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MCID: MXL015
MIFTS: 39

Maxillary Sinusitis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Maxillary Sinusitis

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MalaCards integrated aliases for Maxillary Sinusitis:

Name: Maxillary Sinusitis 12 45 15 17 74

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2051
MeSH 45 D015523
NCIt 51 C34809
SNOMED-CT 69 88348008
ICD10 34 J32.0
UMLS 74 C0024959
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Summaries for Maxillary Sinusitis

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Disease Ontology : 12 A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.

MalaCards based summary : Maxillary Sinusitis is related to chronic maxillary sinusitis and rhinitis. An important gene associated with Maxillary Sinusitis is IRAK4 (Interleukin 1 Receptor Associated Kinase 4), and among its related pathways/superpathways are NF-kappaB Signaling and amb2 Integrin signaling. The drugs Ethinyl Estradiol and Norgestimate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and tonsil.

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Related Diseases for Maxillary Sinusitis

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Diseases in the Maxillary Sinusitis family:

Chronic Maxillary Sinusitis Acute Maxillary Sinusitis

Diseases related to Maxillary Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 chronic maxillary sinusitis 33.8 MPO RHNO1 RNASE3
2 rhinitis 30.2 CCL5 RNASE3
3 bronchitis 29.7 MPO RNASE3
4 common cold 29.6 CCL5 RNASE3 SELP
5 asthma 29.5 CCL5 MPO RNASE3 SELP
6 acute maxillary sinusitis 12.8
7 sinusitis 11.8
8 paranasal sinus disease 11.2
9 cystic fibrosis 10.2
10 immune-complex glomerulonephritis 10.2 MPO SELP
11 headache 10.2
12 chronic conjunctivitis 10.1 CCL5 RNASE3
13 status asthmaticus 10.1 CCL5 RNASE3
14 collagenous colitis 10.1 MPO RNASE3
15 chronic eosinophilic pneumonia 10.1 CCL5 RNASE3
16 eosinophilic pneumonia 10.1 CCL5 RNASE3
17 kimura disease 10.1 CCL5 RNASE3
18 henoch-schoenlein purpura 10.1 MPO RNASE3
19 otitis media 10.1
20 osteonecrosis 10.1
21 enophthalmos 10.1
22 pneumonia 10.1
23 odontoma 10.1
24 vernal keratoconjunctivitis 10.1 CCL5 RNASE3
25 proctitis 10.1 MPO RNASE3
26 vernal conjunctivitis 10.1 MPO RNASE3
27 extrinsic allergic alveolitis 10.1 CCL5 MPO
28 churg-strauss syndrome 10.1 MPO RNASE3
29 pulmonary eosinophilia 10.1 CCL5 RNASE3
30 onchocerciasis 10.0 CCL5 RNASE3
31 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.0
32 lymphoma 10.0
33 osteomyelitis 10.0
34 endocarditis 10.0
35 orbital cellulitis 10.0
36 cellulitis 10.0
37 cluster headache 10.0
38 chronic rhinitis 10.0 MPO RHNO1
39 bronchial disease 10.0 CCL5 RNASE3
40 bronchiolitis 10.0 CCL5 RNASE3
41 respiratory system disease 9.9 CCL5 MPO RNASE3
42 pulmonary disease, chronic obstructive 9.9 CCL5 MPO RNASE3
43 lung disease 9.9 CCL5 MPO RNASE3
44 burkitt lymphoma 9.9
45 cleidocranial dysplasia 9.9
46 chondrosarcoma 9.9
47 3-methylglutaconic aciduria, type iii 9.9
48 basal cell carcinoma 1 9.9
49 beta-thalassemia 9.9
50 aspergillosis 9.9

Graphical network of the top 20 diseases related to Maxillary Sinusitis:



Diseases related to Maxillary Sinusitis
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Symptoms & Phenotypes for Maxillary Sinusitis

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Drugs & Therapeutics for Maxillary Sinusitis

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Drugs for Maxillary Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
2
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
5
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
6
Clarithromycin Approved Phase 4 81103-11-9 84029
7
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 441411 12560
8
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
9
Telithromycin Approved Phase 4,Phase 3 191114-48-4 70789201 5462516
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2
11 Contraceptives, Oral, Combined Phase 4
12 Contraceptives, Oral Phase 4
13 Topoisomerase Inhibitors Phase 4,Phase 3
14 Contraceptive Agents Phase 4
15 Estradiol 3-benzoate Phase 4
16 Estradiol 17 beta-cypionate Phase 4
17 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
18 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
19 Antibiotics, Antitubercular Phase 4
20 Erythromycin Ethylsuccinate Phase 4
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
22 Erythromycin Estolate Phase 4
23 Antitubercular Agents Phase 4
24 Cytochrome P-450 CYP3A Inhibitors Phase 4
25 Erythromycin stearate Phase 4
26
Ofloxacin Approved Phase 3 82419-36-1 4583
27
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
28
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
29 Anti-Infective Agents, Urinary Phase 3
30 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
31 Renal Agents Phase 3
32 Amoxicillin-Potassium Clavulanate Combination Phase 3
33 beta-Lactamase Inhibitors Phase 3
34 Clavulanic Acids Phase 3
35
Pseudoephedrine Approved Phase 2 90-82-4 7028
36
Ephedrine Approved Phase 2 299-42-3 9294
37 Vasoconstrictor Agents Phase 2
38 Sympathomimetics Phase 2
39 Autonomic Agents Phase 2
40 Adrenergic Agents Phase 2
41 Nasal Decongestants Phase 2
42 Peripheral Nervous System Agents Phase 2
43 Neurotransmitter Agents Phase 2
44 Central Nervous System Stimulants Phase 2
45 Bronchodilator Agents Phase 2
46 Respiratory System Agents Phase 2
47 Anti-Asthmatic Agents Phase 2
48
Xylometazoline Approved, Investigational 526-36-3 5709

