MCID: MDN001
MIFTS: 30

Median Rhomboid Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Median Rhomboid Glossitis

MalaCards integrated aliases for Median Rhomboid Glossitis:

Name: Median Rhomboid Glossitis 12 15
Persistent Tuberculum Impar 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14111
ICD10 33 K14.2
ICD9CM 35 529.2
SNOMED-CT 68 7522008
UMLS 73 C0155963

Summaries for Median Rhomboid Glossitis

MalaCards based summary : Median Rhomboid Glossitis, also known as persistent tuberculum impar, is related to glossitis and fissured tongue. An important gene associated with Median Rhomboid Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include tongue, skin and kidney, and related phenotype is digestive/alimentary.

Wikipedia : 76 Median rhomboid glossitis (MRG, also known as central papillary atrophy, or glossal central papillary... more...

Related Diseases for Median Rhomboid Glossitis

Diseases related to Median Rhomboid Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 glossitis 31.3 KRT17 KRT6A KRT6B TTR
2 fissured tongue 30.9 KRT16 KRT6A
3 pachyonychia congenita 1 30.1 KRT16 KRT17 KRT6A KRT6B
4 geographic tongue 10.5
5 candidiasis 10.4
6 sarcoma 10.2
7 hairy tongue 10.2
8 squamous cell carcinoma 10.2
9 pachyonychia congenita 2 10.1 KRT17 KRT6B
10 palmoplantar keratoderma, bothnian type 10.1 KRT16 KRT17
11 tinea corporis 10.1 KRT16 KRT17
12 steatocystoma multiplex 10.1 KRT16 KRT17
13 bowen's disease 10.1 KRT16 KRT17
14 epidermoid cysts 10.1 KRT17 KRT6A
15 keratoacanthoma 10.1 KRT16 KRT17
16 primary cutaneous amyloidosis 10.1 KRT16 KRT17
17 white sponge nevus 1 10.0 KRT16 KRT6A KRT6B
18 al amyloidosis 10.0 B2M TTR
19 tibial neuropathy 10.0 B2M TTR
20 tarsal tunnel syndrome 10.0 B2M TTR
21 amyloid tumor 10.0 B2M TTR
22 hereditary amyloidosis 10.0 B2M TTR
23 monilethrix 10.0 KRT16 KRT17 KRT6A
24 nerve compression syndrome 10.0 B2M TTR
25 epidermolytic hyperkeratosis 10.0 KRT16 KRT17 KRT6A
26 amyloidosis aa 10.0 B2M TTR
27 amyloidosis, familial visceral 9.9 B2M TTR
28 keratomalacia 9.9 TF TTR
29 marasmus 9.9 TF TTR
30 carpal tunnel syndrome 9.9 B2M TTR
31 kwashiorkor 9.9 TF TTR
32 analbuminemia 9.9 TF TTR
33 dysentery 9.9 TF TTR
34 protein-energy malnutrition 9.9 TF TTR
35 testicular yolk sac tumor 9.9 TF TTR
36 vernal conjunctivitis 9.9 B2M TF
37 nutritional deficiency disease 9.8 TF TTR
38 uremia 9.8 B2M TF
39 skin disease 9.8 B2M KRT16 KRT17 KRT6A
40 membranous nephropathy 9.7 B2M TF
41 retinitis pigmentosa 7 9.7 B2M TF TTR
42 chronic kidney failure 9.7 B2M TF TTR
43 urinary system disease 9.6 B2M TF
44 kidney disease 9.6 B2M TF TTR

Graphical network of the top 20 diseases related to Median Rhomboid Glossitis:



Diseases related to Median Rhomboid Glossitis

Symptoms & Phenotypes for Median Rhomboid Glossitis

MGI Mouse Phenotypes related to Median Rhomboid Glossitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 B2M KRT16 KRT17 KRT6B TTR

Drugs & Therapeutics for Median Rhomboid Glossitis

Search Clinical Trials , NIH Clinical Center for Median Rhomboid Glossitis

Genetic Tests for Median Rhomboid Glossitis

Anatomical Context for Median Rhomboid Glossitis

MalaCards organs/tissues related to Median Rhomboid Glossitis:

41
Tongue, Skin, Kidney

Publications for Median Rhomboid Glossitis

Articles related to Median Rhomboid Glossitis:

