MCID: MDS003
MIFTS: 24

Mediastinal Lipomatosis

Categories: Skin diseases
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Aliases & Classifications for Mediastinal Lipomatosis

MalaCards integrated aliases for Mediastinal Lipomatosis:

Name: Mediastinal Lipomatosis 11 14 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3926
NCIt 49 C27488
UMLS 71 C1334662

Summaries for Mediastinal Lipomatosis

MalaCards based summary: Mediastinal Lipomatosis is related to pericardial effusion and pituitary-dependent cushing's disease. An important gene associated with Mediastinal Lipomatosis is LY86 (Lymphocyte Antigen 86), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Development_Leptin signaling via JAK/STAT and MAPK cascades. Affiliated tissues include skin, trachea and kidney, and related phenotype is adipose tissue.

Related Diseases for Mediastinal Lipomatosis

Diseases related to Mediastinal Lipomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 pericardial effusion 29.6 MB CRP
2 pituitary-dependent cushing's disease 29.6 POMC NR3C1 CRH
3 alcohol use disorder 29.4 POMC CRP CRH
4 lipid metabolism disorder 29.4 POMC MB CRP
5 conn's syndrome 29.4 SYP POMC NR3C1 CRP CRH
6 lipomatosis 10.7
7 thymus lipoma 10.2 MB HMGA2
8 immune system organ benign neoplasm 10.2 MB HMGA2
9 orbit embryonal rhabdomyosarcoma 10.2 MB HMGA2
10 orbit rhabdomyosarcoma 10.2 MB HMGA2
11 appendix carcinoid tumor 10.2 SYP POMC
12 premature ovarian failure 7 10.2 POMC CRH
13 pituitary infarct 10.1 POMC CRH
14 somatization disorder 10.1 POMC CRH
15 lung oat cell carcinoma 10.1 SYP POMC
16 sheehan syndrome 10.1 POMC CRH
17 hypothalamic disease 10.1 POMC CRH
18 melancholia 10.1 POMC CRH
19 retrograde amnesia 10.1 POMC CRH
20 medullomyoblastoma 10.1 SYP MB
21 malignant olfactory nerve neoplasm 10.1 SYP POMC
22 sexual sadism 10.1 POMC CRH
23 cranial nerve malignant neoplasm 10.1 SYP POMC
24 pancreatic endocrine carcinoma 10.1 SYP POMC
25 acth deficiency, isolated 10.1 POMC CRH
26 alzheimer disease 16 10.1 POMC NR3C1
27 autonomic nervous system benign neoplasm 10.1 SYP POMC
28 peripheral nervous system benign neoplasm 10.1 SYP POMC
29 central epithelioid sarcoma 10.1 SYP MB
30 vulvar proximal-type epithelioid sarcoma 10.1 SYP MB
31 hyperpituitarism 10.1 POMC CRH
32 adrenal cortical hypofunction 10.1 POMC CRH
33 ovarian serous adenofibroma 10.1 POMC NR3C1
34 acth-independent macronodular adrenal hyperplasia 10.1 POMC CRH
35 phobic disorder 10.1 POMC CRH
36 corticosteroid-binding globulin deficiency 10.1 POMC NR3C1
37 opiate dependence 10.1 POMC CRH
38 withdrawal disorder 10.1 POMC CRH
39 persistent fetal circulation syndrome 10.1 POMC CRH
40 functioning pituitary adenoma 10.1 POMC CRH
41 social phobia 10.0 POMC CRH
42 binswanger's disease 10.0 SYP CRH
43 skin atrophy 10.0 POMC NR3C1
44 thyroid gland medullary carcinoma 10.0 SYP POMC
45 pancreatic cystadenoma 10.0 SYP POMC
46 hyperaldosteronism, familial, type i 10.0 POMC NR3C1
47 mediastinum teratoma 10.0 POMC CRP
48 sphenoid sinusitis 10.0 POMC CRP
49 primary pigmented nodular adrenocortical disease 10.0 POMC CRH
50 cavernous sinus thrombosis 10.0 POMC CRP

Graphical network of the top 20 diseases related to Mediastinal Lipomatosis:



Diseases related to Mediastinal Lipomatosis

Symptoms & Phenotypes for Mediastinal Lipomatosis

MGI Mouse Phenotypes related to Mediastinal Lipomatosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.02 CRH HMGA2 NR3C1 POMC XDH

Drugs & Therapeutics for Mediastinal Lipomatosis

Search Clinical Trials, NIH Clinical Center for Mediastinal Lipomatosis

Genetic Tests for Mediastinal Lipomatosis

Anatomical Context for Mediastinal Lipomatosis

Organs/tissues related to Mediastinal Lipomatosis:

