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MCID: MST005
MIFTS: 53

Mastitis

Categories: Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Mastitis

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MalaCards integrated aliases for Mastitis:

Name: Mastitis 11 53 43 14 16 71 75
Inflammatory Breast Disease 11 33
Breast Inflammation 11 33
Inflammation of Non-Human Mammary Gland 71
Inflammatory Disorder of Breast 71
Inflammatory Disease of Breast 11
Acute Nonpuerperal Mastitis 33
Nonpuerperal Mastitis Nos 33
Subacute Mastitis Nos 33
Acute Mastitis Nos 33
Mastitis Nos 33

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:10690
MeSH 43 D008413
NCIt 49 C53662
SNOMED-CT 68 155952005
ICD10 31 N61
UMLS 71 C0024894 C3495439 C3668816
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Summaries for Mastitis

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Disease Ontology: 11 A breast disease characterized by painful infection of the breast tissue.

MalaCards based summary: Mastitis, also known as inflammatory breast disease, is related to breast abscess and toxic shock syndrome, and has symptoms including signs and symptoms in breast An important gene associated with Mastitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Betamethasone and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include breast, neutrophil and skin, and related phenotypes are liver/biliary system and endocrine/exocrine gland

Wikipedia: 75 Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms... more...
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Related Diseases for Mastitis

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Diseases related to Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 731)
# Related Disease Score Top Affiliating Genes
1 breast abscess 32.3 PRL OXT
2 toxic shock syndrome 32.2 TLR2 LBP IL6 CXCL8
3 erythema nodosum 31.3 NOD2 IL6 CXCL8
4 sarcoidosis 1 30.9 NOD2 IL6 IL17A CCL5 ALB
5 endometritis 30.9 TLR2 OXT IL6 CXCL8
6 brucellosis 30.8 IL6 IL17A CXCL8
7 cellulitis 30.8 IL6 IL17A CXCL8 ALB
8 lymphadenitis 30.7 NOD2 IL6 CXCL8
9 diarrhea 30.7 NOD2 IL6 CXCL8 ALB
10 viral infectious disease 30.6 TLR2 MIR21 IL6 IL17A CXCL8 CCL5
11 aspergillosis 30.6 TLR2 SLPI NOD2 IL6 CXCL8 CCL5
12 systemic lupus erythematosus 30.6 TLR2 PRL NOD2 MIR21 LTF IL6
13 gastroenteritis 30.6 IL6 CXCL8 CP ALB
14 chlamydia 30.5 TLR2 IL6 IL17A CXCL8
15 exanthem 30.5 IL6 IL17A CXCL8 ALB
16 pulmonary tuberculosis 30.5 TLR2 IL6 CP ALB
17 infective endocarditis 30.5 IL6 CXCL8 ALB
18 oral candidiasis 30.5 LTF IL6 IL17A
19 fungal infectious disease 30.5 TLR2 IL6 IL17A CXCL8 ALB
20 leptospirosis 30.4 TLR2 LBP IL6 CXCL8
21 reactive arthritis 30.4 LTF LBP IL17A
22 spondyloarthropathy 1 30.4 NOD2 IL6 IL17A
23 pyoderma 30.4 NOD2 IL17A CXCL8
24 proteasome-associated autoinflammatory syndrome 1 30.4 TLR2 IL6 IL17A CXCL8 CCL5 ALB
25 dermatitis 30.4 NOD2 IL6 IL17A CXCL8
26 vasculitis 30.4 LTF IL6 IL17A CXCL8
27 necrotizing fasciitis 30.4 IL6 CXCL8 ALB
28 candidiasis 30.4 TLR2 LTF IL6 IL17A CXCL8
29 type 1 diabetes mellitus 30.4 IL6 IL17A CXCL8 CSN2 CP ALB
30 pharyngitis 30.4 TLR2 IL6 CXCL8
31 septic arthritis 30.4 TLR2 IL6 IL17A CXCL8 ALB
32 extrapulmonary tuberculosis 30.4 TLR2 IL6 IL17A CXCL8 ALB
33 neutropenia 30.3 STAT5A IL6 CXCL8 CP ALB
34 respiratory failure 30.3 MIR21 IL6 IL17A CXCL8 CCL5 ALB
35 uveitis 30.3 NOD2 IL6 IL17A CXCL8
36 allergic disease 30.3 MIR21 LALBA IL6 IL17A CXCL8 CCL5
37 endocarditis 30.3 TLR2 LBP IL6 IL17A CXCL8 ALB
38 allergic asthma 30.3 TLR2 IL17A CXCL8 CCL5
39 arthritis 30.2 TLR2 NOD2 IL6 IL17A CXCL8 ALB
40 haemophilus influenzae 30.2 TLR2 LTF CXCL8
41 mycobacterium kansasii 30.2 TLR2 CXCL8
42 nutritional deficiency disease 30.2 IL6 CP ALB
43 pasteurellosis 30.2 SLPI CXCL8 ALB
44 common cold 30.2 LPO IL6 IL17A CXCL8 CCL5
45 skin disease 30.2 TLR2 NOD2 MIR21 IL6 IL17A CXCL8
46 immune deficiency disease 30.1 TLR2 STAT5A SLPI MIR21 IL6 IL17A
47 lactocele 30.1 PRL OXT
48 postpartum depression 30.1 PRL OXT IL6
49 peritonitis 30.1 TLR2 NOD2 LBP IL6 IL17A CXCL8
50 headache 30.1 PRL CXCL8 ALB

