MCID: MST005
MIFTS: 55

Mastitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Mastitis

MalaCards integrated aliases for Mastitis:

Name: Mastitis 12 55 44 15 17 72
Inflammation of Non-Human Mammary Gland 72
Inflammatory Disorder of Breast 72
Inflammatory Disease of Breast 12
Inflammatory Breast Disease 12
Breast Inflammation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10690
MeSH 44 D008413
NCIt 50 C53662
SNOMED-CT 68 45198002
ICD10 33 N61
UMLS 72 C0024894 C3495439 C3668816

Summaries for Mastitis

Disease Ontology : 12 A breast disease characterized by painful infection of the breast tissue.

MalaCards based summary : Mastitis, also known as inflammation of non-human mammary gland, is related to toxic shock syndrome and leptospirosis, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and neutrophil, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...

Related Diseases for Mastitis

Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 402)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 33.1 TLR2 IL6 CXCL8
2 leptospirosis 30.8 TLR2 IL6 CXCL8
3 chlamydia 30.7 TLR2 IL6 CXCL8
4 gastroenteritis 30.7 IL6 CXCL8 ALB
5 infective endocarditis 30.6 TLR2 LBP IL6
6 haemophilus influenzae 30.6 TLR2 LTF CXCL8
7 mycobacterium kansasii 30.5 TLR2 CXCL8
8 pneumonia 30.5 TLR2 IL6 CXCL8 CCL5
9 keratoconjunctivitis sicca 30.5 LTF IL6 ALB
10 acute cystitis 30.4 IL6 CXCL8 ALB
11 meningitis 30.4 TLR2 IL6 CXCL8 ALB
12 endocarditis 30.4 TLR2 LBP IL6 CXCL8 ALB
13 bacterial pneumonia 30.3 IL6 IL17A CXCL8
14 meningoencephalitis 30.3 IL6 CCL5 ALB
15 echinococcosis 30.3 TLR2 IL6 IL17A
16 endometritis 30.3 OXT IL6 HP
17 bone inflammation disease 30.3 IL6 IL17A CXCL8
18 peritonitis 30.2 TLR2 LBP IL6 CXCL8 ALB
19 parasitic protozoa infectious disease 30.0 TLR2 IL6 HP
20 bacterial infectious disease 29.9 TLR2 NOD2 LBP IL6 IL17A CXCL8
21 proteasome-associated autoinflammatory syndrome 1 29.9 TLR2 IL6 IL17A CXCL8 CCL5 ALB
22 interstitial lung disease 29.9 IL6 CXCL8 CCL5
23 arthritis 29.9 NOD2 IL6 IL17A CXCL8 CSF2
24 cholangitis 29.8 IL6 HP ALB
25 inflammatory bowel disease 29.7 TLR2 NOD2 IL6 IL17A CXCL8
26 bilirubin metabolic disorder 29.7 OXT HP ALB
27 lung disease 28.9 TLR2 SLPI IL6 IL17A CXCL8 CSF2
28 rheumatoid arthritis 28.6 TLR2 IL6 IL17A CXCL8 CXCL6 CSF2
29 granulomatous mastitis 12.7
30 granulomatous lobular mastitis 12.7
31 neonatal infective mastitis 12.4
32 eosinophilic mastitis 12.3
33 breast abscess 11.6
34 inflammatory breast carcinoma 11.6
35 diabetic mastopathy 11.5
36 breast cancer 10.8
37 mycobacterium chelonae 10.7 TLR2 CXCL8
38 breast disease 10.7
39 mycobacterium marinum 10.7 TLR2 CXCL8
40 scorpion envenomation 10.7 IL6 CCL5
41 recurrent corneal erosion 10.6 IL6 CXCL8
42 bagassosis 10.6 IL6 CXCL8
43 pouchitis 10.6 NOD2 LTF CXCL8
44 middle ear disease 10.6 TLR2 IL6 CXCL8
45 bacterial vaginosis 10.6 TLR2 IL6 CXCL8
46 aggressive periodontitis 10.5 LTF IL6 CXCL8
47 meningitis and encephalitis 10.5 CP ALB
48 acute pyelonephritis 10.5 IL6 CXCL8 ALB
49 pyelonephritis 10.5 IL6 CXCL8 ALB
50 lupus erythematosus 10.5

