MCID: MDS018
MIFTS: 40

Mediastinal Cancer

Categories: Cancer diseases

Aliases & Classifications for Mediastinal Cancer

MalaCards integrated aliases for Mediastinal Cancer:

Name: Mediastinal Cancer 12 15 17
Mediastinal Neoplasms 44 70
Malignant Tumor of Mediastinum 70
Neoplasm of Mediastinum 12
Tumour of Mediastinum 12
Mediastinum Cancer 12
Mediastinal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5559
ICD9CM 34 164.9
MeSH 44 D008479
NCIt 50 C3221 C3549
SNOMED-CT 67 363494000 94147001
ICD10 32 C38.3
UMLS 70 C0025063 C0153504

Summaries for Mediastinal Cancer

Disease Ontology : 12 A thoracic cancer that is located in the mediastinum.

MalaCards based summary : Mediastinal Cancer, also known as mediastinal neoplasms, is related to neurilemmoma and seminoma. An important gene associated with Mediastinal Cancer is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic cell lineage. The drugs Etoposide and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, heart and liver, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Mediastinal Cancer

Diseases related to Mediastinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 717)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 30.6 KIT ENO2 CD34
2 seminoma 30.5 TNFRSF8 KIT ENO2 AFP
3 neurofibroma 30.4 SYP KIT CD34
4 thymoma 30.3 SYP PTPRC NKX2-1 KIT CD5
5 carcinoid syndrome 30.3 SYP ENO2 CHGA
6 thymic epithelial tumor 30.3 KIT CD5
7 ganglioneuroma 30.2 SYP NCAM1 ENO2 CHGA
8 fibrous histiocytoma 30.1 KIT ENO2 CD34
9 benign mesothelioma 30.0 NKX2-1 KRT7 CEACAM5
10 clear cell sarcoma 30.0 SYP KIT ENO2
11 germ cell cancer 29.9 KIT FUT4 ENO2 AFP
12 hemangiopericytoma, malignant 29.8 SYP KIT ENO2 CD34
13 spindle cell sarcoma 29.8 NUTM1 KRT7 KIT CD34
14 reticulum cell sarcoma 29.8 TNFRSF8 PTPRC
15 lymphosarcoma 29.8 TNFRSF8 PTPRC
16 pancytopenia 29.7 NCAM1 KIT CD5 CD34
17 neurofibromatosis, type i 29.7 NCAM1 KIT ENO2 CD34
18 paraganglioma 29.7 SYP NCAM1 KIT ENO2 CHGA
19 sarcoma, synovial 29.6 TNFRSF8 KRT7 KIT CD34
20 acute leukemia 29.6 PAX5 NCAM1 KIT CD34
21 cystic teratoma 29.5 SYP NKX2-1 KRT7 KIT ENO2
22 papillary carcinoma 29.4 SYP NKX2-1 KRT7 CHGA
23 neuroendocrine tumor 29.4 SYP NKX2-1 NCAM1 ENO2 CHGA
24 lymphoblastic lymphoma 29.3 TNFRSF8 PTPRC PAX5 CD5
25 mature teratoma 29.3 TNFRSF8 SYP KRT7 KIT ENO2 CEACAM5
26 cavernous hemangioma 29.3 SYP NKX2-1 KRT7 KIT CD34
27 reticulosarcoma 29.3 TNFRSF8 PTPRC PAX5
28 gastrointestinal stromal tumor 29.2 SYP NCAM1 KIT ENO2 CHGA CD34
29 teratoma 29.2 SYP NKX2-1 KRT7 KIT ENO2 CHGA
30 endodermal sinus tumor 29.2 TNFRSF8 KRT7 CHGA CEACAM5 AFP
31 thymic carcinoma 29.1 SYP NKX2-1 KRT7 KIT ENO2 CEACAM5
32 lymphoma, hodgkin, classic 29.0 TNFRSF8 PTPRC PAX5
33 hemangioma 29.0 SYP NKX2-1 KRT7 KIT ENO2 CHGA
34 diffuse large b-cell lymphoma 28.9 TNFRSF8 PTPRC PAX5 CD79A CD5
35 myeloid sarcoma 28.8 PTPRC PAX5 NCAM1 KIT CD79A CD34
36 leukemia, acute lymphoblastic 28.6 TNFRSF8 PTPRC PAX5 NCAM1 KIT CD5
37 plasmacytoma 28.6 SYP PTPRC PAX5 NCAM1 CD79A CD5
38 lymphoma, non-hodgkin, familial 28.4 TNFRSF8 PTPRC PAX5 NCAM1 CD79A CD5
39 small cell carcinoma 28.2 SYP PTPRC NKX2-1 NCAM1 KRT7 KIT
40 rhabdomyosarcoma 27.9 SYP PTPRC PAX5 NCAM1 KRT7 KIT
41 neuroendocrine carcinoma 27.1 SYP PTPRC PAX5 NKX2-1 NCAM1 KRT7
42 childhood mediastinal neurogenic tumor 11.2
43 mediastinal mesenchymal tumor 11.2
44 posterior mediastinum cancer 11.1
45 malignant mediastinal neurogenic neoplasm 11.0
46 thymoma, familial 10.5
47 bladder lymphoma 10.4 CD79A CD5
48 glomangioma 10.4 SYP CD34
49 mediastinum seminoma 10.4 KIT AFP
50 mixed germ cell tumor 10.4 KIT AFP