Comorbidity relations with Mastitis via Phenotypic Disease Network (PDN):


Acute Cystitis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Microglandular Adenosis

Graphical network of the top 20 diseases related to Mastitis:



Diseases related to Mastitis
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Symptoms & Phenotypes for Mastitis

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UMLS symptoms related to Mastitis:


signs and symptoms in breast

MGI Mouse Phenotypes related to Mastitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.96 ALB CP IL17A IL6 LBP LPO
2 endocrine/exocrine gland MP:0005379 9.93 ALB CSN2 CSN3 IL17A IL6 LALBA
3 immune system MP:0005387 9.8 ALB CCL5 CP CXCL6 IL17A IL6
4 integument MP:0010771 9.32 CSN2 CSN3 IL17A IL6 LALBA LPO
Sources

Drugs & Therapeutics for Mastitis

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Drugs for Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2 Anti-Asthmatic Agents Phase 4
3 Betamethasone-17,21-dipropionate Phase 4
4
Betamethasone Valerate Phase 4 2152-44-5
5
Betamethasone sodium phosphate Phase 4
6
Betamethasone benzoate Phase 4
7 Respiratory System Agents Phase 4
8 Hydrocortisone-17-butyrate Phase 4
9 Dermatologic Agents Phase 4
10
Cefdinir Approved Phase 2, Phase 3 91832-40-5 6915944
11
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
12
Clavulanic acid Approved, Vet_approved Phase 2, Phase 3 58001-44-8 5280980
13
Cloxacillin Approved, Investigational, Vet_approved Phase 2, Phase 3 61-72-3 6098
14 Cephalosporins Phase 2, Phase 3
15 Antitubercular Agents Phase 2, Phase 3
16 Anti-Bacterial Agents Phase 2, Phase 3
17 Antibiotics, Antitubercular Phase 2, Phase 3
18 beta-Lactams Phase 2, Phase 3
19 beta-Lactamase Inhibitors Phase 2, Phase 3
20 Lactams Phase 2, Phase 3
21 Acidophilus Phase 2, Phase 3
22 Anti-Infective Agents Phase 2, Phase 3
23
Chlorhexidine Approved, Vet_approved, Withdrawn 55-56-1 2713 9552079
24
Cefadroxil Approved, Vet_approved, Withdrawn 66592-87-8, 50370-12-2 47965
25
Flucloxacillin Approved, Investigational 5250-39-5, 34214-51-2 21319
26
Acetaminophen Approved 103-90-2 1983
27
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
28
Hydrocortisone succinate Approved 2203-97-6 3643
29
Hydrocortisone acetate Approved, Vet_approved 50-03-3
30
Hydrocortisone Approved, Vet_approved 50-23-7 3640 5754
31
Iodine Approved, Investigational 7553-56-2 807
32
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
33
Ceftriaxone Approved 73384-59-5 5479530
34
Lidocaine Approved, Vet_approved 137-58-6 3676
35
Prednisolone phosphate Approved, Vet_approved 302-25-0
36
Prednisolone acetate Approved, Vet_approved 52-21-1
37
Prednisolone Approved, Vet_approved 50-24-8 4894 5755
38
Triamcinolone Approved, Vet_approved 124-94-7 31307
39
Methylprednisolone hemisuccinate Approved 2921-57-5 1875
40
Methylprednisolone Approved, Vet_approved 83-43-2 4159 6741
41
Methotrexate Approved 1959-05-2, 59-05-2 4112 126941
42
Prednisone Approved, Vet_approved 53-03-2 5865
43
Esomeprazole Approved, Investigational, Vet_approved 73590-58-6, 119141-88-7 9568614 4594
44
Cadexomer iodine Experimental 94820-09-4
45
Prednisolone hemisuccinate Experimental 2920-86-7 4897
46 Contraceptives, Oral
47 Contraceptive Agents
48 Chlorhexidine gluconate
49 Interferon alpha-2
50 Interleukin-12

