MCID: MRG002
MIFTS: 23

Marginal Corneal Ulcer

Categories: Eye diseases

Aliases & Classifications for Marginal Corneal Ulcer

MalaCards integrated aliases for Marginal Corneal Ulcer:

Name: Marginal Corneal Ulcer 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10441
ICD9CM 34 370.01
SNOMED-CT 67 47398006
ICD10 32 H16.04
UMLS 71 C0155067

Summaries for Marginal Corneal Ulcer

Disease Ontology : 12 A corneal ulcer that is characterized by infiltrate formation in the marginal zone that is parallel but separated from the limbus.

MalaCards based summary : Marginal Corneal Ulcer is related to erythrasma and gastrointestinal ulceration, recurrent, with dysfunctional platelets. An important gene associated with Marginal Corneal Ulcer is DEFB4B (Defensin Beta 4B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include eye.

Related Diseases for Marginal Corneal Ulcer

Diseases related to Marginal Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 erythrasma 10.2 DEFB4B DEFB4A
2 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
3 conjunctivitis 10.1
4 corneal ulcer 10.1
5 blepharitis 10.1
6 dacryoadenitis 10.1
7 dacryocystitis 10.1
8 multidrug-resistant tuberculosis 10.1 IL1A CAT
9 cryptosporidiosis 10.1 IL1A CAT
10 tinea cruris 10.1 FLNA DEFB4A
11 familial progressive hyperpigmentation 10.0 HGF FGF7
12 gingival disease 10.0 IL1A DEFB4A
13 dermatophytosis 10.0 FLNA DEFB4A
14 aseptic meningitis 10.0 IL1A CAT
15 oral candidiasis 10.0 IL1A DEFB4A
16 scabies 10.0 IL1A FLNA
17 lacrimal duct defect 9.9
18 temporal arteritis 9.9
19 mooren's ulcer 9.9
20 allergic hypersensitivity disease 9.9
21 scleritis 9.9
22 posterior scleritis 9.9
23 iritis 9.9
24 cataract 9.9
25 vasculitis 9.9
26 chronic dacryocystitis 9.9
27 chronic graft versus host disease 9.9 TNFSF13B IL1A
28 aphthous stomatitis 9.9 IL1A CAT
29 indolent myeloma 9.9 IL1RAP CASP1
30 cholesteatoma of middle ear 9.8 IL1A FGF7 DEFB4A
31 aggressive periodontitis 9.8 IL1A DEFB4A
32 asbestosis 9.8 CAT CASP1
33 paratyphoid fever 9.7 IL1A CASP1
34 familial cold autoinflammatory syndrome 9.7 IL1RAP CASP1
35 short bowel syndrome 9.7 HGF FLNA FGF7
36 silicosis 9.5 IL1A CAT CASP1
37 pulmonary fibrosis, idiopathic 9.5 IL1A HGF FGF7
38 bacterial infectious disease 9.5 IL1A DEFB4A CASP1
39 cinca syndrome 9.4 IL1RAP CASP1
40 chronic granulomatous disease 9.4 TNFSF13B CAT CASP1
41 bone disease 9.0 IL1A HGF FLNA CASP1
42 skin disease 8.9 IL1A FGF7 DEFB4A CAT CASP1
43 inflammatory bowel disease 8.5 IL1A HGF FGF7 DEFB4A CAT CASP1

Graphical network of the top 20 diseases related to Marginal Corneal Ulcer:



Diseases related to Marginal Corneal Ulcer

Symptoms & Phenotypes for Marginal Corneal Ulcer

Drugs & Therapeutics for Marginal Corneal Ulcer

Search Clinical Trials , NIH Clinical Center for Marginal Corneal Ulcer

Genetic Tests for Marginal Corneal Ulcer

Anatomical Context for Marginal Corneal Ulcer

MalaCards organs/tissues related to Marginal Corneal Ulcer:

40
Eye

Publications for Marginal Corneal Ulcer

Articles related to Marginal Corneal Ulcer:

# Title Authors PMID Year
1
Keratitis with Kocuria palustris and Rothia mucilaginosa in Vitamin A Deficiency. 61
24707276 2014
2
Treatment of Mooren's and Mooren's-like ulcer by lamellar keratectomy: report of six eyes and literature review. 61
3309765 1987
3
[Keratomalacia perforans, clinical and pathohistologic findings]. 61
3906252 1985
4
Marginal corneal ulcer due to beta-streptococcus. 61
843277 1977

Variations for Marginal Corneal Ulcer

Expression for Marginal Corneal Ulcer

Search GEO for disease gene expression data for Marginal Corneal Ulcer.

Pathways for Marginal Corneal Ulcer

Pathways related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 TNFSF13B IL1RAP IL1A HGF FGF7 DEFB4B
2
Show member pathways
12.84 TNFSF13B IL1RAP IL1A HGF FGF7 CASP1
3
Show member pathways
12.7 TNFSF13B IL1A HGF FLNA FGF7 CASP1
4
Show member pathways
12.33 TNFSF13B IL1A HGF FGF7
5
Show member pathways
11.96 IL1RAP IL1A CASP1
6 11.87 DEFB4B DEFB4A CASP1
7 11.77 IL1RAP IL1A HGF FLNA FGF7 CASP1
8 11.45 IL1A FLNA CASP1
9 11.23 IL1RAP IL1A
10 10.66 TNFSF13B IL1A HGF FGF7
11 10.17 IL1A CASP1

GO Terms for Marginal Corneal Ulcer

Cellular components related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 TNFSF13B IL1A HGF DEFB4B DEFB4A CAT
2 extracellular region GO:0005576 9.28 TNFSF13B IL1RAP IL1A HGF FLNA FGF7

Biological processes related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.62 IL1RAP IL1A HGF CASP1
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.58 IL1A FLNA CASP1
3 cell chemotaxis GO:0060326 9.54 HGF DEFB4B DEFB4A
4 killing of cells of other organism GO:0031640 9.46 DEFB4B DEFB4A
5 protein localization to cell surface GO:0034394 9.43 FLNA FGF7
6 immune response GO:0006955 9.35 TNFSF13B IL1RAP IL1A DEFB4B DEFB4A
7 positive regulation of cell division GO:0051781 9.33 IL1A FGF7 CAT
8 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.26 HGF FGF7
9 positive chemotaxis GO:0050918 8.92 HGF FGF7 DEFB4B DEFB4A

Molecular functions related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1RAP IL1A
2 CCR6 chemokine receptor binding GO:0031731 8.96 DEFB4B DEFB4A
3 chemoattractant activity GO:0042056 8.92 HGF FGF7 DEFB4B DEFB4A

Sources for Marginal Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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