MCID: MDS006
MIFTS: 21

Mediastinal Gray Zone Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

MalaCards integrated aliases for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 12 15
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6867
NCIt 50 C37870
UMLS 73 C1334657

Summaries for Mediastinal Gray Zone Lymphoma

MalaCards based summary : Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to gray zone lymphoma and lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5). The drugs Nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include b cells.

Related Diseases for Mediastinal Gray Zone Lymphoma

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gray zone lymphoma 30.6 CD274 PAX5 SLC22A2
2 lymphoma 10.6
3 b-cell lymphomas 10.5
4 lymphoma, hodgkin, classic 10.3
5 primary mediastinal large b-cell lymphoma 10.3
6 primary mediastinal b-cell lymphoma 10.2
7 primary central nervous system lymphoma 9.9 CD274 PAX5
8 merkel cell carcinoma 9.8 CD274 PAX5
9 mediastinal malignant lymphoma 9.4 CD274 EPHA7 HOXA5 PAX5

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to Mediastinal Gray Zone Lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 1, Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 1, Phase 2
3 Antibodies Phase 1, Phase 2
4 Immunoglobulins Phase 1, Phase 2
5 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas Recruiting NCT02581631 Phase 1, Phase 2 Brentuximab Vedotin
2 Mediastinal Grey Zone Lymphoma From the LYSA Completed NCT03037177

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

41
B Cells

Publications for Mediastinal Gray Zone Lymphoma

Articles related to Mediastinal Gray Zone Lymphoma:

(show all 15)
# Title Authors Year
1
Long-term complete remission following tandem autologous stem cell transplantation and consolidative radiotherapy for refractory mediastinal gray-zone lymphoma. ( 29786758 )
2018
2
PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. ( 28679093 )
2017
3
Dendritic Cell Markers and PD-L1 are Expressed in Mediastinal Gray Zone Lymphoma. ( 29189264 )
2017
4
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. ( 27758822 )
2017
5
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. ( 27623181 )
2016
6
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? ( 26957476 )
2016
7
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? ( 25499450 )
2015
8
Mediastinal Gray Zone Lymphoma. ( 27164737 )
2015
9
A prospective study of mediastinal gray-zone lymphoma. ( 25024303 )
2014
10
Mediastinal gray zone lymphoma. ( 21454881 )
2011
11
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. ( 21454882 )
2011
12
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? ( 21590365 )
2011
13
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. ( 21366467 )
2011
14
Two cases of mediastinal gray zone lymphoma. ( 21123972 )
2010
15
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. ( 16224207 )
2005

Variations for Mediastinal Gray Zone Lymphoma

Expression for Mediastinal Gray Zone Lymphoma

Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for Mediastinal Gray Zone Lymphoma

GO Terms for Mediastinal Gray Zone Lymphoma

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 8.8 EPHA7 HOXA5 PAX5

Sources for Mediastinal Gray Zone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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