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Unknown status NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
2 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Unknown status NCT02959580 Phase 4 Hydrocortisone Butyrate
3 The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis With Three Groups in Randomized Controlled Trial. Unknown status NCT03756324 Phase 2, Phase 3 CHPM (Chinese Herbal Patent Medicine );Antibiotics Cefdinir Capsules
4 Phase 2/3 Evaluation of Three Lactobacilli Strains Isolated From Human Milk for the Treatment of Infectious Mastitis During the Lactation Period Completed NCT00716183 Phase 2, Phase 3 Beta-lactam antibiotic
5 Oral Administration of a Probiotic Strain to Pregnant Women: Effects on the Prevention of Lactational Mastitis and on the Eradication of GBS Colonization Unknown status NCT01505361 Phase 1, Phase 2
6 A Single Arm Study of Traditional Chinese Medicine for Treatment of Plasma Cell Mastitis Recruiting NCT05530226 Phase 2 Traditional Chinese medicine
7 Traditional and Complementary Medicine: a Cure for Idiopathic Granulomatous Mastitis? Unknown status NCT04096300
8 Idiopathic Granulomatous Mastitis Unknown status NCT04424615
9 Multicenter, Randomized, Double-blind, Controlled Parallel Nutritional Intervention Study to Evaluate the Effect of Consumption During Pregnancy and the Lactation Period of Lactobacillus Fermentum CECT5716 on the Incidence of Mastitis Unknown status NCT04032899
10 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
11 Comparison of the Efficiency of Systemic Therapy and Intralesional Steroid Administration in the Treatment of Idiopathic Granulomatous Mastitis Completed NCT04596046
12 Evaluation of Serum Cytokine Values in Patients With Granulomatous Mastitis Completed NCT04540237
13 Evaluation of Immune Cells in Patients With Granulomatous Mastitis Completed NCT04543149
14 Evaluating the Risk Factors and the Role of Albumin-to-globulin Ratio in Predicting Recurrence Among Patients With Idiopathic Granulomatous Mastitis Completed NCT05409586
15 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
16 Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis: A Large Prospective Study Completed NCT00620984
17 Nutritional Intervention Study, Randomized, Double-blind, Parallel Group to Evaluate the Effect of Lactobacillus Fermentum CECT5716 Consumption on the Incidence of Mastitis Completed NCT02203877
18 A RCT in Sweden of Acupuncture and Care Interventions for the Relief of Inflammatory Symptoms of the Breast During Lactation Completed NCT00405158 Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
19 Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty: A New Paradigm for Tackling Infant Stunting Completed NCT02755012
20 Oral Administration of a Probiotic to Lactating Women: Microbiological, Immunological, Transcriptomics and Metabolomics Effects Completed NCT01124448
21 Identification of Predictive Biomarkers of Mastitis in Lactating Mothers Using a Metabolomic Approach Recruiting NCT05021042
22 The Effect of the Combination of Excision and Intraoperative Steroid Administration in Idiopathic Granulomatous Mastitis Recruiting NCT05361629
23 Alterations in the Gut Microbiota and Metabolite Profiles of Nonpuerperal Mastitis Patients Recruiting NCT05051215
24 Randomized Controlled Trial for 'Focus Clearing + Whole Breast Exploration and Washing + One-Stage Micro Plastic Surgery' Treatment for Granulomatous Lobular Mastitis Recruiting NCT04637711
25 Physical Therapy Intervention for Puerperal Mastitis in Breastfeeding Women Recruiting NCT04569136
26 Combined Intralesional Triamcinolone Injection With Whole Breast Detection Radical Surgery in Treating Refractory Granulomatous Lobular Mastitis: A Randomized Controlled Trial Recruiting NCT05281419
27 The Guidance on the Gravitationally Assisted Lactation Influences the Occurrence of Lactational Mastitis: a Clinical Cohort Study Recruiting NCT05207241
28 Osteopathic Manipulative Treatment for Recurrent Mastitis Recruiting NCT05132426
29 Fruit and Vegetable Intervention in Lactating Women to Reduce Breast Cancer Risk: Effects on Breast Cell DNA Methylation, Breast Inflammation,and Weight Recruiting NCT04374747
30 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Active, not recruiting NCT03724903 Corticosteroid therapy
31 A Randomized Controlled Study of Conservative Treatment of Granulomatous Lobular Mastitis Combined With Psychiatric Disorders Enrolling by invitation NCT05395949 conservative treatment

