Mature Teratoma of the Ovary disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MTR011 MIFTS: 25	Mature Teratoma of the Ovary Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

Sources

Aliases & Classifications for Mature Teratoma of the Ovary

MalaCards integrated aliases for Mature Teratoma of the Ovary:

Name: Mature Teratoma of the Ovary ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6231

NCIt ⁵⁰ C8112

UMLS ⁷¹ C1334637

Sources

Summaries for Mature Teratoma of the Ovary

Disease Ontology : ¹² An ovarian biphasic or triphasic teratoma that is composed exclusively of mature tissues derived from two or three germ layers (ectoderm, mesoderm and endoderm).

MalaCards based summary : Mature Teratoma of the Ovary is related to mature teratoma and childhood mature teratoma of the ovary. An important gene associated with Mature Teratoma of the Ovary is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cell adhesion molecules. Affiliated tissues include ovary and thyroid.

Sources

Related Diseases for Mature Teratoma of the Ovary

Diseases related to Mature Teratoma of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Related Disease	Score	Top Affiliating Genes
1	mature teratoma	31.1	ENO2 AFP
2	childhood mature teratoma of the ovary	11.7
3	ovarian fetiform teratoma	11.3
4	ovarian solid teratoma	11.3
5	teratoma	10.7
6	adult type testicular granulosa cell tumor	10.2	MLANA AFP
7	hepatic angiomyolipoma	10.2	MLANA AFP
8	sex cord-gonadal stromal tumor	10.2	MLANA AFP
9	immature teratoma of ovary	10.1	TG AFP
10	middle ear adenocarcinoma	10.1	TG AFP
11	middle ear carcinoma	10.1	TG AFP
12	mycobacterium tuberculosis 1	10.1
13	abdominal tuberculosis	10.1
14	endometriosis of ovary	10.1
15	squamous cell carcinoma	10.1
16	glomus tumor	10.1
17	ovarian brenner tumor	10.1
18	cystic teratoma	10.1
19	endometriosis	10.1
20	sebaceous adenocarcinoma	10.1
21	gliomatosis peritonei	10.1
22	penis sarcoma	10.1	MLANA ENO2
23	ovarian benign neoplasm	10.1	TG AFP
24	meningeal melanocytoma	10.1	MLANA ENO2
25	ovarian germ cell cancer	10.1	TG AFP
26	central nervous system melanocytic neoplasm	10.1	MLANA ENO2
27	sensory organ benign neoplasm	10.1	MLANA ENO2
28	pineal region teratoma	10.1	ENO2 AFP
29	malignant granular cell myoblastoma	10.1	MLANA ENO2
30	paratesticular lipoma	10.1	ENO2 AFP
31	lipoma of spermatic cord	10.1	ENO2 AFP
32	olfactory nerve neoplasm	10.1	MLANA ENO2
33	cranial nerve malignant neoplasm	10.1	MLANA ENO2
34	liver leiomyosarcoma	10.1	ENO2 AFP
35	cranial nerve neoplasm	10.0	MLANA ENO2
36	mediastinal cancer	10.0	ENO2 AFP
37	subleukemic leukemia	10.0	MLANA ENO2
38	pineal gland cancer	10.0	ENO2 AFP
39	adrenal cortex disease	10.0	TG MLANA
40	malignant teratoma	10.0	ENO2 AFP
41	obstructive hydrocephalus	10.0	ENO2 AFP
42	granular cell tumor	10.0	MLANA ENO2
43	sertoli-leydig cell tumor	10.0	ENO2 AFP
44	mixed cell type cancer	10.0	ENO2 AFP
45	sertoli cell tumor	10.0	ENO2 AFP
46	connective tissue benign neoplasm	10.0	MLANA ENO2
47	tubular adenocarcinoma	10.0	ENO2 AFP
48	atypical follicular adenoma	10.0	TG ENO2
49	ovarian germ cell teratoma	10.0	TG SIGLEC5 AFP
50	carotid body cancer	10.0	TG ENO2

Graphical network of the top 20 diseases related to Mature Teratoma of the Ovary:

Sources

Symptoms & Phenotypes for Mature Teratoma of the Ovary

Sources

Drugs & Therapeutics for Mature Teratoma of the Ovary

Search Clinical Trials , NIH Clinical Center for Mature Teratoma of the Ovary

Sources

Genetic Tests for Mature Teratoma of the Ovary

Sources

Anatomical Context for Mature Teratoma of the Ovary

MalaCards organs/tissues related to Mature Teratoma of the Ovary:

⁴⁰

Ovary, Thyroid

Sources

Publications for Mature Teratoma of the Ovary

Articles related to Mature Teratoma of the Ovary:

(show all 31)

#	Title	Authors	PMID	Year
1	Clinical approach to the diagnosis and successful management of anti-NMDA receptor encephalitis when antibody testing is not possible. ⁶¹	Ramlackhansingh AF...King DJ	31604715	2019
2	Sebaceous carcinoma in a mature teratoma of the ovary. ⁶¹	de Lima RB...Kami RM	30775330	2018
3	Squamous Cell Carcinoma Arising in Mature Teratoma of the Ovary Masquerading as Abdominal Tuberculosis. ⁶¹	Indulkar ST...Khade AL	29628730	2018
4	Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report. ⁶¹	Nemejcova K...Tuckova I	28248120	2017
5	Rare Skin Adnexal and Melanocytic Tumors Arising in Ovarian Mature Cystic Teratomas: A Report of 3 Cases and Review of the Literature. ⁶¹	Moulla AA...El-Bahrawy M	26974995	2016
6	Clinical and histological profile of surgically managed benign adnexal masses. ⁶¹	Gowri V...Machado L	24936279	2014
7	A rare case of follicular thyroid carcinoma in ovarian struma. ⁶¹	Prasad P...Soomro I	18939380	2008
8	[Abdominal colic caused by mature cystic teratoma of the ovary]. ⁶¹	Maurer T...Hartung R	17068669	2007
9	[Mature cystic teratoma of the ovary with a small ganglioneuroma]. ⁶¹	Marucci G...Collina G	16789685	2006
10	Mature ovarian teratoma with gliomatosis peritonei--a case report. ⁶¹	Das CJ...Mannan R	16276020	2005
11	An ovarian mucinous adenocarcinoma arising from mature cystic teratoma associated with respiratory type tissue: a case report. ⁶¹	Cobellis L...Petraglia F	15656343	2004
12	A solid mature teratoma of a feline ovary. ⁶¹	Sato T...Yamaguchi T	14623205	2003
13	Gliomatosis peritonei with mature teratoma of the ovary. ⁶¹	Gabrys M...Ekonjo GB	12722472	2002
14	[Diagnostic image (24). Ovary with a mature teratoma (so-called dermoid cyst)]. ⁶¹	Blaauwgeers JL...Hart W	11236373	2001
15	Excision of mature teratoma using culdotomy, with and without laparoscopy: a prospective randomised trial. ⁶¹	Wang PH...Yuan CC	11213011	2001
16	Struma ovarii mimicking a benign multicystic ovarian tumor: MR imaging in one case. ⁶¹	Yen CH...Chang CY	11392106	2000
17	Glomus tumor arising in a mature teratoma of the ovary: report of a case simulating a metastasis from cervical squamous carcinoma. ⁶¹	Silver SA...Tavassoli FA	10975942	2000
18	Disseminated carcinomatosis after laparoscopic surgery for presumably benign ruptured ovarian teratoma. ⁶¹	Wang PH...Yuan CC	10733031	2000
19	Metastasis of a breast carcinoma in a mature teratoma of the ovary. ⁶¹	Kirova YM...Le Bourgeois JP	10410892	1999
20	Mature teratoma of the ovary with predominant benign anlage component. Report of a case. ⁶¹	Makris N...Michalas S	10410893	1999
21	[Autoimmune hemolytic anemia associated with a mature ovarian teratoma]. ⁶¹	Glorieux I...Robert A	10223111	1998
22	Goblet cell carcinoid arising in a mature teratoma of the mediastinum. ⁶¹	Lancaster KJ...McCabe KM	8990147	1997
23	Endoscopic surgery for mature teratoma of the ovary. ⁶¹	Ulrich U...Sasse V	8703147	1996
24	Solid mature teratoma of the ovary: appearances at MR imaging. ⁶¹	Kawakami S...Konishi J	8025887	1994
25	Complications and bilaterality of mature ovarian teratomas (clinicopathological evaluation of 286 cases). ⁶¹	Ayhan A...Ayhan A	1872783	1991
26	[Mature teratoma of the ovary--a clinicopathologic study of 214 teratomas of the ovary]. ⁶¹	Chang JC...Chen HF	3454709	1986
27	[Peritoneal gliomatosis associated with a mature teratoma of the ovary]. ⁶¹	Vital A...Vital C	4015762	1985
28	[Mature teratoma of the ovary with carcinoma]. ⁶¹	Carinelli SG...Belloni C	6732101	1984
29	[Mature teratoma of the ovary. Clinical and anatomo-pathological considerations on 239 cases]. ⁶¹	Carinelli SG...Remotti G	6760772	1982
30	[Carcinoid in a mature teratoma of the ovary]. ⁶¹	Kovalenko VL...Daitkhe AI	7224036	1981
31	Covert bilaterality of mature ovarian teratomas. ⁶¹	Doss N...Nalick RH	927754	1977

