MCID: MST005
MIFTS: 53

Mastitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Mastitis

MalaCards integrated aliases for Mastitis:

Name: Mastitis 12 54 43 15 17 71
Inflammation of Non-Human Mammary Gland 71
Inflammatory Disorder of Breast 71
Inflammatory Disease of Breast 12
Inflammatory Breast Disease 12
Breast Inflammation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10690
MeSH 43 D008413
NCIt 49 C53662
SNOMED-CT 67 45198002
ICD10 32 N61
UMLS 71 C0024894 C3495439 C3668816

Summaries for Mastitis

Disease Ontology : 12 A breast disease characterized by painful infection of the breast tissue.

MalaCards based summary : Mastitis, also known as inflammation of non-human mammary gland, is related to toxic shock syndrome and breast abscess, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hydrocortisone acetate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and neutrophil, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Wikipedia : 74 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...

Related Diseases for Mastitis

Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 528)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 33.2 TLR2 LBP IL6 CXCL8
2 breast abscess 33.1 OXT MUC1
3 brucellosis 31.2 IL6 IL17A CXCL8
4 bacterial infectious disease 31.1 TLR2 NOD2 LTF LBP IL6 IL17A
5 endometritis 31.1 TLR2 OXT IL6 CXCL8
6 leptospirosis 30.9 TLR2 IL6 CXCL8
7 exanthem 30.9 IL6 CXCL8 ALB
8 pulmonary tuberculosis 30.9 TLR2 IL6 IL17A ALB
9 oral candidiasis 30.9 SLPI LTF IL17A CXCL8
10 gastroenteritis 30.8 IL6 CXCL8 CP ALB
11 necrotizing fasciitis 30.8 IL6 CXCL8 ALB
12 chlamydia 30.8 TLR2 IL6 IL17A CXCL8
13 candidiasis 30.7 TLR2 LTF IL6 IL17A CXCL8
14 endocarditis 30.7 TLR2 LBP IL6 IL17A CXCL8 ALB
15 proteasome-associated autoinflammatory syndrome 1 30.7 TLR2 IL6 IL17A CXCL8 CCL5 ALB
16 infective endocarditis 30.7 TLR2 LBP IL6 IL17A
17 haemophilus influenzae 30.7 TLR2 LTF CXCL8
18 aspergillosis 30.7 TLR2 NOD2 IL6 CXCL8 CCL5
19 mycobacterium kansasii 30.6 TLR2 CXCL8
20 pasteurellosis 30.6 SLPI CXCL8 ALB
21 reactive arthritis 30.6 TLR2 LTF LBP IL6 IL17A CXCL8
22 mycobacterium abscessus 30.6 TLR2 CXCL8
23 peritonitis 30.6 TLR2 LBP IL6 CXCL8 CCL5 ALB
24 relapsing polychondritis 30.5 IL6 IL17A CXCL8
25 echinococcosis 30.5 TLR2 IL6 IL17A
26 skin disease 30.5 TLR2 IL6 IL17A CXCL8 ALB
27 vaginal discharge 30.5 SLPI OXT IL6 CXCL8
28 meningoencephalitis 30.5 IL6 CCL5 ALB
29 endophthalmitis 30.5 TLR2 IL6 CXCL8 ALB
30 dermatitis 30.5 TLR2 NOD2 IL6 IL17A CXCL8 CCL5
31 alpha-1-antitrypsin deficiency 30.5 SLPI CXCL8 ALB
32 acute cystitis 30.5 TLR2 IL6 CXCL8 ALB
33 systemic lupus erythematosus 30.4 TLR2 LTF IL6 IL17A CXCL8 CP
34 sclerosing cholangitis 30.4 NOD2 IL6 CXCL8 ALB
35 salmonellosis 30.4 TLR2 IL6 CP ALB
36 allergic asthma 30.4 TLR2 IL17A CXCL8 CCL5
37 uveitis 30.4 NOD2 IL6 IL17A CXCL8
38 allergic hypersensitivity disease 30.4 TLR2 LALBA IL17A CXCL8 CSN3 CCL5
39 arthritis 30.3 TLR2 NOD2 IL6 IL17A CXCL8 CCL5
40 parasitic protozoa infectious disease 30.3 TLR2 IL6 IL17A CXCL8 ALB
41 bone inflammation disease 30.3 TLR2 IL6 IL17A CXCL8 ALB
42 keratoconjunctivitis 30.3 IL6 IL17A CXCL8 CCL5 ALB
43 osteomyelitis 30.3 TLR2 NOD2 IL6 CXCL8 CCL5
44 rhinitis 30.3 IL6 IL17A CXCL8 CCL5 ALB
45 cholangitis 30.3 NOD2 IL6 IL17A CXCL8 ALB
46 meningitis 30.2 TLR2 LBP IL6 IL17A CXCL8 CCL5
47 diabetes mellitus, insulin-dependent 30.2 TLR2 IL6 IL17A CSN2 ALB
48 bacterial pneumonia 30.2 TLR2 SLPI IL6 IL17A CXCL8 ALB
49 leprosy 3 30.1 TLR2 NOD2 IL6 IL17A CXCL8 ALB
50 crohn's disease 30.1 TLR2 NOD2 IL6 IL17A CXCL8 ALB

