MCID: MXL006
MIFTS: 32

Maxillary Sinus Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Maxillary Sinus Adenocarcinoma

MalaCards integrated aliases for Maxillary Sinus Adenocarcinoma:

Name: Maxillary Sinus Adenocarcinoma 12 15 71
Adenocarcinoma of the Maxillary Sinus 12
Adenocarcinoma of Maxillary Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7684
NCIt 49 C6240
UMLS 71 C1334642

Summaries for Maxillary Sinus Adenocarcinoma

MalaCards based summary : Maxillary Sinus Adenocarcinoma, also known as adenocarcinoma of the maxillary sinus, is related to ethmoid sinus adenocarcinoma and ethmoid sinus cancer, and has symptoms including pain and rhinorrhea. An important gene associated with Maxillary Sinus Adenocarcinoma is SERPINB3 (Serpin Family B Member 3), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. Related phenotypes are Reduced mammosphere formation and endocrine/exocrine gland

Related Diseases for Maxillary Sinus Adenocarcinoma

Diseases related to Maxillary Sinus Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 ethmoid sinus adenocarcinoma 10.3 SERPINB3 CXCL11
2 ethmoid sinus cancer 10.3 SERPINB3 CXCL11
3 anal carcinoma in situ 10.2 TP53 SERPINB3
4 adenocarcinoma 10.2
5 parotid gland cancer 10.2 TP53 SERPINB3
6 paratesticular lipoma 10.1 SERPINB3 MDM2
7 lipoma of spermatic cord 10.1 SERPINB3 MDM2
8 laryngeal benign neoplasm 10.1 TP53 SERPINB3
9 low-grade astrocytoma 10.0 TP53 CDKN1B
10 anus cancer 10.0 TP53 SERPINB3
11 osteogenic sarcoma 10.0
12 clear cell adenocarcinoma 10.0
13 polymorphous low-grade adenocarcinoma 10.0
14 rare tumor 10.0
15 ring chromosome 7 10.0 TP53 MDM2
16 hypopharynx cancer 10.0 TP53 SERPINB3
17 ring chromosome 10.0 TP53 MDM2
18 nasal cavity cancer 10.0 TP53 SERPINB3 CXCL11
19 squamous cell carcinoma 10.0
20 maxillary sinus squamous cell carcinoma 10.0
21 actinic cheilitis 10.0 TP53 MDM2
22 esophagus verrucous carcinoma 9.9 TP53 MDM2
23 periosteal osteogenic sarcoma 9.9 TP53 MDM2
24 inverted papilloma 9.9 TP53 SERPINB3 CDKN1B
25 soft tissue sarcoma 9.9 TP53 MDM2
26 peripheral osteosarcoma 9.9 TP53 MDM2
27 parameningeal embryonal rhabdomyosarcoma 9.9 TP53 MDM2
28 embryonal sarcoma 9.9 TP53 MDM2
29 adult astrocytic tumour 9.9 TP53 MDM2
30 malignant spiradenoma 9.9 TP53 MDM2
31 conventional fibrosarcoma 9.9 TP53 MDM2
32 uterine adnexa cancer 9.9 TP53 MDM2
33 lip cancer 9.8 TP53 MDM2
34 anal squamous cell carcinoma 9.8 TP53 MDM2
35 familial retinoblastoma 9.7 TP53 MDM2 E2F2
36 mediastinum liposarcoma 9.7 MDM2 ATM
37 cervical adenoma malignum 9.7 TP53 ATM
38 t-cell prolymphocytic leukemia 9.7 CDKN1B ATM
39 chromosome 13q14 deletion syndrome 9.6 TP53 ATM
40 gliomatosis cerebri 9.5 TP53 MDM2
41 tongue carcinoma 9.5 TP53 MDM2 FASLG
42 acute myocarditis 9.5 STAT1 FASLG
43 cll/sll 9.5 TP53 ATM
44 prolymphocytic leukemia 9.5 TP53 CDKN1B ATM
45 female breast cancer 9.5 TP53 CDKN1B ATM
46 retinoblastoma 9.4 TP53 MDM2 E2F2 CDKN1B
47 ocular cancer 9.4 TP53 MDM2 E2F2 CDKN1B
48 sporadic breast cancer 9.3 TP53 MDM2 ATM
49 childhood leukemia 9.3 TP53 MDM2 ATM
50 ovary adenocarcinoma 9.3 TP53 MDM2 ATM

Graphical network of the top 20 diseases related to Maxillary Sinus Adenocarcinoma:



Diseases related to Maxillary Sinus Adenocarcinoma

Symptoms & Phenotypes for Maxillary Sinus Adenocarcinoma

UMLS symptoms related to Maxillary Sinus Adenocarcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 ATM COPS5 E2F2 FASLG MDM2 STAT1

