MCID: MST005
MIFTS: 57

Mastitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Mastitis

MalaCards integrated aliases for Mastitis:

Name: Mastitis 12 55 44 15 73
Inflammation of Non-Human Mammary Gland 73
Inflammatory Disorder of Breast 73
Inflammatory Disease of Breast 12
Inflammatory Breast Disease 12
Breast Inflammation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10690
MeSH 44 D008413
NCIt 50 C53662
SNOMED-CT 68 45198002
ICD10 33 N61

Summaries for Mastitis

Disease Ontology : 12 A breast disease characterized by painful infection of the breast tissue.

MalaCards based summary : Mastitis, also known as inflammation of non-human mammary gland, is related to toxic shock syndrome and arthritis, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hydrocortisone acetate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and neutrophil, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...

Related Diseases for Mastitis

Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 32.4 CXCL8 IL6 TLR2
2 arthritis 30.1 NOD2 IL6 IL17A CXCL8 CSF2
3 pneumonia 30.0 CCL5 CXCL8 IL6 TLR2
4 mycobacterium kansasii 29.9 CXCL8 TLR2
5 acute cystitis 29.9 ALB CXCL8 IL6
6 endometritis 29.9 HP IL6 OXT
7 meningitis 29.8 TLR2 IL6 CXCL8 ALB
8 endocarditis 29.7 TLR2 LBP IL6 CXCL8 ALB
9 peritonitis 29.7 TLR2 LBP IL6 CXCL8 ALB
10 systemic lupus erythematosus 29.5 ALB CCL5 CXCL8 IL17A IL6 TLR2
11 rheumatoid arthritis 29.1 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
12 granulomatous mastitis 12.6
13 granulomatous lobular mastitis 12.5
14 neonatal infective mastitis 12.2
15 eosinophilic mastitis 12.2
16 breast abscess 11.4
17 inflammatory breast carcinoma 11.4
18 diabetic mastopathy 11.4
19 breast cancer 10.3
20 mycobacterium chelonae 10.3 CXCL8 TLR2
21 mycobacterium marinum 10.3 CXCL8 TLR2
22 scorpion envenomation 10.3 CCL5 IL6
23 haemophilus influenzae 10.2 CXCL8 LTF TLR2
24 recurrent corneal erosion 10.2 CXCL8 IL6
25 bagassosis 10.2 CXCL8 IL6
26 pouchitis 10.2 CXCL8 LTF NOD2
27 meningitis and encephalitis 10.2 ALB CP
28 middle ear disease 10.2 CXCL8 IL6 TLR2
29 keratoconjunctivitis sicca 10.2 ALB IL6 LTF
30 aggressive periodontitis 10.2 CXCL8 IL6 LTF
31 bacterial vaginosis 10.2 CXCL8 IL6 TLR2
32 leptospirosis 10.2 CXCL8 IL6 TLR2
33 acute pyelonephritis 10.2 ALB CXCL8 IL6
34 obesity-hypoventilation syndrome 10.2 CCL5 IL6
35 pyelonephritis 10.2 ALB CXCL8 IL6
36 hemorrhagic fever with renal syndrome 10.2 ALB CXCL8 IL6
37 viral meningitis 10.2 IL6 CXCL8 CCL5
38 periodontitis, chronic 10.2 IL6 TLR2
39 neurosyphilis 10.2 CXCL8 IL17A TLR2
40 dengue hemorrhagic fever 10.2 ALB CXCL8 IL6
41 infective endocarditis 10.2 IL6 LBP TLR2
42 felty syndrome 10.2 LTF CXCL8 CSF2
43 obstructive jaundice 10.2 ALB CXCL8 IL6
44 acute generalized exanthematous pustulosis 10.2 CXCL8 IL17A
45 transverse myelitis 10.2 IL6 IL17A CXCL8
46 acute transverse myelitis 10.2 CXCL8 IL6
47 gastroenteritis 10.2 ALB CXCL8 IL6
48 mycoplasma pneumoniae pneumonia 10.2 TLR2 IL6 IL17A
49 visceral leishmaniasis 10.2 ALB CXCL8 TLR2
50 q fever 10.2 IL6 NOD2 TLR2