Graphical network of the top 20 diseases related to Mediastinal Cancer:



Diseases related to Mediastinal Cancer

Symptoms & Phenotypes for Mediastinal Cancer

GenomeRNAi Phenotypes related to Mediastinal Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 AFP CD34 CD5 CD79A CHGA KRT7

MGI Mouse Phenotypes related to Mediastinal Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 AFP CD34 CD79A KIT NKX2-1 PAX5

Drugs & Therapeutics for Mediastinal Cancer

Drugs for Mediastinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 4 33419-42-0 36462
2
Ifosfamide Approved Phase 4 3778-73-2 3690
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
7
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
8
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
9
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
10
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
11
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
12
Cytarabine Approved, Investigational Phase 4 147-94-4 6253
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
14
Vindesine Approved, Investigational Phase 4 59917-39-4, 53643-48-4 40839
15
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
16
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
17
rituximab Approved Phase 4 174722-31-7 10201696
18
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
19
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
20 Antibiotics, Antitubercular Phase 4
21 Etoposide phosphate Phase 4
22 Alkylating Agents Phase 4
23 Anti-Bacterial Agents Phase 4
24
Isophosphamide mustard Phase 4 100427
25 Tubulin Modulators Phase 4
26 Antimitotic Agents Phase 4
27 Antineoplastic Agents, Immunological Phase 4
28 Vitamin B9 Phase 4
29 Gastrointestinal Agents Phase 4
30 Antiemetics Phase 4
31 Immunosuppressive Agents Phase 4
32 Methylprednisolone Acetate Phase 4
33 Anti-Infective Agents Phase 4
34
Liposomal doxorubicin Phase 4 31703
35 Antirheumatic Agents Phase 4
36 Immunologic Factors Phase 4
37 Folic Acid Antagonists Phase 4
38 Antineoplastic Agents, Hormonal Phase 4
39 Hormones Phase 4
40 Vitamin B Complex Phase 4
41 Hormone Antagonists Phase 4
42 Antiviral Agents Phase 4
43 Folate Phase 4
44 Dermatologic Agents Phase 4
45 Antimetabolites Phase 4
46 glucocorticoids Phase 4
47 Anti-Inflammatory Agents Phase 4
48
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
49
Lenograstim Approved, Investigational Phase 3 135968-09-1
50
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7) Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
2 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
3 Postoperative Pain and Quality of Life for Patients Undergoing Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS:A Randomized Controlled Trial Recruiting NCT03521986 Phase 3
4 Comparison of Safety and Efficacy Among "3-Hole" Subxiphorid Approach, Trans Sternal Approach and VATS in Surgical Treatment of Anterior Mediastinal Tumor Recruiting NCT02317224 Phase 2
5 Phase 2 Study of Weekly Topotecan With Docetaxel for Recurrent Small Cell Lung Cancer Terminated NCT00315211 Phase 2 Intravenous Topotecan;Intravenous Docetaxel
6 A Phase II Single-Arm Multi-Center Trial Evaluating the Efficacy of Pembrolizumab in the Treatment of Subjects With Incurable Platinum-Refractory Germ Cell Tumors: Hoosier Cancer Research Network GU14-206 Terminated NCT02499952 Phase 2 Pembrolizumab
7 Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging Unknown status NCT03214341
8 Development and Evaluation of Clinical Utility of Virtual Bronchoscopy (VB)-Based System for Bronchoscopic Navigation, Mediastinal Mapping and Transbronchial Aspiration of Mediastinal Lesions. Unknown status NCT01784185
9 Totally no Tube (TNT) Uniportal Video-assisted Thoracoscopic Surgery (VATS) VS Traditional Uniportal VATS for Mediastinal Tumor: A Prospective Randomized Controlled Trial Completed NCT03537430
10 Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation Completed NCT02220231
11 Needlescopic-assisted Uniportal VATS Versus Conventional Uniportal VATS. A Randomized Prospective Noninferiority Study Completed NCT03439696
12 Multicenter Randomized Controlled Trial Comparing the Performance of 22 Gauge Versus 25 Gauge EUS-FNA Needles Completed NCT01016288
13 Establishment of Personalized Cancer Medicine Using Samsung Cancer Sequencing Platform in Lung Cancer/Mediastinal Tumor/ Head & Neck/Esophageal Cancer/Rare Cancer (PerSeq: Personalized Sequence) Recruiting NCT02299622
14 A Prospective Multicenter Comparative Study of the Curative Effect of Extended Thymectomy Performed Through the Subxiphoid VATS Approach With Double Elevation of the Sternum Versus Intercostal VATS Approach Recruiting NCT03613272

