MCID: MST005
MIFTS: 55

Mastitis

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Mastitis

MalaCards integrated aliases for Mastitis:

Name: Mastitis 12 55 44 15 73
Inflammation of Non-Human Mammary Gland 73
Inflammatory Disorder of Breast 73
Inflammatory Disease of Breast 12
Inflammatory Breast Disease 12
Breast Inflammation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10690
MeSH 44 D008413
NCIt 50 C53662
ICD10 33 N61

Summaries for Mastitis

MalaCards based summary : Mastitis, also known as inflammation of non-human mammary gland, is related to toxic shock syndrome and mycobacterium kansasii, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hydrocortisone and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, neutrophil and breast, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...

Related Diseases for Mastitis

Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 32.8 CXCL8 IL6 TLR2
2 mycobacterium kansasii 30.5 CXCL8 TLR2
3 pneumonia 30.4 CCL5 CXCL8 IL6 TLR2
4 conjunctivitis 30.1 CXCL8 ICAM1 IL6
5 meningitis 30.0 ALB CXCL8 IL6 TLR2
6 arthritis 29.7 CSF2 CXCL8 IL17A IL6
7 endometritis 29.5 HP IL6 OXT
8 uveitis 29.5 ICAM1 IL17A NOD2
9 psoriasis 29.0 CCL5 CXCL8 ICAM1 IL17A IL6
10 peritonitis 28.9 ALB CXCL8 ICAM1 IL6 LBP TLR2
11 granulomatous mastitis 12.4
12 granulomatous lobular mastitis 12.4
13 neonatal infective mastitis 12.1
14 eosinophilic mastitis 12.0
15 breast abscess 11.3
16 inflammatory breast carcinoma 11.2
17 diabetic mastopathy 11.2
18 mycobacterium chelonae 10.9 CXCL8 TLR2
19 scorpion envenomation 10.8 CCL5 IL6
20 recurrent corneal erosion 10.8 CXCL8 IL6
21 haemophilus influenzae 10.8 CXCL8 LTF TLR2
22 bagassosis 10.8 CXCL8 IL6
23 vaginal disease 10.7 CXCL8 IL6 SLPI
24 pouchitis 10.7 CXCL8 LTF NOD2
25 meningitis and encephalitis 10.7 ALB CP
26 bacterial vaginosis 10.7 CXCL8 IL6 TLR2
27 keratoconjunctivitis sicca 10.7 ALB IL6 LTF
28 leptospirosis 10.7 CXCL8 IL6 TLR2
29 gingivitis 10.7 CXCL8 IL6 LTF
30 obesity-hypoventilation syndrome 10.7 CCL5 IL6
31 acute cystitis 10.7 ALB CXCL8 IL6
32 acute pyelonephritis 10.7 ALB CXCL8 IL6
33 infective endocarditis 10.7 IL6 LBP TLR2
34 toxicodendron dermatitis 10.6 CXCL8 ICAM1
35 neurosyphilis 10.6 CXCL8 IL17A TLR2
36 viral meningitis 10.6 CCL5 CXCL8 IL6
37 pyelonephritis 10.6 ALB CXCL8 IL6
38 dengue hemorrhagic fever 10.6 ALB CXCL8 IL6
39 viral encephalitis 10.6 CCL5 CXCL8 IL6
40 chlamydia 10.6 CXCL8 IL6 TLR2
41 transverse myelitis 10.6 CXCL8 IL17A IL6
42 obstructive jaundice 10.6 ALB CXCL8 IL6
43 acute generalized exanthematous pustulosis 10.6 CXCL8 IL17A
44 bronchitis 10.6 ALB CXCL8 SLPI
45 gastroenteritis 10.6 ALB CXCL8 IL6
46 meningoencephalitis 10.6 ALB CCL5 IL6
47 periodontitis, chronic 10.6 IL6 TLR2
48 acute monoblastic leukemia 10.6 CSF2 CXCL8 IL6
49 meconium aspiration syndrome 10.5 CSF2 CXCL8 IL6
50 periapical granuloma 10.5 CCL5 CP CXCL8

