MCID: MTR008
MIFTS: 36

Mature B-Cell Neoplasm

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Mature B-Cell Neoplasm

MalaCards integrated aliases for Mature B-Cell Neoplasm:

Name: Mature B-Cell Neoplasm 12 15 70
Mature B-Cell Lymphocytic Neoplasm 12
Neoplasm of Mature B-Cells 17

Classifications:



External Ids:

Disease Ontology 12 DOID:706
NCIt 50 C27910
UMLS 70 C1334633

Summaries for Mature B-Cell Neoplasm

MalaCards based summary : Mature B-Cell Neoplasm, also known as mature b-cell lymphocytic neoplasm, is related to burkitt lymphoma and plasma cell neoplasm. An important gene associated with Mature B-Cell Neoplasm is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are MicroRNAs in cancer and IgA-Producing B Cells in the Intestine. The drugs Methotrexate and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone marrow and bone.

Related Diseases for Mature B-Cell Neoplasm

Diseases related to Mature B-Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 burkitt lymphoma 32.5 PVT1 MYC MIR155 IRF4 BCL6
2 plasma cell neoplasm 32.5 SDC1 PVT1 MYOM2 IGHV4-38-2
3 mantle cell lymphoma 31.0 MYC MIR17 MIR155 BCL6
4 follicular lymphoma 31.0 MYC MIR155 IRF4 BCL6
5 lymphoplasmacytic lymphoma 31.0 SDC1 MYOM2 IGHV4-38-2 BCL6
6 marginal zone b-cell lymphoma 30.9 SDC1 MIR142 IRF4 IGHV4-38-2 CCR6 BCL6
7 nodal marginal zone lymphoma 30.8 IRF4 IGHV4-38-2 BCL6
8 b-cell lymphoma 30.6 PVT1 MYC MIR17 MIR155 MIR142 IRF4
9 diffuse large b-cell lymphoma 30.5 SDC1 MYC MIR222 MIR199A1 MIR17 MIR155
10 leukemia, chronic lymphocytic 30.3 SDC1 MYC MIR9-1 MIR23B MIR199A1 MIR17
11 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.6 MYC BCL6
12 lymphoma aids related 10.5 MYC BCL6
13 adult lymphoma 10.5 MYC IRF4 BCL6
14 testicular lymphoma 10.5 IRF4 IGHV4-38-2 BCL6
15 primary cutaneous diffuse large b-cell lymphoma, leg type 10.5 MYC IRF4
16 multicentric castleman disease 10.5 SDC1 IRF4 H2AC18
17 plasmacytoma 10.5 PVT1 MYC IRF4
18 extramedullary plasmacytoma 10.5 SDC1 MYOM2 IRF4
19 tracheal lymphoma 10.5 SDC1 IGHV4-38-2 BCL6
20 non-secretory myeloma 10.5 SDC1 MYOM2 IGHV4-38-2
21 miyoshi muscular dystrophy 1 10.5 MIR222 MIR155 MIR148A
22 paranasal sinus lymphoma 10.5 MYC BCL6
23 chest wall lymphoma 10.5 IGHV4-38-2 CCR6 BCL6
24 richter's syndrome 10.5 MYC MIR17 IRF4 IGHV4-38-2
25 smoldering myeloma 10.5 SDC1 MYOM2 IGHV4-38-2
26 gamma heavy chain disease 10.5 SDC1 IGHV4-38-2
27 autoimmune disease of urogenital tract 10.5 ICOSLG H2AC18 CCR6
28 pediatric lymphoma 10.5 MYC IRF4 IGHV4-38-2 BCL6
29 castleman disease 10.5 SDC1 MYOM2 H2AC18
30 klebsiella pneumonia 10.5 ICOSLG H2AC18 CCR6
31 solitary osseous plasmacytoma 10.5 SDC1 MYOM2
32 in situ carcinoma 10.5 MYC MIR17 MIR142 H2AC18
33 primary mediastinal b-cell lymphoma 10.5 MIR9-1 MIR155 BCL6
34 feingold syndrome 1 10.5 MYC MIR23B MIR17
35 bacterial infectious disease 10.5 MIR155 ICOSLG H2AC18 CCR6
36 cll/sll 10.5 IGHV4-38-2 CCR6 BCL6
37 monoclonal paraproteinemia 10.5 SDC1 IGHV4-38-2
38 mulchandani-bhoj-conlin syndrome 10.5 SDC1 ICOSLG CCR6
39 pleural cancer 10.5 MIR17 MIR142 H2AC18
40 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.5 ICOSLG H2AC18 CCR6
41 gastric lymphoma 10.5 IRF4 IGHV4-38-2 ICOSLG BCL6
42 spinal cord lymphoma 10.5 CCR6 BCL6
43 herpangina 10.5 ICOSLG H2AC18 CCR6
44 ovary adenocarcinoma 10.5 MYC MIR17 H2AC18
45 anemia, autoimmune hemolytic 10.5 IGHV4-38-2 ICOSLG CCR6
46 listeriosis 10.5 ICOSLG H2AC18 CCR6
47 immunodeficiency with hyper-igm, type 2 10.5 IGHV4-38-2 ICOSLG H2AC18 BCL6
48 coccidiosis 10.5 ICOSLG H2AC18 CCR6
49 colonic benign neoplasm 10.5 MYC H2AC18 CCR6
50 anus disease 10.5 ICOSLG H2AC18 CCR6

