MCID: MXL006
MIFTS: 32

Maxillary Sinus Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Maxillary Sinus Adenocarcinoma

MalaCards integrated aliases for Maxillary Sinus Adenocarcinoma:

Name: Maxillary Sinus Adenocarcinoma 12 15 71
Adenocarcinoma of the Maxillary Sinus 12
Adenocarcinoma of Maxillary Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7684
NCIt 49 C6240
UMLS 71 C1334642

Summaries for Maxillary Sinus Adenocarcinoma

MalaCards based summary : Maxillary Sinus Adenocarcinoma, also known as adenocarcinoma of the maxillary sinus, is related to adenocarcinoma and low-grade astrocytoma, and has symptoms including pain and rhinorrhea. An important gene associated with Maxillary Sinus Adenocarcinoma is COPS5 (COP9 Signalosome Subunit 5), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. Related phenotypes are Reduced mammosphere formation and Decreased TP53 mRNA expression

Related Diseases for Maxillary Sinus Adenocarcinoma

Diseases related to Maxillary Sinus Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.1
2 low-grade astrocytoma 10.0 TP53 CDKN1B
3 liver benign neoplasm 10.0 TP53 CYP1A2
4 ring chromosome 7 10.0 TP53 MDM2
5 ring chromosome 10.0 TP53 MDM2
6 osteogenic sarcoma 10.0
7 clear cell adenocarcinoma 10.0
8 polymorphous low-grade adenocarcinoma 10.0
9 rare tumor 10.0
10 crisponi/cold-induced sweating syndrome 2 10.0 STAT1 FASLG
11 squamous cell carcinoma 10.0
12 maxillary sinus squamous cell carcinoma 10.0
13 actinic cheilitis 10.0 TP53 MDM2
14 cheilitis 10.0 TP53 MDM2
15 esophagus verrucous carcinoma 10.0 TP53 MDM2
16 verrucous carcinoma 10.0 TP53 MDM2
17 bone giant cell sarcoma 9.9 TP53 MDM2
18 soft tissue sarcoma 9.9 TP53 MDM2
19 parameningeal embryonal rhabdomyosarcoma 9.9 TP53 MDM2
20 embryonal sarcoma 9.9 TP53 MDM2
21 acute myocarditis 9.9 STAT1 FASLG
22 dedifferentiated liposarcoma 9.9 TP53 MDM2
23 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9 STAT1 LRBA
24 conventional fibrosarcoma 9.9 TP53 MDM2
25 lip cancer 9.9 TP53 MDM2
26 uterine adnexa cancer 9.9 TP53 MDM2
27 anal squamous cell carcinoma 9.9 TP53 MDM2
28 spindle cell sarcoma 9.8 MDM2 CDKN1B
29 acantholytic acanthoma 9.8 FASLG ATM
30 t-cell prolymphocytic leukemia 9.8 CDKN1B ATM
31 bone osteosarcoma 9.8 TP53 MDM2
32 inverted papilloma 9.8 TP53 CDKN1B
33 gliomatosis cerebri 9.8 TP53 MDM2
34 mediastinum liposarcoma 9.7 MDM2 ATM
35 urethra clear cell adenocarcinoma 9.7 TP53 ATM
36 familial retinoblastoma 9.7 TP53 MDM2 E2F2
37 mediastinum sarcoma 9.7 MDM2 ATM
38 connective tissue benign neoplasm 9.7 TP53 MDM2
39 cll/sll 9.7 TP53 ATM
40 richter's syndrome 9.6 TP53 ATM
41 endocervical adenocarcinoma 9.6 TP53 CDKN1B
42 cardia cancer 9.5 TP53 MDM2
43 female breast cancer 9.5 TP53 CDKN1B ATM
44 retinoblastoma 9.4 TP53 MDM2 E2F2 CDKN1B
45 ocular cancer 9.4 TP53 MDM2 E2F2 CDKN1B
46 childhood leukemia 9.3 TP53 MDM2 ATM
47 ovary adenocarcinoma 9.3 TP53 MDM2 ATM
48 li-fraumeni syndrome 9.3 TP53 MDM2 ATM
49 ataxia-telangiectasia 9.3 TP53 MDM2 ATM
50 malignant glioma 9.3 TP53 MDM2 ATM

Graphical network of the top 20 diseases related to Maxillary Sinus Adenocarcinoma:



Diseases related to Maxillary Sinus Adenocarcinoma

Symptoms & Phenotypes for Maxillary Sinus Adenocarcinoma

UMLS symptoms related to Maxillary Sinus Adenocarcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 ATM COPS5 E2F2 FASLG MDM2 STAT1
2 Decreased TP53 mRNA expression GR00389-S-5 8.96 ATM TP53

