MCID: MRG002
MIFTS: 24

Marginal Corneal Ulcer

Categories: Neuronal diseases

Aliases & Classifications for Marginal Corneal Ulcer

MalaCards integrated aliases for Marginal Corneal Ulcer:

Name: Marginal Corneal Ulcer 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10441
ICD9CM 34 370.01
SNOMED-CT 67 47398006
ICD10 32 H16.04
UMLS 71 C0155067

Summaries for Marginal Corneal Ulcer

Disease Ontology : 12 A corneal ulcer that is characterized by infiltrate formation in the marginal zone that is parallel but separated from the limbus.

MalaCards based summary : Marginal Corneal Ulcer is related to acute pericementitis and verruciform xanthoma of skin. An important gene associated with Marginal Corneal Ulcer is DEFB4B (Defensin Beta 4B), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. Affiliated tissues include eye.

Related Diseases for Marginal Corneal Ulcer

Diseases related to Marginal Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 138, show less)
# Related Disease Score Top Affiliating Genes
1 acute pericementitis 10.5 DEFB4B DEFB4A
2 verruciform xanthoma of skin 10.4 CD1E CD1A
3 chronic laryngitis 10.4 CD1E CD1A
4 tinea pedis 10.4 DEFB4B DEFB4A
5 multifocal motor neuropathy 10.4 CD1E CD1A
6 necrobiosis lipoidica 10.4 CD1E CD1A
7 skin sarcoidosis 10.4 CD1E CD1B
8 tinea cruris 10.3 FLNA DEFB4A
9 familial progressive hyperpigmentation 10.3 HGF FGF7
10 tinea corporis 10.3 FLNA DEFB4A
11 pityriasis rosea 10.3 CD1E CD1A
12 granulomatous dermatitis 10.2 CD1C CD1B
13 urogenital tuberculosis 10.2 CRP CAT
14 epithelial malignant thymoma 10.2 CD1E CD1B CD1A
15 dendritic cell thymoma 10.2 CD1E CD1B CD1A
16 anaerobic meningitis 10.2 FLNA CRP
17 bacteremia 2 10.2 CRP CAT
18 skeletal tuberculosis 10.2 FLNA CRP
19 tinea unguium 10.1 FLNA CRP
20 capillary lymphangioma 10.1 FLNA CRP
21 myeloperoxidase deficiency 10.1 MPO CAT
22 interval angle-closure glaucoma 10.1 FLNA CRP
23 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
24 conjunctivitis 10.1
25 corneal ulcer 10.1
26 blepharitis 10.1
27 dacryoadenitis 10.1
28 dacryocystitis 10.1
29 renal infectious disease 10.1 CRP CASP1
30 late congenital syphilis 10.1 FLNA CRP
31 short bowel syndrome 10.1 HGF FLNA FGF7
32 indolent myeloma 10.0 IL1RAP IL1A
33 folliculitis 10.0 DEFB4A CD1E CD1B CD1A
34 acanthoma 10.0 FGF7 CD1E CD1B CD1A
35 subungual glomus tumor 10.0 FLNA CRP
36 orbital granuloma 10.0 MPO CRP
37 encapsulated thymoma 10.0 CD1E CD1C CD1B CD1A
38 central nervous system sarcoma 10.0 CD1E CD1C CD1B CD1A
39 adult respiratory distress syndrome 10.0 MPO FGF7 CAT
40 lichen nitidus 10.0 CD1E CD1C CD1B CD1A
41 interdigitating dendritic cell sarcoma 10.0 CD1E CD1C CD1B CD1A
42 orbital cancer 10.0 CD1E CD1C CD1B CD1A
43 juvenile xanthogranuloma 10.0 CD1E CD1C CD1B CD1A
44 erdheim-chester disease 10.0 CD1E CD1C CD1B CD1A
45 fibrosarcoma of bone 10.0 CD1E CD1C CD1B CD1A
46 diabetes insipidus, neurohypophyseal 10.0 CD1E CD1C CD1B CD1A
47 keratosis, seborrheic 10.0 CD1E CD1C CD1B CD1A
48 connective tissue benign neoplasm 10.0 CD1E CD1C CD1B CD1A
49 thymus cancer 10.0 CD1E CD1C CD1B CD1A
50 multiple cranial nerve palsy 9.9 MPO CRP
51 lacrimal duct defect 9.9
52 temporal arteritis 9.9
53 mooren's ulcer 9.9
54 allergic hypersensitivity disease 9.9
55 scleritis 9.9
56 posterior scleritis 9.9
57 iritis 9.9
58 cataract 9.9
59 vasculitis 9.9
60 chronic dacryocystitis 9.9
61 dendritic cell tumor 9.9 MPO CD1A
62 chronic graft versus host disease 9.9 TNFSF13B IL1A
63 primary bacterial infectious disease 9.9 CRP CAT CASP1
64 asbestosis 9.9 MPO CAT CASP1
65 mediastinitis 9.9 MPO CRP
