MCID: MTR010
MIFTS: 40

Mature Teratoma

Categories: Cancer diseases

Aliases & Classifications for Mature Teratoma

MalaCards integrated aliases for Mature Teratoma:

Name: Mature Teratoma 12 15 70
Benign Teratoma 70
Dermoid Cyst 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5566
NCIt 50 C9015
SNOMED-CT 67 55818009
UMLS 70 C0011649 C1368910 C1879828

Summaries for Mature Teratoma

Disease Ontology : 12 A teratoma that is composed exclusively of mature tissues derived from two or three germ layers.

MalaCards based summary : Mature Teratoma, also known as benign teratoma, is related to mature teratoma of the ovary and ovarian solid teratoma. An important gene associated with Mature Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Developmental Biology. The drugs Cisplatin and Palbociclib have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mature Teratoma

Diseases related to Mature Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 648)
# Related Disease Score Top Affiliating Genes
1 mature teratoma of the ovary 32.3 ENO2 AFP
2 ovarian solid teratoma 32.0 TNFRSF8 AFP
3 nonseminomatous germ cell tumor 30.9 ERBB2 BRAF AFP
4 mixed germ cell tumor 30.9 KIT AFP
5 testicular cancer 30.5 TP53 KRAS ENO2 AFP
6 ovarian mixed germ cell neoplasm 30.3 KIT CEACAM5 AFP
7 adult teratoma 30.3 TP53 CEACAM5 AFP
8 in situ carcinoma 30.3 TP53 H2AC18 ERBB2
9 ovarian carcinosarcoma 30.2 TP53 H2AC18 ERBB2
10 ovarian germ cell teratoma 30.2 SYP MIR302C KRT7 AFP
11 differentiated thyroid carcinoma 30.2 TP53 KRAS BRAF
12 lymphangioma 30.1 TP53 KRAS H2AC18 CEACAM5
13 squamous cell carcinoma 30.0 TP53 KRT7 ERBB2 CEACAM5 BRAF
14 testicular germ cell tumor 30.0 MIR371A KIT BRAF AFP
15 teratoma 30.0 TP53 SYP POU5F1 KRT7 KRAS KIT
16 central neurocytoma 30.0 SYP PCNA ENO2
17 germinoma 29.9 SALL4 POU5F1 MIR371A MIR302A KIT AFP
18 pineoblastoma 29.8 SYP POU5F1 CEACAM5 AFP
19 pineal gland cancer 29.8 SYP ENO2 AFP
20 obstructive hydrocephalus 29.8 SYP ENO2 AFP
21 cystic teratoma 29.8 TP53 SYP KRT7 KRAS KIT ENO2
22 pineocytoma 29.8 SYP ENO2
23 angiosarcoma 29.8 TP53 KRT7 KRAS KIT
24 appendix adenocarcinoma 29.8 SYP KRT7 KRAS
25 embryonal carcinoma 29.8 TNFRSF8 POU5F1 NANOG MIR302A KIT AFP
26 glomus tumor 29.8 TP53 SYP ENO2
27 papillary carcinoma 29.7 SYP KRT7 ERBB2 BRAF
28 neurofibroma 29.7 TP53 SYP KIT ERBB2
29 gliosarcoma 29.6 TP53 H2AC18 ERBB2 ENO2 BRAF
30 oligodendroglioma 29.6 TP53 SYP PCNA ENO2
31 intestinal obstruction 29.6 KRT7 KIT CEACAM5
32 horseshoe kidney 29.5 SYP KRT7 ENO2
33 cystadenocarcinoma 29.5 TP53 NANOG KRT7 ERBB2 CEACAM5 BRAF
34 pineal region teratoma 29.5 SYP KIT ENO2 AFP
35 benign teratoma 29.4 TP53 SYP SALL4 KRT7 ENO2 CEACAM5
36 cystadenoma 29.4 SYP KRT7 CEACAM5 AFP
37 orbital cellulitis 29.4 TNFRSF8 KRT7
38 adenocarcinoma 29.4 TP53 KRT7 KRAS KIT ERBB2 CEACAM5
39 mucinous adenocarcinoma 29.3 TP53 KRT7 KRAS KIT ERBB2 CEACAM5
40 basal cell carcinoma 29.3 TP53 SYP KRT7 KIT CEACAM5
41 carcinosarcoma 29.3 TP53 KRT7 KRAS KIT ERBB2
42 seminoma 29.2 TP53 TNFRSF8 POU5F1 NANOG KIT ENO2
43 salivary gland carcinoma 29.2 TP53 KRT7 KIT H2AC18 ERBB2
44 endodermal sinus tumor 29.2 TNFRSF8 SALL4 MIR371A MIR302C MIR302A KRT7
45 spermatocytoma 29.1 SALL4 POU5F1 NANOG MIR371A KIT AFP
46 neuroblastoma 29.0 TP53 SYP POU5F1 KIT ERBB2 ENO2
47 mixed germ cell cancer 29.0 TNFRSF8 SALL4 MIR371A MIR302A KIT AFP
48 adenosquamous carcinoma 28.9 TP53 SYP KRT7 KRAS KIT CEACAM5
49 neuroendocrine carcinoma 28.8 SYP KRT7 KIT ENO2 CEACAM5
50 renal cell carcinoma, nonpapillary 28.7 TP53 KRT7 KIT H2AC18 ENO2 BRAF

