Aliases & Classifications for Median Neuropathy

MalaCards integrated aliases for Median Neuropathy:

Name: Median Neuropathy 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:571
ICD10 33 G56.1 G56.10
ICD9CM 35 354.1
MeSH 44 D020423

Summaries for Median Neuropathy

MalaCards based summary : Median Neuropathy is related to carpal tunnel syndrome and neuropathy, and has symptoms including median nerve neuralgia An important gene associated with Median Neuropathy is KNL1 (Kinetochore Scaffold 1). The drugs Lidocaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

Related Diseases for Median Neuropathy

Diseases related to Median Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 carpal tunnel syndrome 11.6
2 neuropathy 10.7
3 mononeuropathy of the median nerve, mild 10.1
4 glomeruloid hemangioma 10.0 MYOM2 VEGFA
5 acroosteolysis 9.9 LMNA VEGFA
6 acromegaly 9.9
7 poems syndrome 9.9 MYOM2 VEGFA
8 mononeuritis of upper limb and mononeuritis multiplex 9.9 KNL1 LMNA MYOM2
9 autosomal genetic disease 9.8 LMNA VEGFA
10 alagille syndrome 1 9.8
11 scleroderma, familial progressive 9.8
12 diabetic neuropathy 9.8
13 hemangioma 9.8
14 amyotrophic neuralgia 9.8
15 capillary hemangioma 9.8
16 arthropathy 9.8
17 thrombophlebitis 9.8
18 radiculopathy 9.8
19 papular mucinosis 9.8

Graphical network of the top 20 diseases related to Median Neuropathy:



Diseases related to Median Neuropathy

Symptoms & Phenotypes for Median Neuropathy

UMLS symptoms related to Median Neuropathy:


median nerve neuralgia

Drugs & Therapeutics for Median Neuropathy

Drugs for Median Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 157)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
2
Bupivacaine Approved, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2921-57-5
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
7
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
8
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
9
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
10
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
11
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
12
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
13
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
14
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
15
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
16 tannic acid Approved Phase 4
17
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
18
Vancomycin Approved Phase 4 1404-90-6 14969 441141
19
Cefazolin Approved Phase 4 25953-19-9 656510 33255
20
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
22
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
23
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 2920-86-7
24 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
26 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
27 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
33 Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
34 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
35 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Not Applicable
36 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
37 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
38 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
40 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
42 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
43 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
44 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
45 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
47 Anticonvulsants Phase 4,Phase 3,Not Applicable
48 Antimanic Agents Phase 4,Phase 3,Not Applicable
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
50 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 200)
# Name Status NCT ID Phase Drugs
1 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
2 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
3 Length of Post Operative Dressing After Carpal Tunnel Release Completed NCT01310218 Phase 4
4 Myofascial Release on Electrophysiological Measures of Pregnant Women With CTS Completed NCT03802448 Phase 4
5 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
6 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
7 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
8 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome Completed NCT00277563 Phase 4
9 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
10 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
11 Onset and Duration of Forearm Nerve Blockade Recruiting NCT03649763 Phase 4 Lidocaine;Bupivacaine;Lidocaine
12 Narcotic vs. Non-narcotic Pain Study Protocol Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
13 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration Active, not recruiting NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
14 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4 Depo-Medrone
15 Preoperative Antibiotics for Carpal Tunnel Release Surgery Not yet recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
16 Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS Not yet recruiting NCT03792945 Phase 4 local injection
17 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Terminated NCT02029235 Phase 4 Acetaminophen/Ibuprofen;Acetaminophen/Hydrocodone
18 Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
19 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Unknown status NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
20 Carpal Tunnel Syndrome Release Using PSU Retractor Unknown status NCT01017471 Phase 3
21 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
22 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
23 Preoperative Gabapentine for Carpal Tunnel Completed NCT01632215 Phase 3 Gabapentine
24 Steroid Injection Treatment of Carpal Tunnel Syndrome Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
25 Gabapentin for Carpal Tunnel Syndrome Completed NCT00137735 Phase 3 Gabapentin
26 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
27 A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
28 Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
29 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
30 Carpal Tunnel Syndrome Treated With 830nm Diode Laser Unknown status NCT00514462 Phase 1, Phase 2
31 A Pilot Study to Evaluate the Effectiveness of Ultrasound Guided Looped Thread Carpal Tunnel Release Completed NCT03476486 Phase 2
32 Acute Human Study: StimRouter for Peripheral Nerve Stimulation of Discrete Peripheral Nerves Completed NCT00665132 Phase 1, Phase 2
33 The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome Completed NCT00634738 Phase 1, Phase 2
34 Percutaneous Treatment of Carpal Tunnel Syndrome With Scan Completed NCT02514317 Phase 2
35 Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome Completed NCT02495298 Phase 2
36 Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Carpal Tunnel Syndrome Undergoing Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
37 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
38 Sham Device, Pill Placebo or Treatment For Arm Pain Completed NCT00029497 Phase 2 Amitriptyline
39 Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Completed NCT00991068 Phase 2 Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
40 The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve Completed NCT00634699 Phase 1, Phase 2
41 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
42 Minocycline to Reduce Pain After Carpal Tunnel Release Completed NCT02051296 Phase 2 Minocycline;placebo
43 Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Completed NCT00929123 Phase 1, Phase 2
44 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2
45 Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2
46 Influence of Pronator Teres Release on Treatment of Median Nerve Compression Neuropathy Recruiting NCT01562860 Phase 2
47 Botulinum Toxin for Carpal Tunnel Syndrome Active, not recruiting NCT00701233 Phase 2 Botulinum toxin;Corticosteroid injection into Carpal Tunnel
48 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Not yet recruiting NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
49 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
50 Hyaluronic Acid Hydro-dissection Use in Idiopathic Carpal Tunnel Syndrome Guided by Ultrasonic Study Recruiting NCT03180125 Phase 1 Sodium Hyaluronate;Sodium Hyaluronate and 1% lidocain;Corticosteroid and 1%lidocain

