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MCID: MSL001
MIFTS: 61

Measles

Categories: Eye diseases, Infectious diseases, Mental diseases, Rare diseases, Skin diseases, Smell/Taste diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Measles

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MalaCards integrated aliases for Measles:

Name: Measles 12 74 20 29 54 42 3 44 15 17 71 32
Morbilli 12
Rubeola 20

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Skin diseases Eye diseases Smell/Taste diseases Mental diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8622
ICD9CM 34 055
MeSH 44 D008457
NCIt 50 C96406
SNOMED-CT 67 154338006
UMLS 71 C0025007
Sources

Summaries for Measles

About this section
MedlinePlus : 42 Measles is an infectious disease caused by a virus. It spreads easily from person to person. It causes a blotchy red rash. The rash often starts on the head and moves down the body. Other symptoms include Fever Cough Runny nose Conjunctivitis (pink eye) Feeling achy and run down Tiny white spots inside the mouth Sometimes measles can lead to serious problems. There is no treatment for measles, but the measles-mumps-rubella (MMR) vaccine can prevent it. "German measles", also known as rubella, is a completely different illness. Centers for Disease Control and Prevention

MalaCards based summary : Measles, also known as morbilli, is related to subacute sclerosing panencephalitis and rubella, and has symptoms including fever, cough and conjunctivitis. An important gene associated with Measles is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Viral mRNA Translation. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Measles virus, which is transmitted by contact with oronasal secretions, or semen of an infected person. The infection has symptom fever, has symptom cough, has symptom coryza, has symptom conjunctivitis, and has symptom maculopapular, erythematous rash.

CDC : 3 Measles is a highly contagious virus that can lead to complications.

Wikipedia : 74 Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop... more...

Sources

Related Diseases for Measles

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Diseases related to Measles via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 859)
# Related Disease Score Top Affiliating Genes
1 subacute sclerosing panencephalitis 32.5 TNF TLR3 SLAMF1 IL6 IL2 IFNA1
2 rubella 32.4 TNF TLR3 IL6 IL2 IFNB1 IFNAR2
3 mumps 31.8 TNF TLR3 STAT1 IL6 IL2 IFNB1
4 exanthem 31.7 TNF IL6 IL2 IFNA1 IFIH1
5 poliomyelitis 31.7 TNF TLR3 IFNA1 DDX58
6 encephalitis 31.5 TNF TLR3 TLR2 IL6 IFNB1 DDX58
7 chickenpox 31.4 TNF STAT1 IL6 IL2 IFNB1 IFNA1
8 conjunctivitis 31.3 TNF TLR3 IL6 IL2
9 tetanus 31.2 TNF IL6 IL2 HLA-A
10 myelitis 31.1 TNF IL6 IFNB1
11 haemophilus influenzae 31.0 TNF TLR2
12 yellow fever 31.0 STAT1 IL6 IFNB1 DDX58
13 appendicitis 31.0 TNF IL6 IL2
14 pneumonia 31.0 TNF TLR3 TLR2 IL6 IFNA1
15 disease by infectious agent 30.9 TNF TLR2 IL6 IL2 IFNB1 IFNA1
16 crohn's disease 30.9 TNF TLR2 IL6 IL2
17 diarrhea 30.9 TNF IL6 IL2 IFNB1 IFNA1
18 meningitis 30.9 TNF TLR2 IL6 IL2 CD46
19 hepatitis a 30.8 TNF TLR3 IFNA1
20 allergic disease 30.8 TNF TLR2 IL6 IL2
21 vaccinia 30.8 TNF STAT1 IL6 IL2 IFNB1 IFNA1
22 otitis media 30.8 TNF TLR2 IL6
23 bacterial infectious disease 30.7 TNF TLR3 TLR2 IL6 IFNB1
24 optic neuritis 30.7 TNF IL6 HLA-A
25 bronchitis 30.7 TNF TLR2 STAT1 IL6
26 covid-19 30.6 STAT1 IL6 IFNB1 IFNA1 IFIH1
27 dengue virus 30.6 TNF IFIH1 DDX58 CD209
28 newcastle disease 30.6 TNF TLR3 IFNB1 IFNA1 EIF2AK2 DDX58
29 hepatitis 30.6 TNF IFNAR2 IFNA1 IFIH1 EIF2AK2 DDX58
30 stomatitis 30.6 TNF IL6 IL2 IFNB1 IFNA1 EIF2AK2
31 gastroenteritis 30.6 TNF IL6 IFNA1
32 rabies 30.6 TLR3 STAT1 IFNA1 DDX58
33 inflammatory bowel disease 30.6 TNF TLR3 TLR2 STAT1 IL6 IL2
34 chikungunya 30.6 TNF STAT1 IL6 DDX58 CD209
35 bronchiolitis 30.5 TNF TLR3 TLR2 IL6 IFNA1
36 herpes simplex 30.5 TLR3 TLR2 STAT1 IFNB1 IFNA1 IFIH1
37 parainfluenza virus type 3 30.5 IFNB1 IFNA1 DDX58
38 west nile virus 30.5 IFNA1 IFIH1 DDX58 CD209
39 dengue disease 30.5 TNF IFNB1 IFNA1 CD209
40 myocarditis 30.5 TNF TLR3 IL6 IL2 IFNA1
41 bacterial pneumonia 30.5 TNF TLR2 IL6
42 acquired immunodeficiency syndrome 30.5 TNF IL6 IL2 IFNA1
43 otosclerosis 30.5 IL6 HLA-A CD46
44 dermatitis 30.5 TNF TLR2 STAT1 IL6 IL2
45 hepatitis b 30.5 TNF TLR3 TLR2 STAT1 IL6 IFNB1
46 kawasaki disease 30.5 TNF IL6 FCGR2B
47 erythema multiforme 30.5 TNF IL6 IL2
48 viral encephalitis 30.4 TNF TLR3 IL6 IFNB1 IFNA1
49 viral pneumonia 30.4 TNF TLR3 IL6 IFNB1 DDX58
50 orchitis 30.4 TNF IL6 IL2

