MCID: MDS006
MIFTS: 24

Mediastinal Gray Zone Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Gray Zone Lymphoma

MalaCards integrated aliases for Mediastinal Gray Zone Lymphoma:

Name: Mediastinal Gray Zone Lymphoma 12 15
Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6867
NCIt 49 C37870
UMLS 71 C1334657

Summaries for Mediastinal Gray Zone Lymphoma

MalaCards based summary : Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to primary mediastinal b-cell lymphoma and b-cell lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is PAX5 (Paired Box 5), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs rituximab and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Mediastinal Gray Zone Lymphoma

Diseases related to Mediastinal Gray Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 primary mediastinal b-cell lymphoma 30.6 KDM4C BCL11A
2 b-cell lymphoma 30.5 TNFRSF8 PAX5 BCL11A
3 diffuse large b-cell lymphoma 29.7 TNFRSF8 PAX5 CD79A
4 lymphoma, hodgkin, classic 29.7 TNFRSF8 SLC22A2 POU2AF1 PAX5 KDM4C
5 composite lymphoma 28.9 TNFRSF8 PAX5 FUT4 CD79A
6 lymphoma, non-hodgkin, familial 28.8 TNFRSF8 PAX5 KDM4C CD79A
7 hodgkin's lymphoma, nodular sclerosis 28.5 TNFRSF8 PAX5 KDM4C FUT4 CD79A
8 gray zone lymphoma 28.4 TNFRSF8 SLC22A2 POU2AF1 PAX5 GPR15 FUT4
9 lymphoma 10.7
10 primary mediastinal large b-cell lymphoma 10.5
11 nodular lymphocyte predominant hodgkin lymphoma 10.1 TNFRSF8 PAX5
12 submandibular adenitis 10.1 TNFRSF8 PAX5
13 breast lipoma 10.1 TNFRSF8 PAX5
14 scott syndrome 10.1
15 dermatitis 10.1
16 b-cell non-hodgkin lymphoma 10.1
17 spherocytosis, type 4 10.1 POU2AF1 PAX5
18 t-cell/histiocyte rich large b cell lymphoma 10.1 TNFRSF8 SLC22A2
19 tracheal lymphoma 10.0 TNFRSF8 PAX5
20 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.0 TNFRSF8 FUT4
21 pleural lipoma 10.0 TNFRSF8 FUT4
22 uterus leiomyosarcoma 10.0 TNFRSF8 FUT4
23 reticulosarcoma 9.9 TNFRSF8 PAX5
24 germ cell and embryonal cancer 9.9 KDM4C FUT4
25 monoclonal paraproteinemia 9.9 PAX5 CD79A
26 adult acute lymphocytic leukemia 9.9 TNFRSF8 PAX5
27 spleen cancer 9.9 PAX5 CD79A
28 cll/sll 9.9 PAX5 CD79A
29 multicentric castleman disease 9.8 PAX5 CD79A
30 myeloid sarcoma 9.8 PAX5 CD79A
31 plasma cell neoplasm 9.7 PAX5 CD79A
32 testicular disease 9.7 TNFRSF8 KDM4C
33 lymphoblastic lymphoma 9.7 TNFRSF8 PAX5
34 infected hydrocele 9.7 TNFRSF8 CD79A
35 gastrointestinal lymphoma 9.7 TNFRSF8 CD79A
36 cerebral lymphoma 9.7 TNFRSF8 CD79A
37 pediatric lymphoma 9.7 TNFRSF8 CD79A
38 membranoproliferative glomerulonephritis 9.7 FUT4 CD79A
39 testicular lymphoma 9.7 TNFRSF8 CD79A
40 pleural empyema 9.7 TNFRSF8 CD79A
41 sickle cell anemia 9.5 FUT4 BCL11A
42 lung lymphoma 9.5 TNFRSF8 PAX5 CD79A
43 bone lymphoma 9.5 TNFRSF8 PAX5 CD79A
44 paranasal sinus lymphoma 9.5 TNFRSF8 PAX5 CD79A
45 breast lymphoma 9.5 TNFRSF8 PAX5 CD79A
46 hodgkin's lymphoma, mixed cellularity 9.4 TNFRSF8 FUT4 CD79A
47 lymphatic system cancer 9.4 TNFRSF8 KDM4C CD79A
48 lymphatic system disease 9.4 TNFRSF8 KDM4C CD79A
49 central nervous system hematologic cancer 9.2 TNFRSF8 PAX5 KDM4C CD79A
50 marginal zone b-cell lymphoma 9.2 TNFRSF8 PAX5 KDM4C CD79A

Graphical network of the top 20 diseases related to Mediastinal Gray Zone Lymphoma:



Diseases related to Mediastinal Gray Zone Lymphoma

Symptoms & Phenotypes for Mediastinal Gray Zone Lymphoma

GenomeRNAi Phenotypes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.47 POU2AF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.47 TNFRSF8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU2AF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 POU2AF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-150 9.47 KDM4C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.47 TNFRSF8
7 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.47 KDM4C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.47 POU2AF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-209 9.47 KDM4C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.47 POU2AF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.47 TNFRSF8
12 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.47 TNFRSF8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.47 TNFRSF8
14 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.47 KDM4C