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis

Symptoms & Phenotypes for Mastitis

UMLS symptoms related to Mastitis:


signs and symptoms in breast

MGI Mouse Phenotypes related to Mastitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 ALB CSN2 CSN3 IL17A IL6 LALBA
2 hematopoietic system MP:0005397 9.7 CCL5 CP CXCL6 IL17A IL6 LBP
3 immune system MP:0005387 9.4 ALB CCL5 CP CXCL6 IL17A IL6

Drugs & Therapeutics for Mastitis

Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Hydrocortisone hemisuccinate Phase 4
5 Respiratory System Agents Phase 4
6 Hydrocortisone-17-butyrate Phase 4
7 Anti-Asthmatic Agents Phase 4
8 Hydrocortisone 17-butyrate 21-propionate Phase 4
9 Hormone Antagonists Phase 4
10 Betamethasone benzoate Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Dermatologic Agents Phase 4
13 Betamethasone Valerate Phase 4 2152-44-5
14 Betamethasone sodium phosphate Phase 4
15 glucocorticoids Phase 4
16 Hormones Phase 4
17 Betamethasone-17,21-dipropionate Phase 4
18
Loperamide Approved Phase 3 53179-11-6 3955
19
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
20
Clavulanate Approved, Vet_approved Phase 2, Phase 3 58001-44-8 5280980
21
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
22
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
23
Cefdinir Approved Phase 2, Phase 3 91832-40-5 6915944
24
Azithromycin Approved Phase 3 83905-01-5 55185 447043
25 Antidiarrheals Phase 3
26 Gastrointestinal Agents Phase 3
27 Antisecretory factor Phase 3
28 beta-Lactams Phase 2, Phase 3
29 Lactams Phase 2, Phase 3
30 beta-Lactamase Inhibitors Phase 2, Phase 3
31 Anti-Bacterial Agents Phase 2, Phase 3
32 Antibiotics, Antitubercular Phase 2, Phase 3
33 Anti-Infective Agents Phase 2, Phase 3
34 Antitubercular Agents Phase 2, Phase 3
35 Cephalosporins Phase 2, Phase 3
36
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
37
Tamoxifen Approved Phase 2 10540-29-1 2733526
38
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
39
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
40
Iodine Approved, Investigational Phase 2 7553-56-2 807
41
Tocopherol Approved, Investigational Phase 2 1406-66-2, 54-28-4 14986
42
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
43
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
44
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
45 Tocotrienol Investigational Phase 2 6829-55-6
46 Vaccines Phase 2
47 Immunologic Factors Phase 2
48 Estrogens Phase 2
49 Selective Estrogen Receptor Modulators Phase 2
50 BB 1101 Phase 2