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis

Symptoms & Phenotypes for Mastitis

UMLS symptoms related to Mastitis:


signs and symptoms in breast

MGI Mouse Phenotypes related to Mastitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 SLPI STAT5A TLR2 LBP LTF NOD2
2 homeostasis/metabolism MP:0005376 10.24 SLPI STAT5A TLR2 LBP LTF NOD2
3 endocrine/exocrine gland MP:0005379 10.17 OXT STAT5A TLR2 CSN2 IL6 CSN3
4 immune system MP:0005387 10.17 SLPI STAT5A TLR2 LBP LTF NOD2
5 digestive/alimentary MP:0005381 10 OXT TLR2 NOD2 IL6 ALB ICAM1
6 integument MP:0010771 9.91 OXT STAT5A TLR2 CSF2 CSN2 IL6
7 liver/biliary system MP:0005370 9.76 STAT5A TLR2 LBP LTF IL6 HP
8 neoplasm MP:0002006 9.5 TLR2 LTF CSF2 IL6 HP ALB
9 renal/urinary system MP:0005367 9.17 OXT TLR2 CSF2 IL6 HP ALB

Drugs & Therapeutics for Mastitis

Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
2
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
3
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
4 Cortisol succinate Phase 4
5 Hydrocortisone 17-butyrate 21-propionate Phase 4
6 Hydrocortisone acetate Phase 4
7
Histamine Phosphate Phase 4 51-74-1 65513
8 Neurotransmitter Agents Phase 4
9 Histamine Antagonists Phase 4
10 Dermatologic Agents Phase 4
11 Hydrocortisone-17-butyrate Phase 4
12 Anti-Inflammatory Agents Phase 4
13
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
14
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
15
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
16
Azithromycin Approved Phase 3 83905-01-5 55185 447043
17 Clavulanic Acid Phase 2, Phase 3
18 Micronutrients Phase 3,Phase 2
19 Trace Elements Phase 3,Phase 2
20 Anti-Bacterial Agents Phase 2, Phase 3,Not Applicable
21 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
22 Anti-Infective Agents Phase 2, Phase 3,Not Applicable
23 Lactams Phase 2, Phase 3
24 Antioxidants Phase 3,Phase 2
25 Protective Agents Phase 3,Phase 2
26 Antitubercular Agents Phase 2, Phase 3
27 beta-Lactamase Inhibitors Phase 2, Phase 3
28 beta-Lactams Phase 2, Phase 3
29 Acidophilus Nutraceutical Phase 2, Phase 3,Phase 1,Not Applicable
30
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
31
Tocopherol Approved, Investigational, Nutraceutical Phase 2 1406-66-2 14986
32
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
33 Tocopherols Phase 2
34 Tocotrienols Phase 2
35 Vitamins Phase 2
36 Vasodilator Agents Phase 2
37 Phosphodiesterase Inhibitors Phase 2
38 Platelet Aggregation Inhibitors Phase 2
39 Radiation-Protective Agents Phase 2
40 Tocotrienol Investigational, Nutraceutical Phase 2 6829-55-6
41
Menthol Approved Not Applicable 2216-51-5 16666
42
Hydroxocobalamin Approved 13422-51-0 11953898 44475014
43
Methotrexate Approved 1959-05-2, 59-05-2 126941
44
Acetaminophen Approved Not Applicable 103-90-2 1983
45
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
46
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 439302 53477758
47
Lidocaine Approved, Vet_approved 137-58-6 3676
48
Ceftriaxone Approved 73384-59-5 5479530 5361919
49
Triamcinolone Approved, Vet_approved 124-94-7 31307
50
Nicotinamide Approved, Investigational, Nutraceutical 98-92-0 936

