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MCID: MXL015
MIFTS: 38

Maxillary Sinusitis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Maxillary Sinusitis

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MalaCards integrated aliases for Maxillary Sinusitis:

Name: Maxillary Sinusitis 12 44 15 17 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2051
MeSH 44 D015523
NCIt 50 C34809
SNOMED-CT 67 275484005
ICD10 32 J32.0
UMLS 71 C0024959
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Summaries for Maxillary Sinusitis

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Disease Ontology : 12 A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.

MalaCards based summary : Maxillary Sinusitis is related to chronic maxillary sinusitis and allergic rhinitis. An important gene associated with Maxillary Sinusitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and Folate Metabolism. The drugs Hyaluronic acid and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain, and related phenotype is immune system.

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Related Diseases for Maxillary Sinusitis

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Diseases in the Maxillary Sinusitis family:

Chronic Maxillary Sinusitis Acute Maxillary Sinusitis

Diseases related to Maxillary Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 chronic maxillary sinusitis 32.7 RNASE3 PDPN MPO IRAK4
2 allergic rhinitis 30.6 RNASE3 MPO CCL5
3 ethmoid sinusitis 30.6 PRTN3 CRP
4 bronchopneumonia 30.5 MPO CRP
5 cellulitis 30.4 RNASE3 LACTB CRP
6 frontal sinusitis 30.4 PRTN3 CRP
7 common cold 30.3 SELP RNASE3 CCL5
8 hypereosinophilic syndrome 30.3 RNASE3 MPO CCL5
9 acute frontal sinusitis 30.2 PRTN3 MPO
10 facial paralysis 29.9 PRTN3 CRP
11 meningitis 29.8 LACTB IRAK4 CRP CCL5
12 bronchitis 29.7 RNASE3 MPO LACTB CRP CCL5
13 otitis media 29.7 RNASE3 MUC5B MPO LACTB CRP
14 disease by infectious agent 29.5 PRTN3 LACTB IRAK4 CRP
15 middle ear disease 29.4 PRTN3 MUC5B MPO CRP
16 proteasome-associated autoinflammatory syndrome 1 29.3 SELP RNASE3 MPO CRP CCL5
17 lung disease 29.1 RNASE3 PRTN3 MUC5B MPO CRP CCL5
18 cystic fibrosis 29.0 RNASE3 PRTN3 MUC5B MPO LACTB CRP
19 acute maxillary sinusitis 11.7
20 haemophilus influenzae 10.8
21 rhinitis 10.5
22 pleural empyema 10.4
23 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.4
24 periodontitis 10.4
25 anaerobic pneumonia 10.3 MPO CCL5
26 adhesive otitis media 10.3 RNASE3 MPO
27 vernal conjunctivitis 10.3 RNASE3 MPO
28 aspergillosis 10.3
29 osteomyelitis 10.3
30 headache 10.3
31 chronic rhinitis 10.3 RNASE3 MPO
32 vernal keratoconjunctivitis 10.3 RNASE3 CCL5
33 allergic cutaneous vasculitis 10.3 PRTN3 MPO
34 enophthalmos 10.2
35 orbital cellulitis 10.2
36 suppurative periapical periodontitis 10.2
37 anca-associated vasculitis 10.2 PRTN3 MPO
38 pulmonary hemosiderosis 10.2 PRTN3 MPO
39 collagenous colitis 10.2 RNASE3 MPO
40 anti-basement membrane glomerulonephritis 10.2 PRTN3 MPO
41 chronic eosinophilic pneumonia 10.2 RNASE3 CCL5
42 osteonecrosis 10.2
43 odontoma 10.2
44 viral laryngitis 10.2 RNASE3 CRP
45 marginal corneal ulcer 10.2 MPO CRP
46 dacryocystocele 10.2 PRTN3 PDPN
47 chronic inflammation of lacrimal passage 10.2 PRTN3 PDPN
48 status asthmaticus 10.2 RNASE3 CCL5
49 patulous eustachian tube 10.2 RNASE3 MPO CCL5
50 pollen allergy 10.2 RNASE3 MPO

Graphical network of the top 20 diseases related to Maxillary Sinusitis:



Diseases related to Maxillary Sinusitis
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Symptoms & Phenotypes for Maxillary Sinusitis