66 mononeuritis of upper limb and mononeuritis multiplex 9.9 MPO CRP
67 mononeuritis multiplex 9.9 MPO CRP
68 cryptosporidiosis 9.9 IL1A DEFB4A CAT
69 subacute bacterial endocarditis 9.9 MPO CRP
70 adhesive otitis media 9.9 MPO FLNA
71 aortitis 9.8 MPO CRP
72 mastoiditis 9.8 MPO CRP
73 cholesteatoma of middle ear 9.8 IL1A FGF7 DEFB4A
74 xerophthalmia 9.8 TNFSF13B CRP
75 brucellosis 9.8 MPO CRP CAT
76 psoriasis 15 9.8 DEFB4A CD1E CD1C CD1B CD1A
77 chondromalacia 9.8 MPO CRP
78 maxillary sinusitis 9.8 MPO CRP
79 silicosis 9.7 IL1A CAT CASP1
80 scleral disease 9.7 MPO CRP
81 bronchitis 9.7 MPO CRP CAT
82 mycosis fungoides 9.7 CD1C CD1B CD1A
83 autoimmune disease of blood 9.7 TNFSF13B MPO CRP
84 aseptic meningitis 9.7 IL1A CRP CAT
85 meningitis 9.7 IL1A CRP CAT
86 gingival disease 9.7 IL1A DEFB4A CRP
87 vaginal disease 9.6 IL1A DEFB4A CRP
88 sebaceous gland disease 9.6 IL1A DEFB4A CRP
89 endocarditis 9.6 IL1A CRP CAT
90 granulomatosis with polyangiitis 9.6 TNFSF13B MPO CRP
91 chronic granulomatous disease 9.6 TNFSF13B MPO CAT CASP1
92 malignant histiocytic disease 9.6 CD1E CD1D CD1C CD1B CD1A
93 mycobacterium malmoense 9.6 CD1E CD1D CD1C CD1B CD1A
94 rhinoscleroma 9.6 CD1E CD1D CD1C CD1B CD1A
95 reticulohistiocytic granuloma 9.6 CD1E CD1D CD1C CD1B CD1A
96 langerhans cell sarcoma 9.6 CD1E CD1D CD1C CD1B CD1A
97 spongiotic dermatitis 9.6 CD1E CD1D CD1C CD1B CD1A
98 balloon cell malignant melanoma 9.6 CD1E CD1D CD1C CD1B CD1A
99 inflamed seborrheic keratosis 9.6 CD1E CD1D CD1C CD1B CD1A
100 histiocytic and dendritic cell cancer 9.6 CD1E CD1D CD1C CD1B CD1A
101 granuloma annulare 9.6 CD1E CD1D CD1C CD1B CD1A
102 non-langerhans-cell histiocytosis 9.6 CD1E CD1D CD1C CD1B CD1A
103 central epithelioid sarcoma 9.6 CD1E CD1D CD1C CD1B CD1A
104 vulvar proximal-type epithelioid sarcoma 9.6 CD1E CD1D CD1C CD1B CD1A
105 adult xanthogranuloma 9.6 CD1E CD1D CD1C CD1B CD1A
106 mycobacterium tuberculosis 1 9.6 DEFB4A CRP CD1C CD1B CD1A
107 lichen disease 9.6 CD1E CD1D CD1C CD1B CD1A
108 histiocytosis-lymphadenopathy plus syndrome 9.6 CD1E CD1D CD1C CD1B CD1A
109 thymus gland disease 9.6 CD1E CD1D CD1C CD1B CD1A
110 tonsillitis 9.6 MPO IL1A DEFB4A
111 gingivitis 9.6 MPO IL1A DEFB4A
112 paratyphoid fever 9.5 IL1A CRP CASP1
113 typhoid fever 9.5 IL1A CRP CASP1
114 acute pancreatitis 9.5 MPO CRP CASP1
115 familial mediterranean fever 9.5 IL1A CRP CASP1
116 chlamydia 9.5 IL1A CRP CASP1
117 bone inflammation disease 9.4 IL1A CRP CASP1
118 autoimmune vasculitis 9.4 MPO CRP
119 muckle-wells syndrome 9.4 IL1RAP IL1A CRP CASP1
120 leprosy 3 9.3 FLNA CD1E CD1D CD1C CD1B CD1A
121 proteasome-associated autoinflammatory syndrome 1 9.3 MPO IL1A CRP
122 bacterial infectious disease 9.3 IL1A DEFB4A CRP CASP1
123 polyclonal hypergammaglobulinemia 9.3 TNFSF13B CRP CD1E CD1C CD1B CD1A
124 bone disease 9.3 IL1A HGF FLNA CASP1
125 pulmonary fibrosis, idiopathic 9.2 IL1A HGF FGF7 CRP
126 pneumonia 9.2 MPO IL1A DEFB4A CRP
127 periodontitis 9.2 MPO IL1A DEFB4A CRP
128 lymphoid interstitial pneumonia 9.2 CRP CD1E CD1D CD1C CD1B CD1A
129 seborrheic dermatitis 9.2 IL1A DEFB4A CD1E CD1C CD1B CD1A
130 leber plus disease 9.1 MPO CD1E CD1D CD1C CD1B CD1A
131 otitis media 9.0 MPO IL1A CRP
132 exophthalmos 9.0 FLNA CRP CD1E CD1D CD1C CD1B
133 lung disease 8.9 MPO IL1A FLNA FGF7 CRP
134 behcet syndrome 8.8 TNFSF13B MPO IL1A CRP CASP1
135 malaria 8.5 TNFSF13B MPO IL1A CRP CAT CASP1
136 skin disease 8.5 IL1A FGF7 DEFB4A CRP CD1C CD1A
137 myocardial infarction 8.5 MPO IL1A HGF CRP CAT CASP1
138 inflammatory bowel disease 8.2 MPO IL1A HGF FGF7 DEFB4A CRP