(show all 44)
# Title Authors Year
1
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
2
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
3
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
4
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
5
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
6
Median rhomboid glossitis. ( 21446620 )
2011
7
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
8
A classic case of median rhomboid glossitis. ( 19601454 )
2009
9
Partial atrophic tongue other than median rhomboid glossitis. ( 17441970 )
2007
10
Median rhomboid glossitis. ( 17990677 )
2007
11
Pachyonychia congenita associated with median rhomboid glossitis. ( 17511954 )
2007
12
Diagnostic quiz. Case No. 1: median rhomboid glossitis. ( 17632961 )
2006
13
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. ( 15274372 )
2004
14
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
15
A case of median rhomboid glossitis. ( 12773811 )
2003
16
Oral pathology quiz #2. Median rhomboid glossitis. ( 11808366 )
2001
17
Median rhomboid glossitis. ( 8899768 )
1996
18
Median rhomboid glossitis and a "kissing" lesion of the palate. ( 8936507 )
1996
19
Cause of median rhomboid glossitis. ( 8705579 )
1996
20
Revival of "median rhomboid glossitis"? ( 7552855 )
1995
21
Median rhomboid glossitis. An oral manifestation in patients infected with HIV. ( 8078660 )
1994
22
Squamous cell carcinoma mimicking median rhomboid glossitis region: report of a case. ( 8509924 )
1993
23
Quantitative evaluation of Langerhans cells in median rhomboid glossitis. ( 1593492 )
1992
24
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). ( 1841980 )
1991
25
Median rhomboid glossitis: review of a puzzling entity. ( 2097050 )
1990
26
Median rhomboid glossitis. A follow-up study of 16 patients. ( 3459824 )
1986
27
Candida albicans in median rhomboid glossitis. A postmortem study. ( 3088163 )
1986
28
Median rhomboid glossitis in an infant. Report of a case. ( 3861810 )
1985
29
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. ( 6438002 )
1984
30
Chronic candidiasis of the rat tongue: a possible model for human median rhomboid glossitis. ( 6958728 )
1982
31
Median rhomboid glossitis caused by Candida? ( 282562 )
1979
32
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. ( 366496 )
1978
33
Median rhomboid glossitis associated with amyloid deposition. ( 676752 )
1978
34
Carcinoma arising in the area of median rhomboid glossitis. ( 1063965 )
1976
35
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. ( 1201190 )
1975
36
Median rhomboid glossitis. Case report. ( 4713826 )
1973
37
Median rhomboid glossitis: a developmental anomaly? ( 5275506 )
1971
38
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. ( 5270895 )
1970
39
Median rhomboid glossitis. Case report. ( 5353692 )
1969
40
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. ( 5245682 )
1968
41
Median rhomboid glossitis: an atypical variant. ( 5234276 )
1967
42
Median rhomboid glossitis; case reported in an infant. ( 13125261 )
1954
43
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. ( 13088005 )
1953
44
Median rhomboid glossitis; report of a case. ( 13013723 )
1952

Variations for Median Rhomboid Glossitis

Expression for Median Rhomboid Glossitis

Search GEO for disease gene expression data for Median Rhomboid Glossitis.

Pathways for Median Rhomboid Glossitis

Pathways related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 KRT17 KRT6A KRT6B
2
Show member pathways
11.38 KRT16 KRT17 KRT6A KRT6B
3
Show member pathways
11.17 KRT16 KRT17 KRT6A

GO Terms for Median Rhomboid Glossitis

Cellular components related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.26 KRT6A KRT6B
2 intermediate filament GO:0005882 9.26 KRT16 KRT17 KRT6A KRT6B
3 extracellular exosome GO:0070062 9.17 B2M KRT16 KRT17 KRT6A KRT6B TF
4 HFE-transferrin receptor complex GO:1990712 9.16 B2M TF

Biological processes related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.63 B2M TF TTR
2 retina homeostasis GO:0001895 9.49 B2M TF
3 iron ion homeostasis GO:0055072 9.48 B2M TF
4 keratinization GO:0031424 9.46 KRT16 KRT17 KRT6A KRT6B
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.43 B2M TF
6 morphogenesis of an epithelium GO:0002009 9.4 KRT16 KRT6A
7 iron ion transport GO:0006826 9.37 B2M TF
8 cellular response to iron ion GO:0071281 9.32 B2M TF
9 regulation of iron ion import GO:1900390 9.26 B2M TF
10 cytoskeleton organization GO:0007010 9.26 KRT16 KRT17 KRT6A KRT6B
11 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Median Rhomboid Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.76 B2M KRT16 KRT17 KRT6A KRT6B TF
2 structural molecule activity GO:0005198 9.13 KRT16 KRT17 KRT6A
3 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B

Sources for Median Rhomboid Glossitis

3 CDC
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10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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54 NINDS
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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