprecipitation.
Dysfunction Pattern: Mutation), and among its related pathways/superpathways are UVA-Induced MAPK Signaling and Mitophagy - animal. Affiliated tissues include t cells, and related phenotype is Decreased TP53 mRNA expression.

Wikipedia : 76 Marek\'s disease is a highly contagious viral neoplastic disease in chickens. It is named after József... more...

Related Diseases for Marek Disease

Graphical network of the top 20 diseases related to Marek Disease:



Diseases related to Marek Disease

Symptoms & Phenotypes for Marek Disease

GenomeRNAi Phenotypes related to Marek Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.62 JUN TP53

Drugs & Therapeutics for Marek Disease

Search Clinical Trials , NIH Clinical Center for Marek Disease

Genetic Tests for Marek Disease

Anatomical Context for Marek Disease

MalaCards organs/tissues related to Marek Disease:

41
T Cells

Publications for Marek Disease

Articles related to Marek Disease:

# Title Authors Year
1
The 132 bp repeats are present in RNA transcripts from 1.8 kb gene family of Marek disease virus-transformed cells. ( 8105666 )
1993
2
Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. ( 1315048 )
1992
3
The structure of Marek disease virus DNA: the presence of unique expansion in nonpathogenic viral DNA. ( 2983314 )
1985
4
Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. ( 6328512 )
1984
5
Inverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey. ( 6281774 )
1982

Variations for Marek Disease

Expression for Marek Disease

Search GEO for disease gene expression data for Marek Disease.

Pathways for Marek Disease

GO Terms for Marek Disease

Biological processes related to Marek Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.43 JUN TNFRSF8 TP53
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.32 HMGCR JUN
3 positive regulation of neuron apoptotic process GO:0043525 9.16 JUN TP53
4 protein tetramerization GO:0051262 8.96 HMGCR TP53
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 JUN TP53

Molecular functions related to Marek Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 8.62 HMGCR TP53

Sources for Marek Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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