Search NIH Clinical Center for Median Neuropathy

Cochrane evidence based reviews: median neuropathy

Genetic Tests for Median Neuropathy

Anatomical Context for Median Neuropathy

MalaCards organs/tissues related to Median Neuropathy:

41
Spinal Cord

Publications for Median Neuropathy

Articles related to Median Neuropathy:

(show top 50) (show all 58)
# Title Authors Year
1
Median neuropathy at the wrist in patients with systemic sclerosis: two-year follow-up study. ( 30505011 )
2018
2
Improved Surgical Outcomes With Endoscopic Carpal Tunnel Release in Patients With Severe Median Neuropathy. ( 28453356 )
2017
3
Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy. ( 28477674 )
2017
4
Ultrasonography Detected Missed Lunate Volar Dislocation Associated With Median Neuropathy: A Case Report. ( 28971058 )
2017
5
Brachialis syndrome: a rare consequence of patient positioning causing postoperative median neuropathy. ( 26948003 )
2016
6
Acute Median Neuropathy and Carpal Tunnel Release in Perilunate Injuries Can We Predict Who Gets a Median Neuropathy? ( 26578823 )
2015
7
Proximal median neuropathy caused by surgical manipulation of Masson tumor. ( 24934282 )
2014
8
Median neuropathy at the wrist as an early manifestation of diabetic neuropathy. ( 25422772 )
2014
9
Association between body composition and median neuropathy in patients with physical disabilities. ( 25311882 )
2014
10
How the impact of median neuropathy on sensorimotor control capability of hands for diabetes: an achievable assessment from functional perspectives. ( 24722361 )
2014
11
Impact of distal median neuropathy on handwriting performance for patients with carpal tunnel syndrome in office and administrative support occupations. ( 23934582 )
2014
12
Median neuropathy associated with acupoint stimulation strip. ( 23788738 )
2013
13
Isolated median neuropathy as the first symptom of leprosy. ( 23681846 )
2013
14
Intraneural capillary hemangioma: a rare cause of proximal median neuropathy. ( 24441340 )
2013
15
Computer protocol for the electrodiagnostic evaluation of patients with suspected median neuropathy at the wrist. ( 23690251 )
2013
16
Crucifixion and median neuropathy. ( 23785656 )
2013
17
Median neuropathy in malunited fractures of the distal radius. ( 23864157 )
2013
18
Correlation between subclinical median neuropathy and the cross-sectional area of the median nerve at the wrist. ( 23499346 )
2013
19
Three unusual factors contributing to compressive median neuropathy in the distal forearm in a single patient. ( 22306116 )
2012
20
Median neuropathy caused by giant lipoma in the pronator quadratus: a case report. ( 21873434 )
2011
21
Accuracy of in-office nerve conduction studies for median neuropathy: a meta-analysis. ( 21131139 )
2011
22
Progressive median neuropathy caused by the proximal migration of a retained foreign body (a glass splinter). ( 21719517 )
2011
23
Performance of a repetitive task by aged rats leads to median neuropathy and spinal cord inflammation with associated sensorimotor declines. ( 20673790 )
2010
24
Risk factors for carpal tunnel syndrome and median neuropathy in a working population. ( 19092490 )
2008
25
