MAS
MCID: MCN007
MIFTS: 53

Meconium Aspiration Syndrome (MAS)

Categories: Fetal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Meconium Aspiration Syndrome

MalaCards integrated aliases for Meconium Aspiration Syndrome:

Name: Meconium Aspiration Syndrome 12 20 58 54 44 15 17 70
Neonatal Aspiration of Meconium 12 32
Meconium Aspiration 12
Mas 20

Characteristics:

Orphanet epidemiological data:

58
meconium aspiration syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:11049
MeSH 44 D008471
NCIt 50 C87093
SNOMED-CT 67 85779008
ICD10 32 P24.0 P24.01
MESH via Orphanet 45 D008471
ICD10 via Orphanet 33 P24.0
UMLS via Orphanet 71 C0025048
Orphanet 58 ORPHA70588
UMLS 70 C0025048

Summaries for Meconium Aspiration Syndrome

GARD : 20 Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. This can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. Treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep suctioning of the windpipe, antibiotics to treat infection, oxygen to keep blood levels normal, and radiant heat to maintain body temperature. In severe cases, the baby may need assistance breathing (ventilator).

MalaCards based summary : Meconium Aspiration Syndrome, also known as neonatal aspiration of meconium, is related to surfactant dysfunction and bronchopneumonia, and has symptoms including dyspnea, apnea and cheyne-stokes respiration. An important gene associated with Meconium Aspiration Syndrome is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Sodium citrate and Poractant alfa have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and neutrophil, and related phenotypes are fetal distress and respiratory distress

Disease Ontology : 12 A lung disease that is characterized by a newborn breathing in a mixture of meconium and amniotic fluid into the lungs around the time of delivery.

Wikipedia : 73 Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition... more...

Related Diseases for Meconium Aspiration Syndrome

Diseases related to Meconium Aspiration Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 506)
# Related Disease Score Top Affiliating Genes
1 surfactant dysfunction 30.9 SFTPB ABCA3
2 bronchopneumonia 30.6 TNF IL6 CXCL8
3 neonatal respiratory failure 30.5 SFTPB SCGB1A1 ABCA3
4 bronchopulmonary dysplasia 30.5 SFTPB SCGB1A1 CXCL8
5 funisitis 30.4 TNF OXT IL6 CXCL8
6 toxic pneumonitis 30.4 SFTPB SCGB1A1
7 streptococcus pneumonia 30.4 TNF IL6 CXCL8
8 pulmonary interstitial emphysema 30.3 SFTPB ABCA3
9 pulmonary hypertension 30.3 TNF PDE5A IL6 EDN1 CXCL8 CPS1
10 aspiration pneumonitis 30.3 TNF OXT CXCL8
11 otitis media 30.2 TNF IL6 IFNG CXCL8
12 chorioamnionitis 30.2 TNF OXT IL6 CXCL8 CSF2
13 respiratory distress syndrome in premature infants 30.1 SFTPB ABCA3
14 proteasome-associated autoinflammatory syndrome 1 30.1 TNF IL6 IFNG CXCL8
15 rubella 30.1 TNF IL6 IFNG
16 cerebral palsy 30.1 TNF IL6 CXCL8 CSF3
17 placenta disease 30.1 TNF OXT IL6 CXCL8
18 newborn respiratory distress syndrome 30.0 SFTPB SCGB1A1 ABCA3
19 endocarditis 29.9 TNF IL6 IFNG CXCL8 CCL4
20 respiratory failure 29.9 TNF SFTPB SCGB1A1 IL6 EDN1 CXCL8
21 bronchiolitis 29.6 TNF IL6 IFNG CXCL8 CSF2 CCL4
22 bacterial pneumonia 29.6 TNF SFTPB SCGB1A1 IL6 CXCL8 CSF3
23 pneumonia 29.4 TNF SFTPB SCGB1A1 IL6 IFNG CXCL8
24 pulmonary edema 29.4 TNF SCGB1A1 OXT EDN1 CXCL8 CSF3
25 vascular disease 29.2 TNF IL6 IFNG EDN1 CSF3 ACE2
26 adult respiratory distress syndrome 29.2 TNF SFTPB SCGB1A1 IL6 CXCL8 CSF3
27 thrombocytopenia 29.2 TNF IL6 IFNG EDN1 CXCL8 CSF3
28 persistent fetal circulation syndrome 29.2 TNF PDE5A OXT IL6 EDN1
29 lung disease 28.9 TNF SFTPB SCGB1A1 IL6 IFNG EDN1
30 pulmonary hypertension, neonatal 11.2
31 pneumothorax 10.6
32 external pathological resorption 10.4 TNF IL6
33 scorpion envenomation 10.4 TNF IL6
34 physiological polycythemia 10.4 TNF IL6
35 acute transverse myelitis 10.4 IL6 CXCL8
36 acute gonococcal cervicitis 10.4 IL6 CXCL8
37 toxicodendron dermatitis 10.4 TNF CXCL8
38 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
39 cardiogenic shock 10.4 TNF IL6
40 haemophilus influenzae 10.3 TNF CXCL8
41 null-cell leukemia 10.3 TNF IL6
42 paraneoplastic syndromes 10.3 IL6 CSF3
43 staphylococcal toxic shock syndrome 10.3 TNF IFNG
44 ulcer of lower limbs 10.3 TNF IL6
45 autoimmune myocarditis 10.3 TNF IFNG
46 ige responsiveness, atopic 10.3
47 palladium allergic contact dermatitis 10.3 TNF CSF2
48 spotted fever rickettsiosis 10.3 TNF IFNG
49 polyarticular juvenile idiopathic arthritis 10.3 TNF IFNG
50 paraquat lung 10.3 SFTPB SCGB1A1