Graphical network of the top 20 diseases related to Mature Teratoma:



Diseases related to Mature Teratoma

Symptoms & Phenotypes for Mature Teratoma

GenomeRNAi Phenotypes related to Mature Teratoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP

MGI Mouse Phenotypes related to Mature Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.28 AFP BRAF ERBB2 KIT KRAS PCNA

Drugs & Therapeutics for Mature Teratoma

Drugs for Mature Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 5330286 11431660
3 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
4 Protein Kinase Inhibitors Phase 2
5 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-Port Compared With Conventional Laparoscopic Cystectomy for Ovarian Dermoid Cysts Completed NCT02009228 Phase 3
2 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
3 A Non-randomized Controlled Clinical Trial of Corneal Epithelial Autograft for Limbal Dermoid Unknown status NCT03217461
4 Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries: Prospective Randomized Trials Unknown status NCT02580500
5 Mesial Incision for Laparoscopic Dermoid Cystectomy: a New Safe and Fertility-sparing Technique Completed NCT01590030
6 Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence Not yet recruiting NCT03823833

Search NIH Clinical Center for Mature Teratoma

Genetic Tests for Mature Teratoma

Anatomical Context for Mature Teratoma

MalaCards organs/tissues related to Mature Teratoma:

40
Ovary, Testis, Tongue, Lymph Node, Pineal, Pancreas, Spinal Cord

Publications for Mature Teratoma

Articles related to Mature Teratoma:

(show top 50) (show all 3921)
# Title Authors PMID Year
1
Dermoid cyst in the subcutaneous tissues of the back: A rare case with multimodal imaging and pathologic correlation. 61
33732406 2021
2
Incidental Detection of Radiotracer Uptake in Intracranial Dermoid Cyst on 18F-Prostate-Specific Membrane Antigen PET/CT During Staging for Prostate Carcinoma. 61
33323739 2021
3
Laparoscopic Management of an Ovarian Dermoid Cyst Containing a Mandibular Structure with Teeth: A Novel Surgical Approach. 61
33045371 2021
4
Ultrasound evaluation of persistent cervical lymph nodes in young children. 61
33551150 2021
5
[Pediatric ovarian tumors: a 10-year review in a pediatric service]. 61
33749206 2021
6
Bilobed Dermoid Cyst in Unique Location. 61
32282645 2021
7
A Dermoid Cyst Presenting as a Hypoechoic Pancreatic Mass. 61
32453050 2021
8
Concomitant Congenital Intraoral Dermoid Cyst and Heterotopic Gastrointestinal Cyst. 61
32285307 2021
9
Vaginal Dermoid Cyst. 61
33713684 2021
10
Spheno-orbital Lesions-A Major Review of Nonmeningioma Causes. 61
33782321 2021
11
A dermoid cyst misdiagnosed as a lipoma due to atypical magnetic resonance images: a case report. 61
33648548 2021
12
A Case Series of Intramuscular Orbital Choristomatous Cysts. 61
32675726 2021
13
Bronchus-like Structures in Ovarian Teratomas: Report of a Series of a Previously Unreported Phenomenon With Potential For Misdiagnosis. 61
33770061 2021
14
An unusual case of struma ovarii. 61
33682680 2021
15
Blood testis barrier revisited-Analysis of post-chemotherapy germ cell tumor orchidectomy and retroperitoneal lymph node dissection specimens. 61
33428791 2021
16
Mucinous Epithelium in Endometrial Curetting Leading to Diagnostic Conundrum: A Case Report. 61
33782342 2021
17
CT and MRI characteristics of ovarian mature teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis. 61
33785312 2021
18
Growing teratoma syndrome in mixed hepatoblastoma with teratoid features. 61
33731392 2021
19
Rare case of a patient with symptomatic Meckel's diverticulum enteroliths. 61
33608344 2021
20
Pilonidal sinus of the cheek: an extremely rare clinical entity-case report and brief review of the literature. 61
33563340 2021
21
Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma. 61
32873866 2021
22
New surgical paradigm for open neural tube defects. 61
32821986 2021
23
Ovarian and non-ovarian teratomas: a wide spectrum of features. 61
32875471 2021
24
Unilateral akathisia and choreoathetosis as an unusual presentation of a frontal lobe dermoid cyst. 61
32098514 2021
25
Primary Ovarian Melanoma Arising From a Mature Teratoma With Melanoma In Situ Present in the Ciliated Columnar and Squamous Epithelium in a Patient With Synchronous Skin Basal Cell Carcinoma. 61
33560745 2021
26
Incidental cerebellar dermoid cyst mimicking low grade glioma in a teenager. 61
33619147 2021
27
A Common Tumor with an Unusual Finding: Mature Cystic Teratoma Containing a Ganglioneuroma. 61
32828965 2021
28
Primary Mature Teratoma of the Rectum: A Case Report. 61
33518697 2021
29
Ruptured mediastinal mature teratoma causing severe mediastinitis: report of a surgically resected case and a literature review. 61
33591407 2021
30
Ovarian mixed germ-cell tumor comprising mature teratoma and embryonal carcinoma in a four-toed hedgehog (Atelerix albiventris). 61
33536394 2021
31
Antenatal Diagnosis of Retroperitoneal Cystic Mass: Fetiform Teratoma or Fetus in Fetu? A Case Report. 61
33568621 2021
32
Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma. 61
33530815 2021
33
So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma? 61
32818237 2021
34
Thymic lipofibroadenoma accompanied with largish calcifications. 61
32886276 2021
35
[Retrorectal teratoma (dermoid cyst) of an adult - Diagnosis and treatment based on an example of a case report]. 61
33465806 2021
36
Retroperitoneal dermoid cyst in a young boy. 61
33777304 2021
37
Pictorial Review of Mediastinal Masses with an Emphasis on Magnetic Resonance Imaging. 61
32783412 2021
38
Growth of Intramedullary Spinal Cord Dermoid Cyst from a Congenital Thoracic Dermal Sinus Tract after Negative Screening Ultrasound Imaging. 61
33503616 2021
39
Ovarian teratoma with pituitary tissue: A case report. 61
33364180 2021
40
Cecal dermoid masquerading dermoid cyst of ovary: a case report and review of the literature. 61
33514417 2021
41
Diastematomyelia type I associated with intramedullary lipoma and dermoid cyst. 61
33403491 2021
42
Role of prenatal imaging in the diagnosis and management of fetal facio-cervical masses. 61
33446872 2021
43
The congenital sternoclavicular sinus: a single-institution retrospective study of 88 patients. 61
33485384 2021
44
Surgical Management of Adnexal Masses in Pregnancy: A Systematic Review and Meta-analysis. 61
33515746 2021
45
Malignant sacrococcygeal germ cell tumors in children in Taiwan: A retrospective single-center case series. 61
33530223 2021
46
Mature Teratoma in the Right Ventricle. 61
33482158 2021
47
Endonasal Transpterygoid Surgery for Adult Mature Teratoma in the Sphenoid Bone. 61
32833816 2021
48
Surgical Management of Cervical Non-seminomatous Germ Cell Tumor Metastases. 61
33421136 2021
49
Successful resection of giant mediastinal tumor with growing teratoma syndrome by bilateral transmanubrial approach, clamshell and median sternotomy. 61
33515399 2021
50
Testis-Preserving Tumor Enucleation Is Applicable in Children with Immature Testicular Teratoma. 61
33176305 2021

