MCID: MST004
MIFTS: 42

Mast Cell Neoplasm

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Mast Cell Neoplasm

MalaCards integrated aliases for Mast Cell Neoplasm:

Name: Mast Cell Neoplasm 12 15 17 71
Mastocytoma 12 71
Mast Cell Proliferative Disease 12
Benign Mastocytoma 71
Mast Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3664
NCIt 49 C9295
SNOMED-CT 67 414653009
ICD10 32 D47.09
UMLS 71 C0024897 C0334664 C2242987

Summaries for Mast Cell Neoplasm

Disease Ontology : 12 A hematologic cancer that has material basis in mast cells.

MalaCards based summary : Mast Cell Neoplasm, also known as mastocytoma, is related to benign mastocytoma and cutaneous solitary mastocytoma. An important gene associated with Mast Cell Neoplasm is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Denosumab and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Mast Cell Neoplasm

Diseases related to Mast Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 benign mastocytoma 34.3 KIT CD2
2 cutaneous solitary mastocytoma 34.1 SERPINA3 KITLG KIT CMA1 CD2
3 mast-cell sarcoma 32.2 KITLG KIT FIP1L1 CMA1 CD2
4 extracutaneous mastocytoma 31.7 U2AF1 SRSF2 KITLG KIT FIP1L1 CD2
5 neutropenia 30.7 KITLG IL3 IL2 FLT3
6 myeloid sarcoma 30.7 U2AF1 KIT FLT3
7 mast-cell leukemia 30.5 U2AF1 KITLG KIT ATP7A
8 hypereosinophilic syndrome 30.3 KIT IL3 IL2 FIP1L1
9 cellulitis 30.0 SERPINA3 IL2 ICOSLG FLT3 CD8A CD4
10 dermatitis, atopic 29.8 SERPINA3 KITLG IL2 ICOSLG CMA1 CD8A
11 immune deficiency disease 29.7 SERPINA3 IL2 ICOSLG H2AC18 CD80 CD4
12 systemic mastocytosis 29.6 U2AF1 SRSF2 KITLG KIT HDC FIP1L1
13 skin disease 29.5 U2AF1 SERPINA3 IL2 ICOSLG H2AC18 CD8A
14 mastocytosis, cutaneous 29.5 KITLG KIT IL3 HDC FIP1L1 CMA1
15 severe combined immunodeficiency 29.5 KITLG KIT IL3 IL2 ICOSLG H2AC18
16 leukemia, chronic myeloid 29.3 U2AF1 KITLG KIT IL3 H2AC18 FLT3
17 mastocytosis 29.2 SRSF2 KITLG KIT IL3 HDC FLT3
18 aggressive systemic mastocytosis 28.7 U2AF1 SRSF2 KITLG KIT FLT3 FIP1L1
19 leukemia, acute myeloid 27.2 U2AF1 SRSF2 SERPINA3 KITLG KIT IL3
20 intra-abdominal lymph node mast cell malignancy 11.4
21 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.6 KIT FLT3
22 acute myeloblastic leukemia with maturation 10.5 KIT FLT3
23 malignant anus melanoma 10.5 KIT IL2
24 cork-handlers' disease 10.5 CD8A CD4
25 type c thymoma 10.5 SERPINA3 KIT
26 mixed cell type cancer 10.5 SERPINA3 KIT H2AC18
27 connective tissue benign neoplasm 10.5 SERPINA3 KIT H2AC18
28 tonsil cancer 10.5 SERPINA3 KIT H2AC18
29 ventilation pneumonitis 10.5 CD8A CD4
30 oropharynx cancer 10.5 SERPINA3 KIT H2AC18
31 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
32 skeletal muscle cancer 10.5 SERPINA3 KIT H2AC18
33 muscle cancer 10.5 SERPINA3 KIT H2AC18
34 diabetes mellitus, insulin-dependent, 23 10.5 CD8A CD4
35 systemic epstein-barr virus-positive t-cell lymphoma of childhood 10.5 CD8A CD2
36 autoimmune lymphoproliferative syndrome, type iia 10.5 CD8A CD4
37 germ cell and embryonal cancer 10.5 SERPINA3 KIT H2AC18
38 refractory cytopenia with multilineage dysplasia 10.4 U2AF1 ASXL1
39 early yaws 10.4 CD8A CD4
40 leukemia, acute monocytic 10.4 U2AF1 H2AC18 FLT3
41 immune-complex glomerulonephritis 10.4 ICOSLG H2AC18 CD4
42 toxicodendron dermatitis 10.4 IL2 CD8A
43 anus cancer 10.4 H2AC18 CD8A CD4
44 loeffler endocarditis 10.4 IL3 FIP1L1
45 intestinal obstruction 10.4 SERPINA3 KIT CD8A
46 combat disorder 10.4 SERPINA3 CD8A CD4
47 neutrophilia, hereditary 10.4 U2AF1 IL3 FLT3
48 capillary leak syndrome 10.4 IL2 ICOSLG CD8A
49 adult acute lymphocytic leukemia 10.4 CD8A CD4 CD2
50 central nervous system vasculitis 10.4 SERPINA3 CD8A CD4

Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to Mast Cell Neoplasm

Symptoms & Phenotypes for Mast Cell Neoplasm

MGI Mouse Phenotypes related to Mast Cell Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 ASXL1 CD4 CD80 CD8A FLT3 IL2
2 hematopoietic system MP:0005397 9.73 ASXL1 ATP7A CD4 CD80 CD8A CMA1
3 immune system MP:0005387 9.4 ASXL1 ATP7A CD4 CD80 CD8A CMA1

Drugs & Therapeutics for Mast Cell Neoplasm

Drugs for Mast Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 3 615258-40-7
2 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis Recruiting NCT03401060 Phase 3 Denosumab;Placebo
2 Efficacy and Safety of TF002 in Cutaneous Mastocytosis Completed NCT00457288 Phase 2 TF 002
3 Adaptation of the Questionnaire "Regarding Patient's Quality of Life With Mastocytosis" in the French Language Completed NCT03632811
4 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Active, not recruiting NCT02761473
5 Evaluation of the Improvement of Pigmented Skin Lesions in Patients With Mastocytosis After Performing 2 Sessions of Pigment Laser : Pilot Study Conducted at a Reference Centre Mastocytoses (LaserMasto) Not yet recruiting NCT04377828

Search NIH Clinical Center for Mast Cell Neoplasm

Genetic Tests for Mast Cell Neoplasm

Anatomical Context for Mast Cell Neoplasm

MalaCards organs/tissues related to Mast Cell Neoplasm:

40
T Cells, Skin, Bone, Spleen, Bone Marrow, Liver, Monocytes

Publications for Mast Cell Neoplasm

Articles related to Mast Cell Neoplasm:

(show top 50) (show all 1761)
# Title Authors PMID Year
1
Ultraviolet A1 phototherapy for the treatment of localized scleroderma. 61
32383187 2020
2
Possible Relationship between Long-Term Adverse Health Effects of Gonad-Removing Surgical Sterilization and Luteinizing Hormone in Dogs. 61
32244716 2020
3
Reflectance confocal microscopy as a diagnostic tool for mastocytoma in children. 61
32276049 2020
4
Role of Zinc Sulphate in Immune Regulation in Artemisia annua Pollen-challenged P815 Mastocytoma Cells. 61
31913054 2020
5
Dermoscopic findings of a congenital smooth muscle hamartoma in an infant. 61
31840858 2020
6
Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma. 61
32181155 2020
7
Solitary Bullous Mastocytoma with Dermoscopic Features in a Neonate. 61
31723467 2019
8
Reactive Oxygen Species-Mediated Apoptosis and Cytotoxicity of Newly Synthesized Pyridazin-3-Ones In P815 (Murin Mastocytoma) Cell Line. 61
31252433 2019
9
Corrigendum: The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. 61
31397543 2019
10
The upregulation of Pim kinases is essential in coordinating the survival, proliferation, and migration of KIT D816V-mutated neoplastic mast cells. 61
31203104 2019
11
Immunophenotype of pediatric-onset mastocytosis does not correlate with clinical course. 61
31120154 2019
12
Cutaneous mastocytoma associated with abundant eosinophil infiltration and flame figures. 61
31034654 2019
13
Perioperative anaphylaxis in a patient with a solitary mastocytoma. 61
30854701 2019
14
[Isolated mastocytoma in children: a case study]. 61
31143350 2019
15
Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management. 61
30465511 2019
16
Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco. 61
30661057 2019
17
Paediatric mastocytosis: long-term follow-up of 53 patients with whole sequencing of KIT. A prospective study. 61
29787623 2018
18
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma. 61
30356111 2018
19
Incorporation, intracellular trafficking and processing of extracellular heparanase by mast cells: Involvement of syndecan-4-dependent pathway. 61
30149916 2018
20
Cutaneous Mastocytosis in Adults and Children: New Classification and Prognostic Factors. 61
30007456 2018
21
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. 61
29779048 2018
22
Solitary mastocytoma presenting at birth. 61
29716178 2018
23
Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients. 61
29803387 2018
24
Dermoscopy of Cutaneous Mastocytoma. 61
29854655 2018
25
Use of intralesional blood to determine diffusible biomarkers from skin lesions. 61
29366526 2018
26
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279. 61
29463690 2018
27
Solitary mastocytoma in the eyelid of an adult. 61
29468227 2018
28
Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. 61
29710479 2018
29
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. 61
28397975 2018
30
Reconstitution of a ligand-binding competent murine NKp30 receptor. 61
28782088 2018
31
Pleomorphic mastocytoma in an adult. 61
29148588 2018
32
Biotin conjugated organic molecules and proteins for cancer therapy: A review. 61
29324341 2018
33
Cellular effects of a turmeric root and rosemary leaf extract on canine neoplastic cell lines. 61
29237458 2017
34
IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells. 61
27507155 2017
35
Natural history and treatment of cutaneous and systemic mastocytosis. 61
28770635 2017
36
Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma. 61
28918040 2017
37
The role of serum tryptase in the diagnosis and monitoring of pediatric mastocytosis: a single-center experience. 61
28951704 2017
38
R634W KIT Mutation in an Adult With Systemic Mastocytosis. 61
28520972 2017
39
New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity. 61
28574833 2017
40
Differential Cytotoxic Activity of Essential Oil of Lippia citriodora from Different Regions in Morocco. 61
28317320 2017
41
Estimating canine cancer incidence: findings from a population-based tumour registry in northwestern Italy. 61
28659149 2017
42
Effect of H4R antagonist N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamides and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole on histamine and 4-methylhistamine-induced mast cell response. 61
27807993 2017
43
Recent clinical trials of cancer immunogene therapy in companion animals. 61
28589078 2017
44
Rare cause of recurrent urticaria in childhood and its unusual presentation: Solitary mastocytoma on vulva. 61
27206703 2017
45
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization. 61
27716898 2017
46
The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma. 61
28580034 2017
47
Familial Progressive Hyperpigmentation, Cutaneous Mastocytosis, and Gastrointestinal Stromal Tumor as Clinical Manifestations of Mutations in the c-KIT Receptor Gene. 61
27981619 2017
48
Solitary Mastocytoma of the Eyelid in an Adult Patient With Prolidase Deficiency. 61
25603535 2017
49
Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model. 61
28713380 2017
50
Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils. 61
27999175 2016

