MCID: MST019
MIFTS: 41

Mastoiditis

Categories: Bone diseases, Ear diseases

Aliases & Classifications for Mastoiditis

MalaCards integrated aliases for Mastoiditis:

Name: Mastoiditis 12 73 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060322
ICD9CM 34 383.9
MeSH 44 D008417
NCIt 50 C128368
SNOMED-CT 67 155230007
ICD10 32 H70.9
UMLS 70 C0024904

Summaries for Mastoiditis

Disease Ontology : 12 A middle ear disease characterized by an inflammation of the mucosal lining of the mastoid antrum and the mastoid air cell system inside the mastoid process.

MalaCards based summary : Mastoiditis is related to facial paralysis and epidural abscess. An important gene associated with Mastoiditis is MALT1 (MALT1 Paracaspase), and among its related pathways/superpathways are NF-kappaB Signaling and Formation of Fibrin Clot (Clotting Cascade). The drugs Triamcinolone and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related phenotype is immune system.

Wikipedia : 73 Mastoiditis is the result of an infection that extends to the air cells of the skull behind the ear.... more...

Related Diseases for Mastoiditis

Diseases related to Mastoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 389)
# Related Disease Score Top Affiliating Genes
1 facial paralysis 31.1 PRTN3 CRP
2 epidural abscess 31.0 F2 CRP
3 lateral sinus thrombosis 30.8 SERPINC1 MTHFR F2
4 pleural empyema 30.8 F2 CRP
5 subdural empyema 30.7 F2 CRP
6 suppurative otitis media 30.7 DOCK8 DHRS2 CRP
7 lemierre's syndrome 30.5 MTHFR F2 CRP
8 otitis externa 30.4 DOCK8 DHX37 CRP
9 intracranial hypertension 30.4 SERPINC1 MTHFR F2
10 frontal sinusitis 30.3 PRTN3 CRP
11 thrombophlebitis 30.3 SERPINC1 MTHFR F2 CRP
12 cerebral sinovenous thrombosis 30.2 MTHFR F2
13 middle ear disease 30.2 PRTN3 MPO DHRS2 CRP
14 papilledema 30.2 SERPINC1 F2 CRP
15 granulomatosis with polyangiitis 30.2 PRTN3 MPO CRP
16 scarlet fever 30.1 SPEG CRP
17 vasculitis 30.1 PRTN3 MPO CRP
18 ethmoid sinusitis 30.1 PRTN3 CRP
19 endocarditis 30.1 SERPINC1 F2 CRP
20 cranial nerve palsy 29.9 SERPINC1 PRTN3 CRP
21 purulent acute otitis media 29.9 PRTN3 MPO CRP
22 subacute bacterial endocarditis 29.9 PRTN3 MPO CRP
23 cavernous sinus thrombosis 29.8 SERPINC1 F2 CRP
24 abducens nerve disease 29.8 SERPINC1 F2 CRP
25 exanthem 29.8 PRTN3 F2 CRP
26 nutritional deficiency disease 29.7 MTHFR F2 CRP
27 intracranial sinus thrombosis 29.5 SERPINC1 MTHFR F2 CRP
28 otitis media 10.9
29 immunodeficiency 12 10.9
30 focal labyrinthitis 10.9
31 thrombosis 10.5
32 cholesteatoma of middle ear 10.5
33 meningitis 10.5
34 anterior scleritis 10.4 PRTN3 CRP
35 orbital plasma cell granuloma 10.4 PRTN3 CRP
36 bicipital tenosynovitis 10.4 PRTN3 CRP
37 tenosynovitis 10.4 PRTN3 CRP
38 posterior scleritis 10.4 PRTN3 CRP
39 tolosa-hunt syndrome 10.4 PRTN3 CRP
40 blue toe syndrome 10.4 SERPINC1 CRP
41 chronic orbital inflammation 10.4 PRTN3 CRP
42 cerebral arteritis 10.4 SERPINC1 CRP
43 petrositis 10.3
44 granulomatous angiitis 10.3 PRTN3 CRP
45 allergic cutaneous vasculitis 10.3 PRTN3 MPO
46 suppurative lymphadenitis 10.3 DOCK8 CRP
47 orbital osteomyelitis 10.3 F2 CRP
48 achenbach syndrome 10.3 F2 CRP
49 small intestine diverticulitis 10.3 F2 CRP
50 cogan syndrome 10.3 PRTN3 CRP