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis

Symptoms & Phenotypes for Mastitis

UMLS symptoms related to Mastitis:


signs and symptoms in breast

GenomeRNAi Phenotypes related to Mastitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.32 LBP
2 Decreased viability GR00381-A-1 9.32 CSN3 LBP LTF
3 Decreased viability GR00381-A-3 9.32 CSN3 LBP LTF
4 Decreased viability GR00402-S-2 9.32 CSN3 LBP LTF

MGI Mouse Phenotypes related to Mastitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 CCL5 CP CSF2 CXCL6 HP IL17A
2 homeostasis/metabolism MP:0005376 10.17 ALB CP CSF2 CXCL6 HP IL17A
3 endocrine/exocrine gland MP:0005379 10.1 ALB CSF2 CSN2 CSN3 IL17A IL6
4 immune system MP:0005387 10.07 CCL5 CP CSF2 CXCL6 HP IL17A
5 adipose tissue MP:0005375 9.91 CP CSF2 IL6 OXT STAT5A TLR2
6 integument MP:0010771 9.76 CSF2 CSN2 CSN3 IL6 LALBA OXT
7 liver/biliary system MP:0005370 9.56 ALB CP HP IL6 LBP LTF
8 renal/urinary system MP:0005367 9.17 ALB CSF2 HP IL17A IL6 OXT

Drugs & Therapeutics for Mastitis

Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Dermatologic Agents Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Hydrocortisone 17-butyrate 21-propionate Phase 4
7 Hydrocortisone hemisuccinate Phase 4
8 Hydrocortisone-17-butyrate Phase 4
9 Respiratory System Agents Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Anti-Asthmatic Agents Phase 4
13 Hormone Antagonists Phase 4
14 Betamethasone-17,21-dipropionate Phase 4
15 Betamethasone Valerate Phase 4 2152-44-5
16 Betamethasone sodium phosphate Phase 4
17 Betamethasone benzoate Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19
Loperamide Approved Phase 3 53179-11-6 3955
20
Clavulanate Approved, Vet_approved Phase 2, Phase 3 58001-44-8 5280980
21
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
22
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
23
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
24
Cefdinir Approved Phase 2, Phase 3 91832-40-5 6915944
25
Azithromycin Approved Phase 3 83905-01-5 447043 55185
26 Gastrointestinal Agents Phase 3
27 Antisecretory factor Phase 3
28 Antidiarrheals Phase 3
29 Lactams Phase 2, Phase 3
30 beta-Lactamase Inhibitors Phase 2, Phase 3
31 beta-Lactams Phase 2, Phase 3
32 Anti-Bacterial Agents Phase 2, Phase 3
33 Antibiotics, Antitubercular Phase 2, Phase 3
34 Anti-Infective Agents Phase 2, Phase 3
35 Antitubercular Agents Phase 2, Phase 3
36 Cephalosporins Phase 2, Phase 3
37
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
38
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
39
Tamoxifen Approved Phase 2 10540-29-1 2733526
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
41
Iodine Approved, Investigational Phase 2 7553-56-2 807
42
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
43
Tocopherol Approved, Investigational Phase 2 1406-66-2, 54-28-4 14986
44
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
45
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
46 Tocotrienol Investigational Phase 2 6829-55-6
47 Analgesics Phase 2
48 Peripheral Nervous System Agents Phase 2
49 Vaccines Phase 2
50 Immunologic Factors Phase 2