Sources

Genes for Mature Teratoma of the Ovary

Genes related to Mature Teratoma of the Ovary (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	8.5	DISEASES inferred ¹⁵ ¹⁵
2	MLANA	Melan-A	Protein Coding	5.85	DISEASES inferred ¹⁵
3	AFP	Alpha Fetoprotein	Protein Coding	5.41	DISEASES inferred ¹⁵
4	SLAMF6	SLAM Family Member 6	Protein Coding	5.28	DISEASES inferred ¹⁵
5	CD226	CD226 Molecule	Protein Coding	5.14	DISEASES inferred ¹⁵
6	UPK2	Uroplakin 2	Protein Coding	5.05	DISEASES inferred ¹⁵
7	NECTIN2	Nectin Cell Adhesion Molecule 2	Protein Coding	5.01	DISEASES inferred ¹⁵
8	ENO2	Enolase 2	Protein Coding	4.81	DISEASES inferred ¹⁵
9	PVR	PVR Cell Adhesion Molecule	Protein Coding	4.81	DISEASES inferred ¹⁵
10	TG	Thyroglobulin	Protein Coding	4.77	DISEASES inferred ¹⁵

Sources

Variations for Mature Teratoma of the Ovary

Sources

Expression for Mature Teratoma of the Ovary

Search GEO for disease gene expression data for Mature Teratoma of the Ovary.

Sources

Pathways for Mature Teratoma of the Ovary

Pathways related to Mature Teratoma of the Ovary according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	12.83	SLAMF6 SIGLEC5 PVR NECTIN2 CD226
2	Cell adhesion molecules ³⁶	11.31	PVR NECTIN2 CD226
3	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁵	11.15	SLAMF6 SIGLEC5 PVR NECTIN2 CD226
4	Nectin adhesion pathway ¹	10.55	PVR NECTIN2

Sources

GO Terms for Mature Teratoma of the Ovary

Biological processes related to Mature Teratoma of the Ovary according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:0007155	9.76	SIGLEC5 PVR NECTIN2 CD226
2	regulation of immune response	GO:0050776	9.67	SLAMF6 PVR NECTIN2 CD226
3	positive regulation of interferon-gamma production	GO:0032729	9.49	SLAMF6 CD226
4	adherens junction organization	GO:0034332	9.48	PVR NECTIN2
5	positive regulation of T cell receptor signaling pathway	GO:0050862	9.43	NECTIN2 CD226
6	positive regulation of mast cell activation	GO:0033005	9.4	NECTIN2 CD226
7	susceptibility to natural killer cell mediated cytotoxicity	GO:0042271	9.32	PVR NECTIN2
8	positive regulation of immunoglobulin mediated immune response	GO:0002891	9.26	NECTIN2 CD226
9	susceptibility to T cell mediated cytotoxicity	GO:0060370	9.16	PVR NECTIN2
10	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	GO:0002860	9.13	PVR NECTIN2 CD226
11	positive regulation of natural killer cell mediated cytotoxicity	GO:0045954	8.92	SLAMF6 PVR NECTIN2 CD226

Molecular functions related to Mature Teratoma of the Ovary according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion molecule binding	GO:0050839	8.8	PVR NECTIN2 CD226

Sources

Sources for Mature Teratoma of the Ovary

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia