MCID: MST005
MIFTS: 52

Mastitis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Mastitis

MalaCards integrated aliases for Mastitis:

Name: Mastitis 12 54 44 15 17 70
Inflammation of Non-Human Mammary Gland 70
Inflammatory Disorder of Breast 70
Inflammatory Disease of Breast 12
Inflammatory Breast Disease 12
Breast Inflammation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10690
MeSH 44 D008413
NCIt 50 C53662
SNOMED-CT 67 155952005
ICD10 32 N61
UMLS 70 C0024894 C3495439 C3668816

Summaries for Mastitis

Disease Ontology : 12 A breast disease characterized by painful infection of the breast tissue.

MalaCards based summary : Mastitis, also known as inflammation of non-human mammary gland, is related to breast abscess and toxic shock syndrome, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hydrocortisone acetate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include breast, neutrophil and skin, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 73 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...

Related Diseases for Mastitis

Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 551)
# Related Disease Score Top Affiliating Genes
1 breast abscess 32.2 OXT MUC1
2 toxic shock syndrome 32.2 TLR2 LBP IL6 CXCL8
3 erythema nodosum 31.3 NOD2 IL6 CXCL8
4 bacterial infectious disease 31.0 TLR2 NOD2 LTF LBP IL6 IL17A
5 disease by infectious agent 30.9 TLR2 NOD2 LBP IL6 IL17A ALB
6 brucellosis 30.9 IL6 IL17A CXCL8
7 endometritis 30.8 TLR2 OXT IL6 CXCL8
8 neutropenia 30.7 IL6 CXCL8 CP ALB
9 diarrhea 30.7 NOD2 IL6 CXCL8 ALB
10 exanthem 30.6 IL6 CXCL8 ALB
11 leptospirosis 30.6 TLR2 IL6 CXCL8
12 pulmonary tuberculosis 30.5 TLR2 IL6 CP ALB
13 oral candidiasis 30.5 SLPI LTF IL17A CXCL8
14 mycobacterium abscessus 30.5 TLR2 CXCL8
15 candidiasis 30.5 TLR2 IL6 IL17A CXCL8
16 chlamydia 30.5 TLR2 IL6 IL17A CXCL8
17 allergic disease 30.4 TLR2 IL6 CXCL8 CCL5
18 necrotizing fasciitis 30.4 IL6 CXCL8 ALB
19 proteasome-associated autoinflammatory syndrome 1 30.4 TLR2 IL6 IL17A CXCL8 CCL5 ALB
20 immune deficiency disease 30.4 TLR2 STAT5A SLPI IL6 IL17A CCL5
21 gastroenteritis 30.4 IL6 CXCL8 ALB
22 peritonitis 30.4 TLR2 LBP IL6 CXCL8 ALB
23 systemic autoimmune disease 30.4 IL6 IL17A
24 skin disease 30.4 TLR2 IL6 IL17A CXCL8 ALB
25 aspergillosis 30.4 TLR2 NOD2 IL6 CXCL8 CCL5
26 dermatitis 30.3 TLR2 NOD2 IL6 IL17A CXCL8 CCL5
27 infective endocarditis 30.3 TLR2 LBP IL6 IL17A
28 reactive arthritis 30.3 TLR2 LTF LBP IL6 IL17A CXCL8
29 rhinitis 30.3 IL6 IL17A CXCL8 CCL5
30 endocarditis 30.3 TLR2 LBP IL6 IL17A CXCL8 ALB
31 haemophilus influenzae 30.3 TLR2 LTF CXCL8
32 mycobacterium kansasii 30.3 TLR2 CXCL8
33 pasteurellosis 30.2 SLPI CXCL8 ALB
34 type 1 diabetes mellitus 30.2 IL6 IL17A CXCL8 CSN2 ALB
35 relapsing polychondritis 30.2 IL6 IL17A CXCL8
36 echinococcosis 30.2 TLR2 IL6 IL17A
37 pain agnosia 30.2 OXT IL6 ALB
38 acute cystitis 30.2 IL6 CXCL8 ALB
39 arthritis 30.2 TLR2 NOD2 IL6 IL17A CXCL8 CXCL6
40 endophthalmitis 30.2 TLR2 IL6 CXCL8 ALB
41 meningoencephalitis 30.1 IL6 CCL5 ALB
42 alpha-1-antitrypsin deficiency 30.1 SLPI CXCL8 ALB
43 cholangitis 30.1 NOD2 IL6 CXCL8 ALB
44 osteomyelitis 30.1 TLR2 NOD2 IL6 CXCL8
45 sclerosing cholangitis 30.1 NOD2 IL6 CXCL8 ALB
46 systemic lupus erythematosus 30.1 TLR2 NOD2 LTF IL6 IL17A CXCL8
47 vaginal discharge 30.1 SLPI OXT IL6 CXCL8 ALB
48 allergic asthma 30.1 TLR2 IL17A CXCL8 CCL5
49 connective tissue disease 30.1 MUC1 IL6 IL17A CXCL8 ALB
50 uveitis 30.0 NOD2 IL6 IL17A CXCL8

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis

Symptoms & Phenotypes for Mastitis

UMLS symptoms related to Mastitis:


signs and symptoms in breast

MGI Mouse Phenotypes related to Mastitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 A2M ALB CP CXCL6 IL17A IL6
2 immune system MP:0005387 9.4 ALB CCL5 CP CXCL6 IL17A IL6

Drugs & Therapeutics for Mastitis

Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Dermatologic Agents Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Hydrocortisone-17-butyrate Phase 4
7 Hydrocortisone hemisuccinate Phase 4
8 Hydrocortisone 17-butyrate 21-propionate Phase 4
9 Anti-Asthmatic Agents Phase 4
10 Respiratory System Agents Phase 4
11 glucocorticoids Phase 4
12 Hormone Antagonists Phase 4
13 Hormones Phase 4
14 Betamethasone Valerate Phase 4 2152-44-5
15 Betamethasone benzoate Phase 4
16 Betamethasone sodium phosphate Phase 4
17 Betamethasone-17,21-dipropionate Phase 4
18
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
19
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
20
Cefdinir Approved Phase 2, Phase 3 91832-40-5 6915944
21 Clavulanic Acids Phase 2, Phase 3
22 beta-Lactamase Inhibitors Phase 2, Phase 3
23 Lactams Phase 2, Phase 3
24 beta-Lactams Phase 2, Phase 3
25 Antibiotics, Antitubercular Phase 2, Phase 3
26 Anti-Bacterial Agents Phase 2, Phase 3
27 Anti-Infective Agents Phase 2, Phase 3
28 Cephalosporins Phase 2, Phase 3
29 Antitubercular Agents Phase 2, Phase 3
30
Methotrexate Approved 1959-05-2, 59-05-2 126941
31
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
32
Prednisolone acetate Approved, Vet_approved 52-21-1
33
Methylprednisolone Approved, Vet_approved 83-43-2 6741
34
Prednisolone Approved, Vet_approved 50-24-8 5755
35
Methylprednisolone hemisuccinate Approved 2921-57-5
36
Prednisolone phosphate Approved, Vet_approved 302-25-0
37
Cefadroxil Approved, Vet_approved, Withdrawn 66592-87-8, 50370-12-2 47965 2610
38
Acetaminophen Approved 103-90-2 1983
39
Oxytocin Approved, Vet_approved 50-56-6 53477758 439302
40
Ceftriaxone Approved 73384-59-5 5479530 5361919
41
Triamcinolone Approved, Vet_approved 124-94-7 31307
42
Prednisone Approved, Vet_approved 53-03-2 5865
43
Lidocaine Approved, Vet_approved 137-58-6 3676
44
Iodine Approved, Investigational 7553-56-2 807
45
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
46
Prednisolone hemisuccinate Experimental 2920-86-7
47
Imidacloprid Vet_approved 105827-78-9 86418
48
Cadexomer iodine Experimental 94820-09-4
49 Chlorhexidine gluconate
50 Contraceptives, Oral

