MCID: MCH001
MIFTS: 18

Mechanical Ectropion

Categories: Skin diseases

Aliases & Classifications for Mechanical Ectropion

MalaCards integrated aliases for Mechanical Ectropion:

Name: Mechanical Ectropion 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1569
ICD9CM 34 374.12
SNOMED-CT 67 45020000
UMLS 71 C0155194

Summaries for Mechanical Ectropion

MalaCards based summary : Mechanical Ectropion is related to optic nerve neoplasm and elephantiasis. An important gene associated with Mechanical Ectropion is NFIC (Nuclear Factor I C), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mechanical Ectropion

Diseases related to Mechanical Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 optic nerve neoplasm 10.0 NFIC NF1
2 elephantiasis 10.0 NFIC NF1
3 ectropion 10.0
4 plexiform neurofibroma 10.0 NFIC NF1
5 epithelioid neurofibroma 10.0 NF1 CD34
6 neurofibroma 9.9 NF1 CD34
7 neurilemmomatosis 9.9 NFIC NF1
8 fibroma 9.9 NF1 CD34
9 pacinian tumor 9.9 NF1 CD34
10 plexiform schwannoma 9.9 NF1 CD34
11 small intestine leiomyoma 9.9 NF1 CD34
12 atypical neurofibroma 9.9 NF1 CD34
13 orbital cancer 9.9 NF1 CD34
14 cellular schwannoma 9.9 NF1 CD34
15 epithelioid malignant peripheral nerve sheath tumor 9.9 NF1 CD34
16 malignant peripheral nerve sheath tumor 9.9 NF1 CD34
17 adult malignant schwannoma 9.9 NF1 CD34
18 subungual glomus tumor 9.9 NF1 CD34
19 malignant spindle cell melanoma 9.9 NF1 CD34
20 adult xanthogranuloma 9.9 NF1 CD34
21 exophthalmos 9.9 NF1 CD34
22 paraganglioma and gastric stromal sarcoma 9.9 NF1 CD34
23 cardiovascular cancer 9.9 NF1 CD34
24 connective tissue benign neoplasm 9.9 NF1 CD34
25 neurilemmoma 9.9 NF1 CD34
26 central nervous system benign neoplasm 9.9 NF1 CD34
27 lipomatosis, multiple 9.9 NF1 CD34
28 giant cell glioblastoma 9.9 NF1 CD34
29 skeletal muscle cancer 9.8 NF1 CD34
30 rhinosporidiosis 9.8
31 muscle cancer 9.8 NF1 CD34
32 skin benign neoplasm 9.8 NF1 CD34
33 cardiovascular organ benign neoplasm 9.8 NF1 CD34
34 neuroma 9.8 NF1 CD34
35 sarcoma, synovial 9.8 NF1 CD34
36 gliosarcoma 9.8 NF1 CD34
37 peripheral nervous system neoplasm 9.7 NF1 CD34
38 mucosal melanoma 9.7 NF1 IFNA2
39 chronic neutrophilic leukemia 9.7 IFNA2 CD34
40 vascular cancer 9.7 IFNA2 CD34
41 lymphangioma 9.6 IFNA2 CD34
42 mastocytosis, cutaneous 9.6 IFNA2 CD34
43 neurofibrosarcoma 9.6 NFIC NF1 CD34
44 melanoma, cutaneous malignant 1 9.5 NF1 IFNA2
45 meningioma, familial 9.5 NF1 CD34
46 acquired immunodeficiency syndrome 9.5 IFNA2 CD34
47 myeloproliferative neoplasm 9.5 NF1 IFNA2
48 hemangioma 9.4 IFNA2 CD34
49 leukemia, chronic myeloid 9.3 NF1 IFNA2 CD34
50 myelofibrosis 9.2 IFNA2 CD34

Comorbidity relations with Mechanical Ectropion via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Mechanical Ectropion:



Diseases related to Mechanical Ectropion

Symptoms & Phenotypes for Mechanical Ectropion

GenomeRNAi Phenotypes related to Mechanical Ectropion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.1 NFIC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.1 NFIC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.1 NFIC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.1 NFIC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 9.1 IFNA2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.1 IFNA2

Drugs & Therapeutics for Mechanical Ectropion

Search Clinical Trials , NIH Clinical Center for Mechanical Ectropion

Genetic Tests for Mechanical Ectropion

Anatomical Context for Mechanical Ectropion

MalaCards organs/tissues related to Mechanical Ectropion:

40
Skin

Publications for Mechanical Ectropion

Articles related to Mechanical Ectropion:

(show all 11)
# Title Authors PMID Year
1
A rare case of conjunctival malignant melanoma with orbital invasion. 61
31523071 2019
2
IgG4-Related Disease of the Punctum and Canaliculus. 61
26866331 2017
3
"Dry Lake" technique for the treatment of hypertrophic bleb following XEN(®) Gel Stent placement. 61
26008922 2015
4
Giant mass conjunctival rhinosporidiosis causing severe mechanical ectropion. 61
23360029 2012
5
Multiple apocrine hidrocystomas of the eyelids. 61
22489861 2012
6
Ectropion. 61
20590414 2010
7
Hemangiopericytoma-solitary fibrous tumor of the eyelid. 61
20090488 2010
8
Selective embolization and resection of a large noninvoluting congenital hemangioma of the lower eyelid. 61
19300152 2009
9
[Eyelid ectropion in Down's syndrome related to allergic conjunctivitis: case report]. 61
17906771 2007
10
Drug-induced ectropion: what is best practice? 61
17270684 2007
11
Mechanical ectropion repair using tarsal rotation sutures. 61
386207 1979

Variations for Mechanical Ectropion

Expression for Mechanical Ectropion

Search GEO for disease gene expression data for Mechanical Ectropion.

Pathways for Mechanical Ectropion

Pathways related to Mechanical Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 IFNA2 CD34
2 10.49 IFNA2 CD34

GO Terms for Mechanical Ectropion

Sources for Mechanical Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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