MGI Mouse Phenotypes related to Maxillary Sinus Adenocarcinoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.13 ATM CDKN1B COPS5 CYP1A2 E2F2 FASLG
2 cellular MP:0005384 10.11 ATM CDKN1B COPS5 E2F2 FASLG MDM2
3 hematopoietic system MP:0005397 10.09 ATM CDKN1B COPS5 E2F2 FASLG LRBA
4 cardiovascular system MP:0005385 10.07 ATM CDKN1B CYP1A2 FASLG MDM2 STAT1
5 growth/size/body region MP:0005378 10.06 ATM CDKN1B COPS5 E2F2 LRBA MDM2
6 homeostasis/metabolism MP:0005376 10.06 ATM CDKN1B COPS5 CYP1A2 FASLG LRBA
7 immune system MP:0005387 10.02 ATM CDKN1B COPS5 E2F2 FASLG LRBA
8 digestive/alimentary MP:0005381 9.97 CDKN1B FASLG LRBA MDM2 STAT1 TP53
9 integument MP:0010771 9.87 ATM CDKN1B E2F2 FASLG MDM2 STAT1
10 mortality/aging MP:0010768 9.81 ATM CDKN1B COPS5 CYP1A2 E2F2 FASLG
11 liver/biliary system MP:0005370 9.8 CDKN1B CYP1A2 E2F2 FASLG MDM2 STAT1
12 neoplasm MP:0002006 9.5 ATM CDKN1B CYP1A2 FASLG MDM2 STAT1
13 normal MP:0002873 9.1 COPS5 E2F2 FASLG MDM2 STAT1 TP53

Drugs & Therapeutics for Maxillary Sinus Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Maxillary Sinus Adenocarcinoma

Genetic Tests for Maxillary Sinus Adenocarcinoma

Anatomical Context for Maxillary Sinus Adenocarcinoma

Publications for Maxillary Sinus Adenocarcinoma

Articles related to Maxillary Sinus Adenocarcinoma:

(show all 12)
# Title Authors PMID Year
1
Trigeminocardiac Reflex as the Presentation of Maxillary Sinus Adenocarcinoma. 61
28601537 2017
2
Differential diagnosis of a carcinoma of the maxillary sinus that resembles a sparganum infection: A case report. 61
26622486 2015
3
Polymorphous low-grade adenocarcinoma of the maxillary sinus. 61
23714964 2013
4
Unilateral maxillary swelling: a retrospective study. 61
22319702 2010
5
Clear cell adenocarcinoma of the maxillary sinus: a case report. 61
15027741 2003
6
Metachronous adenocarcinoma of the maxillary sinuses: a rare entity. 61
12537620 2002
7
Primary adenocarcinoma of the maxillary sinus simulating an osteosarcoma. 61
11816380 2002
8
Signet-ring cell adenocarcinoma metastatic to the maxillary sinus. 61
1318534 1992
9
Predominance of squamous cell carcinoma and rarity of adenocarcinoma of maxillary sinus among Japanese. 61
2671488 1989
10
Respiratory cancers in furniture workers. 61
4005193 1985
11
Acinic cell adenocarcinoma of the maxillary sinus. 61
4491105 1973
12
[Adenocarcinoma of the maxillary sinus and ethmoid labyrinth]. 61
5622900 1967

Variations for Maxillary Sinus Adenocarcinoma

Expression for Maxillary Sinus Adenocarcinoma

Search GEO for disease gene expression data for Maxillary Sinus Adenocarcinoma.

