MCID: MDS018
MIFTS: 37

Mediastinal Cancer

Categories: Cancer diseases

Aliases & Classifications for Mediastinal Cancer

MalaCards integrated aliases for Mediastinal Cancer:

Name: Mediastinal Cancer 12 15
Mediastinal Neoplasms 44 73
Malignant Tumor of Mediastinum 73
Neoplasm of Mediastinum 12
Tumour of Mediastinum 12
Mediastinum Cancer 12
Mediastinal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5559
ICD10 33 C38.3
ICD9CM 35 164.9
MeSH 44 D008479
NCIt 50 C3221 C3549

Summaries for Mediastinal Cancer

Disease Ontology : 12 A thoracic cancer that is located in the mediastinum.

MalaCards based summary : Mediastinal Cancer, also known as mediastinal neoplasms, is related to posterior mediastinum cancer and anemia, congenital dyserythropoietic, type ii. An important gene associated with Mediastinal Cancer is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Neuroscience and Hematopoietic cell lineage. The drugs rituximab and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include the mediastinum, lung and b cells.

Related Diseases for Mediastinal Cancer

Diseases related to Mediastinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 posterior mediastinum cancer 11.9
2 anemia, congenital dyserythropoietic, type ii 11.0
3 malignant mediastinal neurogenic neoplasm 11.0
4 liver lymphoma 10.8 AFP SMUG1
5 extragonadal nonseminomatous germ cell tumor 10.8 AFP SMUG1
6 sternum cancer 10.8 AFP SMUG1
7 corpus luteum cyst 10.8 AFP SMUG1
8 extragonadal germ cell cancer 10.8 AFP SMUG1
9 oculomotor nerve paralysis 10.8 AFP SMUG1
10 third cranial nerve disease 10.8 AFP SMUG1
11 scrotal carcinoma 10.7 AFP SMUG1
12 malignant sertoli cell tumor 10.7 AFP SYP
13 mature teratoma 10.7 AFP SMUG1
14 prostate lymphoma 10.7 CD5 SMUG1
15 cellular ependymoma 10.7 SMUG1 SYP
16 malignant teratoma 10.7 AFP SYP
17 gastrointestinal neuroendocrine tumor 10.7 SMUG1 SYP
18 adult lymphoma 10.7 CD5 SMUG1
19 seminal vesicle tumor 10.7 AFP SYP
20 pancreatoblastoma 10.7 AFP SYP
21 pineoblastoma 10.6 AFP SYP
22 peliosis hepatis 10.6 AFP SMUG1
23 pancreatic cystadenocarcinoma 10.6 AFP SYP
24 immune system organ benign neoplasm 10.6 CD5 SYP
25 thymus lipoma 10.6 CD5 SYP
26 mixed germ cell tumor 10.6 AFP KIT
27 hepatic angiomyolipoma 10.5 AFP KIT
28 ectopic cushing syndrome 10.5 SMUG1 SYP
29 intratubular embryonal carcinoma 10.5 AFP KIT
30 thymic epithelial tumor 10.5 CD5 KIT
31 rete testis adenocarcinoma 10.5 AFP KIT
32 testicular infarct 10.5 AFP KIT
33 granulomatous myositis 10.5 NCAM1 SMUG1
34 esophageal neuroendocrine tumor 10.5 NCAM1 SYP
35 ovarian large-cell neuroendocrine carcinoma 10.5 NCAM1 SYP
36 lung combined type small cell carcinoma 10.5 NCAM1 SYP
37 sensory organ benign neoplasm 10.5 NCAM1 SYP
38 extrahepatic bile duct adenocarcinoma 10.5 NCAM1 SYP
39 orbital cancer 10.4 NCAM1 SYP
40 heart sarcoma 10.4 KIT SMUG1
41 hypoganglionosis 10.4 NCAM1 SYP
42 sex cord-gonadal stromal tumor 10.4 AFP SYP
43 pancreatic endocrine carcinoma 10.4 NCAM1 SYP
44 hepatic vascular disease 10.4 AFP CD33
45 pancreatic serous cystadenoma 10.4 NCAM1 SYP
46 cystadenofibroma 10.4 AFP NCAM1
47 conventional angiosarcoma 10.4 NCAM1 SYP
48 extragonadal seminoma 10.4 AFP KIT
49 supratentorial primitive neuroectodermal tumor 10.4 NCAM1 SYP
50 gastric squamous cell carcinoma 10.4 NCAM1 SYP

Graphical network of the top 20 diseases related to Mediastinal Cancer:



Diseases related to Mediastinal Cancer

Symptoms & Phenotypes for Mediastinal Cancer

Drugs & Therapeutics for Mediastinal Cancer

Drugs for Mediastinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 4 174722-31-7 10201696
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Ifosfamide Approved Phase 4,Phase 3 3778-73-2 3690
4
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
5
Cytarabine Approved, Investigational Phase 4 147-94-4 6253
6
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
7
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
9
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
12
Racepinephrine Approved Phase 4 329-65-7 838
13
Etoposide Approved Phase 4,Phase 3 33419-42-0 36462
14
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
15
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
16
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
17
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
18
Vindesine Approved, Investigational Phase 4 59917-39-4, 53643-48-4 40839
19
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
21
Doxil Approved June 1999 Phase 4 31703
22 Dexamethasone acetate Phase 4 1177-87-3
23
Isophosphamide mustard Phase 4,Phase 3 0
24 Analgesics Phase 4
25 Alkylating Agents Phase 4,Phase 3
26 Central Nervous System Depressants Phase 4
27 Adrenergic Agents Phase 4
28 Adrenergic Agonists Phase 4
29 Adrenergic alpha-2 Receptor Agonists Phase 4
30 Adrenergic alpha-Agonists Phase 4
31 Narcotics Phase 4
32 Neurotransmitter Agents Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Analgesics, Opioid Phase 4
35 Anesthetics Phase 4
36 Anesthetics, General Phase 4
37 Anesthetics, Intravenous Phase 4
38 Peripheral Nervous System Agents Phase 4
39 Epinephryl borate Phase 4
40 Hypnotics and Sedatives Phase 4
41 Immunosuppressive Agents Phase 4
42 Antirheumatic Agents Phase 4
43 BB 1101 Phase 4
44 Antineoplastic Agents, Alkylating Phase 4,Phase 3
45 Prednisolone acetate Phase 4
46 glucocorticoids Phase 4
47 Methylprednisolone acetate Phase 4
48 Methylprednisolone Hemisuccinate Phase 4
49 Folic Acid Antagonists Phase 4
50 Gastrointestinal Agents Phase 4

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Safety Evaluation of Dexmedetomidine for EBUS-TBNA Unknown status NCT01381627 Phase 4 Remifentanil;Dexmedetomidine
2 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
3 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
4 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
5 Pain and Quality of Life After Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS Recruiting NCT03521986 Phase 3
6 Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage Completed NCT00589290 Phase 2 Belinostat (PDX101)
7 Intravenous Indocyanine Green for Localization of Intra-thoracic Lesions Completed NCT03097627 Phase 1, Phase 2 ICG Intervention
8 Mithramycin for Lung, Esophagus, and Other Chest Cancers Recruiting NCT01624090 Phase 2 Mithramycin
9 The Safety and Efficacy of "3-Hole" Subxiphorid Approach in the Treatment of Anterior Mediastinal Tumor Recruiting NCT02317224 Phase 2
10 Radiotherapy Delivery in Deep Inspiration for Pediatric Patients Recruiting NCT03315546 Phase 1, Phase 2
11 Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer Terminated NCT00315211 Phase 2 Intravenous Topotecan;Intravenous Docetaxel
12 Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors Terminated NCT02499952 Phase 2 Pembrolizumab
13 Personalized Sequence for Thoracic, Esophageal, and H&N Cancer Unknown status NCT02299622
14 Virtual Bronchoscopy (VB) vs. Endobronchial Ultrasound (EBUS) Guided Mediastinal Sampling Unknown status NCT01784185 Not Applicable
15 Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation Completed NCT02220231 Not Applicable
16 Controlled Trial Comparing the Performance of 22 Gauge Versus 25 Gauge EUS-FNA Needles (FNA-22G-25G) Completed NCT01016288
17 Assessment of Surgical sTaging vs Endoscopic Ultrasound in Lung Cancer: a Randomized Clinical Trial (ASTER Study) Completed NCT00432640 Not Applicable
18 Needlescopic-assisted Uniportal vs Uniportal VATS Recruiting NCT03439696 Not Applicable
19 Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging Not yet recruiting NCT03214341

Search NIH Clinical Center for Mediastinal Cancer

Cochrane evidence based reviews: mediastinal neoplasms

Genetic Tests for Mediastinal Cancer

Anatomical Context for Mediastinal Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinal Cancer:

19
The Mediastinum

MalaCards organs/tissues related to Mediastinal Cancer:

41
Lung, B Cells, Liver, Thymus

Publications for Mediastinal Cancer

Articles related to Mediastinal Cancer:

# Title Authors Year
1
Proximal thoracic aortic aneurysm mimicking a mediastinal neoplasm. ( 24035371 )
2013
2
Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia? ( 22824515 )
2012
3
Mental neuropathy (numb chin syndrome) leading to diagnosis of metastatic mediastinal cancer. ( 20592385 )
2010
4
Atrial flutter in a man with mediastinal cancer. ( 8595985 )
1996
5
[Diagnosis of mediastinal neoplasms using mediastinoscopy and CT-guided needle biopsy supported by gene analysis]. ( 8515159 )
1993
6
Acquired pulmonic stenosis. Report of a case caused by mediastinal neoplasm. ( 13965836 )
1962

Variations for Mediastinal Cancer

Expression for Mediastinal Cancer

Search GEO for disease gene expression data for Mediastinal Cancer.

Pathways for Mediastinal Cancer

Pathways related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.09 ANPEP GPHN NCAM1 SYP
2 11.24 ANPEP CD33 CD5 KIT
3 11.09 ANPEP CD33 CD5 KIT NCAM1
4 11.06 ANPEP KIT NCAM1
5 11.05 CD5 KIT

GO Terms for Mediastinal Cancer

Cellular components related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 ANPEP CD33 CD5 KIT NCAM1

Molecular functions related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.8 ANPEP CD33 CD5

Sources for Mediastinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....