MCID: MRK002
MIFTS: 34

Marek Disease

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Marek Disease

MalaCards integrated aliases for Marek Disease:

Name: Marek Disease 53 73
Neurolymphomatosis 53 59
Marek's Disease 53
Fowl Paralyses 53
Fowl Paralysis 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA206586
UMLS 73 C0024793

Summaries for Marek Disease

MalaCards based summary : Marek Disease, also known as neurolymphomatosis, is related to adult t-cell leukemia and lymphoma. An important gene associated with Marek Disease is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Mitophagy - animal and Copper homeostasis. Affiliated tissues include t cells, b cells and lung, and related phenotype is Decreased TP53 mRNA expression.

Wikipedia : 76 Marek''s disease is a highly contagious viral neoplastic disease in chickens. It is named after József... more...

Related Diseases for Marek Disease

Diseases related to Marek Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 29.2 TNFRSF8 TP53
2 lymphoma 10.6
3 b-cell lymphomas 10.4
4 diffuse large b-cell lymphoma 10.2
5 neuropathy 10.1
6 hemorrhage, intracerebral 10.1 ACE HMGCR
7 testicular torsion 10.0 ACE TP53
8 optic nerve neoplasm 10.0 ACE TP53
9 periosteal osteogenic sarcoma 10.0 JUN TP53
10 recessive dystrophic epidermolysis bullosa 10.0 JUN TP53
11 mycosis fungoides 10.0
12 testicular lymphoma 10.0
13 central nervous system lymphoma 10.0
14 primary central nervous system lymphoma 10.0
15 intravascular large b-cell lymphoma 10.0
16 follicular mucinosis 9.9 ACE TNFRSF8
17 coronary heart disease 1 9.9 ACE H19 HMGCR
18 vulvitis 9.9 GYPC TNFRSF8
19 laryngeal squamous cell carcinoma 9.8 H19 TP53
20 leukemia, chronic lymphocytic 2 9.8
21 burkitt lymphoma 9.8
22 leukemia, chronic lymphocytic 9.8
23 lymphoma, hodgkin, classic 9.8
24 sarcoma, synovial 9.8
25 lymphoma, non-hodgkin, familial 9.8
26 follicular lymphoma 9.8
27 leukemia 9.8
28 lymphoblastic lymphoma 9.8
29 marginal zone b-cell lymphoma 9.8
30 splenic marginal zone lymphoma 9.8
31 lymphocytic leukemia 9.8
32 sarcoma 9.8
33 cauda equina syndrome 9.8
34 patulous eustachian tube 9.8
35 guillain-barre syndrome 9.8
36 polyneuropathy 9.8
37 mononeuritis multiplex 9.8
38 sensory peripheral neuropathy 9.8
39 plexopathy 9.8
40 brachial plexus neuropathy 9.8
41 polyradiculoneuropathy 9.8
42 breast lymphoma 9.8
43 t-cell leukemia 9.8
44 sezary's disease 9.8
45 meningitis 9.8
46 hansen's disease 9.8
47 heparin-induced thrombocytopenia 9.8
48 leukemia, b-cell, chronic 9.8
49 neurosarcoidosis 9.8
50 dysphagia 9.8

Graphical network of the top 20 diseases related to Marek Disease:



Diseases related to Marek Disease

Symptoms & Phenotypes for Marek Disease

GenomeRNAi Phenotypes related to Marek Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.62 JUN TP53

Drugs & Therapeutics for Marek Disease

Search Clinical Trials , NIH Clinical Center for Marek Disease

Genetic Tests for Marek Disease

Anatomical Context for Marek Disease

MalaCards organs/tissues related to Marek Disease:

41
T Cells, B Cells, Lung, Heart, Testes

Publications for Marek Disease

Articles related to Marek Disease:

(show top 50) (show all 128)
# Title Authors Year
1
Cauda equina syndrome secondary to neurolymphomatosis: Case report and literature review. ( 28941783 )
2018
2
Diffuse Large B-Cell Lymphoma Recurring as Neurolymphomatosis on FDG PET/CT. ( 30516683 )
2018
3
Two-year-old female with EBV-positive diffuse large B-cell lymphoma and subsequent CNS involvement with neurolymphomatosis. ( 30151967 )
2018
4
First pathological report of a de novo CD5-positive diffuse large B-cell lymphoma patient presenting with Guillain-Barré syndrome-like neuropathy due to neurolymphomatosis. ( 29718563 )
2018
5
Acute demyelinating neuropathy in a patient with neurolymphomatosis. ( 29507018 )
2018
6
Neurolymphomatosis in non-Hodgkin lymphoma with cranial multineuritis: A case report. ( 29642156 )
2018
7
FDG PET-CT evaluation in neurolymphomatosis: imaging characteristics and clinical outcomes. ( 28750592 )
2018
8
Neurolymphomatosis of the Brachial Plexus and its Branches: Case Series and Literature Review. ( 29307326 )
2018
9
Patient With 2 Hematologic Malignancies Presenting as Neurolymphomatosis. ( 29465612 )
2018
10
Partial Conduction Block as an Early Nerve Conduction Finding in Neurolymphomatosis. ( 29629543 )
2018
11
Ocular involvement in neurolymphomatosis. ( 29780925 )
2018
12
Pathology of Nerve Biopsy and Diagnostic Yield of PCR-Based Clonality Testing in Neurolymphomatosis. ( 30011033 )
2018
13
Homonymous Hemianopia: A Rare Presentation of Secondary Central Nervous System Neurolymphomatosis. ( 30062082 )
2018
14
Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy. ( 30101916 )
2018
15
Burkitt's neurolymphomatosis of the trigeminal nerve. ( 30115722 )
2018
16
Neurolymphomatosis Appeared Following Primary Central Nervous System Lymphoma. ( 28202873 )
2017
17
FDG PET to Diagnose Neurolymphomatosis in a Case of Triple-Hit B-Cell Lymphoma. ( 28240665 )
2017
18
Neurolymphomatosis as a relapse of primary cerebral nervous system lymphoma. ( 27686620 )
2017
19
Primary neurolymphomatosis as clinical onset of chronic lymphocytic leukemia. ( 27761605 )
2017
20
Evolution of Neurolymphomatosis to Lymphomatosis Cerebri. ( 28176503 )
2017
21
Neurolymphomatosis Caused by Nasal-type Extranodal Natural Killer/T-cell Lymphoma. ( 28230000 )
2017
22
18F-FDG PET/CT/MRI Fusion Images Showing Cranial and Peripheral Nerve Involvement in Neurolymphomatosis. ( 28242998 )
2017
23
FDG PET/CT in Pediatric Neurolymphomatosis. ( 28288046 )
2017
24
Bilateral sciatic nerve neurolymphomatosis: PET/CT findings. ( 28374164 )
2017
25
Diagnosis of secondary peripheral neurolymphomatosis: a multi-center experience. ( 28482727 )
2017
26
Two Cases of Neurolymphomatosis with Fatal Bilateral Vocal Cord Paralysis that were Diagnosed with 18F-fluorodeoxyglucose Positron Emission Tomography (FDG PET)/CT. ( 28502935 )
2017
27
Neurolymphomatosis of the thoracic sympathetic chain. ( 28939669 )
2017
28
Neurolymphomatosis: A Surreal Presentation of Lymphoma. ( 29200675 )
2017
29
A case of neurolymphomatosis caused by follicular lymphoma successfully treated with bendamustine. ( 26783429 )
2016
30
Neurolymphomatosis: MRI and (18) FDG-PET features. ( 25974748 )
2016
31
Diagnostic and response assessment FDG PET-CT in neurolymphomatosis. ( 27980756 )
2016
32
Disseminated extranodal marginal zone lymphoma involving the gastrocnemius muscle with sural neurolymphomatosis. ( 26198215 )
2015
33
Neurological picture. Neurolymphomatosis as the primary presentation of non-Hodgkin's Lymphoma. ( 25053772 )
2015
34
Fluorothymidine PET/CT in neurolymphomatosis. ( 25546221 )
2015
35
Neurolymphomatosis: A report of 2 cases representing opposite ends of the clinical spectrum. ( 25758704 )
2015
36
Primary Central Nervous System Lymphoma of the Cerebellopontine Angle That Initially Occurred as Neurolymphomatosis of the Acoustic Nerve. ( 28663949 )
2014
37
Neurolymphomatosis in a patient with extranodal NK/T-cell lymphoma, nasal-type: a case report and literature review. ( 24583438 )
2014
38
Primary neurolymphomatosis diagnosis and treatment: a retrospective study. ( 24831985 )
2014
39
Neurolymphomatosis in three horses with multicentric T-cell-rich B-cell lymphoma. ( 24915887 )
2014
40
Neurolymphomatosis: a case series of clinical manifestations, treatments, and outcomes. ( 24928074 )
2014
41
(18)F-fluoro-2-deoxy-D-glucose positron emission tomography findings of neurolymphomatosis. ( 25025007 )
2014
42
Neurolymphomatosis exhibiting repeated exacerbation and remission in both the peripheral and central nervous systems. ( 25082781 )
2014
43
Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report. ( 25083392 )
2014
44
Usefulness of 18F-FDG PET/CT in the detection of neurolymphomatosis. ( 25144562 )
2014
45
Positron emission tomography/computerized tomography imaging of multiple focus of neurolymphomatosis. ( 25400366 )
2014
46
(18)F-FDG PET/CT in Neurolymphomatosis: Report of 3 Cases. ( 27408859 )
2014
47
Neurolymphomatosis diagnosed by (18)F-FDG PET-CT. ( 22996248 )
2013
48
Solitary neurolymphomatosis of the brachial plexus mimicking benign nerve sheath tumour: case report. ( 23131120 )
2013
49
Teaching NeuroImages: diagnostic utility of FDG-PET in neurolymphomatosis. ( 23817522 )
2013
50
Bilateral secondary neurolymphomatosis of the internal auditory canal nerves: a case report. ( 23993712 )
2013

Variations for Marek Disease

Expression for Marek Disease

Search GEO for disease gene expression data for Marek Disease.

Pathways for Marek Disease

GO Terms for Marek Disease

Biological processes related to Marek Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.33 JUN TNFRSF8 TP53
2 Ras protein signal transduction GO:0007265 9.32 JUN TP53
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.26 HMGCR JUN
4 protein tetramerization GO:0051262 8.96 HMGCR TP53
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 JUN TP53

Molecular functions related to Marek Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 8.62 HMGCR TP53

Sources for Marek Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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