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MCID: MXL015
MIFTS: 36

Maxillary Sinusitis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Maxillary Sinusitis

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MalaCards integrated aliases for Maxillary Sinusitis:

Name: Maxillary Sinusitis 12 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2051
MeSH 43 D015523
NCIt 49 C34809
SNOMED-CT 67 88348008
ICD10 32 J32.0
UMLS 71 C0024959
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Summaries for Maxillary Sinusitis

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Disease Ontology : 12 A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.

MalaCards based summary : Maxillary Sinusitis is related to acute maxillary sinusitis and chronic maxillary sinusitis. An important gene associated with Maxillary Sinusitis is MPO (Myeloperoxidase), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Strawberry and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes, and related phenotype is immune system.

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Related Diseases for Maxillary Sinusitis

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Diseases in the Maxillary Sinusitis family:

Chronic Maxillary Sinusitis Acute Maxillary Sinusitis

Diseases related to Maxillary Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 acute maxillary sinusitis 34.8 OAF CRP
2 chronic maxillary sinusitis 33.9 RNASE3 PDPN OAF MPO AASDHPPT
3 pleural empyema 30.6 CRP CD40LG
4 hypereosinophilic syndrome 30.5 RNASE3 MPO CCL5
5 frontal sinusitis 30.5 OAF KIDINS220
6 ethmoid sinusitis 30.5 PRTN3 OAF CRP
7 cellulitis 30.2 RNASE3 CRP CD40LG
8 tolosa-hunt syndrome 30.1 PRTN3 CRP
9 bronchopneumonia 30.1 MPO CRP CD40LG
10 paranasal sinus disease 30.1 RNASE3 PRTN3 OAF MPO KIDINS220 CRP
11 bacterial conjunctivitis 30.0 CRP CD40LG
12 vasomotor rhinitis 30.0 RNASE3 CD40LG
13 chronic rhinitis 30.0 RNASE3 MPO KIDINS220
14 laryngitis 30.0 CRP CD40LG
15 common cold 29.9 SELP RNASE3 KIDINS220 CCL5
16 bacterial infectious disease 29.8 IRAK4 CRP CD40LG
17 urticaria 29.8 RNASE3 CRP CD40LG
18 thrombophlebitis 29.8 SELP CRP CD40LG
19 bone inflammation disease 29.7 PRTN3 CRP CD40LG
20 scarlet fever 29.7 CRP CD40LG
21 facial paralysis 29.5 PRTN3 CRP CD40LG
22 proteasome-associated autoinflammatory syndrome 1 29.4 SELP RNASE3 MPO CRP CCL5
23 meningitis 29.2 LACTB IRAK4 CRP CD40LG CCL5
24 middle ear disease 29.2 PRTN3 MPO CRP CD40LG
25 exanthem 29.2 PRTN3 MPO CRP CD40LG
26 bronchitis 29.1 RNASE3 MPO LACTB CRP CD40LG CCL5
27 erysipelas 29.0 CRP CD40LG
28 otitis media 28.9 RNASE3 MPO LACTB IRAK4 CRP CD40LG
29 lung disease 28.8 RNASE3 PRTN3 MPO CRP CD40LG CCL5
30 inflammatory bowel disease 28.5 SELP PRTN3 MPO CRP CD40LG CCL5
31 haemophilus influenzae 10.8
32 rhinitis 10.5
33 anaerobic pneumonia 10.5 MPO CCL5
34 vernal conjunctivitis 10.4 RNASE3 MPO
35 adhesive otitis media 10.4 RNASE3 MPO
36 purulent acute otitis media 10.4 PRTN3 MPO
37 vernal keratoconjunctivitis 10.4 RNASE3 CCL5
38 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.4
39 anca-associated vasculitis 10.4 PRTN3 MPO
40 periodontitis 10.4
41 pulmonary hemosiderosis 10.4 PRTN3 MPO
42 anti-basement membrane glomerulonephritis 10.3 PRTN3 MPO
43 cystic fibrosis 10.3
44 allergic rhinitis 10.3
45 aspergillosis 10.3
46 osteomyelitis 10.3
47 marginal corneal ulcer 10.3 MPO CRP
48 nocardiosis 10.3 LACTB CRP
49 bacteremia 2 10.3 LACTB CRP
50 enophthalmos 10.3

