MCID: MTR008
MIFTS: 37

Mature B-Cell Neoplasm

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Mature B-Cell Neoplasm

MalaCards integrated aliases for Mature B-Cell Neoplasm:

Name: Mature B-Cell Neoplasm 12 15 73
Mature B-Cell Lymphocytic Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:706
NCIt 50 C27910
UMLS 73 C1334633

Summaries for Mature B-Cell Neoplasm

MalaCards based summary : Mature B-Cell Neoplasm, also known as mature b-cell lymphocytic neoplasm, is related to burkitt lymphoma and leukemia, chronic lymphocytic. An important gene associated with Mature B-Cell Neoplasm is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Methotrexate and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and liver, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Related Diseases for Mature B-Cell Neoplasm

Diseases related to Mature B-Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 burkitt lymphoma 31.6 BCL6 CD40 MME MYC PVT1 SH2D1A
2 leukemia, chronic lymphocytic 30.0 B2M BCL6 CD19 CD38 CD40 PTPRC
3 intestinal disease 29.8 BCL6 IL6 MYC SDC1 TLR9
4 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.3 BCL6 MYC
5 encapsulated thymoma 10.3 CD38 MME
6 indolent myeloma 10.3 B2M MYOM2
7 leukemia 10.3
8 central nervous system leukemia 10.3 CD19 MME
9 mononeuritis multiplex 10.2 MAG MYOM2
10 breast lymphoma 10.2 BCL6 CD79A
11 mononeuritis of upper limb and mononeuritis multiplex 10.2 MAG MYOM2
12 primary mediastinal large b-cell lymphoma 10.2 BCL6 MYC
13 lung combined type small cell carcinoma 10.2 MME NCAM1
14 b cell prolymphocytic leukemia 10.2 CD19 CD38 MYC
15 prolymphocytic leukemia 10.2 CD19 CD38 MYC
16 intravascular large b-cell lymphoma 10.2 B2M BCL6 MME
17 glomeruloid hemangioma 10.2 MYOM2 PTPRC
18 chronic polyneuropathy 10.2 MAG MYOM2
19 invasive malignant thymoma 10.2 CD19 CD38 MME
20 subcutaneous panniculitis-like t-cell lymphoma 10.2 MYC NCAM1
21 follicular lymphoma 10.2 BCL6 MME MYC
22 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 BCL6 PTPRC
23 leukemia, chronic lymphocytic 2 10.2
24 lymphocytic leukemia 10.2
25 leukemia, b-cell, chronic 10.2
26 heart lymphoma 10.2 BCL6 MME PTPRC
27 marginal zone b-cell lymphoma 10.2 BCL6 CD79A MME
28 ovarian lymphoma 10.2 MME MYC PTPRC
29 eye lymphoma 10.2 IL6 TLR9
30 testicular lymphoma 10.2 BCL6 MME PTPRC
31 bladder lymphoma 10.2 CD19 CD79A MME
32 congenital hypogammaglobulinemia 10.2 CD19 CD79A
33 primary effusion lymphoma 10.2 BCL6 IL6 MYC
34 streptococcal toxic-shock syndrome 10.2 IL6 MYOM2
35 lymphoblastic lymphoma 10.2 BCL6 MME PTPRC
36 peripheral t-cell lymphoma 10.2 BCL6 MME NCAM1
37 gamma heavy chain disease 10.2 CD19 CD38 PTPRC
38 reticulosarcoma 10.1 B2M BCL6 PTPRC
39 selective igg deficiency disease 10.1 CD19 CD79A NCAM1
40 upper respiratory tract disease 10.1 IL6 MYOM2 TLR9
41 pediatric lymphoma 10.1 CD79A MME NCAM1
42 extramedullary plasmacytoma 10.1 B2M IL6 MYOM2
43 male reproductive system disease 10.1 IL6 MYC TLR9
44 reproductive system disease 10.1 IL6 MYC TLR9
45 polyclonal hypergammaglobulinemia 10.1 IL6 MYOM2
46 anterior scleritis 10.1 B2M CD19 NCAM1
47 pericoronitis 10.1 CD19 NCAM1
48 diffuse large b-cell lymphoma 10.1 BCL6 CD79A MME MYC
49 membranous nephropathy 10.1 B2M CD79A MME
50 plasmablastic lymphoma 10.1 BCL6 CD38 MYC PTPRC

Graphical network of the top 20 diseases related to Mature B-Cell Neoplasm:



Diseases related to Mature B-Cell Neoplasm

Symptoms & Phenotypes for Mature B-Cell Neoplasm

GenomeRNAi Phenotypes related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 BCL6 CD79A MAG MYC NCAM1 PTPRC

MGI Mouse Phenotypes related to Mature B-Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 B2M BCL6 CD19 CD38 CD40 CD79A
2 cellular MP:0005384 10.23 B2M BCL6 CD19 CD38 CD79A IL6
3 homeostasis/metabolism MP:0005376 10.17 B2M BCL6 CD19 CD38 CD40 CD79A
4 immune system MP:0005387 10.16 B2M BCL6 CD19 CD38 CD40 CD79A
5 endocrine/exocrine gland MP:0005379 10.06 B2M BCL6 CD38 CD40 IL6 MYC
6 digestive/alimentary MP:0005381 9.98 B2M CD19 IL6 MYC PCSK5 PTPRC
7 liver/biliary system MP:0005370 9.76 B2M BCL6 CD19 CD79A IL6 MME
8 neoplasm MP:0002006 9.5 B2M CD19 CD79A IL6 MYC PTPRC
9 renal/urinary system MP:0005367 9.17 CD19 CD40 CD79A IL6 PCSK5 PTPRC