Comorbidity relations with Mastoiditis via Phenotypic Disease Network (PDN):


Otitis Media

Graphical network of the top 20 diseases related to Mastoiditis:



Diseases related to Mastoiditis

Symptoms & Phenotypes for Mastoiditis

MGI Mouse Phenotypes related to Mastoiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CARD11 CRP DOCK8 F2 MALT1 MPO

Drugs & Therapeutics for Mastoiditis

Drugs for Mastoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4 Triamcinolone hexacetonide Phase 4
5 triamcinolone acetonide Phase 4
6 Triamcinolone diacetate Phase 4
7 Anesthetics Phase 4
8 Chlorhexidine gluconate Phase 4
9 Anesthetics, Local Phase 4
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
12 Gastrointestinal Agents Phase 3
13 Hormone Antagonists Phase 3
14 glucocorticoids Phase 3
15 Antiemetics Phase 3
16 Hormones Phase 3
17 Antineoplastic Agents, Hormonal Phase 3
18 Anti-Inflammatory Agents Phase 3
19
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
20
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
21
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
22
Zinc Approved, Investigational Phase 2 7440-66-6 32051
23 Trace Elements Phase 2
24 Alkylating Agents Phase 2
25 Nutrients Phase 2
26 Immunosuppressive Agents Phase 2
27 Immunologic Factors Phase 2
28 Analgesics, Non-Narcotic Phase 2
29 Antirheumatic Agents Phase 2
30 Cyclooxygenase Inhibitors Phase 2
31 Analgesics Phase 2
32 Tocolytic Agents Phase 2
33 Proton Pump Inhibitors Phase 2
34 Antacids Phase 2
35 Micronutrients Phase 2
36 Anti-Ulcer Agents Phase 2
37 Anti-Inflammatory Agents, Non-Steroidal Phase 2
38
Racepinephrine Approved 329-65-7 838
39
Epinephrine Approved, Vet_approved 51-43-4 5816
40
Ropivacaine Approved 84057-95-4 71273 175805
41
Methylcobalamin Approved, Investigational 13422-55-4
42
Dopamine Approved 62-31-7, 51-61-6 681
43
Methylphenidate Approved, Investigational 113-45-1 4158
44
Lidocaine Approved, Vet_approved 137-58-6 3676
45 Heptavalent Pneumococcal Conjugate Vaccine
46 Vaccines
47 Epinephryl borate
48 Pharmaceutical Solutions
49 Central Nervous System Stimulants
50 Dopamine Agents