Graphical network of the top 20 diseases related to Meconium Aspiration Syndrome:



Diseases related to Meconium Aspiration Syndrome

Symptoms & Phenotypes for Meconium Aspiration Syndrome

Human phenotypes related to Meconium Aspiration Syndrome:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fetal distress 58 31 frequent (33%) Frequent (79-30%) HP:0025116
2 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
3 caesarian section 58 31 frequent (33%) Frequent (79-30%) HP:0011410
4 transient pulmonary infiltrates 58 31 frequent (33%) Frequent (79-30%) HP:0005828
5 postterm pregnancy 58 31 frequent (33%) Frequent (79-30%) HP:0031169
6 abnormal heart rate variability 58 31 frequent (33%) Frequent (79-30%) HP:0031860
7 intrauterine growth retardation 58 31 occasional (7.5%) Occasional (29-5%) HP:0001511
8 atelectasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100750
9 pulmonary arterial hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002092
10 maternal diabetes 58 31 occasional (7.5%) Occasional (29-5%) HP:0009800
11 hypoxemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012418
12 pneumothorax 58 31 occasional (7.5%) Occasional (29-5%) HP:0002107
13 aspiration pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011951
14 neonatal asphyxia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012768
15 maternal hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0008071
16 wheezing 58 31 occasional (7.5%) Occasional (29-5%) HP:0030828
17 premature rupture of membranes 58 31 occasional (7.5%) Occasional (29-5%) HP:0001788
18 meconium stained amniotic fluid 58 31 occasional (7.5%) Occasional (29-5%) HP:0012420
19 pneumomediastinum 58 31 occasional (7.5%) Occasional (29-5%) HP:0025421
20 encephalopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0001298
21 pulmonary insufficiency 58 31 very rare (1%) Very rare (<4-1%) HP:0010444
22 abnormal pulmonary thoracic imaging finding 58 Frequent (79-30%)

UMLS symptoms related to Meconium Aspiration Syndrome:


dyspnea; apnea; cheyne-stokes respiration; coughing; hoarseness

MGI Mouse Phenotypes related to Meconium Aspiration Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ABCA3 ACE2 CPS1 CSF2 EDN1 IFNG
2 renal/urinary system MP:0005367 9.61 ABCA3 ACE2 CSF2 CSF3 EDN1 IFNG
3 respiratory system MP:0005388 9.23 ABCA3 ACE2 CSF2 IFNG IL6 SCGB1A1