Graphical network of the top 20 diseases related to Measles:



Diseases related to Measles
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Symptoms & Phenotypes for Measles

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Symptoms:

12
  • • fever
  • • cough
  • • conjunctivitis
  • • coryza
  • • maculopapular

UMLS symptoms related to Measles:


fever, pruritus, exanthema, koplik spots

MGI Mouse Phenotypes related to Measles:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 ADAR CD209 DDX58 EIF2AK2 FCGR2B HLA-A
2 immune system MP:0005387 10.22 ADAR DDX58 EIF2AK2 FCGR2B HLA-A IFIH1
3 homeostasis/metabolism MP:0005376 10.21 ADAR CD209 DDX58 FCGR2B IFIH1 IFNAR2
4 mortality/aging MP:0010768 10 ADAR DDX58 EIF2AK2 FCGR2B HLA-A IFIH1
5 liver/biliary system MP:0005370 9.91 ADAR DDX58 FCGR2B IFIH1 IL2 IL6
6 neoplasm MP:0002006 9.65 DDX58 EIF2AK2 IFNAR2 IFNB1 IL2 IL6
7 respiratory system MP:0005388 9.23 FCGR2B IL2 IL6 MSN STAT1 TLR2
Sources

Drugs & Therapeutics for Measles

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Drugs for Measles (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 4 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
3 Vaccines Phase 4
4 Citrate Phase 4
5 Immunologic Factors Phase 4
6 Liver Extracts Phase 4
7 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
8
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
9
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
10
Lactitol Approved, Investigational Phase 3 585-86-4 157355
11 Orange Approved Phase 3
12
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
13
Sulfamethoxazole Approved Phase 3 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Petrolatum Approved, Investigational Phase 3 8009-03-8
16
Podophyllin Approved Phase 3 9000-55-9
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
19 Fanasil, pyrimethamine drug combination Phase 3
20 Folic Acid Antagonists Phase 3
21 Vitamin B Complex Phase 3
22 Antiparasitic Agents Phase 3
23 Antiprotozoal Agents Phase 3
24 Vitamin B9 Phase 3
25 Antimalarials Phase 3
26 Folate Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
29 Micronutrients Phase 3
30 Trace Elements Phase 3
31 Retinol palmitate Phase 3
32 retinol Phase 3
33 Vitamins Phase 3
34 Nutrients Phase 3
35 taxane Phase 3
36 Hemagglutinins Phase 3
37 Somatomedin B Phase 3
38 Keratolytic Agents Phase 3
39 Dermatologic Agents Phase 3
40 Insulin, Globin Zinc Phase 3
41 insulin Phase 3
42
Altretamine Approved Phase 2 645-05-6 2123
43
BCG vaccine Approved, Investigational Phase 1, Phase 2
44
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
45
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
46
Gemcitabine Approved Phase 2 95058-81-4 60750
47
Bevacizumab Approved, Investigational Phase 2 216974-75-3
48
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
49
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
50
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067

Interventional clinical trials:

(show top 50) (show all 167)
# Name Status NCT ID Phase Drugs
1 A Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality and to Explore the Role of Maternal Measles Antibodies for the Beneficial Non-specific Effects of Measles Vaccine Unknown status NCT01486355 Phase 4
2 The Safety and Immunogenicity of Enterovirus Type 71 Inactivated Vaccine (Human Diploid Cell) With Two Measles Attenuated Live Vaccine and Live Attenuated Japanese Encephalitis Vaccine at the Same Time Point in Infants (8-month-old) Unknown status NCT03296410 Phase 4
3 A Cluster Randomized Controlled Trial on the Campaign Effect of Measles Vaccine and Oral Polio Vaccine on General Hospital Admissions and Mortality Among Children Unknown status NCT03460002 Phase 4
4 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01668745 Phase 4
5 A Two-site Randomised Trial of an Additional Measles Vaccine at 4 Months of Age to Reduce Child Mortality in Rural Areas of Burkina Faso and Guinea-Bissau Unknown status NCT01644721 Phase 4
6 The Effect on Overall Mortality of a National Policy of Limiting Measles Vaccination to Children Below 12 Months of Age Unknown status NCT01306006 Phase 4
7 Immunogenicity and Safety of AVAXIMâ„¢ 80U-Pediatric Administered Alone or Concomitantly With TRIMOVAXâ„¢ in 12-13 Months Old Healthy Hepatitis A Seronegative Turkish Children Completed NCT00313950 Phase 4
8 Assessing Immunogenicity of Measles-Rubella Vaccine at 6 and 9 Months of Age Completed NCT03071575 Phase 4
9 Measles Vaccination in Guinea-Bissau. Strategies to Reduce Disease Burden and Improve Child Survival Completed NCT00168558 Phase 4
10 Immunogenicity and Safety of Concurrent Administration of Live, Attenuated SA 14-14-2 Japanese Encephalitis Vaccine and Measles-Mumps-Rubella Vaccine in Infants 9-12 Months of Age in the Philippines Completed NCT02880865 Phase 4
11 Reactogenicity and Protectivity Following Measles- Rubella (MR) Routine Immunization in Indonesian Infants and Children Completed NCT03680417 Phase 4
12 Long-term Follow-up of Protective Measles Antibodies in the Two-dose Study of Standard-titre Measles Vaccine in Guinea-Bissau Completed NCT00168571 Phase 4
13 Search for the Measles Vaccine Virus Excretion in Breast Milk of Breastfeeding Women After Postpartum Vaccination With a Combined Measles-mumps-rubella (MMR) Vaccine Completed NCT02325310 Phase 4
14 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella), Single Dose and Multidose Presentations in Children 12 to 23 Months of Age. Completed NCT01777529 Phase 4
15 Immunogenicity of Co-administration of Measles Containing Vaccine and Japanese Encephalitis Alive Vaccines Completed NCT02643433 Phase 4
16 Trial of Two-Dose Standard Measles Vaccination Schedule: Long-Term Impact on Morbidity and Mortality of a Two-Dose Vaccination Schedule at 6 and 9 Months of Age Compared With a Standard Regimen of One Dose at 9 Months of Age Completed NCT00168662 Phase 4
17 Non-specific Effects of Vaccines - In Search of the Immunological Background Completed NCT00168545 Phase 4
18 Comparison of Immunization Schedules of Beijing Tiantan Biological's MMR Vaccine in 18-72 Month-Old Children Completed NCT03160820 Phase 4
19 Non-interference and Safety of Concomitant Administration of Measles-rubella and Rotavirus Vaccines at 9 Months of Age in Rural Bangladesh Completed NCT01700621 Phase 4
20 Multicenter Randomized Clinical Trial in Patients With Juvenile Idiopathic Arthritis: Safety and Efficacy of Vaccination With Live Attenuated Measles, Mumps, Rubella Vaccine Completed NCT00731965 Phase 4
21 An Evaluation of the Immune Response to Pentavalent Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
22 Phase IV Open Study to Assess the Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-Mumps-Rubella (MMR) Vaccine When Given to Healthy Children at the Age of 12 to 18 Months in Singapore. Completed NCT00388440 Phase 4
23 Diphteria-tetanus-pertussis (DTP) Vaccination and Child Survival: Randomized Study of Not Providing DTP Vaccination Together With or After Measles Vaccination Completed NCT00244673 Phase 4
24 Blinded, Randomised Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Live Attenuated Measles-mumps-rubella-varicella Candidate Vaccine When Given to Healthy Children in Their Second Year of Life Completed NCT00126997 Phase 4
25 Seroprevalence of Antibodies to Measles, Mumps, and Rubella, and Serologic Responses After Vaccination Among Human Immunodeficiency Virus (HIV)-1 Infected Adults in Northern Thailand Completed NCT02724852 Phase 4
26 A Phase 4, Randomized Trial to Assess the Safety and Immunogenicity of Inactivated Poliovirus Vaccine When Given Concomitantly With Measles and Rubella Combined Vaccine and Yellow Fever Vaccine at Nine Months and When Administered Via Different Vaccination Routes Completed NCT01847872 Phase 4 IPV IM Needle;IPV ID Needle;IPV IM Device;IPV ID Device
27 Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts : a Randomized Controlled Trial Completed NCT03183765 Phase 4 Measles-Mumps-Rubella Vaccine
28 Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines in Children Under 2 Years Old in Argentina Completed NCT03368495 Phase 4
29 A Double-blind, Randomised, Controlled, Multi-centre Safety Study of a Refrigerator-stable Formulation of VARIVAX® in Healthy 12 to 15 Month-old Infants. Completed NCT00432731 Phase 4
30 An Open, Multicenter Study of the Safety and Tolerability of VAQTA(TM) and ProQuad(TM) in Healthy Children 12 to 23 Months of Age Completed NCT00326183 Phase 4
31 Induction and Maintenance of Immunity Against Measles in Pediatric Orthotopic Liver Transplantation Recipients: a Prospective Nationwide Study in Switzerland Recruiting NCT01770119 Phase 4
32 Health Effects of Utilising Curative Health System Contacts to Provide Measles Vaccination - a Randomised Controlled Trial Recruiting NCT04220671 Phase 4
33 Randomized, Double-blind, Controlled Phase â…£ Clinical Trial to Evaluate the Safety and Immunogenicity of Mumps Vaccine in Healthy Infants Aged 8 ~12 Months. Recruiting NCT04364399 Phase 4
34 A Randomized, Controlled, Multicenter Phase 4 Clinic Trial to Evaluate the Immunogenicity and Safety of Combined Immunization of Sabin-strain Inactivated Polio Vaccine (sIPV), Diphtheria, Tetanus, Pertussis Vaccine (DTaP) and Measles, Moms and Rubella Vaccine (MMR) Recruiting NCT04638985 Phase 4
35 Measles-mumps-rubella Vaccine at 6 Months of Age, Immunology, and Childhood Morbidity in a High-income Setting Recruiting NCT03780179 Phase 4
36 A Randomized, Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With Measles, Mumps, and Rubella Combined Live Attenuated Vaccine/ Encephalitis Live Attenuated Vaccine Recruiting NCT04111432 Phase 4
37 Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine in HIV-exposed and HIV-unexposed South African Children Active, not recruiting NCT03330171 Phase 4
38 Community Effectiveness of Intermittent Preventive Treatment Delivered Through the Expanded Programme of Immunisation for Malaria and Anaemia Control in Tanzanian Infants Unknown status NCT00152204 Phase 3 Sulfadoxine-pyrimethamine used for IPTi;IPTi
39 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
40 A Phase 3, Open-Label, Randomized, Multi-Center Study to Evaluate the Safety and Immunogenicity of MMRV Vaccine When Administered Concomitantly With Novartis Meningococcal ACWY Conjugate Vaccine to Healthy Toddlers Completed NCT00626327 Phase 3
41 Assessment of the Non-Inferiority of the Concurrent Administration of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine and Measles Vaccine Given Alone Completed NCT00249769 Phase 3
42 A Phase III Double-Blind, Randomized, Multicenter, Controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP) Completed NCT01536405 Phase 3
43 Long-Term Assessment at 24 Months Post-Vaccination of the Non-Inferiority of the Concurrent Administration of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine and Measles Vaccine to Measles Vaccine Given Alone Completed NCT00412516 Phase 3
44 An Open-label, Randomised, Comparative, Multi-centre Study of the Immunogenicity and Safety of a 2-dose Regimen of ProQuad® Manufactured With rHA Administered to Healthy Children From 9 Months of Age Completed NCT00566527 Phase 3
45 An Open-label, Multi-centre Study of the Safety of a 2-dose Regimen of a Combined Measles, Mumps, Rubella and Varicella Live Vaccine (ProQuad®) Manufactured With Recombinant Human Albumin (rHA) When Administered to Children in Their Second Year of Life Completed NCT00560755 Phase 3
46 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
47 Open, Multicenter, Randomised, Controlled Phase IIIb Study Evaluating the Immunogenicity and Safety of Subcutaneous Versus Alternative Administration Route of Combined MeMuRu-OKA Vaccine to Healthy Children Aged 11 to 21 Months. Completed NCT00351923 Phase 3
48 A Comparison of the Safety, Tolerability, and Immunogenicity of a Refrigerator-Stable Measles, Mumps, Rubella, and Varicella Combination Vaccine V221 (Refrigerated) Versus V221 (Frozen) in Healthy Children Completed NCT00092430 Phase 3
49 Safety and Immunogenicity Study of GSK Biologicals' Measles-mumps-rubella (MMR) Vaccine (209762) Comparing Immunogenicity and Safety to Merck & Co., Inc.'s MMR Vaccine, in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
50 An Open, Randomised, Comparative, Multicentre Study of the Immunogenicity and Safety of M-M-Râ„¢II Manufactured With Recombinant Human Albumin (rHA) and VARIVAX® When Administered Concomitantly by Intramuscular (IM) Route or Subcutaneous (SC) Route at Two Separate Injection Sites in Healthy Subjects 12 to 18 Months of Age Completed NCT00432523 Phase 3