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
2 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
3 Antisecretory Factor (AF) Effects on Intraocular-pressure: a Placebo-controlled Randomised Study Unknown status NCT02731118 Phase 3
4 Phase 2/3 Evaluation of Three Lactobacilli Strains Isolated From Human Milk for the Treatment of Infectious Mastitis During the Lactation Period Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
5 Partnership on Nutrition and HIV/AIDS Research in Tanzania: Exploratory Research Study on Selenium and HIV Infection Completed NCT00197561 Phase 3
6 The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis With Three Groups in Randomized Controlled Trial. Recruiting NCT03756324 Phase 2, Phase 3 CHPM (Chinese Herbal Patent Medicine );Antibiotics Cefdinir Capsules;Antibiotics Cefdinir Capsules
7 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death: a Phase III Double-blind Randomized Clinical Trial Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
8 Oral Administration of a Probiotic Strain to Pregnant Women: Effects on the Prevention of Lactational Mastitis and on the Eradication of GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
9 A Randomized, Double-Blind Trial, Comparing the Safety in Mothers and Their Infants and Immunogenicity in Mothers of Live Attenuated Influenza Vaccine (LAIV) to Inactivated Trivalent Influenza Vaccine (TIV) When Administered to Breast Feeding Women Completed NCT01181323 Phase 2
10 Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Completed NCT03715413 Phase 2 Tamoxifen
11 The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants: a Randomized, Double-blind, Placebo Controlled Study Recruiting NCT03310853 Phase 2
12 Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality. Active, not recruiting NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
13 Evaluation of Antisecretory Factor in Treatment of Severe Traumatic Brain Injury With Multimodal Monitoring Not yet recruiting NCT04117672 Phase 2
14 Antisecretory Factor, Administered as an Enriched Egg Powder, Salovum®, as Supplementary Therapy for Primary Glioblastoma During Concomitant Radio-chemotherapy. Not yet recruiting NCT04116138 Phase 1, Phase 2
15 A Phase II Study of the Use of Pentoxifylline and a-Tocopherol in the Treatment of Chronic Breast Pain Associated With Breast Radiotherapy Terminated NCT00188669 Phase 2 pentoxifylline;alpha-Tocopherol
16 Acupuncture for Breast Engorgement During Lactation: a Pilot Study. Unknown status NCT03230760
17 Early Screening of Breast Cancer Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
18 Early Detection of Breast Disease Using Medical Radiometer - RTM - 01 - RES Unknown status NCT02286583
19 Nutritional Intervention Study, Randomized, Double-blind, Parallel Group to Evaluate the Effect of Lactobacillus Fermentum CECT5716 Consumption on the Incidence of Mastitis Completed NCT02203877
20 A RCT in Sweden of Acupuncture and Care Interventions for the Relief of Inflammatory Symptoms of the Breast During Lactation Completed NCT00405158 Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
21 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis: A Large Prospective Study Completed NCT00620984
22 Oral Administration of a Probiotic to Lactating Women: Microbiological, Immunological, Transcriptomics and Metabolomics Effects Completed NCT01124448
23 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
24 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
25 Indian Postpartum Care: A-randomised Trial to Improve Maternal Health Six Weeks After Birth Completed NCT03715218
26 Study of Intervention Nutritional, Multicenter, Randomized, Blind, Parallel Group to Evaluate the Efficacy of Lactobacillus Fermentum CECT5716 to Reduce the Load Bacterial in Potential Pathogens in Milk of Mothers With Breast Pain Completed NCT02093338
27 Effectiveness of a Nursing Education Intervention on Duration of Breastfeeding and on Post-natal Breast Complications in Primiparous Women: a Randomized Controlled Trial Completed NCT02106026
28 Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty: A New Paradigm for Tackling Infant Stunting Completed NCT02755012
29 New Protocol for Identification of Serious Bacterial Infection in Febrile Newborn Completed NCT03183531
30 Development and Optimization of a GBS Micro Total Analysis System (µTAS) Prototype for the Direct Detection of Group B Streptococci in Vaginal/Anal Specimens From Intrapartum Maternity Patients Completed NCT00322829
31 A 60-Day Clinical Study to Evaluate Nutrilite Ginko Biloba Cistanche Tablets in Relieving the Symptoms of Chronic Fatigue Syndromes Compared to Negative Control Completed NCT02807649
32 Effect of Quiet or Listening to Music While Breastfeeding on the Production and Lipid and Sodium Content of the Milk Completed NCT01893047
33 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Recruiting NCT03724903 Corticosteroid therapy
34 Multicenter, Randomized, Double-blind, Controlled Parallel Nutritional Intervention Study to Evaluate the Effect of Consumption During Pregnancy and the Lactation Period of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Recruiting NCT04032899
35 Re-setting the Breast Microbiome to Lower Inflammation and Risk of Cancer. Recruiting NCT03290651
36 Traditional and Complementary Medicine: a Cure for Idiopathic Granulomatous Mastitis? Active, not recruiting NCT04096300
37 FDG-PET Imaging in Complicated Diabetic Foot (Protocol Version Dated 3/01/2004) Active, not recruiting NCT00194298
38 Continuation of Breastfeeding After Management of Breast Abscesses by Ultrasound-guided Punctures Not yet recruiting NCT03730467
39 The Scope of Tongue-tie in Norway: Its Prevalence and Consequences for Child Health Not yet recruiting NCT04056936
40 Strategies to Increase Milk Consumption by Young Nepali Children Not yet recruiting NCT03886467

