MCID: MDS018
MIFTS: 37

Mediastinal Cancer

Categories: Cancer diseases

Aliases & Classifications for Mediastinal Cancer

MalaCards integrated aliases for Mediastinal Cancer:

Name: Mediastinal Cancer 12 15
Mediastinal Neoplasms 44 73
Malignant Tumor of Mediastinum 73
Neoplasm of Mediastinum 12
Tumour of Mediastinum 12
Mediastinum Cancer 12
Mediastinal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5559
ICD10 33 C38.3
ICD9CM 35 164.9
MeSH 44 D008479
NCIt 50 C3221 C3549
SNOMED-CT 68 93891008 94147001

Summaries for Mediastinal Cancer

Disease Ontology : 12 A thoracic cancer that is located in the mediastinum.

MalaCards based summary : Mediastinal Cancer, also known as mediastinal neoplasms, is related to thymus lipoma and myeloid sarcoma. An important gene associated with Mediastinal Cancer is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Hematopoietic cell lineage and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Midazolam and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and colon.

Related Diseases for Mediastinal Cancer

Diseases related to Mediastinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 thymus lipoma 29.7 CD5 SYP
2 myeloid sarcoma 29.5 KIT NCAM1
3 teratoma 29.5 AFP KIT SYP
4 small cell cancer of the lung 29.3 KIT NCAM1 SYP
5 gastrointestinal stromal tumor 29.3 KIT NCAM1 SYP
6 posterior mediastinum cancer 12.1
7 anemia, congenital dyserythropoietic, type ii 11.1
8 malignant mediastinal neurogenic neoplasm 11.1
9 liver lymphoma 10.3 AFP SMUG1
10 extragonadal nonseminomatous germ cell tumor 10.3 AFP SMUG1
11 sternum cancer 10.3 AFP SMUG1
12 corpus luteum cyst 10.3 AFP SMUG1
13 extragonadal germ cell cancer 10.2 AFP SMUG1
14 oculomotor nerve paralysis 10.2 AFP SMUG1
15 third cranial nerve disease 10.2 AFP SMUG1
16 malignant sertoli cell tumor 10.2 AFP SYP
17 prostate lymphoma 10.2 CD5 SMUG1
18 mature teratoma 10.2 AFP SMUG1
19 partial motor epilepsy 10.2 SMUG1 SYP
20 cellular ependymoma 10.2 SMUG1 SYP
21 malignant teratoma 10.2 AFP SYP
22 gastrointestinal neuroendocrine tumor 10.2 SMUG1 SYP
23 male reproductive organ benign neoplasm 10.2 AFP SYP
24 seminal vesicle tumor 10.2 AFP SYP
25 ectopic thymus 10.2 CD5 SYP
26 pancreatoblastoma 10.2 AFP SYP
27 pineoblastoma 10.2 AFP SYP
28 adult lymphoma 10.2 CD5 SMUG1
29 peliosis hepatis 10.2 AFP SMUG1
30 immune system organ benign neoplasm 10.2 CD5 SYP
31 ectopic cushing syndrome 10.2 SMUG1 SYP
32 tubular adenocarcinoma 10.2 AFP SYP
33 tracheal cancer 10.2 AFP SMUG1
34 ganglioneuroma 10.2 NCAM1 SYP
35 granulomatous myositis 10.2 NCAM1 SMUG1
36 esophageal neuroendocrine tumor 10.2 NCAM1 SYP
37 ovarian large-cell neuroendocrine carcinoma 10.2 NCAM1 SYP
38 lung combined type small cell carcinoma 10.1 NCAM1 SYP
39 bladder lymphoma 10.1 CD5 CD79A
40 dysgerminoma 10.1 AFP KIT
41 extrahepatic bile duct adenocarcinoma 10.1 NCAM1 SYP
42 cystadenofibroma 10.1 AFP NCAM1
43 orbital cancer 10.1 NCAM1 SYP
44 colon lymphoma 10.1 CD5 CD79A
45 hypoganglionosis 10.1 NCAM1 SYP
46 hepatic vascular disease 10.1 AFP CD33
47 panophthalmitis 10.1 CD79A SYP
48 mixed germ cell tumor 10.1 AFP KIT
49 pancreatic endocrine carcinoma 10.1 NCAM1 SYP
50 pancreatic serous cystadenoma 10.1 NCAM1 SYP

Graphical network of the top 20 diseases related to Mediastinal Cancer:



