MCID: MXL015
MIFTS: 37

Maxillary Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Maxillary Sinusitis

MalaCards integrated aliases for Maxillary Sinusitis:

Name: Maxillary Sinusitis 12 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2051
MeSH 44 D015523
NCIt 50 C34809
SNOMED-CT 68 88348008
ICD10 33 J32.0
UMLS 72 C0024959

Summaries for Maxillary Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.

MalaCards based summary : Maxillary Sinusitis is related to chronic maxillary sinusitis and bronchitis. An important gene associated with Maxillary Sinusitis is IRAK4 (Interleukin 1 Receptor Associated Kinase 4), and among its related pathways/superpathways are NF-kappaB Signaling and amb2 Integrin signaling. The drugs Strawberry and Moxifloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes.

Related Diseases for Maxillary Sinusitis

Diseases in the Maxillary Sinusitis family:

Chronic Maxillary Sinusitis Acute Maxillary Sinusitis

Diseases related to Maxillary Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 chronic maxillary sinusitis 34.8 RNASE3 MPO
2 bronchitis 30.1 RNASE3 MPO
3 extrinsic allergic alveolitis 30.0 MPO CCL5
4 lung disease 29.9 RNASE3 MPO CCL5
5 common cold 29.8 SELP RNASE3 CCL5
6 asthma 29.2 SELP RNASE3 MPO CCL5
7 proteasome-associated autoinflammatory syndrome 1 29.0 SELP RNASE3 MPO CCL5
8 acute maxillary sinusitis 12.9
9 paranasal sinus disease 11.3
10 haemophilus influenzae 10.8
11 rhinitis 10.5
12 pleural empyema 10.4
13 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.4
14 periodontitis 10.3
15 ethmoid sinusitis 10.3
16 cystic fibrosis 10.3
17 allergic rhinitis 10.3
18 aspergillosis 10.3
19 osteomyelitis 10.3
20 enophthalmos 10.3
21 chronic eosinophilic pneumonia 10.2 RNASE3 CCL5
22 eosinophilic pneumonia 10.2 RNASE3 CCL5
23 status asthmaticus 10.2 RNASE3 CCL5
24 immune-complex glomerulonephritis 10.2 SELP MPO
25 collagenous colitis 10.2 RNASE3 MPO
26 osteonecrosis 10.2
27 suppurative periapical periodontitis 10.2
28 cellulitis 10.2
29 headache 10.2
30 chronic conjunctivitis 10.2 RNASE3 CCL5
31 kimura disease 10.2 RNASE3 CCL5
32 henoch-schoenlein purpura 10.2 RNASE3 MPO
33 vernal keratoconjunctivitis 10.2 RNASE3 CCL5
34 proctitis 10.2 RNASE3 MPO
35 otitis media 10.2
36 orbital cellulitis 10.2
37 bronchopneumonia 10.2
38 bone inflammation disease 10.2
39 exophthalmos 10.2
40 odontoma 10.2
41 churg-strauss syndrome 10.2 RNASE3 MPO
42 pulmonary eosinophilia 10.1 RNASE3 CCL5
43 vernal conjunctivitis 10.1 RNASE3 MPO
44 beta-thalassemia 10.1
45 ptosis 10.1
46 thalassemia 10.1
47 endocarditis 10.1
48 frontal sinusitis 10.1
49 chlamydia 10.1
50 subdural empyema 10.1

Graphical network of the top 20 diseases related to Maxillary Sinusitis:



Diseases related to Maxillary Sinusitis

Symptoms & Phenotypes for Maxillary Sinusitis

Drugs & Therapeutics for Maxillary Sinusitis

Drugs for Maxillary Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Strawberry Approved Phase 4
2
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
3
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
4
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
5
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Clarithromycin Approved Phase 4 81103-11-9 84029
8
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 441411 12560
9
Telithromycin Approved Phase 4 191114-48-4 5462516 70789201
10
Azithromycin Approved Phase 4 83905-01-5 447043 55185
11 Contraceptives, Oral Phase 4
12 Contraceptives, Oral, Combined Phase 4
13 Contraceptive Agents Phase 4
14 Norgestimate, ethinyl estradiol drug combination Phase 4
15 Topoisomerase Inhibitors Phase 4
16 Estradiol 3-benzoate Phase 4
17 Estradiol 17 beta-cypionate Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Cytochrome P-450 CYP3A Inhibitors Phase 4
20 Antitubercular Agents Phase 4
21 Erythromycin Ethylsuccinate Phase 4
22 Erythromycin stearate Phase 4
23 Erythromycin Estolate Phase 4
24 Antibiotics, Antitubercular Phase 4
25
Ofloxacin Approved Phase 3 82419-36-1 4583
26
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
27
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
28
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
29 Renal Agents Phase 3
30 Anti-Infective Agents, Urinary Phase 3
31 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
32 Amoxicillin-Potassium Clavulanate Combination Phase 3
33 beta-Lactamase Inhibitors Phase 3
34
Xylometazoline Approved, Investigational 526-36-3 5709

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Clinical Relevance of Middle Meatal Bacteriology During Acute Respiratory Infection in Children - Randomised, Double-Blinded Clinical Study Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Prospective, Multicenter, Open, Uncontrolled Trial to Evaluate the Time to Bacterial Eradication and Key Symptom Relief in the Treatment of Acute Bacterial Maxillary Sinusitis With Moxifloxacin 400 mg QD Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
3 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
4 Influence of Oral Telithromycin vs. Azithromycin on the Endogenous Microflora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
5 AMS VS MOXI Ketek vs Avelox in AMS Completed NCT00537563 Phase 3 Telithromycin
6 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Levofloxacin for the Treatment of Acute Bacterial Maxillary Sinusitis in Adults Undergoing Diagnostic Sinus Aspiration Completed NCT00643409 Phase 3 azithromycin SR (Zithromax; compound: CP-62,993);levofloxacin
7 An Open-label, Multi-center, Non-comparative Sinus Puncture Study of 750 mg, Short-course Levofloxacin in the Treatment of Acute Maxillary Sinusitis Completed NCT00236652 Phase 3 levofloxacin
8 A Multicenter, Randomized Study to Compare the Safety and Efficacy of Oral Levofloxacin With Amoxicillin/Clavulanate Potassium in the Treatment of Acute Sinusitis in Adults Completed NCT00249210 Phase 3 levofloxacin
9 Management of HIV-Infected Patients at Risk of Recurrent Purulent Sinusitis: Role of Anti-Inflammatory, Antibacterial, and Decongestant Prophylaxis Withdrawn NCT00000752 Phase 2 Pseudoephedrine hydrochloride;Guaifenesin;Cefuroxime axetil;Beclomethasone dipropionate
10 Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis Unknown status NCT03083392
11 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis Completed NCT01032174 Azithromycin SR;Amoxiclav 1000 mg
12 Postoperative Treatment After Endoscopic Sinus Surgery Completed NCT00534768
13 Open-label Comparative Safety and Efficacy Study of Levofloxacin and Amoxicillin Clavulanic Acid in Patients With Acute ,Bacterial Rhinosinusitis Completed NCT02712502 Levofloxacin;Amoxicillin-Potassium Clavulanate Combination
14 Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis Active, not recruiting NCT00683371
15 Pilot Study Designed to Clinically Evaluate Sinus Wash Device Prototypes in Patients With Sinusitis During Endoscopic Sinus Surgery (ESS) and in the Hospital Outpatient Not yet recruiting NCT02931604
16 Evaluation of Bone Height Gain Following Transcrestal Sinus Floor Elevation Using Piezoelectric Surgery Versus The Conventional Osteotome Technique in Patients With Atrophic Posterior Maxillae: A Randomized Controlled Clinical Trial Not yet recruiting NCT03944811

Search NIH Clinical Center for Maxillary Sinusitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cefuroxime