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Medical and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
2 Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
3 Partnership on Nutrition and HIV/AIDS Research in Tanzania: Exploratory Research Study on Selenium and HIV Infection Completed NCT00197561 Phase 3
4 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
5 Study of a Probiotic Strain to Prevent Mastitis and to Eradicate GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
6 The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants Recruiting NCT03310853 Phase 2
7 The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain Terminated NCT00188669 Phase 2 pentoxifylline;alpha-Tocopherol
8 Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
9 Granulomatous Mastitis Current Approach and Treatment Completed NCT02667132
10 Evaluation of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Completed NCT02203877 Not Applicable
11 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis Completed NCT00620984
12 Global Effects of a Probiotic Strain on Lactating Women Completed NCT01124448 Not Applicable
13 Study of Acupuncture and Care Interventions for the Treatment of Breast Inflammation During Breastfeeding Completed NCT00405158 Not Applicable Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
14 Nursing Education Intervention for Maternal Breastfeeding Completed NCT02106026 Not Applicable
15 Painful Breastfeeding and Bacterial or Yeast Infection Completed NCT01631461
16 L.Fermentum CECT5716 in Treatment of Breast Pain Completed NCT02093338 Not Applicable
17 Vitamins, Breastmilk HIV Shedding, and Child Health Completed NCT00197756
18 Impact of Maternal Stress on Infant Stunting Completed NCT02755012
19 New Protocol for Febrile Neonate Management Completed NCT03183531
20 Evaluation of Accelerated Partial Breast Brachytherapy Completed NCT00593346 Not Applicable
21 Acupuncture for Breast Engorgement During Lactation Recruiting NCT03230760 Not Applicable
22 Breastfeeding Success With the Use of the WHO Syringe Technique for Management of Inverted Nipples in Lactating Women Recruiting NCT03529630 Not Applicable
23 Efficacy of Herbal Galactagogue Silitidil After Preterm Birth Recruiting NCT03577587 Not Applicable
24 Ductal Lavage in Non-lactating Female Women With Mastitis Active, not recruiting NCT02794688

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

MalaCards organs/tissues related to Mastitis:

41
Testes, Neutrophil, Breast, Colon, Pituitary, Liver, Lymph Node

Publications for Mastitis

Articles related to Mastitis:

(show top 50) (show all 1022)
# Title Authors Year
1
High-Risk Factors for Suppurative Mastitis in Lactating Women. ( 29916453 )
2018
2
Tolerance to bovine clinical mastitis: Total, direct, and indirect milk losses. ( 29395137 )
2018
3
Comparative effectiveness of individualised homeopathy and antibiotics in the treatment of bovine clinical mastitis: randomised controlled trial. ( 29374099 )
2018
4
Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-I_B p65, ERK1/2 and P38 Signaling Pathway. ( 29904013 )
2018
5
Addition of meloxicam to the treatment of bovine clinical mastitis results in a net economic benefit to the dairy farmer. ( 29398019 )
2018
6
Molecular Characterization and Clonal Diversity of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates of Milk of Cows with Clinical Mastitis in Tunisia. ( 29373088 )
2018
7
Diagnosis of bovine mastitis: from laboratory to farm. ( 29948774 )
2018
8
Molecular characterization and antimicrobial susceptibility pattern of Streptococcus agalactiae isolated from clinical mastitis in dairy cattle. ( 29928042 )
2018
9
Idiopathic lobular granulomatous mastitis: radiological management in two cases. ( 29793678 )
2018
10
Synergism of Plant Compound With Traditional Antimicrobials Against <i>Streptococcus</i> spp. Isolated From Bovine Mastitis. ( 29928266 )
2018
11
The Effect of Some Natural Essential Oils Against Bovine Mastitis Caused by Prototheca zopfii Isolates In Vitro. ( 29380186 )
2018
12
Comparative plasma and interstitial fluid pharmacokinetics and tissue residues of ceftiofur crystalline-free acid in cattle with induced coliform mastitis. ( 29971798 )
2018
13
Short communication: Lack of intramammary niche recolonization during a sanitation program for the contagious mastitis pathogen Staphylococcus aureus genotype B. ( 29908812 )
2018
14
Scoring Idiopathic Granulomatous Mastitis: An Effective System for Predicting Recurrence? ( 29774320 )
2018
15
Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 <i>(AKT3)</i> Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis. ( 29862252 )
2018
16
Infectious and Inflammatory Breast Disease. ( 29298955 )
2018
17
Genomic investigation of Staphylococcus aureus isolates from bulk tank milk and dairy cows with clinical mastitis. ( 29426404 )
2018
18
Idiopathic Granulomatous Mastitis: Manifestations at Multimodality Imaging and Pitfalls. ( 29528819 )
2018
19
Corynebacterium kroppenstedtii in granulomatous mastitis: Analysis of formalin-fixed, paraffin-embedded biopsy specimens by immunostaining using low-specificity bacterial antisera and real-time polymerase chain reaction. ( 29862601 )
2018
20
Is erythema nodosum coexisting with lesions of the breast a suggestive sign for idiopathic granulomatous mastitis? ( 29756114 )
2018
21
Biofilm-Forming Potential of Staphylococcus aureus Isolated from Clinical Mastitis Cases in New Zealand. ( 29351199 )
2018
22
Diagnosis and Treatment of 75 Patients with Idiopathic Lobular Granulomatous Mastitis. ( 29381437 )
2018
23
Response to Paricio-Talayero and Baeza re: &amp;quot;Oral Administration to Nursing Women of Lactobacillus fermentum CECT5716 Prevents Lactational Mastitis Development: A Randomized Controlled Trial&amp;quot;. ( 29897789 )
2018
24
Association of subclinical mastitis prevalence with sheep breeds in Greece. ( 29925444 )
2018
25
Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of autoinducer 2. ( 29397176 )
2018
26
<i>Staphylococcus aureus</i> Isolates from Bovine Mastitis in Eight Countries: Genotypes, Detection of Genes Encoding Different Toxins and Other Virulence Genes. ( 29914197 )
2018
27
A pilot study of acute phase proteins as indicators of bovine mastitis caused by different pathogens. ( 29945037 )
2018
28
Subclinical mastitis (SCM) and proinflammatory cytokines are associated with mineral and trace element concentrations in human breast milk. ( 29413111 )
2018
29
The microbiology and treatment of human mastitis. ( 29350290 )
2018
30
Herd-Level Mastitis-Associated Costs on Canadian Dairy Farms. ( 29868620 )
2018
31
Advantages of b-mode ultrasound combined with strain elastography in differentiation of idiopathic granulomatous mastitis from malignant breast lesions ( 29479939 )
2018
32
Granulomatous Mastitis Concurrence with Breast Cancer. ( 29322122 )
2018
33
Repurposing Ionophores as novel antimicrobial agents for the treatment of bovine mastitis caused by Gram-positive pathogens. ( 29971788 )
2018
34
Impact of subclinical mastitis on greenhouse gas emissions intensity and profitability of dairy cows in Norway. ( 29406080 )
2018
35
Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis. ( 29398026 )
2018
36
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
37
Detection of tetracycline and other antimicrobial residues in milk from cows with clinical mastitis treated by combination therapy. ( 29969084 )
2018
38
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Streptococcus dysgalactiae isolated from bovine clinical mastitis in 5 provinces of China. ( 29397161 )
2018
39
Prevalence of mastitis pathogens in South African pasture-based and total mixed ration-based dairies during 2008 and 2013. ( 29943584 )
2018
40
The effect of pegylated granulocyte colony-stimulating factor treatment prior to experimental mastitis in lactating Holsteins. ( 29885891 )
2018
41
Pathogenesis and inflammatory response in experimental caprine mastitis due to Staphylococcus chromogenes. ( 29360565 )
2018
42
Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. ( 29971624 )
2018
43
Mastitis on Rabbit Farms: Prevalence and Risk Factors. ( 29925797 )
2018
44
Antibacterial activity of selected medicinal plants of northwest Pakistan traditionally used against mastitis in livestock. ( 29379373 )
2018
45
Indirect enzyme-linked immunosorbent assay method based on Streptococcus agalactiae rSip-Pgk-FbsA fusion protein for detection of bovine mastitis. ( 28865212 )
2017
46
Gastrointestinal trichostrongylosis can predispose ewes to clinical mastitis after experimental mammary infection. ( 28969841 )
2017
47
Rifampicin for Idiopathic Granulomatous Lobular Mastitis: A Promising Alternative for Treatment. ( 28050664 )
2017
48
Steroids administered after vacuum-assisted biopsy in the management of idiopathic granulomatous mastitis. ( 28931582 )
2017
49
Differentiation between idiopathic granulomatous mastitis and malignant breast lesions using strain ratio on ultrasonic elastography. ( 28729183 )
2017
50
The role of staphylococci in subclinical mastitis of cows and lytic phage isolation against to<i>Staphylococcus aureus</i>. ( 29391690 )
2017