Search NIH Clinical Center for Mastitis

Cochrane evidence based reviews: mastitis

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Genetic Tests for Mastitis

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Anatomical Context for Mastitis

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Organs/tissues related to Mastitis:

MalaCards : Breast, Neutrophil, Skin, T Cells, Endothelial, Lymph Node, Placenta
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Publications for Mastitis

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Articles related to Mastitis:

(show top 50) (show all 14207)
# Title Authors PMID Year
1
Crosstalk between coagulation and inflammation in mastitis and metritis in dairy cows. 53 62
19584041 2009
2
Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli intramammary infection. 53 62
16954396 2006
3
Biosensor assay for determination of haptoglobin in bovine milk. 53 62
16569277 2006
4
A new diagnostic indicator using concanavalin a low-affinity lactoferrin levels in mammary gland secretion in mastitic drying cows. 53 62
16462118 2006
5
Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. 53 62
15074326 2004
6
Indicators of inflammation in the diagnosis of mastitis. 53 62
14556695 2003
7
[Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions?]. 53 62
12161968 2002
8
Acute phase response in naturally occurring coliform mastitis. 53 62
11459016 2001
9
Acute phase proteins in serum and milk from dairy cows with clinical mastitis. 53 62
11202551 2001
10
Recombinant human protein C expression in the milk of transgenic pigs and the effect on endogenous milk immunoglobulin and transferrin levels. 53 62
11252382 2001
11
Mastitis and transmission of human immunodeficiency virus through breast milk. 53 62
11131699 2000
12
Mastitis and immunological factors in breast milk of lactating women in Malawi. 53 62
10473515 1999
13
Factors contributing to variation in the proportion of casein in cows' milk true protein: a review of recent INRA experiments. 53 62
9718491 1998
14
Reduced lactational performance following intravenous endotoxin administration to dairy cows. 53 62
1744270 1991
15
Granulomatous mastitis (GM) in a young woman with a previous history of prolactin-secreting PitNET and actual normal prolactinemia. 62
36457793 2023
16
Mammography and Digital Breast Tomosynthesis in Granulomatous and Nongranulomatous Mastitis. 62
36108534 2023
17
Human Milk Sodium and Potassium as Markers of Mastitis in Mothers of Preterm Infants. 62
36378839 2022
18
Diversity and emergence of multi-resistant Staphylococcus spp. isolated from subclinical mastitis in cows in of the state of Piauí, Brazil. 62
36074251 2022
19
Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1. 62
36399659 2022
20
Novel aadA5 and dfrA17 variants of class 1 integron in multidrug-resistant Escherichia coli causing bovine mastitis. 62
36454252 2022
21
Management of Mastitis, Abscess, and Fistula. 62
36335928 2022
22
AMPK/Drp1 pathway mediates Streptococcus uberis-Induced mitochondrial dysfunction. 62
36461586 2022
23
Gut dysbiosis induces the development of mastitis through a reduction in host anti-inflammatory enzyme activity by endotoxemia. 62
36451232 2022
24
Isolation of Lactococcus garvieae NEP21 from raw cow (Bos indicus) milk in Nepal. 62
36470377 2022
25
MAC mediates mammary duct epithelial cell injury in plasma cell mastitis and granulomatous mastitis. 62
36252469 2022
26
Benign Breast Disease: Periareolar Mastitis, Granulomatous Lobular Mastitis, and Lymphocytic or Diabetic Mastopathy. 62
36335921 2022
27
Spray-drying-microencapsulated Minthostachys verticillata essential oil and limonene as innovative adjuvant strategy to bovine mastitis vaccines. 62
35792419 2022
28
Research progress on the association between mastitis and gastrointestinal microbes in dairy cows and the effect of probiotics. 62
36183956 2022
29
Udder health, veterinary costs, and antibiotic usage in free stall compared with tie stall dairy housing systems: An optimized matching approach in Switzerland. 62
36096032 2022
30
Tanshinone IIa alleviates LPS-induced oxidative stress in dairy cow mammary epithelial cells by activating the Nrf2 signalling pathway. 62
36027684 2022
31
The anti-apoptotic and anti-autophagic effects of EPO through PI3K/Akt/mTOR signaling pathway in MAC-T cells. 62
35714559 2022
32
Association of pre-treatment somatic cell counts with bacteriological cure following diagnosis of intramammary infection. 62
36179547 2022
33
Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock. 62
36469788 2022
34
Effect of temporary cessation of milking and estradiol combination on the antimicrobial components in goat milk. 62
36108551 2022
35
Sensitivity and specificity of bacterial culture, qPCR, and somatic cell count for detection of goats with Staphylococcus aureus intramammary infection using Bayesian latent class models. 62
36327775 2022
36
[Streptococcus agalactiae late onset infection associated with human milk: three cases report]. 62
36374063 2022
37
Swarming Magnetic Microrobots for Pathogen Isolation from Milk. 62
36475385 2022
38
Genome-wide post-transcriptional regulation of bovine mammary gland response to Streptococcus uberis. 62
36066834 2022
39
The prevalence and species of Mycoplasma identified from dairy goats in Taiwan. 62
36049268 2022
40
A systematic literature review on the economic impact of endemic disease in UK sheep and cattle using a One Health conceptualisation. 62
36332284 2022
41
β-carotene alleviates LPS-induced inflammation through regulating STIM1/ORAI1 expression in bovine mammary epithelial cells. 62
36334371 2022
42
Management of Common Complications of Lactation: The Breast Surgeon's Role in Examining the Science and Debunking Old Myths. 62
36335932 2022
43
Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway. 62
36243161 2022
44
Comparative secretome analysis of Staphylococcus aureus strains with different within-herd intramammary infection prevalence. 62
35030987 2022
45
Genetic diversity and iron metabolism of Staphylococcus hominis isolates originating from bovine quarter milk, rectal feces, and teat apices. 62
36270870 2022
46
Dairy production sustainability through a one-health lens. 62
36374578 2022
47
Differential immune response to two Staphylococcus aureus strains with distinct adaptation genotypes after experimental intramammary infection of dairy cows. 62
36176246 2022
48
The Effect of Pegbovigrastim Injection on Phagocytic and Oxidative Burst Activities of Peripheral Blood Granulocytes and Monocytes in Calves Challenged with Mycoplasma bovis. 62
36365068 2022
49
Characteristics of a novel temperate bacteriophage against Staphylococcus arlettae (vB_SarS_BM31). 62
36336729 2022
50
Current Attitudes of Chinese Dairy Practitioners to Pain and Its Management in Intensively Raised Dairy Cattle. 62
36428368 2022
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Variations for Mastitis