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis

Symptoms & Phenotypes for Mastitis

UMLS symptoms related to Mastitis:


signs and symptoms in breast

GenomeRNAi Phenotypes related to Mastitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.32 LBP
2 Decreased viability GR00381-A-1 9.32 CSN3 LBP LTF
3 Decreased viability GR00381-A-3 9.32 CSN3 LBP LTF
4 Decreased viability GR00402-S-2 9.32 CSN3 LBP LTF

MGI Mouse Phenotypes related to Mastitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 CCL5 CP CSF2 CXCL6 HP IL17A
2 homeostasis/metabolism MP:0005376 10.17 ALB CP CSF2 CXCL6 HP IL17A
3 endocrine/exocrine gland MP:0005379 10.1 ALB CSF2 CSN2 CSN3 IL17A IL6
4 immune system MP:0005387 10.07 CCL5 CP CSF2 CXCL6 HP IL17A
5 adipose tissue MP:0005375 9.91 CP CSF2 IL6 OXT STAT5A TLR2
6 integument MP:0010771 9.76 CSF2 CSN2 CSN3 IL6 LALBA OXT
7 liver/biliary system MP:0005370 9.56 ALB CP HP IL6 LBP LTF
8 renal/urinary system MP:0005367 9.17 ALB CSF2 HP IL17A IL6 OXT

Drugs & Therapeutics for Mastitis

Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
3 Hydrocortisone 17-butyrate 21-propionate Phase 4
4 Cortisol succinate Phase 4
5 Dermatologic Agents Phase 4
6 Hydrocortisone-17-butyrate Phase 4
7 Anti-Inflammatory Agents Phase 4
8
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
9
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
10
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
11
Azithromycin Approved Phase 3 83905-01-5 55185 447043
12 Acidophilus Phase 2, Phase 3,Phase 1,Not Applicable
13 beta-Lactamase Inhibitors Phase 2, Phase 3
14 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
15 Antitubercular Agents Phase 2, Phase 3
16 Anti-Bacterial Agents Phase 2, Phase 3,Not Applicable
17 Clavulanic Acids Phase 2, Phase 3
18 beta-Lactams Phase 2, Phase 3
19 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Not Applicable
20 Lactams Phase 2, Phase 3
21 Antioxidants Phase 3,Phase 2
22 Trace Elements Phase 3,Phase 2
23 Micronutrients Phase 3,Phase 2
24 Protective Agents Phase 3,Phase 2
25 Propolis Phase 3
26 Bee Products Phase 3
27
Tocopherol Approved, Investigational Phase 2 1406-66-2 14986
28
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
29
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
30 Tocotrienol Investigational Phase 2 6829-55-6
31 Vitamins Phase 2
32 Tocotrienols Phase 2
33 Tocopherols Phase 2
34 Vasodilator Agents Phase 2
35 Free Radical Scavengers Phase 2
36 Phosphodiesterase Inhibitors Phase 2
37 Radiation-Protective Agents Phase 2
38 Platelet Aggregation Inhibitors Phase 2
39
Methotrexate Approved 59-05-2, 1959-05-2 126941
40
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
41
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 439302 53477758
42
Acetaminophen Approved Not Applicable 103-90-2 1983
43
Nicotinamide Approved, Investigational 98-92-0 936
44
Methylcobalamin Approved, Experimental, Investigational 13422-55-4
45
leucovorin Approved 58-05-9 6006 143
46
Hydroxocobalamin Approved 13422-51-0 11953898 44475014
47
Milk thistle Approved, Experimental, Investigational Not Applicable 65666-07-1
48
Lidocaine Approved, Vet_approved ,Not Applicable 137-58-6 3676
49
Ceftriaxone Approved ,Not Applicable 73384-59-5 5479530 5361919
50
Triamcinolone Approved, Vet_approved ,Not Applicable 124-94-7 31307

