MCID: MXL017
MIFTS: 36

Maxillary Cancer

Categories: Bone diseases, Cancer diseases, Oral diseases

Aliases & Classifications for Maxillary Cancer

MalaCards integrated aliases for Maxillary Cancer:

Name: Maxillary Cancer 12 15
Maxillary Neoplasm 12 17
Upper Jaw Bone Cancer 12
Maxillary Neoplasms 45

Classifications:



External Ids:

Disease Ontology 12 DOID:4618
MeSH 45 D008441
UMLS 74 C0024954

Summaries for Maxillary Cancer

Disease Ontology : 12 A jaw cancer that effects the maxilla or upper jaw.

MalaCards based summary : Maxillary Cancer, also known as maxillary neoplasm, is related to jaw cancer and endometrial adenosquamous carcinoma. An important gene associated with Maxillary Cancer is HDAC3 (Histone Deacetylase 3), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and p53 Signaling. Affiliated tissues include bone, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Maxillary Cancer

Graphical network of the top 20 diseases related to Maxillary Cancer:



Diseases related to Maxillary Cancer

Symptoms & Phenotypes for Maxillary Cancer

GenomeRNAi Phenotypes related to Maxillary Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.35 CDC25A
2 Increased Nanog expression GR00371-A-3 9.35 CDC25A HDAC3 HDAC9
3 Increased Nanog expression GR00371-A-5 9.35 HDAC3
4 shRNA abundance <= 50% GR00343-S 9.23 CDC25A FOS GNB1L HDAC3 MMP2 PLAU

MGI Mouse Phenotypes related to Maxillary Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 CDC25A EGF FOS HDAC3 HDAC9 MMP2
2 hematopoietic system MP:0005397 9.92 CDC25A FOS GNB1L MMP2 PLAU PLG
3 immune system MP:0005387 9.86 EGF FOS GNB1L MMP2 PLAU PLG
4 mortality/aging MP:0010768 9.85 CDC25A FOS GNB1L HDAC3 HDAC9 MMP2
5 neoplasm MP:0002006 9.5 CDC25A FOS MMP2 PCBP4 PLAU PLG
6 vision/eye MP:0005391 9.1 EGF FOS MMP2 PLAU PLG SLC17A5

Drugs & Therapeutics for Maxillary Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Three-Dimensional Printing of Patient-Specific Titanium Plates in Jaw Surgery: A Pilot Study Recruiting NCT03057223 Not Applicable
2 Aesthetic Reconstruction of Onco-surgical Maxillary Defects Using FSF With and Without CAD/CAM Customized Cutting Guide Not yet recruiting NCT03757286 Not Applicable

Search NIH Clinical Center for Maxillary Cancer

Cochrane evidence based reviews: maxillary neoplasms

Genetic Tests for Maxillary Cancer

Anatomical Context for Maxillary Cancer

MalaCards organs/tissues related to Maxillary Cancer:

42
Bone

Publications for Maxillary Cancer

Articles related to Maxillary Cancer:

(show all 40)
# Title Authors Year
1
Suppression of SESN1 reduces cisplatin and hyperthermia resistance through increasing reactive oxygen species (ROS) in human maxillary cancer cells. ( 30300027 )
2018
2
Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment. ( 30447876 )
2018
3
Cerebellar Hemorrhage due to a Direct Carotid-Cavernous Fistula after Surgery for Maxillary Cancer. ( 28061497 )
2017
4
Prognostic value of computed tomography characteristics for overall survival in patients with maxillary cancer. ( 27724942 )
2016
5
Can preoperative computed tomography predict tissue origin of primary maxillary cancer? ( 27749536 )
2016
6
Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells. ( 26196957 )
2015
7
Dental Implants in Oral Rehabilitation of A Maxillary Cancer Reconstruction: A Case Report. ( 24444340 )
2015
8
Is elective neck dissection needed in clinically N0 neck in maxillary cancer? ( 25045635 )
2014
9
Management of the maxillary cancer patient--what the general dentist should know. ( 23909087 )
2013
10
Dosimetric and delivery characterizations of full-arc and half-arc volumetric-modulated arc therapy for maxillary cancer. ( 22843367 )
2012
11
Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo. ( 20417177 )
2010
12
Impact of superselective transarterial infusion therapy of high-dose cisplatin on maxillary cancer with orbital invasion. ( 20360344 )
2010
13
Malignant oral-maxillary neoplasm in children and adolescents. A retrospective analysis from the biopsy service at a school of dentistry in Argentina. ( 20302224 )
2009
14
Facial paralysis after superselective intra-arterial chemotherapy via the middle meningeal artery in maxillary cancer. ( 19111999 )
2009
15
The combined analgesic effect of gabapentin and transdermal fentanyl patch on acute and chronic pain after maxillary cancer surgeries. ( 23139472 )
2009
16
Inhibition of histone deacetylase 3 stimulates apoptosis induced by heat shock under acidic conditions in human maxillary cancer. ( 16044157 )
2005
17
Two cases of maxillary cancer with a similar clinical course and imaging findings but markedly different levels of FDG uptake. ( 16319642 )
2005
18
Maxillary cancer in a child: a case report. ( 12589863 )
2003
19
Acidic environment modifies heat- or radiation-induced apoptosis in human maxillary cancer cells. ( 11286847 )
2001
20
Appearance of bax protein after preoperative chemoradiotherapy is a prognostic factor in maxillary cancer. ( 11813905 )
2001
21
Magnetic resonance imaging of maxillary cancer--possibility of detecting bone destruction. ( 11036242 )
2000
22
Implant-supported prostheses after maxillary cancer resection: preliminary report. ( 9477779 )
1997
23
Inhibitory effects of selenium, vitamin A and butylated hydroxytoluene on growth of human maxillary cancer cells in vitro. ( 8809329 )
1996
24
Three-dimensional treatment planning for maxillary cancer using a CT simulator. ( 7961002 )
1994
25
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor. ( 8240657 )
1993
26
Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines. ( 1610070 )
1992
27
Appearance of drug-resistant tumor cells in a maxillary cancer patient undergoing chemotherapy and chemoradiotherapy. ( 1696435 )
1990
28
A study of the late effects of radiotherapy and operation on patients with maxillary cancer. A survey more than 10 years after initial treatment. ( 3179925 )
1988
29
Staging of maxillary cancer. Which classification? ( 3566055 )
1987
30
Analysis of the long-term results of our combination therapy for maxillary cancer, with particular reference to treatment of T4 and N1-3 maxillary cancer. ( 3836633 )
1985
31
Facial swelling, dental extraction and maxillary cancer. ( 6710267 )
1984
32
Primary reconstruction after total or extended total maxillectomy for maxillary cancer. ( 7208686 )
1981
33
Analysis of the results of our combined therapy for maxillary cancer. ( 6267873 )
1980
34
Treatment of maxillary cancer with three-combined method. ( 6929895 )
1980
35
Use of phytohemagglutinin in the treatment of maxillary cancer. ( 7458763 )
1980
36
Axial transverse tomography of maxillary cancer. ( 25629852 )
1975
37
Axial transverse tomography of maxillary cancer. ( 4732234 )
1973
38
Application of hydrogen peroxide infusion to maxillary cancer. ( 5592199 )
1967
39
CHROMOSOMES OF HUMAN TUMORS. V. CHROMOSOMAL ALTERATION IN THE METASTATIC LESION OF A MAXILLARY CANCER. ( 14295272 )
1964
40
Natural history of maxillary neoplasm. ( 14405930 )
1960

Variations for Maxillary Cancer

Expression for Maxillary Cancer

Search GEO for disease gene expression data for Maxillary Cancer.

Pathways for Maxillary Cancer

Pathways related to Maxillary Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 FOS MMP2 PLG TIMP1
2
Show member pathways
12.03 FOS HDAC3 HDAC9
3 11.85 MMP2 PCBP4 SESN1
4 11.77 FOS MMP2 TIMP1
5
Show member pathways
11.67 MMP2 PLG TIMP1
6 11.64 FOS HDAC3 HDAC9 MMP2
7 11.52 CDC25A PLAU TYMS
8
Show member pathways
11.48 CDC25A FOS TYMS
9
Show member pathways
11.41 EGF FOS MMP2
10 11.35 FOS MMP2 PLAU
11
Show member pathways
11.3 FOS HDAC3 HDAC9
12 11.23 MMP2 PLAU PLG
13 11.19 FOS HDAC3 HDAC9 MMP2
14
Show member pathways
11.15 FOS MMP2 PLAU
15 11.14 HDAC3 HDAC9
16 11.13 MMP2 PLAU
17
Show member pathways
11.07 FOS TIMP1
18 11.06 EGF MMP2 PLAU TIMP1
19 10.94 MMP2 PLG
20 10.89 MMP2 PLG
21 10.71 MMP2 PLAU PLG TIMP1
22 10.62 PLAU PLG

GO Terms for Maxillary Cancer

Cellular components related to Maxillary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.8 EGF PLG TIMP1

Biological processes related to Maxillary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.58 FOS TIMP1 TYMS
2 platelet degranulation GO:0002576 9.43 EGF PLG TIMP1
3 fibrinolysis GO:0042730 9.37 PLAU PLG
4 histone H3 deacetylation GO:0070932 9.32 HDAC3 HDAC9
5 histone H4 deacetylation GO:0070933 9.16 HDAC3 HDAC9
6 extracellular matrix disassembly GO:0022617 9.13 MMP2 PLG TIMP1
7 response to cytokine GO:0034097 8.8 FOS TIMP1 TYMS

Molecular functions related to Maxillary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.63 CDC25A HDAC3 HDAC9 MMP2 PLAU PLG
2 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 8.96 HDAC3 HDAC9
3 protein deacetylase activity GO:0033558 8.62 HDAC3 HDAC9

Sources for Maxillary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....