Mechanical Ectropion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mechanical Ectropion

MalaCards integrated aliases for Mechanical Ectropion:

Name: Mechanical Ectropion ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1569

ICD9CM ³⁴ 374.12

SNOMED-CT ⁶⁷ 45020000

UMLS ⁷¹ C0155194

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Summaries for Mechanical Ectropion

MalaCards based summary : Mechanical Ectropion is related to optic nerve neoplasm and elephantiasis. An important gene associated with Mechanical Ectropion is NFIC (Nuclear Factor I C), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Mechanical Ectropion

Diseases related to Mechanical Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)

#	Related Disease	Score	Top Affiliating Genes
1	optic nerve neoplasm	10.0	NFIC NF1
2	elephantiasis	10.0	NFIC NF1
3	ectropion	10.0
4	plexiform neurofibroma	10.0	NFIC NF1
5	epithelioid neurofibroma	10.0	NF1 CD34
6	neurofibroma	9.9	NF1 CD34
7	neurilemmomatosis	9.9	NFIC NF1
8	fibroma	9.9	NF1 CD34
9	pacinian tumor	9.9	NF1 CD34
10	plexiform schwannoma	9.9	NF1 CD34
11	small intestine leiomyoma	9.9	NF1 CD34
12	atypical neurofibroma	9.9	NF1 CD34
13	orbital cancer	9.9	NF1 CD34
14	cellular schwannoma	9.9	NF1 CD34
15	epithelioid malignant peripheral nerve sheath tumor	9.9	NF1 CD34
16	malignant peripheral nerve sheath tumor	9.9	NF1 CD34
17	adult malignant schwannoma	9.9	NF1 CD34
18	subungual glomus tumor	9.9	NF1 CD34
19	malignant spindle cell melanoma	9.9	NF1 CD34
20	adult xanthogranuloma	9.9	NF1 CD34
21	exophthalmos	9.9	NF1 CD34
22	paraganglioma and gastric stromal sarcoma	9.9	NF1 CD34
23	cardiovascular cancer	9.9	NF1 CD34
24	connective tissue benign neoplasm	9.9	NF1 CD34
25	neurilemmoma	9.9	NF1 CD34
26	central nervous system benign neoplasm	9.9	NF1 CD34
27	lipomatosis, multiple	9.9	NF1 CD34
28	giant cell glioblastoma	9.9	NF1 CD34
29	skeletal muscle cancer	9.8	NF1 CD34
30	rhinosporidiosis	9.8
31	muscle cancer	9.8	NF1 CD34
32	skin benign neoplasm	9.8	NF1 CD34
33	cardiovascular organ benign neoplasm	9.8	NF1 CD34
34	neuroma	9.8	NF1 CD34
35	sarcoma, synovial	9.8	NF1 CD34
36	gliosarcoma	9.8	NF1 CD34
37	peripheral nervous system neoplasm	9.7	NF1 CD34
38	mucosal melanoma	9.7	NF1 IFNA2
39	chronic neutrophilic leukemia	9.7	IFNA2 CD34
40	vascular cancer	9.7	IFNA2 CD34
41	lymphangioma	9.6	IFNA2 CD34
42	mastocytosis, cutaneous	9.6	IFNA2 CD34
43	neurofibrosarcoma	9.6	NFIC NF1 CD34
44	melanoma, cutaneous malignant 1	9.5	NF1 IFNA2
45	meningioma, familial	9.5	NF1 CD34
46	acquired immunodeficiency syndrome	9.5	IFNA2 CD34
47	myeloproliferative neoplasm	9.5	NF1 IFNA2
48	hemangioma	9.4	IFNA2 CD34
49	leukemia, chronic myeloid	9.3	NF1 IFNA2 CD34
50	myelofibrosis	9.2	IFNA2 CD34

Comorbidity relations with Mechanical Ectropion via Phenotypic Disease Network (PDN):

Facial Paralysis

Graphical network of the top 20 diseases related to Mechanical Ectropion:

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Symptoms & Phenotypes for Mechanical Ectropion

GenomeRNAi Phenotypes related to Mechanical Ectropion according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-105	9.1	NFIC
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-115	9.1	NFIC
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-116	9.1	NFIC
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-127	9.1	NFIC
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-178	9.1	IFNA2
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-20	9.1	IFNA2

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Drugs & Therapeutics for Mechanical Ectropion

Search Clinical Trials , NIH Clinical Center for Mechanical Ectropion

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Genetic Tests for Mechanical Ectropion

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Anatomical Context for Mechanical Ectropion

MalaCards organs/tissues related to Mechanical Ectropion:

⁴⁰

Skin

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Publications for Mechanical Ectropion

Articles related to Mechanical Ectropion:

(show all 11)

#	Title	Authors	PMID	Year
1	A rare case of conjunctival malignant melanoma with orbital invasion. ⁶¹	Rajbhandari Y...Joshi P	31523071	2019
2	IgG4-Related Disease of the Punctum and Canaliculus. ⁶¹	Silverman N...Shinder R	26866331	2017
3	"Dry Lake" technique for the treatment of hypertrophic bleb following XEN(®) Gel Stent placement. ⁶¹	Fernandez-Garcia A...Garzon N	26008922	2015
4	Giant mass conjunctival rhinosporidiosis causing severe mechanical ectropion. ⁶¹	Mandal SK...Biswas BK	23360029	2012
5	Multiple apocrine hidrocystomas of the eyelids. ⁶¹	Smith RJ...Reviglio VE	22489861	2012
6	Ectropion. ⁶¹	Bedran EG...Bernardes TF	20590414	2010
7	Hemangiopericytoma-solitary fibrous tumor of the eyelid. ⁶¹	Kakizaki H...Chan WO	20090488	2010
8	Selective embolization and resection of a large noninvoluting congenital hemangioma of the lower eyelid. ⁶¹	Ooi KG...Wilcsek GA	19300152	2009
9	[Eyelid ectropion in Down's syndrome related to allergic conjunctivitis: case report]. ⁶¹	Shiratori CA...Cvintal T	17906771	2007
10	Drug-induced ectropion: what is best practice? ⁶¹	Hegde V...Ahluwalia H	17270684	2007
11	Mechanical ectropion repair using tarsal rotation sutures. ⁶¹	Kohn R	386207	1979

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Genes for Mechanical Ectropion

Genes related to Mechanical Ectropion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NFIC	Nuclear Factor I C	Protein Coding	5.47	DISEASES inferred ¹⁵
2	CD34	CD34 Molecule	Protein Coding	4.91	DISEASES inferred ¹⁵
3	IFNA2	Interferon Alpha 2	Protein Coding	4.68	DISEASES inferred ¹⁵
4	NF1	Neurofibromin 1	Protein Coding	4.12	DISEASES inferred ¹⁵

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Variations for Mechanical Ectropion

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Expression for Mechanical Ectropion

Search GEO for disease gene expression data for Mechanical Ectropion.

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Pathways for Mechanical Ectropion

Pathways related to Mechanical Ectropion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.02	IFNA2 CD34
2	Dendritic Cells Developmental Lineage Pathway ⁶⁴	10.49	IFNA2 CD34

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GO Terms for Mechanical Ectropion

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Sources for Mechanical Ectropion

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