MCID: MXL017
MIFTS: 36

Maxillary Cancer

Categories: Bone diseases, Cancer diseases, Oral diseases

Aliases & Classifications for Maxillary Cancer

MalaCards integrated aliases for Maxillary Cancer:

Name: Maxillary Cancer 12 15
Upper Jaw Bone Cancer 12
Maxillary Neoplasms 44
Maxillary Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4618
MeSH 44 D008441
UMLS 73 C0024954

Summaries for Maxillary Cancer

Disease Ontology : 12 A jaw cancer that effects the maxilla or upper jaw.

MalaCards based summary : Maxillary Cancer, also known as upper jaw bone cancer, is related to jaw cancer and endometrial adenosquamous carcinoma. An important gene associated with Maxillary Cancer is HDAC3 (Histone Deacetylase 3), and among its related pathways/superpathways are Phospholipase-C Pathway and Immune response IL-23 signaling pathway. Affiliated tissues include bone, lung and lymph node, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Decreased TP53 mRNA expression

Related Diseases for Maxillary Cancer

Graphical network of the top 20 diseases related to Maxillary Cancer:



Diseases related to Maxillary Cancer

Symptoms & Phenotypes for Maxillary Cancer

GenomeRNAi Phenotypes related to Maxillary Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDC25A HDAC3 SESN1 TP53 TYMS
2 Decreased TP53 mRNA expression GR00389-S-5 8.96 HDAC9 TP53

MGI Mouse Phenotypes related to Maxillary Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.9 CDC25A EGF FOS HDAC3 HDAC9 MMP2
2 mortality/aging MP:0010768 9.65 CDC25A FOS GNB1L HDAC3 HDAC9 MMP2
3 neoplasm MP:0002006 9.17 CDC25A FOS MMP2 PCBP4 PLAU TIMP1

Drugs & Therapeutics for Maxillary Cancer

Search Clinical Trials , NIH Clinical Center for Maxillary Cancer

Cochrane evidence based reviews: maxillary neoplasms

Genetic Tests for Maxillary Cancer

Anatomical Context for Maxillary Cancer

MalaCards organs/tissues related to Maxillary Cancer:

41
Bone, Lung, Lymph Node, Tongue, Spinal Cord

Publications for Maxillary Cancer

Articles related to Maxillary Cancer:

(show all 38)
# Title Authors Year
1
Suppression of SESN1 reduces cisplatin and hyperthermia resistance through increasing reactive oxygen species (ROS) in human maxillary cancer cells. ( 30300027 )
2018
2
Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment. ( 30447876 )
2018
3
Cerebellar Hemorrhage due to a Direct Carotid-Cavernous Fistula after Surgery for Maxillary Cancer. ( 28061497 )
2017
4
Prognostic value of computed tomography characteristics for overall survival in patients with maxillary cancer. ( 27724942 )
2016
5
Can preoperative computed tomography predict tissue origin of primary maxillary cancer? ( 27749536 )
2016
6
Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells. ( 26196957 )
2015
7
Dental Implants in Oral Rehabilitation of A Maxillary Cancer Reconstruction: A Case Report. ( 24444340 )
2015
8
Is elective neck dissection needed in clinically N0 neck in maxillary cancer? ( 25045635 )
2014
9
Management of the maxillary cancer patient--what the general dentist should know. ( 23909087 )
2013
10
Dosimetric and delivery characterizations of full-arc and half-arc volumetric-modulated arc therapy for maxillary cancer. ( 22843367 )
2012
11
Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo. ( 20417177 )
2010
12
Impact of superselective transarterial infusion therapy of high-dose cisplatin on maxillary cancer with orbital invasion. ( 20360344 )
2010
13
Facial paralysis after superselective intra-arterial chemotherapy via the middle meningeal artery in maxillary cancer. ( 19111999 )
2009
14
The combined analgesic effect of gabapentin and transdermal fentanyl patch on acute and chronic pain after maxillary cancer surgeries. ( 23139472 )
2009
15
Inhibition of histone deacetylase 3 stimulates apoptosis induced by heat shock under acidic conditions in human maxillary cancer. ( 16044157 )
2005
16
Two cases of maxillary cancer with a similar clinical course and imaging findings but markedly different levels of FDG uptake. ( 16319642 )
2005
17
Maxillary cancer in a child: a case report. ( 12589863 )
2003
18
Acidic environment modifies heat- or radiation-induced apoptosis in human maxillary cancer cells. ( 11286847 )
2001
19
Appearance of bax protein after preoperative chemoradiotherapy is a prognostic factor in maxillary cancer. ( 11813905 )
2001
20
Magnetic resonance imaging of maxillary cancer--possibility of detecting bone destruction. ( 11036242 )
2000
21
Implant-supported prostheses after maxillary cancer resection: preliminary report. ( 9477779 )
1997
22
Inhibitory effects of selenium, vitamin A and butylated hydroxytoluene on growth of human maxillary cancer cells in vitro. ( 8809329 )
1996
23
Three-dimensional treatment planning for maxillary cancer using a CT simulator. ( 7961002 )
1994
24
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor. ( 8240657 )
1993
25
Heterogeneity in epidermal growth factor responsiveness and tumor growth of human maxillary cancer cell lines. ( 1610070 )
1992
26
Appearance of drug-resistant tumor cells in a maxillary cancer patient undergoing chemotherapy and chemoradiotherapy. ( 1696435 )
1990
27
A study of the late effects of radiotherapy and operation on patients with maxillary cancer. A survey more than 10 years after initial treatment. ( 3179925 )
1988
28
Staging of maxillary cancer. Which classification? ( 3566055 )
1987
29
Analysis of the long-term results of our combination therapy for maxillary cancer, with particular reference to treatment of T4 and N1-3 maxillary cancer. ( 3836633 )
1985
30
Facial swelling, dental extraction and maxillary cancer. ( 6710267 )
1984
31
Primary reconstruction after total or extended total maxillectomy for maxillary cancer. ( 7208686 )
1981
32
Analysis of the results of our combined therapy for maxillary cancer. ( 6267873 )
1980
33
Treatment of maxillary cancer with three-combined method. ( 6929895 )
1980
34
Use of phytohemagglutinin in the treatment of maxillary cancer. ( 7458763 )
1980
35
Axial transverse tomography of maxillary cancer. ( 25629852 )
1975
36
Axial transverse tomography of maxillary cancer. ( 4732234 )
1973
37
Application of hydrogen peroxide infusion to maxillary cancer. ( 5592199 )
1967
38
CHROMOSOMES OF HUMAN TUMORS. V. CHROMOSOMAL ALTERATION IN THE METASTATIC LESION OF A MAXILLARY CANCER. ( 14295272 )
1964