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
2 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
3 Antisecretory Factor (AF) Effects on Intraocular-pressure: a Placebo-controlled Randomised Study Unknown status NCT02731118 Phase 3
4 Phase 2/3 Evaluation of Three Lactobacilli Strains Isolated From Human Milk for the Treatment of Infectious Mastitis During the Lactation Period Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
5 Partnership on Nutrition and HIV/AIDS Research in Tanzania: Exploratory Research Study on Selenium and HIV Infection Completed NCT00197561 Phase 3
6 The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis With Three Groups in Randomized Controlled Trial. Recruiting NCT03756324 Phase 2, Phase 3 CHPM (Chinese Herbal Patent Medicine );Antibiotics Cefdinir Capsules;Antibiotics Cefdinir Capsules
7 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death: a Phase III Double-blind Randomized Clinical Trial Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
8 Oral Administration of a Probiotic Strain to Pregnant Women: Effects on the Prevention of Lactational Mastitis and on the Eradication of GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
9 A Randomized, Double-Blind Trial, Comparing the Safety in Mothers and Their Infants and Immunogenicity in Mothers of Live Attenuated Influenza Vaccine (LAIV) to Inactivated Trivalent Influenza Vaccine (TIV) When Administered to Breast Feeding Women Completed NCT01181323 Phase 2
10 Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Completed NCT03715413 Phase 2 Tamoxifen
11 The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants: a Randomized, Double-blind, Placebo Controlled Study Recruiting NCT03310853 Phase 2
12 Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality. Active, not recruiting NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
13 A Phase II Study of the Use of Pentoxifylline and a-Tocopherol in the Treatment of Chronic Breast Pain Associated With Breast Radiotherapy Terminated NCT00188669 Phase 2 pentoxifylline;alpha-Tocopherol
14 Acupuncture for Breast Engorgement During Lactation: a Pilot Study. Unknown status NCT03230760
15 Early Screening of Breast Cancer Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
16 Early Detection of Breast Disease Using Medical Radiometer - RTM - 01 - RES Unknown status NCT02286583
17 Nutritional Intervention Study, Randomized, Double-blind, Parallel Group to Evaluate the Effect of Lactobacillus Fermentum CECT5716 Consumption on the Incidence of Mastitis Completed NCT02203877
18 A RCT in Sweden of Acupuncture and Care Interventions for the Relief of Inflammatory Symptoms of the Breast During Lactation Completed NCT00405158 Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
19 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis: A Large Prospective Study Completed NCT00620984
20 Oral Administration of a Probiotic to Lactating Women: Microbiological, Immunological, Transcriptomics and Metabolomics Effects Completed NCT01124448
21 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
22 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
23 Indian Postpartum Care: A-randomised Trial to Improve Maternal Health Six Weeks After Birth Completed NCT03715218
24 Study of Intervention Nutritional, Multicenter, Randomized, Blind, Parallel Group to Evaluate the Efficacy of Lactobacillus Fermentum CECT5716 to Reduce the Load Bacterial in Potential Pathogens in Milk of Mothers With Breast Pain Completed NCT02093338
25 Effectiveness of a Nursing Education Intervention on Duration of Breastfeeding and on Post-natal Breast Complications in Primiparous Women: a Randomized Controlled Trial Completed NCT02106026
26 The Prevalence of Yeast and Bacteria in Women With Painful Breastfeeding and the Diagnostic Value of Signs and Symptoms Completed NCT01631461
27 Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty: A New Paradigm for Tackling Infant Stunting Completed NCT02755012
28 New Protocol for Identification of Serious Bacterial Infection in Febrile Newborn Completed NCT03183531
29 Development and Optimization of a GBS Micro Total Analysis System (µTAS) Prototype for the Direct Detection of Group B Streptococci in Vaginal/Anal Specimens From Intrapartum Maternity Patients Completed NCT00322829
30 A 60-Day Clinical Study to Evaluate Nutrilite Ginko Biloba Cistanche Tablets in Relieving the Symptoms of Chronic Fatigue Syndromes Compared to Negative Control Completed NCT02807649
31 Effect of Quiet or Listening to Music While Breastfeeding on the Production and Lipid and Sodium Content of the Milk Completed NCT01893047
32 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Recruiting NCT03724903 Corticosteroid therapy
33 Multicenter, Randomized, Double-blind, Controlled Parallel Nutritional Intervention Study to Evaluate the Effect of Consumption During Pregnancy and the Lactation Period of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Recruiting NCT04032899
34 Re-setting the Breast Microbiome to Lower Inflammation and Risk of Cancer. Recruiting NCT03290651
35 FDG-PET Imaging in Complicated Diabetic Foot (Protocol Version Dated 3/01/2004) Active, not recruiting NCT00194298
36 Continuation of Breastfeeding After Management of Breast Abscesses by Ultrasound-guided Punctures Not yet recruiting NCT03730467
37 The Scope of Tongue-tie in Norway: Its Prevalence and Consequences for Child Health Not yet recruiting NCT04056936
38 Strategies to Increase Milk Consumption by Young Nepali Children Not yet recruiting NCT03886467

