MCID: MCK029
MIFTS: 38

Meckel Diverticulum

Categories: Gastrointestinal diseases

Aliases & Classifications for Meckel Diverticulum

MalaCards integrated aliases for Meckel Diverticulum:

Name: Meckel Diverticulum 57 12 29 44 70 32
Meckel's Diverticulum 12 15 17
Persistent Vitelline Duct 12

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
meckel diverticulum:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:9487
OMIM® 57 155140
ICD9CM 34 751.0
MeSH 44 D008467
NCIt 50 C12264
SNOMED-CT 67 37373007
ICD10 32 Q43.0
MedGen 41 C0025037
SNOMED-CT via HPO 68 127962001 263681008
UMLS 70 C0025037

Summaries for Meckel Diverticulum

Disease Ontology : 12 A physical disorder that is characterized by a congenital abnormality characterized by the outpouching or sac formation in the ileum.

MalaCards based summary : Meckel Diverticulum, also known as meckel's diverticulum, is related to intussusception and diverticulitis. An important gene associated with Meckel Diverticulum is BLOC1S1 (Biogenesis Of Lysosomal Organelles Complex 1 Subunit 1). Affiliated tissues include small intestine, pancreas and bone, and related phenotypes are meckel diverticulum and Reduced mammosphere formation

More information from OMIM: 155140

Related Diseases for Meckel Diverticulum

Diseases related to Meckel Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 622)
# Related Disease Score Top Affiliating Genes
1 intussusception 31.0 KIT CRP CD34 ALB
2 diverticulitis 31.0 CRP ATP4A ALB
3 peptic ulcer perforation 30.9 CRP ATP4A ALB
4 small intestine leiomyosarcoma 30.8 KIT CD34
5 blind loop syndrome 30.4 ATP4A ALB
6 intestinal tuberculosis 30.3 CRP ALB
7 emphysematous cholecystitis 30.3 CRP ATP4A
8 duodenal obstruction 30.2 CRP ATP4A ALB
9 carcinoid syndrome 30.2 SYP SST CHGA
10 gastritis 30.2 SST CHGA CDX2 ATP4A
11 hernia, hiatus 30.1 CRP ATP4A
12 signet ring cell adenocarcinoma 30.1 KRT7 CHGA CDX2
13 spindle cell sarcoma 30.0 KRT7 KIT CD34
14 pleural empyema 30.0 CRP ALB
15 hemangiopericytoma, malignant 30.0 SYP KIT CD34
16 interstitial nephritis 30.0 CRP ATP4A ALB
17 muscle cancer 30.0 SYP KIT CD34
18 neurofibroma 30.0 SYP KIT CD34
19 gastrointestinal stromal tumor 29.9 SYP SST KIT CHGA CD34
20 cystitis 29.9 KRT7 KIT CRP
21 volvulus of midgut 29.9 SST GCG CRP ATP4A ALB
22 villous adenoma 29.8 SST KRT7 CDX2
23 colorectal adenocarcinoma 29.8 KRT7 KIT CDX2
24 active peptic ulcer disease 29.8 SST KIT CRP ATP4A ALB
25 celiac disease 1 29.7 GCG CRP ATP4A ALB
26 hydronephrosis 29.7 KRT7 CRP ALB
27 barrett esophagus 29.7 KRT7 CDX2 ATP4A
28 intestinal obstruction 29.6 KRT7 KIT CRP CDX2 CD34 ATP4A
29 mature teratoma 29.6 SYP KRT7 KIT
30 deficiency anemia 29.5 KIT CRP CD34 ATP4A ALB
31 cystic teratoma 29.4 SYP KRT7 KIT CDX2
32 horseshoe kidney 29.4 SYP KRT7 CHGA CDX2
33 intestinal perforation 29.4 KRT7 CRP ATP4A ALB
34 hemangioma 29.4 SYP KRT7 KIT CHGA CD34
35 benign teratoma 29.3 SYP KRT7 CHGA CDX2
36 neuroendocrine tumor 29.3 SYP SST GCG CHGA CDX2 ATP4A
37 adenoma 29.1 SYP SST KRT7 CHGA CDX2
38 constipation 29.1 SST KIT GCG CRP CHGA ATP4A
39 teratoma 28.6 SYP SST KRT7 KIT GCG CHGA
40 meckel's diverticulum cancer 11.2
41 leiomyoma 10.6
42 appendicitis 10.5
43 umbilical hernia 10.4
44 spinal cord sarcoma 10.4 KIT CD34
45 omphalocele 10.4
46 gallbladder leiomyoma 10.4 KIT CD34
47 liver inflammatory pseudotumor 10.4 CRP CD34
48 angiomyoma 10.4 KIT CD34
49 gastric liposarcoma 10.4 KIT CD34
50 mucocele of appendix 10.4 KIT CD34