Variations for Maxillary Cancer

Expression for Maxillary Cancer

Search GEO for disease gene expression data for Maxillary Cancer.

Pathways for Maxillary Cancer

Pathways related to Maxillary Cancer according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 EGF HDAC3 HDAC9 TIMP1 TP53
2
Show member pathways
12.43 FOS MMP2 TIMP1 TP53
3
Show member pathways
12.38 EGF FOS MMP2 TP53
4 12.36 CDC25A FOS TP53 TYMS
5
Show member pathways
12.16 CDC25A HDAC3 HDAC9 TP53
6 12.02 EGF MMP2 TP53
7
Show member pathways
11.98 FOS HDAC3 HDAC9 TP53
8 11.94 FOS MMP2 TP53
9 11.74 MMP2 PCBP4 SESN1 TP53
10 11.7 CDC25A TP53 TYMS
11
Show member pathways
11.66 HDAC3 HDAC9 TP53
12 11.61 FOS MMP2 TIMP1 TP53
13 11.59 EGF MMP2 TP53
14 11.58 CDC25A PLAU TYMS
15
Show member pathways
11.55 CDC25A FOS TYMS
16
Show member pathways
11.47 EGF FOS MMP2
17 11.46 MMP2 PLAU TIMP1
18 11.44 FOS HDAC3 HDAC9 MMP2 TP53
19 11.39 FOS MMP2 PLAU
20
Show member pathways
11.35 FOS HDAC3 HDAC9
21 11.32 FOS MMP2 TP53
22 11.26 EGF MMP2 PLAU TIMP1
23
Show member pathways
11.2 FOS MMP2 PLAU
24 10.75 FOS HDAC3 HDAC9 MMP2 TP53
25
Show member pathways
10.46 PCBP4 TP53

GO Terms for Maxillary Cancer

Biological processes related to Maxillary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 FOS MMP2 TIMP1 TP53
2 histone H3 deacetylation GO:0070932 9.26 HDAC3 HDAC9
3 histone H4 deacetylation GO:0070933 8.96 HDAC3 HDAC9
4 response to cytokine GO:0034097 8.8 FOS TIMP1 TYMS

Molecular functions related to Maxillary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 9.43 HDAC3 HDAC9 TP53
2 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 9.16 HDAC3 HDAC9
3 transcription factor binding GO:0008134 9.02 FOS HDAC3 HDAC9 SRY TP53
4 protein deacetylase activity GO:0033558 8.96 HDAC3 HDAC9

Sources for Maxillary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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