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Unknown status NCT02959580 Phase 4 Hydrocortisone Butyrate
2 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
3 Phase 2/3 Evaluation of Three Lactobacilli Strains Isolated From Human Milk for the Treatment of Infectious Mastitis During the Lactation Period Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
4 The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis With Three Groups in Randomized Controlled Trial. Recruiting NCT03756324 Phase 2, Phase 3 CHPM (Chinese Herbal Patent Medicine );Antibiotics Cefdinir Capsules;Antibiotics Cefdinir Capsules
5 Oral Administration of a Probiotic Strain to Pregnant Women: Effects on the Prevention of Lactational Mastitis and on the Eradication of GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
6 Early Screening of Breast Cancer Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
7 Study of Intervention Nutritional, Multicenter, Randomized, Blind, Parallel Group to Evaluate the Efficacy of Lactobacillus Fermentum CECT5716 to Reduce the Load Bacterial in Potential Pathogens in Milk of Mothers With Breast Pain Completed NCT02093338
8 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
9 Evaluation of Serum Cytokine Values in Patients With Granulomatous Mastitis Completed NCT04540237
10 Evaluation of Immune Cells in Patients With Granulomatous Mastitis Completed NCT04543149
11 Comparison of the Efficiency of Systemic Therapy and Intralesional Steroid Administration in the Treatment of Idiopathic Granulomatous Mastitis Completed NCT04596046
12 Effectiveness of a Nursing Education Intervention on Duration of Breastfeeding and on Post-natal Breast Complications in Primiparous Women: a Randomized Controlled Trial Completed NCT02106026
13 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
14 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis: A Large Prospective Study Completed NCT00620984
15 Nutritional Intervention Study, Randomized, Double-blind, Parallel Group to Evaluate the Effect of Lactobacillus Fermentum CECT5716 Consumption on the Incidence of Mastitis Completed NCT02203877
16 A RCT in Sweden of Acupuncture and Care Interventions for the Relief of Inflammatory Symptoms of the Breast During Lactation Completed NCT00405158 Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
17 Oral Administration of a Probiotic to Lactating Women: Microbiological, Immunological, Transcriptomics and Metabolomics Effects Completed NCT01124448
18 Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty: A New Paradigm for Tackling Infant Stunting Completed NCT02755012
19 Physical Therapy Intervention for Puerperal Mastitis in Breastfeeding Women Recruiting NCT04569136
20 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Recruiting NCT03724903 Corticosteroid therapy
21 Efficacy of an Educational Intervention in Pregnant Adolescents for the Maintenance of Exclusive Breastfeeding Recruiting NCT04655846
22 Fruit and Vegetable Intervention in Lactating Women to Reduce Breast Cancer Risk: Effects on Breast Cell DNA Methylation, Breast Inflammation,and Weight Recruiting NCT04374747
23 Randomized Controlled Trial for 'Focus Clearing + Whole Breast Exploration and Washing + One-Stage Micro Plastic Surgery' Treatment for Granulomatous Lobular Mastitis Recruiting NCT04637711
24 Multicenter, Randomized, Double-blind, Controlled Parallel Nutritional Intervention Study to Evaluate the Effect of Consumption During Pregnancy and the Lactation Period of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Recruiting NCT04032899
25 Traditional and Complementary Medicine: a Cure for Idiopathic Granulomatous Mastitis? Active, not recruiting NCT04096300
26 Idiopathic Granulomatous Mastitis Not yet recruiting NCT04424615

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

Genetic Tests for Mastitis

Anatomical Context for Mastitis

MalaCards organs/tissues related to Mastitis:

40
Breast, Neutrophil, Skin, Liver, Endothelial, Placenta, T Cells

Publications for Mastitis

Articles related to Mastitis:

(show top 50) (show all 12883)
# Title Authors PMID Year
1
Crosstalk between coagulation and inflammation in mastitis and metritis in dairy cows. 54 61
19584041 2009
2
Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli intramammary infection. 61 54
16954396 2006
3
Biosensor assay for determination of haptoglobin in bovine milk. 61 54
16569277 2006
4
A new diagnostic indicator using concanavalin a low-affinity lactoferrin levels in mammary gland secretion in mastitic drying cows. 54 61
16462118 2006
5
Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. 61 54
15074326 2004
6
Indicators of inflammation in the diagnosis of mastitis. 54 61
14556695 2003
7
[Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions?]. 54 61
12161968 2002
8
Acute phase response in naturally occurring coliform mastitis. 54 61
11459016 2001
9
Acute phase proteins in serum and milk from dairy cows with clinical mastitis. 54 61
11202551 2001
10
Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels. 54 61
11252382 2001
11
Mastitis and transmission of human immunodeficiency virus through breast milk. 54 61
11131699 2000
12
Mastitis and immunological factors in breast milk of lactating women in Malawi. 54 61
10473515 1999
13
Factors contributing to variation in the proportion of casein in cows' milk true protein: a review of recent INRA experiments. 54 61
9718491 1998
14
Reduced lactational performance following intravenous endotoxin administration to dairy cows. 54 61
1744270 1991
15
Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review. 61
33509059 2021
16
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction. 61
33676053 2021
17
Clinical therapeutic evaluation of vacuum sealing drainage and precise ultrasound-guided debridement in the treatment of non-lactational mastitis. 61
33767775 2021
18
Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB. 61
33578236 2021
19
Proofs for genotype by environment interactions considering pedigree and genomic data from organic and conventional cow reference populations. 61
33589254 2021
20
Knowledge and use of antibiotics among low-income small-scale farmers of Peru. 61
33677408 2021
21
Magnetic resonance imaging in the evaluation of pathologic nipple discharge: indications and imaging findings. 61
33544650 2021
22
Prioritizing smallholder animal health needs in East Africa, West Africa, and South Asia using three approaches: Literature review, expert workshops, and practitioner surveys. 61
33581421 2021
23
Observed and expected combined effects of metritis and other postpartum diseases on time to conception and rate of conception failure in first lactation cows in Iran. 61
33540368 2021
24
Feasibility of the use of deep learning classification of teat-end condition in Holstein cattle. 61
33589251 2021
25
Prepartum behavior changes in dry Holstein cows at risk of postpartum diseases. 61
33516551 2021
26
Risk and success factors for good udder health of early lactation primiparous dairy cows. 61
33551155 2021
27
Genus Lilium: A review on traditional uses, phytochemistry and pharmacology. 61
33485985 2021
28
Comparison of the response of mammary gland tissue from two divergent lines of goat with high and low milk somatic cell scores to an experimental Staphylococcus aureus infection. 61
33640660 2021
29
Patients with idiopathic granulomatous mastitis accompanied by erythema nodosum. 61
33305438 2021
30
Multilocus sequence typing of pathogenic Mycoplasma mycoides subsp. capri reveals the predominance of a novel clonal complex among isolates from goats in India. 61
33211173 2021
31
Mycoplasmas bovis P48 induces apoptosis in EBL cells via an endoplasmic reticulum stress-dependent signaling pathway. 61
33676093 2021
32
Molecular epidemiology, antimicrobial activity, and virulence gene clustering of Streptococcus agalactiae isolated from dairy cattle with mastitis in China. 61
33551160 2021
33
Short communication: Comparative performance of 3 on-farm culture systems for detection of mastitis pathogens interpreted by trained and untrained observers. 61
33612204 2021
34
Intergenerational cycle of disease: Maternal mastitis is associated with poorer daughter performance in dairy cattle. 61
33612233 2021
35
Technical note: Evaluation of a commercial on-farm milk leukocyte differential tester to identify subclinical mastitis cases in dairy cows. 61
33612234 2021
36
Effects of a mastitis treatment strategy with or without on-farm testing. 61
33663824 2021
37
Immunization with a novel recombinant protein (YidR) reduced the risk of clinical mastitis caused by Klebsiella spp. and decreased milk losses and culling risk after Escherichia coli infections. 61
33612238 2021
38
Association Between Serum Selenium Level and Subclinical Mastitis in Dairy Cattle. 61
32583225 2021
39
Invited review: The role of the blood-milk barrier and its manipulation for the efficacy of the mammary immune response and milk production. 61
33773785 2021
40
Molecular characterization of antimicrobial resistance in Klebsiella pneumoniae isolated from Brazilian dairy herds. 61
33773789 2021
41
[Bilateral erythematous swelling of the breasts in a pregnant patient]. 61
33709244 2021
42
Dynamics of intramammary infections in suckler ewes during early lactation. 61
33663831 2021
43
Application of a dot blot hybridization assay for genotyping Streptococcus uberis from Brazilian dairy herds. 61
33358822 2021
44
Survey of perceptions and attitudes of an international group of veterinarians regarding antibiotic use and resistance on dairy cattle farms. 61
33524793 2021
45
Technical note: Development of a closed-tube isothermal multiple self-matching-initiated amplification assay for visual detection of Staphylococcus aureus in milk samples. 61
33358821 2021
46
vB_EfaS-DELF1, a novel Siphoviridae bacteriophage with highly effective lytic activity against vancomycin-resistant Enterococcus faecalis. 61
33737153 2021
47
Interaction between bovine mammary epithelial cells and planktonic or biofilm Staphylococcus aureus: The bacterial lifestyle determines its internalization ability and the pathogen recognition. 61
33186743 2021
48
Diverse β-lactam antibiotic-resistant bacteria and microbial community in milk from mastitic cows. 61
33587158 2021
49
Effect of therapeutic administration of β-lactam antibiotics on the bacterial community and antibiotic resistance patterns in milk. 61
33741154 2021
50
Tubeimoside I promotes angiogenesis via activation of eNOS-VEGF signaling pathway. 61
33264658 2021