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MGI Mouse Phenotypes related to Maxillary Sinusitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL5 CRP IRAK4 MPO MUC5B PDPN
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Drugs & Therapeutics for Maxillary Sinusitis

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Drugs for Maxillary Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
5
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
6
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
7
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Azithromycin Approved Phase 4 83905-01-5 55185 447043
10
Telithromycin Approved Phase 4 191114-48-4 5462516 70789201
11 Protective Agents Phase 4
12 Viscosupplements Phase 4
13 Immunologic Factors Phase 4
14 Adjuvants, Immunologic Phase 4
15 Erythromycin Estolate Phase 4
16 Erythromycin stearate Phase 4
17 Erythromycin Ethylsuccinate Phase 4
18 Contraceptives, Oral Phase 4
19 Contraceptive Agents Phase 4
20 Estradiol 3-benzoate Phase 4
21 Estradiol 17 beta-cypionate Phase 4
22 Contraceptives, Oral, Combined Phase 4
23 Norgestimate, ethinyl estradiol drug combination Phase 4
24 Antibiotics, Antitubercular Phase 4
25 Anti-Infective Agents Phase 4
26 Anti-Bacterial Agents Phase 4
27
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
28
Ofloxacin Approved Phase 3 82419-36-1 4583
29
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
30
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32
Oxymetazoline Approved, Investigational 1491-59-4 4636
33
Phenylephrine Approved 59-42-7 6041
34 Hemostatics
35 Analgesics

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Maxillary Sinus Augmentation With Three Different Biomaterials: Histologic, Histomorphometric, Clinical and Patient Reported Outcomes From a Randomized Controlled Trial Completed NCT04506827 Phase 4
2 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
3 Prospective, Multicenter, Open, Uncontrolled Trial to Evaluate the Time to Bacterial Eradication and Key Symptom Relief in the Treatment of Acute Bacterial Maxillary Sinusitis With Moxifloxacin 400 mg QD Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
4 Influence of Oral Telithromycin vs. Azithromycin on the Endogenous Microflora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
5 A Multicenter, Randomized Study to Compare the Safety and Efficacy of Oral Levofloxacin With Amoxicillin/Clavulanate Potassium in the Treatment of Acute Sinusitis in Adults Completed NCT00249210 Phase 3 levofloxacin
6 An Open-label, Multi-center, Non-comparative Sinus Puncture Study of 750 mg, Short-course Levofloxacin in the Treatment of Acute Maxillary Sinusitis Completed NCT00236652 Phase 3 levofloxacin
7 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Levofloxacin for the Treatment of Acute Bacterial Maxillary Sinusitis in Adults Undergoing Diagnostic Sinus Aspiration Completed NCT00643409 Phase 3 azithromycin SR (Zithromax; compound: CP-62,993);levofloxacin
8 AMS VS MOXI Ketek vs Avelox in AMS Completed NCT00537563 Phase 3 Telithromycin
9 Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis Unknown status NCT03083392
10 Pilot Study Designed to Clinically Evaluate Sinus Wash Device Prototypes in Patients With Sinusitis During Endoscopic Sinus Surgery (ESS) and in the Hospital Outpatient Unknown status NCT02931604
11 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis Completed NCT01032174 Azithromycin SR;Amoxiclav 1000 mg
12 Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis Completed NCT00683371
13 A Randomized Trial of the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinusplasty Completed NCT01990820
14 A Randomised Controlled Study of Endoscopic Sinus Surgery for Recurrent Acute Rhinosinusitis Recruiting NCT04241016
15 Multicenter Prospective Longitudinal Study on the Efficacy of Exclusive Odontological and Medical Treatment in the Management of Chronic Dental Maxillary Sinusitis Recruiting NCT04085536
16 Biomaterials in the Surgical Rehabilitation of Oral and Maxillofacial Hard and Soft Tissue Defects Active, not recruiting NCT04136509
17 A Placebo Controlled Randomised Study of the Balloon Sinuplasty Efficiency in Chronic or Recurrent Maxillary Rhinosinusitis. Not yet recruiting NCT04645511

Search NIH Clinical Center for Maxillary Sinusitis

Cochrane evidence based reviews: maxillary sinusitis

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Genetic Tests for Maxillary Sinusitis