MGI Mouse Phenotypes related to Maxillary Sinus Adenocarcinoma:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.16 ATM CDKN1B COPS5 CYP1A2 E2F2 FASLG
2 cellular MP:0005384 10.1 ATM CDKN1B COPS5 E2F2 FASLG MDM2
3 hematopoietic system MP:0005397 10.09 ATM CDKN1B COPS5 E2F2 FASLG LRBA
4 homeostasis/metabolism MP:0005376 10.06 ATM CDKN1B COPS5 CYP1A2 FASLG LRBA
5 immune system MP:0005387 10.02 ATM CDKN1B COPS5 E2F2 FASLG LRBA
6 digestive/alimentary MP:0005381 9.95 CDKN1B FASLG LRBA MDM2 STAT1 TP53
7 integument MP:0010771 9.87 ATM CDKN1B E2F2 FASLG MDM2 STAT1
8 liver/biliary system MP:0005370 9.8 CDKN1B CYP1A2 E2F2 FASLG MDM2 STAT1
9 neoplasm MP:0002006 9.7 ATM CDKN1B CYP1A2 FASLG MDM2 STAT1
10 normal MP:0002873 9.5 COPS5 CYP1A2 E2F2 FASLG MDM2 STAT1
11 respiratory system MP:0005388 9.1 CDKN1B CYP1A2 E2F2 FASLG STAT1 TP53

Drugs & Therapeutics for Maxillary Sinus Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Maxillary Sinus Adenocarcinoma

Genetic Tests for Maxillary Sinus Adenocarcinoma

Anatomical Context for Maxillary Sinus Adenocarcinoma

Publications for Maxillary Sinus Adenocarcinoma

Articles related to Maxillary Sinus Adenocarcinoma:

(show all 12)
# Title Authors PMID Year
1
Trigeminocardiac Reflex as the Presentation of Maxillary Sinus Adenocarcinoma. 61
28601537 2017
2
Differential diagnosis of a carcinoma of the maxillary sinus that resembles a sparganum infection: A case report. 61
26622486 2015
3
Polymorphous low-grade adenocarcinoma of the maxillary sinus. 61
23714964 2013
4
Unilateral maxillary swelling: a retrospective study. 61
22319702 2010
5
Clear cell adenocarcinoma of the maxillary sinus: a case report. 61
15027741 2003
6
Metachronous adenocarcinoma of the maxillary sinuses: a rare entity. 61
12537620 2002
7
Primary adenocarcinoma of the maxillary sinus simulating an osteosarcoma. 61
11816380 2002
8
Signet-ring cell adenocarcinoma metastatic to the maxillary sinus. 61
1318534 1992
9
Predominance of squamous cell carcinoma and rarity of adenocarcinoma of maxillary sinus among Japanese. 61
2671488 1989
10
Respiratory cancers in furniture workers. 61
4005193 1985
11
Acinic cell adenocarcinoma of the maxillary sinus. 61
4491105 1973
12
[Adenocarcinoma of the maxillary sinus and ethmoid labyrinth]. 61
5622900 1967

Variations for Maxillary Sinus Adenocarcinoma

Expression for Maxillary Sinus Adenocarcinoma

Search GEO for disease gene expression data for Maxillary Sinus Adenocarcinoma.