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

MalaCards organs/tissues related to Mastitis:

40
Breast, Testes, Neutrophil, Skin, Liver, T Cells, Colon

Publications for Mastitis

Articles related to Mastitis:

(show top 50) (show all 11992)
# Title Authors PMID Year
1
Crosstalk between coagulation and inflammation in mastitis and metritis in dairy cows. 54 61
19584041 2009
2
Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli intramammary infection. 54 61
16954396 2006
3
Biosensor assay for determination of haptoglobin in bovine milk. 54 61
16569277 2006
4
A new diagnostic indicator using concanavalin a low-affinity lactoferrin levels in mammary gland secretion in mastitic drying cows. 54 61
16462118 2006
5
Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. 54 61
15074326 2004
6
Indicators of inflammation in the diagnosis of mastitis. 54 61
14556695 2003
7
[Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions?]. 54 61
12161968 2002
8
Acute phase response in naturally occurring coliform mastitis. 54 61
11459016 2001
9
Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels. 54 61
11252382 2001
10
Acute phase proteins in serum and milk from dairy cows with clinical mastitis. 54 61
11202551 2001
11
Mastitis and transmission of human immunodeficiency virus through breast milk. 54 61
11131699 2000
12
Mastitis and immunological factors in breast milk of lactating women in Malawi. 54 61
10473515 1999
13
Factors contributing to variation in the proportion of casein in cows' milk true protein: a review of recent INRA experiments. 54 61
9718491 1998
14
Reduced lactational performance following intravenous endotoxin administration to dairy cows. 54 61
1744270 1991
15
Inhibition of Escherichia coli invasion into bovine mammary epithelial cells previously infected by Mycobacterium avium subsp. paratuberculosis. 61
31939335 2020
16
Nanoparticles for treatment of bovine Staphylococcus aureus mastitis. 61
32036717 2020
17
H2S mediates apoptosis in response to inflammation through PI3K/Akt/NFκB signaling pathway. 61
31872317 2020
18
1-Hydroxyanthraquinone exhibited antibacterial activity by regulating glutamine synthetase of Staphylococcus xylosus as a virulence factor. 61
31918211 2020
19
Review: Relationships between metabolism and neutrophil function in dairy cows in the peripartum period. 61
32024567 2020
20
Granulomatous mastitis due to coinfection with Histoplasma sp. and Paracoccidioides sp.: A case report. 61
31993319 2020
21
Role of Toll-like receptor 2 against Streptococcus uberis infection in primary mouse mammary epithelial cells. 61
31931293 2020
22
Differential somatic cell count as an additional indicator for intramammary infections in dairy cows. 61
31759594 2020
23
Noninferiority study evaluating the efficacy of a teat disinfectant containing copper and zinc for prevention of naturally occurring intramammary infections in an automatic milking system. 61
31864745 2020
24
Evaluation of a bovine cathelicidin ELISA for detecting mastitis in the dairy buffalo: Comparison with milk somatic cell count and bacteriological culture. 61
31783263 2020
25
Identification of candidate genes affecting chronic subclinical mastitis in Norwegian Red cattle: combining genome-wide association study, topologically associated domains and pathway enrichment analysis. 61
31808564 2020
26
Comparison of the population structure of Streptococcus uberis mastitis isolates from Austrian small-scale dairy farms and a Slovakian large-scale farm. 61
31837784 2020
27
Distribution of Lactococcus spp. in New York State dairy farms and the association of somatic cell count resolution and bacteriological cure in clinical mastitis samples. 61
31864733 2020
28
Short communication: Investigation of extra-intestinal pathogenic Escherichia coli virulence genes, bacterial motility, and multidrug resistance pattern of strains isolated from dairy cows with different severity scores of clinical mastitis. 61
32037173 2020
29
Invited review: Compost-bedded pack barns for dairy cows. 61
31837797 2020
30
Breast infections - Microbiology and treatment in an era of antibiotic resistance. 61
31076276 2020
31
Molecular epidemiology of Streptococcus uberis intramammary infections: Persistent and transient patterns of infection in a dairy herd. 61
32037160 2020
32
Genomic evaluation for wellness traits in US Jersey cattle. 61
31837791 2020
33
20-hydroxyeicosatetraenoic acid alters endothelial cell barrier integrity independent of oxidative stress and cell death. 61
32032703 2020
34
Dairy producers in the Southeast United States are concerned with cow care and welfare. 61
32019631 2020
35
Serum vitamin D concentrations at dry-off and close-up predict increased postpartum urine ketone concentrations in dairy cattle. 61
31759612 2020
36
Lymphocytic mastitis mimicking breast cancer in an elderly woman. 61
32034839 2020
37
Differentiation between idiopathic granulomatous mastitis and invasive breast carcinoma, both presenting with non-mass enhancement without rim-enhanced masses: The value of whole-lesion histogram and texture analysis using apparent diffusion coefficient. 61
31864142 2020
38
An in silico evaluation of non-synonymous single nucleotide polymorphisms of mastitis resistance genes in cattle. 61
30614365 2020
39
Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells. 61
32037181 2020
40
Association between teat-end hyperkeratosis and mastitis in dairy cows: A systematic review. 61
31759610 2020
41
Combined effect of mastitis and parity on pregnancy loss in lactating Holstein cows. 61
31837631 2020
42
Idiopathic granulomatous mastitis in the male population: A clinical analysis of 13 reported cases. 61
32034843 2020
43
LRRC75A antisense lncRNA1 knockout attenuates inflammatory responses of bovine mammary epithelial cells. 61
31929753 2020
44
Polymorphism association and expression analysis of alpha-lactalbumin (LALBA) gene during lactation in Nili Ravi buffalo. 61
31352551 2020
45
Genome-wide analysis of mRNAs and lncRNAs in Mycoplasma bovis infected and non-infected bovine mammary gland tissues. 61
31972225 2020
46
Extract of Mangifera indica L. leaves may reduce biofilms of Staphylococcus spp. in stainless steel and teatcup rubbers. 61
31370696 2020
47
Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-κB and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier. 61
31711938 2020
48
Short communication: Bovine mastitis caused by a multidrug-resistant, mcr-1-positive (colistin-resistant), extended-spectrum β-lactamase-producing Escherichia coli clone on a Greek dairy farm. 61
31733863 2020
49
Genome-wide methylation and transcriptome of blood neutrophils reveal the roles of DNA methylation in affecting transcription of protein-coding genes and miRNAs in E. coli-infected mastitis cows. 61
32000686 2020
50
Devastating gynecological infections in women with STAT3 deficiency. 61
31916572 2020