MalaCards : Skin, Trachea, Kidney

Publications for Mediastinal Lipomatosis

Articles related to Mediastinal Lipomatosis:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Unusual cause of mediastinal widening and atrial fibrillation: mediastinal lipomatosis with infiltration into the interatrial septum. 62
34753735 2021
2
Mediastinal and pleural lipomatosis as a manifestation of myotonic dystrophy type 1. 62
34472530 2021
3
Ectopic Cushing syndrome caused by a pancreatic neuroendocrine tumor: A case report. 62
32547669 2020
4
A Rare Case of Sarcoidosis-Induced Polyserositis and Steroid-Induced Mediastinal Lipomatosis Masquerading as an Epicardial Tumor. 62
32577599 2020
5
Pleural and Mediastinal Lipomatosis with Subpleural Fat as a Mimicker of Pleural Effusion- A Rare Case Report. 62
28893005 2017
6
Unexpected transesophageal echocardiography tee finding: mediastinal lipomatosis fakes an aortic intramural haematoma. 62
28275569 2017
7
Mediastinal Lipomatosis with Dyslipidemia: Cause of Dyspnea. 62
27805346 2016
8
Mediastinal Lipomatosis Presenting as Persistent Pneumonia. 62
26004000 2015
9
Critical tracheal stenosis caused by mediastinal lipomatosis: Long-term efficacy of airway stenting. 62
25686656 2015
10
[Mediastinal lipomatosis]. 62
23924533 2013
11
CT to the rescue in benign, symmetrical mediastinal lipomatosis. 62
22618622 2012
12
Unusual cause of right ventricular outflow tract compression: mediastinal lipomatosis. 62
21052024 2011
13
[Corticosteroid-induced mediastinal lipomatosis in a patient with overlap syndrome (autoimmune hepatitis-primary biliary cirrhosis)]. 62
21636175 2011
14
Images in clinical medicine. Asymptomatic mediastinal lipomatosis. 62
20860508 2010
15
Postoperative mediastinal lipomatosis. 62
19041845 2008
16
Mediastinal lipomatosis as a cause of low voltage complexes on electrocardiogram and widened mediastinum: A case report. 62
18803846 2008
17
Primary mediastinal large B-cell lymphoma mimicking liposarcoma. 62
18066682 2008
18
Lipomatous hypertrophy of the interatrial septum associated with fatty replacement of the ventricular myocardium: a case report. 62
17659553 2007
19
Atypical mediastinal lipomatosis. 62
17509429 2007
20
[Precocious mediastinal lipomatosis: a rare complication of systemic corticosteroid therapy]. 62
16800178 2006
21
Cushing's syndrome with mediastinal lipomatosis. 62
15322612 2004
22
Anesthetic considerations in steroid-induced mediastinal lipomatosis. 62
14980954 2004
23
[A corticosteroid-induced mediastinal lipomatosis in an asthmatic patient]. 62
12876528 2003
24
Mediastinal widening in a patient of ulcerative colitis. 62
12715937 2003
25
[Lipodystrophic syndrome associated with infection with the human immunodeficiency virus and mediastinal lipomatosis]. 62
12605791 2003
26
Mediastinal lipomatosis and exogenous steroids. 62
12187610 2002
27
Extensive mediastinal lipomatosis in a patient with severe aortic valve stenosis. 62
11888787 2002
28
[Diagnostic image (71). A woman with obesity, diabetes mellitus and use of corticosteroids. Mediastinal lipomatosis]. 62
11820059 2002
29
A new CT sign of mediastinal lipomatosis? 62
11868107 2002
30
Isolated symmetrical mediastinal lipomatosis. 62
11848311 2001
31
Spontaneous hemomediastinum complicating steroid-induced mediastinal lipomatosis. 62
11451858 2001
32
Steroid-induced mediastinal lipomatosis with radiographic features of pericardial effusion. 62
10830702 2000
33
Primary liposarcoma of the mediastinum with coexistent mediastinal lipomatosis. 62
10658747 2000
34
Lipomatosis due to chronic steroid therapy. 62
10558449 1999
35
Mediastinal lipomatosis. 62
9853734 1998
36
[Intrathoracic mass as presenting form of mediastinal lipomatosis]. 62
9882865 1998
37
CT appearance of lipomatous hypertrophy of the interatrial septum. 62
9124119 1997
38
[Mediastinal lipomatosis and obesity]. 62
8948829 1996
39
[Diffuse mediastinal lipomatosis and exogenous obesity]. 62
7984809 1994
40
Extrapleural fat collections: pseudotumors and other confusing manifestations. 62
8517319 1993
41
[Diffuse mediastinal lipomatosis and exogenous obesity]. 62
8497720 1993
42
Sebaceous naevus of Jadassohn and primary mediastinal lipomatosis. 62
8490711 1993
43
Late onset primary systemic carnitine deficiency exacerbated by carnitine-free parenteral nutrition. 62
16840023 1992
44
'Sabre sheath' trachea with mediastinal lipomatosis mimicking a mediastinal tumour. 62
1773563 1991
45
Computed tomography of mediastinal collaterals in SVC syndrome. 62
3170853 1988
46
[Iatrogenic Cushing's syndrome with mediastinal lipomatosis simulating cardiomegaly and pleural effusion: report of a case]. 62
2976421 1988
47
Mediastinal lipomatosis: a complication of high dose steroid therapy in children. 62
3222066 1988
48
[Steroid mediastinal lipomatosis]. 62
6708627 1984
49
[Mediastinal lipomatosis simulating cardiomegaly]. 62
6230220 1984
50
The apical cap. 62
6789637 1981

Variations for Mediastinal Lipomatosis

Expression for Mediastinal Lipomatosis

Search GEO for disease gene expression data for Mediastinal Lipomatosis.

Pathways for Mediastinal Lipomatosis

Pathways related to Mediastinal Lipomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 NR3C1 HMGA2 FBL
2
Show member pathways
10.63 POMC CRP
3
Show member pathways
10.42 POMC CRH
4 9.47 POMC CRH

GO Terms for Mediastinal Lipomatosis

Biological processes related to Mediastinal Lipomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenal gland development GO:0030325 8.92 NR3C1 CRH

Sources for Mediastinal Lipomatosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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