Search NIH Clinical Center for Mediastinal Cancer

Cochrane evidence based reviews: mediastinal neoplasms

Genetic Tests for Mediastinal Cancer

Anatomical Context for Mediastinal Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinal Cancer:

19
Mediastinum

MalaCards organs/tissues related to Mediastinal Cancer:

40
Heart, Liver, Thymus, Prostate, Trachea

Publications for Mediastinal Cancer

Articles related to Mediastinal Cancer:

(show top 50) (show all 179)
# Title Authors PMID Year
1
Carcinoid tumor of the anterior mediastinum in a 38-year-old woman. 61
32874403 2020
2
Venoarterial Extracorporeal Membrane Oxygenation Support Rescue of Obstructive Shock Caused by Bulky Compressive Mediastinal Cancer. 61
32543883 2020
3
National prevalence, trends and outcomes of takotsubo syndrome in hospitalizations with prior history of mediastinal/intrathoracic cancer and radiation therapy. 61
32087939 2020
4
The importance of postoperative analgesia after major thoracic surgery interventions, protocols, applications, and the following evaluation of the patient's quality of life. 61
31802050 2019
5
Pediatric Chest MRI: A Review. 61
30719641 2019
6
Primary mediastinal neoplasms: a report of 1,005 cases from a single institution. 61
31372287 2019
7
Distinguishing thymoma from T-lymphoblastic leukaemia/lymphoma: a case-based evaluation. 61
30467242 2019
8
A clinical trial of intraoperative near-infrared imaging to assess tumor extent and identify residual disease during anterior mediastinal tumor resection. 61
30561757 2019
9
[The processes of lipoperoxidation and endogenous intoxication in saliva in central and peripheral lung cancer.] 61
31185148 2019
10
Near-infrared intraoperative imaging during resection of an anterior mediastinal soft tissue sarcoma. 61
29387401 2018
11
Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review. 61
28747182 2017
12
Neovascularization of Thymoma From Left Internal Mammary Artery Bypass Graft. 61
28219559 2017
13
Effect of compound Zhuye Shigao Granule ( ) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial. 61
28035542 2017
14
Spectrum of cancer risk among Taiwanese with chronic obstructive pulmonary disease. 61
27154177 2016
15
[Non-neoplastic lesions of the mediastinum]. 61
27465275 2016
16
[Mediastinal germ cell tumors]. 61
27491549 2016
17
[Thymomas]. 61
27558364 2016
18
Stereotactic ablative radiotherapy with CyberKnife for advanced thymic carcinoma: a case report. 61
26628883 2015
19
Isolated cardiac metastasis from squamous cell esophageal cancer. 61
26045127 2015
20
Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature. 61
29404085 2015
21
Single-nucleotide polymorphisms of TGFβ1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China. 61
26629166 2015
22
Utility of immunohistochemistry in the diagnosis of pleuropulmonary and mediastinal cancers: a review and update. 61
25427041 2014
23
Advances in thymic carcinoma diagnosis and treatment: a review of literature. 61
24906655 2014
24
Historical perspectives: The evolution of the thymic epithelial tumors staging system. 61
24377980 2014
25
Surgical Approaches for Stage IVA Thymic Epithelial Tumors. 61
24459636 2014
26
Mediastinal seminoma: a case report with special emphasis on SALL4 as a new immunocytochemical marker. 61
22298374 2013
27
