MCID: MTR001
MIFTS: 27

Mature Cataract

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Mature Cataract

MalaCards integrated aliases for Mature Cataract:

Name: Mature Cataract 12 15
Total, Mature Senile Cataract 12
Total or Mature Cataract 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13717
SNOMED-CT 67 193590000
UMLS 70 C0152257

Summaries for Mature Cataract

Disease Ontology : 12 A senile cataract that is characterized by full white or brunescent opacification of the lens of the eye such that the red reflex is obscured. It is a later stage of senile cataracts and is caused by a multifactorial etiology related to aging.

MalaCards based summary : Mature Cataract, also known as total, mature senile cataract, is related to cataract and phacolytic glaucoma. An important gene associated with Mature Cataract is CRYAA (Crystallin Alpha A). The drugs Pharmaceutical Solutions and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and retina, and related phenotype is vision/eye.

Related Diseases for Mature Cataract

Diseases related to Mature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 cataract 29.7 MIP GJA8 CRYGS CRYGD CRYBB2 CRYAA
2 phacolytic glaucoma 11.0
3 disuse amblyopia 10.2 CRYGS CRYAA
4 senile cataract 10.2 CRYGS CRYAA
5 galactosemia ii 10.2 CRYGS CRYAA
6 cataract 1, multiple types 10.1 GJA8 CRYAA
7 nuclear senile cataract 10.1 CRYGS CRYGD
8 intraocular pressure quantitative trait locus 10.1
9 sclerocornea 10.1 GJA8 CRYAA
10 eye accommodation disease 10.1 MIP CRYGS CRYAA
11 posterior polar cataract 10.1 CRYGD CRYAA
12 diabetic cataract 10.1 CRYGS CRYAA AKR1B1
13 macular retinal edema 10.0 CRYAA AKR1B1
14 immature cataract 10.0 MIP GJA8 CRYAA
15 morgagni cataract 10.0 CRYGS CRYAA CPAMD8
16 abruzzo-erickson syndrome 10.0 CRYBB2 CRYAA
17 retinal perforation 10.0 CRYGS CRYBB2 CRYAA
18 anterior segment dysgenesis 9.9 GJA8 CRYAA CPAMD8
19 early-onset lamellar cataract 9.9 MIP CRYGS CRYGD CRYAA
20 presbyopia 9.9 MIP CRYGS CRYGD CRYAA
21 cataract 9, multiple types 9.9 GJA8 CRYBB2 CRYAA
22 cerulean cataract 9.9 MIP CRYGD CRYBB2
23 erythrokeratodermia variabilis et progressiva 1 9.9 GJA8 CRYBB2 CRYAA
24 aniridia 1 9.9 GJA8 CRYBB2 CRYAA
25 anterior segment dysgenesis 1 9.9 GJA8 CPAMD8
26 amblyopia 9.9 GJA8 CRYGS CRYGD CRYAA
27 cataract 30, multiple types 9.9 GJA8 CRYGD CRYBB2
28 congenital nystagmus 9.9 GJA8 CRYAA
29 hypertelorism 9.8
30 noonan syndrome 1 9.8
31 macular degeneration, age-related, 1 9.8
32 cataract 47 9.8
33 ptosis 9.8
34 absolute glaucoma 9.8
35 pseudo-turner syndrome 9.8
36 early-onset sutural cataract 9.8 MIP GJA8 CRYGS CRYBB2
37 cataract 44 9.8 MIP GJA8 CRYBB2 CRYAA
38 nance-horan syndrome 9.7 GJA8 CRYGD CRYBB2 CRYAA
39 cataract microcornea syndrome 9.7 GJA8 CRYGD CRYBB2 CRYAA
40 early-onset nuclear cataract 9.6 MIP GJA8 CRYGD CRYBB2 CRYAA
41 axenfeld-rieger syndrome, type 3 9.6 GJA8 CRYGS CRYBB2 CRYAA CPAMD8
42 lens disease 9.3 MIP GJA8 CRYGS CRYGD CRYBB2 CRYAA

Graphical network of the top 20 diseases related to Mature Cataract:



Diseases related to Mature Cataract

Symptoms & Phenotypes for Mature Cataract

MGI Mouse Phenotypes related to Mature Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.23 AKR1B1 CRYBB2 CRYGD CRYGS GJA8 MIP

Drugs & Therapeutics for Mature Cataract

Drugs for Mature Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3
2 Ophthalmic Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 AQNA-DY001: A Double-Masked, Randomized Study of the Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery Completed NCT00596583 Phase 3 DYME;DYME
2 AQNA-DY002: A Double-Masked, Randomized Study of the Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery Terminated NCT00596492 Phase 3 DYME;DYME

Search NIH Clinical Center for Mature Cataract

Genetic Tests for Mature Cataract

Anatomical Context for Mature Cataract

MalaCards organs/tissues related to Mature Cataract:

40
Eye, Bone Marrow, Retina, Endothelial

Publications for Mature Cataract

Articles related to Mature Cataract:

(show top 50) (show all 257)
# Title Authors PMID Year
1
Posterior Capsule Rupture during Cataract Surgery in Eyes Receiving Intravitreal anti-VEGF Injections. 61
32657614 2021
2
Corneal complication after femtosecond laser-assisted cataract surgery: A case report. 61
33466143 2021
3
Long-time follow-up of asymmetric bilateral diffuse uveal melanocytic proliferation (BDUMP) in a patient with metastasized urothelial carcinoma. 61
33492075 2021
4
Worsening of Retinal Detachment after Cataract Surgery in the Eye with Persistent Fetal Vasculature. 61
33688352 2021
5
"Basket" mattress suture to manage positive vitreous pressure during penetrating keratoplasty. 61
32730748 2020
6
Glueless Simple Limbal Epithelial Transplantation: The Report of the First 2 Cases. 61
32925431 2020
7
Unintentional Staining of the Anterior Vitreous with Trypan Blue During Cataract Surgery. 61
33342199 2020
8
Iris-Claw Lens Implantation in a Patient with Iridoschisis. 61
32857754 2020
9
Ocular Injury Caused by the Sprayed Venom of the Asian Giant Hornet (Vespa mandarinia). 61
32999672 2020
10
Evaluation of biometric parameters in phacomorphic glaucoma and mature cataracts. 61
32264712 2020
11
Unusual Association of Inverse Retinitis Pigmentosa, Scleromalacia, and Neovascular Glaucoma. 61
32367703 2020
12
Simultaneous Cataract, Maculopathy and Optic Atrophy Secondary to High-Voltage Electrical Shock Injury. 61
32076447 2020
13
Early Penetrating Keratoplasty À Chaud May Improve Outcome in Therapy-Resistant Acanthamoeba Keratitis. 61
31317392 2019
14
Central retinal artery occlusion after Descemet membrane reposition by intracameral air: A case report. 61
31432690 2019
15
The Royal College of Ophthalmologists' National Ophthalmology Database Study of cataract surgery. Report 5: Clinical outcome and risk factors for posterior capsule rupture and visual acuity loss following cataract surgery in patients aged 90 years and older. 61
30858564 2019
16
How many challenges we may encounter in anterior megalophthalmos with white cataract: a case report. 61
31146719 2019
17
Supposed endogenous endophthalmitis caused by Serratia marcescens in a cat. 61
31086760 2019
18
Acanthamoeba keratitis - Clinical signs, differential diagnosis and treatment. 61
30899841 2019
19
Bilateral Phacoemulsification in an African Elephant (Loxodonta africana). 61
31380140 2019
20
A Simple, Novel Approach to Capsulorhexis Formation in the Setting of A Mature Cataract and Miotic Pupil. 61
31819361 2019
21
Rapid progression of cataract to mature stage after intravitreal dexamethasone implant injection: a case report. 61
30606142 2019
22
Zepto-rhexis: A new surgical technique of capsulorhexis using precision nano-pulse technology in difficult cataract cases. 61
30038166 2018
23
Comparative Study of Extra Capsular Cataract Extraction (ECCE) and Small Incision Cataract Surgery (SICS): Experience on Cataract Surgery in a Tertiary Center of Army Hospital, Kathmandu. 61
31056560 2018
24
A case of unusual persistent pupillary membrane with total anterior capsular pigmentation. 61
29731474 2018
25
