MCID: MST004
MIFTS: 38

Mast Cell Neoplasm

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Mast Cell Neoplasm

MalaCards integrated aliases for Mast Cell Neoplasm:

Name: Mast Cell Neoplasm 12 15 17 71
Mastocytoma 12 71
Mast Cell Proliferative Disease 12
Benign Mastocytoma 71
Mast Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3664
NCIt 49 C9295
SNOMED-CT 67 89796001
ICD10 32 D47.09
UMLS 71 C0024897 C0334664 C2242987

Summaries for Mast Cell Neoplasm

Disease Ontology : 12 A hematologic cancer that has material basis in mast cells.

MalaCards based summary : Mast Cell Neoplasm, also known as mastocytoma, is related to cutaneous solitary mastocytoma and extracutaneous mastocytoma. An important gene associated with Mast Cell Neoplasm is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). The drugs Denosumab and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and skin.

Related Diseases for Mast Cell Neoplasm

Diseases related to Mast Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 cutaneous solitary mastocytoma 34.1 SERPINA3 KITLG KIT CMA1 CD2
2 extracutaneous mastocytoma 32.6 U2AF1 KITLG KIT CD2
3 mast-cell sarcoma 32.5 KITLG KIT CMA1 CD2
4 systemic mastocytosis 30.8 KITLG KIT HDC CD2
5 mastocytosis 30.8 KITLG KIT HDC CD2
6 mast-cell leukemia 30.6 U2AF1 KITLG KIT ATP7A
7 cellulitis 30.5 ICOSLG CD8A CD4
8 aggressive systemic mastocytosis 30.3 KITLG KIT CD2 ATP7A
9 leukemia, chronic myeloid 30.0 U2AF1 KITLG KIT H2AC18 CD8A
10 severe combined immunodeficiency 30.0 KITLG KIT IL2 ICOSLG H2AC18 CD4
11 combined t cell and b cell immunodeficiency 29.9 IL2 ICOSLG H2AC18 CD8A CD4
12 mastocytosis, cutaneous 29.9 SERPINA3 KITLG KIT HDC CMA1 CD2
13 skin disease 29.7 SERPINA3 IL2 ICOSLG H2AC18 CD8A CD4
14 dermatitis, atopic 29.5 SERPINA3 KITLG IL2 ICOSLG H2AC18 CMA1
15 leukemia, acute myeloid 28.7 U2AF1 SERPINA3 KITLG KIT IL2 ICOSLG
16 benign mastocytoma 12.3
17 intra-abdominal lymph node mast cell malignancy 11.4
18 type c thymoma 10.6 SERPINA3 KIT
19 mixed cell type cancer 10.5 SERPINA3 KIT H2AC18
20 tonsil cancer 10.5 SERPINA3 KIT H2AC18
21 oropharynx cancer 10.5 SERPINA3 KIT H2AC18
22 skeletal muscle cancer 10.5 SERPINA3 KIT H2AC18
23 muscle cancer 10.5 SERPINA3 KIT H2AC18
24 cork-handlers' disease 10.5 CD8A CD4
25 syphilitic meningitis 10.5 CD8A CD4
26 plasma cell neoplasm 10.5 SERPINA3 ICOSLG CD8A
27 chronic leukemia 10.5 U2AF1 KIT H2AC18
28 ventilation pneumonitis 10.5 CD8A CD4
29 intestinal obstruction 10.5 SERPINA3 KIT CD8A
30 breast malignant phyllodes tumor 10.5 SERPINA3 KIT
31 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
32 dengue disease 10.5 ICOSLG H2AC18 CD8A
33 autoimmune lymphoproliferative syndrome, type iia 10.5 CD8A CD4
34 lethal midline granuloma 10.5 SERPINA3 CD2
35 toxicodendron dermatitis 10.4 IL2 CD8A
36 immune-complex glomerulonephritis 10.4 ICOSLG H2AC18 CD4
37 chromosome 14q11-q22 deletion syndrome 10.4 CD8A CD4
38 autoimmune disease of skin and connective tissue 10.4 SERPINA3 ICOSLG CD4
39 diabetes mellitus, insulin-dependent, 23 10.4 CD8A CD4
40 capillary leak syndrome 10.4 IL2 ICOSLG CD8A
41 chronic conjunctivitis 10.4 ICOSLG CMA1 CD4
42 combined thymoma 10.4 KIT CD8A CD4
43 dysgerminoma of ovary 10.4 KITLG KIT
44 bird fancier's lung 10.4 CD8A CD4
45 early yaws 10.4 CD8A CD4
46 cyclosporiasis 10.4 SERPINA3 CD4
47 dacryoadenitis 10.4 ICOSLG CD8A CD4
48 polyclonal hypergammaglobulinemia 10.4 SERPINA3 CD8A CD4
49 immunodeficiency with hyper-igm, type 3 10.4 ICOSLG CD8A CD4
50 central nervous system vasculitis 10.4 SERPINA3 CD8A CD4