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Expression for Mastitis

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Search GEO for disease gene expression data for Mastitis.
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Pathways for Mastitis

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Pathways related to Mastitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.59 CCL5 CXCL8 IL17A IL6 LBP LPO
2
Akt Signaling 64
Show member pathways
 13.31 TLR2 STAT5A IL6 IL17A CXCL8 CXCL6
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.05 STAT5A PRL NOD2 LBP IL6 IL17A
4
Toll-like receptor signaling pathway 74
Show member pathways
 12.68 CCL5 CXCL8 IL6 LBP STAT5A TLR2
5
Toll-Like receptor Signaling Pathways 65
Show member pathways
 12.4 TLR2 NOD2 IL6 CXCL8
6
Bacterial infections in CF airways 22
Show member pathways
 12.31 TLR2 LBP IL6 CXCL8
7
IL-17 Family Signaling Pathways 65
Show member pathways
 12.14 TLR2 IL6 IL17A CXCL8
8
Interleukin-4 and Interleukin-13 signaling 66
11.74 LBP IL6 IL17A CXCL8
9
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.65 LBP IL6 CXCL8
10
IL27-mediated signaling events 61
Show member pathways
 11.62 TLR2 STAT5A IL6 IL17A
11
Th17 cell differentiation pathway 74
11.6 IL17A IL6 STAT5A
12
Lung fibrosis 74
11.55 IL6 CXCL8 CCL5
13
miRNAs involvement in the immune response in sepsis 74
11.54 MIR21 IL6 CXCL8
14
Inflammatory bowel disease signaling 74
Show member pathways
 11.5 TLR2 NOD2 IL6
15
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.42 NOD2 IL6 CXCL8
16
Th17 Differentiation 65
Show member pathways
 11.42 TLR2 STAT5A IL6 IL17A
17
Interleukin-10 signaling 66
11.36 IL6 CXCL8 CCL5
18
Signaling events mediated by PTP1B 61
11.33 STAT5A PRL CSN2
19
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.32 LBP IL6 IL17A CXCL8 CXCL6
20
Prostaglandin signaling 74
11.08 IL6 IL17A CXCL8
21
Immune infiltration in pancreatic cancer 74
11.04 IL6 IL17A CXCL8
22
G-protein signaling_Rap2B regulation pathway 22
10.92 IL6 IL17A CXCL8 CXCL6 CCL5
23
Glucocorticoid receptor regulatory network 61
10.91 STAT5A PRL IL6 CXCL8 CSN2
24
COVID-19 adverse outcome pathway 74
10.61 IL6 CXCL8
25
Cells and molecules involved in local acute inflammatory response 74
Show member pathways
 10.22 IL6 CXCL8
Sources

