MCID: MXL004
MIFTS: 28

Maxillary Sinus Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Maxillary Sinus Squamous Cell Carcinoma

MalaCards integrated aliases for Maxillary Sinus Squamous Cell Carcinoma:

Name: Maxillary Sinus Squamous Cell Carcinoma 12 15 70
Epidermoid Carcinoma of the Maxillofacial Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7910
NCIt 50 C6064
UMLS 70 C1334647

Summaries for Maxillary Sinus Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the maxillary sinus.

MalaCards based summary : Maxillary Sinus Squamous Cell Carcinoma, also known as epidermoid carcinoma of the maxillofacial sinus, is related to maxillary sinus cancer and squamous cell carcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Maxillary Sinus Squamous Cell Carcinoma is TAPBP (TAP Binding Protein), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. Affiliated tissues include maxillary sinus and lymph node.

Related Diseases for Maxillary Sinus Squamous Cell Carcinoma

Diseases related to Maxillary Sinus Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 maxillary sinus cancer 28.3 MIR874 MIR654 MIR574 MIR409 MIR299 MIR127
2 squamous cell carcinoma 10.7
3 mucositis 10.3
4 mixed oligodendroglioma-astrocytoma 10.2 TP53 CALR
5 osteonecrosis 10.1
6 myiasis 10.1
7 eating disorder 10.1
8 47,xyy 10.1
9 sinus cancer 10.1
10 wound myiasis 10.1
11 myeloperoxidase deficiency 10.1 CANX CALR
12 uterus carcinoma in situ 10.0 TP53 MIR654
13 cervix uteri carcinoma in situ 10.0 TP53 MIR654
14 pre-malignant neoplasm 9.9 TP53 MIR654 MIR299
15 cervix disease 9.8 TP53 MIR574 MIR127
16 lymphatic system cancer 9.7 TP53 MIR574 MIR127
17 lymphatic system disease 9.7 TP53 MIR574 MIR127
18 colonic disease 9.6 TP53 MIR574 MIR127
19 nemaline myopathy 9.6 MIR409 MIR299 MIR127
20 central nervous system cancer 9.6 TP53 MIR574 MIR409
21 intestinal disease 9.6 TP53 MIR574 MIR127
22 muscular dystrophy, duchenne type 9.6 MIR409 MIR299 MIR127
23 connective tissue disease 9.5 TP53 MIR574 MIR127 CALR
24 connective tissue cancer 9.5 TP53 MIR574 MIR409
25 laryngeal disease 9.5 TP53 MIR654 MIR574 MIR127
26 respiratory system disease 9.4 TP53 MIR574 MIR409 MIR127
27 leukemia, acute myeloid 9.3 TP53 MIR574 MIR127 CALR
28 nervous system disease 9.1 TP53 MIR874 MIR574 MIR409 MIR127
29 paranasal sinus cancer 8.9 TP53 MIR874 MIR654 MIR409 MIR299 MIR127
30 disease of mental health 8.8 TP53 ROBO1 PDIA3 MIR574 MIR409 MIR127

Graphical network of the top 20 diseases related to Maxillary Sinus Squamous Cell Carcinoma:



Diseases related to Maxillary Sinus Squamous Cell Carcinoma

Symptoms & Phenotypes for Maxillary Sinus Squamous Cell Carcinoma

UMLS symptoms related to Maxillary Sinus Squamous Cell Carcinoma:


pain; rhinorrhea

Drugs & Therapeutics for Maxillary Sinus Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Maxillary Sinus Squamous Cell Carcinoma

Genetic Tests for Maxillary Sinus Squamous Cell Carcinoma

Anatomical Context for Maxillary Sinus Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Maxillary Sinus Squamous Cell Carcinoma:

19
Maxillary Sinus

MalaCards organs/tissues related to Maxillary Sinus Squamous Cell Carcinoma:

40
Lymph Node

Publications for Maxillary Sinus Squamous Cell Carcinoma

Articles related to Maxillary Sinus Squamous Cell Carcinoma:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Photosensitizer With Illumination Enhances In Vivo Antitumor Effect of Anti-ROBO1 Immunotoxin on Maxillary Sinus Squamous Cell Carcinoma. 61
32620618 2020
2
A novel technique of arterial blood flow modification in intra-arterial chemoradiotherapy of maxillary sinus squamous cell carcinoma. 61
32604059 2020
3
Retrospective analysis of 98 cases of maxillary sinus squamous cell carcinoma and therapeutic exploration. 61
32375789 2020
4
Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR-204/EphA7 axis. 61
31709597 2020
5
Hyperprogression after one dose of nivolumab in sinonasal cancer: A case report. 61
31058321 2020
6
Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma. 61
32256588 2020
7
Should an elective neck dissection be performed for maxillary sinus squamous cell carcinoma? 61
31418862 2019
8
Radiation with concomitant superselective intra-arterial cisplatin infusion for maxillary sinus squamous cell carcinoma. 61
30915648 2019
9
Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment. 61
30447876 2019
10
Clinical T staging is superior to fluorodeoxyglucose positron emission tomography for predicting local outcomes after intra-arterial infusion chemoradiotherapy for maxillary sinus squamous cell carcinoma. 61
30587868 2018
11
The role of elective neck dissection in the treatment of maxillary sinus squamous cell carcinoma. 61
29193120 2018
12
Carcinoma of the Maxillary Antrum: A Case Report. 61
30027006 2018
13
Successful salvage treatment of refractory recurrence of maxillary sinus carcinoma using image-guided high-dose-rate interstitial brachytherapy. 61
29789765 2018
14
Recurrent maxillary sinus cancer with only adrenal metastasis. 61
29181177 2017
15
Maxillary reconstruction with a double-barrel osteocutaneous fibular flap and arteriovenous saphenous loop after a globe-sparing total maxillectomy-A Case Report. 61
26081344 2017
16
[The comparative analysis of hypothermia plasma ablation and conventional resection method in endoscopic transnasal surgery for squamous-cell carcinoma in pterygopalatine fossa]. 61
29797928 2016
17
A Case of Extensive Wound Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in a Patient with Maxillary Sinus Squamous Cell Carcinoma, in Turkey. 61
27308285 2016
18
A Clinical Study of Maxillary Sinus Squamous Cell Carcinoma. 61
27115153 2016
19
Lymph node metastasis in t4 maxillary sinus squamous cell carcinoma: incidence and treatment outcome. 61
24554063 2014
20
Squamous cell carcinoma at maxillary sinus: clinicopathologic data in a single Brazilian institution with review of literature. 61
25674251 2014
21
Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma. 61
23558898 2013
22
MicroRNAs function as tumor suppressors or oncogenes: aberrant expression of microRNAs in head and neck squamous cell carcinoma. 61
22831895 2013
23
An update on squamous carcinoma of the oral cavity, oropharynx, and maxillary sinus. 61
22341511 2012
24
Maxillary sinus squamous cell carcinoma with concurrent prolonged foreign body impaction. 61
22446444 2012
25
Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. 61
21922130 2012
26
Neoadjuvant chemoradiation in squamous cell carcinoma of the maxillary sinus: a 26-year experience. 61
23056940 2012
27
Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma. 61
21701775 2011
28
Radiotherapy with or without surgery for maxillary sinus squamous cell carcinoma: should the clinical N0 neck be treated? 61
21150568 2011
29
Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. 61
21847129 2011
30
Advanced maxillary sinus cancer treated with concurrent chemoradiotherapy with intra-arterial cisplatin/docetaxel and oral s-1: own experience and literature review. 61
22114575 2011
31
Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). 61
21753766 2011
32
Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma. 61
21035287 2011
33
[Clinical analysis of 60 cases with maxillary squamous cell carcinoma]. 61
21055053 2010
34
Malignant hypercalcemia in a patient with maxillary sinus squamous cell carcinoma without skeletal metastases. 61
21457634 2010
35
Maxillary Sinus Squamous Cell Carcinoma Presenting with Fatal Tumor Lysis Syndrome: A Case Report and Review of the Literature. 61
20737042 2009
36
The efficacy and safety of concurrent chemoradiotherapy for maxillary sinus squamous cell carcinoma patients. 61
19097833 2009
37
[Treatment of advanced maxillary sinus squamous carcinoma: an analysis of 92 cases]. 61
18479606 2008
38
Lymph node metastases in malignant tumors of the paranasal sinuses: prognostic value and treatment. 61
18283160 2008
39
[Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma]. 61
16219146 2005
40
Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma. 61
16012042 2005
41
Surgical outcome of radical maxillectomy in advanced maxillary sinus cancers. 61
15344202 2004
42
VEGF and bFGF expression and microvessel density of maxillary sinus squamous cell carcinoma in relation to p53 status, spontaneous apoptosis and prognosis. 61
15142681 2004
43
[A case of a 91-year-old woman with maxillary sinus carcinoma who achieved a complete response to chemoradiotherapy with intra-arterial administration of docetaxel]. 61
14650963 2003
44
Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients. 61
14519625 2003
45
[Results of combined therapy for maxillary sinus squamous cell carcinoma]. 61
12934550 2003
46
State of mastication affects quality of life in patients with maxillary sinus cancer. 61
12671436 2003
47
Artifactual 2-deoxy-2-[(18)F]fluoro-D-glucose localization surrounding metallic objects in a PET/CT scanner using CT-based attenuation correction. 61
14499157 2003
48
[Statistical analysis of maxillary sinus squamous cell carcinoma]. 61
12138701 2002
49
Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma. 61
11932899 2002
50
Treatment outcome of maxillary sinus squamous cell carcinoma. 61
11745227 2001