Variations for Mastitis

Expression for Mastitis

Search GEO for disease gene expression data for Mastitis.

Pathways for Mastitis

Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 TLR2 STAT5A SLPI NOD2 MUC1 LTF
2
Show member pathways
13.19 STAT5A NOD2 MUC1 LBP IL6 IL17A
3
Show member pathways
12.71 TLR2 STAT5A IL6 CXCL8 CCL5
4
Show member pathways
12.61 TLR2 NOD2 IL6 CXCL8 CP
5
Show member pathways
12.43 TLR2 STAT5A NOD2 IL6 IL17A
6
Show member pathways
12.23 IL6 CXCL8 CXCL6 CCL5
7
Show member pathways
12.14 TLR2 IL6 IL17A CXCL8 CXCL6
8 12.12 NOD2 IL6 CXCL8 CCL5
9 12.1 TLR2 NOD2 LBP IL6
10
Show member pathways
11.87 TLR2 MUC1 LBP IL6 CXCL8
11 11.81 NOD2 IL6 CXCL6 CCL5
12
Show member pathways
11.73 LBP IL6 A2M
13
Show member pathways
11.69 TLR2 STAT5A IL6 IL17A
14 11.66 IL6 CXCL8 CXCL6
15 11.61 MUC1 LBP IL6 IL17A CXCL8
16 11.58 STAT5A IL6 CXCL8 CSN2
17 11.56 IL6 CXCL8 CCL5
18 11.5 TLR2 IL6 CXCL8
19
Show member pathways
11.5 TLR2 STAT5A IL6 IL17A
20 11.41 TLR2 IL6 CXCL8
21 11.39 IL6 CXCL8 CCL5
22 11.36 STAT5A IL6 CXCL8
23
Show member pathways
11.32 LBP IL6 IL17A CXCL8 CXCL6
24 11.07 TLR2 IL6 IL17A CXCL8 CXCL6 CCL5