MGI Mouse Phenotypes related to Mediastinal Gray Zone Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 BCL11A CD79A FUT4 GPR15 KDM4C PAX5
2 immune system MP:0005387 9.23 BCL11A CD79A FUT4 GPR15 KDM4C PAX5

Drugs & Therapeutics for Mediastinal Gray Zone Lymphoma

Drugs for Mediastinal Gray Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2 174722-31-7 10201696
2
nivolumab Approved Phase 1, Phase 2 946414-94-4
3 Immunologic Factors Phase 2
4 Antirheumatic Agents Phase 2
5 Antineoplastic Agents, Immunological Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Adults and Children With Previously Untreated Patients With Aggressive Non-Hodgkin's Lymphoma Recruiting NCT00001337 Phase 2 EPOCH
2 A Phase I/ II Study to Evaluate the Safety and Preliminary Efficacy of Nivolumab in Combination With Brentuximab Vedotin in Subjects With Relapsed Refractory Non Hodgkin Lymphomas With CD30 Expression (CheckMate 436: CHECKpoint Pathway and Nivolumab Clinical Trial Evaluation 436) Active, not recruiting NCT02581631 Phase 1, Phase 2 Brentuximab Vedotin

Search NIH Clinical Center for Mediastinal Gray Zone Lymphoma

Genetic Tests for Mediastinal Gray Zone Lymphoma

Anatomical Context for Mediastinal Gray Zone Lymphoma

MalaCards organs/tissues related to Mediastinal Gray Zone Lymphoma:

40
B Cells

Publications for Mediastinal Gray Zone Lymphoma

Articles related to Mediastinal Gray Zone Lymphoma:

(show all 32)
# Title Authors PMID Year
1
Pruritic cutaneous lesions mimicking dermatitis artefacta in the course of mediastinal gray-zone lymphoma. 61
32489369 2020
2
Long-term Remission by Brentuximab Vedotin for Non-mediastinal Gray Zone Lymphoma Refractory to Autologous Stem Cell Transplantation. 61
31551171 2019
3
Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 1. 61
31567132 2019
4
Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 2. 61
31567129 2019
5
EBV-Positive Primary Large B-Cell Lymphoma: The Role of Immunohistochemistry and XPO1 in the Diagnosis of Mediastinal Lymphomas. 61
31789821 2019
6
The utility of CD83, fascin and CD23 in the differential diagnosis of primary mediastinal large B-cell lymphoma versus classic Hodgkin lymphoma. 61
31075666 2019
7
Gray-zone lymphoma. Examples of rare clinical manifestation. 61
31094484 2019
8
Dendritic Cell Markers and PD-L1 are Expressed in Mediastinal Gray Zone Lymphoma. 61
29189264 2018
9
Long-term complete remission following tandem autologous stem cell transplantation and consolidative radiotherapy for refractory mediastinal gray-zone lymphoma. 61
29786758 2018
10
Primary mediastinal B-cell lymphoma: biology and evolving therapeutic strategies. 61
29222270 2017
11
Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma. 61
28722111 2017
12
PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. 61
28679093 2017
13
Management of Primary Mediastinal B-Cell Lymphoma and Gray Zone Lymphoma. 61
28620906 2017
14
Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association. 61
27758822 2017
15
The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome. 61
27419920 2016
16
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma. 61
27312795 2016
17
Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? 61
26957476 2016
18
[Mediastinal gray zone lymphoma: a case report and literature review]. 61
27431084 2016
19
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. 61
27623181 2016
20
Mediastinal Gray Zone Lymphoma. 61
27164737 2015
21
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? 61
25499450 2015
22
A prospective study of mediastinal gray-zone lymphoma. 61
25024303 2014
23
Clinicopathological analysis of mediastinal large B-cell lymphoma and classical Hodgkin lymphoma of the mediastinum. 61
23020783 2013
24
Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma? 61
22833351 2012
25
Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do? 61
21590365 2011
26
Mediastinal gray zone lymphoma. 61
21454881 2011
27
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. 61
21454882 2011
28
Primary mediastinal (thymic) large B-cell lymphoma: a short review with brief discussion of mediastinal gray zone lymphoma. 61
21366467 2011
29
Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. 61
20971819 2011
30
Two cases of mediastinal gray zone lymphoma. 61
21123972 2010
31
[Mediastinal gray zone lymphoma: report of a case]. 61
19031730 2008
32
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. 61
16224207 2005

Variations for Mediastinal Gray Zone Lymphoma

Expression for Mediastinal Gray Zone Lymphoma

Search GEO for disease gene expression data for Mediastinal Gray Zone Lymphoma.

Pathways for Mediastinal Gray Zone Lymphoma

Pathways related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.31 TNFRSF8 PAX5 CD79A

GO Terms for Mediastinal Gray Zone Lymphoma

Biological processes related to Mediastinal Gray Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 humoral immune response GO:0006959 8.62 POU2AF1 PAX5

Sources for Mediastinal Gray Zone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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