MCID: MTR008
MIFTS: 41

Mature B-Cell Neoplasm

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Mature B-Cell Neoplasm

MalaCards integrated aliases for Mature B-Cell Neoplasm:

Name: Mature B-Cell Neoplasm 12 15 73
Mature B-Cell Lymphocytic Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:706
NCIt 50 C27910
UMLS 73 C1334633

Summaries for Mature B-Cell Neoplasm

MalaCards based summary : Mature B-Cell Neoplasm, also known as mature b-cell lymphocytic neoplasm, is related to burkitt lymphoma and intestinal disease. An important gene associated with Mature B-Cell Neoplasm is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs alemtuzumab and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include b cells, liver and small intestine, and related phenotypes are hematopoietic system and cellular

Related Diseases for Mature B-Cell Neoplasm

Diseases related to Mature B-Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 burkitt lymphoma 30.6 BCL6 CD40 CD40LG MME MYC PVT1
2 intestinal disease 29.6 CD79A SDC1 TLR9 TP53
3 leukemia, chronic lymphocytic 28.7 B2M BCL6 CD19 CD38 CD40 CD40LG
4 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 11.1 BCL6 MYC
5 selective igg deficiency disease 11.0 CD40LG CD79A
6 c1q nephropathy 11.0 CD40LG CD79A
7 meningovascular neurosyphilis 11.0 CD40LG CD79A
8 alpha chain disease 11.0 CD40LG CD79A
9 brill-zinsser disease 11.0 CD40LG CD79A
10 exudative glomerulonephritis 11.0 CD40LG CD79A
11 cork-handlers' disease 11.0 CD40LG CD79A
12 salpingo-oophoritis 11.0 CD40LG CD79A
13 early yaws 11.0 CD40LG CD79A
14 ventilation pneumonitis 11.0 CD40LG CD79A
15 chronic interstitial cystitis 11.0 CD40LG CD79A
16 axillary adenitis 11.0 CD40LG CD79A
17 cryofibrinogenemia 11.0 CD40LG CD79A
18 gallbladder lymphoma 10.9 BCL6 MME
19 precursor t-lymphoblastic lymphoma/leukemia 10.9 CD79A MME
20 trichostrongyloidiasis 10.9 CD40LG CD79A
21 subacute bacterial endocarditis 10.9 CD40LG CD79A
22 heterophyiasis 10.9 CD40LG CD79A
23 immunoglobulin g deficiency 10.9 CD40LG CD79A
24 indolent myeloma 10.9 B2M MYOM2
25 light fixation seizure syndrome 10.9 CD40 CD40LG
26 orbital granuloma 10.9 CD40LG CD79A
27 polyclonal hypergammaglobulinemia 10.9 CD40LG CD79A MYOM2
28 precursor lymphoblastic lymphoma/leukemia 10.9 CD79A MME
29 hyperglobulinemic purpura 10.9 CD40LG CD79A
30 chronic polyneuropathy 10.9 CD40LG CD79A MYOM2
31 gastroduodenitis 10.8 CD40LG CD79A
32 osteosclerotic myeloma 10.8 CD40LG CD79A MYOM2
33 bacterial conjunctivitis 10.8 CD40LG CD79A
34 commensal bacterial infectious disease 10.8 CD40LG CD79A MYOM2
35 heavy chain disease 10.8 CD40LG CD79A
36 ocular toxoplasmosis 10.8 CD40LG CD79A TLR9
37 ophthalmia neonatorum 10.8 CD40LG CD79A
38 coccidiosis 10.8 CD40LG CD79A TLR9
39 sclerosing keratitis 10.8 B2M CD79A
40 immunodeficiency with hyper-igm, type 4 10.8 CD40 CD40LG
41 autoimmune disease of urogenital tract 10.8 CD40LG CD79A TLR9
42 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
43 middle ear disease 10.8 CD40LG CD79A TLR9
44 exanthem 10.8 CD40LG CD79A TLR9
45 opportunistic mycosis 10.8 CD40LG CD79A TLR9
46 parotid disease 10.8 CD40LG CD79A
47 transient hypogammaglobulinemia of infancy 10.7 CD19 CD40LG CD79A
48 parasitic helminthiasis infectious disease 10.7 CD40LG CD79A TLR9
49 parasitic protozoa infectious disease 10.7 CD40LG CD79A TLR9
50 congenital hypogammaglobulinemia 10.7 CD19 CD40LG CD79A

