MCID: MXL015
MIFTS: 38

Maxillary Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Maxillary Sinusitis

MalaCards integrated aliases for Maxillary Sinusitis:

Name: Maxillary Sinusitis 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2051
ICD10 33 J32.0
MeSH 44 D015523
NCIt 50 C34809
SNOMED-CT 68 275484005 88348008
UMLS 73 C0024959

Summaries for Maxillary Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.

MalaCards based summary : Maxillary Sinusitis is related to chronic maxillary sinusitis and paranasal sinus disease. An important gene associated with Maxillary Sinusitis is IRAK4 (Interleukin 1 Receptor Associated Kinase 4), and among its related pathways/superpathways are NF-kappaB Signaling and amb2 Integrin signaling. The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and testes.

Related Diseases for Maxillary Sinusitis

Diseases in the Maxillary Sinusitis family:

Chronic Maxillary Sinusitis Acute Maxillary Sinusitis

Diseases related to Maxillary Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 chronic maxillary sinusitis 32.2 CD79A MPO RHNO1 RNASE3
2 paranasal sinus disease 31.0 CD79A RHNO1
3 common cold 29.4 CCL5 RNASE3 SELP
4 bronchitis 29.0 CD79A MPO RNASE3
5 acute maxillary sinusitis 12.6
6 sinusitis 11.6
7 proctitis 10.5 MPO RNASE3
8 chronic eosinophilic pneumonia 10.4 CCL5 RNASE3
9 churg-strauss syndrome 10.4 MPO RNASE3
10 chronic conjunctivitis 10.4 CCL5 RNASE3
11 status asthmaticus 10.4 CCL5 RNASE3
12 kimura disease 10.4 CCL5 RNASE3
13 vernal keratoconjunctivitis 10.4 CCL5 RNASE3
14 immune-complex glomerulonephritis 10.4 MPO SELP
15 pulmonary eosinophilia 10.3 CCL5 RNASE3
16 eosinophilic pneumonia 10.3 CCL5 RNASE3
17 chronic rhinitis 10.3 MPO RHNO1
18 onchocerciasis 10.3 CCL5 RNASE3
19 bronchial disease 10.2 CCL5 RNASE3
20 multiple cranial nerve palsy 10.2 MPO RHNO1
21 mucositis 10.1
22 ige responsiveness, atopic 10.1 RNASE3 SELP
23 nasal cavity disease 10.1 RHNO1 RNASE3
24 monoclonal paraproteinemia 10.1 CD79A MPO
25 rapidly progressive glomerulonephritis 10.0 CD79A MPO
26 bronchiolitis 10.0 CCL5 RNASE3
27 hypersensitivity vasculitis 10.0 CD79A MPO
28 goodpasture syndrome 10.0 CD79A MPO
29 acute proliferative glomerulonephritis 10.0 CD79A MPO
30 headache 10.0
31 bronchopneumonia 10.0 CD79A MPO
32 chronic interstitial cystitis 10.0 CD79A RNASE3
33 cow milk allergy 10.0 CD79A RNASE3
34 hypersensitivity reaction type iii disease 10.0 CD79A MPO
35 pulmonary disease, chronic obstructive 10.0 CCL5 MPO RNASE3
36 vulvitis 10.0 CD79A MPO
37 pleuropneumonia 10.0 CD79A IRAK4
38 periodontosis 10.0 CD79A MPO
39 ulcerative stomatitis 10.0 CD79A MPO
40 pulmonary hemosiderosis 10.0 CD79A MPO
41 nasopharyngitis 10.0
42 enophthalmos 10.0
43 odontoma 10.0
44 pollen allergy 9.9 CD79A RNASE3
45 milk allergy 9.9 CD79A RNASE3
46 inclusion conjunctivitis 9.9 CCL5 CD79A
47 orofacial granulomatosis 9.9 CCL5 CD79A
48 shigellosis 9.9 CD79A IRAK4
49 cystic fibrosis 9.9
50 osteonecrosis 9.9

Graphical network of the top 20 diseases related to Maxillary Sinusitis:



Diseases related to Maxillary Sinusitis

Symptoms & Phenotypes for Maxillary Sinusitis

Drugs & Therapeutics for Maxillary Sinusitis

Drugs for Maxillary Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
3
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
8
Clarithromycin Approved Phase 4 81103-11-9 84029
9
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
10
Telithromycin Approved Phase 4,Phase 3 191114-48-4 5462516 0
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2
13 Contraceptive Agents Phase 4
14 Contraceptives, Oral Phase 4
15 Contraceptives, Oral, Combined Phase 4
16 Estradiol 17 beta-cypionate Phase 4
17 Estradiol 3-benzoate Phase 4
18 Fluoroquinolones Phase 4
19 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
20 Nucleic Acid Synthesis Inhibitors Phase 4
21 Topoisomerase Inhibitors Phase 4,Phase 3
22 Antibiotics, Antitubercular Phase 4
23 Antitubercular Agents Phase 4
24 Cytochrome P-450 CYP3A Inhibitors Phase 4
25 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
26 Erythromycin Estolate Phase 4
27 Erythromycin Ethylsuccinate Phase 4
28 Erythromycin stearate Phase 4
29
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
30
Ofloxacin Approved Phase 3 82419-36-1 4583
31
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
32 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
33 Renal Agents Phase 3
34 Amoxicillin-Potassium Clavulanate Combination Phase 3
35 beta-Lactamase Inhibitors Phase 3
36 Clavulanic Acid Phase 3
37
Ephedrine Approved Phase 2 299-42-3 9294
38
Pseudoephedrine Approved Phase 2 90-82-4 7028
39 Adrenergic Agents Phase 2
40 Anti-Asthmatic Agents Phase 2
41 Autonomic Agents Phase 2
42 Bronchodilator Agents Phase 2
43 Central Nervous System Stimulants Phase 2
44 Nasal Decongestants Phase 2
45 Neurotransmitter Agents Phase 2
46 Peripheral Nervous System Agents Phase 2
47 Respiratory System Agents Phase 2
48 Vasoconstrictor Agents Phase 2
49
Xylometazoline Approved, Investigational 526-36-3 5709

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
2 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
3 Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
4 A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days. Completed NCT00236652 Phase 3 levofloxacin
5 A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults Completed NCT00643409 Phase 3 azithromycin SR (Zithromax; compound: CP-62,993);levofloxacin
6 AMS VS MOXI Ketek vs Avelox in AMS Completed NCT00537563 Phase 3 Telithromycin
7 A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses Completed NCT00249210 Phase 3 levofloxacin
8 Preventing Frequent Sinus Infections in HIV-Infected Patients Withdrawn NCT00000752 Phase 2 Pseudoephedrine hydrochloride;Guaifenesin;Cefuroxime axetil;Beclomethasone dipropionate
9 Acute Upper Respiratory Tract Infection - When is Bacteria Involved? Unknown status NCT01580137
10 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis Completed NCT01032174 Azithromycin SR;Amoxiclav 1000 mg
11 Levofloxacin in Bacterial Rhinosinussitis Completed NCT02712502 Levofloxacin;Amoxicillin-Potassium Clavulanate Combination
12 Postoperative Treatment After Endoscopic Sinus Surgery Completed NCT00534768 Not Applicable
13 Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis Active, not recruiting NCT00683371 Not Applicable
14 Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis Not yet recruiting NCT03083392 Not Applicable
15 Study Designed to Clinically Evaluate Sinus Wash Device Prototypes Not yet recruiting NCT02931604 Not Applicable
16 Zygomatic Versus Conventional Dental Implants in Augmented Maxillae Withdrawn NCT01961284 Not Applicable

Search NIH Clinical Center for Maxillary Sinusitis

Cochrane evidence based reviews: maxillary sinusitis

Genetic Tests for Maxillary Sinusitis

Anatomical Context for Maxillary Sinusitis

MalaCards organs/tissues related to Maxillary Sinusitis:

41
Eye, Bone, Testes, Tonsil, Colon, Skin

Publications for Maxillary Sinusitis

Articles related to Maxillary Sinusitis:

(show top 50) (show all 367)
# Title Authors Year
1
Clinical implications of taste thresholds in patients with odontogenic maxillary sinusitis. ( 29174862 )
2018
2
ACTUAL ISSUES OF ODONTOGENIC MAXILLARY SINUSITIS (REVIEW). ( 29697380 )
2018
3
Efficacy of sinus ultrasound in diagnosis of acute and subacute maxillary sinusitis. ( 29779998 )
2018
4
Treatment options for odontogenic maxillary sinusitis: a review. ( 29806655 )
2018
5
A Case of Fungus Ball-Type Maxillary Sinusitis Due to Penicillium Roqueforti. ( 29075960 )
2017
6
Haemophilus parainfluenzae Endocarditis Associated With Maxillary Sinusitis and Complicated by Cerebral Emboli in a Young Man. ( 28491883 )
2017
7
Unusual case of odontogenic maxillary sinusitis. ( 28747419 )
2017
8
When Maxillary Sinusitis Does Not Heal: Findings on CBCT Scans of the Sinuses With a Particular Focus on the Occurrence of Odontogenic Causes of Maxillary Sinusitis. ( 29299521 )
2017
9
Nasal Septal Deviation and Concha Bullosa - Do They Have an Impact on Maxillary Sinus Volumes and Prevalence of Maxillary Sinusitis? ( 28348652 )
2017
10
Novel approach to the maxillary sinusitis after sinus graft. ( 28695114 )
2017
11
Role of Sinonasal Anatomic Variations in the Development of Maxillary Sinusitis: A Cone Beam CT Analysis. ( 28839485 )
2017
12
Subdural empyema as a complication of odontogenic maxillary sinusitis. ( 28843931 )
2017
13
Maxillary sinuses and midface in patients with cleidocranial dysostosis. ( 28889021 )
2017
14
Clinical efficacy of main radiological diagnostic methods for odontogenic maxillary sinusitis. ( 28733779 )
2017
15
Metastatic mammary carcinoma to the orbit masquerading as maxillary sinusitis. ( 27103558 )
2016
16
Chronic Maxillary Sinusitis Caused by Denture Lining Material. ( 27386012 )
2016
17
Near-Infrared Optical Imaging for Diagnosis of Maxillary Sinusitis. ( 27329417 )
2016
18
A 44-Year-Old Man with Waldenstrom Macroglobulinemia and Bilateral Maxillary Sinusitis. ( 27840358 )
2016
19
Sporotrichosis of Maxillary Sinuses in a Middle Aged Female Patient from Rural Area of Eastern India. ( 27134873 )
2016
20
Salmonella enterica Subspecies diarizonae Maxillary Sinusitis in a Snake Handler: First Report. ( 27186588 )
2016
21
Are Zygomatic Implants Associated With Maxillary Sinusitis? ( 27070844 )
2016
22
Prevalence of chronic maxillary sinusitis in children from rural and urban skeletal populations in Poland. ( 29539544 )
2016
23
Root Cause Analysis: An Examination of Odontogenic Origins of Acute Maxillary Sinusitis in Both Immunocompetent & Immunocompromised Patients. ( 27798445 )
2016
24
Radiological and clinical difficulties in the management of chronic maxillary sinusitis in I^ Thalassemic paediatric patients. ( 27063757 )
2016
25
Utilization of computer-aided detection system in diagnosing unilateral maxillary sinusitis on panoramic radiographs. ( 26837670 )
2016
26
Haemophilus parainfluenzae endocarditis with systemic embolisation following maxillary sinusitis. ( 27599807 )
2016
27
Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst. ( 27422628 )
2016
28
Management of acute maxillary sinusitis after sinus bone grafting procedures with simultaneous dental implants placement - a retrospective study. ( 27169511 )
2016
29
Intra-oral low level laser therapy in chronic maxillary sinusitis: A new and effective recommended technique. ( 26644829 )
2015
30
Odontogenic maxillary sinusitis obscured by midfacial trauma. ( 26183855 )
2015
31
Impact of beta thalassemia on maxillary sinuses and sino-nasal passages: A case control study. ( 26553397 )
2015
32
WITHDRAWN: Antibiotics for acute maxillary sinusitis in adults. ( 26471061 )
2015
33
[The role of accessory ostia of the maxillary sinuses in pathogenesis of acute and chronic maxillary sinusitis]. ( 26640843 )
2015
34
Etiology and clinical characteristics of symptomatic unilateral maxillary sinusitis: A review of 174 cases. ( 26319958 )
2015
35
Chronic maxillary sinusitis and diabetes related maxillary osteonecrosis: a case report. ( 26734561 )
2015
36
Distinguishing the dominant species of pathogen in maxillary sinusitis by sequencing DNA dataset analysis. ( 25724392 )
2015
37
Maxillary sinusitis diagnosed by ultrasound. ( 25952933 )
2015
38
Is Le Fort I Osteotomy Associated With Maxillary Sinusitis? ( 26546843 )
2015
39
Large Haller cell mucocele leading to maxillary sinusitis. ( 25923288 )
2015
40
Etiologies and Treatments of Odontogenic Maxillary Sinusitis: A Systematic Review. ( 26756016 )
2015
41
IRAK4 gene polymorphism and odontogenic maxillary sinusitis. ( 25707370 )
2015
42
One stage combined endoscopic and per-oral buccal fat pad approach for large oro-antral-fistula closure with secondary chronic maxillary sinusitis. ( 26006724 )
2015
43
Antibiotics for acute maxillary sinusitis in adults. ( 24515610 )
2014
44
Long-term outcomes of endoscopic maxillary mega-antrostomy for refractory chronic maxillary sinusitis. ( 25312656 )
2014
45
Maxillary Sinusitis Caused by Dental Implants Extending into the Maxillary Sinus and the Nasal Cavities. ( 24417178 )
2014
46
Correlation between the rate of asymmetry volume of maxillary sinuses and clinical symptomatology in the silent sinus syndrome: A retrospective study about 13 cases. ( 26521368 )
2014
47
Odontogenic maxillary sinusitis: a review. ( 25209225 )
2014
48
Aperture width of the osteomeatal complex as a predictor of successful treatment of odontogenic maxillary sinusitis. ( 25042902 )
2014
49
Endoscopic sinus surgery in individuals with facial pain due to chronic maxillary sinusitis - a functional controlled study. ( 25003399 )
2014
50
Chronic maxillary sinusitis caused by root canal overfilling of Calcipex II. ( 24516832 )
2014

Variations for Maxillary Sinusitis

Expression for Maxillary Sinusitis

Search GEO for disease gene expression data for Maxillary Sinusitis.

Pathways for Maxillary Sinusitis

Pathways related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 CCL5 CD79A IRAK4 MPO
2 10.64 MPO SELP

GO Terms for Maxillary Sinusitis

Cellular components related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL5 IRAK4 MPO RNASE3 SELP

Biological processes related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.16 CCL5 SELP
2 positive regulation of smooth muscle cell proliferation GO:0048661 8.96 CCL5 IRAK4
3 leukocyte cell-cell adhesion GO:0007159 8.62 CCL5 SELP

Molecular functions related to Maxillary Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 RNASE3 SELP

Sources for Maxillary Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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