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

MalaCards organs/tissues related to Mastitis:

41
Breast, Testes, Neutrophil, Skin, Colon, Liver, Endothelial

Publications for Mastitis

Articles related to Mastitis:

(show top 50) (show all 11705)
# Title Authors PMID Year
1
Crosstalk between coagulation and inflammation in mastitis and metritis in dairy cows. 9 38
19584041 2009
2
Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli intramammary infection. 9 38
16954396 2006
3
Biosensor assay for determination of haptoglobin in bovine milk. 9 38
16569277 2006
4
A new diagnostic indicator using concanavalin a low-affinity lactoferrin levels in mammary gland secretion in mastitic drying cows. 9 38
16462118 2006
5
Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. 9 38
15074326 2004
6
Indicators of inflammation in the diagnosis of mastitis. 9 38
14556695 2003
7
[Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions?]. 9 38
12161968 2002
8
Acute phase response in naturally occurring coliform mastitis. 9 38
11459016 2001
9
Acute phase proteins in serum and milk from dairy cows with clinical mastitis. 9 38
11202551 2001
10
Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels. 9 38
11252382 2001
11
Mastitis and transmission of human immunodeficiency virus through breast milk. 9 38
11131699 2000
12
Mastitis and immunological factors in breast milk of lactating women in Malawi. 9 38
10473515 1999
13
Factors contributing to variation in the proportion of casein in cows' milk true protein: a review of recent INRA experiments. 9 38
9718491 1998
14
Reduced lactational performance following intravenous endotoxin administration to dairy cows. 9 38
1744270 1991
15
Immunodetection of Streptococcus uberis pathogen in raw milk. 38
31421723 2019
16
Ultrasound-guided interfascial hydrodissection for severe pain in mastitis. 38
30852325 2019
17
Effect of bovine leukemia virus on bovine mammary epithelial cells. 38
31381943 2019
18
[Idiopathic granulomatous mastitis associated with erythema nodosum]. 38
31151772 2019
19
Staphylococcus aureus induces autophagy in bovine mammary epithelial cells and the formation of autophagosomes facilitates intracellular replication of Staph. aureus. 38
31255277 2019
20
Short communication: Herd-level variables associated with overmilking in Michigan dairy herds. 38
31279548 2019
21
Pathological and microbiological characterization of mastitis in dairy cows. 38
31073889 2019
22
Quantifying the effects of mastitis on the reproductive performance of dairy cows: A meta-analysis. 38
31229281 2019
23
Efficacy of a Ruminal Bacteriocin Against Pure and Mixed Cultures of Bovine Mastitis Pathogens. 38
31388207 2019
24
Short communication: Mycolicibacterium smegmatis, basonym Mycobacterium smegmatis, causing pyogranulomatous mastitis and its cross-reactivity in bovine (para)tuberculosis testing. 38
31301842 2019
25
Selenium Attenuates Staphylococcus aureus Mastitis in Mice by Inhibiting the Activation of the NALP3 Inflammasome and NF-κB/MAPK Pathway. 38
30523572 2019
26
Aetiology and prevalence of subclinical mastitis in dairy herds in peri-urban areas of Kigali in Rwanda. 38
31030333 2019
27
Corrigendum to "A survey on the incidence of Prototheca mastitis in dairy herds in Lublin province, Poland" (J. Dairy Sci. 102:619-628). 38
31402009 2019
28
Comparison of quantitative PCR and MALDI-TOF mass spectrometry assays for identification of bacteria in milk samples from cows with subclinical mastitis. 38
31216600 2019
29
Systemic vasculitis involving the breast: a case report and literature review. 38
30874872 2019
30
Re-evaluating if observation continues to be the best management of idiopathic granulomatous mastitis. 38
31400951 2019
31
Rosai-Dorfman Disease of the Breast With Variable IgG4+ Plasma Cells: A Diagnostic Mimicker of Other Malignant and Reactive Entities. 38
31436555 2019
32
Staphylococcus aureus-specific IgA antibody in milk suppresses the multiplication of S. aureus in infected bovine udder. 38
31399125 2019
33
Phenotypic antimicrobial susceptibility of environmental bacteria from mastitic milk of pastured dairy cows of S. Miguel (Azores). 38
31376059 2019
34
Immunological responses and evaluation of the protection in dairy cows vaccinated with staphylococcal surface proteins. 38
31378218 2019
35
The distribution of clones of Streptococcus agalactiae (group B streptococci) among herdspersons and dairy cows demonstrates lack of host specificity for some lineages. 38
31282381 2019
36
Production of lipid mediators in mastitic milk of cow. 38
31148331 2019
37
Determining and unravelling origins of reduced photoinactivation efficacy of bacteria in milk. 38
31326843 2019
38
Risk Factors for the Occurrence of Methicillin-Resistant Staphylococcus aureus in Dairy Herds: An Update. 38
31433237 2019
39
Differential phenotype of immune cells in blood and milk following pegylated granulocyte colony-stimulating factor therapy during a chronic Staphylococcus aureus infection in lactating Holsteins. 38
31400902 2019
40
Short communication: Intra- and inter-individual milk microbiota variability in healthy and infected water buffalo udder quarters. 38
31178197 2019
41
Silviavirus phage ɸMR003 displays a broad host range against methicillin-resistant Staphylococcus aureus of human origin. 38
31388727 2019
42
Extract of Mangifera indica L. leaves may reduce biofilms of Staphylococcus spp. in stainless steel and teatcup rubbers. 38
31370696 2019
43
UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells. 38
31078114 2019
44
Emergence of Fungal-Like Organisms: Prototheca. 38
31401758 2019
45
Gold Nanoparticle Size-Dependent Enhanced Chemiluminescence for Ultra-Sensitive Haptoglobin Biomarker Detection. 38
31416293 2019
46
Exogenous hydrogen sulfide prevents lipopolysaccharide-induced inflammation by blocking the TLR4/NF-κB pathway in MAC-T cells. 38
31153885 2019
47
Bayesian estimation of qPCR and bacterial culture accuracy for detection of bovine coagulase-negative staphylococci from milk and teat apex at different test cut-off points. 38
31077513 2019
48
Effectiveness of breast massage for the treatment of women with breastfeeding problems: a systematic review. 38
31135656 2019
49
A Meta-Analysis on the Impact of the Supplementation of Rumen-Protected Choline on the Metabolic Health and Performance of Dairy Cattle. 38
31426430 2019
50
Cohort-level disease prediction by extrapolation of individual-level predictions in transition dairy cattle. 38
31311636 2019