Graphical network of the top 20 diseases related to Mature B-Cell Neoplasm:



Diseases related to Mature B-Cell Neoplasm

Symptoms & Phenotypes for Mature B-Cell Neoplasm

Drugs & Therapeutics for Mature B-Cell Neoplasm

Drugs for Mature B-Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
3
alemtuzumab Approved, Investigational Phase 2 216503-57-0
4
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
5
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
6
leucovorin Approved Phase 2 58-05-9 6006
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8 Vitamin B9 Phase 2
9 Folic Acid Antagonists Phase 2
10 Antineoplastic Agents, Immunological Phase 2
11 Cyclosporins Phase 2
12 Folate Phase 2
13 Antirheumatic Agents Phase 2
14 Immunosuppressive Agents Phase 2
15 Immunologic Factors Phase 2
16 Dermatologic Agents Phase 2
17 Vitamin B Complex Phase 2
18 Antimetabolites Phase 2
19 Anti-Infective Agents Phase 2
20 Calcineurin Inhibitors Phase 2
21 Antifungal Agents Phase 2
22
Tyrosine Approved, Investigational, Nutraceutical Phase 1 60-18-4 6057

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Trial of Cyclosporine + CAMPATH-1H (ALEMTUZUMAB) vs. Cyclosporine + METHOTREXATE in Patients Diagnosed With Mature B-cell Neoplasms - Chronic Lymphocytic Leukemia and Low-grade Lymphomas - Receiving Allogeneic Hematopoietic Stem Cell Transplantation With Nonmyeloablative Conditioning Regimen Terminated NCT02701517 Phase 2 Cyclosporine + METHOTREXATE;Cyclosporine + CAMPATH-1H
2 A Phase 1 Study of the Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Subjects With Recurrent Mature B-Cell Neoplasms Completed NCT01704963 Phase 1 PCI-32765
3 A Phase I, Open-label, Dose-escalation Study of the Safety and Pharmacokinetics of HMPL-523 in Patients With Relapsed or Refractory Mature B-cell Neoplasms Recruiting NCT02857998 Phase 1 HMPL-523
4 Phase 1 Study to Evaluate the Tolerance and Pharmacokinetics of SHR1459 in Patients With Recurrentreplased/Refractory Mature B Cell Neoplasms Tumor Active, not recruiting NCT03664297 Phase 1 SHR1459
5 Prospective, Observational, Multi-centred, Non-interventional Research Project on Plasma Cell Free DNA Genotyping as a Tool to Inform Mature B-cell Tumor Management Recruiting NCT03280394

Search NIH Clinical Center for Mature B-Cell Neoplasm

Genetic Tests for Mature B-Cell Neoplasm

Anatomical Context for Mature B-Cell Neoplasm

MalaCards organs/tissues related to Mature B-Cell Neoplasm:

40
B Cells, Bone Marrow, Bone, Myeloid, Breast, Skin

Publications for Mature B-Cell Neoplasm

Articles related to Mature B-Cell Neoplasm:

(show top 50) (show all 73)
# Title Authors PMID Year
1
Time-Resolved scRNA-Seq Tracks the Adaptation of a Sensitive MCL Cell Line to Ibrutinib Treatment. 61
33668876 2021
2
Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm. 61
33217360 2020
3
Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms. 61
32788174 2020
4
Hematologist-Level Classification of Mature B-Cell Neoplasm Using Deep Learning on Multiparameter Flow Cytometry Data. 61
32519455 2020
5
Molecular Pathogenesis of Mantle Cell Lymphoma. 61
32861278 2020
6
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes. 61
32584970 2020
7
Treatment of Patients with Relapsed or Refractory Mantle-Cell Lymphoma with Zanubrutinib, a Selective Inhibitor of Bruton's Tyrosine Kinase. 61
32461234 2020
8
Transformation of a low-grade follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma and a lymphoblastic neoplasm expressing Terminal deoxynucleotidyl Transferase: a case report. 61
32713346 2020
9
Pathology and diagnosis of follicular lymphoma and related entities. 61
31791624 2020
10
Lymphoplasmacytic lymphoma associated with diffuse large B-cell lymphoma: Progression or divergent evolution? 61
33180881 2020
11
Quantitative proteomics analysis of differentially expressed proteins in activated B-cell-like diffuse large B-cell lymphoma using quantitative proteomics. 61
31324389 2019
12
Targeting BCL2 with venetoclax is a promising therapeutic strategy for "double-proteinexpression" lymphoma with MYC and BCL2 rearrangements. 61
30523053 2019
13
Heterogeneity among diffuse large B-cell lymphoma: new entities in WHO classification, a first step in personalized therapy. 61
31263826 2019
14
Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report 61
30335234 2018
15
"Triple hit" lymphomas: A retrospective cytology case series of an uncommon high grade B-cell malignancy with C-MYC, BCL-2 and BCL-6 rearrangements. 61
30043475 2018
16
Non-Hodgkin's lymphoma of the oral cavity and maxillofacial region: a pathologist viewpoint. 61
30058399 2018
17
Atypical presentation of hairy cell leukemia: Significance of CD200 on flow cytometry. 61
30197362 2018
18
SOX11, a key oncogenic factor in mantle cell lymphoma. 61
29738333 2018
19
Leukemic mature B-cell neoplasm observed during the treatment with romiplostim in patient with thrombocytopenia and liver cirrhosis. 61
29881570 2018
20
Gastric Carcinoma in a Patient with Chronic Lymphocytic Leukemia: Coincidence or Consequence? 61
29872586 2018
21
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea. 61
28361523 2018
22
A distinctive subgroup of oral EBV+ B-cell neoplasm with polymorphous features is potentially identical to EBV+ mucocutaneous ulcer. 61
28993276 2017
23
Bone lymphoma with multiple negative bone biopsies. 61
28858013 2017
24
Role of CD200 in differential diagnosis of mature B-cell neoplasm. 61
28422443 2017
25
Primary effusion lymphoma: current concepts and management. 61
28399009 2017
26
Genomics of Hairy Cell Leukemia. 61
28297625 2017
27
Biclonal chronic lymphocytic leukemia: A study of two cases and review of literature. 61
28195098 2017
28
The role of SLAMF7 in multiple myeloma: impact on therapy. 61
27376202 2017
29
B-lymphoblastic leukemia in a patient with chronic lymphocytic leukemia: Sequential development of biclonal B-cell neoplasms over a 23-year period in a single individual. 61
27688087 2016
30
The mutational signature of chronic lymphocytic leukemia. 61
27789740 2016
31
Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature. 61
27431583 2016
32
Multiple myeloma and persistence of drug resistance in the age of novel drugs (Review). 61
27175906 2016
33
Lymphoblastic leukemia with surface light chain restriction: A diagnostic dilemma. 61
27510693 2016
34
Subtype distribution of lymphomas in South of Iran, analysis of 1085 cases based on World Health Organization classification. 61
26754635 2016
35
Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: a review of current diagnosis and management. 61
27468353 2016
36
Characteristics of chronic lymphocytic leukemia in Senegal. 61
27110362 2016
37
Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes. 61
25933830 2015
38
A case of CD5-positive mature B-cell neoplasm with t(10;14)(q24;q11.2) and trisomy 12. 61
25284493 2015
39
A Cryptic t(11;14) Translocation in Mantle Cell Lymphoma Highlights the Importance of FISH. 61
26029939 2015
40
Increased bone marrow uptake of 18F-FDG in leukemia patients: preliminary findings. 61
26405641 2015
41
Azurophilic granular and rod-like inclusion bodies in mature B-cell neoplasm. 61
25293554 2014
42
Primary bilateral ovarian Burkitt's lymphoma in a six-year-old child: report of a rare malignancy. 61
25313777 2014
43
De novo hairy cell leukemia with a major BCR/ABL1 rearrangement: a case report with a literature review. 61
24698424 2014
44
Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma. 61
24452203 2014
45
Early diagnosis of intravascular large B-cell lymphoma: clues from routine blood smear morphologic findings. 61
25051078 2014
46
Supernumerary isochromosome 1, idic(1)(p12), leading to tetrasomy 1q in Burkitt lymphoma. 61
24217199 2014
47
Mantle cell lymphoma of blastoid variant with skin lesion and rapid progression: a case report and literature review. 61
23928453 2013
48
Chronic lymphocytic leukemia in Korean patients: frequent atypical immunophenotype and relatively aggressive clinical behavior. 61
23400412 2013
49
Therapy-related myeloid neoplasms in 39 Korean patients: a single institution experience. 61
23483787 2013
50
Novel agents in mantle cell lymphoma. 61
22687455 2012

