MCID: MST019
MIFTS: 34

Mastoiditis

Categories: Bone diseases, Ear diseases

Aliases & Classifications for Mastoiditis

MalaCards integrated aliases for Mastoiditis:

Name: Mastoiditis 12 76 29 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060322
ICD10 33 H70.9 H70.90
ICD9CM 35 383.9
MeSH 44 D008417
NCIt 50 C128368
SNOMED-CT 68 52404001
UMLS 73 C0024904

Summaries for Mastoiditis

Disease Ontology : 12 A middle ear disease characterized by an inflammation of the mucosal lining of the mastoid antrum and the mastoid air cell system inside the mastoid process.

MalaCards based summary : Mastoiditis is related to suppurative otitis media and lemierre's syndrome. An important gene associated with Mastoiditis is MALT1 (MALT1 Paracaspase). The drugs Salmon Calcitonin and Calcitonin gene-related peptide have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and skin, and related phenotype is immune system.

Wikipedia : 76 Mastoiditis is the result of an infection that extends to the air cells of the skull behind the ear. ... more...

Related Diseases for Mastoiditis

Diseases related to Mastoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 374)
# Related Disease Score Top Affiliating Genes
1 suppurative otitis media 31.2 CRP SLC29A3
2 lemierre's syndrome 30.0 CRP MTHFR
3 cholesteatoma of middle ear 12.1
4 auditory system disease 11.6
5 otitis media 11.0
6 trichodentoosseous syndrome 11.0
7 gapo syndrome 11.0
8 immunodeficiency 12 11.0
9 focal labyrinthitis 11.0
10 geniculate ganglionitis 11.0
11 cerebrospinal fluid leak 11.0
12 otitis externa 10.6
13 labyrinthitis 10.5
14 otosclerosis 10.5
15 thrombosis 10.5
16 meniere disease 10.5
17 petrositis 10.4
18 sensorineural hearing loss 10.4
19 patulous eustachian tube 10.4
20 perilymphatic fistula 10.4
21 adhesive otitis media 10.4
22 polyp of middle ear 10.4
23 meningitis 10.4
24 chronic purulent otitis media 10.3
25 otosalpingitis 10.3
26 facial paralysis 10.3
27 lateral sinus thrombosis 10.3
28 cholesteatoma of external ear 10.2
29 age-related hearing loss 10.2
30 middle ear carcinoma 10.2
31 orbital disease 10.1 CRP RHNO1
32 lymphoma 10.1
33 sarcoma 10.1
34 rhabdomyosarcoma 10.1
35 scarlet fever 10.1
36 sphenoid sinusitis 10.1 CRP RHNO1
37 ethmoid sinusitis 10.1 CRP RHNO1
38 streptococcal meningitis 10.1 CRP SPEG
39 orbital cellulitis 10.0 CRP RHNO1
40 acoustic neuroma 10.0
41 papilloma 10.0
42 inverted papilloma 10.0
43 acute orbital inflammation 10.0 CRP RHNO1
44 rosai-dorfman disease 10.0 CRP SLC29A3
45 external ear disease 10.0
46 tympanic membrane disease 10.0
47 rhinoscleroma 10.0 RHNO1 SLC29A3
48 aural atresia, congenital 10.0
49 actinomycosis 10.0
50 ischemic neuropathy 10.0 CRP MTHFR

Comorbidity relations with Mastoiditis via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Mastoiditis:



Diseases related to Mastoiditis

Symptoms & Phenotypes for Mastoiditis

MGI Mouse Phenotypes related to Mastoiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 CRP KERA MALT1 SLC29A3 SPEG

Drugs & Therapeutics for Mastoiditis

Drugs for Mastoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
2
Calcitonin gene-related peptide Investigational 83652-28-2
3 Vaccines
4 Immunologic Factors
5 Heptavalent Pneumococcal Conjugate Vaccine
6 calcitonin
7 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Impact of Prevnar 13 on Ear Infections in Children Completed NCT01272999
2 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
3 Is There Hearing Loss After Acute Mastoiditis Withdrawn NCT00502450

Search NIH Clinical Center for Mastoiditis

Cochrane evidence based reviews: mastoiditis

Genetic Tests for Mastoiditis

Genetic tests related to Mastoiditis:

# Genetic test Affiliating Genes
1 Mastoiditis 29

Anatomical Context for Mastoiditis

MalaCards organs/tissues related to Mastoiditis:

41
Bone, Brain, Skin, T Cells, Eye, Heart, Myeloid

Publications for Mastoiditis

Articles related to Mastoiditis:

(show top 50) (show all 650)
# Title Authors Year
1
Cortical mastoidectomy with posterior atticotomy as surgical treatment in cases of acute mastoiditis in children. ( 30528128 )
2019
2
Acute mastoiditis in an Italian pediatric tertiary medical center: a 15 - year retrospective study. ( 29914542 )
2018
3
National Incidence of Pediatric Mastoiditis in the United States, 2000-2012: Creating a Baseline for Public Health Surveillance. ( 29601460 )
2018
4
Acute mastoiditis with subperiosteal abscess due to emerging infectious agents. ( 29398006 )
2018
5
Pediatric recurrent acute mastoiditis: Risk factors and insights into pathogenesis. ( 29958598 )
2018
6
Acute Mastoiditis Complicated with Concomitant Bezold's Abscess and Lateral Sinus Thrombosis. ( 29755803 )
2018
7
Changes in the epidemiology and clinical features of acute mastoiditis following the introduction of the pneumococcal conjugate vaccine. ( 29287882 )
2018
8
Mastoiditis. ( 29716974 )
2018
9
Fusobacterium necrophorum as an Emerging Pathogen of Acute Mastoiditis. ( 29596220 )
2018
10
Safety and postoperative adverse events in management of acute mastoiditis in children - 30 Day NSQIP outcomes. ( 29605342 )
2018
11
Is anticoagulation beneficial in acute mastoiditis complicated by sigmoid sinus thrombosis? ( 29521448 )
2018
12
Non-Hodgkin's Lymphoma of the Middle Ear Presenting as Mastoiditis. ( 30416834 )
2018
13
Therapeutic approach to pediatric acute mastoiditis - an update. ( 30056031 )
2018
14
Cranial Rhabdomyosarcoma Masquerading as Infectious Mastoiditis: Case Report and Literature Review. ( 30145587 )
2018
15
Medical Versus Surgical Treatment of Pediatric Acute Mastoiditis: A Systematic Review. ( 30284265 )
2018
16
Complicated Necrotizing Otitis Externa Progressing to Coalescent Mastoiditis and Temporal Lobe Abscess. ( 30367858 )
2018
17
Incidental mastoiditis on magnetic resonance imaging scans: clinical relevance and cost implications. ( 30392474 )
2018
18
Sonographic diagnosis of acute mastoiditis and subsequent retroauricular abscess in a pediatric cochlear implant recipient: A case report. ( 28369924 )
2017
19
Primary Ewing Sarcoma of the Mastoid: A Novel Case Mimicking Acute Mastoiditis. ( 29176463 )
2017
20
Two clinical cases of granulomatosis with polyangiitis with isolated otitis media and mastoiditis. ( 29332965 )
2017
21
Pediatric acute mastoiditis in the era of pneumococcal vaccination. ( 29105776 )
2017
22
Radiological Imaging of Rare Intracranial Complications Secondary to Otitis Media and Mastoiditis. ( 28468135 )
2017
23
Mastoiditis: on the rise again? ( 28541113 )
2017
24
Radiological Imaging of Rare Intracranial Complications Secondary to Otitis Media and Mastoiditis. ( 28114208 )
2017
25
Management of paediatric acute mastoiditis: systematic review. ( 28879826 )
2017
26
Outpatient management of pediatric acute mastoiditis. ( 29106885 )
2017
27
Differentiating between rhinosinusitis and mastoiditis surgery from postmortem medical training: A study of two identified skulls and hospital records from early 20th century Coimbra, Portugal. ( 28521908 )
2017
28
AA New Classification System is Helpful in Diagnosing Intracranial Complications of Acute Mastoiditis in CT. ( 28801828 )
2017
29
Prognostic effect of pre- and post-admission antibiotic treatment in paediatric acute mastoiditis. ( 27748206 )
2017
30
Acute mastoiditis in children: Middle ear cultures may help in reducing use of broad spectrum antibiotics. ( 28012530 )
2017
31
Clivus erosions following Gradenigo's syndrome-mastoiditis causing VI nerve palsy. ( 26969363 )
2016
32
Acute mastoiditis in children with a cochlear implant. ( 26810295 )
2016
33
Management of acute complicated mastoiditis at an urban, tertiary care pediatric hospital. ( 27796038 )
2016
34
Acute Mastoiditis Caused by Streptococcus pneumoniae. ( 27171806 )
2016
35
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
36
Recurrent Mastoiditis Mimics IgG4 Related Disease: A Potential Diagnostic Pitfall. ( 27091207 )
2016
37
Management of Pediatric Acute Mastoiditis in Israel: Nationwide Survey Among Otorhinolaryngologists and Emergency Pediatricians. ( 27977506 )
2016
38
Predictors of Mastoiditis after Intensity-Modulated Radiotherapy in Nasopharyngeal Carcinoma: A Dose-Volume Analysis. ( 26918040 )
2016
39
Mastoiditis and facial paralysis as initial manifestations of temporal bone systemic diseases - the significance of the histopathological examination. ( 27151715 )
2016
40
Fusobacterium necrophorum otitis and mastoiditis in infants and young toddlers. ( 26951264 )
2016
41
Differentiating Acute Otitis Media and Acute Mastoiditis in Hospitalized Children. ( 27613655 )
2016
42
Severe Acute Otitis Media and Acute Mastoiditis in Adults. ( 27895000 )
2016
43
Sensorineural hearing loss after otitis media with effusion and subacute mastoiditis after viral infections of the upper respiratory tract: A comparative study of conservative and surgical treatment. ( 27657322 )
2016
44
Acute Mastoiditis Before Pneumococcal Vaccination: The Experience of a Large Tertiary Care Pediatric Hospital. ( 25285797 )
2016
45
The Role of Bacteriologic Studies in Predicting Recurrent Mastoiditis in 456 Patients. ( 27466885 )
2016
46
BraA+n abscess due to Streptococcus intermedius secondary to mastoiditis in a child. ( 26722629 )
2015
47
Donovanosis causing lymphadenitis, mastoiditis, and meningitis in a child. ( 26122163 )
2015
48
Dural enhancement and thickening in acute mastoiditis. ( 25963158 )
2015
49
A Novel Radiographic Sign and a New Classifying System in Mastoiditis-Related Epidural Abscess. ( 26275182 )
2015
50
Subperiosteal abscesses in acute mastoiditis in 115 Swedish children. ( 26022749 )
2015

Variations for Mastoiditis

Expression for Mastoiditis

Search GEO for disease gene expression data for Mastoiditis.

Pathways for Mastoiditis

GO Terms for Mastoiditis

Sources for Mastoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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