Cochrane evidence based reviews: maxillary sinusitis

Genetic Tests for Maxillary Sinusitis

Anatomical Context for Maxillary Sinusitis

MalaCards organs/tissues related to Maxillary Sinusitis:

41
Bone, Eye, Testes, Skin, Brain, Thyroid, Pituitary

Publications for Maxillary Sinusitis

Articles related to Maxillary Sinusitis:

(show top 50) (show all 1776)
# Title Authors PMID Year
1
Definition and management of odontogenic maxillary sinusitis. 38
30989083 2019
2
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (4), CT and MR imaging findings of antiresorptive agent-related osteonecrosis of the jaws/medication-related osteonecrosis of the jaw (secondary publication). 38
30815046 2019
3
Deep-learning classification using convolutional neural network for evaluation of maxillary sinusitis on panoramic radiography. 38
30539342 2019
4
Single-step surgical treatment of odontogenic maxillary sinusitis: A retrospective study of 98 cases. 38
31138486 2019
5
Guidelines of the French Society of Otorhinolaryngology (SFORL): Nonsteroidal anti-inflammatory drugs (NSAIDs) and pediatric ENT infections. Short version. 38
31420238 2019
6
Premaxillary abscess without bony erosion: An unusual complication of pediatric acute maxillary sinusitis. 38
31427214 2019
7
Assessment of Bioabsorbable Hydroxyapatite for Secondary Bone Grafting in Unilateral Alveolar Clefts. 38
31422680 2019
8
Repair of oroantral fistula via modified endoscopic medial maxillectomy with free nasal mucoperichondrial-osteal graft. 38
31107127 2019
9
Combined endoscopic and intra-oral approach for chronic maxillary sinusitis of dental origin-a prospective clinical study. 38
31332583 2019
10
Imaging of odontogenic sinusitis. 38
30926134 2019
11
Modified Le Fort I step osteotomy for improvement of paranasal flatness in maxillary deficiency: Technical note and series of 24 cases. 38
31299342 2019
12
Surgical anatomy of the nasal and paranasal sinuses in Egyptian native sheep (Ovis aries) using computed tomography and cross sectioning. 38
30957277 2019
13
Is post orthognathic maxillary sinusitis related to sino-nasal anatomical alterations? 38
30935854 2019
14
Maxillary Sinusitis Associated With Peri-implantitis at Sinus Floor Augmented Sites: Case Series. 38
31219944 2019
15
Correlation between prevelance of Haller cells and postoperative maxillary sinusitis after sinus lifting Procedure. 38
31085018 2019
16
Anatomical Variation in Maxillary Sinus Ostium Positioning: Implications for Nasal-Sinus Disease. 38
30471207 2019
17
Conflicts between histologic and clinical/radiologic findings in functional endoscopic sinus surgery for managing maxillary sinusitis following sinus augmentation: A case report. 38
31184635 2019
18
Improvement diagnostic accuracy of sinusitis recognition in paranasal sinus X-ray using multiple deep learning models. 38
31367548 2019
19
Characteristics of Chronic Maxillary Sinusitis in Patients With a History of Long-term Bisphosphonate Use. 38
31041868 2019
20
Autologous Fat Injection for the Correction of Facial Depression Resulting From Silent Sinus Syndrome. 38
30550442 2019
21
Rapid remodeling of the maxillary sinus in silent sinus syndrome. 38
29742007 2019
22
Long-Term Effectiveness of Balloon Catheter Sinuplasty in Pediatric Chronic Maxillary Sinusitis. 38
30943802 2019
23
AEROBIC MICROFLORA IN THE PATHOGENESIS OF MAXILLARY SINUSITIS AFTER THE TREATMENT OF CARIES COMPLICATIONS. 38
31215877 2019
24
A Rare Case of Odontogenic Chronic Suppurative Otitis Media. 38
31172000 2019
25
Evaluation of Odontogenic Maxillary Sinusitis with Cone Beam Computed Tomography: A Retrospective Study with Review of Literature. 38
31058071 2019
26
Fungus Ball of the Maxillary Sinus-Modern Treatment by Osteoplastic Approach and Functional Endoscopic Sinus Surgery. 38
30448431 2019
27
Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis. 38