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Anatomical Context for Maxillary Sinusitis

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MalaCards organs/tissues related to Maxillary Sinusitis:

40
Skin, Bone, Brain, Pituitary, Eye, Thyroid, Bone Marrow
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Publications for Maxillary Sinusitis

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Articles related to Maxillary Sinusitis:

(show top 50) (show all 1855)
# Title Authors PMID Year
1
Pathophysiology of current odontogenic maxillary sinusitis and endoscopic sinus surgery preceding dental treatment. 61
32763093 2021
2
Deep Learning for Diagnosis of Paranasal Sinusitis Using Multi-View Radiographs. 61
33562764 2021
3
Does the quality of residual alveolar bone apical to a periodontal lesion beneath the maxillary sinus play a vital role in preventing the extension of periodontal disease to maxillary sinus? A CBCT-assisted retrospective study. 61
33492255 2021
4
Performance of deep learning object detection technology in the detection and diagnosis of maxillary sinus lesions on panoramic radiographs. 61
32618480 2021
5
Developments, application, and performance of artificial intelligence in dentistry - A systematic review. 61
33384840 2021
6
Odontogenic maxillary sinusitis: A comprehensive review. 61
33384837 2021
7
Pyoderma gangrenosum associated with levamisole-adulterated cocaine in a c-ANCA positive patient. 61
33560793 2021
8
Microbiology, Histopathology, and Radiographic Findings in Silent Sinus Syndrome. 61
33463370 2021
9
Surgical Ciliated Cysts in Orthognathic Surgery. 61
32804812 2021
10
A rare case of polymicrobial chronic maxillary sinusitis due to concurrent isolation of Parvimonas micra and Fusobacterium nucleatum. 61
33068731 2020
11
Surgical Advances in the Management of the Silent Sinus Syndrome: Our Experience and Review of the Literature. 61
32814031 2020
12
HOSPITAL INTERVENTION IN SEVERE SINUS INFECTION AFTER BONE GRAFT. 61
33270877 2020
13
Ruptured long intramedullary spinal cord abscess successfully treated with antibiotic treatment. 61
33246901 2020
14
CBCT analysis of haller cells: relationship with accessory maxillary ostium and maxillary sinus pathologies. 61
33159621 2020
15
Chronic maxillary sinusitis of dental origin and oroantral fistula: The results of combined surgical approach in an Italian university hospital. 61
32358949 2020
16
Images of the month: Cavernous sinus venous thrombosis secondary to Streptococcus milleri maxillary sinusitis: An unusual cause of diplopia and headache. 61
33199337 2020
17
Evaluation of factors affecting the association between thickening of sinus mucosa and the presence of periapical lesions using cone beam CT. 61
32627204 2020
18
Actinomycosis: An Unusual Cause of Maxillary Sinusitis. 61
33048586 2020
19
Evaluation of Recurrent Maxillary Sinusitis due to Middle Meatal Antrostomy Site Stenosis. 61
32441108 2020
20
Eye Globe Rupture Caused by Dental Implant-Related Maxillary Sinusitis. 61
32618272 2020
21
A Novel Classification of Relationship Between Nasal Septum and Inferior Turbinate Associated With Nasal Airway Obstruction in Unilateral Alveolar Cleft Patients. 61
32956306 2020
22
Ectopic maxillary tooth as a cause of recurrent maxillary sinusitis: a case report and review of the literature. 61
33024531 2020
23
Comparison of Anatomical Features of Alveolar Cleft in Unilateral Cleft Lip and Palate Patients of Different Ages. 61
32796297 2020
24
Odontogenic Sinusitis-Associated Pott's Puffy Tumor: A Case Report and Literature Review. 61
32921154 2020
25
Medication-related osteonecrosis of the maxilla: Prognosis of oral surgery combined with endoscopic sinus surgery. 61
32810362 2020
26
[Radicality of maxillary sinus surgery and size of the maxillary sinus ostium]. 61
32405682 2020
27
Functional Endoscopic Sinus Surgery for Paranasal Sinusitis Originating From a Peri-implantitis-Triggered Infection in the Augmented Maxilla: A Case Report. 61
33031546 2020
28
Fungal ball of the maxillary sinus and the risk of persistent sinus dysfunction after simple antrostomy. 61
32466983 2020
29
Computed Tomography Image Analysis and Clinical Correlations of Retromaxillary Cells. 61
