Mast Cell Activation Syndrome (MCAS)

Categories: Rare diseases

Aliases & Classifications for Mast Cell Activation Syndrome

MalaCards integrated aliases for Mast Cell Activation Syndrome:

Name: Mast Cell Activation Syndrome 52
Mcas 52 17


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Summaries for Mast Cell Activation Syndrome

NIH Rare Diseases : 52 Mast cell activation syndrome (MCAS), is an immunological condition in which mast cells mistakenly release too many chemical mediators, resulting in several chronic symptoms involving the skin, gastrointestinal tract, heart, respiratory, and neurologic systems. Mast cells are present throughout most of our bodies and secrete different chemicals during allergic reactions. Symptoms include episodes of abdominal pain, cramping, diarrhea, flushing, itching, wheezing, coughing, lightheadedness and potential problems with "brain fog" or other difficulties with memory. The cause of MCAS is unknown. Treatment includes several combinations of medications like anti-histamines and mast cell stabilizers .

MalaCards based summary : Mast Cell Activation Syndrome, also known as mcas, is related to monoclonal mast cell activation syndrome and nguyen syndrome. An important gene associated with Mast Cell Activation Syndrome is CHIT1 (Chitinase 1). The drugs Fibrinolytic Agents and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skin.

Wikipedia : 74 Mast cell activation syndrome (MCAS) is one type of mast cell activation disorder (MCAD), and is an... more...

Related Diseases for Mast Cell Activation Syndrome

Diseases related to Mast Cell Activation Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 monoclonal mast cell activation syndrome 12.8
2 nguyen syndrome 11.6
3 multiple congenital anomalies/dysmorphic syndrome-intellectual disability 11.6
4 richieri-costa/guion-almeida syndrome 11.3
5 gapo syndrome 11.2
6 opitz-kaveggia syndrome 11.2
7 benjamin syndrome 11.2
8 kagami-ogata syndrome 11.2
9 genetic multiple congenital anomalies/dysmorphic syndrome without intellectual disability 11.2
10 genetic multiple congenital anomalies/dysmorphic syndrome-variable intellectual disability syndrome 11.2
11 multiple congenital anomalies/dysmorphic syndrome-variable intellectual disability syndrome 11.2
12 multiple congenital anomalies/dysmorphic syndrome without intellectual disability 11.2
13 aneurysm 10.6
14 mastocytosis 10.5
15 moyamoya disease 1 10.5
16 cerebrovascular disease 10.4
17 systemic mastocytosis 10.4
18 microcephaly 10.4
19 cerebral artery occlusion 10.3
20 breast cancer 10.3
21 cerebral aneurysms 10.3
22 breast disease 10.3
23 carotid artery occlusion 10.3
24 stroke, ischemic 10.2
25 hypotonia 10.2
26 cleft palate, isolated 10.2
27 transient cerebral ischemia 10.2
28 hemiplegia 10.2
29 brain edema 10.2
30 hydrops, lactic acidosis, and sideroblastic anemia 10.1
31 cleft lip 10.1
32 chromosomal triplication 10.1
33 allergic hypersensitivity disease 10.1
34 urticaria 10.1
35 angioedema 10.1
36 scoliosis 10.1
37 ptosis 10.1
38 dysostosis 10.1
39 fibrosarcoma 10.1
40 cataract 10.1
41 epicanthus 10.0
42 hypertelorism 10.0
43 ovarian cancer 10.0
44 chromosome 2q35 duplication syndrome 10.0
45 telecanthus 10.0
46 ocular motor apraxia 10.0
47 thrombosis 10.0
48 microphthalmia 10.0
49 hypospadias 10.0
50 sarcoma 10.0

Graphical network of the top 20 diseases related to Mast Cell Activation Syndrome:

Diseases related to Mast Cell Activation Syndrome

Symptoms & Phenotypes for Mast Cell Activation Syndrome

Drugs & Therapeutics for Mast Cell Activation Syndrome

Drugs for Mast Cell Activation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrinolytic Agents Phase 3
2 Immunologic Factors