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Medical and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
2 Local Steroid Treatment for Idiopathic Granulomatous Mastitis (LSTIGM) Not yet recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
3 Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
4 Partnership on Nutrition and HIV/AIDS Research in Tanzania: Exploratory Research Study on Selenium and HIV Infection Completed NCT00197561 Phase 3
5 The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis Recruiting NCT03756324 Phase 2, Phase 3 CHPM (Chinese Herbal Patent Medicine );Antibiotics Cefdinir Capsules
6 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
7 Use of Bee Wax Mammary Areolae to Improve Breastfeeding Recruiting NCT03676608 Phase 3
8 Study of a Probiotic Strain to Prevent Mastitis and to Eradicate GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
9 The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants Recruiting NCT03310853 Phase 2
10 The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain Terminated NCT00188669 Phase 2 pentoxifylline;alpha-Tocopherol
11 Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
12 Granulomatous Mastitis Current Approach and Treatment Completed NCT02667132
13 Evaluation of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Completed NCT02203877 Not Applicable
14 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis Completed NCT00620984
15 Global Effects of a Probiotic Strain on Lactating Women Completed NCT01124448 Not Applicable
16 Study of Acupuncture and Care Interventions for the Treatment of Breast Inflammation During Breastfeeding Completed NCT00405158 Not Applicable Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
17 Nursing Education Intervention for Maternal Breastfeeding Completed NCT02106026 Not Applicable
18 Painful Breastfeeding and Bacterial or Yeast Infection Completed NCT01631461
19 L.Fermentum CECT5716 in Treatment of Breast Pain Completed NCT02093338 Not Applicable
20 Impact of Mothers Touch Program to Improve Maternal Health After Birth Completed NCT03715218 Not Applicable
21 Vitamins, Breastmilk HIV Shedding, and Child Health Completed NCT00197756
22 Impact of Maternal Stress on Infant Stunting Completed NCT02755012
23 New Protocol for Febrile Neonate Management Completed NCT03183531
24 Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy Completed NCT01479478 Not Applicable Placebo
25 Evaluation of Accelerated Partial Breast Brachytherapy Completed NCT00593346 Not Applicable
26 Acupuncture for Breast Engorgement During Lactation Recruiting NCT03230760 Not Applicable
27 Breastfeeding Success With the Use of the WHO Syringe Technique for Management of Inverted Nipples in Lactating Women Recruiting NCT03529630 Not Applicable
28 Efficacy of Herbal Galactagogue Silitidil After Preterm Birth Recruiting NCT03577587 Not Applicable
29 Ductal Lavage in Non-lactating Female Women With Mastitis Active, not recruiting NCT02794688
30 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis Not yet recruiting NCT03724903 Not Applicable Corticosteroid therapy
31 Puncture Breast Abscess Not yet recruiting NCT03730467
32 Intervention Zambia Rural L&D Infection Study Not yet recruiting NCT03809741 Not Applicable

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

MalaCards organs/tissues related to Mastitis:

41
Breast, Testes, Neutrophil, Bone, Liver, Pituitary, Lung

Publications for Mastitis

Articles related to Mastitis:

(show top 50) (show all 1770)
# Title Authors Year
1
High-Risk Factors for Suppurative Mastitis in Lactating Women. ( 29916453 )
2018
2
Tolerance to bovine clinical mastitis: Total, direct, and indirect milk losses. ( 29395137 )
2018
3
Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial. ( 29374099 )
2018
4
Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-I_B p65, ERK1/2 and P38 Signaling Pathway. ( 29904013 )
2018
5
Addition of meloxicam to the treatment of bovine clinical mastitis results in a net economic benefit to the dairy farmer. ( 29398019 )
2018
6
Molecular Characterization and Clonal Diversity of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates of Milk of Cows with Clinical Mastitis in Tunisia. ( 29373088 )
2018
7
Diagnosis of bovine mastitis: from laboratory to farm. ( 29948774 )
2018
8
Molecular characterization and antimicrobial susceptibility pattern of Streptococcus agalactiae isolated from clinical mastitis in dairy cattle. ( 29928042 )
2018
9
Idiopathic lobular granulomatous mastitis: radiological management in two cases. ( 29793678 )
2018
10
Synergism of Plant Compound With Traditional Antimicrobials Against <i>Streptococcus</i> spp. Isolated From Bovine Mastitis. ( 29928266 )
2018
11
The Effect of Some Natural Essential Oils Against Bovine Mastitis Caused by Prototheca zopfii Isolates In Vitro. ( 29380186 )
2018
12
Comparative plasma and interstitial fluid pharmacokinetics and tissue residues of ceftiofur crystalline-free acid in cattle with induced coliform mastitis. ( 29971798 )
2018
13
Short communication: Lack of intramammary niche recolonization during a sanitation program for the contagious mastitis pathogen Staphylococcus aureus genotype B. ( 29908812 )
2018
14
Scoring Idiopathic Granulomatous Mastitis: An Effective System for Predicting Recurrence? ( 29774320 )
2018
15
Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 <i>(AKT3)</i> Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis. ( 29862252 )
2018
16
Infectious and Inflammatory Breast Disease. ( 29298955 )
2018
17
Genomic investigation of Staphylococcus aureus isolates from bulk tank milk and dairy cows with clinical mastitis. ( 29426404 )
2018
18
Idiopathic Granulomatous Mastitis: Manifestations at Multimodality Imaging and Pitfalls. ( 29528819 )
2018
19
Corynebacterium kroppenstedtii in granulomatous mastitis: Analysis of formalin-fixed, paraffin-embedded biopsy specimens by immunostaining using low-specificity bacterial antisera and real-time polymerase chain reaction. ( 29862601 )
2018
20
Is erythema nodosum coexisting with lesions of the breast a suggestive sign for idiopathic granulomatous mastitis? ( 29756114 )
2018
21
Biofilm-Forming Potential of Staphylococcus aureus Isolated from Clinical Mastitis Cases in New Zealand. ( 29351199 )
2018
22
Diagnosis and Treatment of 75 Patients with Idiopathic Lobular Granulomatous Mastitis. ( 29381437 )
2018
23
Response to Paricio-Talayero and Baeza re: &amp;quot;Oral Administration to Nursing Women of Lactobacillus fermentum CECT5716 Prevents Lactational Mastitis Development: A Randomized Controlled Trial&amp;quot;. ( 29897789 )
2018
24
Association of subclinical mastitis prevalence with sheep breeds in Greece. ( 29925444 )
2018
25
Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of autoinducer 2. ( 29397176 )
2018
26
<i>Staphylococcus aureus</i> Isolates from Bovine Mastitis in Eight Countries: Genotypes, Detection of Genes Encoding Different Toxins and Other Virulence Genes. ( 29914197 )
2018
27
A pilot study of acute phase proteins as indicators of bovine mastitis caused by different pathogens. ( 29945037 )
2018
28
Subclinical mastitis (SCM) and proinflammatory cytokines are associated with mineral and trace element concentrations in human breast milk. ( 29413111 )
2018
29
The microbiology and treatment of human mastitis. ( 29350290 )
2018
30
Herd-Level Mastitis-Associated Costs on Canadian Dairy Farms. ( 29868620 )
2018
31
Advantages of b-mode ultrasound combined with strain elastography in differentiation of idiopathic granulomatous mastitis from malignant breast lesions ( 29479939 )
2018
32
Granulomatous Mastitis Concurrence with Breast Cancer. ( 29322122 )
2018
33
Repurposing Ionophores as novel antimicrobial agents for the treatment of bovine mastitis caused by Gram-positive pathogens. ( 29971788 )
2018
34
Impact of subclinical mastitis on greenhouse gas emissions intensity and profitability of dairy cows in Norway. ( 29406080 )
2018
35
Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis. ( 29398026 )
2018
36
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
37
Detection of tetracycline and other antimicrobial residues in milk from cows with clinical mastitis treated by combination therapy. ( 29969084 )
2018
38
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Streptococcus dysgalactiae isolated from bovine clinical mastitis in 5 provinces of China. ( 29397161 )
2018
39
Prevalence of mastitis pathogens in South African pasture-based and total mixed ration-based dairies during 2008 and 2013. ( 29943584 )
2018
40
The effect of pegylated granulocyte colony-stimulating factor treatment prior to experimental mastitis in lactating Holsteins. ( 29885891 )
2018
41
Pathogenesis and inflammatory response in experimental caprine mastitis due to Staphylococcus chromogenes. ( 29360565 )
2018
42
Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. ( 29971624 )
2018
43
Mastitis on Rabbit Farms: Prevalence and Risk Factors. ( 29925797 )
2018
44
A case report of TB versus idiopathic granulomatous mastitis with erythema nodosum, reactive arthritis, cough, and headache. ( 30293476 )
2018
45
Best-practice care pathway for improving management of mastitis and breast abscess. ( 29993125 )
2018
46
Immunogenicity of a Staphylococcus aureus-cholera toxin A2/B vaccine for bovine mastitis. ( 29739718 )
2018
47
Case Report: Ductal Carcinoma in Situ Within A Granulomatous Mastitis. ( 30123886 )
2018
48
Mitral Kissing Vegetation and Acquired Aortic Valve Stenosis Secondary to Infectious Endocarditis in a Goat with Suppurative Mastitis. ( 29996509 )
2018
49
A very rare case of eosinophilic mastitis. ( 30055479 )
2018
50
Granulomatous Lobular Mastitis: Clinicopathologic Presentation of 90 Cases ( 29744854 )
2018