Pathways for Maxillary Sinus Adenocarcinoma

Pathways related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TP53 STAT1 MDM2 FASLG E2F2 CDKN1B
2
Show member pathways
13.28 TP53 STAT1 MDM2 FASLG CDKN1B
3
Show member pathways
13.04 TP53 MDM2 E2F2 CDKN1B ATM
4
Show member pathways
12.86 TP53 STAT1 MDM2 FASLG CDKN1B ATM
5
Show member pathways
12.85 TP53 MDM2 CDKN1B ATM
6
Show member pathways
12.79 TP53 STAT1 MDM2 E2F2 CDKN1B
7
Show member pathways
12.78 TP53 STAT1 MDM2 FASLG E2F2 ATM
8
Show member pathways
12.71 TP53 MDM2 FASLG ATM
9 12.64 TP53 STAT1 MDM2 FASLG E2F2 CDKN1B
10
Show member pathways
12.58 TP53 MDM2 E2F2 CDKN1B ATM
11
Show member pathways
12.56 TP53 MDM2 CDKN1B ATM
12
Show member pathways
12.54 TP53 STAT1 MDM2 CDKN1B
13
Show member pathways
12.51 TP53 STAT1 MDM2 FASLG E2F2 CDKN1B
14
Show member pathways
12.49 TP53 MDM2 E2F2 CDKN1B ATM
15 12.43 TP53 MDM2 E2F2 CDKN1B ATM
16
Show member pathways
12.41 TP53 STAT1 MDM2
17 12.39 TP53 MDM2 COPS5 CDKN1B ATM
18
Show member pathways
12.34 TP53 MDM2 FASLG E2F2 CDKN1B ATM
19
Show member pathways
12.32 TP53 MDM2 CDKN1B ATM
20
Show member pathways
12.3 TP53 E2F2 CDKN1B ATM
21 12.28 TP53 MDM2 ATM
22
Show member pathways
12.25 TP53 CDKN1B ATM
23 12.25 TP53 E2F2 ATM
24
Show member pathways
12.24 TP53 STAT1 MDM2 FASLG CDKN1B
25 12.21 TP53 MDM2 FASLG
26 12.2 TP53 MDM2 CDKN1B
27 12.19 TP53 MDM2 CDKN1B ATM
28 12.16 TP53 MDM2 E2F2 CDKN1B ATM
29
Show member pathways
12.15 TP53 MDM2 E2F2 CDKN1B
30
Show member pathways
12.14 TP53 STAT1 CDKN1B
31 12.12 TP53 MDM2 E2F2 ATM
32 12.09 TP53 STAT1 MDM2 ATM
33
Show member pathways
12.02 MDM2 FASLG CDKN1B ATM
34
Show member pathways
11.98 TP53 STAT1 ATM
35 11.95 TP53 STAT1 MDM2
36 11.93 TP53 STAT1 FASLG
37 11.9 TP53 MDM2 E2F2 CDKN1B
38 11.89 TP53 MDM2 CDKN1B
39
Show member pathways
11.83 TP53 MDM2 FASLG E2F2 ATM
40 11.82 TP53 E2F2 CDKN1B
41
Show member pathways
11.79 TP53 MDM2 ATM
42 11.76 TP53 STAT1 MDM2
43 11.74 TP53 MDM2 E2F2 CDKN1B
44
Show member pathways
11.71 TP53 MDM2 ATM
45 11.7 E2F2 CDKN1B ATM
46 11.7 TP53 MDM2 E2F2
47
Show member pathways
11.7 TP53 STAT1 E2F2 ATM
48 11.62 TP53 MDM2 ATM
49 11.6 TP53 MDM2 ATM
50 11.55 TP53 MDM2 COPS5

GO Terms for Maxillary Sinus Adenocarcinoma

Biological processes related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10 TP53 STAT1 E2F2 COPS5 ATM
2 cell cycle GO:0007049 9.93 TP53 E2F2 CDKN1B ATM
3 negative regulation of apoptotic process GO:0043066 9.91 TP53 MDM2 COPS5 CDKN1B
4 positive regulation of cell proliferation GO:0008284 9.91 STAT1 MDM2 FASLG CDKN1B
5 negative regulation of transcription by RNA polymerase II GO:0000122 9.89 TP53 STAT1 MDM2 FASLG E2F2
6 regulation of cell proliferation GO:0042127 9.8 TP53 STAT1 CDKN1B
7 cell cycle arrest GO:0007050 9.73 TP53 CDKN1B ATM
8 regulation of signal transduction by p53 class mediator GO:1901796 9.72 TP53 MDM2 ATM
9 response to organic cyclic compound GO:0014070 9.71 STAT1 CYP1A2 CDKN1B
10 heart development GO:0007507 9.71 TP53 MDM2 CDKN1B ATM
11 negative regulation of mitotic cell cycle GO:0045930 9.64 TP53 CDKN1B
12 response to amino acid GO:0043200 9.64 TP53 CDKN1B
13 response to antibiotic GO:0046677 9.63 TP53 MDM2
14 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.62 TP53 E2F2
15 cellular response to organic cyclic compound GO:0071407 9.61 STAT1 MDM2 CDKN1B
16 necroptotic process GO:0070266 9.59 TP53 FASLG
17 positive regulation of protein export from nucleus GO:0046827 9.58 TP53 MDM2
18 determination of adult lifespan GO:0008340 9.58 TP53 ATM
19 mitotic cell cycle arrest GO:0071850 9.57 TP53 CDKN1B
20 regulation of cell cycle GO:0051726 9.56 TP53 E2F2 COPS5 ATM
21 positive regulation of neuron apoptotic process GO:0043525 9.54 TP53 FASLG ATM
22 cardiac septum morphogenesis GO:0060411 9.52 TP53 MDM2
23 replicative senescence GO:0090399 9.51 TP53 ATM
24 cellular response to antibiotic GO:0071236 9.48 MDM2 CDKN1B
25 cellular response to UV-C GO:0071494 9.46 TP53 MDM2
26 response to drug GO:0042493 9.35 TP53 STAT1 MDM2 CYP1A2 CDKN1B
27 cellular response to gamma radiation GO:0071480 9.33 TP53 MDM2 ATM
28 cellular response to actinomycin D GO:0072717 9.32 TP53 MDM2
29 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.92 TP53 MDM2 CDKN1B ATM

Molecular functions related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 9.32 TP53 STAT1
2 tumor necrosis factor receptor binding GO:0005164 9.26 STAT1 FASLG
3 histone acetyltransferase binding GO:0035035 9.16 TP53 STAT1
4 protein N-terminus binding GO:0047485 9.13 TP53 MDM2 ATM
5 enzyme binding GO:0019899 9.02 TP53 STAT1 MDM2 CYP1A2 COPS5

Sources for Maxillary Sinus Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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