MCID: MST004
MIFTS: 44

Mast Cell Neoplasm

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Mast Cell Neoplasm

MalaCards integrated aliases for Mast Cell Neoplasm:

Name: Mast Cell Neoplasm 12 15 73
Mastocytoma 12 55 73
Mast Cell Proliferative Disease 12
Benign Mastocytoma 73
Mast Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3664
ICD10 33 D47.09 C96.2
NCIt 50 C9295
SNOMED-CT 68 89796001

Summaries for Mast Cell Neoplasm

Disease Ontology : 12 A hematologic cancer that has material basis in mast cells.

MalaCards based summary : Mast Cell Neoplasm, also known as mastocytoma, is related to cutaneous solitary mastocytoma and extracutaneous mastocytoma. An important gene associated with Mast Cell Neoplasm is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and NF-kappaB Signaling. Affiliated tissues include t cells, bone and lymph node, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Mast Cell Neoplasm

Diseases related to Mast Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 cutaneous solitary mastocytoma 33.4 CD2 CMA1 KIT KITLG
2 extracutaneous mastocytoma 32.1 CD2 KIT
3 mast-cell leukemia 30.0 KIT KITLG
4 mastocytosis 30.0 CD2 HDC KIT KITLG
5 mastocytosis, cutaneous 29.7 CD2 CMA1 KIT KITLG
6 systemic mastocytosis 29.6 CD2 HDC KIT KITLG
7 cutaneous mastocytoma 12.7
8 benign mastocytoma 12.1
9 intra-abdominal lymph node mast cell malignancy 11.2
10 mast-cell sarcoma 11.1
11 maxillary sinus adenoid cystic carcinoma 10.2 IL2 KIT
12 ocular melanoma 10.2 IL2 KIT
13 sm-ahnmd 10.2 CD2 KIT
14 chronic conjunctivitis 10.2 CMA1 PTGER3
15 aggressive systemic mastocytosis 10.2 KIT KITLG
16 mucosal melanoma 10.2 IL2 KIT
17 immune defect due to absence of thymus 10.1 CD2 IL2
18 t-cell adult acute lymphocytic leukemia 10.1 CD2 IL2
19 ewing's family of tumors 10.1 KIT KITLG
20 dowling-degos disease 1 10.1 KIT KITLG
21 pigmentation disease 10.1 KIT KITLG
22 thymus gland disease 10.1 IL2 KIT
23 sclerosing cholangitis, neonatal 10.1
24 t cell deficiency 10.1 CD2 IL2
25 vernal conjunctivitis 10.1 CMA1 IL2
26 exanthema subitum 10.1 IL2 KITLG
27 leukocyte disease 10.1 CD2 IL2 KIT
28 thymoma 10.1 CD2 IL2 KIT
29 langerhans cell histiocytosis 10.0
30 melanoma 10.0
31 histiocytosis 10.0
32 influenza 10.0
33 lymphangiosarcoma 10.0 IL2 KITLG
34 lepromatous leprosy 10.0 CD2 IL2
35 indolent systemic mastocytosis 9.9 CD2 HDC KIT KITLG
36 hematologic cancer 9.9 CD2 IL2 KIT KITLG
37 leukemia, acute myeloid 9.9 CD2 IL2 KIT KITLG
38 testicular disease 9.9 IL2 KITLG
39 lymphosarcoma 9.9
40 prolidase deficiency 9.9
41 nuclear ribonucleic acid 9.9
42 leukotriene c4 synthase deficiency 9.9
43 dengue virus 9.9
44 hemangioma 9.9
45 hepatitis 9.9
46 hepatitis b 9.9
47 pertussis 9.9
48 angioedema 9.9
49 cellulitis 9.9
50 juvenile xanthogranuloma 9.9

Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to Mast Cell Neoplasm

Symptoms & Phenotypes for Mast Cell Neoplasm

GenomeRNAi Phenotypes related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 9.28 GCNT2
2 Decreased homologous recombination repair frequency GR00236-A-1 9.28 FBXO31 GCNT1 GCNT2 KITLG PTGER3
3 Decreased homologous recombination repair frequency GR00236-A-2 9.28 GCNT1 PTGER3
4 Decreased homologous recombination repair frequency GR00236-A-3 9.28 FBXO31

MGI Mouse Phenotypes related to Mast Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CMA1 GCNT1 GCNT2 GCNT4 HDC IL2
2 immune system MP:0005387 9.32 CMA1 GCNT1 GCNT2 GCNT4 HDC IL2

Drugs & Therapeutics for Mast Cell Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of TF002 in Cutaneous Mastocytosis Completed NCT00457288 Phase 2 TF 002
2 Natural History of Urticaria Pigmentosa in Children Completed NCT00467792
3 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Recruiting NCT02761473
4 Adaptation of the Questionnaire "Regarding Patient's Quality of Life With Mastocytosis" in the French Language Not yet recruiting NCT03632811
5 Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous Catheter Terminated NCT01616537 Not Applicable

Search NIH Clinical Center for Mast Cell Neoplasm

Genetic Tests for Mast Cell Neoplasm

Anatomical Context for Mast Cell Neoplasm

MalaCards organs/tissues related to Mast Cell Neoplasm:

41
T Cells, Bone, Lymph Node, Thymus, Spleen, Myeloid, Liver

Publications for Mast Cell Neoplasm

Articles related to Mast Cell Neoplasm:

(show top 50) (show all 491)
# Title Authors Year
1
Childhood solitary cutaneous mastocytoma: clinical manifestations, diagnosis, evaluation, and management. ( 30465511 )
2018
2
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. ( 28397975 )
2018
3
Pleomorphic mastocytoma in an adult. ( 29148588 )
2018
4
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279. ( 29463690 )
2018
5
Solitary mastocytoma in the eyelid of an adult. ( 29468227 )
2018
6
Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. ( 29710479 )
2018
7
Solitary mastocytoma presenting at birth. ( 29716178 )
2018
8
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma. ( 30356111 )
2018
9
The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma. ( 28580034 )
2017
10
Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma. ( 28918040 )
2017
11
Solitary mastocytoma with positive Darier's sign. ( 27057508 )
2016
12
Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations. ( 27802814 )
2016
13
Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway. ( 28127293 )
2016
14
Topical corticosteroids versus "wait and see" in the management of solitary mastocytoma in pediatric patients: a long-term follow-up. ( 25471152 )
2015
15
Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells. ( 24249003 )
2014
16
Bioengineering murine mastocytoma cells to produce anticoagulant heparin. ( 24326668 )
2014
17
Intramuscular electroporation of a P1A-encoding plasmid vaccine delays P815 mastocytoma growth. ( 24342164 )
2014
18
Cutaneous mast cell tumor (Mastocytoma): cyto- histopathological and haematological investigations. ( 24444100 )
2014
19
Role of lipid raft components and actin cytoskeleton in fibronectin-binding, surface expression, and de novo synthesis of integrin subunits in PGE2- or 8-Br-cAMP-stimulated mastocytoma P-815 cells. ( 24518258 )
2014
20
Solitary mastocytoma of the vulva. ( 24800094 )
2014
21
Case Report: Solitary mastocytoma treated successfully with topical tacrolimus. ( 25210620 )
2014
22
Solitary mastocytoma mimicking granuloma faciale. ( 25257118 )
2014
23
Solitary mastocytoma with associated pseudocarcinomatous hyperplasia. ( 23252514 )
2013
24
Intratumoural interleukin-2 therapy can induce regression of non-resectable mastocytoma in dogs. ( 23267141 )
2013
25
Behavior of the P1.HTR mastocytoma cell line implanted in the chorioallantoic membrane of chick embryos. ( 23314344 )
2013
26
Solitary mastocytoma of the eyelid. ( 23871296 )
2013
27
Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. ( 24072749 )
2013
28
Dermacase: Can you identify this condition? Solitary mastocytoma. ( 22977914 )
2012
29
NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation. ( 22583069 )
2012
30
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. ( 22677519 )
2012
31
Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. ( 22936666 )
2012
32
Induction of integrin β3 in PGE₂-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin. ( 21276770 )
2011
33
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. ( 21501463 )
2011
34
Solitary mastocytoma with histologic features of eosinophilic cellulites. ( 21540136 )
2011
35
Pathology quiz case 1. Pediatric solitary mastocytoma. ( 21768423 )
2011
36
Solitary mastocytoma in an adult with an unusual clinical presentation. ( 21839341 )
2011
37
A rare presentation of solitary mastocytoma in the palm of an infant. ( 19502121 )
2010
38
Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells. ( 19960020 )
2010
39
Mastocytoma in the common carpal sheath of the digital flexor tendons of a horse. ( 20148821 )
2010
40
Images for diagnosis. A vulva mastocytoma having grown for eighteen years. ( 20193267 )
2010
41
VEGF expression in dog mastocytoma. ( 20509299 )
2010
42
Growth of vascular smooth muscle cells on collagen I exposed to RBL-2H3 mastocytoma cells. ( 20511706 )
2010
43
PUFA-dependent alteration of oxidative parameters of a canine mastocytoma cell line. ( 21087915 )
2010
44
Characterization of an early signaling defect following Fc epsilonRI activation in the canine mastocytoma cell line, C2. ( 19135724 )
2009
45
Anti-cancer effect of two alkaloids: 2R and 2S-bgugaine on mastocytoma P815 and carcinoma Hep. ( 19401921 )
2009
46
Effect of radiation on vascular endothelial growth factor expression in the C2 canine mastocytoma cell line. ( 19719431 )
2009
47
Co-expression of P1A35-43/beta2m fusion protein and co-stimulatory molecule CD80 elicits effective anti-tumor immunity in the P815 mouse mastocytoma tumor model. ( 19787242 )
2009
48
Combined Mastocytoma-hemangioma in a Patient with Urticaria Pigmentosa. ( 27303182 )
2008
49
Adult onset, hypopigmented solitary mastocytoma: report of two cases. ( 18187823 )
2008
50
Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis. ( 18723263 )
2008

