MCID: MDS006
MIFTS: 34

Mediastinal Gray Zone Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

MalaCards integrated aliases for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 12 15
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6867
NCIt 51 C37870
UMLS 74 C1334657

Summaries for Mediastinal Gray Zone Lymphoma

MalaCards based summary : Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to gray zone lymphoma and lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways/superpathways are NF-kappaB Signaling and Immune response IL-2 activation and signaling pathway. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include b cells, lung and colon, and related phenotypes are no effect and hematopoietic system

Related Diseases for Mediastinal Gray Zone Lymphoma

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 gray zone lymphoma 31.0 BCL11A CD274 CD79A PAX5 SLC22A2
2 lymphoma 30.6 BCL11A BCL6 PAX5 REL TNFRSF8
3 lymphoma, hodgkin, classic 30.6 BCL6 CD79A PAX5
4 primary mediastinal large b-cell lymphoma 30.4 BCL6 CD274 JAK2 XPO1
5 primary mediastinal b-cell lymphoma 30.3 BCL11A BCL6 REL XPO1
6 b-cell lymphomas 29.8 BCL6 PAX5 REL TNFRSF8
7 chromosome 2p16.1-p15 deletion syndrome 10.2 BCL11A REL XPO1
8 nodular lymphocyte predominant hodgkin lymphoma 10.2 BCL6 PAX5
9 primary central nervous system lymphoma 10.2 BCL6 CD274 PAX5
10 composite lymphoma 10.2 BCL6 PAX5
11 breast lymphoma 10.2 BCL6 CD79A
12 bladder lymphoma 10.2 CD79A PAX5
13 malignant leydig cell tumor 10.1 PAX5 TNFRSF8
14 intraocular lymphoma 10.1 BCL6 PAX5
15 t-cell/histiocyte rich large b cell lymphoma 10.0 BCL6 SLC22A2 TNFRSF8
16 sternum cancer 10.0 FUT4 TNFRSF8
17 pediatric lymphoma 10.0 CD79A DAPK1 TNFRSF8
18 reticulosarcoma 10.0 BCL6 PAX5 TNFRSF8
19 colon lymphoma 10.0 BCL6 CD79A TNFRSF8
20 lymphatic system cancer 9.9 BCL6 CD79A TNFRSF8
21 lung lymphoma 9.9 BCL6 CD79A PAX5 TNFRSF8
22 leukocyte disease 9.9 BCL6 CD79A PAX5 TNFRSF8
23 epidural neoplasm 9.9 BCL6 FUT4 TNFRSF8
24 hodgkin's lymphoma, lymphocytic depletion 9.8 CD79A FUT4 PAX5 TNFRSF8
25 myasthenic syndrome, congenital, 14 9.8 CD274 JAK2 PDCD1LG2
26 diffuse large b-cell lymphoma 9.8 BCL6 CD79A REL TNFRSF8
27 epstein-barr virus-associated gastric carcinoma 9.8 CD274 JAK2 PDCD1LG2
28 testicular infarct 9.7 FUT4 TNFRSF8
29 lymphoma, non-hodgkin, familial 9.6 BCL6 CD79A JAK2 PAX5 TNFRSF8
30 hematologic cancer 9.4 BCL6 IL3RA JAK2 PAX5 TNFRSF8
31 mediastinal malignant lymphoma 6.9 BCL11A BCL6 CD274 CD79A DAPK1 EPHA7

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to Mediastinal Gray Zone Lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 BCL11A BCL6 CD274 CD79A CD83 DAPK1

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 BCL11A BCL6 CD274 CD79A CD83 FUT4
2 cellular MP:0005384 10.06 BCL11A BCL6 CD274 CD79A DAPK1 FUT4
3 homeostasis/metabolism MP:0005376 9.93 BCL11A BCL6 CD274 CD79A DAPK1 HMOX1
4 immune system MP:0005387 9.83 BCL11A BCL6 CD274 CD79A CD83 FUT4
5 normal MP:0002873 9.23 BCL6 CD79A CD83 HOXA5 JAK2 PAX5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 1, Phase 2 946414-94-4
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 Antibodies Phase 1, Phase 2
5 Antibodies, Monoclonal Phase 1, Phase 2
6 Immunoglobulins Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas Active, not recruiting NCT02581631 Phase 1, Phase 2 Brentuximab Vedotin
2 Mediastinal Grey Zone Lymphoma From the LYSA Completed NCT03037177

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

42
B Cells, Lung, Colon, Breast, T Cells

Publications for Mediastinal Gray Zone Lymphoma

Articles related to Mediastinal Gray Zone Lymphoma:

(show all 15)
# Title Authors Year
1
Dendritic Cell Markers and PD-L1 are Expressed in Mediastinal Gray Zone Lymphoma. ( 29189264 )
2018
2
Long-term complete remission following tandem autologous stem cell transplantation and consolidative radiotherapy for refractory mediastinal gray-zone lymphoma. ( 29786758 )
2018
3
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. ( 27758822 )
2017
4
PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. ( 28679093 )
2017
5
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. ( 27623181 )
2016
6
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? ( 26957476 )
2016
7
Mediastinal Gray Zone Lymphoma. ( 27164737 )
2015
8
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? ( 25499450 )
2015
9
A prospective study of mediastinal gray-zone lymphoma. ( 25024303 )
2014
10
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. ( 21366467 )
2011
11
Mediastinal gray zone lymphoma. ( 21454881 )
2011
12
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. ( 21454882 )
2011
13
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? ( 21590365 )
2011
14
Two cases of mediastinal gray zone lymphoma. ( 21123972 )
2010
15
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. ( 16224207 )
2005

Variations for Mediastinal Gray Zone Lymphoma

Expression for Mediastinal Gray Zone Lymphoma

Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for Mediastinal Gray Zone Lymphoma

GO Terms for Mediastinal Gray Zone Lymphoma

Cellular components related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endomembrane system GO:0012505 9.13 CD274 JAK2 PDCD1LG2
2 external side of plasma membrane GO:0009897 9.02 CD274 CD79A CD83 IL3RA PDCD1LG2

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.55 BCL6 HMOX1 IL3RA JAK2 MAOA
2 negative regulation of interleukin-10 production GO:0032693 9.32 CD274 PDCD1LG2
3 negative regulation of activated T cell proliferation GO:0046007 9.26 CD274 PDCD1LG2
4 positive regulation of apoptotic process GO:0043065 9.1 BCL6 EPHA7 HMOX1 HOXA5 JAK2 TNFRSF8
5 negative regulation of mast cell cytokine production GO:0032764 8.96 BCL6 HMOX1

Sources for Mediastinal Gray Zone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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