Variations for Maxillary Sinus Squamous Cell Carcinoma

Expression for Maxillary Sinus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Maxillary Sinus Squamous Cell Carcinoma.

Pathways for Maxillary Sinus Squamous Cell Carcinoma

Pathways related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 TP53 TAPBP PDIA3 CALR
2
Show member pathways
12.48 TAPBP PDIA3 CANX CALR
3
Show member pathways
12.47 TP53 TAPBP PDIA3 CALR
4 12.37 TP53 TAPBP PDIA3 CALR
5 11.99 TP53 CANX CALR
6
Show member pathways
11.9 TAPBP PDIA3 CANX CALR
7 11.81 PDIA3 CANX CALR
8 11.67 TP53 MIR874 MIR127
9
Show member pathways
11.36 PDIA3 CANX CALR
10 10.32 TAPBP PDIA3 CANX CALR
11
Show member pathways
9.56 CANX CALR

GO Terms for Maxillary Sinus Squamous Cell Carcinoma

Cellular components related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 PDIA3 MIR874 MIR654 MIR574 MIR409 MIR127
2 endoplasmic reticulum quality control compartment GO:0044322 9.37 CANX CALR
3 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.33 TAPBP ROBO1 CALR
4 smooth endoplasmic reticulum GO:0005790 9.32 CANX CALR
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 TAPBP CANX CALR
6 MHC class I peptide loading complex GO:0042824 8.8 TAPBP PDIA3 CALR

Biological processes related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.63 MIR874 MIR654 MIR574 MIR409 MIR299 MIR127
2 protein folding GO:0006457 9.54 PDIA3 CANX CALR
3 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.5 TAPBP PDIA3 CALR
4 endoplasmic reticulum unfolded protein response GO:0030968 9.4 CANX CALR
5 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.26 TAPBP CALR
6 protein folding in endoplasmic reticulum GO:0034975 9.13 PDIA3 CANX CALR
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.92 TAPBP PDIA3 CANX CALR

Molecular functions related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.13 MIR654 MIR409 MIR299
2 unfolded protein binding GO:0051082 8.8 TAPBP CANX CALR

Sources for Maxillary Sinus Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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