Comparison of ultrasound biomicroscopy and ultrasonographic parameters in eyes with phacomorphic glaucoma and eyes with mature cataract. 61
27624171 2017
26
Incidence of primary peripheral posterior capsular opacification after cataract surgery and posterior capsular opacification in the patients implanted with foldable intraocular lenses. 61
29634704 2017
27
Intravitreal Injection of Bone Marrow Mesenchymal Stem Cells in Patients with Advanced Retinitis Pigmentosa; a Safety Study. 61
28299008 2017
28
Isolated Anterior Lens Capsule Rupture Secondary to Blunt Trauma: Pathophysiology and Treatment. 61
28058159 2016
29
Comparison of the efficacy and safety of femtosecond laser capsulotomy between mature and non-mature cataracts. 61
27101935 2016
30
Ocular ultrasonography focused on the posterior eye segment: what radiologists should know. 61
26910565 2016
31
Preventive and Protective Effect of Nishamalaki in STZ Induced Diabetic Complications in Wistar Rats. 61
27504308 2016
32
Single flash electroretinograms of mature cataractous and fellow eyes. 61
27799729 2016
33
Indications and clinical outcomes of capsular tension ring implantation in phacoemulsification surgery at a tertiary teaching hospital: A review of 4316 cataract surgeries. 61
26597552 2015
34
Novel corneal piggyback technique for consecutive intraocular lens implantation and penetrating keratoplasty surgery. 61
25850705 2015
35
Herpes Simplex Virus Endotheliitis following Descemet's Membrane Endothelial Keratoplasty. 61
26425323 2015
36
Cataract and glaucoma development in juvenile neuronal ceroid lipofuscinosis (batten disease). 61
25365415 2015
37
Fibrous proliferation into anterior segment after acute angle-closure glaucoma. 61
25411932 2015
38
Mead acid supplementation does not rescue rats from cataract and retinal degeneration induced by N-methyl-N-nitrosourea. 61
26023256 2015
39
Central corneal thickness changes following manual small incision cataract surgery. 61
25653497 2015
40
A simple and stable galactosemic cataract model for rats. 61
26550203 2015
41
Anterior segment optical coherence tomography parameters in phacomorphic angle closure and mature cataracts. 61
25335976 2014
42
The prevalence of pseudoexfoliation syndrome and possible systemic associations in patients scheduled for cataract surgery at the Military Medical Academy in Belgrade. 61
25282782 2014
43
Prevalence and risk factors for lens opacities in Nigeria: results of the national blindness and low vision survey. 61
24526441 2014
44
Canine amino acid transport system Xc(-): cDNA sequence, distribution and cystine transport activity in lens epithelial cells. 61
24366150 2014
45
Ameliorative effect of acetyl-L-carnitine and/or nifedipine against selenite-induced cataractogenesis in young albino rats. 61
24530554 2014
46
Ophthalmic viscosurgical device-assisted sutureless-incision cataract surgery for a hard nucleus or mature cataract. 61
24581975 2014
47
Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase. 61
24554718 2014
48
Manual cataract extraction via a subconjunctival limbus oblique incision for mature cataracts. 61
24722270 2014
49
Unilateral cataract and vitreoretinopathy in a case with klippel-trenaunay syndrome. 61
25031878 2014
50
Evaluation of neonatal streptozotocin induced diabetic rat model for the development of cataract. 61
25505935 2014

Variations for Mature Cataract

Expression for Mature Cataract

Search GEO for disease gene expression data for Mature Cataract.

Pathways for Mature Cataract

GO Terms for Mature Cataract

Cellular components related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.62 MIP GJA8

Biological processes related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.56 MIP CRYGD CRYBB2 CRYAA
2 visual perception GO:0007601 9.35 MIP CRYGS CRYGD CRYBB2 CRYAA
3 gap junction-mediated intercellular transport GO:1990349 9.16 MIP GJA8
4 lens development in camera-type eye GO:0002088 9.02 MIP GJA8 CRYGS CRYGD CRYBB2

Molecular functions related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.02 MIP CRYGS CRYGD CRYBB2 CRYAA

Sources for Mature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....