Variations for Mastitis

Expression for Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for Mastitis

Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 CCL5 CSF2 CXCL8 HP ICAM1 IL17A
2
Show member pathways
13.34 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
3
Show member pathways
13.27 CCL5 CSF2 CXCL8 ICAM1 IL17A IL6
4
Show member pathways
12.98 CCL5 CXCL8 IL6 LBP NOD2 TLR2
5
Show member pathways
12.73 CCL5 CXCL8 ICAM1 IL6 STAT5A TLR2
6
Show member pathways
12.58 CSF2 CXCL8 IL17A IL6 STAT5A
7
Show member pathways
12.45 CSF2 CXCL8 ICAM1 IL6 STAT5A TLR2
8
Show member pathways
12.4 IL17A IL6 NOD2 STAT5A TLR2
9 12.37 CSF2 ICAM1 IL6 STAT5A
10
Show member pathways
12.28 ALB CCL5 ICAM1 IL6
11
Show member pathways
12.22 IL17A IL6 STAT5A TLR2
12 12.19 IL6 LBP NOD2 TLR2
13
Show member pathways
12.17 CP CXCL8 IL6 TLR2
14
Show member pathways
12.14 CXCL8 IL6 LBP TLR2
15
Show member pathways
12.13 CSF2 CXCL6 CXCL8 IL17A IL6 TLR2
16
Show member pathways
12.03 CCL5 CXCL8 ICAM1 IL17A IL6
17 11.86 CXCL8 ICAM1 IL17A IL6 LBP
18 11.85 CXCL8 ICAM1 IL6 STAT5A
19 11.83 CSF2 CXCL8 IL6 TLR2
20 11.82 CXCL8 ICAM1 LBP
21 11.8 CCL5 CSF2 ICAM1 IL6 NOD2
22 11.76 CSF2 CXCL8 IL6 LBP
23 11.71 CXCL6 CXCL8 IL6
24 11.6 CCL5 CSF2 CXCL8 IL6
25
Show member pathways
11.58 CSF2 CXCL8 ICAM1 IL6
26 11.55 CXCL8 IL6 TLR2
27 11.55 CSF2 CSN2 CXCL8 ICAM1 IL6 STAT5A
28 11.47 HP ICAM1 IL6
29
Show member pathways
11.47 CSF2 CXCL6 CXCL8 ICAM1 IL17A IL6
30 11.46 CSF2 IL6 STAT5A
31 11.45 CXCL8 IL6 STAT5A
32 11.42 CXCL8 ICAM1 IL6 TLR2
33 11.34 CCL5 CSF2 CXCL8 ICAM1 IL6
34 11.18 CCL5 CSF2 CXCL6 CXCL8 ICAM1 IL17A