18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study. 61
22055682 2012
28
Pathologic characteristics of NUT midline carcinoma arising in the mediastinum. 61
22790861 2012
29
[Thoracic surgery in patients with autoimmune diseases]. 61
22868439 2012
30
The role of positron emission tomography using carbon-11 and fluorine-18 choline in tumors other than prostate cancer: a systematic review. 61
22566040 2012
31
Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia? 61
22824515 2012
32
Survival in cancer of unknown primary site: population-based analysis by site and histology. 61
22115926 2012
33
Metaplastic thymoma: report of 4 cases. 61
23109986 2012
34
Chylopericardium Secondary to Lymphangiomyoma - A case report -. 61
22263193 2011
35
Pax8 expression in thymic epithelial neoplasms: an immunohistochemical analysis. 61
21836478 2011
36
[Mediastinal cancer presenting as dermatomyositis--a case report]. 61
21874766 2011
37
Spindle cell thymomas (WHO Type A) with prominent papillary and pseudopapillary features: a clinicopathologic and immunohistochemical study of 10 cases. 61
21317709 2011
38
Primary angiosarcomas of the anterior mediastinum: a clinicopathologic and immunohistochemical study of 9 cases. 61
20709359 2010
39
Video-assisted thoracoscopic surgery for a cystic seminoma of the mediastinum. 61
21095363 2010
40
Mental neuropathy (numb chin syndrome) leading to diagnosis of metastatic mediastinal cancer. 61
20592385 2010
41
[INTRAOPERATIVE ULTRASOUND DIAGNOSIS OF MEDIASTINAL NEOPLASMS]. 61
27529941 2010
42
Comparison of EUS-guided FNA and Trucut biopsy for diagnosing and staging abdominal and mediastinal neoplasms. 61
19217057 2009
43
[A case of mediastinal cancer of unknown primary with elevation of serum concentrations of interleukin-6]. 61
18931593 2008
44
Cytology of metastatic thymic well-differentiated neuroendocrine carcinoma (thymic carcinoid) in pleural fluid: report of a case. 61
18418883 2008
45
Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases. 61
18162782 2008
46
[Ultrasound guided transthoracic biopsy - safety and efficaces]. 61
17602390 2007
47
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. 61
17536551 2007
48
Imaging of an invasive malignant thymoma on PET Scan: CT and histopathologic correlation. 61
16985366 2006
49
The diagnostic value of image guided percutaneous fine needle aspiration biopsy in equivocal mediastinal masses. 61
16534651 2006
50
The anterior mediastinum: anatomy and imaging procedures. 61
16683080 2006

Variations for Mediastinal Cancer

Expression for Mediastinal Cancer

Search GEO for disease gene expression data for Mediastinal Cancer.

Pathways for Mediastinal Cancer

GO Terms for Mediastinal Cancer

Cellular components related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 PTPRC NCAM1 KIT FUT4 CEACAM5 CD34
2 cell periphery GO:0071944 9.33 PTPRC FUT4 CD34
3 external side of plasma membrane GO:0009897 9.1 PTPRC NCAM1 KIT CD79A CD5 CD34

Biological processes related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.33 PTPRC KIT CD79A
2 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
3 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Sources for Mediastinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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