GO Terms for Mastitis

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Cellular components related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.15 ALB CCL5 CP CSN2 CSN3 CXCL6
2 extracellular space GO:0005615 9.84 ALB CCL5 CP CSN2 CSN3 CXCL6

Biological processes related to Mastitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.34 TLR2 IL6 IL17A CXCL8 CXCL6 CCL5
2 immune response GO:0006955 10.19 TLR2 SLPI IL6 IL17A CXCL8 CXCL6
3 defense response to Gram-negative bacterium GO:0050829 10.14 LTF LBP IL6 IL17A
4 neutrophil chemotaxis GO:0030593 10.13 LBP CXCL8 CXCL6 CCL5
5 positive regulation of interleukin-8 production GO:0032757 10.11 IL6 LBP NOD2 TLR2
6 positive regulation of chemokine production GO:0032722 10.09 TLR2 LBP IL6
7 negative regulation of viral genome replication GO:0045071 10.09 SLPI LTF CCL5
8 positive regulation of interleukin-12 production GO:0032735 10.08 IL17A NOD2 TLR2
9 positive regulation of interleukin-10 production GO:0032733 10.08 TLR2 NOD2 IL6
10 immune system process GO:0002376 10.07 TLR2 SLPI NOD2 LTF LBP IL17A
11 lipopolysaccharide-mediated signaling pathway GO:0031663 10.06 TLR2 LBP CCL5
12 defense response to Gram-positive bacterium GO:0050830 10.06 TLR2 NOD2 LBP IL6 IL17A
13 defense response GO:0006952 10.05 CXCL6 CXCL8 NOD2 STAT5A
14 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.04 PRL IL6 CCL5
15 positive regulation of tumor necrosis factor production GO:0032760 10.02 IL17A IL6 LBP NOD2 TLR2
16 response to lipopolysaccharide GO:0032496 10 CXCL6 LBP NOD2 SLPI TLR2
17 lactation GO:0007595 9.97 STAT5A PRL CSN3 CSN2
18 positive regulation of interleukin-6 production GO:0032755 9.96 TLR2 NOD2 LBP IL6 IL17A
19 neutrophil activation GO:0042119 9.95 CXCL8 CXCL6 CCL5
20 toll-like receptor 2 signaling pathway GO:0034134 9.93 TLR2 NOD2
21 cellular response to lipopolysaccharide GO:0071222 9.9 CXCL6 CXCL8 IL6 LBP MIR21 NOD2
22 positive regulation of cellular biosynthetic process GO:0031328 9.85 CCL5 CXCL8
23 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.8 MIR21 IL6
24 response to external stimulus GO:0009605 9.61 TLR2 CXCL8 CXCL6
25 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.5 NOD2 MIR21 IL6 IL17A
26 defense response to bacterium GO:0042742 9.36 SLPI NOD2 LTF LPO LBP LALBA

Molecular functions related to Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.63 CXCL8 CXCL6 CCL5
2 lipopolysaccharide binding GO:0001530 9.43 TLR2 LTF LBP
3 cytokine activity GO:0005125 9.17 IL6 IL17A CXCL8 CXCL6 CCL5
Sources

Sources for Mastitis

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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