Search NIH Clinical Center for Measles

Cochrane evidence based reviews: measles

Sources

Genetic Tests for Measles

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Genetic tests related to Measles:

# Genetic test Affiliating Genes
1 Measles 29
Sources

Anatomical Context for Measles

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The Foundational Model of Anatomy Ontology organs/tissues related to Measles:

19
Skin

MalaCards organs/tissues related to Measles:

40
T Cells, Bone Marrow, Eye, Kidney, Skin, Endothelial, Breast
Sources

Publications for Measles

About this section

Articles related to Measles:

(show top 50) (show all 23772)
# Title Authors PMID Year
1
Reply to Marakasova and Baranova, "MMR Vaccine and COVID-19: Measles Protein Homology May Contribute to Cross-Reactivity or to Complement Activation Protection". 61 42
33531392 2021
2
Utilization of the Public Health Ordinance to prevent nosocomial spread in a case of acute measles-associated psychosis. 61 42
33451324 2021
3
Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten - United States, 2019-20 School Year. 61 42
33476312 2021
4
Measles virus-induced immunosuppression in SLAM knock-in mice. 54 61
20200244 2010
5
Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. 54 61
20071568 2010
6
Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). 54 61
20042501 2010
7
Development and evaluation of a rapid immunochromatographic test for mumps-specific IgM in oral fluid specimens and use as a matrix for preserving viral nucleic acid for RT-PCR. 61 54
20087926 2010
8
Restriction analysis of otosclerosis-associated CD46 splicing variants. 61 54
19597833 2010
9
Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor. 61 54
19806178 2009
10
Laboratory confirmation of measles in elimination settings: experience from the Republic of the Marshall Islands, 2003. 61 54
19274360 2009
11
Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis. 61 54
19319188 2009
12
Inhibition of IFN-alpha/beta signaling by two discrete peptides within measles virus V protein that specifically bind STAT1 and STAT2. 54 61
19007958 2009
13
Disease-associated novel CD46 splicing variants and pathologic bone remodeling in otosclerosis. 54 61
18677279 2008
14
Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. 54 61
18715339 2008
15
Measles virus induces oncolysis of mesothelioma cells and allows dendritic cells to cross-prime tumor-specific CD8 response. 61 54
18559536 2008
16
Effects of interleukin-12 and interleukin-15 on measles-specific T-cell responses in vaccinated infants. 61 54
18419254 2008
17
High-density rafts preferentially host the complement activator measles virus F glycoprotein but not the regulators of complement activation. 61 54
18455798 2008
18
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. 54 61
18325643 2008
19
[Host genetic factors for the development of SSPE]. 54 61
17695285 2007
20
Adenovirus type 5 substituted with type 11 or 35 fiber structure increases its infectivity to human cells enabling dual gene transfer in CD46-dependent and -independent manners. 54 61
17695519 2007
21
Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination. 54 61
17492596 2007
22
Expression of measles virus receptors in otosclerotic, non-otosclerotic and in normal stapes footplates. 54 61
17294206 2007
23
Downregulation of human CD46 by adenovirus serotype 35 vectors. 54 61
17377598 2007
24
Current problems of measles control in Japan and Western Pacific Region. 54 61
17368662 2007
25
Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response. 61 54
17356690 2007
26
Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection. 61 54
17135325 2007
27
Measles virus-dendritic cell interaction via SLAM inhibits innate immunity: selective signaling through TLR4 but not other TLRs mediates suppression of IL-12 synthesis. 61 54
17070884 2007
28
Detection of circulating antigen with a MAb-based sandwich-ELISA and its comparison with specific IgM detection in sera of patients with hemorrhagic fever with renal syndrome. 61 54
17316085 2007
29
A case of common variable immunodeficiency syndrome associated with Takayasu arteritis. 61 54
17304891 2007
30
Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma. 61 54
17133484 2006
31
Cloning, expression, and purification of a highly immunogenic recombinant gonadotropin-releasing hormone (GnRH) chimeric peptide. 54 61
17064933 2006
32
The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancer. 54 61
17062694 2006
33
Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. 61 54
16645169 2006
34
The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines. 54 61
16782388 2006
35
Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM). 61 54
16889684 2006
36
Oncolytic measles virus targets high CD46 expression on multiple myeloma cells. 61 54
16728275 2006
37
Assessment of the performance of a definition of a suspected measles case: implications for measles surveillance. 54 61
16723063 2006
38
Immunosuppression caused by measles virus: role of viral proteins. 54 61
16237742 2006
39
Alterations in cell-mediated immune response in subacute sclerosing panencephalitis. 61 54
16223530 2005
40
Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice. 61 54
16260741 2005
41
CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion. 61 54
15920733 2005
42
Evaluation of diagnostic markers for measles virus infection in the context of an outbreak in Spain. 61 54
16207972 2005
43
Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays. 54 61
16036810 2005
44
Localization of regions in CD46 that interact with adenovirus. 61 54
15919905 2005
45
CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cells. 61 54
15845515 2005
46
Rescue and propagation of fully retargeted oncolytic measles viruses. 54 61
15685166 2005
47
Probing neutralizing-antibody responses against emerging measles viruses (MVs): immune selection of MV by H protein-specific antibodies? 54 61
15659756 2005
48
Expression of the interferon-alpha/beta-inducible MxA protein in brain lesions of subacute sclerosing panencephalitis. 54 61
15337611 2004
49
Measles virus receptors: SLAM and CD46. 61 54
15248250 2004
50
Variation in vaccine response in normal populations. 61 54
15165177 2004
Sources