Variations for Mast Cell Neoplasm

Expression for Mast Cell Neoplasm

Search GEO for disease gene expression data for Mast Cell Neoplasm.

Pathways for Mast Cell Neoplasm

Pathways related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 SERPINA3 KITLG KIT IL3 IL2 ICOSLG
2
Show member pathways
13.4 KITLG KIT IL3 IL2 FLT3 CD80
3
Show member pathways
13.23 KITLG KIT IL3 IL2 FLT3 CD80
4
Show member pathways
13.23 KITLG KIT IL3 IL2 FLT3 CD80
5
Show member pathways
13.14 KITLG KIT IL3 IL2 CD80 CD4
6 12.72 KITLG KIT IL3 IL2 FLT3
7
Show member pathways
12.68 IL3 IL2 ICOSLG CD8A CD80 CD4
8 12.36 KITLG KIT IL3 IL2 CD8A CD2
9
Show member pathways
12.27 IL2 ICOSLG CD80 CD4
10
Show member pathways
12.24 KITLG KIT IL3 IL2 FLT3
11 11.82 ICOSLG CD8A CD80 CD4 CD2
12 11.64 KITLG KIT CD4
13 11.61 KIT IL2 CD8A CD4
14 11.56 CD8A CD80 CD4
15 11.5 KITLG KIT IL3 FLT3 CD8A CD4
16 11.42 KIT IL2 FLT3 CD8A CD4
17 11.37 KITLG KIT IL3
18 11.34 KITLG KIT IL3 IL2 FLT3 CD8A
19 11.33 IL2 CD80 CD4
20 11.07 IL3 IL2 CD4
21 10.77 KITLG KIT IL3 IL2 FLT3 CD80

GO Terms for Mast Cell Neoplasm

Cellular components related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 KIT ICOSLG CD8A CD80 CD4 CD2

Biological processes related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 KITLG KIT IL3 IL2 FLT3
2 immune response GO:0006955 9.96 IL3 IL2 CD8A CD80 CD4
3 MAPK cascade GO:0000165 9.8 KITLG KIT IL3 IL2 FLT3
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.73 KIT FLT3 CD8A CD4
5 hemopoiesis GO:0030097 9.72 KIT FLT3 ASXL1
6 positive regulation of MAP kinase activity GO:0043406 9.71 KITLG KIT FLT3
7 positive regulation of T cell proliferation GO:0042102 9.7 IL2 CD80 CD4
8 mRNA 3'-end processing GO:0031124 9.67 U2AF1 SRSF2 FIP1L1
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 KITLG IL3 CD80 CD4
10 T cell differentiation GO:0030217 9.63 KIT IL2 CD4
11 positive regulation of kinase activity GO:0033674 9.62 KIT IL2 FLT3 CD4
12 ectopic germ cell programmed cell death GO:0035234 9.51 KITLG KIT
13 myeloid progenitor cell differentiation GO:0002318 9.48 KIT FLT3
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 KIT IL3 IL2 FLT3
15 embryonic hemopoiesis GO:0035162 9.43 KITLG KIT IL3
16 cytokine-mediated signaling pathway GO:0019221 9.43 KIT IL3 IL2 FLT3 CD80 CD4
17 T cell activation GO:0042110 8.92 ICOSLG CD8A CD4 CD2

Molecular functions related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.8 CD8A CD80 CD4

Sources for Mast Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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