Drugs & Therapeutics for Meconium Aspiration Syndrome

Drugs for Meconium Aspiration Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 4 68-04-2
2 Poractant alfa Approved Phase 4 129069-19-8
3
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
4 Respiratory System Agents Phase 4
5 Pulmonary Surfactants Phase 4
6 Pharmaceutical Solutions Phase 4
7 Citrate Phase 4
8 Vasodilator Agents Phase 4
9 Phosphodiesterase Inhibitors Phase 4
10 Phosphodiesterase 5 Inhibitors Phase 4
11 Sildenafil Citrate Phase 4 171599-83-0
12
Nitric Oxide Approved Phase 3 10102-43-9 145068
13 Vasoconstrictor Agents Phase 3
14 Immunoglobulins
15 Antibodies

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Oral Sildenafil in Persistent Pulmonary Hypertension of Neonates Secondary to Meconium Aspiration Syndrome: A Randomized Placebo Controlled Trial Completed NCT01757782 Phase 4 Oral Sildenafil;Placebo (distilled water)
2 Zekai Tahir Burak Maternity Teaching Hospital Completed NCT02041546 Phase 4 Lung lavage with surfactant;Bolus surfactant
3 Surfactant Lavage vs. Bolus Surfactant in Neonates With Meconium Aspiration Unknown status NCT00312507 Phase 3 Bovine Lipid Extract Surfactant (administered by lavage);Bovine Lipid Extract Surfactant (administered by bolus)
4 A Multicenter, Randomized, Controlled Trial Comparing the Safety and Effectiveness of Bronchoalveolar Lavage With Lucinactant to Standard Care for the Treatment of the Meconium Aspriation Syndrome (MAS) in Newborn Infants Terminated NCT00004500 Phase 3 Lucinactant
5 Pilot Study: High Flow Ventilation With Volume Guarantee Unknown status NCT02571231
6 Role of Endotracheal Suction on the Occurrence of Meconium Aspiration Syndrome in Non-vigorous Meconium Stained Neonates- A Randomized Controlled Trial Completed NCT01758822
7 Role of Intrapartum Oropharyngeal (IP-OP) Suction in Neonates Born Through Meconium Stained Amniotic Fluid on Meconium Aspiration Syndrome Completed NCT01328483
8 Surfactant Lung Lavage Versus Standard Care In The Treatment Of Meconium Aspiration Syndrome- A Randomized Controlled Study Completed NCT01310621 Bovine surfactant
9 Time of Initiation of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid: a Cross-over Randomized, Control Trial Completed NCT04076189
10 Use of Heliox in the Management of Neonates With Meconium Aspiration Syndrome Completed NCT01274845
11 Study on the Effect of Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome Parallel Synchronized Intermittent Mandatory Ventilation; Synchronous Maudatory Ventilation Completed NCT02620891
12 Antibody Secreting Cell (ASC) and Immunoactive Protein Profiles in Neonates on Extracorporeal Membrane Oxygenation (ECMO) Completed NCT00371241
13 Pulmonary Function Using Non-invasive Forced Oscillometry Respiratory Testing: A Prospective Observational Study Recruiting NCT03346343
14 Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities: a Randomized Clinical Trial Not yet recruiting NCT03996317
15 Meconium Aspiration Syndrome and Non-vigorous Neonates-Pilot Study Withdrawn NCT02708563

Search NIH Clinical Center for Meconium Aspiration Syndrome

Cochrane evidence based reviews: meconium aspiration syndrome

Genetic Tests for Meconium Aspiration Syndrome

Anatomical Context for Meconium Aspiration Syndrome

MalaCards organs/tissues related to Meconium Aspiration Syndrome:

40
Heart, Lung, Neutrophil, Bone, Thymus, Brain, Smooth Muscle

Publications for Meconium Aspiration Syndrome

Articles related to Meconium Aspiration Syndrome:

(show top 50) (show all 1105)
# Title Authors PMID Year
1
Pancreatic phospholipase A2 contributes to lung injury in experimental meconium aspiration. 54 61
16627874 2006
2
Serum endothelin-1 and transforming growth factor-beta levels in the newborns with respiratory distress. 54 61
17392579 2006
3
Hypoxemia inducing endothelin-1 secretion in meconium aspiration in piglets. 61 54
11811222 2001
4
Study of plasma endothelin-1 concentrations in Taiwanese neonates with respiratory distress. 54 61
11413881 2001
5
Effect of meconium aspiration on plasma endothelin-1 level and pulmonary hemodynamics in a piglet model. 61 54
10473897 1999
6
The prognostic value of the level of lactate in umbilical cord blood in predicting complications of neonates with meconium aspiration syndrome. 61
31340690 2021
7
Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome. 61
33806734 2021
8
Morbidity of conversion from venovenous to venoarterial ECMO in neonates with meconium aspiration or persistent pulmonary hypertension. 61
33645507 2021
9
Surfactant use in late preterm infants: a survey among Belgian neonatologists. 61
32970243 2021
10
Meconium Aspiration Syndrome: A Narrative Review. 61
33802887 2021
11
Maternal and Perinatal Outcomes of Expectant Management of Full-Term, Low-Risk, Nulliparous Patients. 61
33416294 2021
12
Guidelines for surfactant replacement therapy in neonates. 61
33552321 2021
13
Foley catheter vs oral misoprostol for induction of labor: individual participant data meta-analysis. 61
33258514 2021
14
Survival and Developmental Outcomes of Neonates Treated with Extracorporeal Membrane Oxygenation: A 10-Year Single-Center Experience. 61
33058857 2021
15
The use of supplemental hydrocortisone in the management of persistent pulmonary hypertension of the newborn. 61
33589734 2021
16
Neonatal mortality associated with perinatal asphyxia: a population-based study in a middle-income country. 61
33639885 2021
17
Clinical and echocardiography predictors of response to inhaled nitric oxide in hypoxemic term and near-term neonates. 61
33434418 2021
18
Outcomes of endotracheal suctioning in non-vigorous neonates born through meconium-stained amniotic fluid: a systematic review and meta-analysis. 61
32561566 2021
19
Evaluation of Morbidities and Complications of Neonatal ─░ntensive Care Unit Patients with Respiratory Disorders at Different Gestational Ages. 61
33517566 2021
20
The "Hub and Spoke" (HandS) ECMO for "Resuscitating" Neonates with Respiratory Life-Threatening Conditions. 61
33466419 2021
21
Surfactant dysfunction disorder masquerading as meconium aspiration syndrome and persistent pulmonary hypertension of the newborn. 61
33504532 2021
22
Optimal delivery timing for twin pregnancies: A population-based retrospective cohort study. 61
33420725 2021
23
The minimal invasive surfactant therapy: experience from a low resource setting. 61
33491516 2021
24
Perinatal characteristics and delivery room management of infants born through MSAF. 61
33096159 2020
25
Study the effect of increased maternal BMI on foetal outcome: A prospective observational study. 61
33681017 2020
26
Risk factors for mortality among neonates admitted to a special care unit in a low-resource setting. 61
33228644 2020
27
Clinical Characteristics and Outcomes for Neonates, Infants, and Children Referred to a Regional Pediatric Intensive Care Transport Service for Extracorporeal Membrane Oxygenation. 61
32886461 2020
28
Effects of Metabolic Syndrome on Intestinal Flora, Inflammatory Factors, and Infants of Pregnant Patients. 61
33073963 2020
29
Optimal Oxygen Targets in Term Lambs with Meconium Aspiration Syndrome and Pulmonary Hypertension. 61
32609558 2020
30
Bidirectional Ductal Shunting and Preductal to Postductal Oxygenation Gradient in Persistent Pulmonary Hypertension of the Newborn. 61
32942726 2020
31
[A clinical epidemiological investigation of neonatal acute respiratory distress syndrome in southwest Hubei, China]. 61
32933623 2020
32
Management of isolated oligohydramnios in Korea: a questionnaire-based study of clinical practice patterns among the members of the Korean Society of Maternal Fetal Medicine. 61
32689762 2020
33
Clinical profile and outcome of neonatal pneumothorax in resource-limited neonatal intensive care unit. 61
32981419 2020
34
Resuscitation of non-vigorous neonates born through meconium-stained amniotic fluid: post policy change impact analysis. 61
32963086 2020
35
Surfactant Injury in the Early Phase of Severe Meconium Aspiration Syndrome. 61
32348683 2020
36
Association of abnormal first stage of labor duration and maternal and neonatal morbidity. 61
32883453 2020
37
Pathophysiological effects of intravenous phosphodiesterase type 4 inhibitor in addition to surfactant lavage in meconium-injured newborn piglet lungs. 61
32478966 2020
38
Effect of Whole Body Hypothermia on Surfactant Function When Amniotic Fluid Is Meconium Stained. 61
28708464 2020
39
Can neonatal pneumothorax be successfully managed in regional Australia? 61
32777925 2020
40
[Meconium aspiration syndrome: Poor outcome predicting factors]. 61
32800723 2020
41
Risk of adverse pregnancy outcomes of late- and postterm pregnancies in advanced maternal age: A national cohort study. 61
32072610 2020
42
Surfactant lavage for neonatal meconium aspiration syndrome-An updated meta-analysis. 61
32780575 2020
43
Point-of-care lung ultrasound in three neonates with COVID-19. 61
32504135 2020
44
Ten years of the neonatal respiratory extracorporeal membrane oxygenation program in an Argentinian public hospital. 61
32677787 2020
45
An Asian multicenter retrospective study on persistent pulmonary hypertension of the newborn: incidence, etiology, diagnosis, treatment and outcome. 61
30318951 2020
46
Surfactant therapy for meconium aspiration syndrome in neonates: a systematic overview of systematic reviews and recent clinical trials. 61
32394731 2020
47
Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia. 61
32532911 2020
48
The frequency of pulmonary hypertension in newborn with intrauterine growth restriction. 61
32415157 2020
49
Transcervical Foley Balloon Plus Vaginal Misoprostol versus Vaginal Misoprostol Alone for Cervical Ripening in Nulliparous Obese Women: A Multicenter, Randomized, Comparative-Effectiveness Trial. 61
32299108 2020
50
Which way is better to deliver the very heavy baby: mode of delivery, maternal and neonatal outcome. 61
32125523 2020

