MCID: MTR001
MIFTS: 25

Mature Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Mature Cataract

MalaCards integrated aliases for Mature Cataract:

Name: Mature Cataract 12 15
Total, Mature Senile Cataract 12
Total or Mature Cataract 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13717
UMLS 74 C0152257

Summaries for Mature Cataract

MalaCards based summary : Mature Cataract, also known as total, mature senile cataract, is related to cataract and phacolytic glaucoma. An important gene associated with Mature Cataract is CRYGB (Crystallin Gamma B). The drugs Theobromine and Epicatechin have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Mature Cataract

Diseases related to Mature Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 cataract 29.9 CRYBB2 CRYGB CRYGS MIP
2 phacolytic glaucoma 11.1
3 cerulean cataract 9.9 CRYBB2 MIP
4 early-onset nuclear cataract 9.8 CRYBB2 MIP
5 presbyopia 9.8 CRYGS MIP
6 noonan syndrome 1 9.8
7 dermatitis, atopic 9.8
8 myopia 9.8
9 dermatitis 9.8
10 pseudo-turner syndrome 9.8
11 cataract 44 9.8 CRYBB2 CRYGB MIP
12 cataract 25 9.6 CRYBB2 CRYGS MIP
13 cataract 16, multiple types 9.6 CRYGB CRYGS MIP
14 eye accommodation disease 9.6 CRYGS MIP
15 lens disease 9.4 AKR1B1 CRYBB2 CRYGS

Graphical network of the top 20 diseases related to Mature Cataract:



Diseases related to Mature Cataract

Symptoms & Phenotypes for Mature Cataract

GenomeRNAi Phenotypes related to Mature Cataract according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.55 CRYBB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.55 NIN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.55 NIN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.55 CRYBB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.55 CRYBB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.55 CRYBB2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.55 CRYBB2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.55 CRYBB2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.55 CRYBB2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.55 NIN
11 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.55 CRYBB2 NIN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.55 NIN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.55 CRYBB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 CRYBB2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.55 CRYBB2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.55 CRYBB2

MGI Mouse Phenotypes related to Mature Cataract:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 AKR1B1 CRYBB2 CRYGB CRYGS MIP

Drugs & Therapeutics for Mature Cataract

Drugs for Mature Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Theobromine Investigational Phase 4 83-67-0 5429
2
Epicatechin Investigational Phase 4 490-46-0, 35323-91-2 72276
3 Ophthalmic Solutions Phase 3
4 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract Enrolling by invitation NCT03205202 Phase 4
2 DY001: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery Completed NCT00596583 Phase 3 DYME;DYME
3 DY002: Safety and Effectiveness of DYME as an Agent for Selective Staining of the Anterior Capsule During Cataract Surgery Terminated NCT00596492 Phase 3 DYME;DYME
4 Study of the Efficiency and Workflow of Femtosecond Laser Assisted Cataract Surgery in a Spanish Public Hospital Completed NCT03931629 Not Applicable
5 A Novel Congenital Cataract Category System Completed NCT02793869

Search NIH Clinical Center for Mature Cataract

Genetic Tests for Mature Cataract

Anatomical Context for Mature Cataract

MalaCards organs/tissues related to Mature Cataract:

42
Eye

Publications for Mature Cataract

Articles related to Mature Cataract:

(show all 19)
# Title Authors Year
1
Comparison of ultrasound biomicroscopy and ultrasonographic parameters in eyes with phacomorphic glaucoma and eyes with mature cataract. ( 27624171 )
2017
2
Ophthalmic viscosurgical device-assisted sutureless-incision cataract surgery for a hard nucleus or mature cataract. ( 24581975 )
2014
3
MAPK activation in mature cataract associated with Noonan syndrome. ( 24219368 )
2013
4
Establishment of a lens epithelial cell line from a canine mature cataract. ( 22293671 )
2012
5
Spontaneous anterior dislocation of a mature cataract following old trauma. ( 21742748 )
2011
6
Double extra sharp chopper increase efficacy of phacoemulsification for hard mature cataract surgery. ( 20507190 )
2010
7
Safety and efficacy of micro-incisional cataract surgery with bimanual phacoemulsification for white mature cataract. ( 17183197 )
2007
8
Mature cataract and lens-induced glaucoma associated with an asymptomatic intralenticular foreign body. ( 17321413 )
2007
9
Preexisting posterior capsule defect progressing to white mature cataract. ( 17416329 )
2007
10
Comparison in effect of different metal ions, pH and reducing agent on the protease activity in human hyper mature and mature cataract. ( 17657864 )
2007
11
Bromphenol blue staining in eyes with mature cataract. ( 18053925 )
2007
12
Diagnosis of pre-existing posterior capsule defect in traumatic white mature cataract with intact anterior capsule. ( 16096657 )
2006
13
Pulsed electron avalanche knife for capsulotomy in congenital and mature cataract. ( 16857491 )
2006
14
Pupillography of relative afferent pupillary defect contralateral to monocular mature cataract. ( 16883363 )
2006
15
Safety of trypan blue 1% and indocyanine green 0.5% in assisting visualization of anterior capsule during phacoemulsification in mature cataract. ( 15975459 )
2005
16
Management of the mature cataract. ( 12520605 )
2002
17
Anterior polar cataracts in CS rats: a predictor of mature cataract formation. ( 10067970 )
1999
18
Lens reconstruction after mature cataract in SCR rat. ( 10580657 )
1999
19
Use of air in phacoemulsification of mature cataract. ( 9682090 )
1998

Variations for Mature Cataract

Expression for Mature Cataract

Search GEO for disease gene expression data for Mature Cataract.

Pathways for Mature Cataract

GO Terms for Mature Cataract

Biological processes related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.13 CRYBB2 CRYGB MIP
2 lens development in camera-type eye GO:0002088 8.62 CRYGB CRYGS

Molecular functions related to Mature Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 CRYBB2 CRYGB CRYGS MIP

Sources for Mature Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....