32627620 2020
30
Trans-implant treatment of chronic recurrent maxillary sinusitis via dynamic implants with an internal port: Experience with 31 cases. 61
32061430 2020
31
Intraoral Dual Wavelength Laser Diode Therapy for Chronic Maxillary Sinusitis. 61
32904078 2020
32
Quality assessment of systematic reviews regarding the effectiveness of zygomatic implants: an overview of systematic reviews. 61
32520920 2020
33
Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections. 61
32527201 2020
34
Gelatin Sponge Induced Maxillary Sinusitis After Transsphenoidal Pituitary Surgery. 61
32176010 2020
35
A dental implant dislocated in the ethmoidal sinus: A case report. 61
32490230 2020
36
Combined in-person and tele-delivered mobile school clinic: A novel approach for improving access to healthcare during school hours. 61
32393140 2020
37
Clinical Characteristics Other Than Intralesional Hyperdensity May Increase the Preoperative Diagnostic Accuracy of Maxillary Sinus Fungal Ball. 61
31674170 2020
38
A retrospective analysis of complications associated with tooth-borne anterior maxillary distraction for managing cleft maxillary hypoplasia: A 12-year experience. 61
32151516 2020
39
Reversible Endoscopic Medial Maxillectomy: Endonasal Approach to Diseases of the Maxillary Sinus. 61
32296472 2020
40
Odontogenic orbital inflammation. 61
32685776 2020
41
"Very High-Grade" Pulsatile Mass of an Aberrant Internal Carotid Artery in the Nasopharyngeal Wall: A Case Report and Review of Literature. 61
32282788 2020
42
Histopathology of maxillary sinus mucosa with odontogenic maxillary sinusitis. 61
32337350 2020
43
Computed tomography-based differential diagnosis of fungus balls in the maxillary sinus. 61
31471220 2020
44
Bone Regeneration and Soft Tissue Enhancement Around Zygomatic Implants: Retrospective Case Series. 61
32235372 2020
45
Endoscopic medial maxillectomy in patients treated at the Otorhinolaryngology and Laryngological Oncology Clinic of Military Institute of Medicine in Warsaw in the years 2008-2018. 61
32636346 2020
46
Managing Antral Wall Discontinuities in Sinus Elevation Surgery. 61
32064774 2020
47
Sinonasal Anatomical Variations and Primary Acquired Nasolacrimal Duct Obstruction: A Single Centre, Case-Control Investigation. 61
32158308 2020
48
Assessment of Bioabsorbable Hydroxyapatite for Secondary Bone Grafting in Unilateral Alveolar Clefts. 61
31422680 2020
49
Association between maxillary sinus pathology and odontogenic lesions in patients evaluated by cone beam computed tomography. A systematic review and meta-analysis. 61
31880293 2020
50
A Successful Treatment Regimen for the Prevention of Sinusitis after Maxillary Sinus Floor Elevation Surgery in a High-Risk Case. 61
32832181 2020
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Variations for Maxillary Sinusitis

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Expression for Maxillary Sinusitis

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Search GEO for disease gene expression data for Maxillary Sinusitis.
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Pathways for Maxillary Sinusitis

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Pathways related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 12.82 SERPINB6 RNASE3 PRTN3 MUC5B MPO IRAK4
2
Folate Metabolism 1
Show member pathways
 11.46 MPO CRP CCL5
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GO Terms for Maxillary Sinusitis

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Cellular components related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 SERPINB6 RNASE3 PRTN3 MUC5B MPO CRP
2 extracellular space GO:0005615 9.28 SERPINB6 SELP RNASE3 PRTN3 MUC5B MPO
3 azurophil granule lumen GO:0035578 9.13 RNASE3 PRTN3 MPO

Biological processes related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte cell-cell adhesion GO:0007159 8.96 SELP CCL5
2 neutrophil degranulation GO:0043312 8.92 SERPINB6 RNASE3 PRTN3 MPO

Molecular functions related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 SELP RNASE3
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Sources for Maxillary Sinusitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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