MCID: MCK029
MIFTS: 33

Meckel Diverticulum

Categories: Gastrointestinal diseases

Aliases & Classifications for Meckel Diverticulum

MalaCards integrated aliases for Meckel Diverticulum:

Name: Meckel Diverticulum 57 12 29 44 73
Meckel's Diverticulum 12 15
Persistent Vitelline Duct 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
meckel diverticulum:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 155140
Disease Ontology 12 DOID:9487
ICD10 33 Q43.0
ICD9CM 35 751.0
MeSH 44 D008467
NCIt 50 C12264
MedGen 42 C0025037
SNOMED-CT via HPO 69 263681008
UMLS 73 C0025037

Summaries for Meckel Diverticulum

MalaCards based summary : Meckel Diverticulum, also known as meckel's diverticulum, is related to meckel's diverticulum cancer and small intestine leiomyosarcoma. An important gene associated with Meckel Diverticulum is FOXA2 (Forkhead Box A2), and among its related pathways/superpathways is Cardiac Progenitor Differentiation. Affiliated tissues include small intestine, and related phenotypes are meckel diverticulum and behavior/neurological

Wikipedia : 76 A Meckel\'s diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine... more...

Description from OMIM: 155140

Related Diseases for Meckel Diverticulum

Diseases related to Meckel Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 meckel's diverticulum cancer 11.5
2 small intestine leiomyosarcoma 10.2
3 omphalomesenteric cyst 10.2
4 squamous cell carcinoma of the small intestine 10.2
5 intussusception 10.2
6 ehlers-danlos syndrome 10.0
7 gastrointestinal stromal tumor 10.0
8 neuroendocrine tumor 10.0
9 lymphoma 9.8
10 gastroenteritis 9.8
11 cystic teratoma 9.8
12 adenocarcinoma 9.8
13 rhabdomyosarcoma 9.8
14 teratoma 9.8
15 adrenal gland hyperfunction 9.8
16 pancreatitis 9.8
17 appendicitis 9.8
18 intestinal obstruction 9.8
19 desmoplastic small round cell tumor 9.8

Graphical network of the top 20 diseases related to Meckel Diverticulum:



Diseases related to Meckel Diverticulum

Symptoms & Phenotypes for Meckel Diverticulum

Symptoms via clinical synopsis from OMIM:

57
GI:
meckel diverticulum
heterotopic gastric mucosa


Clinical features from OMIM:

155140

Human phenotypes related to Meckel Diverticulum:

32
# Description HPO Frequency HPO Source Accession
1 meckel diverticulum 32 HP:0002245

MGI Mouse Phenotypes related to Meckel Diverticulum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.88 ACOT7 CLMP FOXA2 HRH2 KIT TRAK1
2 homeostasis/metabolism MP:0005376 9.8 ACOT7 CLMP FOXA2 FOXM1 HRH2 KIT
3 cardiovascular system MP:0005385 9.77 CLMP FOXA2 FOXM1 KIT SERPINE1
4 digestive/alimentary MP:0005381 9.62 FOXA2 FOXM1 HRH2 KIT
5 liver/biliary system MP:0005370 9.55 ACOT7 FOXA2 FOXM1 KIT SERPINE1
6 neoplasm MP:0002006 9.26 FOXA2 FOXM1 KIT SERPINE1
7 respiratory system MP:0005388 8.92 FOXA2 FOXM1 KIT SERPINE1

Drugs & Therapeutics for Meckel Diverticulum

Search Clinical Trials , NIH Clinical Center for Meckel Diverticulum

Cochrane evidence based reviews: meckel diverticulum

Genetic Tests for Meckel Diverticulum

Genetic tests related to Meckel Diverticulum:

# Genetic test Affiliating Genes
1 Meckel Diverticulum 29

Anatomical Context for Meckel Diverticulum

MalaCards organs/tissues related to Meckel Diverticulum:

41
Small Intestine

Publications for Meckel Diverticulum

Articles related to Meckel Diverticulum:

(show all 36)
# Title Authors Year
1
Meckel Diverticulum ( 29763135 )
2018
2
Diagnosis of Meckel diverticulum on endoscopic retrograde ileography in a child. ( 29600598 )
2018
3
Retained Capsule Endoscopy in a Patient with a Meckel Diverticulum Previously Treated by Endovascular Embolization. ( 29642985 )
2018
4
Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum. ( 29515402 )
2018
5
Simple diverticulectomy is adequate for management of bleeding Meckel diverticulum. ( 29460177 )
2018
6
Retained Capsule Endoscopy in a Patient with a Meckel Diverticulum Previously Treated by Endovascular Embolization. ( 29428023 )
2018
7
Perforated Meckel Diverticulum: A Rare Cause of Acute Abdomen in Children. ( 29324630 )
2018
8
Acute Painless Lower Gastrointestinal Bleed That Mimics Meckel Diverticulum. ( 28328694 )
2017
9
Optimizing surgical resection of the bleeding Meckel diverticulum in children. ( 28359587 )
2017
10
Wandering Pelvic Mass: Rhabdomyosarcoma of the Meckel Diverticulum. ( 28284478 )
2017
11
A Pediatric Case of Meckel Diverticulum with Uncommon Presentation Showing no Lower Gastrointestinal Bleeding. ( 28435651 )
2017
12
Reminiscing on Remnants: Imaging of Meckel Diverticulum and Its Complications in Adults. ( 28834452 )
2017
13
Spontaneous perforation of Meckel diverticulum: A case report. ( 29384952 )
2017
14
Large Enterolith Complicating a Meckel Diverticulum Causing Obstructive Ileus in an Adolescent Male Patient. ( 29391964 )
2017
15
Meckel Diverticulum Harboring a Rare Gastrointestinal Stromal Tumor. ( 28331460 )
2017
16
Laparoscopic treatment of hemorrhagic Meckel diverticulum after diagnosis with wireless capsule endoscopy and double-balloon enteroscopy. ( 28229609 )
2017
17
Prenatal imaging presentation of Meckel diverticulum. ( 28412231 )
2017
18
Clinical characteristics of Meckel diverticulum in children: A retrospective review of a 15-year single-center experience. ( 28796070 )
2017
19
Unusual presentation of obscure Meckel diverticulum treated with robot-assisted diverticulectomy: A case report. ( 27741148 )
2016
20
Complicated Meckel diverticulum in a 15-year-old boy. ( 27787281 )
2016
21
Inverted Meckel diverticulum as a lead point of small bowel intussusception: misinterpreting case as a lipoma. ( 27179156 )
2016
22
Meckel diverticulum in exomphalos minor. ( 27478815 )
2016
23
Incidental Finding of a Neuroendocrine Tumor Arising from Meckel Diverticulum During Hernia Repair - A Case Report and Literature Review. ( 27069171 )
2016
24
Torsed Meckel Diverticulum Mimicking a Cystic Teratoma. ( 27380610 )
2016
25
Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: case report. ( 26610855 )
2015
26
A common case of gastroenteritis in a child followed by an axial torsion of Meckel diverticulum: a rare and unusual complication. ( 23436900 )
2013
27
Intussusception secondary to a meckel diverticulum in an adolescent. ( 23547727 )
2013
28
Diagnosis and management of pediatric appendicitis, intussusception, and Meckel diverticulum. ( 22595706 )
2012
29
An unusual cause of intestinal obstruction in an infant: phytobezoar within a Meckel diverticulum. ( 21843742 )
2011
30
Adult intussusception caused by an inverted meckel diverticulum. ( 21712947 )
2011
31
A gastrointestinal stromal tumor in Meckel diverticulum in an 86-year-old patient. ( 20562591 )
2010
32
Presumed appendiceal abscess discovered to be ruptured Meckel diverticulum following percutaneous drainage. ( 18491085 )
2008
33
Desmoplastic small round cell tumor of Meckels diverticulum. ( 17664485 )
2007
34
Small bowel obstruction secondary to Meckel diverticulum detected and treated laparoscopically--case report. ( 17057578 )
2006
35
Sonographic appearances of inverted Meckel diverticulum with intussusception. ( 9094232 )
1997
36
Primary lymphoma of Meckel diverticulum: a case report. ( 3968885 )
1985

Variations for Meckel Diverticulum

Expression for Meckel Diverticulum

Search GEO for disease gene expression data for Meckel Diverticulum.

Pathways for Meckel Diverticulum

Pathways related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.35 FOXA2 KIT

GO Terms for Meckel Diverticulum

Biological processes related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.46 FOXA2 FOXM1 KIT TRAK1
2 visual learning GO:0008542 8.96 HRH2 KIT
3 digestive tract development GO:0048565 8.8 CLMP HRH2 KIT

Molecular functions related to Meckel Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 KIT SERPINE1

Sources for Meckel Diverticulum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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