Graphical network of the top 20 diseases related to Meckel Diverticulum:



Diseases related to Meckel Diverticulum

Symptoms & Phenotypes for Meckel Diverticulum

Human phenotypes related to Meckel Diverticulum:

31
# Description HPO Frequency HPO Source Accession
1 meckel diverticulum 31 HP:0002245

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
G I:
meckel diverticulum
heterotopic gastric mucosa

Clinical features from OMIM®:

155140 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Meckel Diverticulum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.43 ALB ATP4A CD34 CHGA CLDN1 KRT7
2 Upregulation of Wnt pathway GR00057-A-1 8.8 ATP4A CD34 CDX2

MGI Mouse Phenotypes related to Meckel Diverticulum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 ALB ATP4A BLOC1S1 CD34 CDX2 CHGA

Drugs & Therapeutics for Meckel Diverticulum

Search Clinical Trials , NIH Clinical Center for Meckel Diverticulum

Cochrane evidence based reviews: meckel diverticulum

Genetic Tests for Meckel Diverticulum

Genetic tests related to Meckel Diverticulum:

# Genetic test Affiliating Genes
1 Meckel Diverticulum 29

Anatomical Context for Meckel Diverticulum

MalaCards organs/tissues related to Meckel Diverticulum:

40
Small Intestine, Pancreas, Bone, Appendix, Colon, Liver, Kidney

Publications for Meckel Diverticulum

Articles related to Meckel Diverticulum:

(show top 50) (show all 3681)
# Title Authors PMID Year
1
[3 cases of Meckel's diverticulum in the same family]. 57 61
2531871 1989
2
A case report of inverted Meckel's diverticulum. 61
33732404 2021
3
Extra-appendicular neuroendocrine tumors: A report from the TREP project (2000-2020). 61
33522705 2021
4
A Rare and Severe Presentation of Henoch-Schönlein Purpura in an Adolescent With Crescentic Glomerulonephritis, Arrhythmia, Acute Gastrointestinal Bleed, and Neurological Complications. 61
33796429 2021
5
Subacute Meckel's diverticulum perforation. 61
33782062 2021
6
Placental Invasion into the Small Bowel Intestine Through a Myomectomy Scar: A Case Report With Literature Review. 61
33782340 2021
7
A Tale of Two Meckel's: small bowel obstruction secondary to Meckel's Diverticulum. 61
33758652 2021
8
Meckel's diverticulum in adults: seldom suspected and frequently found. 61
33443055 2021
9
Reduced port laparoscopic surgery using umbilical zigzag incision for Meckel's diverticulitis. 61
33422848 2021
10
Perforated mesenteric Meckel's diverticulum: Case report. 61
33486309 2021
11
Rare case of a patient with symptomatic Meckel's diverticulum enteroliths. 61
33608344 2021
12
Intermittent subacute obstruction of small bowel by Giant Meckel's Diverticulum- a case report. 61
33354271 2021
13
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL) Within a Meckel's Diverticulum. 61
32830541 2021
14
Meckel's Diverticulum Bleeding Missed by the First but Detected by the Second Capsule Endoscopy. 61
33678788 2021
15
Meckel's diverticulum - a congenital defect of the gastrointestinal tract underestimated in differential diagnostics. own experience. 61
33751869 2021
16
Perforation of the Meckel's Diverticulum Following Blunt Trauma to the Abdomen. 61
33633897 2021
17
Is the Meckel diverticulum still a bad boy in general surgery? Case report of an intestinal obstruction managed through a single-port access and review of the literature. 61
33532050 2021
18
The Clinical Manifestation Variety and Management Choice of Meckel's Diverticulum with Complication: A Single Center Experience. 61
33628226 2021
19
Perforated Meckel's Diverticulitis in a Patient with Unknown Intestinal Malrotation: Clinical Pitfall. 61
33747593 2021
20
Multidetector computed tomography diagnosis of small bowel intussusceptions in adults: observations in a 10-year single-center study. 61
33269941 2020
21
Intussusception as a rare clinical presentation of a child with type 1 diabetes and diabetic ketoacidosis. 61
33298484 2020
22
Meckel's Diverticulum Causing an Interloop Adhesion and Bowel Obstruction from an Internal Hernia. 61
33342298 2020
23
Gangrenous mesenteric Meckel's diverticulum: an uncommon cause of intestinal obstruction. 61
33295060 2020
24
Meckel's diverticulum and indications for resection. 61
33363991 2020
25
Perforated Meckel's diverticulum from foreign body presenting with pain in the right iliac fossa. 61
33300262 2020
26
Intragastric balloon inside a Meckel's diverticulum: a rare cause of small bowel obstruction. 61
32437036 2020
27
Clinical diagnostic predictive score for Meckel diverticulum. 61
33422327 2020
28
[A Case of Adenocarcinoma Arising from Ectopic Gastric Mucosa in Meckel's Diverticulum with Abdominal Wall Abscess]. 61
33468951 2020
29
Complicated Meckel's Diverticulum in Children: Clinical Presentation, Diagnostic Work-Out, Surgical Approach and Postoperative Complications. 61
33520549 2020
30
Meckel's: A National Surgical Quality Improvement Program Survey in Adults Comparing Diverticulectomy and Small Bowel Resection. 61
33284028 2020
31
Ultrasound findings for spontaneous regression of omphalomesenteric remnant after birth. 61
33289095 2020
32
Meckel's diverticulum perforation in a newborn positive to Sars-Cov-2. 61
32904556 2020
33
Gastrointestinal: Meckel's diverticulum and capsule endoscopy: A bad combination. 61
33190336 2020
34
Detection of a Meckel's diverticulum on PSMA PET/CT: A case report. 61
33102009 2020
35
Clinical management and recommendations for children with more than four episodes of recurrent intussusception following successful reduction of each: an institutional review. 61
32896426 2020
36
Intussusception caused by a small intestinal lipoma with ectopic gastric mucosa containing gastric cystica profunda component cells within the inverted Meckel's diverticulum: a case report. 61
33184680 2020
37
Case report of an intussusception presenting after a trauma jejunorrhaphy. 61
32874568 2020
38
Inverted Meckel's diverticulum: a rare cause of adult intussusception. 61
33074575 2020
39
Single-Instrument Thoracic and Abdominal Surgery in Children: Minimizing Minimally Invasive Surgery. 61
32706622 2020
40
Spontaneous Perforation Of Meckel's Diverticulum Presenting With Generalized Peritonitis. 61
33225665 2020
41
An atypical presentation of a mesenteric Meckel's diverticulum in a 7-year-old warmblood mare: case report. 61
33121487 2020
42
Meckel's Diverticulum Masquerading as Crohn Disease. 61
32692353 2020
43
Gastrointestinal stromal tumor in perforated Meckel's diverticulum: a case report and literature review. 61
33026577 2020
44
Omphalomesenteric duct resection using an intraumbilical round incision or a transumbilical vertical incision: report of two cases. 61
33149889 2020
45
Clinical outcomes of minimally invasive surgery for Meckel diverticulum: a multicenter study. 61
33029480 2020
46
Managing Meckel diverticulum: To resect or not resect? 61
32976232 2020
47
Incarceration of a Meckel's diverticulum by jejunal diverticulosis: an atypical cause of small bowel obstruction. 61
32558107 2020
48
Rare case of Meckel's diverticulum neuroendocrine tumour. 61
32862502 2020
49
[Alveolar capillary dysplasia with misalignment of the pulmonary veins: a case report and literature review]. 61
32987465 2020
50
Clinical features of capsule endoscopy in 825 children: A single-center, retrospective cohort study. 61
33120825 2020

Variations for Meckel Diverticulum

Expression for Meckel Diverticulum

Search GEO for disease gene expression data for Meckel Diverticulum.

Pathways for Meckel Diverticulum

GO Terms for Meckel Diverticulum

Cellular components related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 SST KIT GCG CRP CHGA BLOC1S1

Biological processes related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell degranulation GO:0043303 9.26 KIT CHGA
2 negative regulation of programmed cell death GO:0043069 9.16 KIT ALB
3 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
4 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Sources for Meckel Diverticulum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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