Electrodiagnosis as an extension of the physical examination: identifying proximal median neuropathy in the setting of carpal tunnel syndrome. ( 18806514 )
2008
26
Ultrasound in the diagnosis of a median neuropathy in the forearm: case report. ( 18053206 )
2007
27
Median-radial sensory nerve comparative studies in the detection of median neuropathy at the wrist in diabetic patients. ( 17452013 )
2007
28
Second lumbrical-interossei latency difference: A strong predictor of median neuropathy at the wrist in uremic patients. ( 17700926 )
2007
29
A carpometacarpal joint ganglion cyst causing median neuropathy. ( 16689518 )
2006
30
Pediatric median neuropathy due to pruritus in Alagille syndrome. ( 16939864 )
2006
31
An unusual case of haemorrhagic median neuropathy. ( 15239866 )
2004
32
Vibration-induced median neuropathy. ( 14557584 )
2003
33
A Bayesian argument against rigid cut-offs in electrodiagnosis of median neuropathy at the wrist. ( 12578927 )
2003
34
Somatosensory evoked potentials for the diagnosis of proximal sensory median neuropathy with preserved distal sensory action potential. ( 14717031 )
2003
35
Perioperative bilateral median neuropathy. ( 12459697 )
2002
36
The pathology of median neuropathy in acromegaly. ( 10906834 )
2000
37
Median neuropathy at the wrist: diagnostic utility of clinical findings and an automated electrodiagnostic device. ( 10774509 )
2000
38
Proximal median neuropathy secondary to humeral neck fracture. ( 10679720 )
2000
39
Bilateral median neuropathy and growth hormone use: a case report. ( 11128896 )
2000
40
Sensory and mixed nerve action potential temporal dispersion in median neuropathy at the wrist. ( 10340417 )
1999
41
Electrodiagnostic reports of median neuropathy at the wrist. ( 9523955 )
1998
42
Venous varix causing median neuropathy. Case illustration. ( 9202280 )
1997
43
Personal factors and blood volume movement in causation of median neuropathy at the carpal tunnel. A commentary. ( 8663933 )
1996
44
Snapping brachialis tendon associated with median neuropathy. A case report. ( 8550659 )
1995
45
Delayed high median neuropathy after supracondylar humeral fracture. A case report and review of the literature. ( 7634676 )
1995
46
Proximal median neuropathy and cervical radiculopathy: double crush revisited. ( 8082604 )
1994
47
Acute median neuropathy after wrist trauma. The role of emergent carpal tunnel release. ( 8131326 )
1994
48
Acute median neuropathy following physeal fractures of the distal radius. ( 8188829 )
1994
49
Papular mucinosis, destructive arthropathy, median neuropathy, and sicca complex. ( 6236018 )
1983
50
Isolated proximal median neuropathy. ( 6283342 )
1982

Variations for Median Neuropathy

Expression for Median Neuropathy

Search GEO for disease gene expression data for Median Neuropathy.

Pathways for Median Neuropathy

GO Terms for Median Neuropathy

Biological processes related to Median Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 8.96 LMNA VEGFA
2 cardiac muscle fiber development GO:0048739 8.62 MYOM2 VEGFA

Sources for Median Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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