MCID: MCK029
MIFTS: 38

Meckel Diverticulum

Categories: Gastrointestinal diseases

Aliases & Classifications for Meckel Diverticulum

MalaCards integrated aliases for Meckel Diverticulum:

Name: Meckel Diverticulum 57 12 29 44 73
Meckel's Diverticulum 12 15
Persistent Vitelline Duct 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
meckel diverticulum:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 155140
Disease Ontology 12 DOID:9487
ICD10 33 Q43.0
ICD9CM 35 751.0
MeSH 44 D008467
NCIt 50 C12264
SNOMED-CT 68 37373007
MedGen 42 C0025037
SNOMED-CT via HPO 69 263681008 127962001
UMLS 73 C0025037

Summaries for Meckel Diverticulum

MalaCards based summary : Meckel Diverticulum, also known as meckel's diverticulum, is related to meckel's diverticulum cancer and intussusception. An important gene associated with Meckel Diverticulum is FOXA2 (Forkhead Box A2), and among its related pathways/superpathways is Cardiac Progenitor Differentiation. Affiliated tissues include small intestine, pancreas and kidney, and related phenotypes are meckel diverticulum and digestive/alimentary

Wikipedia : 76 A Meckel''s diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine... more...

Description from OMIM: 155140

Related Diseases for Meckel Diverticulum

Diseases related to Meckel Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 meckel's diverticulum cancer 11.7
2 intussusception 10.4
3 small intestine leiomyosarcoma 10.4
4 omphalomesenteric cyst 10.4
5 squamous cell carcinoma of the small intestine 10.4
6 ehlers-danlos syndrome 10.1
7 gastrointestinal stromal tumor 10.1
8 barrett esophagus 10.1
9 lymphoma 10.1
10 neuroendocrine tumor 10.1
11 appendicitis 10.1
12 leukemia, acute lymphoblastic 9.9
13 crohn's disease 9.9
14 marginal zone b-cell lymphoma 9.9
15 crohn's colitis 9.9
16 mucositis 9.9
17 lymphocytic leukemia 9.9
18 patau syndrome 9.9
19 gastroenteritis 9.9
20 adenomyoma 9.9
21 cystic teratoma 9.9
22 adenocarcinoma 9.9
23 rhabdomyosarcoma 9.9
24 teratoma 9.9
25 adenoma 9.9
26 diverticulitis 9.9
27 intestinal obstruction 9.9
28 desmoplastic small round cell tumor 9.9
29 horseshoe kidney 9.9

Graphical network of the top 20 diseases related to Meckel Diverticulum:



Diseases related to Meckel Diverticulum

Symptoms & Phenotypes for Meckel Diverticulum

Symptoms via clinical synopsis from OMIM:

57
G I:
meckel diverticulum
heterotopic gastric mucosa


Clinical features from OMIM:

155140

Human phenotypes related to Meckel Diverticulum:

32
# Description HPO Frequency HPO Source Accession
1 meckel diverticulum 32 HP:0002245

MGI Mouse Phenotypes related to Meckel Diverticulum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 FOXA2 FOXM1 HRH2 KIT
2 liver/biliary system MP:0005370 9.55 ACOT7 FOXA2 FOXM1 KIT SERPINE1
3 neoplasm MP:0002006 9.26 FOXA2 FOXM1 KIT SERPINE1
4 respiratory system MP:0005388 8.92 FOXA2 FOXM1 KIT SERPINE1

Drugs & Therapeutics for Meckel Diverticulum

Search Clinical Trials , NIH Clinical Center for Meckel Diverticulum

Cochrane evidence based reviews: meckel diverticulum

Genetic Tests for Meckel Diverticulum

Genetic tests related to Meckel Diverticulum:

# Genetic test Affiliating Genes
1 Meckel Diverticulum 29

Anatomical Context for Meckel Diverticulum

MalaCards organs/tissues related to Meckel Diverticulum:

41
Small Intestine, Pancreas, Kidney, Liver, Colon, Testes, Bone

Publications for Meckel Diverticulum

Articles related to Meckel Diverticulum:

(show top 50) (show all 508)
# Title Authors Year
1
Meckel Diverticulum ( 29763135 )
2018
2
Diagnosis of Meckel diverticulum on endoscopic retrograde ileography in a child. ( 29600598 )
2018
3
Retained Capsule Endoscopy in a Patient with a Meckel Diverticulum Previously Treated by Endovascular Embolization. ( 29642985 )
2018
4
Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum. ( 29515402 )
2018
5
Simple diverticulectomy is adequate for management of bleeding Meckel diverticulum. ( 29460177 )
2018
6
Retained Capsule Endoscopy in a Patient with a Meckel Diverticulum Previously Treated by Endovascular Embolization. ( 29428023 )
2018
7
Adenocarcinoma in a Meckel's diverticulum presenting as a phlegmon: a case report and a review of the literature. ( 30353991 )
2018
8
Mesenteric location of a perforated Meckel's diverticulum in an elderly patient with acute appendicitis: a case report. ( 29687560 )
2018
9
Meckel's Diverticulum in Crohn's Disease Revisited: A Case of Meckel's Diverticulitis in a Patient with Stricturing Crohn's Disease. ( 30148017 )
2018
10
The Coexistence of a Horseshoe Kidney and Meckel Diverticulum With Dramatic Mobility Revealed Through 99mTc Pertechnetate Imaging. ( 30179918 )
2018
11
Hemorrhage and intestinal obstruction secondary to a Meckel's diverticulum: a case report. ( 29168644 )
2018
12
Perforated Meckel Diverticulum: A Rare Cause of Acute Abdomen in Children. ( 29324630 )
2018
13
A rare complication in a liver transplant patient: Meckel diverticulum perforation due to biliary stent. ( 30368122 )
2018
14
Retained Capsule Endoscopy in a Patient with a Meckel Diverticulum Previously Treated by Endovascular Embolization. ( 30454294 )
2018
15
Bleeding Meckel Diverticulum: A Retrospective Analysis of Computed Tomography Enterography Findings. ( 30531229 )
2018
16
THE ROLE OF CAPSULE ENDOSCOPY IN URGENT EVALUATION OF OBSCURE GASTROINTESTINAL BLEEDING: A CASE SERIES OF MECKEL DIVERTICULUM . ( 30539984 )
2018
17
Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child. ( 30042102 )
2018
18
Pelvic tumor fed by the superior mesenteric artery. What is your diagnosis? GIST complicating Meckel's diverticulum. ( 29396111 )
2018
19
A newborn patient with both annular pancreas and Meckel's diverticulum: A case report of an unusual association. ( 29703052 )
2018
20
TeleNEN as a telemedicine model for neuroendocrine neoplasm management in case of Meckel's diverticulum NET. ( 29952421 )
2018
21
Ileal knotting secondary to a mesodiverticular band associated with axial torsion of a Meckel's diverticulum and small bowel volvulus. ( 29875596 )
2018
22
Neuroendocrine tumours within a Meckel's diverticulum. ( 29046099 )
2018
23
Capsule endoscopic appearance of a Meckel's diverticulum in an adult. ( 29307149 )
2018
24
Multifaceted behavior of Meckel's diverticulum in children. ( 29331260 )
2018
25
Inverted Meckel's diverticulum in an adult patient diagnosed via capsule endoscopy. ( 29368940 )
2018
26
Meckel's diverticulum in the adult: Prophylactic surgery. ( 29397337 )
2018
27
Diagnosis of Meckel's Diverticulum Using Colon Capsule Endoscopy for Small Bowel Investigation. ( 29482315 )
2018
28
Perforation of Meckel's diverticulum by a foreign body. ( 29627186 )
2018
29
Food ileus secondary to citrus fruit associated with a Meckel's diverticulum: a case report and review of the literature. ( 29644034 )
2018
30
Outcomes of laparoscopic resection of Meckel's diverticulum are equivalent to open laparotomy. ( 29661575 )
2018
31
Atypical Presentation of Meckel's Diverticulum in a Hispanic Man: A Case Report. ( 29686835 )
2018
32
Elongated Appearance of Meckel's Diverticulum on 99mTcO4 Scintigraphy. ( 29742596 )
2018
33
Meckel's Diverticulum in Children-Parameters Predicting the Presence of Gastric Heterotopia. ( 29750325 )
2018
34
Unique presentation of a ruptured Meckel's diverticulum after blunt trauma. ( 29769192 )
2018
35
Heterotopic pancreas without Meckel's diverticulum in children as unique cause of gastrointestinal bleeding: think about it! ( 29785678 )
2018
36
Giant Meckel's Diverticulum. ( 29845568 )
2018
37
Meckel's diverticulum-associated small bowel obstruction after appendectomy. ( 29878634 )
2018
38
Meckel's diverticulum on third-generation video capsule endoscopy: intradiverticular ulcer, ectopic gastric mucosa, and active bleeding. ( 29895061 )
2018
39
Laparoscopic treatment of a vesicointestinal fistula due to a Meckel's diverticulum: a case report and review of the literature. ( 29915984 )
2018
40
Perforation of a mesenteric Meckel's diverticulum. ( 29977514 )
2018
41
Meckel's diverticulum: clinical features, diagnosis and management. ( 30032625 )
2018
42
Malignancy and Meckel's diverticulum: A systematic literature review and 14-year experience at a tertiary referral center. ( 30083336 )
2018
43
Combined Gastric and Pancreatic Tissue Inside a Meckel's Diverticulum. ( 30109801 )
2018
44
Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century. ( 30170459 )
2018
45
Double-Balloon Enteroscopy-Assisted Diagnosis of Malignancy Arising From Meckel's Diverticulum. ( 30201596 )
2018
46
Significant bleeding from Meckel's diverticulum after blunt abdominal trauma: a case report. ( 30227894 )
2018
47
Meckel's Diverticulum in Adults: Surgical Concerns. ( 30234126 )
2018
48
Complicated Meckel's diverticulum: Presentation modes in adults. ( 30235734 )
2018
49
Meckel's diverticulum in the adult: surgical treatment. ( 30259784 )
2018
50
Inverted Meckel's diverticulum: Two case reports and a review of the literature. ( 30283607 )
2018

Variations for Meckel Diverticulum

Expression for Meckel Diverticulum

Search GEO for disease gene expression data for Meckel Diverticulum.

Pathways for Meckel Diverticulum

Pathways related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.35 FOXA2 KIT

GO Terms for Meckel Diverticulum

Biological processes related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 8.96 HRH2 KIT
2 digestive tract development GO:0048565 8.62 HRH2 KIT

Molecular functions related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 KIT SERPINE1

Sources for Meckel Diverticulum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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