MCID: MXL002
MIFTS: 22

Maxillary Sinus Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Maxillary Sinus Adenoid Cystic Carcinoma

MalaCards integrated aliases for Maxillary Sinus Adenoid Cystic Carcinoma:

Name: Maxillary Sinus Adenoid Cystic Carcinoma 12 15 73
Adenoid Cystic Carcinoma of the Maxillary Sinus 12
Adenoid Cystic Carcinoma of Maxillary Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7198
NCIt 50 C6239
UMLS 73 C1334643

Summaries for Maxillary Sinus Adenoid Cystic Carcinoma

MalaCards based summary : Maxillary Sinus Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of the maxillary sinus, is related to adenoiditis and adenoid cystic carcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Maxillary Sinus Adenoid Cystic Carcinoma is NUMB (NUMB, Endocytic Adaptor Protein), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Maxillary Sinus Adenoid Cystic Carcinoma

Diseases related to Maxillary Sinus Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoiditis 10.3
2 adenoid cystic carcinoma 10.3
3 lung cancer susceptibility 3 10.0
4 adenocarcinoma 10.0
5 ocular melanoma 9.5 IL2 KIT
6 mast cell neoplasm 9.5 IL2 KIT
7 leukocyte disease 9.4 IL2 KIT
8 cell type cancer 9.3 IL2 KIT
9 thymoma 9.2 IL2 KIT
10 hematologic cancer 9.0 IL2 KIT

Graphical network of the top 20 diseases related to Maxillary Sinus Adenoid Cystic Carcinoma:



Diseases related to Maxillary Sinus Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Maxillary Sinus Adenoid Cystic Carcinoma

UMLS symptoms related to Maxillary Sinus Adenoid Cystic Carcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Maxillary Sinus Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.53 KIT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.53 NUMB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.53 NUMB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.53 KIT
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.53 KIT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.53 KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.53 NUMB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.53 NUMB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.53 KIT NUMB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.53 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.53 NUMB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 NUMB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.53 KIT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.53 KIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.53 KIT

Drugs & Therapeutics for Maxillary Sinus Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Maxillary Sinus Adenoid Cystic Carcinoma

Genetic Tests for Maxillary Sinus Adenoid Cystic Carcinoma

Anatomical Context for Maxillary Sinus Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Maxillary Sinus Adenoid Cystic Carcinoma:

41
Lung

Publications for Maxillary Sinus Adenoid Cystic Carcinoma

Articles related to Maxillary Sinus Adenoid Cystic Carcinoma:

# Title Authors Year
1
Chemoradiotherapy for maxillary sinus adenoid cystic carcinoma using superselective intra-arterial infusion via a superficial temporal artery. ( 21953943 )
2013
2
Tumor-to-tumor metastasis: maxillary sinus adenoid cystic carcinoma metastasizing to double primary lung adenocarcinoma. ( 20868783 )
2010

Variations for Maxillary Sinus Adenoid Cystic Carcinoma

Cosmic variations for Maxillary Sinus Adenoid Cystic Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10656 TP53 salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.742C>T p.R248W 17:7674221-7674221 12
2 COSM144147 PPP2R1A salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.773G>A p.R258H 19:52213076-52213076 12
3 COSM1686998 MTOR salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.6644C>T p.S2215F 1:11124516-11124516 12
4 COSM1640831 salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.742C>T p.R248W 17:7674221-7674221 12
5 COSM3388183 salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.742C>T p.R248W 17:7674221-7674221 12
6 COSM120006 salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.463C>T p.R155W 17:7674221-7674221 12
7 COSM120007 salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.742C>T p.R248W 17:7674221-7674221 12
8 COSM120005 salivary gland,maxillary sinus,carcinoma,adenoid cystic carcinoma c.742C>T p.R248W 17:7674221-7674221 12
9 COSM6441198 RB1 upper aerodigestive tract,sinus,carcinoma,undifferentiated carcinoma c.940-1G>A p.? 13:48367493-48367493 8
10 COSM521 KRAS upper aerodigestive tract,sinus,carcinoma,undifferentiated carcinoma c.35G>A p.G12D 12:25245350-25245350 8

Expression for Maxillary Sinus Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Maxillary Sinus Adenoid Cystic Carcinoma.

Pathways for Maxillary Sinus Adenoid Cystic Carcinoma

Pathways related to Maxillary Sinus Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 IL2 KIT
2 10.86 IL2 KIT
3 10.49 IL2 KIT

GO Terms for Maxillary Sinus Adenoid Cystic Carcinoma

Biological processes related to Maxillary Sinus Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.16 KIT NUMB
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.96 IL2 KIT
3 T cell differentiation GO:0030217 8.62 IL2 KIT

Molecular functions related to Maxillary Sinus Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.62 IL2 KIT

Sources for Maxillary Sinus Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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