Graphical network of the top 20 diseases related to Marginal Corneal Ulcer:



Diseases related to Marginal Corneal Ulcer

Symptoms & Phenotypes for Marginal Corneal Ulcer

Drugs & Therapeutics for Marginal Corneal Ulcer

Search Clinical Trials , NIH Clinical Center for Marginal Corneal Ulcer

Genetic Tests for Marginal Corneal Ulcer

Anatomical Context for Marginal Corneal Ulcer

MalaCards organs/tissues related to Marginal Corneal Ulcer:

40
Eye

Publications for Marginal Corneal Ulcer

Articles related to Marginal Corneal Ulcer:

(showing 4, show less)
# Title Authors PMID Year
1
Keratitis with Kocuria palustris and Rothia mucilaginosa in Vitamin A Deficiency. 61
24707276 2014
2
Treatment of Mooren's and Mooren's-like ulcer by lamellar keratectomy: report of six eyes and literature review. 61
3309765 1987
3
[Keratomalacia perforans, clinical and pathohistologic findings]. 61
3906252 1985
4
Marginal corneal ulcer due to beta-streptococcus. 61
843277 1977

Variations for Marginal Corneal Ulcer

Expression for Marginal Corneal Ulcer

Search GEO for disease gene expression data for Marginal Corneal Ulcer.

Pathways for Marginal Corneal Ulcer

Pathways related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

(showing 9, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 TNFSF13B MPO IL1RAP IL1A HGF FGF7
2
Show member pathways
13 TNFSF13B IL1A HGF FLNA FGF7 CASP1
3 12.47 IL1RAP IL1A HGF FLNA FGF7 CASP1
4 11.86 CD1E CD1D CD1C CD1B CD1A
5 11.8 CD1D CD1C CD1B CD1A
6 11.56 CD1E CD1D CD1C CD1B CD1A
7 11.48 CD1D CD1C CD1A
8 11.1 IL1A CD1E CD1D CD1C CD1B CD1A
9 10.25 IL1A CASP1

GO Terms for Marginal Corneal Ulcer

Cellular components related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.77 CD1E CD1D CD1C CD1B CD1A
2 extracellular region GO:0005576 9.7 TNFSF13B MPO IL1RAP IL1A HGF FLNA
3 external side of plasma membrane GO:0009897 9.65 CD1E CD1D CD1C CD1B CD1A
4 lysosome GO:0005764 9.63 MPO CD1E CD1D CD1C CD1B CAT
5 endosome membrane GO:0010008 9.62 CD1D CD1C CD1B CD1A
6 extracellular space GO:0005615 9.44 TNFSF13B MPO IL1A HGF DEFB4B DEFB4A

Biological processes related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

(showing 12, show less)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 TNFSF13B IL1RAP CD1E CD1D CD1C CD1B
2 immune response GO:0006955 9.85 TNFSF13B IL1RAP IL1A DEFB4B DEFB4A CD1E
3 cytokine-mediated signaling pathway GO:0019221 9.8 IL1RAP IL1A HGF CASP1
4 regulation of immune response GO:0050776 9.77 TNFSF13B CD1D CD1C CD1B CD1A
5 defense response to Gram-positive bacterium GO:0050830 9.69 DEFB4B DEFB4A CRP
6 cell chemotaxis GO:0060326 9.65 HGF DEFB4B DEFB4A
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.65 CD1E CD1D CD1C CD1B CD1A
8 positive regulation of cell division GO:0051781 9.63 IL1A FGF7 CAT
9 positive chemotaxis GO:0050918 9.62 HGF FGF7 DEFB4B DEFB4A
10 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.43 HGF FGF7
11 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
12 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Marginal Corneal Ulcer according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.56 HGF FGF7 DEFB4B DEFB4A
2 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
3 interleukin-1 receptor binding GO:0005149 9.37 IL1RAP IL1A
4 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
5 CCR6 chemokine receptor binding GO:0031731 9.32 DEFB4B DEFB4A
6 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Marginal Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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