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Transcranial Alternating Current Stimulation (tACS) Enhances Neurological Function Recovery Among Post-stroke Patients Completed NCT01200719 Phase 4
2 Use of Biodesign® Otologic Graft in Canal Wall Down Mastoidectomy: A Prospective, Randomized Trial Recruiting NCT03902938 Phase 4
3 The Effect of Superficial Cervical Plexus Block on Post-Thoracotomy/Scopy Ipsilateral Shoulder Pain Terminated NCT01550302 Phase 4 Bupivacaine
4 Implications of Electrophysiological ADHD Endophenotypes to Predict Response to Transcranial Direct-Current Stimulation Completed NCT01649232 Phase 3
5 Corticosteroids as an Additional Treatment for Mastoiditis In Children Not yet recruiting NCT04828525 Phase 3 Dexamethasone;normal saline
6 Transcutaneous Vagus Nerve Stimulation for Treating Major Depressive Disorder: a Phase II, Randomized, Double-blind Clinical Trial Unknown status NCT02562703 Phase 1, Phase 2
7 Transcranial Electrical Stimulation for Management of Orthostatic Instability in Acute Cervical Spinal Cord Injury Completed NCT01874782 Phase 2
8 A Phase 2, Open-label Trial of the Safety and Biological Effect of Subcutaneous IRX-2 (With Cyclophosphamide, Indomethacin, and Zinc) in Patients With Resectable Cancer of the Head and Neck Completed NCT00210470 Phase 2 Cyclophosphamide;Indomethacin;Zinc;Omeprazole
9 Bright Light on Fatigue in Women Being Treated for Breast Cancer: A Pilot Study Completed NCT02658708 Phase 1
10 Transcranial Vibrating System for Improving Outcomes of Vestibular Physical Therapy Unknown status NCT03795168
11 Robot Assisted Supraomohyoid Neck Dissection Via Retroauricular Approach Unknown status NCT01488669
12 Subjective Satisfaction and Audiological Benefit With ADHEAR Audio Processor and ADHEAR Adhesive Adapter in Children Unknown status NCT03327194
13 The Effects of Kinesis-Taping Application on Cognitive Deficit and Motor Ability in Stroke Patients With Visuospatial Neglect: a Randomized Controlled Study Unknown status NCT03263455
14 Can Transcranial Direct Stimulation Enhance the Efficacy of a Rehabilitative Intervention for the Treatment of Freezing of Gait in Parkinson's Disease? A Double Blind Randomized Controlled Study Unknown status NCT02205216
15 Otogenic Cerebral Sinus Vein Thrombosis in Children: Retrospective Case Series and Associated Thrombophilia Completed NCT03864055
16 Trakya University, Faculty of Medicine, Department of Anatomy, Edirne, Turkey Completed NCT02814266
17 Pilot Study Evaluating Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115
18 The Effect of Vestibular Stimulation on Transient Insomnia Induced by a Five-hour Phase Advance of Sleep Time Completed NCT00594022
19 Diagnostic Accuracy of the Vibration Induced Nystagmus Test in Room Light. Completed NCT02626052
20 Mastoid Bone Autograft for Dorsal Nasal Augmentation Completed NCT00545428
21 POSTMARKETING OBSERVATIONAL STUDY OF THE IMPACT OF PREVNAR 13 (PNEUMOCOCCAL 13-VALENT CONJUGATE VACCINE) ON OTITIS MEDIA IN CHILDREN Completed NCT01272999
22 Procalcitonin Level as a Prognostic Marker and Its' Kinetics in Children With Bacterial Infections Completed NCT00714402
23 Effect of Bilateral Scalp Nerve Blocks on Post-operative Pain and Discharge Times in Patients Undergoing Supra-tentorial Craniotomy and General Anaesthesia Completed NCT00972790
24 Audiological Benefit and Improved Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Bonebridge in Experienced Users Completed NCT03766152
25 Prediction of Optimal Laryngeal Mask Airway Cuff Volume From Parameters of Physical Examination of Head and Neck Completed NCT02502422