Drugs & Therapeutics for Mature B-Cell Neoplasm

Drugs for Mature B-Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
alemtuzumab Approved, Investigational Phase 2 216503-57-0
4
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
5
leucovorin Approved Phase 2 58-05-9 6006 143
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7 Immunosuppressive Agents Phase 2
8 Immunologic Factors Phase 2
9 Dermatologic Agents Phase 2
10 Nucleic Acid Synthesis Inhibitors Phase 2
11 Vitamin B9 Phase 2
12 Antimetabolites, Antineoplastic Phase 2
13 Vitamin B Complex Phase 2
14 Cyclosporins Phase 2
15 Antirheumatic Agents Phase 2
16 Folic Acid Antagonists Phase 2
17 Antifungal Agents Phase 2
18 Antimetabolites Phase 2
19 Folate Phase 2
20 Anti-Infective Agents Phase 2
21 Calcineurin Inhibitors Phase 2
22 tyrosine Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyclosporine Plus Methotrexate or Alemtuzumab Terminated NCT02701517 Phase 2 Cyclosporine + METHOTREXATE;Cyclosporine + CAMPATH-1H
2 A Study to Evaluate the Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Patients With Recurrent Mature B-Cell Neoplasms Completed NCT01704963 Phase 1 PCI-32765
3 A Study of HMPL-523 in Patients With Relapsed or Refractory Mature B-cell Neoplasms Recruiting NCT02857998 Phase 1 HMPL-523
4 Tolerance and Pharmacokinetics of SHR1459 in Patients With Recurrent Replased/Refractory Mature B Cell Neoplasmstumor Recruiting NCT03664297 Phase 1 SHR1459
5 Liquid Biopsy in Mature B-cell Tumors Recruiting NCT03280394

Search NIH Clinical Center for Mature B-Cell Neoplasm

Genetic Tests for Mature B-Cell Neoplasm

Anatomical Context for Mature B-Cell Neoplasm

MalaCards organs/tissues related to Mature B-Cell Neoplasm:

41
B Cells, Bone, Liver, Lung, Heart, T Cells, Bone Marrow

Publications for Mature B-Cell Neoplasm

Articles related to Mature B-Cell Neoplasm:

# Title Authors Year
1
Leukemic mature B-cell neoplasm observed during the treatment with romiplostim in patient with thrombocytopenia and liver cirrhosis. ( 29881570 )
2018
2
Role of CD200 in differential diagnosis of mature B-cell neoplasm. ( 28422443 )
2017
3
Azurophilic granular and rod-like inclusion bodies in mature B-cell neoplasm. ( 25293554 )
2014
4
A case of CD5-positive mature B-cell neoplasm with t(10;14)(q24;q11.2) and trisomy 12. ( 25284493 )
2014
5
A paraneoplastic neuromyelitis optica spectrum disorder associated with a mature B-cell neoplasm. ( 21397326 )
2011
6
A new translocation t(11;13)(q13;q14) in a mature B-cell neoplasm. ( 12091133 )
2002

Variations for Mature B-Cell Neoplasm

Expression for Mature B-Cell Neoplasm

Search GEO for disease gene expression data for Mature B-Cell Neoplasm.

Pathways for Mature B-Cell Neoplasm

GO Terms for Mature B-Cell Neoplasm

Cellular components related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.7 CD19 CD40 MAEA MAG MME PTPRC
2 secretory granule membrane GO:0030667 9.43 CD38 MME PTPRC
3 cell surface GO:0009986 9.43 B2M CD38 CD40 NCAM1 PTPRC SDC1
4 external side of plasma membrane GO:0009897 9.17 B2M CD19 CD40 CD79A NCAM1 PTPRC
5 plasma membrane GO:0005886 10.1 B2M CD19 CD38 CD40 CD79A MAEA

Biological processes related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 BCL6 CD38 IL6 MAEA MYC
2 cytokine-mediated signaling pathway GO:0019221 9.84 BCL6 IL6 MYC SDC1
3 immune system process GO:0002376 9.8 B2M BCL6 CD40 CD79A SH2D1A TLR9
4 inflammatory response GO:0006954 9.77 BCL6 CD40 IL6 SDC1 TLR9
5 defense response to virus GO:0051607 9.71 CD40 IL6 PTPRC TLR9
6 B cell differentiation GO:0030183 9.63 BCL6 CD79A PTPRC
7 negative regulation of neuron projection development GO:0010977 9.61 B2M CD38 MAG
8 erythrocyte development GO:0048821 9.57 BCL6 MAEA
9 positive regulation of glial cell proliferation GO:0060252 9.56 IL6 MYC
10 negative regulation of bone resorption GO:0045779 9.52 CD38 IL6
11 response to molecule of bacterial origin GO:0002237 9.51 B2M TLR9
12 regulation of B cell differentiation GO:0045577 9.49 PTPRC TLR9
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 CD40 PTPRC
14 B cell receptor signaling pathway GO:0050853 9.46 CD19 CD38 CD79A PTPRC
15 B cell proliferation GO:0042100 9.43 CD40 CD79A PTPRC
16 regulation of immune response GO:0050776 9.35 B2M BCL6 CD19 CD40 SH2D1A
17 positive regulation of B cell proliferation GO:0030890 9.02 BCL6 CD38 CD40 PTPRC TLR9

Sources for Mature B-Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....