Graphical network of the top 20 diseases related to Mature B-Cell Neoplasm:



Diseases related to Mature B-Cell Neoplasm

Symptoms & Phenotypes for Mature B-Cell Neoplasm

MGI Mouse Phenotypes related to Mature B-Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CD79A CD19 MAEA CD38 B2M CD40
2 cellular MP:0005384 10.26 BCL6 CD79A CD19 CD38 B2M CD40LG
3 immune system MP:0005387 10.22 CD79A CD19 MAEA MME CD38 MYC
4 homeostasis/metabolism MP:0005376 10.21 BCL6 CD79A CD19 MME CD38 B2M
5 endocrine/exocrine gland MP:0005379 10.13 BCL6 CD38 B2M CD40 CD40LG TP53
6 digestive/alimentary MP:0005381 10 CD19 B2M PCSK5 TP53 PTPRC MYC
7 integument MP:0010771 9.86 CD40LG MAEA CD19 MME B2M TP53
8 liver/biliary system MP:0005370 9.76 BCL6 CD79A CD19 MME B2M TP53
9 neoplasm MP:0002006 9.5 CD79A CD19 B2M TP53 PTPRC SDC1
10 renal/urinary system MP:0005367 9.23 CD40LG CD79A CD19 CD40 PCSK5 TP53

Drugs & Therapeutics for Mature B-Cell Neoplasm

Drugs for Mature B-Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 2 216503-57-0
2
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
5
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7 Folic Acid Antagonists Phase 2
8 Cyclosporins Phase 2
9 Dermatologic Agents Phase 2
10 Nucleic Acid Synthesis Inhibitors Phase 2
11 Vitamin B Complex Phase 2
12 Immunosuppressive Agents Phase 2
13 Anti-Infective Agents Phase 2
14 Antifungal Agents Phase 2
15 Antirheumatic Agents Phase 2
16 Antimetabolites Phase 2
17 Antimetabolites, Antineoplastic Phase 2
18 Calcineurin Inhibitors Phase 2
19 Folate Nutraceutical Phase 2
20 Vitamin B9 Nutraceutical Phase 2
21 tyrosine Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyclosporine Plus Methotrexate or Alemtuzumab Terminated NCT02701517 Phase 2 Cyclosporine + METHOTREXATE;Cyclosporine + CAMPATH-1H
2 A Study to Evaluate the Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Patients With Recurrent Mature B-Cell Neoplasms Completed NCT01704963 Phase 1 PCI-32765
3 A Study of HMPL-523 in Patients With Relapsed or Refractory Mature B-cell Neoplasms Recruiting NCT02857998 Phase 1 HMPL-523
4 Liquid Biopsy in Mature B-cell Tumors Recruiting NCT03280394

Search NIH Clinical Center for Mature B-Cell Neoplasm

Genetic Tests for Mature B-Cell Neoplasm

Anatomical Context for Mature B-Cell Neoplasm

MalaCards organs/tissues related to Mature B-Cell Neoplasm:

41
B Cells, Liver, Small Intestine

Publications for Mature B-Cell Neoplasm

Articles related to Mature B-Cell Neoplasm:

(show all 19)
# Title Authors Year
1
Leukemic mature B-cell neoplasm observed during the treatment with romiplostim in patient with thrombocytopenia and liver cirrhosis. ( 29881570 )
2018
2
Role of CD200 in differential diagnosis of mature B-cell neoplasm. ( 28422443 )
2017
3
Global measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms. ( 26679037 )
2016
4
Role of Tyrosine Kinase Inhibitors in Indolent and Other Mature B-Cell Neoplasms. ( 26327780 )
2015
5
Combination of CD160 and CD200 as a useful tool for differential diagnosis between chronic lymphocytic leukemia and other mature B-cell neoplasms. ( 25470765 )
2015
6
Morphologic features of binucleated lymphocytes to assess the diagnosis of persistent B-cell polyclonal lymphocytosis or other mature B-cell neoplasms. ( 24033110 )
2014
7
Azurophilic granular and rod-like inclusion bodies in mature B-cell neoplasm. ( 25293554 )
2014
8
A case of CD5-positive mature B-cell neoplasm with t(10;14)(q24;q11.2) and trisomy 12. ( 25284493 )
2014
9
CD200 has an important role in the differential diagnosis of mature B-cell neoplasms by multiparameter flow cytometry. ( 24243815 )
2014
10
Improved detection rate of cytogenetic abnormalities in chronic lymphocytic leukemia and other mature B-cell neoplasms with use of CpG-oligonucleotide DSP30 and interleukin 2 stimulation. ( 23596118 )
2013
11
CD200 has an important role in the differential diagnosis of mature B-cell neoplasms by multiparameter flow cytometry. ( 24039011 )
2013
12
Frequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms. ( 23589280 )
2013
13
Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytes. ( 22553924 )
2012
14
The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms. ( 22072557 )
2012
15
CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms. ( 22738889 )
2012
16
A paraneoplastic neuromyelitis optica spectrum disorder associated with a mature B-cell neoplasm. ( 21397326 )
2011
17
Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. ( 15542584 )
2005
18
A new translocation t(11;13)(q13;q14) in a mature B-cell neoplasm. ( 12091133 )
2002
19
Application of long-distance polymerase chain reaction to detection of junctional sequences created by chromosomal translocation in mature B-cell neoplasms. ( 8704258 )
1996

Variations for Mature B-Cell Neoplasm

Expression for Mature B-Cell Neoplasm

Search GEO for disease gene expression data for Mature B-Cell Neoplasm.

Pathways for Mature B-Cell Neoplasm

Pathways related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 B2M BCL6 CD19 CD40 CD40LG CD58
2
Show member pathways
13.33 B2M CD19 CD40 CD40LG CD79A PTPRC
3
Show member pathways
12.69 CD19 CD40 CD79A MYC PTPRC TLR9
4 12.32 B2M BCL6 CD19 CD38 CD40LG CD79A
5
Show member pathways
12.28 BCL6 CD19 CD79A MYC PTPRC
6
Show member pathways
12.21 BCL6 CD19 CD40 PTPRC
7 12.15 CD19 CD38 CD40 CD58 MYC TP53
8 12.13 BCL6 CD40 MYC TP53
9 12.03 CD40 CD40LG CD58 PTPRC SDC1
10 11.96 B2M CD19 CD40 CD40LG SH2D1A
11 11.8 CD19 CD38 CD79A MME PTPRC SDC1
12 11.75 CD19 CD38 MME
13 11.59 CD19 CD38 MME PTPRC TLR9
14 11.51 CD40 CD40LG CD58
15 11.45 CD40 CD40LG SDC1 TLR9
16 11.21 CD40 CD40LG MME PTPRC
17 11.18 CD40 CD40LG MYC
18 11 CD19 CD40 CD40LG CD79A PTPRC RFXANK
19 10.95 BCL6 CD19 CD38 CD40 CD40LG MME

GO Terms for Mature B-Cell Neoplasm

Cellular components related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.81 CD19 CD40 CD40LG CD58 CD79A MAEA
2 secretory granule membrane GO:0030667 9.56 CD38 CD58 MME PTPRC
3 cell surface GO:0009986 9.5 B2M CD38 CD40 CD40LG CD58 PTPRC
4 external side of plasma membrane GO:0009897 9.17 B2M CD19 CD40 CD40LG CD79A PTPRC
5 integral component of membrane GO:0016021 10.13 CD19 CD38 CD40 CD40LG CD58 CD79A

Biological processes related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.88 BCL6 CD38 CD40LG MAEA MYC TP53
2 inflammatory response GO:0006954 9.85 BCL6 CD40 CD40LG SDC1 TLR9
3 immune system process GO:0002376 9.85 B2M BCL6 CD40 CD79A SH2D1A TLR9
4 B cell differentiation GO:0030183 9.65 BCL6 CD40LG CD79A
5 regulation of immune response GO:0050776 9.63 B2M BCL6 CD19 CD40 CD40LG SH2D1A
6 B cell receptor signaling pathway GO:0050853 9.56 CD19 CD38 CD79A PTPRC
7 response to molecule of bacterial origin GO:0002237 9.52 B2M TLR9
8 replicative senescence GO:0090399 9.51 MME TP53
9 positive regulation of interleukin-12 production GO:0032735 9.5 CD40 CD40LG TLR9
10 positive regulation of histone deacetylation GO:0031065 9.49 BCL6 TP53
11 regulation of immunoglobulin secretion GO:0051023 9.43 CD40 CD40LG
12 B cell proliferation GO:0042100 9.26 CD40 CD40LG CD79A PTPRC
13 positive regulation of B cell proliferation GO:0030890 9.02 BCL6 CD38 CD40 PTPRC TLR9

Molecular functions related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 B2M BCL6 CD19 CD40 CD40LG CD58

Sources for Mature B-Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....