MCID: MST001
MIFTS: 37

Mast-Cell Sarcoma

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Mast-Cell Sarcoma

MalaCards integrated aliases for Mast-Cell Sarcoma:

Name: Mast-Cell Sarcoma 12 44 15 73
Mast Cell Sarcoma 59

Characteristics:

Orphanet epidemiological data:

59
mast cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:355
ICD10 33 C96.2
ICD9CM 35 202.6
MeSH 44 D012515
NCIt 50 C9348
Orphanet 59 ORPHA66661
ICD10 via Orphanet 34 C96.2
MESH via Orphanet 45 D012515
UMLS via Orphanet 74 C0036221
UMLS 73 C0036221

Summaries for Mast-Cell Sarcoma

MalaCards based summary : Mast-Cell Sarcoma, also known as mast cell sarcoma, is related to sarcoma and mediastinal cancer. An important gene associated with Mast-Cell Sarcoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic cell lineage and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and bone, and related phenotypes are splenomegaly and weight loss

Wikipedia : 76 Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma... more...

Related Diseases for Mast-Cell Sarcoma

Diseases related to Mast-Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 sarcoma 10.5
2 mediastinal cancer 10.3 ANPEP KIT
3 vascular cancer 10.2 ANPEP KIT
4 malignant mixed mullerian tumor 10.1 KIT VIM
5 benign breast phyllodes tumor 10.1 KIT VIM
6 senile angioma 10.1 KIT VIM
7 perivascular epithelioid cell tumor 10.1 KIT VIM
8 perineurioma 10.1 KIT VIM
9 dermoid cyst 10.1 KIT VIM
10 embryonal sarcoma 10.1 KIT VIM
11 smooth muscle tumor 10.1 KIT VIM
12 polymorphous low-grade adenocarcinoma 10.1 KIT VIM
13 fibromatosis 10.0 KIT VIM
14 cavernous hemangioma 10.0 KIT VIM
15 neurilemmoma 10.0 KIT VIM
16 angiosarcoma 10.0 KIT VIM
17 oncocytoma 10.0 KIT VIM
18 dermatofibrosarcoma protuberans 10.0 KIT VIM
19 inflammatory myofibroblastic tumor 9.9 KIT VIM
20 sarcoma, synovial 9.9 KIT VIM
21 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9 KIT MPO
22 leiomyosarcoma 9.9 KIT VIM
23 malignant peripheral nerve sheath tumor 9.8 KIT VIM
24 leukemia 9.8
25 systemic mastocytosis 9.8
26 sertoli cell tumor 9.8
27 histiocytoma 9.8
28 seminoma 9.8
29 small intestinal sarcoma 9.8
30 lymphosarcoma 9.8
31 germ cells tumors 9.8
32 endometrial stromal sarcoma 9.8 KIT VIM
33 aleukemic leukemia cutis 9.8 ANPEP MPO
34 mast cell disease 9.8 KIT MPO
35 leiomyoma 9.7 KIT VIM
36 dendritic cell tumor 9.7 MPO VIM
37 leukemia, acute lymphoblastic 3 9.6 ANPEP MPO
38 pericardial mesothelioma 9.6 MPO VIM
39 adenoid cystic carcinoma 9.5 KIT VIM
40 precursor t-cell acute lymphoblastic leukemia 9.3 ANPEP MPO
41 gastrointestinal stromal tumor 9.3 KIT VIM
42 myeloid sarcoma 9.3 ANPEP KIT MPO
43 acute leukemia 9.3 ANPEP KIT MPO
44 bone marrow cancer 9.3 ANPEP KIT MPO
45 leukemia, acute myeloid 9.2 ANPEP KIT MPO

Graphical network of the top 20 diseases related to Mast-Cell Sarcoma:



Diseases related to Mast-Cell Sarcoma

Symptoms & Phenotypes for Mast-Cell Sarcoma

Human phenotypes related to Mast-Cell Sarcoma:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
2 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
3 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
4 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
5 sarcoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0100242
6 mastocytosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100495
7 hypoplasia of the ear cartilage 59 32 frequent (33%) Frequent (79-30%) HP:0100720
8 mediastinal lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0100721
9 lymphadenopathy 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.17 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.17 KIT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.17 VIM
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.17 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.17 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.17 KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.17 MPO KIT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.17 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.17 PRKG2 MPO VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.17 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.17 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.17 PRKG2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.17 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.17 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.17 PRKG2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.17 MPO VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.17 VIM KIT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.17 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.17 KIT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.17 PRKG2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-44 10.17 PRKG2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.17 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.17 VIM
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.17 MPO
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.17 MPO
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.17 VIM KIT PRKG2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.17 KIT
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.17 KIT

Drugs & Therapeutics for Mast-Cell Sarcoma

Drugs for Mast-Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Anti-Allergic Agents Phase 3
4 Antipruritics Phase 3
5 Dermatologic Agents Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11 Serotonin Agents Phase 3
12 Serotonin Antagonists Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous Catheter Terminated NCT01616537 Not Applicable

Search NIH Clinical Center for Mast-Cell Sarcoma

Cochrane evidence based reviews: mast-cell sarcoma

Genetic Tests for Mast-Cell Sarcoma

Anatomical Context for Mast-Cell Sarcoma

MalaCards organs/tissues related to Mast-Cell Sarcoma:

41
Skin, Colon, Bone, Uterus, Small Intestine, Bone Marrow

Publications for Mast-Cell Sarcoma

Articles related to Mast-Cell Sarcoma:

(show all 29)
# Title Authors Year
1
The first report of human primary thoracic spine mast cell sarcoma: a case report. ( 28992848 )
2018
2
Mast cell sarcoma of the sternum, clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation. ( 28236058 )
2017
3
Anaplastic mast cell sarcoma: a unique pathologic entity in mastocytosis. ( 27808598 )
2016
4
Mast cell sarcoma: new cases and literature review. ( 27602777 )
2016
5
Mast cell sarcoma: clinical management. ( 24745684 )
2014
6
Mast cell sarcoma in an infant: a case report and review of the literature. ( 23211696 )
2013
7
Mast cell sarcoma: a rare and aggressive entity--report of two cases and review of the literature. ( 23129735 )
2013
8
Pediatric mast cell sarcoma of temporal bone with novel L799F (2395 C>T) KIT mutation, mimicking histiocytic neoplasm. ( 23388130 )
2013
9
Mast cell sarcoma mimicking metastatic colon carcinoma. ( 24141335 )
2013
10
Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications. ( 23196796 )
2013
11
Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis? ( 22963840 )
2012
12
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. ( 22498828 )
2012
13
Mast cell sarcoma with megakaryocytic differentiation in a calf. ( 22813945 )
2012
14
Mast cell sarcoma of the small intestine: a case report. ( 21778298 )
2011
15
Successful treatment of mast cell sarcoma of the uterus with imatinib. ( 22020400 )
2011
16
Mast-cell sarcoma of the tibia. ( 17405977 )
2007
17
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. ( 12801524 )
2003
18
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma. ( 12826896 )
2003
19
Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy. ( 11216707 )
2001
20
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. ( 10430280 )
1999
21
What is your diagnosis? Mast cell sarcoma. ( 9097238 )
1997
22
[Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]. ( 9273545 )
1997
23
Brief communication, Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat. ( 8736393 )
1996
24
Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog. ( 3145930 )
1988
25
Mast cell sarcoma of the larynx. ( 3088063 )
1986
26
Mast cell sarcoma of the larynx in a dog: a case report. ( 104092 )
1979
27
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. ( 13306668 )
1956
28
Preliminary observations on the use of cortisone in canine mast cell sarcoma. ( 13108793 )
1953
29
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. ( 18118928 )
1948

Variations for Mast-Cell Sarcoma

Expression for Mast-Cell Sarcoma

Search GEO for disease gene expression data for Mast-Cell Sarcoma.

Pathways for Mast-Cell Sarcoma

Pathways related to Mast-Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 ANPEP KIT
2 11.2 ANPEP KIT MPO
3 10.88 ANPEP KIT
4 10.69 ANPEP KIT MPO

GO Terms for Mast-Cell Sarcoma

Sources for Mast-Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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