26 Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry Completed NCT03138382
27 Clinical Performance of a New Implant System for Bone Conduction Hearing Completed NCT03086135
28 Cranial Osteopathic Manipulative Medicine as an Adjunct Treatment for Concussion Completed NCT03225599
29 Feedbacks' Influence on Decision Making Processes Recruiting NCT02816632
30 Effect of Stellate Ganglion Block Combined With Facial Nerve Block on the Treatment of Idiopathic Facial Paralysis Recruiting NCT04800666 Mecobalamin Tablets
31 The Efficacy of Transcranial Alternating Current Stimulation for Treating Post-stroke Depression: a Randomized Controlled Trial Recruiting NCT03903068
32 A Randomised Controlled Trial Comparing the Effectiveness of Surgical and Nonsurgical Treatment for Cervical Radiculopathy Recruiting NCT03674619
33 Acoustic and Vestibular Noise as Possible Non-pharmacological Treatments of ADHD in School Children Recruiting NCT03425669 Active medication
34 tDCS Over the Supplemental Motor Area for the Treatment of Tourette Syndrome Recruiting NCT03401996
35 Effects of Bright Light on Co-occurring Cancer-related Symptoms in Breast Cancer Survivors: A Personalized Intervention Recruiting NCT03304587
36 Passive Electrical Neurofeedback Treatment of mTBI: MEG and Behavioral Outcomes Recruiting NCT03244475
37 Development of a Robotic Minimally Invasive Pathway for Cochlear Implantation Recruiting NCT04048239
38 Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy Active, not recruiting NCT03294421
39 A Prospective, Randomized, Blinded, Placebo-controlled, Single Center, Efficacy Study of a Mastoid Device in Subjects With Ménière's Disease Enrolling by invitation NCT03520322
40 A Prospective, Multicenter, Randomized Controlled Trial of Fastigial Nucleus Stimulation in Patients With Coronary Heart Disease Enrolling by invitation NCT04121715 Standard treatment
41 Hearing Changes After Skull Base and Mastoid Surgery Not yet recruiting NCT04322747
42 A Randomized, Double Blind Sham Controlled Clinical Trial to Evaluate The Efficacy of Vestibular Nerve Stimulation (VeNS), Compared to a Sham Control For Treatment Of Insomnia in Participants With a Diagnosis of PTSD Not yet recruiting NCT04780893
43 A Randomized, Double Blind Sham Controlled Clinical Trial to Evaluate The Efficacy of Vestibular Nerve Stimulation (VeNS), Compared to a Sham Control For Treatment Of Insomnia. Not yet recruiting NCT04452981
44 Determine the Effect of the Fourth Ventricle Compression Technique on Heart Rate, Respiratory Rate, Blood Pressure, Thermal Variation and Skin Conductivity in Healthy Young Adults: a Randomized Clinical Study Not yet recruiting NCT04391777
45 The Effect of Prevention and Treatment of Transcutaneous Electrical Acupoint Stimulation on Postoperative Dizziness in Patients With Hemifacial Spasm Undergoing Microvascular Decompression Surgery: A Randomized Controlled Trial Not yet recruiting NCT04621578
46 Combining Galvanic Vestibular Stimulation and Motor Training in Traumatic Brain Injury Survivors With Attentional Deficits Terminated NCT01749800
47 Double-Blind, Placebo Controlled Trial Of Greater Occipital Nerve Block For The Treatment Of Migraine Status Terminated NCT00329732 0.5% bupivicaine and 2% lidocaine;Saline placebo
48 Is There Hearing Loss After Acute Mastoiditis Withdrawn NCT00502450
49 Combining Physical Therapy With Vestibular Stimulation to Improve Postural Stability in Pusher's Syndrome Withdrawn NCT03831594
50 Surgery Compared to Masking Device for Venous Pulsatile Tinnitus Withdrawn NCT04097041