Variations for Mast Cell Neoplasm

Expression for Mast Cell Neoplasm

Search GEO for disease gene expression data for Mast Cell Neoplasm.

Pathways for Mast Cell Neoplasm

GO Terms for Mast Cell Neoplasm

Cellular components related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.92 GCNT1 GCNT2 GCNT4 NDST2

Biological processes related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 GCNT2 IL2 KIT KITLG
2 MAPK cascade GO:0000165 9.67 IL2 KIT KITLG
3 protein glycosylation GO:0006486 9.54 GCNT1 GCNT2 GCNT4
4 ovarian follicle development GO:0001541 9.52 KIT KITLG
5 glycosaminoglycan biosynthetic process GO:0006024 9.51 GCNT2 NDST2
6 positive regulation of protein kinase B signaling GO:0051897 9.5 GCNT2 KIT KITLG
7 T cell differentiation GO:0030217 9.48 IL2 KIT
8 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 IL2 KITLG
9 natural killer cell activation GO:0030101 9.4 CD2 IL2
10 embryonic hemopoiesis GO:0035162 9.26 KIT KITLG
11 kidney morphogenesis GO:0060993 9.16 GCNT1 GCNT4
12 ectopic germ cell programmed cell death GO:0035234 8.96 KIT KITLG
13 tissue morphogenesis GO:0048729 8.62 GCNT1 GCNT4

Molecular functions related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.5 GCNT1 GCNT2 GCNT4
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 IL2 KIT KITLG
3 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity GO:0003829 9.16 GCNT1 GCNT4
4 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity GO:0008109 8.96 GCNT2 GCNT4
5 acetylglucosaminyltransferase activity GO:0008375 8.8 GCNT1 GCNT2 GCNT4

Sources for Mast Cell Neoplasm

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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62 PubMed
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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