Variations for Measles

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Sources

Expression for Measles

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Search GEO for disease gene expression data for Measles.
Sources

Pathways for Measles

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Pathways related to Measles according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.96 TNF TLR3 TLR2 STAT1 IL6 IL2
2
Viral mRNA Translation 65
Show member pathways
 13.84 TNF TLR3 TLR2 STAT1 IL6 IL2
3
TGF-Beta Pathway 63
Show member pathways
 13.54 TNF STAT1 IL6 IL2 IFNB1 IFNAR2
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.4 TNF STAT1 IL6 IL2 IFNB1 IFNAR2
5
Human cytomegalovirus infection 36
Show member pathways
 12.98 TNF TLR3 TLR2 STAT1 IL6 IFNB1
6
Allograft rejection 36 1
Show member pathways
 12.88 TNF STAT1 IL6 IL2 IFNA1 HLA-A
7
Pathways in cancer 36
12.83 STAT1 IL6 IL2 IFNAR2 IFNA1
8
PI3K-Akt signaling pathway 36
Show member pathways
 12.83 TNF TLR3 TLR2 STAT1 IL6 IL2
9
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.82 TNF TLR3 TLR2 STAT1 IL6 IL2
10
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.78 TNF TLR3 TLR2 STAT1 IL6 IFNB1
11
NF-KappaB Family Pathway 63
Show member pathways
 12.75 TNF TLR3 TLR2 IL6 IL2 EIF2AK2
12
T cell receptor signaling pathway 36
Show member pathways
 12.63 TNF TLR2 STAT1 IL6 IL2
13
Interferon gamma signaling 65
Show member pathways
 12.63 STAT1 IFNB1 IFNAR2 IFNA1 HLA-A EIF2AK2
14
Th17 cell differentiation 36
Show member pathways
 12.62 TNF TLR2 STAT1 IL6 IL2
15
Cytosolic sensors of pathogen-associated DNA 65
Show member pathways
 12.62 TLR3 IL6 IFNB1 IFNA1 IFIH1 DDX58
16
Immune response IL-23 signaling pathway 23
Show member pathways
 12.61 TNF STAT1 IL6 IL2 EIF2AK2
17
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.58 TNF IL2 IFNB1 IFNAR2 IFNA1 HLA-A
18
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.57 TNF IFNB1 IFNA1 IFIH1 DDX58
19
NF-kappaB Signaling 4
12.54 TNF TLR3 TLR2 STAT1 IL2 IFNA1
20
JAK-STAT signaling pathway 36
Show member pathways
 12.49 STAT1 IL6 IL2 IFNB1 IFNAR2 IFNA1
21
Herpes simplex virus 1 infection 36
12.43 TNF TLR3 TLR2 STAT1 IL6 IFNB1
22
Human T-cell leukemia virus 1 infection 36
12.34 TNF IL6 IL2 HLA-A
23
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.33 TNF TLR3 TLR2 IL6 IFNB1
24
Toll Comparative Pathway 63
Show member pathways
 12.31 TNF TLR3 STAT1 IL6
25
NOD-like receptor signaling pathway 36
12.31 TNF STAT1 IL6 IFNB1 IFNAR2 IFNA1
26
Measles 36
Show member pathways
 12.31 TNF TLR3 TLR2 STAT1 SLAMF1 MSN
27
Necroptosis 36
Show member pathways
 12.3 TNF TLR3 STAT1 IFNB1 IFNAR2 IFNA1
28
C-type lectin receptor signaling pathway 36
Show member pathways
 12.28 TNF STAT1 IL6 IL2 CD209
29
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.27 TNF STAT1 IL6 IL2 IFNB1 IFNAR2
30
Colorectal Cancer Metastasis 63
12.26 TNF TLR3 TLR2 STAT1 IL6
31
Bacterial infections in CF airways 23
Show member pathways
 12.25 TNF TLR2 STAT1 IL6 IFNB1
32
Tuberculosis 36
12.18 TNF TLR2 STAT1 IL6 IFNB1 IFNA1
33
Phagosome 36
12.16 TLR2 HLA-A FCGR2B CD209
34
Osteoclast differentiation 36
12.13 TNF STAT1 IFNB1 IFNAR2 FCGR2B
35
Yersinia infection 36
12.11 TNF IL6 IL2 IFNB1
36
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.07 TNF SLAMF1 IL6 IL2 CD209
37
MAPK Pathway 70
Show member pathways
 12.06 TLR3 TLR2 STAT1 IL2
38
Interferon Pathway 63
11.96 STAT1 IL6 IFNB1 IFNAR2 IFNA1
39
Th17 Differentiation Pathway 64
Show member pathways
 11.92 TLR3 TLR2 STAT1 IL6
40
Th1 Differentiation Pathway 64
Show member pathways
 11.87 TNF TLR3 TLR2 STAT1 IL6 IL2
41
Dendritic Cells Developmental Lineage Pathway 64
11.84 TNF SLAMF1 IL6 IL2 IFNB1 CD209
42
Glucocorticoid receptor regulatory network 1
11.8 STAT1 IL6 IL2
43
IgA-Producing B Cells in the Intestine 64
11.78 TNF TLR2 SLAMF1 IL6 FCGR2B
44
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.72 TNF IL2 IFNAR2 HLA-A
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 TNF IL6 IL2
46
Legionellosis 36
11.63 TNF TLR2 IL6
47
Photodynamic therapy-induced AP-1 survival signaling. 1
11.58 TNF IL6 IL2
48
Malaria 36
11.57 TNF TLR2 IL6
49
all-trans-Retinoic Acid Mediated Apoptosis 63
11.54 IL6 IFNB1 IFNA1
50
Type II interferon signaling (IFNG) 1
11.41 STAT1 IFNB1 EIF2AK2
Sources

GO Terms for Measles

About this section

Cellular components related to Measles according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TNF SLAMF1 NECTIN4 IL6 IL2 IFNB1
2 cell surface GO:0009986 9.23 TNF TLR3 TLR2 SLAMF1 MSN HLA-A