Variations for Mastitis

Expression for Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for Mastitis

Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CCL5 CSF2 CXCL8 HP IL17A IL6
2
Show member pathways
13.31 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
3
Show member pathways
13.24 CCL5 CSF2 CXCL8 IL17A IL6 LBP
4
Show member pathways
13 CCL5 CSF2 CXCL8 IL6 STAT5A TLR2
5
Show member pathways
12.96 CCL5 CXCL8 IL6 LBP NOD2 TLR2
6
Show member pathways
12.73 CCL5 CXCL8 IL6 STAT5A TLR2
7
Show member pathways
12.5 IL17A IL6 NOD2 STAT5A TLR2
8 12.17 IL6 LBP NOD2 TLR2
9
Show member pathways
12.16 CP CXCL8 IL6 TLR2
10
Show member pathways
12.13 CSF2 CXCL6 CXCL8 IL17A IL6 TLR2
11
Show member pathways
12.12 CXCL8 IL6 LBP TLR2
12
Show member pathways
11.96 IL17A IL6 STAT5A TLR2
13 11.87 CXCL8 IL17A IL6 LBP
14 11.84 CCL5 CSF2 IL6 NOD2
15 11.82 CXCL8 IL6 STAT5A
16 11.76 CSF2 CXCL8 IL6 TLR2
17 11.7 CXCL6 CXCL8 IL6
18 11.69 CSF2 CXCL8 IL6 LBP
19
Show member pathways
11.61 CSF2 CXCL8 IL6
20 11.59 CCL5 CSF2 IL17A IL6
21 11.54 CXCL8 IL6 TLR2
22 11.5 CCL5 CSF2 CXCL8 IL6
23 11.47 CXCL8 IL6 TLR2
24 11.47 CSF2 CSN2 CXCL8 IL6 STAT5A
25 11.45 CSF2 IL6 STAT5A
26 11.43 CXCL8 IL6 STAT5A
27
Show member pathways
11.4 CSF2 CXCL6 CXCL8 IL17A IL6 LBP
28 11.36 CCL5 CSF2 CXCL8 IL6
29 11.12 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
30 10.96 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
31 10.92 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6