Variations for Mastitis

Expression for Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for Mastitis

Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TLR2 STAT5A SLPI NOD2 LTF LBP
2
Show member pathways
13.31 TLR2 STAT5A IL6 IL17A CXCL8 CXCL6
3
Show member pathways
13.24 STAT5A NOD2 LBP IL6 IL17A CXCL8
4
Show member pathways
13.04 TLR2 NOD2 LBP IL6 CXCL8 CCL5
5
Show member pathways
12.91 TLR2 STAT5A IL6 CXCL8 CSF2 CCL5
6
Show member pathways
12.5 TLR2 STAT5A NOD2 IL6 IL17A
7
Show member pathways
12.18 TLR2 IL6 IL17A CXCL8 CXCL6 CSF2
8 12.17 TLR2 NOD2 LBP IL6
9
Show member pathways
12.16 TLR2 IL6 CXCL8 CP
10
Show member pathways
12.12 TLR2 LBP IL6 CXCL8
11
Show member pathways
11.96 TLR2 STAT5A IL6 IL17A
12 11.87 LBP IL6 IL17A CXCL8
13 11.84 NOD2 IL6 CSF2 CCL5
14 11.83 STAT5A IL6 CXCL8
15 11.79 TLR2 IL6 CXCL8 CSF2
16
Show member pathways
11.76 LBP IL6 A2M
17 11.7 IL6 CXCL8 CXCL6
18 11.67 LBP IL6 CXCL8 CSF2
19
Show member pathways
11.61 IL6 CXCL8 CSF2
20 11.57 STAT5A IL6 CXCL8 CSN2 CSF2
21 11.55 TLR2 IL6 CXCL8
22 11.53 IL6 CXCL8 CSF2 CCL5
23 11.47 TLR2 IL6 CXCL8
24 11.45 STAT5A IL6 CSF2
25 11.43 STAT5A IL6 CXCL8
26 11.4 IL6 CXCL8 CSF2 CCL5
27 11.4 IL6 IL17A CSF2 CCL5 A2M
28
Show member pathways
11.4 LBP IL6 IL17A CXCL8 CXCL6 CSF2
29 11.14 TLR2 IL6 IL17A CXCL8 CXCL6 CSF2
30 11.03 IL6 IL17A CXCL8 CXCL6 CSF2 CCL5
31 10.92 IL6 IL17A CXCL8 CXCL6 CSF2 CCL5