Pathways for Maxillary Sinus Adenocarcinoma

Pathways related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TP53 STAT1 MDM2 FASLG E2F2 CXCL11
2
Show member pathways
13.32 TP53 STAT1 MDM2 FASLG CXCL11 CDKN1B
3
Show member pathways
13.05 TP53 MDM2 E2F2 CDKN1B ATM
4
Show member pathways
12.98 TP53 STAT1 FASLG E2F2 CXCL11
5
Show member pathways
12.89 TP53 STAT1 MDM2 FASLG CDKN1B ATM
6
Show member pathways
12.81 TP53 STAT1 MDM2 FASLG E2F2 ATM
7
Show member pathways
12.8 TP53 STAT1 MDM2 E2F2 CDKN1B
8 12.68 TP53 STAT1 MDM2 FASLG E2F2 CDKN1B
9
Show member pathways
12.63 TP53 MDM2 FASLG ATM
10
Show member pathways
12.59 TP53 MDM2 E2F2 CDKN1B ATM
11
Show member pathways
12.59 TP53 STAT1 MDM2 FASLG E2F2 CDKN1B
12
Show member pathways
12.57 TP53 MDM2 CDKN1B ATM
13
Show member pathways
12.55 TP53 STAT1 MDM2 CDKN1B
14
Show member pathways
12.48 TP53 MDM2 E2F2 CDKN1B ATM
15 12.45 TP53 MDM2 E2F2 CDKN1B ATM
16 12.39 TP53 MDM2 COPS5 CDKN1B ATM
17
Show member pathways
12.34 TP53 MDM2 FASLG E2F2 CDKN1B ATM
18
Show member pathways
12.33 TP53 MDM2 CDKN1B ATM
19
Show member pathways
12.3 TP53 E2F2 CDKN1B ATM
20
Show member pathways
12.24 TP53 STAT1 MDM2 FASLG CDKN1B
21
Show member pathways
12.22 TP53 STAT1 CDKN1B
22 12.21 TP53 MDM2 CDKN1B ATM
23
Show member pathways
12.17 TP53 MDM2 E2F2 CDKN1B
24 12.13 TP53 MDM2 E2F2 CDKN1B ATM
25
Show member pathways
12.11 STAT1 FASLG CXCL11
26 12.11 TP53 MDM2 E2F2 ATM
27 12.09 TP53 STAT1 MDM2 ATM
28
Show member pathways
12.02 MDM2 FASLG CDKN1B ATM
29
Show member pathways
12 TP53 STAT1 ATM
30 11.96 TP53 STAT1 MDM2
31 11.93 TP53 STAT1 FASLG
32 11.89 TP53 MDM2 CDKN1B
33 11.89 TP53 MDM2 E2F2 CDKN1B
34 11.82 TP53 E2F2 CDKN1B
35
Show member pathways
11.82 TP53 MDM2 FASLG E2F2 ATM
36
Show member pathways
11.79 TP53 MDM2 ATM
37 11.76 TP53 STAT1 MDM2
38 11.74 TP53 MDM2 E2F2 CDKN1B
39
Show member pathways
11.71 TP53 MDM2 ATM
40 11.71 E2F2 CDKN1B ATM
41 11.7 TP53 MDM2 E2F2
42
Show member pathways
11.65 TP53 STAT1 E2F2 ATM
43 11.63 TP53 MDM2 ATM
44 11.59 TP53 MDM2 ATM
45 11.55 TP53 MDM2 COPS5
46 11.52 TP53 FASLG E2F2
47 11.5 TP53 CDKN1B ATM
48 11.49 TP53 MDM2 FASLG ATM
49 11.44 TP53 MDM2 ATM
50 11.41 TP53 MDM2 FASLG CDKN1B ATM

GO Terms for Maxillary Sinus Adenocarcinoma

Biological processes related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 TP53 STAT1 MDM2 FASLG E2F2
2 negative regulation of apoptotic process GO:0043066 9.93 TP53 MDM2 COPS5 CDKN1B
3 positive regulation of cell proliferation GO:0008284 9.83 STAT1 SERPINB3 MDM2 FASLG CDKN1B
4 cell cycle arrest GO:0007050 9.77 TP53 CDKN1B ATM
5 heart development GO:0007507 9.76 TP53 MDM2 CDKN1B ATM
6 regulation of signal transduction by p53 class mediator GO:1901796 9.75 TP53 MDM2 ATM
7 response to organic cyclic compound GO:0014070 9.73 STAT1 CYP1A2 CDKN1B
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.72 TP53 STAT1 FASLG
9 regulation of cell proliferation GO:0042127 9.71 TP53 STAT1 CXCL11 CDKN1B
10 cellular response to organic cyclic compound GO:0071407 9.65 STAT1 MDM2 CDKN1B
11 response to antibiotic GO:0046677 9.63 TP53 MDM2
12 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.62 TP53 E2F2
13 negative regulation of proteolysis GO:0045861 9.62 TP53 SERPINB3
14 necroptotic process GO:0070266 9.61 TP53 FASLG
15 positive regulation of protein export from nucleus GO:0046827 9.61 TP53 MDM2
16 determination of adult lifespan GO:0008340 9.6 TP53 ATM
17 mitotic cell cycle arrest GO:0071850 9.58 TP53 CDKN1B
18 regulation of cell cycle GO:0051726 9.56 TP53 E2F2 COPS5 ATM
19 cardiac septum morphogenesis GO:0060411 9.54 TP53 MDM2
20 positive regulation of neuron apoptotic process GO:0043525 9.54 TP53 FASLG ATM
21 replicative senescence GO:0090399 9.52 TP53 ATM
22 cellular response to antibiotic GO:0071236 9.51 MDM2 CDKN1B
23 cellular response to UV-C GO:0071494 9.49 TP53 MDM2
24 response to drug GO:0042493 9.35 TP53 STAT1 MDM2 CYP1A2 CDKN1B
25 cellular response to gamma radiation GO:0071480 9.33 TP53 MDM2 ATM
26 cellular response to actinomycin D GO:0072717 9.32 TP53 MDM2
27 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.92 TP53 MDM2 CDKN1B ATM

Molecular functions related to Maxillary Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone acetyltransferase binding GO:0035035 9.16 TP53 STAT1
2 protein N-terminus binding GO:0047485 9.13 TP53 MDM2 ATM
3 enzyme binding GO:0019899 9.02 TP53 STAT1 MDM2 CYP1A2 COPS5

Sources for Maxillary Sinus Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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