GO Terms for Mastitis

Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 ALB CCL5 CP CSF2 CSN2 CSN3
2 extracellular space GO:0005615 9.55 ALB CCL5 CP CSF2 CSN2 CSN3
3 specific granule lumen GO:0035580 9.33 HP LTF SLPI

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.94 CCL5 CXCL6 IL17A LALBA
2 cellular protein metabolic process GO:0044267 9.93 ALB CP IL6 LTF
3 response to lipopolysaccharide GO:0032496 9.91 CXCL6 LBP SLPI TLR2
4 inflammatory response GO:0006954 9.91 CCL5 CXCL6 CXCL8 IL17A IL6 TLR2
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL6 LTF NOD2 TLR2
6 defense response GO:0006952 9.87 CXCL6 CXCL8 HP NOD2
7 regulation of signaling receptor activity GO:0010469 9.87 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
8 neutrophil chemotaxis GO:0030593 9.84 CCL5 CXCL6 CXCL8
9 cellular response to interleukin-1 GO:0071347 9.83 CCL5 CXCL8 IL17A
10 cellular oxidant detoxification GO:0098869 9.83 ALB HP LPO
11 chemokine-mediated signaling pathway GO:0070098 9.81 CCL5 CXCL6 CXCL8
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 CCL5 CSF2 IL6
13 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.8 CXCL6 CXCL8 LTF
14 defense response to Gram-positive bacterium GO:0050830 9.8 IL6 LALBA LBP TLR2
15 positive regulation of tumor necrosis factor production GO:0032760 9.79 LBP NOD2 TLR2
16 defense response to Gram-negative bacterium GO:0050829 9.78 IL6 LALBA LBP LTF
17 lactation GO:0007595 9.76 CSN2 CSN3 STAT5A
18 immune response GO:0006955 9.76 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
19 negative regulation of viral genome replication GO:0045071 9.73 CCL5 LTF SLPI
20 cellular response to lipopolysaccharide GO:0071222 9.73 CSF2 CXCL6 CXCL8 IL6 LBP NOD2
21 acute-phase response GO:0006953 9.72 HP IL6 LBP
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL5 LBP TLR2
23 positive regulation of interleukin-6 production GO:0032755 9.71 IL6 LBP NOD2 TLR2
24 positive regulation of interleukin-8 production GO:0032757 9.69 LBP NOD2 TLR2
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 NOD2 TLR2
26 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.67 CCL5 CXCL8
27 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 TLR2
28 cellular response to lipoteichoic acid GO:0071223 9.65 LBP TLR2
29 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.65 LBP LTF
30 positive regulation of chemokine production GO:0032722 9.63 IL6 LBP TLR2
31 negative regulation of macrophage apoptotic process GO:2000110 9.62 CCL5 NOD2
32 negative regulation of cysteine-type endopeptidase activity GO:2000117 9.6 CSN2 LTF
33 positive regulation of interleukin-23 production GO:0032747 9.59 CSF2 IL17A
34 neutrophil activation GO:0042119 9.54 CCL5 CXCL6 CXCL8
35 cytokine secretion involved in immune response GO:0002374 9.52 NOD2 TLR2
36 cytokine-mediated signaling pathway GO:0019221 9.5 CCL5 CSF2 CXCL8 IL17A IL6 LBP
37 defense response to bacterium GO:0042742 9.23 CXCL6 HP LALBA LBP LPO LTF

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL5 CXCL6 CXCL8
2 lipopeptide binding GO:0071723 9.26 LBP TLR2
3 lipopolysaccharide binding GO:0001530 9.13 LBP LTF TLR2
4 cytokine activity GO:0005125 9.1 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6

Sources for Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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