Variations for Mature Teratoma

Expression for Mature Teratoma

Search GEO for disease gene expression data for Mature Teratoma.

Pathways for Mature Teratoma

Pathways related to Mature Teratoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 TP53 TNFRSF8 NANOG KRAS KIT ERBB2
2
Show member pathways
13.12 SALL4 POU5F1 NANOG KRT7 KRAS KIT
3 12.68 TP53 KRAS KIT ERBB2 BRAF
4 12.56 TP53 KRAS KIT ERBB2 BRAF
5
Show member pathways
12.55 TP53 PCNA KRAS KIT ERBB2 BRAF
6
Show member pathways
12.54 TP53 KRAS KIT ERBB2 BRAF
7 11.88 PCNA KRAS ERBB2 BRAF
8 11.87 TP53 NANOG KRAS ERBB2 BRAF
9
Show member pathways
11.64 KRAS KIT BRAF
10 11.61 TP53 KRAS BRAF
11 11.41 POU5F1 NANOG MIR302A
12 11.33 POU5F1 NANOG KIT
13
Show member pathways
11.27 SALL4 POU5F1 NANOG
14 11.12 TP53 KRAS ERBB2 BRAF
15 10.77 TP53 KRAS KIT ERBB2
16
Show member pathways
10.52 POU5F1 NANOG

GO Terms for Mature Teratoma

Biological processes related to Mature Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.73 TP53 SALL4 PCNA ERBB2
2 positive regulation of MAP kinase activity GO:0043406 9.58 KRAS KIT ERBB2
3 stem cell population maintenance GO:0019827 9.5 SALL4 NANOG KIT
4 positive regulation of gene expression GO:0010628 9.43 TP53 POU5F1 KRAS KIT ERBB2 BRAF
5 myeloid progenitor cell differentiation GO:0002318 9.37 KIT BRAF
6 visual learning GO:0008542 9.33 KRAS KIT BRAF
7 endodermal cell fate specification GO:0001714 9.26 POU5F1 NANOG
8 somatic stem cell population maintenance GO:0035019 9.02 SALL4 POU5F1 NANOG KIT BRAF

Sources for Mature Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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