GO Terms for Mastitis

Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 SLPI OXT MUC1 LTF LPO LBP
2 extracellular space GO:0005615 9.55 SLPI OXT MUC1 LTF LPO LBP

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.11 TLR2 SLPI NOD2 LTF LBP IL17A
2 inflammatory response GO:0006954 9.97 TLR2 IL6 IL17A CXCL8 CXCL6 CCL5
3 cell-cell signaling GO:0007267 9.95 LALBA IL17A CXCL6 CCL5
4 cellular protein metabolic process GO:0044267 9.94 LTF IL6 CP ALB
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TLR2 NOD2 LTF IL6
6 immune response GO:0006955 9.91 TLR2 SLPI IL6 IL17A CXCL8 CXCL6
7 defense response GO:0006952 9.89 STAT5A NOD2 CXCL8 CXCL6
8 response to lipopolysaccharide GO:0032496 9.88 TLR2 SLPI NOD2 LBP CXCL6
9 cellular response to lipopolysaccharide GO:0071222 9.85 NOD2 LBP IL6 CXCL8 CXCL6
10 cellular response to interleukin-1 GO:0071347 9.84 IL17A CXCL8 CCL5
11 neutrophil chemotaxis GO:0030593 9.83 CXCL8 CXCL6 CCL5
12 chemokine-mediated signaling pathway GO:0070098 9.81 CXCL8 CXCL6 CCL5
13 defense response to Gram-negative bacterium GO:0050829 9.81 LTF LBP IL6 IL17A
14 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.8 LTF CXCL8 CXCL6
15 positive regulation of interleukin-1 beta production GO:0032731 9.79 NOD2 IL6 IL17A
16 lactation GO:0007595 9.77 STAT5A CSN3 CSN2
17 negative regulation of viral genome replication GO:0045071 9.76 SLPI LTF CCL5
18 positive regulation of interleukin-12 production GO:0032735 9.75 TLR2 NOD2 IL17A
19 positive regulation of chemokine production GO:0032722 9.74 TLR2 LBP IL6
20 positive regulation of interleukin-10 production GO:0032733 9.73 TLR2 NOD2 IL6
21 defense response to Gram-positive bacterium GO:0050830 9.72 TLR2 NOD2 LBP IL6 IL17A
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 TLR2 LBP CCL5
23 positive regulation of interleukin-8 production GO:0032757 9.71 TLR2 NOD2 LBP IL6
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.7 NOD2 IL6 IL17A
25 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.67 CXCL8 CCL5
26 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.66 LTF LBP
27 response to molecule of bacterial origin GO:0002237 9.66 TLR2 CXCL8
28 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 LBP
29 positive regulation of interleukin-6 production GO:0032755 9.65 TLR2 NOD2 LBP IL6 IL17A
30 response to peptidoglycan GO:0032494 9.62 NOD2 IL6
31 negative regulation of cysteine-type endopeptidase activity GO:2000117 9.61 LTF CSN2
32 neutrophil activation GO:0042119 9.61 CXCL8 CXCL6 CCL5
33 positive regulation of cellular biosynthetic process GO:0031328 9.55 CXCL8 CCL5
34 positive regulation of tumor necrosis factor production GO:0032760 9.55 TLR2 NOD2 LBP IL6 IL17A
35 cytokine-mediated signaling pathway GO:0019221 9.5 STAT5A MUC1 LBP IL6 IL17A CXCL8
36 defense response to bacterium GO:0042742 9.17 SLPI NOD2 LTF LPO LBP LALBA

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CXCL8 CXCL6 CCL5
2 lipopeptide binding GO:0071723 9.26 TLR2 LBP
3 lipopolysaccharide binding GO:0001530 9.13 TLR2 LTF LBP
4 cytokine activity GO:0005125 9.02 IL6 IL17A CXCL8 CXCL6 CCL5

Sources for Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....