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE) Trial Terminated NCT01778335 Phase 3
2 Ketamine and Hydromorphone PCA Analgesia for Antineoplastic-Induced Pediatric Mucositis Withdrawn NCT00474110 Phase 3 Ketamine & hydromorphone
3 An Open-Label Phase 1 Study to Investigate the Safety and Efficacy of CYP-001 for the Treatment of Adults With Steroid-Resistant Acute Graft Versus Host Disease Active, not recruiting NCT02923375 Phase 1
4 The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients Unknown status NCT00886054
5 The Significance of Blood-tryptase Levels and c-Kit Mutation in the Evaluation of Prognosis and Adverse Reactions in Subjects Undergoing Venom Immunotherapy for Insect Allergy Completed NCT02503800
6 Tissue Oxygen Index and Pulsatility Index in Orthopedic Surgery: a NIRS and TCD Pilot Trial Completed NCT02340416
7 Cerebral Blood Flow Parameters and Neurobehavioral Development in Full-Term Infants and Very Low Birth Weight Preterm Infants at Term Age Completed NCT00676247
8 Influence of Cerebral Blood Supply During Cardiopulmonary Bypass on the Incidence of Postoperative Delirium in Open-heart Surgery Completed NCT03117712
9 A Case-control Study of Independent Predictors of Middle Cerebral Artery Aneurysm. Completed NCT03493035
10 Assessment of Mast Cell Activation Diagnostic Test in Patients With Allergic Disease Recruiting NCT03406325
11 A Novel Non-invasive Technique of Cerebral Compliance and Auto-regulation Assessment Recruiting NCT03144219
12 Utilizing the RESCUE Stroke Caregiver Website to Enhance Discharge Planning Recruiting NCT01600131
13 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Active, not recruiting NCT02761473
14 Feasibility Study: Does a Designated Education Session Change Levels of Catastrophizing, Kinesiophobia and Pain Beliefs in Patients With Patellofemoral Pain? Active, not recruiting NCT03784339

Search NIH Clinical Center for Mast Cell Activation Syndrome

Genetic Tests for Mast Cell Activation Syndrome

Anatomical Context for Mast Cell Activation Syndrome

MalaCards organs/tissues related to Mast Cell Activation Syndrome:

Brain, Heart, Skin, Testes, Bone, Breast, Endothelial

Publications for Mast Cell Activation Syndrome

Articles related to Mast Cell Activation Syndrome:

(show top 50) (show all 960)
# Title Authors PMID Year
Mast Cells, Mastocytosis, and Related Disorders. 52
26154789 2015
Mast Cell Activation Syndrome: Tools for Diagnosis and Differential Diagnosis. 61
31470118 2020
Comparing histamine intolerance and non-clonal mast cell activation syndrome. 61
32013319 2020
Timing of response and long term efficacy of Omalizumab in non-clonal Mast Cell Activation Syndrome: A case series. 61
31735545 2020
Fatal anaphylaxis following a hornet sting in a yellow jacket venom-sensitized patient with undetected monoclonal mast cell activation syndrome and without previous history of a systemic sting reaction. 61
31279041 2020
Mast Cell Activation: When the Whole Is Greater than the Sum of Its Parts. 61
31757235 2020
Venom immunotherapy in patients with clonal mast cell disorders: IgG4 correlates with protection. 61
31306487 2020
Survey of Mast Cell Mediator Levels from Patients Presenting with Symptoms of Mast Cell Activation. 61
31722348 2020
Restless legs syndrome is associated with mast cell activation syndrome. 61
31994488 2020
Detection of spreading depolarizations in a middle cerebral artery occlusion model in swine. 61
31940093 2020
Optical coherence tomography angiography for marginal corneal vascular remodelling after pterygium surgery with limbal-conjunctival autograft. 61
31992861 2020
Prenatal metyrapone treatment modulates neonatal cerebrovascular structure, function, and vulnerability to mild hypoxic-ischemic injury. 61
31577477 2020
Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition. 61
31645370 2020
A New Transcranial Doppler Scoring System for Evaluating Middle Cerebral Artery Stenosis. 61
31721367 2020
Dysfunction of the endothelium and constriction of the isolated rat's middle cerebral artery in low sodium environment in the presence of vasopressin. 61
31876005 2019
Hypertension Exacerbates Cerebrovascular Oxidative Stress Induced by Mild Traumatic Brain Injury: Protective Effects of the Mitochondria-Targeted Antioxidative Peptide SS-31. 61
31266393 2019
Expression, purification and characterisation of Trypanosoma congolense metacaspase 5 (TcoMCA5) - a potential drug target for animal African trypanosomiasis. 61
31377239 2019
Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index. 61
31889363 2019
Tumor cell‑fibroblast heterotypic aggregates in malignant ascites of patients with ovarian cancer. 61
31638162 2019
McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation - a case report. 61
31852070 2019
Hemodynamic analysis of the recipient parasylvian cortical arteries for predicting postoperative hyperperfusion during STA-MCA bypass in adult patients with moyamoya disease. 61
31881540 2019
Idiopathic mast cell activation syndrome and radiation therapy: a case study, literature review, and discussion of mast cell disorders and radiotherapy. 61
31818306 2019
Functionality of Mozzarella cheese analogues prepared using varying protein sources as influenced by refrigerated storage. 61
31749471 2019
Symptoms of mast cell activation syndrome in functional gastrointestinal disorders. 61
31687861 2019
Asymmetrical than symmetrical cerebral arterial bifurcations are more vulnerable to aneurysm presence. 61
31748590 2019
A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients. 61
31108121 2019
Factors adversely influencing neurodevelopment. 61
31928596 2019
Semi-automated vs. manual 3D reconstruction of central mesenteric vascular models: the surgeon's verdict. 61
31745632 2019
Middle Cerebral Artery Plaque Hyperintensity on T2-Weighted Vessel Wall Imaging Is Associated with Ischemic Stroke. 61
31624115 2019
Trapping a Photoelectron behind a Repulsive Coulomb Barrier in Solution. 61
31498643 2019
Effects of GB34 acupuncture on hyperventilation-induced carbon dioxide reactivity and cerebral blood flow velocity in the anterior and middle cerebral arteries of normal subjects. 61
31412706 2019
Simple In-House Fabrication of Microwells for Generating Uniform Hepatic Multicellular Cancer Aggregates and Discovering Novel Therapeutics. 61
31614495 2019
AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management. 61
31476322 2019
Post-Lumbar Puncture Headache-Does Hydration before Puncture Prevent Headache and Affect Cerebral Blood Flow? 61
31627321 2019
Omalizumab Therapy for Mast Cell-Mediator Symptoms in Patients with ISM, CM, MMAS, and MCAS. 61
30954641 2019
Hepatic Encephalopathy Mimicking Acute Dominant Middle Cerebral Artery Ischemic Stroke: A Case Report. 61
31824285 2019
Multiobjective and Interactive Genetic Algorithms for Weight Tuning of a Model Predictive Control-Based Motion Cueing Algorithm. 61
29994690 2019
A Human-like Bile Acid Pool Induced by Deletion of Cyp2c70 Modulates Effects of Farnesoid X Receptor Activation in Mice. 61
31506275 2019
Qualitative study exploring the key determinants of information gathering to inform the management of over-the-counter (OTC) consultations in community pharmacies. 61
31420393 2019
A comparison of transcranial Doppler and magnetic resonance imaging for long term changes in middle cerebral artery stenosis. 61
31071500 2019
The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS). 61
31267471 2019
Successful mast-cell-targeted treatment of chronic dyspareunia, vaginitis, and dysfunctional uterine bleeding. 61
30964355 2019
Effect of hyperglycemia on cerebral blood flow in patients with diabetes. 61
31145928 2019
Quantifying and characterising multi-compartment compliance aid provision. 61
31477529 2019
Cerebrovascular function and mitochondrial bioenergetics after ischemia-reperfusion in male rats. 61
29215305 2019
Recognition and Management of Medication Excipient Reactivity in Patients With Mast Cell Activation Syndrome. 61
31126513 2019
Higher prevalence of vertebral fractures in systemic mastocytosis, but not in cutaneous mastocytosis and idiopathic mast cell activation syndrome. 61
30847528 2019
Acid sensing ion channels in rat cerebral arteries: Probing the expression pattern and vasomotor activity. 61
31026454 2019
Light-Trapping Engineering for the Enhancements of Broadband and Spectra-Selective Photodetection by Self-Assembled Dielectric Microcavity Arrays. 61
31147847 2019
Proximal Parent Vessel Tapering is Associated With Aneurysm at the Middle Cerebral Artery Bifurcation. 61
29846722 2019

Variations for Mast Cell Activation Syndrome

Expression for Mast Cell Activation Syndrome

Search GEO for disease gene expression data for Mast Cell Activation Syndrome.

Pathways for Mast Cell Activation Syndrome

GO Terms for Mast Cell Activation Syndrome

Sources for Mast Cell Activation Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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