MCID: MTR001
MIFTS: 26

Mature Cataract

Categories: Eye diseases

Aliases & Classifications for Mature Cataract

MalaCards integrated aliases for Mature Cataract:

Name: Mature Cataract 12 15
Total, Mature Senile Cataract 12
Total or Mature Cataract 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13717
SNOMED-CT 68 193590000
UMLS 73 C0152257

Summaries for Mature Cataract

MalaCards based summary : Mature Cataract, also known as total, mature senile cataract, is related to cataract and cataract 24. An important gene associated with Mature Cataract is CRYAA (Crystallin Alpha A). The drugs Theobromine and Catechin have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Decreased influenza A H1N1 (A/WSN/33) virus numbers and Increased gamma-H2AX phosphorylation

Related Diseases for Mature Cataract

Graphical network of the top 20 diseases related to Mature Cataract:



Diseases related to Mature Cataract

Symptoms & Phenotypes for Mature Cataract

GenomeRNAi Phenotypes related to Mature Cataract according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/WSN/33) virus numbers GR00195-A-2 8.96 CRYAA XPNPEP1
2 Increased gamma-H2AX phosphorylation GR00053-A 8.92 CRYAA CRYGB MIP XPNPEP1

MGI Mouse Phenotypes related to Mature Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 CRYBB2 CRYGB CRYGS MIP XPNPEP1

Drugs & Therapeutics for Mature Cataract

Drugs for Mature Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Theobromine Approved, Investigational Phase 4 83-67-0 5429
2
Catechin Nutraceutical Phase 4 154-23-4 9064
3
Epicatechin Investigational, Nutraceutical Phase 4 490-46-0 72276
4 Ophthalmic Solutions Phase 3
5 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract Enrolling by invitation NCT03205202 Phase 4
2 DY001: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery Completed NCT00596583 Phase 3 DYME;DYME
3 DY002: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery Terminated NCT00596492 Phase 3 DYME;DYME
4 A Novel Congenital Cataract Category System Completed NCT02793869

Search NIH Clinical Center for Mature Cataract

Genetic Tests for Mature Cataract

Anatomical Context for Mature Cataract

MalaCards organs/tissues related to Mature Cataract:

41
Eye

Publications for Mature Cataract

Articles related to Mature Cataract:

(show all 22)
# Title Authors Year
1
Comparison of ultrasound biomicroscopy and ultrasonographic parameters in eyes with phacomorphic glaucoma and eyes with mature cataract. ( 27624171 )
2016
2
Ophthalmic viscosurgical device-assisted sutureless-incision cataract surgery for a hard nucleus or mature cataract. ( 24581975 )
2014
3
Visual outcome following extracapsular cataract extraction in mature cataracts with pseudoexfoliation syndrome: A retrospective study. ( 23772121 )
2013
4
MAPK activation in mature cataract associated with Noonan syndrome. ( 24219368 )
2013
5
Manual small incision cataract surgery for mature cataracts. ( 24092459 )
2013
6
Manual cataract extraction via a subconjunctival limbus oblique incision for mature cataracts. ( 24212212 )
2013
7
Establishment of a lens epithelial cell line from a canine mature cataract. ( 22293671 )
2012
8
Spontaneous anterior dislocation of a mature cataract following old trauma. ( 21742748 )
2011
9
Double extra sharp chopper increase efficacy of phacoemulsification for hard mature cataract surgery. ( 20507190 )
2010
10
Mature cataract and lens-induced glaucoma associated with an asymptomatic intralenticular foreign body. ( 17321413 )
2007
11
Safety and efficacy of micro-incisional cataract surgery with bimanual phacoemulsification for white mature cataract. ( 17183197 )
2007
12
Preexisting posterior capsule defect progressing to white mature cataract. ( 17416329 )
2007
13
Bromphenol blue staining in eyes with mature cataract. ( 18053925 )
2007
14
Comparison in effect of different metal ions, pH and reducing agent on the protease activity in human hyper mature and mature cataract. ( 17657864 )
2007
15
Pupillography of relative afferent pupillary defect contralateral to monocular mature cataract. ( 16883363 )
2006
16
Pulsed electron avalanche knife for capsulotomy in congenital and mature cataract. ( 16857491 )
2006
17
Diagnosis of pre-existing posterior capsule defect in traumatic white mature cataract with intact anterior capsule. ( 16096657 )
2006
18
Safety of trypan blue 1% and indocyanine green 0.5% in assisting visualization of anterior capsule during phacoemulsification in mature cataract. ( 15975459 )
2005
19
Management of the mature cataract. ( 12520605 )
2002
20
Anterior polar cataracts in CS rats: a predictor of mature cataract formation. ( 10067970 )
1999
21
Lens reconstruction after mature cataract in SCR rat. ( 10580657 )
1999
22
Use of air in phacoemulsification of mature cataract. ( 9682090 )
1998

Variations for Mature Cataract

Expression for Mature Cataract

Search GEO for disease gene expression data for Mature Cataract.

Pathways for Mature Cataract

GO Terms for Mature Cataract

Biological processes related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.33 CRYAA CRYBB2 MIP
2 lens development in camera-type eye GO:0002088 9.13 CRYGB CRYGS MIP
3 visual perception GO:0007601 8.92 CRYAA CRYBB2 CRYGB MIP

Molecular functions related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.02 CRYAA CRYBB2 CRYGB CRYGS MIP

Sources for Mature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....