Variations for Mastitis

Expression for Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for Mastitis

Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TLR2 STAT5A SLPI NOD2 MUC1 LTF
2
Show member pathways
13.19 STAT5A NOD2 MUC1 LBP IL6 IL17A
3
Show member pathways
12.94 TLR2 STAT5A NOD2 LBP IL6 CXCL8
4
Show member pathways
12.72 TLR2 STAT5A IL6 CXCL8 CCL5
5
Show member pathways
12.45 TLR2 STAT5A NOD2 IL6 IL17A
6
Show member pathways
12.23 IL6 CXCL8 CXCL6 CCL5
7
Show member pathways
12.14 TLR2 IL6 IL17A CXCL8 CXCL6
8 12.13 NOD2 IL6 CXCL8 CCL5
9 12.12 TLR2 NOD2 LBP IL6
10
Show member pathways
12.1 TLR2 IL6 CXCL8 CP
11
Show member pathways
11.91 TLR2 STAT5A IL6 IL17A
12
Show member pathways
11.87 TLR2 MUC1 LBP IL6 CXCL8
13 11.78 NOD2 IL6 CXCL6 CCL5
14
Show member pathways
11.73 LBP IL6 A2M
15 11.69 LBP IL6 CXCL8
16 11.66 IL6 CXCL8 CXCL6
17 11.61 MUC1 LBP IL6 IL17A CXCL8
18 11.58 STAT5A IL6 CXCL8 CSN2
19 11.57 IL6 CXCL8 CCL5
20 11.52 TLR2 IL6 CXCL8
21 11.47 IL6 IL17A CCL5 A2M
22 11.42 TLR2 IL6 CXCL8
23 11.4 IL6 CXCL8 CCL5
24 11.37 STAT5A IL6 CXCL8
25
Show member pathways
11.32 LBP IL6 IL17A CXCL8 CXCL6
26 11.07 TLR2 IL6 IL17A CXCL8 CXCL6 CCL5