Graphical network of the top 20 diseases related to Mast Cell Neoplasm:



Diseases related to Mast Cell Neoplasm

Symptoms & Phenotypes for Mast Cell Neoplasm

Drugs & Therapeutics for Mast Cell Neoplasm

Drugs for Mast Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 3 615258-40-7
2 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis Recruiting NCT03401060 Phase 3 Denosumab;Placebo
2 Efficacy and Safety of TF002 in Cutaneous Mastocytosis Completed NCT00457288 Phase 2 TF 002
3 Adaptation of the Questionnaire "Regarding Patient's Quality of Life With Mastocytosis" in the French Language Completed NCT03632811
4 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Active, not recruiting NCT02761473

Search NIH Clinical Center for Mast Cell Neoplasm

Genetic Tests for Mast Cell Neoplasm

Anatomical Context for Mast Cell Neoplasm

MalaCards organs/tissues related to Mast Cell Neoplasm:

40
T Cells, Bone, Skin, Lung, Bone Marrow, Myeloid, Spleen

Publications for Mast Cell Neoplasm

Articles related to Mast Cell Neoplasm:

(show top 50) (show all 1757)
# Title Authors PMID Year
1
Dermoscopic findings of a congenital smooth muscle hamartoma in an infant. 61
31840858 2020
2
Role of Zinc Sulphate in Immune Regulation in Artemisia annua Pollen-challenged P815 Mastocytoma Cells. 61
31913054 2020
3
Solitary Bullous Mastocytoma with Dermoscopic Features in a Neonate. 61
31723467 2019
4
Reactive Oxygen Species-Mediated Apoptosis and Cytotoxicity of Newly Synthesized Pyridazin-3-Ones In P815 (Murin Mastocytoma) Cell Line. 61
31252433 2019
5
Corrigendum: The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. 61
31397543 2019
6
The upregulation of Pim kinases is essential in coordinating the survival, proliferation, and migration of KIT D816V-mutated neoplastic mast cells. 61
31203104 2019
7
Immunophenotype of pediatric-onset mastocytosis does not correlate with clinical course. 61
31120154 2019
8
Cutaneous mastocytoma associated with abundant eosinophil infiltration and flame figures. 61
31034654 2019
9
Perioperative anaphylaxis in a patient with a solitary mastocytoma. 61
30854701 2019
10
Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco. 61
30661057 2019
11
[Isolated mastocytoma in children: a case study]. 61
31143350 2019
12
Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management. 61
30465511 2019
13
Paediatric mastocytosis: long-term follow-up of 53 patients with whole sequencing of KIT. A prospective study. 61
29787623 2018
14
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma. 61
30356111 2018
15
Incorporation, intracellular trafficking and processing of extracellular heparanase by mast cells: Involvement of syndecan-4-dependent pathway. 61
30149916 2018
16
Cutaneous Mastocytosis in Adults and Children: New Classification and Prognostic Factors. 61
30007456 2018
17
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. 61
29779048 2018
18
Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients. 61
29803387 2018
19
Solitary mastocytoma presenting at birth. 61
29716178 2018
20
Dermoscopy of Cutaneous Mastocytoma. 61
29854655 2018
21
Use of intralesional blood to determine diffusible biomarkers from skin lesions. 61
29366526 2018
22
Reconstitution of a ligand-binding competent murine NKp30 receptor. 61
28782088 2018
23
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279. 61
29463690 2018
24
Solitary mastocytoma in the eyelid of an adult. 61
29468227 2018
25
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. 61
28397975 2018
26
Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. 61
29710479 2018
27
Pleomorphic mastocytoma in an adult. 61
29148588 2018
28
Biotin conjugated organic molecules and proteins for cancer therapy: A review. 61
29324341 2018
29
IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells. 61
27507155 2017
30
Cellular effects of a turmeric root and rosemary leaf extract on canine neoplastic cell lines. 61
29237458 2017
31
Natural history and treatment of cutaneous and systemic mastocytosis. 61
28770635 2017
32
Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma. 61
28918040 2017
33
The role of serum tryptase in the diagnosis and monitoring of pediatric mastocytosis: a single-center experience. 61
28951704 2017
34
R634W KIT Mutation in an Adult With Systemic Mastocytosis. 61
28520972 2017
35
Differential Cytotoxic Activity of Essential Oil of Lippia citriodora from Different Regions in Morocco. 61
28317320 2017
36
New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity. 61
28574833 2017
37
Effect of H4R antagonist N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamides and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole on histamine and 4-methylhistamine-induced mast cell response. 61
27807993 2017
38
Estimating canine cancer incidence: findings from a population-based tumour registry in northwestern Italy. 61
28659149 2017
39
Recent clinical trials of cancer immunogene therapy in companion animals. 61
28589078 2017
40
Rare cause of recurrent urticaria in childhood and its unusual presentation: Solitary mastocytoma on vulva. 61
27206703 2017
41
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization. 61
27716898 2017
42
Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model. 61
28713380 2017
43
The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma. 61
28580034 2017
44
Solitary Mastocytoma of the Eyelid in an Adult Patient With Prolidase Deficiency. 61
25603535 2017
45
Familial Progressive Hyperpigmentation, Cutaneous Mastocytosis, and Gastrointestinal Stromal Tumor as Clinical Manifestations of Mutations in the c-KIT Receptor Gene. 61
27981619 2017
46
Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils. 61
27999175 2016
47
Science Signaling Podcast for 20 December 2016: Trans-inhibition by Fc receptors. 61
27999172 2016
48
[Diffuse cutaneous mastocytosis of an infant: A case report]. 61
27670724 2016
49
Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations. 61
27802814 2016
50
Well-differentiated systemic mastocytosis showed excellent clinical response to imatinib in the absence of known molecular genetic abnormalities: A case report. 61
27741105 2016

Variations for Mast Cell Neoplasm

Expression for Mast Cell Neoplasm

Search GEO for disease gene expression data for Mast Cell Neoplasm.

Pathways for Mast Cell Neoplasm

GO Terms for Mast Cell Neoplasm

Cellular components related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 VPREB1 SERPINA3 KITLG KIT IL2 H2BC21
2 external side of plasma membrane GO:0009897 9.35 KIT ICOSLG CD8A CD4 CD2
3 extracellular region GO:0005576 9.32 VPREB1 SERPINA3 KITLG ISM2 ISM1 IL2

Biological processes related to Mast Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ectopic germ cell programmed cell death GO:0035234 9.26 KITLG KIT
2 catecholamine biosynthetic process GO:0042423 9.16 HDC DBH
3 T cell differentiation GO:0030217 9.13 KIT IL2 CD4
4 T cell activation GO:0042110 8.92 ICOSLG CD8A CD4 CD2

Sources for Mast Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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