Search NIH Clinical Center for Mastoiditis

Cochrane evidence based reviews: mastoiditis

Genetic Tests for Mastoiditis

Anatomical Context for Mastoiditis

MalaCards organs/tissues related to Mastoiditis:

40
Bone, Skin, Spinal Cord, Myeloid, Eye, Lymph Node, Breast

Publications for Mastoiditis

Articles related to Mastoiditis:

(show top 50) (show all 1743)
# Title Authors PMID Year
1
Measuring complications of serious pediatric emergencies using ICD-10. 61
33374034 2021
2
Reducing antibiotic prescriptions in children is not associated with higher rate of complications. 61
33145703 2021
3
Evidence of otitis media and mastoiditis in a Medieval Islamic skeleton from Spain and possible implications for ancient surgical treatment of the condition. 61
33232880 2021
4
Gravity and Mastoid Effusion. 61
33115615 2021
5
Impact of the COVID-19 Pandemic on Antibiotic Prescribing for Common Infections in The Netherlands: A Primary Care-Based Observational Cohort Study. 61
33670657 2021
6
Acute mastoiditis complicated by cerebral venous sinus thrombosis in children. 61
33234334 2021
7
Complications in Pediatric Acute Mastoiditis: HCUP KID Analysis. 61
33588620 2021
8
Pediatric Otogenic Cerebral Sinus Vein Thrombosis and Thrombophilia. 61
33595215 2021
9
High-dose steroid and heparin: a novel therapy for cerebral vasculitis associated with presumed group A Streptococcus meningitis. 61
33563670 2021
10
Acute mastoiditis in infants younger than 6 months: is an alternative treatment protocol needed? 61
32500325 2021
11
Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host. 61
33531028 2021
12
Retrospective study of cochlear implantations at a single facility focusing on postoperative complications. 61
33461855 2021
13
Hyperbaric oxygen for intracranial abscess. 61
33648039 2021
14
Managing a Complicated Acute Otomastoiditis at Day Four of Life. 61
33654590 2021
15
Towards improved outcome in children treated surgically for spontaneous intracranial suppuration in South Wales. 61
33428472 2021
16
Temporal Trends and Regionalization of Acute Mastoiditis Management in the United States. 61
33481546 2021
17
Haemophilus influenzae purulent pericarditis in an immunocompetent individual. 61
33552427 2021
18
Impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on acute mastoiditis in children in southern Israel: A 12-year retrospective comparative study (2005-2016). 61
33168224 2021
19
Introducing the High-definition 3D exoscope in ear surgery: preliminary analysis of advantages and limits compared with operative microscope. 61
33386973 2021
20
Tuberculous mastoiditis in a 2-month-old infant presenting with facial nerve palsy. 61
33298491 2020
21
Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing. 61
32918365 2020
22
Image-guided surgical navigation for bone-conduction hearing device implant placement. 61
33068944 2020
23
Our experience on the management of acute mastoiditis in pediatric acute otitis media patients. 61
32927353 2020
24
Medical and surgical characteristics of fusobacterium necrophorum mastoiditis in children. 61
32911237 2020
25
Chronic suppurative otomastoiditis due to nontuberculous mycobacteria: A case series. 61
33152966 2020
26
Facial Nerve Palsy Complicated by Masked Tuberculous Mastoiditis in a Recently Transplanted Patient. 61
32703670 2020
27
The Role of Mastoidectomy in Draining Ventilation Tubes. 61
32189520 2020
28
A common complaint… a rare disease! 61
33172868 2020
29
Minimally invasive and inexpensive percutaneous abscess drainage using an indwelling needle cannula. 61
32911391 2020
30
Management of pediatric head and neck infections in the emergency department. 61
33105074 2020
31
Otogenic Lateral Sinovenous Thrombosis in Children: A Case Series from a Single Centre and Narrative Review. 61
32912560 2020
32
[Prescribing of antibiotics for respiratory tract infections in German outpatient pediatric care : Results of a survey of pediatricians and general practitioners]. 61
32940747 2020
33
Pneumocephalus: A Rare Complication of Mastoiditis and Cerebral Venous Sinus Thrombosis. 61
32983358 2020
34
Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System. 61
30295542 2020
35
A Rare Case of Candida Mastoiditis in an Immunocompetent Patient With Cholesteatoma Ear Disease. 61
32921188 2020
36
The National Landscape of Acute Mastoiditis: Analysis of the Nationwide Readmissions Database. 61
32569137 2020
37
Two probable cases of mastoiditis in a cemetery from the Warring States to Han Dynasty (475 BCE-220 CE) in Qufu, Shandong Province, China. 61
32512538 2020
38
Auricular Protrusion: Not Only Mastoiditis. 61
32086757 2020
39
Pediatric otogenic cerebral venous sinus thrombosis: a case report and a literature review. 61
32883359 2020
40
Bilateral papilledema and abducens nerve palsy following cerebral venous sinus thrombosis due to Gradenigo's syndrome in a pediatric patient. 61
32695930 2020
41
Factors affecting complications and comorbidities in children with cholesteatoma. 61
32413646 2020
42
Acute mastoiditis in infants aged six months or younger. 61
32787992 2020
43
Mastoiditis Masquerade. 61
32841094 2020
44
Mastoiditis, Osteomyelitis, and Septic Arthritis of Temporomandibular Joint. 61
32720812 2020
45
A 10-Month-Old Female With Complicated Mastoiditis Due to Fusobacterium necrophorum: A Case Report and Literature Review. 61
32531061 2020
46
Detection of Coalescent Acute Mastoiditis on MRI in Comparison with CT. 61
32696283 2020
47
Otitis Media and Inborn Errors of Immunity. 61
32654069 2020
48
Post-traumatic preauricular pulsatile swelling in a patient on oral anticoagulation therapy. 61
32646934 2020
49
Unusual Brain MRI Findings in Patients Imaged for Headache: a Case Series. 61
32691182 2020
50
Acute Mastoiditis With Intracranial Complications in a Young Adult With History of Cranioplasty: The Rule in the Post-Antibiotic Era. 61
32864273 2020

Variations for Mastoiditis

Expression for Mastoiditis

Search GEO for disease gene expression data for Mastoiditis.

Pathways for Mastoiditis

Pathways related to Mastoiditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 RUNX1T1 MPO MALT1 CARD11
2
Show member pathways
11.53 SERPINC1 PRTN3 F2
3
Show member pathways
11.26 MTHFR MPO F2 CRP

GO Terms for Mastoiditis

Cellular components related to Mastoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CBM complex GO:0032449 8.62 MALT1 CARD11

Biological processes related to Mastoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell activation GO:0050870 9.16 MALT1 CARD11
2 regulation of blood coagulation GO:0030193 8.96 SERPINC1 F2
3 blood coagulation GO:0007596 8.92 SERPINC1 PRTN3 F2 DOCK8

Molecular functions related to Mastoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 SERPINC1 MPO F2

Sources for Mastoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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