Diseases related to Mediastinal Cancer

Symptoms & Phenotypes for Mediastinal Cancer

Drugs & Therapeutics for Mediastinal Cancer

Drugs for Mediastinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
6 Anesthetics, General Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Epinephryl borate Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Central Nervous System Depressants Phase 4
12 Adrenergic alpha-2 Receptor Agonists Phase 4
13 Adrenergic Agents Phase 4
14 Anesthetics Phase 4
15 Adrenergic Agonists Phase 4
16 Narcotics Phase 4
17 Analgesics Phase 4
18 Anesthetics, Intravenous Phase 4
19 Analgesics, Opioid Phase 4
20 Hypnotics and Sedatives Phase 4
21 Neurotransmitter Agents Phase 4
22
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
23
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
24
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
25
Ifosfamide Approved Phase 3 3778-73-2 3690
26
Etoposide Approved Phase 3 33419-42-0 36462
27
Lenograstim Approved, Investigational Phase 3 135968-09-1
28 Liver Extracts Phase 3
29
Isophosphamide mustard Phase 3 0
30 Topoisomerase Inhibitors Phase 3
31 Alkylating Agents Phase 3
32 Antineoplastic Agents, Phytogenic Phase 3
33 Antibiotics, Antitubercular Phase 3,Phase 2
34 Antineoplastic Agents, Alkylating Phase 3
35 Etoposide phosphate Phase 3
36 Anti-Bacterial Agents Phase 3,Phase 2
37 Nucleic Acid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Evaluation of Dexmedetomidine for EBUS-TBNA Unknown status NCT01381627 Phase 4 Remifentanil;Dexmedetomidine
2 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
3 Mithramycin for Lung, Esophagus, and Other Chest Cancers Recruiting NCT01624090 Phase 2 Mithramycin
4 Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging Not yet recruiting NCT03214341

Search NIH Clinical Center for Mediastinal Cancer

Cochrane evidence based reviews: mediastinal neoplasms

Genetic Tests for Mediastinal Cancer

Anatomical Context for Mediastinal Cancer

MalaCards organs/tissues related to Mediastinal Cancer:

41
Lung, Liver, Colon, Prostate, Testis, B Cells, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinal Cancer:

19
The Mediastinum

Publications for Mediastinal Cancer

Articles related to Mediastinal Cancer:

(show all 15)
# Title Authors Year
1
Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia? ( 22824515 )
2012
2
Mental neuropathy (numb chin syndrome) leading to diagnosis of metastatic mediastinal cancer. ( 20592385 )
2010
3
Comparison of EUS-guided FNA and Trucut biopsy for diagnosing and staging abdominal and mediastinal neoplasms. ( 19217057 )
2009
4
Life-threatening presentation of mediastinal neoplasms: report on 7 consecutive pediatric patients. ( 15672342 )
2005
5
Management of critically ill children with mediastinal neoplasms: a 6-year survey from a single institution. ( 12652625 )
2003
6
Lymphoproliferative disorders presenting as mediastinal neoplasms. ( 11154724 )
2000
7
Minimally invasive approaches to mediastinal neoplasms. ( 11154725 )
2000
8
Atrial flutter in a man with mediastinal cancer. ( 8595985 )
1996
9
Touch imprints in the intraoperative diagnosis of anterior mediastinal neoplasms. ( 15456176 )
1996
10
[Diagnosis of mediastinal neoplasms using mediastinoscopy and CT-guided needle biopsy supported by gene analysis]. ( 8515159 )
1993
11
Primary mediastinal neoplasms (other than thymoma). ( 8396701 )
1993
12
Pitfalls in intraoperative frozen section histology of mediastinal neoplasms. ( 2268436 )
1990
13
Computed tomographic staging of anterior mediastinal neoplasms. ( 3420555 )
1988
14
Primary mediastinal neoplasms in infants and children. ( 4327175 )
1971
15
Mediastinal Cancer, Occurring Ten Years after Removal of the Breast, with Secondary Nodulation Well Distributed over the Head and Trunk. ( 30439170 )
1908

Variations for Mediastinal Cancer

Expression for Mediastinal Cancer

Search GEO for disease gene expression data for Mediastinal Cancer.

Pathways for Mediastinal Cancer

Pathways related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.12 CD33 CD5 KIT
2 11.09 CD33 CD5 CD79A KIT NCAM1
3 10.98 CD5 KIT
4 10.88 KIT NCAM1

GO Terms for Mediastinal Cancer

Cellular components related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 CD33 CD5 CD79A KIT NCAM1

Molecular functions related to Mediastinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.8 CD5 CD79A KIT

Sources for Mediastinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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