GO Terms for Mastitis

Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 SLPI OXT MUC1 LTF LPO LBP
2 extracellular space GO:0005615 9.55 SLPI OXT MUC1 LTF LPO LBP

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.93 LTF IL6 CP ALB
2 cell-cell signaling GO:0007267 9.92 LALBA IL17A CXCL6 CCL5
3 response to lipopolysaccharide GO:0032496 9.88 TLR2 SLPI LBP CXCL6
4 inflammatory response GO:0006954 9.88 TLR2 IL6 IL17A CXCL8 CXCL6 CCL5
5 defense response GO:0006952 9.86 STAT5A NOD2 CXCL8 CXCL6
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 TLR2 NOD2 LTF IL6
7 neutrophil chemotaxis GO:0030593 9.82 CXCL8 CXCL6 CCL5
8 cellular response to interleukin-1 GO:0071347 9.81 IL17A CXCL8 CCL5
9 chemokine-mediated signaling pathway GO:0070098 9.79 CXCL8 CXCL6 CCL5
10 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.78 LTF CXCL8 CXCL6
11 defense response to Gram-positive bacterium GO:0050830 9.78 TLR2 LBP LALBA IL6
12 positive regulation of tumor necrosis factor production GO:0032760 9.77 TLR2 NOD2 LBP
13 cellular response to lipopolysaccharide GO:0071222 9.77 NOD2 LBP IL6 CXCL8 CXCL6
14 defense response to Gram-negative bacterium GO:0050829 9.76 LTF LBP LALBA IL6
15 lactation GO:0007595 9.74 STAT5A CSN3 CSN2
16 negative regulation of viral genome replication GO:0045071 9.71 SLPI LTF CCL5
17 immune response GO:0006955 9.7 TLR2 SLPI IL6 IL17A CXCL8 CXCL6
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TLR2 LBP CCL5
19 positive regulation of interleukin-8 production GO:0032757 9.67 TLR2 NOD2 LBP
20 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.65 CXCL8 CCL5
21 response to molecule of bacterial origin GO:0002237 9.65 TLR2 CXCL8
22 cellular response to lipoteichoic acid GO:0071223 9.63 TLR2 LBP
23 positive regulation of interleukin-6 production GO:0032755 9.62 TLR2 NOD2 LBP IL6
24 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.61 LTF LBP
25 positive regulation of chemokine production GO:0032722 9.61 TLR2 LBP IL6
26 negative regulation of macrophage apoptotic process GO:2000110 9.6 NOD2 CCL5
27 negative regulation of cysteine-type endopeptidase activity GO:2000117 9.58 LTF CSN2
28 cytokine secretion involved in immune response GO:0002374 9.52 TLR2 NOD2
29 cytokine-mediated signaling pathway GO:0019221 9.5 STAT5A MUC1 LBP IL6 IL17A CXCL8
30 neutrophil activation GO:0042119 9.43 CXCL8 CXCL6 CCL5
31 defense response to bacterium GO:0042742 9.17 SLPI NOD2 LTF LPO LBP LALBA

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CXCL8 CXCL6 CCL5
2 lipopeptide binding GO:0071723 9.26 TLR2 LBP
3 lipopolysaccharide binding GO:0001530 9.13 TLR2 LTF LBP
4 cytokine activity GO:0005125 9.02 IL6 IL17A CXCL8 CXCL6 CCL5

Sources for Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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