Graphical network of the top 20 diseases related to Maxillary Sinusitis:



Diseases related to Maxillary Sinusitis
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Symptoms & Phenotypes for Maxillary Sinusitis

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MGI Mouse Phenotypes related to Maxillary Sinusitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CCL5 CD40LG CRP IRAK4 MFSD10 MPO
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Drugs & Therapeutics for Maxillary Sinusitis

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Drugs for Maxillary Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Strawberry Approved Phase 4
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
4
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
8
Clarithromycin Approved Phase 4 81103-11-9 84029
9
Telithromycin Approved Phase 4 191114-48-4 70789201 5462516
10
Azithromycin Approved Phase 4 83905-01-5 447043 55185
11 Estradiol 17 beta-cypionate Phase 4
12 Contraceptives, Oral Phase 4
13 Estradiol 3-benzoate Phase 4
14 Contraceptives, Oral, Combined Phase 4
15 Contraceptive Agents Phase 4
16 Norgestimate, ethinyl estradiol drug combination Phase 4
17 Erythromycin Estolate Phase 4
18 Erythromycin stearate Phase 4
19 Erythromycin Ethylsuccinate Phase 4
20 Antibiotics, Antitubercular Phase 4
21
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
22
Ofloxacin Approved Phase 3 82419-36-1 4583
23
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
24
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
25 Anti-Infective Agents Phase 3
26 Anti-Bacterial Agents Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28
Xylometazoline Approved, Investigational 526-36-3 5709
29 Amoxicillin-Potassium Clavulanate Combination
30 beta-Lactamase Inhibitors
31 Analgesics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Clinical Relevance of Middle Meatal Bacteriology During Acute Respiratory Infection in Children - Randomised, Double-Blinded Clinical Study Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Prospective, Multicenter, Open, Uncontrolled Trial to Evaluate the Time to Bacterial Eradication and Key Symptom Relief in the Treatment of Acute Bacterial Maxillary Sinusitis With Moxifloxacin 400 mg QD Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
3 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
4 Influence of Oral Telithromycin vs. Azithromycin on the Endogenous Microflora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
5 AMS VS MOXI Ketek vs Avelox in AMS Completed NCT00537563 Phase 3 Telithromycin
6 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Levofloxacin for the Treatment of Acute Bacterial Maxillary Sinusitis in Adults Undergoing Diagnostic Sinus Aspiration Completed NCT00643409 Phase 3 azithromycin SR (Zithromax; compound: CP-62,993);levofloxacin
7 An Open-label, Multi-center, Non-comparative Sinus Puncture Study of 750 mg, Short-course Levofloxacin in the Treatment of Acute Maxillary Sinusitis Completed NCT00236652 Phase 3 levofloxacin
8 A Multicenter, Randomized Study to Compare the Safety and Efficacy of Oral Levofloxacin With Amoxicillin/Clavulanate Potassium in the Treatment of Acute Sinusitis in Adults Completed NCT00249210 Phase 3 levofloxacin
9 Management of HIV-Infected Patients at Risk of Recurrent Purulent Sinusitis: Role of Anti-Inflammatory, Antibacterial, and Decongestant Prophylaxis Withdrawn NCT00000752 Phase 2 Pseudoephedrine hydrochloride;Guaifenesin;Cefuroxime axetil;Beclomethasone dipropionate
10 Pilot Study Designed to Clinically Evaluate Sinus Wash Device Prototypes in Patients With Sinusitis During Endoscopic Sinus Surgery (ESS) and in the Hospital Outpatient Unknown status NCT02931604
11 Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis Unknown status NCT03083392
12 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis Completed NCT01032174 Azithromycin SR;Amoxiclav 1000 mg
13 Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis Completed NCT00683371
14 Postoperative Treatment After Endoscopic Sinus Surgery Completed NCT00534768
15 Open-label Comparative Safety and Efficacy Study of Levofloxacin and Amoxicillin Clavulanic Acid in Patients With Acute ,Bacterial Rhinosinusitis Completed NCT02712502 Levofloxacin;Amoxicillin-Potassium Clavulanate Combination
16 Multicenter Prospective Longitudinal Study on the Efficacy of Exclusive Odontological and Medical Treatment in the Management of Chronic Dental Maxillary Sinusitis Recruiting NCT04085536
17 A Randomised Controlled Study of Endoscopic Sinus Surgery for Recurrent Acute Rhinosinusitis Recruiting NCT04241016
18 Evaluation of Bone Height Gain Following Transcrestal Sinus Floor Elevation Using Piezoelectric Surgery Versus The Conventional Osteotome Technique in Patients With Atrophic Posterior Maxillae: A Randomized Controlled Clinical Trial Not yet recruiting NCT03944811