30651053 2019
28
[Effect of nonoperative periodontal treatment on changes of schneiderian membrane thickness of maxillary sinus in the chronic periodontitis patients using cone-beam CT]. 38
30695909 2019
29
[A Case of Subdural Empyema with Cerebral Arteritis and Brain Ischemia in the Middle Cerebral Artery Distribution, Secondary to Odontogenic Maxillary Sinusitis]. 38
30818277 2019
30
Visibility, location, and morphology of the primary maxillary sinus ostium and presence of accessory ostia: a retrospective analysis using cone beam computed tomography (CBCT). 38
30737619 2019
31
Comparison of Sino-Nasal Outcome Test 22 Symptom Scores in Rhinogenic and Odontogenic Sinusitis. 38
30311505 2019
32
Silent Sinus Syndrome. 38
31238693 2019
33
Nasal nitric oxide is a useful biomarker for acute unilateral maxillary sinusitis in pediatric allergic rhinitis: A prospective observational cohort study. 38
31193296 2019
34
Relapsing granulomatosis with polyangiitis provoked by trauma: A case report. 38
30653170 2019
35
Deep Learning in Diagnosis of Maxillary Sinusitis Using Conventional Radiography. 38
30067607 2019
36
[Facial abscess revealing maxillary sinusitis of dental origin]. 38
31223405 2019
37
Endoscopic Endonasal Surgery for Sinus Fungus Balls: Clinical, Radiological, Histopathological, and Microbiological Analysis of 40 Cases and Review of the Literature. 38
30783597 2019
38
The Rationale for Endoscopic Inferior Meatal Antrostomy. 38
30739105 2019
39
Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report. 38
30681599 2019
40
Predictive Significance of Radiographic Density of Sinus Opacity and Bone Thickness in Unilateral Maxillary Sinus Mycetoma. 38
31238303 2019
41
Reconstruction of large oroantral defects using a pedicled buccal fat pad. 38
29637060 2018
42
Maxillary sinusitis complicated by stroke. 38
30072286 2018
43
Bilateral subdural empyemas with meningitis secondary to acute barosinusitis. 38
30337240 2018
44
Subdural empyema as a complication of odontogenic maxillary sinusitis. 38
28843931 2018
45
Is dental evaluation considered in unilateral maxillary sinusitis? A retrospective case series. 38
30045653 2018
46
Chronic sinusitis of odontogenic origin due to an undiagnosed displaced root fragment in the maxillary sinus and the role of cone beam computed tomography in successful management. 38
30589019 2018
47
Closure of Oroantral Fistula With Buccal Fat Pad Flap and Endoscopic Drainage of the Maxillary Sinus. 38
29927825 2018
48
Complications and Management of Implants Migrated into the Maxillary Sinus. 38
29897353 2018
49
Efficacy of sinus ultrasound in diagnosis of acute and subacute maxillary sinusitis. 38
29779998 2018
50
Nonhealing orbital floor fracture in a pediatric patient: A unique presentation of pseudo-silent sinus syndrome. 38
29319378 2018

Variations for Maxillary Sinusitis

Expression for Maxillary Sinusitis

Search GEO for disease gene expression data for Maxillary Sinusitis.

Pathways for Maxillary Sinusitis

Pathways related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 MPO IRAK4 CCL5
2 10.3 SELP MPO

GO Terms for Maxillary Sinusitis

Cellular components related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 SELP RNASE3 MPO IRAK4 CCL5
2 azurophil granule lumen GO:0035578 8.96 RNASE3 MPO

Biological processes related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.26 SELP RNASE3
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.16 SELP CCL5
3 positive regulation of smooth muscle cell proliferation GO:0048661 8.96 IRAK4 CCL5
4 leukocyte cell-cell adhesion GO:0007159 8.62 SELP CCL5

Molecular functions related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 SELP RNASE3

Sources for Maxillary Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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