MCID: MXL004
MIFTS: 27

Maxillary Sinus Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Maxillary Sinus Squamous Cell Carcinoma

MalaCards integrated aliases for Maxillary Sinus Squamous Cell Carcinoma:

Name: Maxillary Sinus Squamous Cell Carcinoma 12 15 73
Epidermoid Carcinoma of the Maxillofacial Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7910
NCIt 50 C6064
UMLS 73 C1334647

Summaries for Maxillary Sinus Squamous Cell Carcinoma

MalaCards based summary : Maxillary Sinus Squamous Cell Carcinoma, also known as epidermoid carcinoma of the maxillofacial sinus, is related to squamous cell carcinoma and lactate dehydrogenase b deficiency, and has symptoms including pain and rhinorrhea. An important gene associated with Maxillary Sinus Squamous Cell Carcinoma is TAPBP (TAP Binding Protein), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include lymph node.

Related Diseases for Maxillary Sinus Squamous Cell Carcinoma

Diseases related to Maxillary Sinus Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.6
2 lactate dehydrogenase b deficiency 9.9
3 myiasis 9.9
4 wound myiasis 9.9
5 paranasal sinus cancer 9.8 PDIA3 TAPBP
6 maxillary sinus cancer 9.7 PDIA3 TAPBP
7 essential thrombocythemia 9.7 CALR TP53
8 orbital melanoma 9.6 CANX TAPBP
9 myeloperoxidase deficiency 9.4 CALR CANX
10 suppurative cholangitis 9.3 CANX TAPBP
11 long qt syndrome 9.0 CALR CANX

Graphical network of the top 20 diseases related to Maxillary Sinus Squamous Cell Carcinoma:



Diseases related to Maxillary Sinus Squamous Cell Carcinoma

Symptoms & Phenotypes for Maxillary Sinus Squamous Cell Carcinoma

UMLS symptoms related to Maxillary Sinus Squamous Cell Carcinoma:


pain, rhinorrhea

Drugs & Therapeutics for Maxillary Sinus Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Maxillary Sinus Squamous Cell Carcinoma

Genetic Tests for Maxillary Sinus Squamous Cell Carcinoma

Anatomical Context for Maxillary Sinus Squamous Cell Carcinoma

MalaCards organs/tissues related to Maxillary Sinus Squamous Cell Carcinoma:

41
Lymph Node

Publications for Maxillary Sinus Squamous Cell Carcinoma

Articles related to Maxillary Sinus Squamous Cell Carcinoma:

(show all 21)
# Title Authors Year
1
The role of elective neck dissection in the treatment of maxillary sinus squamous cell carcinoma. ( 29193120 )
2017
2
A Case of Extensive Wound Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in a Patient with Maxillary Sinus Squamous Cell Carcinoma, in Turkey. ( 27308285 )
2016
3
A Clinical Study of Maxillary Sinus Squamous Cell Carcinoma. ( 27115153 )
2016
4
Lymph node metastasis in t4 maxillary sinus squamous cell carcinoma: incidence and treatment outcome. ( 24554063 )
2014
5
Maxillary sinus squamous cell carcinoma with concurrent prolonged foreign body impaction. ( 22446444 )
2012
6
Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. ( 21922130 )
2012
7
Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma. ( 21701775 )
2011
8
Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. ( 21847129 )
2011
9
Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma. ( 21035287 )
2011
10
Radiotherapy with or without surgery for maxillary sinus squamous cell carcinoma: should the clinical N0 neck be treated? ( 21150568 )
2011
11
Malignant hypercalcemia in a patient with maxillary sinus squamous cell carcinoma without skeletal metastases. ( 21457634 )
2010
12
Maxillary Sinus Squamous Cell Carcinoma Presenting with Fatal Tumor Lysis Syndrome: A Case Report and Review of the Literature. ( 20737042 )
2009
13
The efficacy and safety of concurrent chemoradiotherapy for maxillary sinus squamous cell carcinoma patients. ( 19097833 )
2009
14
[Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma]. ( 16219146 )
2005
15
Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma. ( 16012042 )
2005
16
VEGF and bFGF expression and microvessel density of maxillary sinus squamous cell carcinoma in relation to p53 status, spontaneous apoptosis and prognosis. ( 15142681 )
2004
17
Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients. ( 14519625 )
2003
18
Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma. ( 11932899 )
2002
19
Treatment outcome of maxillary sinus squamous cell carcinoma. ( 11745227 )
2001
20
A correlation of argyrophilic nucleolar organizer regions with prognoses in patients with maxillary sinus squamous cell carcinoma. ( 7522478 )
1994
21
Nucleolar organizer regions in human maxillary sinus squamous cell carcinoma. ( 8465651 )
1993

Variations for Maxillary Sinus Squamous Cell Carcinoma

Cosmic variations for Maxillary Sinus Squamous Cell Carcinoma:

9
(show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1610880 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 8
2 COSM10704 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 8
3 COSM44097 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.530C>T p.P177L 17:7675082-7675082 8
4 COSM43555 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.736A>G p.M246V 17:7674227-7674227 8
5 COSM10660 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 8
6 COSM43962 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.805A>G p.S269G 17:7673815-7673815 8
7 COSM10648 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 8
8 COSM43881 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.757A>T p.T253S 17:7674206-7674206 8
9 COSM10659 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 8
10 COSM44338 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.845G>A p.R282Q 17:7673775-7673775 8
11 COSM45046 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.542G>C p.R181P 17:7675070-7675070 8
12 COSM10647 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 8
13 COSM10654 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 8
14 COSM10651 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.530C>G p.P177R 17:7675082-7675082 8
15 COSM27173 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 8
16 COSM44312 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.511G>A p.E171K 17:7675101-7675101 8
17 COSM10656 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 8
18 COSM10650 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.529C>T p.P177S 17:7675083-7675083 8
19 COSM4531793 SUZ12 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.1825G>A p.G609R 17:31996828-31996828 8
20 COSM6973197 SUZ12 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.1639G>C p.E547Q 17:31995607-31995607 8
21 COSM6973188 NSD1 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.5074C>G p.H1692D 5:177260096-177260096 8
22 COSM581 NRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.181C>G p.Q61E 1:114713909-114713909 8
23 COSM6973198 NOTCH3 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2641G>A p.G881S 19:15181727-15181727 8
24 COSM6973185 NOTCH2 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.5458G>C p.D1820H 1:119920250-119920250 8
25 COSM120958 NFE2L2 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.235G>C p.E79Q 2:177234082-177234082 8
26 COSM6973195 LATS2 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2827G>C p.E943Q 13:20975310-20975310 8
27 COSM551 KRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.182A>C p.Q61P 12:25227342-25227342 8
28 COSM518 KRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.34G>C p.G12R 12:25245351-25245351 8
29 COSM487 HRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 8
30 COSM500 HRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.182A>C p.Q61P 11:533874-533874 8
31 COSM6973196 GRIN2A upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2008T>A p.F670I 16:9822424-9822424 8
32 COSM6960306 ETV1 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.755C>G p.P252R 7:13931549-13931549 8
33 COSM6960303 EPHA3 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2945C>T p.P982L 3:89479495-89479495 8
34 COSM6942122 CDK12 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2045C>T p.P682L 17:39490670-39490670 8
35 COSM5967148 ARID1A upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.3446C>G p.S1149* 1:26772539-26772539 8
36 COSM2744987 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 8
37 COSM3937615 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 8
38 COSM1610881 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 8
39 COSM1610882 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 8
40 COSM3717684 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 8
41 COSM2744988 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 8
42 COSM3717685 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 8
43 COSM6973194 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2827G>C p.E943Q 13:20975310-20975310 8
44 COSM6960305 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.635C>G p.P212R 7:13931549-13931549 8
45 COSM6973189 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.5074C>G p.H1692D 5:177260096-177260096 8
46 COSM2744989 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 8
47 COSM6973199 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2641G>A p.G881S 19:15181727-15181727 8
48 COSM6441198 RB1 upper aerodigestive tract,sinus,carcinoma,undifferentiated carcinoma c.940-1G>A p.? 13:48367493-48367493 6
49 COSM521 KRAS upper aerodigestive tract,sinus,carcinoma,undifferentiated carcinoma c.35G>A p.G12D 12:25245350-25245350 6

Expression for Maxillary Sinus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Maxillary Sinus Squamous Cell Carcinoma.

Pathways for Maxillary Sinus Squamous Cell Carcinoma

Pathways related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CALR CANX PDIA3 TAPBP TP53
2
Show member pathways
12.9 CALR CANX PDIA3 TAPBP TP53
3
Show member pathways
12.54 CALR CANX PDIA3
4
Show member pathways
12.41 CALR CANX PDIA3 TAPBP
5 12.02 CALR CANX TP53
6 11.8 CALR CANX PDIA3
7
Show member pathways
11.7 CALR CANX PDIA3 TAPBP
8 11.68 CALR CANX
9
Show member pathways
11.36 CALR CANX PDIA3
10 10.32 CALR CANX PDIA3 TAPBP
11
Show member pathways
9.76 CALR CANX

GO Terms for Maxillary Sinus Squamous Cell Carcinoma

Cellular components related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.55 CALR CANX PDIA3 TAPBP TP53
2 endoplasmic reticulum lumen GO:0005788 9.54 CALR CANX PDIA3
3 myelin sheath GO:0043209 9.48 CANX PDIA3
4 melanosome GO:0042470 9.46 CANX PDIA3
5 phagocytic vesicle membrane GO:0030670 9.43 CALR TAPBP
6 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.4 CALR TAPBP
7 endoplasmic reticulum quality control compartment GO:0044322 9.32 CALR CANX
8 smooth endoplasmic reticulum GO:0005790 9.26 CALR CANX
9 MHC class I peptide loading complex GO:0042824 8.96 CALR TAPBP
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 CALR CANX TAPBP

Biological processes related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein folding GO:0006457 9.5 CALR CANX PDIA3
2 protein-containing complex assembly GO:0065003 9.4 TAPBP TP53
3 chaperone-mediated protein folding GO:0061077 9.37 CALR CANX
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.33 CALR PDIA3 TAPBP
5 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.26 CALR TAPBP
6 protein folding in endoplasmic reticulum GO:0034975 9.13 CALR CANX PDIA3
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.92 CALR CANX PDIA3 TAPBP

Molecular functions related to Maxillary Sinus Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.96 CALR TP53
2 unfolded protein binding GO:0051082 8.8 CALR CANX TAPBP

Sources for Maxillary Sinus Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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