GO Terms for Mastitis

Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CCL5 CP CSF2 CSN2 CSN3
2 extracellular space GO:0005615 9.55 ALB CCL5 CP CSF2 CSN2 CSN3
3 specific granule lumen GO:0035580 9.33 HP LTF SLPI

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
2 cellular protein metabolic process GO:0044267 9.94 ALB CP IL6 LTF
3 defense response GO:0006952 9.91 CXCL6 CXCL8 HP NOD2
4 inflammatory response GO:0006954 9.91 CCL5 CXCL6 CXCL8 IL17A IL6 NOD2
5 immune response GO:0006955 9.86 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6
6 defense response to Gram-positive bacterium GO:0050830 9.85 IL6 LALBA LBP TLR2
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 ICAM1 IL6 LTF NOD2 TLR2
8 defense response to Gram-negative bacterium GO:0050829 9.83 IL6 LALBA LBP LTF
9 chemokine-mediated signaling pathway GO:0070098 9.82 CCL5 CXCL6 CXCL8
10 neutrophil chemotaxis GO:0030593 9.81 CCL5 CXCL6 CXCL8
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 CCL5 CSF2 IL6
12 cellular response to interleukin-1 GO:0071347 9.8 CCL5 CXCL8 ICAM1 IL17A
13 response to lipopolysaccharide GO:0032496 9.8 CXCL6 CXCL8 ICAM1 LBP SLPI TLR2
14 positive regulation of tumor necrosis factor production GO:0032760 9.79 LBP NOD2 TLR2
15 lactation GO:0007595 9.79 CSN2 CSN3 STAT5A
16 negative regulation of viral genome replication GO:0045071 9.77 CCL5 LTF SLPI
17 acute-phase response GO:0006953 9.77 HP IL6 LBP
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.75 CCL5 LBP TLR2
19 positive regulation of neutrophil chemotaxis GO:0090023 9.74 CXCL6 CXCL8 LBP
20 positive regulation of interleukin-8 production GO:0032757 9.73 LBP NOD2 TLR2
21 positive regulation of interleukin-6 production GO:0032755 9.73 IL6 LBP NOD2 TLR2
22 positive regulation of leukocyte chemotaxis GO:0002690 9.71 CXCL6 CXCL8 IL6
23 positive regulation of chemokine production GO:0032722 9.69 IL6 LBP TLR2
24 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 NOD2 TLR2
25 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 TLR2
26 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.66 CCL5 CXCL8
27 cellular response to lipoteichoic acid GO:0071223 9.66 LBP TLR2
28 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.65 LBP LTF
29 neutrophil mediated immunity GO:0002446 9.65 CXCL6 IL6
30 neutrophil activation GO:0042119 9.65 CCL5 CXCL6 CXCL8
31 negative regulation of macrophage apoptotic process GO:2000110 9.63 CCL5 NOD2
32 cellular response to lipopolysaccharide GO:0071222 9.63 CSF2 CXCL6 CXCL8 ICAM1 IL6 LBP
33 positive regulation of interleukin-23 production GO:0032747 9.62 CSF2 IL17A
34 cytokine secretion involved in immune response GO:0002374 9.58 NOD2 TLR2
35 defense response to bacterium GO:0042742 9.5 CXCL6 HP LALBA LBP LTF NOD2
36 cytokine-mediated signaling pathway GO:0019221 9.23 CCL5 CSF2 CXCL8 ICAM1 IL17A IL6

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL5 CXCL6 CXCL8
2 CXCR chemokine receptor binding GO:0045236 9.32 CXCL6 CXCL8
3 lipopeptide binding GO:0071723 9.26 LBP TLR2
4 lipopolysaccharide binding GO:0001530 9.13 LBP LTF TLR2
5 cytokine activity GO:0005125 9.1 CCL5 CSF2 CXCL6 CXCL8 IL17A IL6

Sources for Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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