MCID: MDN001
MIFTS: 28

Median Rhomboid Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Median Rhomboid Glossitis

MalaCards integrated aliases for Median Rhomboid Glossitis:

Name: Median Rhomboid Glossitis 12 15
Persistent Tuberculum Impar 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14111
ICD10 33 K14.2
ICD9CM 35 529.2
SNOMED-CT 68 7522008
UMLS 73 C0155963

Summaries for Median Rhomboid Glossitis

MalaCards based summary : Median Rhomboid Glossitis, also known as persistent tuberculum impar, is related to fissured tongue and glossitis. An important gene associated with Median Rhomboid Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include tongue.

Wikipedia : 76 Median rhomboid glossitis (MRG, also known as central papillary atrophy, or glossal central papillary... more...

Related Diseases for Median Rhomboid Glossitis

Diseases related to Median Rhomboid Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 fissured tongue 31.2 KRT16 KRT6A
2 glossitis 29.8 KRT16 KRT17 KRT6A KRT6B TTR
3 pachyonychia congenita 1 29.5 KRT16 KRT17 KRT6A KRT6B
4 tongue disease 10.5 KRT6A KRT6B
5 tinea corporis 10.4 KRT16 KRT17
6 steatocystoma multiplex 10.4 KRT16 KRT17
7 epidermoid cysts 10.4 KRT17 KRT6A
8 bowen's disease 10.4 KRT16 KRT17
9 palmoplantar keratoderma, epidermolytic 10.3 KRT16 KRT17
10 geographic tongue 10.3
11 palmoplantar keratoderma, nonepidermolytic 10.3 KRT16 KRT17
12 candidiasis 10.2
13 keratoacanthoma 10.2 KRT16 KRT17
14 primary cutaneous amyloidosis 10.2 KRT16 KRT17
15 sarcoma 10.1
16 hairy tongue 10.1
17 squamous cell carcinoma 10.1
18 white sponge nevus 1 10.1 KRT16 KRT6A KRT6B
19 ichthyosis bullosa of siemens 10.1 KRT16 KRT6A KRT6B
20 tibial neuropathy 10.0 B2M TTR
21 tarsal tunnel syndrome 10.0 B2M TTR
22 pachyonychia congenita 2 10.0 KRT16 KRT17 KRT6B
23 hereditary amyloidosis 10.0 B2M TTR
24 epidermolytic hyperkeratosis 10.0 KRT16 KRT17
25 amyloidosis aa 10.0 B2M TTR
26 nerve compression syndrome 10.0 B2M TTR
27 monilethrix 9.9 KRT16 KRT17 KRT6A
28 amyloid tumor 9.9 B2M TTR
29 skin disease 9.8 KRT16 KRT17 KRT6A
30 kwashiorkor 9.8 TF TTR
31 marasmus 9.8 TF TTR
32 amyloidosis, familial visceral 9.7 B2M TTR
33 keratomalacia 9.7 TF TTR
34 analbuminemia 9.7 TF TTR
35 dysentery 9.7 TF TTR
36 protein-energy malnutrition 9.6 TF TTR
37 carpal tunnel syndrome 9.6 B2M TTR
38 testicular yolk sac tumor 9.6 TF TTR
39 nutritional deficiency disease 9.5 TF TTR
40 vernal conjunctivitis 9.5 B2M TF
41 uremia 9.1 B2M TF
42 retinitis pigmentosa 7 9.1 B2M TF TTR
43 chronic kidney failure 9.1 B2M TF TTR
44 urinary system disease 8.9 B2M TF

Graphical network of the top 20 diseases related to Median Rhomboid Glossitis:



Diseases related to Median Rhomboid Glossitis

Symptoms & Phenotypes for Median Rhomboid Glossitis

Drugs & Therapeutics for Median Rhomboid Glossitis

Search Clinical Trials , NIH Clinical Center for Median Rhomboid Glossitis

Genetic Tests for Median Rhomboid Glossitis

Anatomical Context for Median Rhomboid Glossitis

MalaCards organs/tissues related to Median Rhomboid Glossitis:

41
Tongue

Publications for Median Rhomboid Glossitis

Articles related to Median Rhomboid Glossitis:

(show all 43)
# Title Authors Year
1
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
2
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
3
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
4
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
5
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
6
Median rhomboid glossitis. ( 21446620 )
2011
7
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
8
A classic case of median rhomboid glossitis. ( 19601454 )
2009
9
Partial atrophic tongue other than median rhomboid glossitis. ( 17441970 )
2007
10
Median rhomboid glossitis. ( 17990677 )
2007
11
Pachyonychia congenita associated with median rhomboid glossitis. ( 17511954 )
2007
12
Diagnostic quiz. Case No. 1: median rhomboid glossitis. ( 17632961 )
2006
13
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. ( 15274372 )
2004
14
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
15
A case of median rhomboid glossitis. ( 12773811 )
2003
16
Oral pathology quiz #2. Median rhomboid glossitis. ( 11808366 )
2001
17
Median rhomboid glossitis. ( 8899768 )
1996
18
Median rhomboid glossitis and a "kissing" lesion of the palate. ( 8936507 )
1996
19
Cause of median rhomboid glossitis. ( 8705579 )
1996
20
Median rhomboid glossitis. An oral manifestation in patients infected with HIV. ( 8078660 )
1994
21
Squamous cell carcinoma mimicking median rhomboid glossitis region: report of a case. ( 8509924 )
1993
22
Quantitative evaluation of Langerhans cells in median rhomboid glossitis. ( 1593492 )
1992
23
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). ( 1841980 )
1991
24
Median rhomboid glossitis: review of a puzzling entity. ( 2097050 )
1990
25
Median rhomboid glossitis. A follow-up study of 16 patients. ( 3459824 )
1986
26
Candida albicans in median rhomboid glossitis. A postmortem study. ( 3088163 )
1986
27
Median rhomboid glossitis in an infant. Report of a case. ( 3861810 )
1985
28
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. ( 6438002 )
1984
29
Chronic candidiasis of the rat tongue: a possible model for human median rhomboid glossitis. ( 6958728 )
1982
30
Median rhomboid glossitis caused by Candida? ( 282562 )
1979
31
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. ( 366496 )
1978
32
Median rhomboid glossitis associated with amyloid deposition. ( 676752 )
1978
33
Carcinoma arising in the area of median rhomboid glossitis. ( 1063965 )
1976
34
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. ( 1201190 )
1975
35
Median rhomboid glossitis. Case report. ( 4713826 )
1973
36
Median rhomboid glossitis: a developmental anomaly? ( 5275506 )
1971
37
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. ( 5270895 )
1970
38
Median rhomboid glossitis. Case report. ( 5353692 )
1969
39
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. ( 5245682 )
1968
40
Median rhomboid glossitis: an atypical variant. ( 5234276 )
1967
41
Median rhomboid glossitis; case reported in an infant. ( 13125261 )
1954
42
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. ( 13088005 )
1953
43
Median rhomboid glossitis; report of a case. ( 13013723 )
1952

Variations for Median Rhomboid Glossitis

Expression for Median Rhomboid Glossitis

Search GEO for disease gene expression data for Median Rhomboid Glossitis.

Pathways for Median Rhomboid Glossitis

Pathways related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 KRT17 KRT6A KRT6B
2
Show member pathways
11.38 KRT16 KRT17 KRT6A KRT6B
3
Show member pathways
11.17 KRT16 KRT17 KRT6A

GO Terms for Median Rhomboid Glossitis

Cellular components related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.5 B2M KRT16 KRT17 KRT6A KRT6B TF
2 HFE-transferrin receptor complex GO:1990712 9.16 B2M TF
3 intermediate filament GO:0005882 8.92 KRT16 KRT17 KRT6A KRT6B

Biological processes related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.65 B2M TF TTR
2 cytoskeleton organization GO:0007010 9.61 KRT16 KRT6A KRT6B
3 retina homeostasis GO:0001895 9.51 B2M TF
4 iron ion homeostasis GO:0055072 9.49 B2M TF
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.46 B2M TF
6 morphogenesis of an epithelium GO:0002009 9.4 KRT16 KRT6A
7 intermediate filament cytoskeleton organization GO:0045104 9.37 KRT16 KRT6A
8 iron ion transport GO:0006826 9.32 B2M TF
9 cellular response to iron ion GO:0071281 9.26 B2M TF
10 keratinization GO:0031424 9.26 KRT16 KRT17 KRT6A KRT6B
11 regulation of iron ion import GO:1900390 9.16 B2M TF
12 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT16 KRT17 KRT6A
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B

Sources for Median Rhomboid Glossitis

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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45 MESH via Orphanet
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54 NINDS
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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