Variations for Meconium Aspiration Syndrome

Expression for Meconium Aspiration Syndrome

Search GEO for disease gene expression data for Meconium Aspiration Syndrome.

Pathways for Meconium Aspiration Syndrome

Pathways related to Meconium Aspiration Syndrome according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 TNF IL6 IFNG EDN1 CXCL8 CSF3
2
Show member pathways
13.3 TNF IL6 IFNG CXCL8 CSF3 CSF2
3
Show member pathways
13.22 TNF PLA2G10 IL6 CXCL8 CSF3 CSF2
4
Show member pathways
12.87 TNF IL6 CXCL8 CSF2 CCL4
5
Show member pathways
12.45 TNF PLA2G10 IFNG CSF2
6
Show member pathways
12.36 IL6 IFNG CSF3 CSF2
7
Show member pathways
12.29 TNF IL6 CXCL8 CCL4
8
Show member pathways
12.26 TNF IL6 IFNG CXCL8
9
Show member pathways
12.18 TNF IL6 IFNG CXCL8 CSF3 CSF2
10
Show member pathways
12.14 TNF IL6 IFNG CXCL8
11 11.97 TNF IL6 IFNG CXCL8
12 11.94 TNF IL6 IFNG CSF3 CSF2
13 11.93 TNF IL6 EDN1 CSF2
14 11.9 IL6 IFNG EDN1
15 11.88 IL6 IFNG CXCL8
16 11.87 TNF CXCL8 CCL4
17 11.87 TNF IL6 EDN1 CXCL8
18 11.85 TNF IL6 CSF3 CSF2
19 11.84 TNF IL6 IFNG CXCL8 CSF2
20
Show member pathways
11.82 IL6 CXCL8 CSF3 CSF2
21 11.77 TNF IL6 IFNG CXCL8 CSF2
22 11.74 IL6 IFNG CXCL8 CSF2
23
Show member pathways
11.72 TNF IL6 IFNG
24 11.71 TNF IL6 CXCL8
25
Show member pathways
11.69 TNF IFNG CXCL8 CSF2
26 11.66 TNF IL6 IFNG CSF2
27 11.58 TNF IL6 CXCL8
28 11.55 IL6 IFNG CXCL8
29 11.52 TNF IL6 IFNG
30
Show member pathways
11.52 TNF IL6 IFNG CXCL8 CSF2
31 11.49 IL6 CSF3 CSF2
32 11.45 TNF IL6 IFNG
33 11.35 TNF IL6 IFNG
34 11.35 TNF IL6 IFNG CXCL8 CSF3
35
Show member pathways
11.31 TNF IFNG CSF2 CCL4
36 11.28 TNF IL6 IFNG
37 11.12 TNF IL6 CXCL8 CSF3 CSF2 CCL4
38 11.02 TNF IL6 IFNG CSF3 CSF2
39 10.99 TNF IL6 CXCL8
40 10.97 TNF IL6 EDN1 CXCL8 CSF3 CSF2
41 10.96 TNF IL6 CXCL8 CSF3 CSF2 CCL4