Variations for Mature B-Cell Neoplasm

Expression for Mature B-Cell Neoplasm

Search GEO for disease gene expression data for Mature B-Cell Neoplasm.

Pathways for Mature B-Cell Neoplasm

Pathways related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 MYC MIR9-1 MIR23B MIR222 MIR199A1 MIR17
2 11.25 ICOSLG CCR6 BCL6
3 11.03 MYC MIR23B MIR222
4 10.71 MIR9-1 MIR222 MIR199A1

GO Terms for Mature B-Cell Neoplasm

Cellular components related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 MIR23B MIR222 MIR20B MIR199A1 MIR17 MIR155
2 extracellular vesicle GO:1903561 9.1 MIR23B MIR222 MIR20B MIR17 MIR148A MIR125A

Biological processes related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 MYC MIR23B MIR20B MIR155 MIR125A
2 cytokine-mediated signaling pathway GO:0019221 9.86 SDC1 MYC IRF4 BCL6
3 miRNA mediated inhibition of translation GO:0035278 9.65 MIR9-1 MIR222 MIR17 MIR155 MIR148A
4 positive regulation of fibroblast proliferation GO:0048146 9.63 MYC MIR17 MIR155
5 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.61 MIR222 MIR155 MIR125A
6 cell growth involved in cardiac muscle cell development GO:0061049 9.58 MIR23B MIR199A1
7 positive regulation of cardiac muscle cell proliferation GO:0060045 9.58 MIR23B MIR222 MIR199A1
8 negative regulation of cell adhesion molecule production GO:0060354 9.57 MIR222 MIR155
9 positive regulation of connective tissue replacement GO:1905205 9.55 MIR199A1 MIR155
10 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.54 MIR17 MIR155
11 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.54 MIR199A1 MIR17 MIR155
12 positive regulation of microglial cell activation GO:1903980 9.52 MIR155 MIR142
13 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.5 MIR222 MIR155 MIR125A
14 negative regulation by host of viral genome replication GO:0044828 9.49 MIR222 MIR155
15 negative regulation of bicellular tight junction assembly GO:1903347 9.48 MIR155 MIR142
16 negative regulation of vascular endothelial growth factor production GO:1904046 9.46 MIR20B MIR199A1 MIR17 MIR125A
17 gene silencing by miRNA GO:0035195 9.32 MIR9-1 MIR23B MIR222 MIR20B MIR199A1 MIR17
18 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.26 MIR199A1 MIR17 MIR155 MIR148A

Molecular functions related to Mature B-Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.43 MIR9-1 MIR23B MIR20B MIR17 MIR142 MIR125A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.32 MIR9-1 MIR23B MIR222 MIR20B MIR199A1 MIR17

Sources for Mature B-Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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