Biological processes related to Measles according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 TNF TLR3 TLR2 STAT1 IL6 IL2
2 positive regulation of gene expression GO:0010628 10.14 TNF TLR3 TLR2 MSN IL6 DDX58
3 immune response GO:0006955 10.13 TNF TLR3 TLR2 IL6 IL2 HLA-A
4 adaptive immune response GO:0002250 10.12 SLAMF1 IL2 IFNB1 IFNA1 HLA-A CD46
5 inflammatory response GO:0006954 10.08 TNF TLR3 TLR2 IL6 FCGR2B
6 cytokine-mediated signaling pathway GO:0019221 10.05 TNF STAT1 IL6 IL2 IFNB1 IFNAR2
7 innate immune response GO:0045087 10.02 TLR3 TLR2 SLAMF1 IFIH1 HLA-A EIF2AK2
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.01 TNF TLR3 TLR2 IL6 EIF2AK2
9 immune system process GO:0002376 10 TLR3 TLR2 SLAMF1 IL2 IFIH1 HLA-A
10 defense response GO:0006952 9.97 TNF TLR3 STAT1 IFNB1 IFNA1 FCGR2B
11 defense response to Gram-positive bacterium GO:0050830 9.96 TNF TLR2 IL6 HLA-A
12 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR3 TLR2 IL2
13 viral entry into host cell GO:0046718 9.94 SLAMF1 NECTIN4 CD46 CD209
14 positive regulation of JNK cascade GO:0046330 9.93 TNF TLR3 SLAMF1 FCGR2B
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.93 TNF TLR3 TLR2 EIF2AK2
16 positive regulation of tumor necrosis factor production GO:0032760 9.93 TLR3 TLR2 IL6 IFIH1 DDX58
17 positive regulation of interferon-gamma production GO:0032729 9.92 TNF TLR3 IL2 HLA-A
18 positive regulation of T cell proliferation GO:0042102 9.92 IL6 IL2 CD46 CD209
19 humoral immune response GO:0006959 9.91 TNF IL6 IFNB1 IFNA1
20 viral process GO:0016032 9.9 STAT1 SLAMF1 NECTIN4 MSN IFIH1 HLA-A
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 TNF IL6 IL2
22 positive regulation of interleukin-6 production GO:0032755 9.88 TNF TLR3 TLR2 IL6 IFIH1 DDX58
23 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF STAT1 IL6
24 positive regulation of interferon-beta production GO:0032728 9.87 TLR3 TLR2 IFIH1 DDX58
25 positive regulation of cytokine production GO:0001819 9.86 TNF TLR3 EIF2AK2
26 response to exogenous dsRNA GO:0043330 9.86 TLR3 IFNB1 IFNA1 DDX58
27 negative regulation of viral genome replication GO:0045071 9.85 TNF IFNB1 EIF2AK2
28 positive regulation of interleukin-10 production GO:0032733 9.85 TLR2 IL6 CD46
29 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR3 TLR2 IL6 DDX58
30 type I interferon signaling pathway GO:0060337 9.85 STAT1 IFNB1 IFNAR2 IFNA1 HLA-A ADAR
31 microglial cell activation GO:0001774 9.84 TNF TLR3 TLR2
32 positive regulation of interferon-alpha production GO:0032727 9.83 TLR3 STAT1 IFIH1 DDX58
33 positive regulation of chemokine production GO:0032722 9.83 TNF TLR3 TLR2 IL6 EIF2AK2
34 cellular response to interferon-beta GO:0035458 9.81 TLR3 STAT1 IFNB1
35 cellular response to exogenous dsRNA GO:0071360 9.78 TLR3 IFNB1 IFIH1 DDX58
36 response to interferon-alpha GO:0035455 9.77 IFNAR2 EIF2AK2 ADAR
37 detection of virus GO:0009597 9.72 TLR3 IFIH1 DDX58
38 positive regulation of neuroinflammatory response GO:0150078 9.71 TNF IL6
39 I-kappaB phosphorylation GO:0007252 9.71 TLR3 TLR2
40 positive regulation of podosome assembly GO:0071803 9.71 TNF MSN
41 response to interferon-beta GO:0035456 9.7 STAT1 IFNAR2
42 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
43 necroptotic signaling pathway GO:0097527 9.7 TNF TLR3
44 positive regulation of response to cytokine stimulus GO:0060760 9.69 IFIH1 DDX58
45 vascular endothelial growth factor production GO:0010573 9.69 TNF IL6
46 positive regulation of toll-like receptor signaling pathway GO:0034123 9.68 TLR3 TLR2
47 interleukin-10 production GO:0032613 9.67 TLR2 CD46
48 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.66 IFIH1 DDX58
49 regulation of type III interferon production GO:0034344 9.65 IFIH1 DDX58
50 response to virus GO:0009615 9.56 TNF TLR3 IFNB1 IFNAR2 IFIH1 EIF2AK2

Molecular functions related to Measles according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.32 TNF TLR3 TLR2 STAT1 SLAMF1 NECTIN4
2 identical protein binding GO:0042802 9.91 TNF TLR3 TLR2 STAT1 SLAMF1 NECTIN4
3 transmembrane signaling receptor activity GO:0004888 9.71 TLR3 TLR2 SLAMF1 FCGR2B
4 signaling receptor activity GO:0038023 9.67 TLR3 TLR2 SLAMF1 CD46
5 cytokine activity GO:0005125 9.55 TNF IL6 IL2 IFNB1 IFNA1
6 virus receptor activity GO:0001618 9.26 SLAMF1 NECTIN4 CD46 CD209
7 double-stranded RNA binding GO:0003725 9.1 TLR3 MSN IFIH1 EIF2AK2 DDX58 ADAR
Sources

Sources for Measles

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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