GO Terms for Meconium Aspiration Syndrome

Cellular components related to Meconium Aspiration Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF SFTPB SCGB1A1 PLA2G10 OXT IL6
2 extracellular space GO:0005615 9.47 TNF SFTPB SCGB1A1 PLA2G10 OXT IL6
3 alveolar lamellar body GO:0097208 9.16 SFTPB ABCA3

Biological processes related to Meconium Aspiration Syndrome according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.04 IL6 IFNG EDN1 CSF3 CSF2
2 positive regulation of gene expression GO:0010628 10.02 TNF IL6 IFNG CXCL8 CSF2
3 negative regulation of gene expression GO:0010629 9.98 TNF IFNG EDN1 CXCL8
4 response to drug GO:0042493 9.97 SCGB1A1 EDN1 CPS1 ABCA3
5 regulation of inflammatory response GO:0050727 9.84 ACE2 SCGB1A1 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.84 TNF IL6 IFNG
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 TNF IL6 CSF3
8 cellular response to interleukin-1 GO:0071347 9.82 EDN1 CXCL8 CCL4
9 neutrophil chemotaxis GO:0030593 9.81 EDN1 CXCL8 CCL4
10 regulation of insulin secretion GO:0050796 9.8 TNF IL6 IFNG
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF IL6 EDN1
12 humoral immune response GO:0006959 9.76 TNF IL6 IFNG
13 positive regulation of interleukin-1 beta production GO:0032731 9.75 TNF IL6 IFNG
14 response to activity GO:0014823 9.73 OXT IL6 EDN1
15 cellular response to lipopolysaccharide GO:0071222 9.72 TNF IL6 CXCL8 CSF3 CSF2
16 positive regulation of DNA-binding transcription factor activity GO:0051091 9.71 TNF IL6 EDN1 CSF3
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 TNF IFNG EDN1
18 positive regulation of chemokine production GO:0032722 9.69 TNF IL6 IFNG
19 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.68 TNF IL6
20 positive regulation of renal sodium excretion GO:0035815 9.68 OXT EDN1
21 positive regulation of signaling receptor activity GO:2000273 9.68 IFNG EDN1
22 positive regulation of neuroinflammatory response GO:0150078 9.67 IL6 TNF
23 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 TNF IL6 IFNG CSF2
24 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
25 positive regulation of podosome assembly GO:0071803 9.65 TNF CSF2
26 response to dexamethasone GO:0071548 9.64 EDN1 CPS1
27 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
28 cytokine-mediated signaling pathway GO:0019221 9.63 TNF IL6 CXCL8 CSF3 CSF2 CCL4
29 phosphatidylglycerol metabolic process GO:0046471 9.61 PLA2G10 ABCA3
30 epithelial fluid transport GO:0042045 9.61 EDN1 CSF2
31 vascular endothelial growth factor production GO:0010573 9.6 TNF IL6
32 positive regulation of interleukin-23 production GO:0032747 9.57 IFNG CSF2
33 response to ozone GO:0010193 9.55 SCGB1A1 EDN1
34 histamine secretion GO:0001821 9.54 EDN1 CSF2
35 immune response GO:0006955 9.5 TNF IL6 IFNG CXCL8 CSF3 CSF2
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IFNG
37 response to silicon dioxide GO:0034021 9.48 SCGB1A1 CSF2
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 TNF IFNG
39 positive regulation of nitrogen compound metabolic process GO:0051173 9.43 TNF IFNG
40 positive regulation of prostaglandin secretion GO:0032308 9.43 PLA2G10 OXT EDN1
41 response to glucocorticoid GO:0051384 9.1 TNF SCGB1A1 OXT IL6 CPS1 ABCA3

Molecular functions related to Meconium Aspiration Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 TNF IL6 IFNG EDN1 CXCL8 CSF3

Sources for Meconium Aspiration Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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