Search NIH Clinical Center for Maxillary Sinusitis

Cochrane evidence based reviews: maxillary sinusitis

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Genetic Tests for Maxillary Sinusitis

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Anatomical Context for Maxillary Sinusitis

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MalaCards organs/tissues related to Maxillary Sinusitis:

40
Bone, Eye, Testes, Skin, Brain, Pituitary, Lung
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Publications for Maxillary Sinusitis

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Articles related to Maxillary Sinusitis:

(show top 50) (show all 1815)
# Title Authors PMID Year
1
Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections. 61
32527201 2020
2
Quality assessment of systematic reviews regarding the effectiveness of zygomatic implants: an overview of systematic reviews. 61
32520920 2020
3
Gelatin Sponge Induced Maxillary Sinusitis After Transsphenoidal Pituitary Surgery. 61
32176010 2020
4
Combined in-person and tele-delivered mobile school clinic: A novel approach for improving access to healthcare during school hours. 61
32393140 2020
5
Clinical Characteristics Other Than Intralesional Hyperdensity May Increase the Preoperative Diagnostic Accuracy of Maxillary Sinus Fungal Ball. 61
31674170 2020
6
[Radicality of maxillary sinus surgery and size of the maxillary sinus ostium]. 61
32405682 2020
7
Evaluation of Recurrent Maxillary Sinusitis due to Middle Meatal Antrostomy Site Stenosis. 61
32441108 2020
8
A dental implant dislocated in the ethmoidal sinus: A case report. 61
32490230 2020
9
Fungal ball of the maxillary sinus and the risk of persistent sinus dysfunction after simple antrostomy. 61
32466983 2020
10
Reversible Endoscopic Medial Maxillectomy: Endonasal Approach to Diseases of the Maxillary Sinus. 61
32296472 2020
11
Histopathology of maxillary sinus mucosa with odontogenic maxillary sinusitis. 61
32337350 2020
12
"Very High-Grade" Pulsatile Mass of an Aberrant Internal Carotid Artery in the Nasopharyngeal Wall: A Case Report and Review of Literature. 61
32282788 2020
13
Chronic maxillary sinusitis of dental origin and oroantral fistula: The results of combined surgical approach in an Italian university hospital. 61
32358949 2020
14
A retrospective analysis of complications associated with tooth-borne anterior maxillary distraction for managing cleft maxillary hypoplasia: A 12-year experience. 61
32151516 2020
15
Computed tomography-based differential diagnosis of fungus balls in the maxillary sinus. 61
31471220 2020
16
Bone Regeneration and Soft Tissue Enhancement Around Zygomatic Implants: Retrospective Case Series. 61
32235372 2020
17
Sinonasal Anatomical Variations and Primary Acquired Nasolacrimal Duct Obstruction: A Single Centre, Case-Control Investigation. 61
32158308 2020
18
Managing Antral Wall Discontinuities in Sinus Elevation Surgery. 61
32064774 2020
19
Trans-implant treatment of chronic recurrent maxillary sinusitis via dynamic implants with an internal port: Experience with 31 cases. 61
32061430 2020
20
A Rare Case of Palpebral Cellulitis, a Variation of Pott's Puffy Tumor. 61
32308611 2020
21
[Modification of the method for closing the defect of the medial wall of the maxillary sinus]. 61
32476387 2020
22
Treatment of Recalcitrant Maxillary Sinusitis With Endoscopic Modified Medial Maxillectomy: A Systematic Review of Safety and Efficacy. 61
31537079 2020
23
Association between maxillary sinus pathology and odontogenic lesions in patients evaluated by cone beam computed tomography. A systematic review and meta-analysis. 61
31880293 2020
24
Assessment of Bioabsorbable Hydroxyapatite for Secondary Bone Grafting in Unilateral Alveolar Clefts. 61
31422680 2020
25
Accessory Maxillary Ostia: Prevalence of an Anatomical Variant and Association with Chronic Sinusitis. 61
32440195 2020
26
Swing door technique for uncinectomy versus standard technique: a comparative study. 61
31820008 2019
27
Odontogenic sinusitis is a common cause of unilateral sinus disease with maxillary sinus opacification. 61
31529785 2019
28
Definition and management of odontogenic maxillary sinusitis. 61