GO Terms for Mastitis

Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 SLPI OXT LTF LBP LALBA IL6
2 extracellular space GO:0005615 9.55 SLPI OXT LTF LBP LALBA IL6
3 blood microparticle GO:0072562 9.46 HP CP ALB A2M
4 specific granule lumen GO:0035580 9.43 SLPI LTF HP

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.94 LALBA IL17A CXCL6 CCL5
2 cellular protein metabolic process GO:0044267 9.92 LTF IL6 CP ALB
3 response to lipopolysaccharide GO:0032496 9.9 TLR2 SLPI LBP CXCL6
4 inflammatory response GO:0006954 9.88 TLR2 IL6 IL17A CXCL8 CXCL6 CCL5
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 TLR2 NOD2 LTF IL6
6 defense response GO:0006952 9.86 NOD2 HP CXCL8 CXCL6
7 neutrophil chemotaxis GO:0030593 9.83 CXCL8 CXCL6 CCL5
8 cellular response to interleukin-1 GO:0071347 9.83 IL17A CXCL8 CCL5
9 chemokine-mediated signaling pathway GO:0070098 9.81 CXCL8 CXCL6 CCL5
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 IL6 CSF2 CCL5
11 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.79 LTF CXCL8 CXCL6
12 positive regulation of tumor necrosis factor production GO:0032760 9.78 TLR2 NOD2 LBP
13 defense response to Gram-positive bacterium GO:0050830 9.78 TLR2 LBP LALBA IL6
14 defense response to Gram-negative bacterium GO:0050829 9.76 LTF LBP LALBA IL6
15 immune response GO:0006955 9.76 TLR2 SLPI IL6 IL17A CXCL8 CXCL6
16 lactation GO:0007595 9.75 STAT5A CSN3 CSN2
17 cellular response to lipopolysaccharide GO:0071222 9.73 NOD2 LBP IL6 CXCL8 CXCL6 CSF2
18 negative regulation of viral genome replication GO:0045071 9.72 SLPI LTF CCL5
19 acute-phase response GO:0006953 9.71 LBP IL6 HP
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TLR2 LBP CCL5
21 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR2 NOD2
22 positive regulation of interleukin-8 production GO:0032757 9.67 TLR2 NOD2 LBP
23 positive regulation of interleukin-6 production GO:0032755 9.67 TLR2 NOD2 LBP IL6
24 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.66 CXCL8 CCL5
25 response to molecule of bacterial origin GO:0002237 9.66 TLR2 CXCL8
26 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.65 LTF LBP
27 cellular response to lipoteichoic acid GO:0071223 9.64 TLR2 LBP
28 negative regulation of macrophage apoptotic process GO:2000110 9.61 NOD2 CCL5
29 positive regulation of chemokine production GO:0032722 9.61 TLR2 LBP IL6
30 positive regulation of interleukin-23 production GO:0032747 9.59 IL17A CSF2
31 negative regulation of cysteine-type endopeptidase activity GO:2000117 9.58 LTF CSN2
32 cytokine secretion involved in immune response GO:0002374 9.51 TLR2 NOD2
33 neutrophil activation GO:0042119 9.5 CXCL8 CXCL6 CCL5
34 cytokine-mediated signaling pathway GO:0019221 9.5 STAT5A LBP IL6 IL17A CXCL8 CSF2
35 defense response to bacterium GO:0042742 9.17 SLPI NOD2 LTF LBP LALBA HP

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CXCL8 CXCL6 CCL5
2 lipopeptide binding GO:0071723 9.26 TLR2 LBP
3 lipopolysaccharide binding GO:0001530 9.13 TLR2 LTF LBP
4 cytokine activity GO:0005125 9.1 IL6 IL17A CXCL8 CXCL6 CSF2 CCL5

Sources for Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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