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
2 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
3 Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
4 A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days. Completed NCT00236652 Phase 3 levofloxacin
5 A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults Completed NCT00643409 Phase 3 azithromycin SR (Zithromax; compound: CP-62,993);levofloxacin
6 AMS VS MOXI Ketek vs Avelox in AMS Completed NCT00537563 Phase 3 Telithromycin
7 A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses Completed NCT00249210 Phase 3 levofloxacin
8 Preventing Frequent Sinus Infections in HIV-Infected Patients Withdrawn NCT00000752 Phase 2 Pseudoephedrine hydrochloride;Guaifenesin;Cefuroxime axetil;Beclomethasone dipropionate
9 Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis Unknown status NCT03083392 Not Applicable
10 Acute Upper Respiratory Tract Infection - When is Bacteria Involved? Unknown status NCT01580137
11 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis Completed NCT01032174 Azithromycin SR;Amoxiclav 1000 mg
12 Levofloxacin in Bacterial Rhinosinussitis Completed NCT02712502 Levofloxacin;Amoxicillin-Potassium Clavulanate Combination
13 Postoperative Treatment After Endoscopic Sinus Surgery Completed NCT00534768 Not Applicable
14 Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis Active, not recruiting NCT00683371 Not Applicable
15 Study Designed to Clinically Evaluate Sinus Wash Device Prototypes Not yet recruiting NCT02931604 Not Applicable
16 Zygomatic Versus Conventional Dental Implants in Augmented Maxillae Withdrawn NCT01961284 Not Applicable

Search NIH Clinical Center for Maxillary Sinusitis

Cochrane evidence based reviews: maxillary sinusitis

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Genetic Tests for Maxillary Sinusitis

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Anatomical Context for Maxillary Sinusitis

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MalaCards organs/tissues related to Maxillary Sinusitis:

42
Eye, Bone, Tonsil, Testes, Skin, Colon, Lung
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Publications for Maxillary Sinusitis

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Articles related to Maxillary Sinusitis:

(show top 50) (show all 607)
# Title Authors Year
1
Long-Term Effectiveness of Balloon Catheter Sinuplasty in Pediatric Chronic Maxillary Sinusitis. ( 30943802 )
2019
2
Characteristics of Chronic Maxillary Sinusitis in Patients With a History of Long-term Bisphosphonate Use. ( 31041868 )
2019
3
Deep Learning in Diagnosis of Maxillary Sinusitis Using Conventional Radiography. ( 30067607 )
2019
4
Is post orthognathic maxillary sinusitis related to sino-nasal anatomical alterations? ( 30935854 )
2019
5
Definition and management of odontogenic maxillary sinusitis. ( 30989083 )
2019
6
Evaluation of Odontogenic Maxillary Sinusitis with Cone Beam Computed Tomography: A Retrospective Study with Review of Literature. ( 31058071 )
2019
7
Correlation between prevelance of Haller cells and postoperative maxillary sinusitis after sinus lifting Procedure. ( 31085018 )
2019
8
Subdural empyema as a complication of odontogenic maxillary sinusitis. ( 28843931 )
2018
9
A Case of Fungus Ball-Type Maxillary Sinusitis Due to Penicillium Roqueforti. ( 29075960 )
2018
10
Clinical implications of taste thresholds in patients with odontogenic maxillary sinusitis. ( 29174862 )
2018
11
ACTUAL ISSUES OF ODONTOGENIC MAXILLARY SINUSITIS (REVIEW). ( 29697380 )
2018
12
Efficacy of sinus ultrasound in diagnosis of acute and subacute maxillary sinusitis. ( 29779998 )
2018
13
Treatment options for odontogenic maxillary sinusitis: a review. ( 29806655 )
2018
14
Is dental evaluation considered in unilateral maxillary sinusitis? A retrospective case series. ( 30045653 )
2018
15
Maxillary sinusitis complicated by stroke. ( 30072286 )
2018
16
A new ultrasound sign in the diagnosis of pediatric maxillary sinusitis. ( 30159267 )
2018
17
Deep-learning classification using convolutional neural network for evaluation of maxillary sinusitis on panoramic radiography. ( 30539342 )
2018
18
Root Cause Analysis: An Examination of Odontogenic Origins of Acute Maxillary Sinusitis in Both Immunocompetent & Immunocompromised Patients. ( 27798445 )
2017
19
Haemophilus parainfluenzae Endocarditis Associated With Maxillary Sinusitis and Complicated by Cerebral Emboli in a Young Man. ( 28491883 )
2017
20
Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst. ( 27422628 )
2017
21
Nasal Septal Deviation and Concha Bullosa - Do They Have an Impact on Maxillary Sinus Volumes and Prevalence of Maxillary Sinusitis? ( 28348652 )
2017
22
Novel approach to the maxillary sinusitis after sinus graft. ( 28695114 )
2017
23
Clinical efficacy of main radiological diagnostic methods for odontogenic maxillary sinusitis. ( 28733779 )
2017
24
Unusual case of odontogenic maxillary sinusitis. ( 28747419 )
2017
25
Role of Sinonasal Anatomic Variations in the Development of Maxillary Sinusitis: A Cone Beam CT Analysis. ( 28839485 )
2017
26
When Maxillary Sinusitis Does Not Heal: Findings on CBCT Scans of the Sinuses With a Particular Focus on the Occurrence of Odontogenic Causes of Maxillary Sinusitis. ( 29299521 )
2017
27
Are Antibiotics Effective in the Treatment of Acute Maxillary Sinusitis? ( 26498508 )
2016
28
Management of acute maxillary sinusitis after sinus bone grafting procedures with simultaneous dental implants placement - a retrospective study. ( 27169511 )
2016
29
One stage combined endoscopic and per-oral buccal fat pad approach for large oro-antral-fistula closure with secondary chronic maxillary sinusitis. ( 26006724 )
2016
30
Radiological and clinical difficulties in the management of chronic maxillary sinusitis in β Thalassemic paediatric patients. ( 27063757 )
2016
31
Chronic Maxillary Sinusitis Caused by Denture Lining Material. ( 27386012 )
2016
32
Prevalence of chronic maxillary sinusitis in children from rural and urban skeletal populations in Poland. ( 29539544 )
2016
33
Haemophilus parainfluenzae endocarditis with systemic embolisation following maxillary sinusitis. ( 27599807 )
2016
34
A 44-Year-Old Man with Waldenstrom Macroglobulinemia and Bilateral Maxillary Sinusitis. ( 27840358 )
2016
35
Is Le Fort I Osteotomy Associated With Maxillary Sinusitis? ( 26546843 )
2016
36
Utilization of computer-aided detection system in diagnosing unilateral maxillary sinusitis on panoramic radiographs. ( 26837670 )
2016
37
Are Zygomatic Implants Associated With Maxillary Sinusitis? ( 27070844 )
2016
38
Metastatic mammary carcinoma to the orbit masquerading as maxillary sinusitis. ( 27103558 )
2016
39
Salmonella enterica Subspecies diarizonae Maxillary Sinusitis in a Snake Handler: First Report. ( 27186588 )
2016
40
Near-Infrared Optical Imaging for Diagnosis of Maxillary Sinusitis. ( 27329417 )
2016
41
WITHDRAWN: Antibiotics for acute maxillary sinusitis in adults. ( 26471061 )
2015
42
Long-term outcomes of endoscopic maxillary mega-antrostomy for refractory chronic maxillary sinusitis. ( 25312656 )
2015
43
[The role of accessory ostia of the maxillary sinuses in pathogenesis of acute and chronic maxillary sinusitis]. ( 26640843 )
2015
44
Intra-oral low level laser therapy in chronic maxillary sinusitis: A new and effective recommended technique. ( 26644829 )
2015
45
Chronic maxillary sinusitis and diabetes related maxillary osteonecrosis: a case report. ( 26734561 )
2015
46
Endonasal endoscopic surgery with combined middle and inferior meatal antrostomies for fungal maxillary sinusitis. ( 25706162 )
2015
47
IRAK4 gene polymorphism and odontogenic maxillary sinusitis. ( 25707370 )
2015
48
Distinguishing the dominant species of pathogen in maxillary sinusitis by sequencing DNA dataset analysis. ( 25724392 )
2015
49
Large Haller cell mucocele leading to maxillary sinusitis. ( 25923288 )
2015
50
Maxillary sinusitis diagnosed by ultrasound. ( 25952933 )
2015
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Variations for Maxillary Sinusitis

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Expression for Maxillary Sinusitis

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Search GEO for disease gene expression data for Maxillary Sinusitis.
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Pathways for Maxillary Sinusitis

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Pathways related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.65 CCL5 IRAK4 MPO
2
amb2 Integrin signaling 1
10.3 MPO SELP
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GO Terms for Maxillary Sinusitis

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Cellular components related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL5 IRAK4 MPO RNASE3 SELP
2 azurophil granule lumen GO:0035578 8.96 MPO RNASE3

Biological processes related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.26 RNASE3 SELP
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.16 CCL5 SELP
3 positive regulation of smooth muscle cell proliferation GO:0048661 8.96 CCL5 IRAK4
4 leukocyte cell-cell adhesion GO:0007159 8.62 CCL5 SELP

Molecular functions related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 RNASE3 SELP
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Sources for Maxillary Sinusitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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