30989083 2019
29
Does Middle Meatal Antrostomy Prevent the Onset of Maxillary Sinusitis After Zygomatic Implant Placement? 61
31445033 2019
30
Combined endoscopic and intra-oral approach for chronic maxillary sinusitis of dental origin-a prospective clinical study. 61
31332583 2019
31
Floating septum technique: easy and safe method maxillary sinus septa in sinus lifting procedure. 61
31824892 2019
32
Combination of amphotericin B and caspofungin in the treatment of mucormycosis. 61
31667058 2019
33
Modified Le Fort I step osteotomy for improvement of paranasal flatness in maxillary deficiency: Technical note and series of 24 cases. 61
31299342 2019
34
Surgical fenestrated approach to the maxillary sinus like alternative to Caldwell-Luc technique. 61
32052620 2019
35
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (4), CT and MR imaging findings of antiresorptive agent-related osteonecrosis of the jaws/medication-related osteonecrosis of the jaw (secondary publication). 61
30815046 2019
36
Does Endoscopic Sinus Surgery (ESS) Retrieve Mucociliary Clearance of Maxillary Sinus: Prospective Study at a Tertiary Care Hospital. 61
31763322 2019
37
Visibility, location, and morphology of the primary maxillary sinus ostium and presence of accessory ostia: a retrospective analysis using cone beam computed tomography (CBCT). 61
30737619 2019
38
Challenges in diagnosing odontogenic lesions in maxillary sinuses. 61
32398384 2019
39
Odontogenic Fungal Maxillary Sinusitis: A Case Report of a Displaced Dental Foreign Body. 61
31763250 2019
40
Recurrent Maxillary Sinusitis and Periorbital Cellulitis Revealing an Unnoticed Medial Wall Orbital Fracture. 61
31490444 2019
41
Premaxillary abscess without bony erosion: An unusual complication of pediatric acute maxillary sinusitis. 61
31427214 2019
42
Ectopic Third Molar: A Hidden Cause For Maxillary Sinusitis-A Rare Case Report. 61
31742075 2019
43
Maxillary Sinusitis Associated With Peri-implantitis at Sinus Floor Augmented Sites: Case Series. 61
31219944 2019
44
Treatment of Maxillary Sinusitis of Odontogenic Origin: A Case Series. 61
31478698 2019
45
Guidelines of the French Society of Otorhinolaryngology (SFORL): Nonsteroidal anti-inflammatory drugs (NSAIDs) and pediatric ENT infections. Short version. 61
31420238 2019
46
Characteristics of Chronic Maxillary Sinusitis in Patients With a History of Long-term Bisphosphonate Use. 61
31041868 2019
47
Deep-learning classification using convolutional neural network for evaluation of maxillary sinusitis on panoramic radiography. 61
30539342 2019
48
Conflicts between histologic and clinical/radiologic findings in functional endoscopic sinus surgery for managing maxillary sinusitis following sinus augmentation: A case report. 61
31184635 2019
49
Maxillary sinus aspergillosis: a case report of the timely failure to treatment. 61
31719967 2019
50
Single-step surgical treatment of odontogenic maxillary sinusitis: A retrospective study of 98 cases. 61
31138486 2019
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Variations for Maxillary Sinusitis

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Expression for Maxillary Sinusitis

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Search GEO for disease gene expression data for Maxillary Sinusitis.
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Pathways for Maxillary Sinusitis

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Pathways related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.44 MPO IRAK4 CD40LG CCL5
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GO Terms for Maxillary Sinusitis

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Cellular components related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 SELP RNASE3 PRTN3 MPO IRAK4 CRP
2 azurophil granule lumen GO:0035578 9.13 RNASE3 PRTN3 MPO

Biological processes related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.26 SELP CRP CD40LG CCL5
2 leukocyte cell-cell adhesion GO:0007159 8.8 SELP CD40LG CCL5
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Sources for Maxillary Sinusitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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